| 1982-04-05 | vs CHN | 1 | L 2-3 | 0-1 | 2 | 51,894 | Mario Soto | Doug Bird | Doug Bird | Mario Soto | Guillermo Hernandez | 2 | 3 | -1 |
| 1982-04-07 | vs CHN | 2 | W 6-2 | 1-1 | 3 | 10,158 | Bruce Berenyi | Dickie Noles | Bruce Berenyi | Dickie Noles | Tom Hume | 8 | 5 | 3 |
| 1982-04-09 | vs SFN | 3 | W 7-0 | 2-1 | 2 | 10,069 | Frank Pastore | Dan Schatzeder | Frank Pastore | Dan Schatzeder | | 15 | 5 | 10 |
| 1982-04-10 | vs SFN | 4 | L 5-7 | 2-2 | 3 | 11,906 | Mario Soto | Rich Gale | Greg Minton | Tom Hume | Jim Barr | 20 | 12 | 8 |
| 1982-04-11 | vs SFN | 5 | L 1-6 | 2-3 | 3 | 11,205 | Charlie Leibrandt | Al Holland | Al Holland | Charlie Leibrandt | | 21 | 18 | 3 |
| 1982-04-12 | vs ATL | 6 | L 1-6 | 2-4 | 5 | 11,451 | Bruce Berenyi | Bob Walk | Bob Walk | Bruce Berenyi | | 22 | 24 | -2 |
| 1982-04-13 | vs ATL | 7 | L 5-8 | 2-5 | 5 | 11,846 | Bob Shirley | Joe Cowley | Gene Garber | Jim Kern | | 27 | 32 | -5 |
| 1982-04-14 | vs ATL | 8 | L 2-5 | 2-6 | 6 | 14,217 | Frank Pastore | Tommy Boggs | Rick Camp | Jim Kern | | 29 | 37 | -8 |
| 1982-04-16 | @ SFN | 9 | L 1-6 | 2-7 | 6 | 10,201 | Mario Soto | Rich Gale | Rich Gale | Mario Soto | | 30 | 43 | -13 |
| 1982-04-17 | @ SFN | 10 | W 8-2 | 3-7 | 6 | 11,605 | Bruce Berenyi | Al Holland | Bruce Berenyi | Al Holland | Tom Hume | 38 | 45 | -7 |
| 1982-04-18 | @ SFN | 11 | L 2-4 | 3-8 | 6 | 39,154 | Tom Seaver | Alan Fowlkes | Alan Fowlkes | Tom Seaver | Greg Minton | 40 | 49 | -9 |
| 1982-04-20 | @ ATL | 12 | L 2-4 | 3-9 | 6 | 37,268 | Frank Pastore | Tommy Boggs | Steve Bedrosian | Frank Pastore | Gene Garber | 42 | 53 | -11 |
| 1982-04-21 | @ ATL | 13 | L 3-4 | 3-10 | 6 | 22,153 | Mario Soto | Rick Mahler | Rick Camp | Bob Shirley | | 45 | 57 | -12 |
| 1982-04-22 | @ ATL | 14 | W 2-1 | 4-10 | 6 | 20,701 | Bruce Berenyi | Bob Walk | Bruce Berenyi | Bob Walk | Tom Hume | 47 | 58 | -11 |
| 1982-04-23 | @ HOU | 15 | L 3-7 | 4-11 | 6 | 23,452 | Tom Seaver | Joe Niekro | Joe Niekro | Tom Seaver | | 50 | 65 | -15 |
| 1982-04-24 | @ HOU | 16 | W 3-2 | 5-11 | 6 | 32,525 | Frank Pastore | Bob Knepper | Frank Pastore | Bob Knepper | Tom Hume | 53 | 67 | -14 |
| 1982-04-25 | @ HOU | 17 | W 4-3 | 6-11 | 5 | 20,270 | Mario Soto | Don Sutton | Bob Shirley | Randy Moffitt | Tom Hume | 57 | 70 | -13 |
| 1982-04-27 | @ CHN | 18 | W 6-3 | 7-11 | 5 | 3,743 | Bruce Berenyi | Dan Larson | Bruce Berenyi | Dan Larson | Jim Kern | 63 | 73 | -10 |
| 1982-04-28 | @ CHN | 19 | L 0-6 | 7-12 | 6 | 5,335 | Tom Seaver | Dickie Noles | Dickie Noles | Tom Seaver | | 63 | 79 | -16 |
| 1982-04-30 | vs SLN | 20 | W 8-2 | 8-12 | 5 | 18,864 | Frank Pastore | Joaquin Andujar | Frank Pastore | Joaquin Andujar | | 71 | 81 | -10 |
| 1982-05-01 | vs SLN | 21 | W 10-1 | 9-12 | 5 | 21,193 | Mario Soto | Andy Rincon | Mario Soto | Andy Rincon | | 81 | 82 | -1 |
| 1982-05-02 | vs SLN | 22 | W 5-1 | 10-13 | 6 | 0 | Charlie Leibrandt | Steve Mura | Charlie Leibrandt | Steve Mura | | 86 | 83 | 3 |
| 1982-05-02 | vs SLN | 23 | L 4-6 | 10-13 | 6 | 26,083 | Joe Price | John Martin | John Martin | Joe Price | Bruce Sutter | 90 | 89 | 1 |
| 1982-05-04 | vs HOU | 24 | W 5-2 | 11-13 | 4 | 15,119 | Tom Seaver | Bob Knepper | Tom Seaver | Bob Knepper | Tom Hume | 95 | 91 | 4 |
| 1982-05-05 | vs HOU | 25 | L 7-8 | 11-14 | 5 | 17,691 | Frank Pastore | Don Sutton | Don Sutton | Frank Pastore | Dave Smith | 102 | 99 | 3 |
| 1982-05-07 | vs PIT | 26 | W 5-0 | 12-14 | 4 | 16,465 | Mario Soto | Paul Moskau | Mario Soto | Paul Moskau | | 107 | 99 | 8 |
| 1982-05-08 | vs PIT | 27 | L 2-4 | 12-15 | 5 | 19,626 | Bruce Berenyi | Eddie Solomon | Manny Sarmiento | Bob Shirley | | 109 | 103 | 6 |
| 1982-05-09 | vs PIT | 28 | L 3-6 | 12-16 | 5 | 21,416 | Tom Seaver | Don Robinson | Don Robinson | Tom Seaver | Kent Tekulve | 112 | 109 | 3 |
| 1982-05-10 | @ SLN | 29 | W 3-1 | 13-16 | 4 | 15,421 | Frank Pastore | John Martin | Frank Pastore | John Martin | Tom Hume | 115 | 110 | 5 |
| 1982-05-11 | @ SLN | 30 | L 1-5 | 13-17 | 6 | 16,743 | Mario Soto | Steve Mura | Steve Mura | Mario Soto | Doug Bair | 116 | 115 | 1 |
| 1982-05-13 | @ PIT | 31 | W 2-1 | 14-17 | 5 | 7,354 | Bruce Berenyi | John Candelaria | Joe Price | Rod Scurry | Tom Hume | 118 | 116 | 2 |
| 1982-05-14 | @ PIT | 32 | L 7-8 | 14-18 | 5 | 15,271 | Tom Seaver | Don Robinson | Enrique Romo | Jim Kern | Kent Tekulve | 125 | 124 | 1 |
| 1982-05-15 | @ PIT | 33 | L 9-12 | 14-19 | 6 | 11,184 | Frank Pastore | Rick Rhoden | Rick Rhoden | Frank Pastore | | 134 | 136 | -2 |
| 1982-05-16 | @ PIT | 34 | W 3-1 | 15-19 | 4 | 21,561 | Mario Soto | Eddie Solomon | Mario Soto | Eddie Solomon | | 137 | 137 | 0 |
| 1982-05-17 | @ NYN | 35 | W 7-2 | 16-19 | 4 | 14,131 | Charlie Leibrandt | Pete Falcone | Charlie Leibrandt | Pete Falcone | | 144 | 139 | 5 |
| 1982-05-18 | @ NYN | 36 | L 4-7 | 16-20 | 5 | 15,303 | Bruce Berenyi | Randy Jones | Randy Jones | Bruce Berenyi | Neil Allen | 148 | 146 | 2 |
| 1982-05-19 | @ NYN | 37 | L 2-4 | 16-21 | 5 | 16,790 | Tom Seaver | Pat Zachry | Pat Zachry | Tom Seaver | | 150 | 150 | 0 |
| 1982-05-21 | vs MON | 38 | L 0-2 | 16-22 | 6 | 15,135 | Mario Soto | Charlie Lea | Charlie Lea | Mario Soto | Woodie Fryman | 150 | 152 | -2 |
| 1982-05-22 | vs MON | 39 | L 2-4 | 16-23 | 6 | 27,293 | Frank Pastore | Scott Sanderson | Scott Sanderson | Frank Pastore | Woodie Fryman | 152 | 156 | -4 |
| 1982-05-23 | vs MON | 40 | L 2-4 | 16-24 | 6 | 18,518 | Bruce Berenyi | Steve Rogers | Steve Rogers | Bruce Berenyi | Jeff Reardon | 154 | 160 | -6 |
| 1982-05-24 | vs PHI | 41 | L 1-9 | 16-25 | 6 | 17,110 | Tom Seaver | Steve Carlton | Steve Carlton | Tom Seaver | | 155 | 169 | -14 |
| 1982-05-25 | vs PHI | 42 | W 4-3 | 17-25 | 6 | 16,688 | Greg Harris | Larry Christenson | Greg Harris | Ed Farmer | Tom Hume | 159 | 172 | -13 |
| 1982-05-26 | vs PHI | 43 | W 2-0 | 18-25 | 5 | 14,091 | Mario Soto | Mike Krukow | Mario Soto | Mike Krukow | | 161 | 172 | -11 |
| 1982-05-28 | @ MON | 44 | L 2-4 | 18-26 | 6 | 31,058 | Bruce Berenyi | Scott Sanderson | Scott Sanderson | Bruce Berenyi | | 163 | 176 | -13 |
| 1982-05-29 | @ MON | 45 | L 1-4 | 18-27 | 6 | 28,037 | Tom Seaver | Steve Rogers | Steve Rogers | Joe Price | | 164 | 180 | -16 |
| 1982-05-30 | @ MON | 46 | W 7-3 | 19-27 | 6 | 42,944 | Frank Pastore | Bill Gullickson | Bob Shirley | Bill Gullickson | Charlie Leibrandt | 171 | 183 | -12 |
| 1982-05-31 | @ PHI | 47 | L 4-5 | 19-28 | 6 | 22,708 | Mario Soto | Larry Christenson | Sid Monge | Bob Shirley | | 175 | 188 | -13 |
| 1982-06-01 | @ PHI | 48 | W 4-1 | 20-28 | 6 | 20,102 | Greg Harris | Mike Krukow | Greg Harris | Mike Krukow | | 179 | 189 | -10 |
| 1982-06-02 | @ PHI | 49 | L 2-4 | 20-29 | 6 | 22,960 | Bruce Berenyi | Dick Ruthven | Dick Ruthven | Bruce Berenyi | Warren Brusstar | 181 | 193 | -12 |
| 1982-06-04 | vs NYN | 50 | W 8-3 | 21-29 | 6 | 13,319 | Tom Seaver | Mike Scott | Tom Seaver | Mike Scott | | 189 | 196 | -7 |
| 1982-06-05 | vs NYN | 51 | W 6-2 | 22-29 | 6 | 20,286 | Mario Soto | Charlie Puleo | Mario Soto | Charlie Puleo | | 195 | 198 | -3 |
| 1982-06-06 | vs NYN | 52 | L 3-6 | 22-30 | 6 | 24,053 | Frank Pastore | Craig Swan | Craig Swan | Frank Pastore | Neil Allen | 198 | 204 | -6 |
| 1982-06-07 | @ SDN | 53 | L 5-6 | 22-31 | 6 | 11,832 | Greg Harris | Chris Welsh | Chris Welsh | Greg Harris | Luis DeLeon | 203 | 210 | -7 |
| 1982-06-08 | @ SDN | 54 | L 1-4 | 22-32 | 6 | 13,111 | Bruce Berenyi | John Montefusco | John Montefusco | Bruce Berenyi | Luis DeLeon | 204 | 214 | -10 |
| 1982-06-09 | @ SDN | 55 | W 4-3 | 23-32 | 6 | 15,355 | Tom Seaver | Juan Eichelberger | Tom Seaver | Juan Eichelberger | Tom Hume | 208 | 217 | -9 |
| 1982-06-10 | @ LAN | 56 | W 3-2 | 24-32 | 6 | 47,142 | Mario Soto | Fernando Valenzuela | Jim Kern | Fernando Valenzuela | Tom Hume | 211 | 219 | -8 |
| 1982-06-11 | @ LAN | 57 | L 1-11 | 24-33 | 6 | 37,586 | Frank Pastore | Jerry Reuss | Jerry Reuss | Frank Pastore | | 212 | 230 | -18 |
| 1982-06-12 | @ LAN | 58 | L 3-4 | 24-34 | 6 | 47,080 | Greg Harris | Bob Welch | Bob Welch | Greg Harris | Steve Howe | 215 | 234 | -19 |
| 1982-06-13 | @ LAN | 59 | W 4-2 | 25-34 | 5 | 45,763 | Bruce Berenyi | Burt Hooton | Bruce Berenyi | Burt Hooton | Tom Hume | 219 | 236 | -17 |
| 1982-06-15 | vs SFN | 60 | L 3-4 | 25-35 | 6 | 21,416 | Tom Seaver | Bill Laskey | Bill Laskey | Tom Seaver | Gary Lavelle | 222 | 240 | -18 |
| 1982-06-16 | vs SFN | 61 | W 7-3 | 26-35 | 5 | 18,127 | Mario Soto | Mike Chris | Mario Soto | Jim Barr | Tom Hume | 229 | 243 | -14 |
| 1982-06-17 | vs SFN | 62 | W 4-2 | 27-35 | 5 | 18,808 | Charlie Leibrandt | Rich Gale | Charlie Leibrandt | Rich Gale | Tom Hume | 233 | 245 | -12 |
| 1982-06-18 | vs LAN | 63 | L 2-3 | 27-36 | 5 | 23,958 | Greg Harris | Dave Stewart | Terry Forster | Tom Hume | Vicente Romo | 235 | 248 | -13 |
| 1982-06-19 | vs LAN | 64 | L 1-2 | 27-37 | 5 | 27,236 | Bruce Berenyi | Fernando Valenzuela | Fernando Valenzuela | Bruce Berenyi | | 236 | 250 | -14 |
| 1982-06-20 | vs LAN | 65 | L 2-4 | 27-38 | 6 | 25,968 | Tom Seaver | Jerry Reuss | Jerry Reuss | Tom Seaver | Steve Howe | 238 | 254 | -16 |
| 1982-06-21 | vs LAN | 66 | W 10-2 | 28-38 | 5 | 17,901 | Mario Soto | Bob Welch | Mario Soto | Bob Welch | | 248 | 256 | -8 |
| 1982-06-22 | vs SDN | 67 | W 7-5 | 29-38 | 5 | 14,101 | Charlie Leibrandt | Tim Lollar | Joe Price | Gary Lucas | Tom Hume | 255 | 261 | -6 |
| 1982-06-23 | vs SDN | 68 | W 5-4 | 30-38 | 5 | 14,004 | Frank Pastore | Chris Welsh | Tom Hume | Eric Show | | 260 | 265 | -5 |
| 1982-06-24 | vs SDN | 69 | L 6-7 | 30-39 | 5 | 14,490 | Greg Harris | John Montefusco | Eric Show | Bob Shirley | | 266 | 272 | -6 |
| 1982-06-25 | vs ATL | 70 | L 2-5 | 30-40 | 5 | 20,263 | Bruce Berenyi | Phil Niekro | Phil Niekro | Bruce Berenyi | Gene Garber | 268 | 277 | -9 |
| 1982-06-26 | vs ATL | 71 | W 2-1 | 31-40 | 5 | 26,561 | Tom Seaver | Ken Dayley | Tom Seaver | Ken Dayley | Tom Hume | 270 | 278 | -8 |
| 1982-06-27 | vs ATL | 72 | L 0-2 | 31-41 | 5 | 31,000 | Mario Soto | Rick Camp | Gene Garber | Tom Hume | Al Hrabosky | 270 | 280 | -10 |
| 1982-06-28 | @ SFN | 73 | L 1-7 | 31-42 | 5 | 10,867 | Charlie Leibrandt | Renie Martin | Renie Martin | Charlie Leibrandt | | 271 | 287 | -16 |
| 1982-06-29 | @ SFN | 74 | L 0-3 | 31-43 | 5 | 4,394 | Bob Shirley | Atlee Hammaker | Atlee Hammaker | Bob Shirley | | 271 | 290 | -19 |
| 1982-06-30 | @ SFN | 75 | L 6-7 | 31-44 | 5 | 4,358 | Bruce Berenyi | Bill Laskey | Greg Minton | Charlie Leibrandt | | 277 | 297 | -20 |
| 1982-07-02 | @ ATL | 76 | L 4-6 | 31-45 | 6 | 32,709 | Tom Seaver | Rick Camp | Ken Dayley | Tom Seaver | Gene Garber | 281 | 303 | -22 |
| 1982-07-03 | @ ATL | 77 | L 2-4 | 31-46 | 6 | 38,103 | Mario Soto | Rick Mahler | Rick Mahler | Mario Soto | Gene Garber | 283 | 307 | -24 |
| 1982-07-04 | @ ATL | 78 | L 1-4 | 31-47 | 6 | 48,905 | Bob Shirley | Bob Walk | Bob Walk | Bob Shirley | Steve Bedrosian | 284 | 311 | -27 |
| 1982-07-05 | vs SLN | 79 | L 5-6 | 31-48 | 6 | 22,562 | Bruce Berenyi | Bob Forsch | Jim Kaat | Tom Hume | Doug Bair | 289 | 317 | -28 |
| 1982-07-06 | vs SLN | 80 | L 1-3 | 31-49 | 6 | 17,026 | Charlie Leibrandt | Steve Mura | Steve Mura | Charlie Leibrandt | | 290 | 320 | -30 |
| 1982-07-07 | @ PIT | 81 | W 6-3 | 32-49 | 6 | 20,024 | Tom Seaver | John Candelaria | Tom Hume | Kent Tekulve | Greg Harris | 296 | 323 | -27 |
| 1982-07-08 | @ PIT | 82 | L 8-9 | 32-50 | 6 | 9,950 | Mario Soto | Manny Sarmiento | Kent Tekulve | Joe Price | | 304 | 332 | -28 |
| 1982-07-09 | @ CHN | 83 | L 0-12 | 32-51 | 6 | 14,891 | Bob Shirley | Fergie Jenkins | Fergie Jenkins | Bob Shirley | | 304 | 344 | -40 |
| 1982-07-10 | @ CHN | 84 | L 0-1 | 33-52 | 6 | 0 | Bruce Berenyi | Dickie Noles | Dickie Noles | Bruce Berenyi | | 304 | 345 | -41 |
| 1982-07-10 | @ CHN | 85 | W 6-5 | 33-52 | 6 | 20,294 | Charlie Leibrandt | Ken Kravec | Mario Soto | Mike Proly | | 310 | 350 | -40 |
| 1982-07-11 | @ CHN | 86 | L 2-9 | 33-53 | 6 | 20,307 | Tom Seaver | Doug Bird | Doug Bird | Tom Seaver | | 312 | 359 | -47 |
| 1982-07-15 | @ SLN | 87 | W 7-3 | 34-53 | 6 | 27,913 | Bruce Berenyi | John Stuper | Bruce Berenyi | John Stuper | Jim Kern | 319 | 362 | -43 |
| 1982-07-16 | @ SLN | 88 | L 4-6 | 34-54 | 6 | 23,637 | Bob Shirley | Steve Mura | Jeff Lahti | Tom Hume | Bruce Sutter | 323 | 368 | -45 |
| 1982-07-17 | @ SLN | 89 | L 2-4 | 34-55 | 6 | 22,318 | Mario Soto | Bob Forsch | Bob Forsch | Mario Soto | Doug Bair | 325 | 372 | -47 |
| 1982-07-18 | @ SLN | 90 | L 5-6 | 34-56 | 6 | 21,336 | Charlie Leibrandt | Dave LaPoint | Jim Kaat | Charlie Leibrandt | Bruce Sutter | 330 | 378 | -48 |
| 1982-07-19 | vs PIT | 91 | L 4-5 | 34-57 | 6 | 16,395 | Frank Pastore | Ross Baumgarten | Manny Sarmiento | Frank Pastore | Kent Tekulve | 334 | 383 | -49 |
| 1982-07-20 | vs PIT | 92 | L 1-3 | 34-58 | 6 | 17,395 | Bruce Berenyi | John Candelaria | John Candelaria | Bruce Berenyi | Kent Tekulve | 335 | 386 | -51 |
| 1982-07-21 | vs PIT | 93 | L 2-3 | 34-59 | 6 | 16,543 | Bob Shirley | Larry McWilliams | Larry McWilliams | Tom Hume | Kent Tekulve | 337 | 389 | -52 |
| 1982-07-23 | vs CHN | 94 | L 5-7 | 34-60 | 6 | 17,939 | Mario Soto | Dickie Noles | Guillermo Hernandez | Jim Kern | Lee Smith | 342 | 396 | -54 |
| 1982-07-24 | vs CHN | 95 | W 5-2 | 35-60 | 6 | 28,138 | Frank Pastore | Doug Bird | Frank Pastore | Doug Bird | Joe Price | 347 | 398 | -51 |
| 1982-07-25 | vs CHN | 96 | W 2-1 | 36-60 | 6 | 20,056 | Bruce Berenyi | Fergie Jenkins | Bruce Berenyi | Fergie Jenkins | | 349 | 399 | -50 |
| 1982-07-26 | vs CHN | 97 | W 4-2 | 37-60 | 6 | 13,092 | Bob Shirley | Allen Ripley | Bob Shirley | Allen Ripley | Tom Hume | 353 | 401 | -48 |
| 1982-07-27 | @ HOU | 98 | L 2-3 | 37-61 | 6 | 19,009 | Charlie Leibrandt | Nolan Ryan | Nolan Ryan | Charlie Leibrandt | | 355 | 404 | -49 |
| 1982-07-28 | @ HOU | 99 | L 2-4 | 37-62 | 6 | 16,271 | Mario Soto | Joe Niekro | Joe Niekro | Mario Soto | | 357 | 408 | -51 |
| 1982-07-29 | @ HOU | 100 | L 3-4 | 37-63 | 6 | 17,261 | Frank Pastore | Bob Knepper | Randy Moffitt | Greg Harris | Frank LaCorte | 360 | 412 | -52 |
| 1982-07-30 | vs SDN | 101 | W 4-2 | 38-63 | 6 | 16,021 | Bruce Berenyi | John Montefusco | Bruce Berenyi | John Montefusco | | 364 | 414 | -50 |
| 1982-07-31 | vs SDN | 102 | L 4-5 | 38-65 | 6 | 0 | Tom Seaver | Tim Lollar | Tim Lollar | Tom Seaver | Dave Dravecky | 368 | 419 | -51 |
| 1982-07-31 | vs SDN | 103 | L 2-6 | 38-65 | 6 | 25,602 | Bob Shirley | Eric Show | Eric Show | Bob Shirley | Gary Lucas | 370 | 425 | -55 |
| 1982-08-01 | vs SDN | 104 | L 6-8 | 38-66 | 6 | 15,461 | Charlie Leibrandt | John Curtis | John Curtis | Charlie Leibrandt | Luis DeLeon | 376 | 433 | -57 |
| 1982-08-02 | vs LAN | 105 | W 5-1 | 39-66 | 6 | 16,104 | Mario Soto | Jerry Reuss | Mario Soto | Jerry Reuss | | 381 | 434 | -53 |
| 1982-08-03 | vs LAN | 106 | L 0-4 | 39-67 | 6 | 18,319 | Frank Pastore | Bob Welch | Bob Welch | Frank Pastore | | 381 | 438 | -57 |
| 1982-08-04 | vs LAN | 107 | L 2-8 | 39-68 | 6 | 21,488 | Bruce Berenyi | Ricky Wright | Ricky Wright | Bruce Berenyi | | 383 | 446 | -63 |
| 1982-08-05 | @ SDN | 108 | W 4-2 | 40-68 | 6 | 13,386 | Tom Seaver | Tim Lollar | Tom Seaver | Tim Lollar | Brad Lesley | 387 | 448 | -61 |
| 1982-08-06 | @ SDN | 109 | L 0-2 | 40-69 | 6 | 11,331 | Bob Shirley | Eric Show | Eric Show | Bob Shirley | | 387 | 450 | -63 |
| 1982-08-07 | @ SDN | 110 | L 1-4 | 40-70 | 6 | 20,890 | Mario Soto | Andy Hawkins | Andy Hawkins | Mario Soto | Gary Lucas | 388 | 454 | -66 |
| 1982-08-08 | @ SDN | 111 | L 1-3 | 40-71 | 6 | 12,097 | Frank Pastore | Dave Dravecky | Dave Dravecky | Frank Pastore | Gary Lucas | 389 | 457 | -68 |
| 1982-08-09 | @ LAN | 112 | L 2-3 | 40-72 | 6 | 34,709 | Bruce Berenyi | Ricky Wright | Dave Stewart | Jim Kern | | 391 | 460 | -69 |
| 1982-08-10 | @ LAN | 113 | L 3-11 | 40-73 | 6 | 50,266 | Tom Seaver | Fernando Valenzuela | Fernando Valenzuela | Tom Seaver | | 394 | 471 | -77 |
| 1982-08-11 | @ LAN | 114 | W 2-1 | 41-73 | 6 | 47,774 | Bob Shirley | Burt Hooton | Bob Shirley | Burt Hooton | Brad Lesley | 396 | 472 | -76 |
| 1982-08-13 | vs HOU | 115 | W 3-0 | 42-73 | 6 | 16,053 | Frank Pastore | Joe Niekro | Frank Pastore | Joe Niekro | | 399 | 472 | -73 |
| 1982-08-14 | vs HOU | 116 | L 0-2 | 42-74 | 6 | 18,105 | Bruce Berenyi | Bob Knepper | Bob Knepper | Bruce Berenyi | Randy Moffitt | 399 | 474 | -75 |
| 1982-08-15 | vs HOU | 117 | L 3-7 | 42-75 | 6 | 18,944 | Tom Seaver | Don Sutton | Don Sutton | Tom Seaver | Bert Roberge | 402 | 481 | -79 |
| 1982-08-16 | vs HOU | 118 | W 3-2 | 43-75 | 6 | 11,368 | Bob Shirley | Nolan Ryan | Jim Kern | Dave Smith | | 405 | 483 | -78 |
| 1982-08-17 | vs NYN | 119 | W 9-2 | 44-75 | 6 | 12,031 | Mario Soto | Rick Ownbey | Mario Soto | Rick Ownbey | | 414 | 485 | -71 |
| 1982-08-18 | vs NYN | 120 | W 7-6 | 45-75 | 6 | 12,182 | Frank Pastore | Pat Zachry | Ben Hayes | Mike Scott | | 421 | 491 | -70 |
| 1982-08-19 | vs NYN | 121 | W 3-1 | 46-75 | 6 | 11,279 | Bruce Berenyi | Craig Swan | Jim Kern | Tom Hausman | | 424 | 492 | -68 |
| 1982-08-20 | vs PHI | 122 | L 2-9 | 46-76 | 6 | 17,638 | Greg Harris | Dick Ruthven | Dick Ruthven | Greg Harris | | 426 | 501 | -75 |
| 1982-08-21 | vs PHI | 123 | W 10-3 | 47-76 | 6 | 24,099 | Bob Shirley | Marty Bystrom | Bob Shirley | Marty Bystrom | | 436 | 504 | -68 |
| 1982-08-22 | vs PHI | 124 | L 2-8 | 47-77 | 6 | 21,670 | Mario Soto | Larry Christenson | Larry Christenson | Mario Soto | | 438 | 512 | -74 |
| 1982-08-23 | vs MON | 125 | W 6-2 | 48-77 | 6 | 10,301 | Frank Pastore | Bill Gullickson | Frank Pastore | Bill Gullickson | | 444 | 514 | -70 |
| 1982-08-24 | vs MON | 126 | L 1-5 | 48-78 | 6 | 8,756 | Bruce Berenyi | Scott Sanderson | Scott Sanderson | Bruce Berenyi | | 445 | 519 | -74 |
| 1982-08-25 | vs MON | 127 | W 1-0 | 49-78 | 6 | 11,339 | Bob Shirley | Steve Rogers | Bob Shirley | Steve Rogers | Brad Lesley | 446 | 519 | -73 |
| 1982-08-27 | @ PHI | 128 | W 8-1 | 50-78 | 6 | 34,429 | Mario Soto | Larry Christenson | Mario Soto | Larry Christenson | | 454 | 520 | -66 |
| 1982-08-28 | @ PHI | 129 | L 1-7 | 50-79 | 6 | 38,333 | Frank Pastore | Mike Krukow | Mike Krukow | Frank Pastore | | 455 | 527 | -72 |
| 1982-08-29 | @ PHI | 130 | L 1-3 | 50-80 | 6 | 39,237 | Bruce Berenyi | Steve Carlton | Steve Carlton | Bruce Berenyi | | 456 | 530 | -74 |
| 1982-08-30 | @ MON | 131 | L 1-3 | 50-81 | 6 | 22,505 | Bob Shirley | Steve Rogers | Steve Rogers | Bob Shirley | Jeff Reardon | 457 | 533 | -76 |
| 1982-08-31 | @ MON | 132 | W 2-1 | 51-81 | 6 | 30,148 | Greg Harris | Bill Gullickson | Charlie Leibrandt | Ray Burris | | 459 | 534 | -75 |
| 1982-09-01 | @ MON | 133 | L 1-2 | 51-82 | 6 | 26,399 | Mario Soto | Randy Lerch | Randy Lerch | Mario Soto | Jeff Reardon | 460 | 536 | -76 |
| 1982-09-03 | @ NYN | 134 | W 1-0 | 52-82 | 6 | 8,570 | Frank Pastore | Rick Ownbey | Frank Pastore | Rick Ownbey | Brad Lesley | 461 | 536 | -75 |
| 1982-09-04 | @ NYN | 135 | L 2-3 | 52-83 | 6 | 11,032 | Bruce Berenyi | Craig Swan | Craig Swan | Bruce Berenyi | Charlie Puleo | 463 | 539 | -76 |
| 1982-09-05 | @ NYN | 136 | L 2-10 | 52-84 | 6 | 13,644 | Bob Shirley | Ed Lynch | Ed Lynch | Bob Shirley | Jesse Orosco | 465 | 549 | -84 |
| 1982-09-06 | vs LAN | 137 | L 2-7 | 52-85 | 6 | 12,053 | Mario Soto | Jerry Reuss | Jerry Reuss | Mario Soto | | 467 | 556 | -89 |
| 1982-09-07 | vs LAN | 138 | L 4-8 | 52-86 | 6 | 11,097 | Greg Harris | Ricky Wright | Dave Stewart | Greg Harris | | 471 | 564 | -93 |
| 1982-09-08 | vs SDN | 139 | L 4-9 | 52-87 | 6 | 8,029 | Frank Pastore | Eric Show | Luis DeLeon | Brad Lesley | | 475 | 573 | -98 |
| 1982-09-09 | vs SDN | 140 | L 1-4 | 52-88 | 6 | 7,292 | Bruce Berenyi | Tim Lollar | Tim Lollar | Bruce Berenyi | Luis DeLeon | 476 | 577 | -101 |
| 1982-09-10 | @ ATL | 141 | L 2-8 | 52-89 | 6 | 17,407 | Bob Shirley | Pascual Perez | Pascual Perez | Bob Shirley | | 478 | 585 | -107 |
| 1982-09-11 | @ ATL | 142 | W 4-3 | 53-89 | 6 | 20,966 | Mario Soto | Tommy Boggs | Mario Soto | Tommy Boggs | | 482 | 588 | -106 |
| 1982-09-12 | @ ATL | 143 | L 3-4 | 53-90 | 6 | 16,442 | Greg Harris | Rick Camp | Steve Bedrosian | Greg Harris | | 485 | 592 | -107 |
| 1982-09-13 | @ SFN | 144 | W 5-4 | 54-90 | 6 | 10,178 | Frank Pastore | Jim Barr | Joe Price | Gary Lavelle | Charlie Leibrandt | 490 | 596 | -106 |
| 1982-09-14 | @ SFN | 145 | L 1-2 | 54-91 | 6 | 3,728 | Bruce Berenyi | Atlee Hammaker | Atlee Hammaker | Bruce Berenyi | Al Holland | 491 | 598 | -107 |
| 1982-09-15 | @ SFN | 146 | L 4-5 | 54-92 | 6 | 3,858 | Bob Shirley | Renie Martin | Rich Gale | Joe Price | Gary Lavelle | 495 | 603 | -108 |
| 1982-09-17 | vs ATL | 147 | W 5-2 | 55-92 | 6 | 11,630 | Mario Soto | Rick Camp | Mario Soto | Rick Camp | | 500 | 605 | -105 |
| 1982-09-18 | vs ATL | 148 | L 4-5 | 55-93 | 6 | 14,121 | Frank Pastore | Phil Niekro | Phil Niekro | Frank Pastore | Gene Garber | 504 | 610 | -106 |
| 1982-09-19 | vs ATL | 149 | L 1-6 | 55-94 | 6 | 12,203 | Bruce Berenyi | Rick Mahler | Pascual Perez | Bruce Berenyi | | 505 | 616 | -111 |
| 1982-09-21 | vs SFN | 150 | W 6-5 | 56-94 | 6 | 6,038 | Bob Shirley | Fred Breining | Bob Shirley | Fred Breining | Ben Hayes | 511 | 621 | -110 |
| 1982-09-22 | vs SFN | 151 | L 0-2 | 56-95 | 6 | 6,384 | Mario Soto | Renie Martin | Renie Martin | Mario Soto | Al Holland | 511 | 623 | -112 |
| 1982-09-23 | vs SFN | 152 | L 7-11 | 56-96 | 6 | 6,629 | Frank Pastore | Bill Laskey | Atlee Hammaker | Frank Pastore | | 518 | 634 | -116 |
| 1982-09-24 | vs HOU | 153 | W 2-0 | 57-96 | 6 | 6,666 | Bruce Berenyi | Joe Niekro | Bruce Berenyi | Joe Niekro | | 520 | 634 | -114 |
| 1982-09-25 | vs HOU | 154 | L 1-3 | 57-97 | 6 | 8,004 | Bill Scherrer | Mike LaCoss | Mike LaCoss | Bill Scherrer | Frank LaCorte | 521 | 637 | -116 |
| 1982-09-26 | vs HOU | 155 | L 0-4 | 57-98 | 6 | 25,125 | Bob Shirley | Nolan Ryan | Nolan Ryan | Bob Shirley | | 521 | 641 | -120 |
| 1982-09-27 | @ LAN | 156 | W 6-1 | 58-98 | 6 | 44,774 | Mario Soto | Jerry Reuss | Mario Soto | Jerry Reuss | | 527 | 642 | -115 |
| 1982-09-28 | @ LAN | 157 | W 4-3 | 59-98 | 6 | 43,375 | Frank Pastore | Bob Welch | Ben Hayes | Dave Stewart | Joe Price | 531 | 645 | -114 |
| 1982-09-29 | @ SDN | 158 | L 2-3 | 59-99 | 6 | 4,931 | Bruce Berenyi | Dave Dravecky | Luis DeLeon | Brad Lesley | | 533 | 648 | -115 |
| 1982-09-30 | @ SDN | 159 | W 6-4 | 60-99 | 6 | 6,886 | Bill Scherrer | Andy Hawkins | Charlie Leibrandt | Floyd Chiffer | Ben Hayes | 539 | 652 | -113 |
| 1982-10-01 | @ HOU | 160 | W 4-2 | 61-99 | 6 | 13,272 | Bob Shirley | Nolan Ryan | Bob Shirley | Nolan Ryan | Joe Price | 543 | 654 | -111 |
| 1982-10-02 | @ HOU | 161 | L 2-4 | 61-100 | 6 | 13,811 | Mario Soto | Frank DiPino | Frank DiPino | Mario Soto | Vern Ruhle | 545 | 658 | -113 |
| 1982-10-03 | @ HOU | 162 | L 0-3 | 61-101 | 6 | 14,672 | Frank Pastore | Joe Niekro | Joe Niekro | Frank Pastore | | 545 | 661 | -116 |