| 1982-04-10 | @ BAL | 1 | W 2-0 | 1-1 | 2 | 0 | Dennis Eckersley | Scott McGregor | Dennis Eckersley | Scott McGregor | | 2 | 0 | 2 |
| 1982-04-10 | @ BAL | 2 | L 3-5 | 1-1 | 2 | 21,268 | Bob Ojeda | Dennis Martinez | Dennis Martinez | Bob Ojeda | Sammy Stewart | 5 | 5 | 0 |
| 1982-04-11 | @ BAL | 3 | W 6-0 | 2-1 | 1 | 11,235 | John Tudor | Mike Flanagan | John Tudor | Mike Flanagan | | 11 | 5 | 6 |
| 1982-04-12 | vs CHA | 4 | L 2-3 | 2-2 | 3 | 32,555 | Mike Torrez | Richard Dotson | Richard Dotson | Mike Torrez | Salome Barojas | 13 | 8 | 5 |
| 1982-04-14 | vs CHA | 5 | L 4-5 | 2-3 | 4 | 9,780 | Chuck Rainey | Steve Trout | Steve Trout | Bob Stanley | Salome Barojas | 17 | 13 | 4 |
| 1982-04-15 | vs CHA | 6 | L 4-8 | 2-4 | 7 | 8,743 | Bob Ojeda | Dennis Lamp | Dennis Lamp | Bob Ojeda | Jerry Koosman | 21 | 21 | 0 |
| 1982-04-16 | vs TOR | 7 | L 0-2 | 2-5 | 7 | 7,542 | Dennis Eckersley | Luis Leal | Luis Leal | Dennis Eckersley | Roy Lee Jackson | 21 | 23 | -2 |
| 1982-04-17 | vs TOR | 8 | W 5-4 | 3-5 | 5 | 18,617 | John Tudor | Mark Bomback | John Tudor | Mark Bomback | Mark Clear | 26 | 27 | -1 |
| 1982-04-18 | vs TOR | 9 | W 4-3 | 4-5 | 3 | 18,017 | Mike Torrez | Jim Clancy | Luis Aponte | Roy Lee Jackson | | 30 | 30 | 0 |
| 1982-04-19 | vs TOR | 10 | L 4-5 | 4-6 | 4 | 27,265 | Chuck Rainey | Dave Stieb | Dale Murray | Mark Clear | | 34 | 35 | -1 |
| 1982-04-20 | vs BAL | 11 | W 8-3 | 5-6 | 3 | 15,253 | Bob Ojeda | Mike Flanagan | Bob Ojeda | Mike Flanagan | Luis Aponte | 42 | 38 | 4 |
| 1982-04-21 | vs BAL | 12 | W 6-5 | 6-6 | 2 | 15,725 | Dennis Eckersley | Dennis Martinez | Dennis Eckersley | Dennis Martinez | Mark Clear | 48 | 43 | 5 |
| 1982-04-23 | @ TOR | 13 | W 5-4 | 7-6 | 2 | 10,428 | John Tudor | Jim Clancy | John Tudor | Jim Clancy | Mark Clear | 53 | 47 | 6 |
| 1982-04-24 | @ TOR | 14 | W 8-7 | 8-6 | 2 | 13,135 | Mike Torrez | Dave Stieb | Mike Torrez | Dave Stieb | Luis Aponte | 61 | 54 | 7 |
| 1982-04-25 | @ TOR | 15 | W 5-4 | 9-6 | 2 | 21,043 | Bob Ojeda | Luis Leal | Mark Clear | Joey McLaughlin | | 66 | 58 | 8 |
| 1982-04-26 | @ CHA | 16 | W 3-2 | 11-6 | 1 | 0 | Bruce Hurst | Richard Dotson | Luis Aponte | Richard Dotson | | 69 | 60 | 9 |
| 1982-04-26 | @ CHA | 17 | W 5-0 | 11-6 | 1 | 5,798 | Chuck Rainey | Chico Escarrega | Chuck Rainey | Chico Escarrega | | 74 | 60 | 14 |
| 1982-04-27 | vs KCA | 18 | W 7-5 | 12-6 | 1 | 12,998 | Dennis Eckersley | Dave Frost | Bob Stanley | Dave Frost | | 81 | 65 | 16 |
| 1982-04-28 | vs KCA | 19 | L 5-8 | 12-7 | 1 | 12,368 | John Tudor | Dennis Leonard | Dennis Leonard | John Tudor | | 86 | 73 | 13 |
| 1982-04-30 | vs TEX | 20 | W 7-1 | 13-7 | 1 | 19,370 | Mike Torrez | Charlie Hough | Mike Torrez | Charlie Hough | | 93 | 74 | 19 |
| 1982-05-01 | vs TEX | 21 | W 6-5 | 14-7 | 1 | 32,764 | Bob Ojeda | Rick Honeycutt | Mark Clear | Steve Comer | | 99 | 79 | 20 |
| 1982-05-02 | vs TEX | 22 | W 6-0 | 15-7 | 1 | 21,011 | Dennis Eckersley | Doc Medich | Dennis Eckersley | Doc Medich | | 105 | 79 | 26 |
| 1982-05-03 | vs MIN | 23 | W 6-2 | 16-7 | 1 | 12,065 | Chuck Rainey | Terry Felton | Chuck Rainey | Terry Felton | Bob Stanley | 111 | 81 | 30 |
| 1982-05-04 | vs MIN | 24 | W 5-3 | 17-7 | 1 | 13,726 | Bruce Hurst | Pete Redfern | Bruce Hurst | Pete Redfern | Luis Aponte | 116 | 84 | 32 |
| 1982-05-05 | vs MIN | 25 | L 2-3 | 17-8 | 1 | 14,685 | Mike Torrez | Roger Erickson | Roger Erickson | Mike Torrez | Doug Corbett | 118 | 87 | 31 |
| 1982-05-06 | @ TEX | 26 | W 5-2 | 18-8 | 1 | 8,737 | Bob Ojeda | Rick Honeycutt | Bob Stanley | Rick Honeycutt | | 123 | 89 | 34 |
| 1982-05-07 | @ TEX | 27 | L 0-1 | 18-9 | 1 | 14,338 | Dennis Eckersley | Doc Medich | Doc Medich | Dennis Eckersley | Danny Darwin | 123 | 90 | 33 |
| 1982-05-08 | @ TEX | 28 | W 2-1 | 19-9 | 1 | 18,950 | Chuck Rainey | Jon Matlack | Chuck Rainey | Jon Matlack | Mark Clear | 125 | 91 | 34 |
| 1982-05-09 | @ TEX | 29 | W 1-0 | 20-9 | 1 | 12,789 | John Tudor | Frank Tanana | Bob Stanley | Frank Tanana | Mark Clear | 126 | 91 | 35 |
| 1982-05-10 | @ MIN | 30 | W 9-5 | 21-9 | 1 | 7,790 | Mike Torrez | Roger Erickson | Tom Burgmeier | Roger Erickson | | 135 | 96 | 39 |
| 1982-05-11 | @ MIN | 31 | L 6-10 | 21-10 | 1 | 8,321 | Bob Ojeda | Brad Havens | Bobby Castillo | Bob Ojeda | | 141 | 106 | 35 |
| 1982-05-12 | @ MIN | 32 | W 4-1 | 22-10 | 1 | 11,264 | Dennis Eckersley | Albert Williams | Dennis Eckersley | Ron Davis | Mark Clear | 145 | 107 | 38 |
| 1982-05-13 | @ KCA | 33 | L 2-11 | 22-11 | 1 | 17,459 | Chuck Rainey | Dave Frost | Dave Frost | Chuck Rainey | | 147 | 118 | 29 |
| 1982-05-15 | @ KCA | 34 | W 10-5 | 23-11 | 1 | 37,506 | Mike Torrez | Vida Blue | Mike Torrez | Vida Blue | Mark Clear | 157 | 123 | 34 |
| 1982-05-16 | @ KCA | 35 | L 0-5 | 23-12 | 1 | 34,395 | Bob Ojeda | Dennis Leonard | Dennis Leonard | Bob Ojeda | | 157 | 128 | 29 |
| 1982-05-18 | vs SEA | 36 | L 0-3 | 23-13 | 2 | 16,436 | Dennis Eckersley | Floyd Bannister | Floyd Bannister | Dennis Eckersley | | 157 | 131 | 26 |
| 1982-05-19 | vs SEA | 37 | W 6-5 | 24-13 | 2 | 12,927 | Chuck Rainey | Larry Andersen | Mark Clear | Bill Caudill | | 163 | 136 | 27 |
| 1982-05-20 | vs SEA | 38 | W 11-2 | 25-13 | 2 | 14,587 | John Tudor | Mike Moore | John Tudor | Mike Moore | | 174 | 138 | 36 |
| 1982-05-21 | vs OAK | 39 | W 8-7 | 26-13 | 1 | 29,671 | Mike Torrez | Rick Langford | Tom Burgmeier | Rick Langford | Mark Clear | 182 | 145 | 37 |
| 1982-05-22 | vs OAK | 40 | W 7-4 | 27-13 | 1 | 36,654 | Bob Ojeda | Bo McLaughlin | Bob Stanley | Bo McLaughlin | | 189 | 149 | 40 |
| 1982-05-23 | vs OAK | 41 | W 6-0 | 28-13 | 1 | 24,421 | Dennis Eckersley | Mike Norris | Dennis Eckersley | Mike Norris | | 195 | 149 | 46 |
| 1982-05-25 | vs CAL | 42 | L 2-10 | 28-14 | 1 | 28,238 | John Tudor | Bruce Kison | Bruce Kison | John Tudor | | 197 | 159 | 38 |
| 1982-05-27 | @ SEA | 43 | L 6-10 | 28-15 | 1 | 6,186 | Mike Torrez | Gene Nelson | Gene Nelson | Mike Torrez | | 203 | 169 | 34 |
| 1982-05-28 | @ SEA | 44 | W 3-2 | 29-15 | 1 | 10,634 | Dennis Eckersley | Floyd Bannister | Dennis Eckersley | Floyd Bannister | Mark Clear | 206 | 171 | 35 |
| 1982-05-29 | @ SEA | 45 | L 2-4 | 29-16 | 1 | 25,756 | Bruce Hurst | Mike Moore | Mike Moore | Bruce Hurst | Bill Caudill | 208 | 175 | 33 |
| 1982-05-30 | @ SEA | 46 | L 1-2 | 29-17 | 1 | 9,857 | John Tudor | Jim Beattie | Jim Beattie | John Tudor | | 209 | 177 | 32 |
| 1982-05-31 | @ OAK | 47 | W 5-2 | 30-17 | 1 | 37,143 | Bob Ojeda | Bo McLaughlin | Bob Ojeda | Bo McLaughlin | Bob Stanley | 214 | 179 | 35 |
| 1982-06-01 | @ OAK | 48 | L 2-3 | 30-18 | 2 | 13,052 | Chuck Rainey | Rick Langford | Rick Langford | Chuck Rainey | Tom Underwood | 216 | 182 | 34 |
| 1982-06-02 | @ OAK | 49 | L 0-5 | 30-19 | 2 | 15,205 | Dennis Eckersley | Mike Norris | Mike Norris | Dennis Eckersley | | 216 | 187 | 29 |
| 1982-06-04 | @ CAL | 50 | W 11-4 | 31-19 | 2 | 33,160 | Bruce Hurst | Steve Renko | Mark Clear | Doug Corbett | | 227 | 191 | 36 |
| 1982-06-05 | @ CAL | 51 | W 7-2 | 32-19 | 2 | 37,885 | John Tudor | Bruce Kison | John Tudor | Bruce Kison | | 234 | 193 | 41 |
| 1982-06-06 | @ CAL | 52 | W 5-1 | 33-19 | 2 | 34,941 | Bob Ojeda | Ken Forsch | Bob Ojeda | Ken Forsch | Mark Clear | 239 | 194 | 45 |
| 1982-06-08 | vs NYA | 53 | W 4-3 | 34-19 | 2 | 31,413 | Dennis Eckersley | Ron Guidry | Mark Clear | George Frazier | | 243 | 197 | 46 |
| 1982-06-09 | vs NYA | 54 | W 3-2 | 35-19 | 2 | 32,792 | Bruce Hurst | Tommy John | Bruce Hurst | Tommy John | Bob Stanley | 246 | 199 | 47 |
| 1982-06-10 | vs NYA | 55 | L 3-5 | 35-20 | 2 | 33,462 | John Tudor | Dave Righetti | Dave Righetti | John Tudor | Rich Gossage | 249 | 204 | 45 |
| 1982-06-11 | vs CLE | 56 | W 6-2 | 36-20 | 2 | 30,846 | Bob Ojeda | Lary Sorensen | Tom Burgmeier | Lary Sorensen | | 255 | 206 | 49 |
| 1982-06-12 | vs CLE | 57 | W 6-4 | 37-20 | 2 | 30,531 | Mike Torrez | John Denny | Bob Stanley | John Denny | | 261 | 210 | 51 |
| 1982-06-14 | @ NYA | 58 | L 1-5 | 37-21 | 1 | 35,159 | Dennis Eckersley | Ron Guidry | Ron Guidry | Dennis Eckersley | | 262 | 215 | 47 |
| 1982-06-15 | @ NYA | 59 | L 4-5 | 37-22 | 1 | 35,559 | Bruce Hurst | Tommy John | Rich Gossage | Mark Clear | | 266 | 220 | 46 |
| 1982-06-16 | @ NYA | 60 | L 1-4 | 37-23 | 2 | 30,267 | John Tudor | Dave Righetti | Dave Righetti | John Tudor | | 267 | 224 | 43 |
| 1982-06-17 | @ CLE | 61 | W 6-3 | 38-23 | 1 | 12,824 | Mike Torrez | Lary Sorensen | Mike Torrez | Lary Sorensen | Mark Clear | 273 | 227 | 46 |
| 1982-06-18 | @ CLE | 62 | L 3-10 | 38-24 | 1 | 16,618 | Dennis Eckersley | John Denny | John Denny | Dennis Eckersley | | 276 | 237 | 39 |
| 1982-06-19 | @ CLE | 63 | W 7-3 | 39-24 | 1 | 18,744 | Chuck Rainey | Rick Sutcliffe | Chuck Rainey | Rick Sutcliffe | Bob Stanley | 283 | 240 | 43 |
| 1982-06-20 | @ CLE | 64 | L 4-5 | 39-25 | 1 | 26,571 | Bruce Hurst | Len Barker | Dan Spillner | Luis Aponte | | 287 | 245 | 42 |
| 1982-06-21 | vs DET | 65 | W 5-1 | 40-25 | 1 | 24,234 | John Tudor | Dan Petry | John Tudor | Dan Petry | Bob Stanley | 292 | 246 | 46 |
| 1982-06-22 | vs DET | 66 | W 5-4 | 41-25 | 1 | 28,215 | Mike Torrez | Milt Wilcox | Mark Clear | Dave Tobik | | 297 | 250 | 47 |
| 1982-06-23 | vs DET | 67 | W 10-4 | 42-25 | 1 | 30,547 | Dennis Eckersley | Jack Morris | Dennis Eckersley | Jack Morris | | 307 | 254 | 53 |
| 1982-06-25 | vs MIL | 68 | L 3-9 | 42-26 | 1 | 32,656 | Bruce Hurst | Randy Lerch | Jim Slaton | Bruce Hurst | | 310 | 263 | 47 |
| 1982-06-26 | vs MIL | 69 | L 10-11 | 42-27 | 1 | 33,393 | John Tudor | Moose Haas | Rollie Fingers | Mark Clear | | 320 | 274 | 46 |
| 1982-06-27 | vs MIL | 70 | L 5-7 | 42-28 | 1 | 32,744 | Mike Torrez | Bob McClure | Bob McClure | Mike Torrez | Dwight Bernard | 325 | 281 | 44 |
| 1982-06-28 | vs MIL | 71 | W 9-7 | 43-28 | 1 | 25,773 | Chuck Rainey | Pete Vuckovich | Bob Stanley | Pete Vuckovich | | 334 | 288 | 46 |
| 1982-06-29 | @ DET | 72 | W 4-2 | 44-28 | 1 | 32,697 | Dennis Eckersley | Jerry Ujdur | Dennis Eckersley | Jerry Ujdur | | 338 | 290 | 48 |
| 1982-06-30 | @ DET | 73 | L 3-12 | 44-29 | 1 | 24,691 | Bruce Hurst | Dan Petry | Dan Petry | Bruce Hurst | | 341 | 302 | 39 |
| 1982-07-01 | @ DET | 74 | L 4-5 | 44-30 | 1 | 27,243 | John Tudor | Milt Wilcox | Milt Wilcox | Bob Stanley | | 345 | 307 | 38 |
| 1982-07-02 | @ MIL | 75 | L 5-14 | 44-31 | 1 | 28,957 | Mike Torrez | Bob McClure | Bob McClure | Mike Torrez | | 350 | 321 | 29 |
| 1982-07-03 | @ MIL | 76 | L 0-7 | 44-32 | 1 | 55,716 | Chuck Rainey | Pete Vuckovich | Pete Vuckovich | Chuck Rainey | | 350 | 328 | 22 |
| 1982-07-04 | @ MIL | 77 | W 4-1 | 45-32 | 1 | 35,947 | Dennis Eckersley | Mike Caldwell | Dennis Eckersley | Mike Caldwell | | 354 | 329 | 25 |
| 1982-07-05 | @ KCA | 78 | W 4-3 | 46-33 | 1 | 0 | Bruce Hurst | Paul Splittorff | Bob Stanley | Mike Armstrong | | 358 | 332 | 26 |
| 1982-07-05 | @ KCA | 79 | L 3-4 | 46-33 | 1 | 41,024 | Bob Ojeda | Don Hood | Don Hood | Bob Ojeda | Dan Quisenberry | 361 | 336 | 25 |
| 1982-07-06 | @ KCA | 80 | L 2-6 | 46-34 | 1 | 22,380 | John Tudor | Vida Blue | Vida Blue | John Tudor | Bill Castro | 363 | 342 | 21 |
| 1982-07-07 | @ TEX | 81 | W 8-5 | 47-34 | 1 | 12,653 | Mike Torrez | Charlie Hough | Mike Torrez | Charlie Hough | | 371 | 347 | 24 |
| 1982-07-08 | @ TEX | 82 | W 3-0 | 48-34 | 1 | 14,066 | Chuck Rainey | Rick Honeycutt | Chuck Rainey | Rick Honeycutt | | 374 | 347 | 27 |
| 1982-07-09 | vs MIN | 83 | L 1-4 | 48-35 | 1 | 27,270 | Dennis Eckersley | Frank Viola | Frank Viola | Dennis Eckersley | | 375 | 351 | 24 |
| 1982-07-10 | vs MIN | 84 | W 5-4 | 49-35 | 1 | 26,022 | Bruce Hurst | Bobby Castillo | Bruce Hurst | Bobby Castillo | Bob Stanley | 380 | 355 | 25 |
| 1982-07-11 | vs MIN | 85 | L 3-7 | 49-36 | 1 | 26,910 | John Tudor | Brad Havens | Brad Havens | Mark Clear | Ron Davis | 383 | 362 | 21 |
| 1982-07-15 | vs KCA | 86 | W 5-3 | 50-36 | 1 | 29,186 | Mike Torrez | Larry Gura | Tom Burgmeier | Larry Gura | | 388 | 365 | 23 |
| 1982-07-16 | vs KCA | 87 | W 7-3 | 51-36 | 1 | 30,811 | Dennis Eckersley | Vida Blue | Dennis Eckersley | Vida Blue | Bob Stanley | 395 | 368 | 27 |
| 1982-07-17 | vs KCA | 88 | W 8-4 | 52-36 | 1 | 30,962 | Bruce Hurst | Paul Splittorff | Mark Clear | Dan Quisenberry | Tom Burgmeier | 403 | 372 | 31 |
| 1982-07-18 | vs KCA | 89 | L 0-9 | 52-37 | 2 | 28,072 | John Tudor | Derek Botelho | Derek Botelho | John Tudor | | 403 | 381 | 22 |
| 1982-07-19 | vs TEX | 90 | W 9-5 | 53-37 | 1 | 19,218 | Chuck Rainey | Doc Medich | Mark Clear | Danny Darwin | | 412 | 386 | 26 |
| 1982-07-21 | vs TEX | 91 | L 3-6 | 54-38 | 1 | 0 | Dennis Eckersley | Charlie Hough | Charlie Hough | Dennis Eckersley | Dave J. Schmidt | 415 | 392 | 23 |
| 1982-07-21 | vs TEX | 92 | W 6-1 | 54-38 | 1 | 30,225 | Mike Torrez | Rick Honeycutt | Mike Torrez | Rick Honeycutt | | 421 | 393 | 28 |
| 1982-07-23 | @ MIN | 93 | L 4-8 | 54-39 | 1 | 11,452 | Bruce Hurst | Bobby Castillo | Bobby Castillo | Bruce Hurst | Ron Davis | 425 | 401 | 24 |
| 1982-07-24 | @ MIN | 94 | L 3-5 | 54-40 | 2 | 15,194 | Chuck Rainey | Brad Havens | Brad Havens | Bob Stanley | Ron Davis | 428 | 406 | 22 |
| 1982-07-25 | @ MIN | 95 | W 5-0 | 55-40 | 1 | 10,961 | Mike Torrez | Albert Williams | Mike Torrez | Albert Williams | | 433 | 406 | 27 |
| 1982-07-26 | vs TOR | 96 | W 3-2 | 56-40 | 1 | 22,261 | Dennis Eckersley | Jim Gott | Dennis Eckersley | Jim Gott | | 436 | 408 | 28 |
| 1982-07-27 | vs TOR | 97 | L 1-3 | 56-41 | 1 | 27,077 | John Tudor | Luis Leal | Luis Leal | John Tudor | | 437 | 411 | 26 |
| 1982-07-28 | vs TOR | 98 | W 9-7 | 57-41 | 1 | 18,627 | Bruce Hurst | Dave Stieb | Bob Ojeda | Roy Lee Jackson | Bob Stanley | 446 | 418 | 28 |
| 1982-07-29 | @ CHA | 99 | W 7-3 | 58-41 | 1 | 21,137 | Chuck Rainey | Dennis Lamp | Chuck Rainey | Dennis Lamp | Mark Clear | 453 | 421 | 32 |
| 1982-07-30 | @ CHA | 100 | L 6-9 | 58-42 | 1 | 30,063 | Mike Torrez | LaMarr Hoyt | LaMarr Hoyt | Mike Torrez | Salome Barojas | 459 | 430 | 29 |
| 1982-07-31 | @ CHA | 101 | L 5-7 | 58-43 | 1 | 31,886 | Dennis Eckersley | Britt Burns | Britt Burns | Dennis Eckersley | Salome Barojas | 464 | 437 | 27 |
| 1982-08-01 | @ CHA | 102 | L 2-4 | 58-44 | 2 | 26,047 | Bruce Hurst | Jerry Koosman | Jerry Koosman | Bruce Hurst | Dennis Lamp | 466 | 441 | 25 |
| 1982-08-02 | @ BAL | 103 | W 5-2 | 59-44 | 1 | 25,010 | John Tudor | Scott McGregor | John Tudor | Scott McGregor | Bob Stanley | 471 | 443 | 28 |
| 1982-08-03 | @ BAL | 104 | L 2-7 | 60-45 | 1 | 0 | Chuck Rainey | Dennis Martinez | Dennis Martinez | Chuck Rainey | | 473 | 450 | 23 |
| 1982-08-03 | @ BAL | 105 | W 7-6 | 60-45 | 1 | 41,076 | Mike Torrez | Sammy Stewart | Mark Clear | Ross Grimsley | | 480 | 456 | 24 |
| 1982-08-04 | @ BAL | 106 | L 2-4 | 60-46 | 2 | 25,625 | Dennis Eckersley | Mike Flanagan | Mike Flanagan | Bob Stanley | Tim Stoddard | 482 | 460 | 22 |
| 1982-08-06 | vs CHA | 107 | L 3-6 | 60-47 | 2 | 33,010 | Bruce Hurst | Jerry Koosman | Jerry Koosman | Bruce Hurst | Dennis Lamp | 485 | 466 | 19 |
| 1982-08-07 | vs CHA | 108 | L 3-7 | 60-48 | 2 | 33,595 | John Tudor | Richard Dotson | Richard Dotson | John Tudor | Kevin Hickey | 488 | 473 | 15 |
| 1982-08-08 | vs CHA | 109 | W 12-6 | 61-48 | 2 | 27,312 | Chuck Rainey | Steve Trout | Tom Burgmeier | Steve Trout | | 500 | 479 | 21 |
| 1982-08-09 | @ TOR | 110 | L 2-4 | 61-49 | 2 | 20,105 | Dennis Eckersley | Luis Leal | Ken Schrom | Dennis Eckersley | Joey McLaughlin | 502 | 483 | 19 |
| 1982-08-10 | @ TOR | 111 | L 0-4 | 61-50 | 2 | 21,324 | Mike Torrez | Dave Stieb | Dave Stieb | Mike Torrez | | 502 | 487 | 15 |
| 1982-08-11 | @ TOR | 112 | L 3-4 | 61-51 | 2 | 22,012 | Bruce Hurst | Jim Clancy | Roy Lee Jackson | Bob Stanley | | 505 | 491 | 14 |
| 1982-08-13 | vs BAL | 113 | W 5-2 | 62-51 | 2 | 32,935 | John Tudor | Mike Flanagan | John Tudor | Mike Flanagan | | 510 | 493 | 17 |
| 1982-08-14 | vs BAL | 114 | L 2-5 | 62-52 | 2 | 31,343 | Dennis Eckersley | Jim Palmer | Tippy Martinez | Mark Clear | | 512 | 498 | 14 |
| 1982-08-15 | vs BAL | 115 | W 8-0 | 63-52 | 2 | 30,675 | Mike Torrez | Scott McGregor | Bob Stanley | Scott McGregor | | 520 | 498 | 22 |
| 1982-08-16 | vs BAL | 116 | W 9-4 | 64-52 | 2 | 34,746 | Chuck Rainey | Dennis Martinez | Tom Burgmeier | Storm Davis | | 529 | 502 | 27 |
| 1982-08-17 | @ CAL | 117 | L 2-10 | 64-53 | 2 | 38,051 | Bob Ojeda | Luis Tiant | Luis Tiant | Bob Ojeda | | 531 | 512 | 19 |
| 1982-08-18 | @ CAL | 118 | W 4-1 | 65-53 | 2 | 38,432 | John Tudor | Mike Witt | John Tudor | Mike Witt | Bob Stanley | 535 | 513 | 22 |
| 1982-08-19 | @ CAL | 119 | L 5-8 | 65-54 | 2 | 38,693 | Dennis Eckersley | Steve Renko | Bruce Kison | Mark Clear | | 540 | 521 | 19 |
| 1982-08-20 | @ OAK | 120 | L 3-4 | 65-55 | 2 | 20,000 | Mike Torrez | Brian Kingman | Dave Beard | Mark Clear | | 543 | 525 | 18 |
| 1982-08-21 | @ OAK | 121 | L 5-12 | 65-56 | 2 | 36,162 | Chuck Rainey | Steve McCatty | Bob Owchinko | Bob Stanley | | 548 | 537 | 11 |
| 1982-08-22 | @ OAK | 122 | W 4-2 | 66-56 | 2 | 31,398 | Brian Denman | Rick Langford | Brian Denman | Rick Langford | Tom Burgmeier | 552 | 539 | 13 |
| 1982-08-23 | @ SEA | 123 | W 4-3 | 67-56 | 2 | 11,748 | John Tudor | Gaylord Perry | Mark Clear | Bill Caudill | | 556 | 542 | 14 |
| 1982-08-24 | @ SEA | 124 | W 5-4 | 68-56 | 2 | 27,087 | Bruce Hurst | Bob Stoddard | Tom Burgmeier | Bill Caudill | | 561 | 546 | 15 |
| 1982-08-26 | vs CAL | 125 | L 1-10 | 69-57 | 2 | 19,902 | Mike Torrez | Ken Forsch | Ken Forsch | Mike Torrez | | 562 | 556 | 6 |
| 1982-08-26 | vs CAL | 126 | W 4-3 | 69-57 | 2 | 31,406 | Chuck Rainey | Geoff Zahn | Bob Stanley | Geoff Zahn | | 566 | 559 | 7 |
| 1982-08-27 | vs CAL | 127 | L 6-7 | 69-58 | 3 | 32,755 | Brian Denman | Rick Steirer | Rick Steirer | Brian Denman | Doug Corbett | 572 | 566 | 6 |
| 1982-08-28 | vs CAL | 128 | W 7-6 | 70-58 | 3 | 34,772 | John Tudor | Mike Witt | Mark Clear | Bruce Kison | | 579 | 572 | 7 |
| 1982-08-29 | vs CAL | 129 | W 9-3 | 71-58 | 3 | 32,356 | Dennis Eckersley | Steve Renko | Dennis Eckersley | Steve Renko | Bob Stanley | 588 | 575 | 13 |
| 1982-08-30 | vs OAK | 130 | W 9-7 | 72-58 | 3 | 24,128 | Mike Torrez | Matt Keough | Mark Clear | Tom Underwood | | 597 | 582 | 15 |
| 1982-08-31 | vs OAK | 131 | W 4-0 | 73-58 | 3 | 23,550 | Chuck Rainey | Preston Hanna | Chuck Rainey | Preston Hanna | | 601 | 582 | 19 |
| 1982-09-01 | vs OAK | 132 | W 7-4 | 74-58 | 3 | 18,489 | Brian Denman | Steve McCatty | Brian Denman | Bob Owchinko | Mark Clear | 608 | 586 | 22 |
| 1982-09-03 | vs SEA | 133 | W 10-8 | 75-58 | 3 | 22,586 | John Tudor | Floyd Bannister | John Tudor | Floyd Bannister | Bob Stanley | 618 | 594 | 24 |
| 1982-09-04 | vs SEA | 134 | L 3-4 | 75-59 | 3 | 21,744 | Dennis Eckersley | Gaylord Perry | Gaylord Perry | Bruce Hurst | Bill Caudill | 621 | 598 | 23 |
| 1982-09-05 | vs SEA | 135 | W 6-5 | 76-59 | 3 | 22,717 | Chuck Rainey | Bob Stoddard | Mark Clear | Bill Caudill | | 627 | 603 | 24 |
| 1982-09-06 | @ CLE | 136 | W 10-3 | 77-59 | 3 | 37,699 | Mike Torrez | Lary Sorensen | Mike Torrez | Lary Sorensen | Bob Stanley | 637 | 606 | 31 |
| 1982-09-07 | @ CLE | 137 | L 4-5 | 77-60 | 3 | 4,219 | Brian Denman | Rick Sutcliffe | Dan Spillner | Mark Clear | | 641 | 611 | 30 |
| 1982-09-08 | @ CLE | 138 | L 0-2 | 77-61 | 3 | 4,907 | John Tudor | Ed Whitson | Ed Whitson | John Tudor | | 641 | 613 | 28 |
| 1982-09-10 | vs DET | 139 | L 4-6 | 77-62 | 3 | 27,199 | Dennis Eckersley | Jack Morris | Jack Morris | Dennis Eckersley | Aurelio Lopez | 645 | 619 | 26 |
| 1982-09-11 | vs DET | 140 | W 13-3 | 78-62 | 3 | 25,451 | Mike Torrez | Milt Wilcox | Mike Torrez | Milt Wilcox | | 658 | 622 | 36 |
| 1982-09-12 | vs DET | 141 | W 10-7 | 79-62 | 3 | 25,154 | Brian Denman | Dave Tobik | Bob Stanley | Dave Tobik | | 668 | 629 | 39 |
| 1982-09-13 | vs CLE | 142 | L 1-3 | 79-64 | 3 | 0 | Oil Can Boyd | Ed Whitson | Ed Whitson | Oil Can Boyd | Dan Spillner | 669 | 632 | 37 |
| 1982-09-13 | vs CLE | 143 | L 3-4 | 79-64 | 3 | 19,717 | Chuck Rainey | Bud Anderson | Tom Brennan | Luis Aponte | | 672 | 636 | 36 |
| 1982-09-14 | vs CLE | 144 | W 12-1 | 80-64 | 3 | 15,765 | John Tudor | Neal Heaton | John Tudor | Neal Heaton | | 684 | 637 | 47 |
| 1982-09-15 | vs CLE | 145 | L 4-7 | 80-65 | 3 | 15,264 | Dennis Eckersley | Len Barker | Len Barker | Dennis Eckersley | Dan Spillner | 688 | 644 | 44 |
| 1982-09-16 | @ DET | 146 | L 2-4 | 80-66 | 3 | 8,253 | Mike Torrez | Milt Wilcox | Milt Wilcox | Mike Torrez | | 690 | 648 | 42 |
| 1982-09-17 | @ DET | 147 | L 1-5 | 80-67 | 3 | 17,451 | Brian Denman | Dan Petry | Dan Petry | Brian Denman | Aurelio Lopez | 691 | 653 | 38 |
| 1982-09-18 | @ DET | 148 | W 6-2 | 81-67 | 3 | 18,425 | Chuck Rainey | Jerry Ujdur | Bob Stanley | Jerry Ujdur | | 697 | 655 | 42 |
| 1982-09-19 | @ DET | 149 | W 6-4 | 82-67 | 3 | 16,209 | John Tudor | Dave Rucker | John Tudor | Dave Rucker | Mark Clear | 703 | 659 | 44 |
| 1982-09-20 | @ MIL | 150 | L 3-4 | 82-68 | 3 | 13,641 | Dennis Eckersley | Pete Vuckovich | Pete Vuckovich | Bob Stanley | | 706 | 663 | 43 |
| 1982-09-21 | @ MIL | 151 | W 4-3 | 83-68 | 3 | 19,864 | Mike Torrez | Doc Medich | Mark Clear | Doc Medich | | 710 | 666 | 44 |
| 1982-09-22 | @ MIL | 152 | L 1-3 | 83-69 | 3 | 24,150 | Brian Denman | Mike Caldwell | Mike Caldwell | Brian Denman | | 711 | 669 | 42 |
| 1982-09-24 | vs NYA | 153 | W 4-2 | 84-69 | 3 | 32,077 | John Tudor | Jay Howell | John Tudor | Jay Howell | | 715 | 671 | 44 |
| 1982-09-25 | vs NYA | 154 | L 2-6 | 84-70 | 3 | 33,559 | Dennis Eckersley | Shane Rawley | Shane Rawley | Dennis Eckersley | | 717 | 677 | 40 |
| 1982-09-26 | vs NYA | 155 | W 5-2 | 85-70 | 3 | 32,793 | Mike Torrez | Ron Guidry | Bob Stanley | Ron Guidry | | 722 | 679 | 43 |
| 1982-09-27 | vs NYA | 156 | L 3-10 | 85-71 | 3 | 21,359 | Brian Denman | Dave Righetti | Dave Righetti | Brian Denman | | 725 | 689 | 36 |
| 1982-09-28 | vs MIL | 157 | L 3-9 | 85-72 | 3 | 19,356 | Chuck Rainey | Doc Medich | Doc Medich | Chuck Rainey | Moose Haas | 728 | 698 | 30 |
| 1982-09-29 | vs MIL | 158 | L 3-6 | 85-73 | 3 | 18,390 | John Tudor | Don Sutton | Bob McClure | Mark Clear | | 731 | 704 | 27 |
| 1982-09-30 | vs MIL | 159 | W 9-4 | 86-73 | 3 | 21,268 | Dennis Eckersley | Jim Slaton | Dennis Eckersley | Jim Slaton | Bob Stanley | 740 | 708 | 32 |
| 1982-10-01 | @ NYA | 160 | W 3-2 | 87-73 | 3 | 26,142 | Mike Torrez | Ron Guidry | Steve Crawford | Mike Morgan | | 743 | 710 | 33 |
| 1982-10-02 | @ NYA | 161 | W 5-0 | 88-73 | 3 | 36,917 | Brian Denman | Dave Righetti | Brian Denman | Dave Righetti | | 748 | 710 | 38 |
| 1982-10-03 | @ NYA | 162 | W 5-3 | 89-73 | 3 | 31,465 | Bruce Hurst | Doyle Alexander | Mike Brown | Rudy May | | 753 | 713 | 40 |