| 1982-04-10 | vs TEX | 1 | L 3-8 | 0-1 | 5 | 62,443 | Rick Waits | Charlie Hough | Charlie Hough | Rick Waits | | 3 | 8 | -5 |
| 1982-04-11 | vs TEX | 2 | W 13-1 | 1-1 | 4 | 3,821 | Len Barker | Doc Medich | Len Barker | Doc Medich | | 16 | 9 | 7 |
| 1982-04-13 | vs MIL | 3 | L 8-9 | 1-2 | 7 | 6,258 | Lary Sorensen | Randy Lerch | Rollie Fingers | Dennis Lewallyn | | 24 | 18 | 6 |
| 1982-04-14 | vs MIL | 4 | W 6-2 | 2-2 | 2 | 7,017 | John Denny | Pete Vuckovich | John Denny | Pete Vuckovich | | 30 | 20 | 10 |
| 1982-04-15 | vs MIL | 5 | W 8-1 | 3-2 | 1 | 9,072 | Bert Blyleven | Mike Caldwell | Bert Blyleven | Mike Caldwell | | 38 | 21 | 17 |
| 1982-04-16 | vs KCA | 6 | L 1-3 | 3-3 | 1 | 6,360 | Len Barker | Vida Blue | Vida Blue | Len Barker | Dan Quisenberry | 39 | 24 | 15 |
| 1982-04-17 | vs KCA | 7 | L 10-12 | 3-4 | 3 | 7,089 | Lary Sorensen | Larry Gura | Dave Frost | Rick Waits | Dan Quisenberry | 49 | 36 | 13 |
| 1982-04-18 | vs KCA | 8 | W 8-2 | 4-4 | 1 | 11,373 | John Denny | Buddy Black | John Denny | Buddy Black | | 57 | 38 | 19 |
| 1982-04-20 | @ TEX | 9 | W 9-4 | 5-4 | 2 | 10,352 | Bert Blyleven | Charlie Hough | Bert Blyleven | Charlie Hough | | 66 | 42 | 24 |
| 1982-04-21 | @ TEX | 10 | L 2-4 | 5-5 | 3 | 8,457 | Rick Waits | Doc Medich | Doc Medich | Rick Waits | Steve Comer | 68 | 46 | 22 |
| 1982-04-22 | @ TEX | 11 | W 4-3 | 6-5 | 2 | 8,954 | Len Barker | Frank Tanana | Len Barker | Frank Tanana | Dan Spillner | 72 | 49 | 23 |
| 1982-04-23 | @ KCA | 12 | L 6-11 | 6-6 | 3 | 24,332 | Lary Sorensen | Dennis Leonard | Grant Jackson | Lary Sorensen | | 78 | 60 | 18 |
| 1982-04-24 | @ KCA | 13 | L 1-5 | 6-7 | 4 | 25,065 | John Denny | Paul Splittorff | Paul Splittorff | John Denny | Dan Quisenberry | 79 | 65 | 14 |
| 1982-04-25 | @ KCA | 14 | L 3-6 | 6-8 | 4 | 20,867 | Bert Blyleven | Larry Gura | Larry Gura | Bert Blyleven | | 82 | 71 | 11 |
| 1982-04-27 | vs SEA | 15 | L 4-7 | 6-9 | 4 | 3,275 | Rick Waits | Floyd Bannister | Bill Caudill | Dan Spillner | Ed Vande Berg | 86 | 78 | 8 |
| 1982-04-28 | vs SEA | 16 | W 6-1 | 7-9 | 4 | 3,889 | Len Barker | Mike Moore | Len Barker | Mike Moore | | 92 | 79 | 13 |
| 1982-04-29 | vs SEA | 17 | W 5-1 | 8-9 | 4 | 3,984 | Lary Sorensen | Gene Nelson | Lary Sorensen | Gene Nelson | | 97 | 80 | 17 |
| 1982-04-30 | vs OAK | 18 | L 0-8 | 8-10 | 4 | 11,113 | John Denny | Rick Langford | Rick Langford | John Denny | | 97 | 88 | 9 |
| 1982-05-01 | vs OAK | 19 | L 2-8 | 8-11 | 4 | 20,634 | Bert Blyleven | Jeff Jones | Jeff Jones | Bert Blyleven | Tom Underwood | 99 | 96 | 3 |
| 1982-05-02 | vs OAK | 20 | L 2-5 | 8-12 | 6 | 22,385 | Rick Waits | Mike Norris | Mike Norris | Rick Waits | | 101 | 101 | 0 |
| 1982-05-03 | vs CAL | 21 | L 4-5 | 8-13 | 7 | 6,844 | Len Barker | Mike Witt | Don Aase | Dan Spillner | | 105 | 106 | -1 |
| 1982-05-04 | vs CAL | 22 | W 6-5 | 9-13 | 4 | 5,435 | Lary Sorensen | Geoff Zahn | Lary Sorensen | Geoff Zahn | Dan Spillner | 111 | 111 | 0 |
| 1982-05-06 | @ OAK | 23 | L 2-4 | 9-14 | 5 | 15,373 | John Denny | Steve McCatty | Steve McCatty | John Denny | Dave Beard | 113 | 115 | -2 |
| 1982-05-07 | @ OAK | 24 | W 15-6 | 10-14 | 5 | 22,314 | Rick Waits | Rick Langford | Rick Sutcliffe | Rick Langford | Ed Whitson | 128 | 121 | 7 |
| 1982-05-08 | @ OAK | 25 | W 8-5 | 11-14 | 4 | 37,408 | Len Barker | Mike Norris | Len Barker | Mike Norris | Dan Spillner | 136 | 126 | 10 |
| 1982-05-09 | @ OAK | 26 | W 14-2 | 12-14 | 4 | 30,386 | Lary Sorensen | Matt Keough | Lary Sorensen | Matt Keough | | 150 | 128 | 22 |
| 1982-05-10 | @ SEA | 27 | L 4-6 | 12-15 | 4 | 4,625 | John Bohnet | Mike Moore | Ed Vande Berg | Rick Sutcliffe | Bill Caudill | 154 | 134 | 20 |
| 1982-05-11 | @ SEA | 28 | W 5-4 | 13-15 | 4 | 14,454 | John Denny | Gaylord Perry | Ed Whitson | Bill Caudill | | 159 | 138 | 21 |
| 1982-05-12 | @ SEA | 29 | W 8-5 | 14-15 | 4 | 4,691 | Rick Waits | Floyd Bannister | Rick Sutcliffe | Floyd Bannister | | 167 | 143 | 24 |
| 1982-05-13 | @ CAL | 30 | L 2-3 | 14-16 | 4 | 21,459 | Len Barker | Steve Renko | Andy Hassler | Dan Spillner | | 169 | 146 | 23 |
| 1982-05-14 | @ CAL | 31 | L 2-5 | 14-17 | 5 | 26,862 | Lary Sorensen | Bruce Kison | Bruce Kison | Lary Sorensen | Doug Corbett | 171 | 151 | 20 |
| 1982-05-15 | @ CAL | 32 | L 6-9 | 14-18 | 5 | 41,557 | John Bohnet | Geoff Zahn | Mike Witt | Tom Brennan | Doug Corbett | 177 | 160 | 17 |
| 1982-05-16 | @ CAL | 33 | L 0-3 | 14-19 | 6 | 27,054 | John Denny | Ken Forsch | Ken Forsch | John Denny | | 177 | 163 | 14 |
| 1982-05-18 | vs TOR | 34 | W 6-5 | 15-19 | 5 | 5,865 | Rick Sutcliffe | Dave Stieb | Dan Spillner | Dale Murray | | 183 | 168 | 15 |
| 1982-05-19 | vs TOR | 35 | L 5-8 | 15-20 | 6 | 5,724 | Len Barker | Luis Leal | Jerry Garvin | Len Barker | Joey McLaughlin | 188 | 176 | 12 |
| 1982-05-20 | vs TOR | 36 | L 0-2 | 15-21 | 7 | 6,226 | Lary Sorensen | Jim Clancy | Jim Clancy | Lary Sorensen | | 188 | 178 | 10 |
| 1982-05-21 | @ CHA | 37 | L 2-3 | 15-22 | 7 | 22,567 | John Bohnet | Britt Burns | Britt Burns | Dan Spillner | | 190 | 181 | 9 |
| 1982-05-22 | @ CHA | 38 | L 3-7 | 15-23 | 7 | 20,558 | John Denny | Steve Trout | Steve Trout | John Denny | Jerry Koosman | 193 | 188 | 5 |
| 1982-05-23 | @ CHA | 39 | W 6-4 | 16-23 | 7 | 19,577 | Rick Sutcliffe | Dennis Lamp | Dan Spillner | Jerry Koosman | | 199 | 192 | 7 |
| 1982-05-24 | @ MIN | 40 | W 9-2 | 17-23 | 6 | 5,515 | Len Barker | Pete Redfern | Len Barker | Pete Redfern | | 208 | 194 | 14 |
| 1982-05-25 | @ MIN | 41 | W 7-0 | 18-23 | 6 | 5,665 | Lary Sorensen | Brad Havens | Lary Sorensen | Brad Havens | | 215 | 194 | 21 |
| 1982-05-26 | @ MIN | 42 | W 2-1 | 19-23 | 6 | 5,188 | Rick Waits | Darrell Jackson | Dan Spillner | Ron Davis | | 217 | 195 | 22 |
| 1982-05-28 | vs CHA | 43 | W 5-2 | 20-23 | 6 | 25,105 | John Denny | Steve Trout | John Denny | Steve Trout | | 222 | 197 | 25 |
| 1982-05-29 | vs CHA | 44 | W 5-2 | 21-23 | 5 | 17,282 | Rick Sutcliffe | LaMarr Hoyt | Rick Sutcliffe | LaMarr Hoyt | Dan Spillner | 227 | 199 | 28 |
| 1982-05-30 | vs CHA | 45 | W 4-2 | 22-23 | 4 | 13,892 | Len Barker | Dennis Lamp | Len Barker | Dennis Lamp | | 231 | 201 | 30 |
| 1982-05-31 | vs MIN | 46 | W 9-4 | 23-23 | 4 | 14,690 | Lary Sorensen | Pete Filson | Lary Sorensen | Pete Filson | | 240 | 205 | 35 |
| 1982-06-01 | vs MIN | 47 | W 6-4 | 24-23 | 4 | 4,045 | Rick Waits | Darrell Jackson | Ed Glynn | Ron Davis | Dan Spillner | 246 | 209 | 37 |
| 1982-06-02 | vs MIN | 48 | W 4-2 | 25-23 | 4 | 11,495 | Rick Sutcliffe | Bobby Castillo | Rick Sutcliffe | Bobby Castillo | Ed Whitson | 250 | 211 | 39 |
| 1982-06-04 | @ TOR | 49 | W 6-3 | 26-23 | 3 | 12,371 | Len Barker | Jim Gott | Len Barker | Dale Murray | Dan Spillner | 256 | 214 | 42 |
| 1982-06-06 | @ TOR | 50 | L 1-5 | 27-24 | 3 | 0 | Lary Sorensen | Dave Stieb | Dave Stieb | Lary Sorensen | | 257 | 219 | 38 |
| 1982-06-06 | @ TOR | 51 | W 7-5 | 27-24 | 3 | 17,131 | Rick Waits | Jim Clancy | Ed Glynn | Jerry Garvin | Dan Spillner | 264 | 224 | 40 |
| 1982-06-07 | @ TOR | 52 | L 3-7 | 27-25 | 3 | 11,150 | John Denny | Luis Leal | Luis Leal | John Denny | | 267 | 231 | 36 |
| 1982-06-08 | @ DET | 53 | L 3-8 | 27-26 | 4 | 21,308 | Rick Sutcliffe | Pat Underwood | Pat Underwood | Rick Sutcliffe | | 270 | 239 | 31 |
| 1982-06-09 | @ DET | 54 | L 1-2 | 27-28 | 5 | 0 | Len Barker | Jack Morris | Jack Morris | Len Barker | | 271 | 241 | 30 |
| 1982-06-09 | @ DET | 55 | L 3-4 | 27-28 | 5 | 32,213 | Tom Brennan | Jerry Ujdur | Larry Pashnick | Bud Anderson | | 274 | 245 | 29 |
| 1982-06-11 | @ BOS | 56 | L 2-6 | 27-29 | 5 | 30,846 | Lary Sorensen | Bob Ojeda | Tom Burgmeier | Lary Sorensen | | 276 | 251 | 25 |
| 1982-06-12 | @ BOS | 57 | L 4-6 | 27-30 | 5 | 30,531 | John Denny | Mike Torrez | Bob Stanley | John Denny | | 280 | 257 | 23 |
| 1982-06-14 | vs DET | 58 | W 5-0 | 29-30 | 5 | 0 | Len Barker | Jack Morris | Len Barker | Jack Morris | | 285 | 257 | 28 |
| 1982-06-14 | vs DET | 59 | W 2-1 | 29-30 | 5 | 27,098 | Rick Sutcliffe | Jerry Ujdur | Rick Sutcliffe | Jerry Ujdur | Dan Spillner | 287 | 258 | 29 |
| 1982-06-17 | vs BOS | 60 | L 3-6 | 29-31 | 6 | 12,824 | Lary Sorensen | Mike Torrez | Mike Torrez | Lary Sorensen | Mark Clear | 290 | 264 | 26 |
| 1982-06-18 | vs BOS | 61 | W 10-3 | 30-31 | 5 | 16,618 | John Denny | Dennis Eckersley | John Denny | Dennis Eckersley | | 300 | 267 | 33 |
| 1982-06-19 | vs BOS | 62 | L 3-7 | 30-32 | 6 | 18,744 | Rick Sutcliffe | Chuck Rainey | Chuck Rainey | Rick Sutcliffe | Bob Stanley | 303 | 274 | 29 |
| 1982-06-20 | vs BOS | 63 | W 5-4 | 31-32 | 5 | 26,571 | Len Barker | Bruce Hurst | Dan Spillner | Luis Aponte | | 308 | 278 | 30 |
| 1982-06-21 | vs BAL | 64 | L 0-7 | 31-33 | 5 | 10,633 | Rick Waits | Dennis Martinez | Dennis Martinez | Rick Waits | | 308 | 285 | 23 |
| 1982-06-22 | vs BAL | 65 | W 8-6 | 32-33 | 5 | 7,400 | Lary Sorensen | Sammy Stewart | Lary Sorensen | Sammy Stewart | | 316 | 291 | 25 |
| 1982-06-23 | vs BAL | 66 | L 1-3 | 32-34 | 5 | 14,005 | John Denny | Jim Palmer | Jim Palmer | John Denny | Tim Stoddard | 317 | 294 | 23 |
| 1982-06-24 | @ NYA | 67 | W 5-2 | 33-34 | 5 | 23,449 | Rick Sutcliffe | Ron Guidry | Dan Spillner | Ron Guidry | | 322 | 296 | 26 |
| 1982-06-25 | @ NYA | 68 | L 3-11 | 33-35 | 5 | 21,948 | Len Barker | Tommy John | Tommy John | Len Barker | | 325 | 307 | 18 |
| 1982-06-26 | @ NYA | 69 | L 3-4 | 33-36 | 6 | 21,975 | Rick Waits | Dave Righetti | Dave LaRoche | Ed Whitson | | 328 | 311 | 17 |
| 1982-06-27 | @ NYA | 70 | W 4-3 | 34-36 | 5 | 55,521 | Lary Sorensen | Roger Erickson | Lary Sorensen | Roger Erickson | Rick Sutcliffe | 332 | 314 | 18 |
| 1982-06-29 | @ BAL | 71 | W 9-2 | 35-36 | 5 | 12,551 | John Denny | Scott McGregor | John Denny | Scott McGregor | | 341 | 316 | 25 |
| 1982-06-30 | @ BAL | 72 | W 9-0 | 36-36 | 5 | 14,259 | Rick Sutcliffe | Mike Flanagan | Rick Sutcliffe | Mike Flanagan | | 350 | 316 | 34 |
| 1982-07-01 | @ BAL | 73 | W 6-2 | 37-36 | 5 | 23,642 | Len Barker | Dennis Martinez | Len Barker | Dennis Martinez | Dan Spillner | 356 | 318 | 38 |
| 1982-07-02 | vs NYA | 74 | L 1-3 | 37-37 | 5 | 31,735 | Rick Waits | Roger Erickson | Roger Erickson | Rick Waits | Rich Gossage | 357 | 321 | 36 |
| 1982-07-03 | vs NYA | 75 | L 6-10 | 37-38 | 5 | 69,557 | Lary Sorensen | Tommy John | George Frazier | Dan Spillner | Rich Gossage | 363 | 331 | 32 |
| 1982-07-04 | vs NYA | 76 | L 2-3 | 37-39 | 6 | 22,652 | John Denny | Ron Guidry | George Frazier | John Denny | Roger Erickson | 365 | 334 | 31 |
| 1982-07-05 | @ OAK | 77 | L 0-2 | 37-40 | 6 | 15,083 | Rick Sutcliffe | Tom Underwood | Tom Underwood | Rick Sutcliffe | Dave Beard | 365 | 336 | 29 |
| 1982-07-06 | @ OAK | 78 | L 3-7 | 37-41 | 6 | 12,073 | Len Barker | Brian Kingman | Brian Kingman | Len Barker | | 368 | 343 | 25 |
| 1982-07-07 | @ CAL | 79 | W 8-6 | 38-41 | 6 | 25,288 | Rick Waits | Mike Witt | Rick Waits | Mike Witt | Dan Spillner | 376 | 349 | 27 |
| 1982-07-08 | @ CAL | 80 | L 1-5 | 38-42 | 6 | 23,374 | Lary Sorensen | Dave Goltz | Dave Goltz | Lary Sorensen | Doug Corbett | 377 | 354 | 23 |
| 1982-07-09 | @ SEA | 81 | W 7-4 | 39-42 | 6 | 14,437 | John Denny | Floyd Bannister | John Denny | Floyd Bannister | Dan Spillner | 384 | 358 | 26 |
| 1982-07-10 | @ SEA | 82 | W 7-1 | 40-42 | 5 | 23,893 | Rick Sutcliffe | Jim Beattie | Rick Sutcliffe | Jim Beattie | | 391 | 359 | 32 |
| 1982-07-11 | @ SEA | 83 | W 4-3 | 41-42 | 5 | 11,645 | Len Barker | Gaylord Perry | Len Barker | Bill Caudill | | 395 | 362 | 33 |
| 1982-07-15 | vs CAL | 84 | L 2-8 | 41-43 | 5 | 10,375 | Rick Waits | Dave Goltz | Dave Goltz | Rick Waits | | 397 | 370 | 27 |
| 1982-07-16 | vs CAL | 85 | L 0-15 | 41-44 | 6 | 18,472 | John Denny | Ken Forsch | Ken Forsch | John Denny | | 397 | 385 | 12 |
| 1982-07-17 | vs CAL | 86 | W 10-4 | 42-44 | 6 | 19,831 | Rick Sutcliffe | Geoff Zahn | Ed Glynn | Doug Corbett | | 407 | 389 | 18 |
| 1982-07-18 | vs CAL | 87 | W 5-4 | 43-44 | 6 | 16,416 | Len Barker | Mike Witt | Ed Glynn | Doug Corbett | | 412 | 393 | 19 |
| 1982-07-19 | vs OAK | 88 | W 5-4 | 44-44 | 6 | 11,850 | Lary Sorensen | Steve McCatty | Dan Spillner | Dave Beard | | 417 | 397 | 20 |
| 1982-07-20 | vs OAK | 89 | L 4-6 | 44-45 | 6 | 9,257 | Rick Waits | Mike Norris | Mike Norris | Rick Waits | | 421 | 403 | 18 |
| 1982-07-21 | vs OAK | 90 | L 4-6 | 44-46 | 6 | 12,404 | John Denny | Tom Underwood | Tom Underwood | John Denny | Brian Kingman | 425 | 409 | 16 |
| 1982-07-23 | vs SEA | 91 | W 4-3 | 45-46 | 6 | 13,352 | Rick Sutcliffe | Gaylord Perry | Dan Spillner | Ed Vande Berg | | 429 | 412 | 17 |
| 1982-07-24 | vs SEA | 92 | L 0-9 | 45-47 | 6 | 27,583 | Len Barker | Mike Moore | Mike Moore | Len Barker | | 429 | 421 | 8 |
| 1982-07-25 | vs SEA | 93 | W 5-3 | 46-47 | 6 | 14,500 | Lary Sorensen | Jim Beattie | Lary Sorensen | Jim Beattie | Dan Spillner | 434 | 424 | 10 |
| 1982-07-26 | vs KCA | 94 | L 1-8 | 46-48 | 6 | 13,841 | Tom Brennan | Vida Blue | Vida Blue | Tom Brennan | | 435 | 432 | 3 |
| 1982-07-27 | vs KCA | 95 | L 1-8 | 46-49 | 6 | 8,908 | Rick Waits | Dave Frost | Dave Frost | Rick Waits | | 436 | 440 | -4 |
| 1982-07-28 | vs KCA | 96 | W 4-2 | 47-49 | 6 | 9,868 | Rick Sutcliffe | Paul Splittorff | Rick Sutcliffe | Bill Castro | Dan Spillner | 440 | 442 | -2 |
| 1982-07-29 | @ MIL | 97 | W 5-1 | 48-49 | 6 | 29,781 | Len Barker | Pete Vuckovich | Dan Spillner | Jim Slaton | | 445 | 443 | 2 |
| 1982-07-30 | @ MIL | 98 | W 7-2 | 49-49 | 6 | 27,103 | Lary Sorensen | Randy Lerch | Lary Sorensen | Randy Lerch | | 452 | 445 | 7 |
| 1982-07-31 | @ MIL | 99 | L 2-4 | 49-50 | 6 | 41,421 | Rick Waits | Mike Caldwell | Mike Caldwell | Rick Waits | Rollie Fingers | 454 | 449 | 5 |
| 1982-08-01 | @ MIL | 100 | W 4-1 | 50-51 | 6 | 0 | Ed Whitson | Moose Haas | Ed Whitson | Moose Haas | Dan Spillner | 458 | 450 | 8 |
| 1982-08-01 | @ MIL | 101 | L 2-7 | 50-51 | 6 | 41,891 | Bud Anderson | Jim Slaton | Jim Slaton | Bud Anderson | | 460 | 457 | 3 |
| 1982-08-02 | vs TEX | 102 | W 6-2 | 51-51 | 6 | 8,657 | Rick Sutcliffe | Frank Tanana | Rick Sutcliffe | Frank Tanana | | 466 | 459 | 7 |
| 1982-08-03 | vs TEX | 103 | W 2-0 | 52-52 | 5 | 0 | Len Barker | Dave J. Schmidt | Len Barker | Dave J. Schmidt | Dan Spillner | 468 | 459 | 9 |
| 1982-08-03 | vs TEX | 104 | L 4-5 | 52-52 | 5 | 19,754 | Lary Sorensen | John Butcher | Jon Matlack | Dan Spillner | Steve Comer | 472 | 464 | 8 |
| 1982-08-04 | vs TEX | 105 | W 8-4 | 53-52 | 5 | 7,168 | Rick Waits | Doc Medich | Bud Anderson | Doc Medich | | 480 | 468 | 12 |
| 1982-08-06 | vs MIL | 106 | L 2-5 | 53-53 | 5 | 18,243 | Ed Whitson | Moose Haas | Moose Haas | Ed Glynn | Rollie Fingers | 482 | 473 | 9 |
| 1982-08-07 | vs MIL | 107 | W 4-3 | 54-53 | 6 | 19,883 | Rick Sutcliffe | Bob McClure | Ed Glynn | Jim Slaton | | 486 | 476 | 10 |
| 1982-08-08 | vs MIL | 108 | L 6-7 | 54-54 | 6 | 32,337 | Len Barker | Pete Vuckovich | Dwight Bernard | Len Barker | Rollie Fingers | 492 | 483 | 9 |
| 1982-08-09 | @ KCA | 109 | L 2-12 | 54-55 | 6 | 40,044 | Lary Sorensen | Larry Gura | Larry Gura | Lary Sorensen | | 494 | 495 | -1 |
| 1982-08-10 | @ KCA | 110 | L 1-5 | 54-56 | 6 | 25,864 | Rick Waits | Vida Blue | Mike Armstrong | Rick Waits | | 495 | 500 | -5 |
| 1982-08-11 | @ KCA | 111 | L 0-8 | 54-57 | 7 | 27,540 | Ed Whitson | Paul Splittorff | Don Hood | Ed Whitson | | 495 | 508 | -13 |
| 1982-08-13 | @ TEX | 112 | L 7-8 | 54-58 | 6 | 13,691 | Rick Sutcliffe | Frank Tanana | Danny Darwin | Dan Spillner | | 502 | 516 | -14 |
| 1982-08-14 | @ TEX | 113 | L 2-3 | 54-59 | 7 | 35,019 | Len Barker | John Butcher | John Butcher | Len Barker | | 504 | 519 | -15 |
| 1982-08-15 | @ TEX | 114 | W 6-4 | 55-59 | 7 | 9,321 | Lary Sorensen | Charlie Hough | Lary Sorensen | Charlie Hough | Ed Glynn | 510 | 523 | -13 |
| 1982-08-16 | @ TOR | 115 | L 1-2 | 55-60 | 7 | 17,704 | Rick Waits | Jim Gott | Jim Gott | Rick Waits | Joey McLaughlin | 511 | 525 | -14 |
| 1982-08-17 | @ TOR | 116 | W 6-5 | 57-60 | 6 | 0 | Ed Whitson | Luis Leal | Dan Spillner | Joey McLaughlin | | 517 | 530 | -13 |
| 1982-08-17 | @ TOR | 117 | W 9-5 | 57-60 | 6 | 26,636 | Rick Sutcliffe | Dave Geisel | Rick Sutcliffe | Dave Geisel | | 526 | 535 | -9 |
| 1982-08-20 | vs MIN | 118 | W 7-5 | 58-60 | 6 | 11,066 | Len Barker | Brad Havens | Len Barker | Pete Redfern | Dan Spillner | 533 | 540 | -7 |
| 1982-08-21 | vs MIN | 119 | L 3-4 | 58-61 | 6 | 12,778 | Lary Sorensen | Albert Williams | Albert Williams | Lary Sorensen | Ron Davis | 536 | 544 | -8 |
| 1982-08-22 | vs MIN | 120 | W 4-3 | 59-61 | 6 | 10,929 | Rick Sutcliffe | Jack O'Connor | Rick Sutcliffe | Jack O'Connor | | 540 | 547 | -7 |
| 1982-08-23 | vs CHA | 121 | W 5-4 | 60-61 | 6 | 7,603 | Ed Whitson | Jim Siwy | Dan Spillner | Chico Escarrega | | 545 | 551 | -6 |
| 1982-08-24 | vs CHA | 122 | W 14-7 | 61-61 | 6 | 6,575 | John Denny | LaMarr Hoyt | Rick Waits | LaMarr Hoyt | Tom Brennan | 559 | 558 | 1 |
| 1982-08-25 | vs CHA | 123 | L 1-5 | 61-62 | 6 | 8,461 | Len Barker | Richard Dotson | Richard Dotson | Len Barker | Sparky Lyle | 560 | 563 | -3 |
| 1982-08-27 | @ MIN | 124 | L 3-5 | 61-63 | 6 | 6,638 | Lary Sorensen | Albert Williams | Albert Williams | Lary Sorensen | Ron Davis | 563 | 568 | -5 |
| 1982-08-28 | @ MIN | 125 | L 0-10 | 61-64 | 6 | 10,458 | Rick Sutcliffe | Jack O'Connor | Jack O'Connor | Rick Sutcliffe | | 563 | 578 | -15 |
| 1982-08-29 | @ MIN | 126 | L 3-6 | 61-65 | 6 | 8,926 | Ed Whitson | Bobby Castillo | Bobby Castillo | Dan Spillner | | 566 | 584 | -18 |
| 1982-08-30 | @ CHA | 127 | L 1-4 | 61-66 | 6 | 14,322 | Rick Waits | Richard Dotson | Richard Dotson | Rick Waits | Jim Kern | 567 | 588 | -21 |
| 1982-08-31 | @ CHA | 128 | L 6-14 | 61-67 | 6 | 9,058 | Len Barker | Dennis Lamp | Kevin Hickey | Len Barker | | 573 | 602 | -29 |
| 1982-09-01 | @ CHA | 129 | L 0-6 | 61-68 | 6 | 8,797 | Lary Sorensen | Jerry Koosman | Jerry Koosman | Lary Sorensen | | 573 | 608 | -35 |
| 1982-09-02 | @ MIL | 130 | L 1-2 | 62-69 | 6 | 0 | Rick Sutcliffe | Moose Haas | Moose Haas | Rick Sutcliffe | Pete Ladd | 574 | 610 | -36 |
| 1982-09-02 | @ MIL | 131 | W 4-2 | 62-69 | 6 | 18,056 | Ed Whitson | Don Sutton | Dan Spillner | Don Sutton | | 578 | 612 | -34 |
| 1982-09-03 | vs TOR | 132 | W 3-2 | 63-69 | 6 | 12,131 | Bud Anderson | Jim Clancy | Bud Anderson | Jim Clancy | Tom Brennan | 581 | 614 | -33 |
| 1982-09-04 | vs TOR | 133 | W 4-3 | 64-69 | 6 | 6,110 | John Denny | Mark Eichhorn | Tom Brennan | Dale Murray | Dan Spillner | 585 | 617 | -32 |
| 1982-09-05 | vs TOR | 134 | L 5-6 | 64-70 | 6 | 6,968 | Len Barker | Luis Leal | Luis Leal | Len Barker | Dale Murray | 590 | 623 | -33 |
| 1982-09-06 | vs BOS | 135 | L 3-10 | 64-71 | 6 | 37,699 | Lary Sorensen | Mike Torrez | Mike Torrez | Lary Sorensen | Bob Stanley | 593 | 633 | -40 |
| 1982-09-07 | vs BOS | 136 | W 5-4 | 65-71 | 6 | 4,219 | Rick Sutcliffe | Brian Denman | Dan Spillner | Mark Clear | | 598 | 637 | -39 |
| 1982-09-08 | vs BOS | 137 | W 2-0 | 66-71 | 6 | 4,907 | Ed Whitson | John Tudor | Ed Whitson | John Tudor | | 600 | 637 | -37 |
| 1982-09-09 | vs BAL | 138 | W 3-0 | 67-71 | 6 | 4,279 | John Denny | Dennis Martinez | Bud Anderson | Dennis Martinez | | 603 | 637 | -34 |
| 1982-09-10 | vs BAL | 139 | L 2-3 | 67-72 | 6 | 8,374 | Len Barker | Scott McGregor | Sammy Stewart | Dan Spillner | | 605 | 640 | -35 |
| 1982-09-11 | vs BAL | 140 | L 1-8 | 67-73 | 6 | 8,827 | Lary Sorensen | Mike Flanagan | Mike Flanagan | Lary Sorensen | | 606 | 648 | -42 |
| 1982-09-12 | vs BAL | 141 | W 3-0 | 68-73 | 6 | 7,860 | Rick Sutcliffe | Jim Palmer | Rick Sutcliffe | Tippy Martinez | | 609 | 648 | -39 |
| 1982-09-13 | @ BOS | 142 | W 3-1 | 70-73 | 6 | 0 | Ed Whitson | Oil Can Boyd | Ed Whitson | Oil Can Boyd | Dan Spillner | 612 | 649 | -37 |
| 1982-09-13 | @ BOS | 143 | W 4-3 | 70-73 | 6 | 19,717 | Bud Anderson | Chuck Rainey | Tom Brennan | Luis Aponte | | 616 | 652 | -36 |
| 1982-09-14 | @ BOS | 144 | L 1-12 | 70-74 | 6 | 15,765 | Neal Heaton | John Tudor | John Tudor | Neal Heaton | | 617 | 664 | -47 |
| 1982-09-15 | @ BOS | 145 | W 7-4 | 71-74 | 6 | 15,264 | Len Barker | Dennis Eckersley | Len Barker | Dennis Eckersley | Dan Spillner | 624 | 668 | -44 |
| 1982-09-17 | @ BAL | 146 | W 5-3 | 72-74 | 6 | 14,924 | Rick Sutcliffe | Dennis Martinez | Rick Sutcliffe | Dennis Martinez | Ed Glynn | 629 | 671 | -42 |
| 1982-09-18 | @ BAL | 147 | L 2-5 | 72-75 | 6 | 23,172 | Bud Anderson | Scott McGregor | Scott McGregor | Bud Anderson | | 631 | 676 | -45 |
| 1982-09-19 | @ BAL | 148 | L 2-4 | 72-76 | 6 | 41,127 | Neal Heaton | Mike Flanagan | Mike Flanagan | Ed Glynn | | 633 | 680 | -47 |
| 1982-09-21 | @ NYA | 149 | W 9-8 | 73-77 | 6 | 0 | Len Barker | Ron Guidry | Jerry Reed | Rudy May | Ed Glynn | 642 | 688 | -46 |
| 1982-09-21 | @ NYA | 150 | L 2-6 | 73-77 | 6 | 15,339 | Lary Sorensen | Dave Righetti | Dave Righetti | Lary Sorensen | | 644 | 694 | -50 |
| 1982-09-22 | @ NYA | 151 | W 5-0 | 74-77 | 5 | 16,922 | Rick Sutcliffe | Doyle Alexander | Rick Sutcliffe | Doyle Alexander | | 649 | 694 | -45 |
| 1982-09-24 | @ DET | 152 | W 6-2 | 75-77 | 5 | 7,226 | Tom Brennan | Jerry Ujdur | Tom Brennan | Jerry Ujdur | Dan Spillner | 655 | 696 | -41 |
| 1982-09-25 | @ DET | 153 | L 0-4 | 75-78 | 5 | 8,358 | Neal Heaton | Jack Morris | Jack Morris | Neal Heaton | | 655 | 700 | -45 |
| 1982-09-26 | @ DET | 154 | W 4-3 | 76-78 | 5 | 8,613 | Len Barker | Milt Wilcox | Len Barker | Milt Wilcox | Ed Glynn | 659 | 703 | -44 |
| 1982-09-28 | vs NYA | 155 | L 4-6 | 76-79 | 6 | 5,017 | Rick Sutcliffe | Doyle Alexander | Doyle Alexander | Rick Sutcliffe | Rich Gossage | 663 | 709 | -46 |
| 1982-09-29 | vs NYA | 156 | L 6-13 | 76-80 | 6 | 6,868 | Lary Sorensen | Jay Howell | Jay Howell | Lary Sorensen | George Frazier | 669 | 722 | -53 |
| 1982-09-30 | vs NYA | 157 | L 5-7 | 76-81 | 6 | 6,358 | Neal Heaton | Shane Rawley | Mike Morgan | Dan Spillner | Rich Gossage | 674 | 729 | -55 |
| 1982-10-01 | vs DET | 158 | W 3-2 | 77-82 | 6 | 0 | Len Barker | Milt Wilcox | Len Barker | Milt Wilcox | | 677 | 731 | -54 |
| 1982-10-01 | vs DET | 159 | L 2-4 | 77-82 | 6 | 6,075 | Bud Anderson | Pat Underwood | Pat Underwood | Bud Anderson | Howard Bailey | 679 | 735 | -56 |
| 1982-10-02 | vs DET | 160 | W 2-0 | 78-83 | 6 | 0 | Tom Brennan | Dan Petry | Tom Brennan | Dan Petry | Dan Spillner | 681 | 735 | -54 |
| 1982-10-02 | vs DET | 161 | L 1-4 | 78-83 | 6 | 7,151 | Jerry Reed | Dave Rucker | Dave Rucker | Jerry Reed | | 682 | 739 | -57 |
| 1982-10-03 | vs DET | 162 | L 1-9 | 78-84 | 6 | 7,934 | Rick Sutcliffe | Jerry Ujdur | Jerry Ujdur | Rick Sutcliffe | | 683 | 748 | -65 |