| 1982-04-05 | vs KCA | 1 | W 13-5 | 1-0 | 1 | 51,958 | Dennis Martinez | Dennis Leonard | Sammy Stewart | Dennis Leonard | | 13 | 5 | 8 |
| 1982-04-10 | vs BOS | 2 | L 0-2 | 2-1 | 1 | 0 | Scott McGregor | Dennis Eckersley | Dennis Eckersley | Scott McGregor | | 13 | 7 | 6 |
| 1982-04-10 | vs BOS | 3 | W 5-3 | 2-1 | 1 | 21,268 | Dennis Martinez | Bob Ojeda | Dennis Martinez | Bob Ojeda | Sammy Stewart | 18 | 10 | 8 |
| 1982-04-11 | vs BOS | 4 | L 0-6 | 2-2 | 3 | 11,235 | Mike Flanagan | John Tudor | John Tudor | Mike Flanagan | | 18 | 16 | 2 |
| 1982-04-13 | @ KCA | 5 | L 5-6 | 2-3 | 4 | 14,662 | Jim Palmer | Larry Gura | Dave Frost | Sammy Stewart | Dan Quisenberry | 23 | 22 | 1 |
| 1982-04-14 | @ KCA | 6 | L 3-4 | 2-4 | 6 | 20,382 | Scott McGregor | Dennis Leonard | Dave Frost | Don Stanhouse | | 26 | 26 | 0 |
| 1982-04-17 | @ CHA | 7 | L 1-3 | 2-6 | 7 | 0 | Dennis Martinez | Britt Burns | Britt Burns | Dennis Martinez | Salome Barojas | 27 | 29 | -2 |
| 1982-04-17 | @ CHA | 8 | L 6-10 | 2-6 | 7 | 28,977 | Jim Palmer | Richard Dotson | LaMarr Hoyt | Tippy Martinez | | 33 | 39 | -6 |
| 1982-04-18 | @ CHA | 9 | L 4-6 | 2-7 | 7 | 34,322 | Scott McGregor | Jerry Koosman | LaMarr Hoyt | Scott McGregor | Salome Barojas | 37 | 45 | -8 |
| 1982-04-20 | @ BOS | 10 | L 3-8 | 2-8 | 7 | 15,253 | Mike Flanagan | Bob Ojeda | Bob Ojeda | Mike Flanagan | Luis Aponte | 40 | 53 | -13 |
| 1982-04-21 | @ BOS | 11 | L 5-6 | 2-9 | 7 | 15,725 | Dennis Martinez | Dennis Eckersley | Dennis Eckersley | Dennis Martinez | Mark Clear | 45 | 59 | -14 |
| 1982-04-23 | vs CHA | 12 | L 2-4 | 2-10 | 7 | 11,885 | Jim Palmer | Britt Burns | LaMarr Hoyt | Jim Palmer | Jerry Koosman | 47 | 63 | -16 |
| 1982-04-24 | vs CHA | 13 | W 7-4 | 3-10 | 7 | 24,749 | Scott McGregor | Dennis Lamp | Sammy Stewart | Kevin Hickey | | 54 | 67 | -13 |
| 1982-04-25 | vs CHA | 14 | W 2-1 | 4-10 | 7 | 16,233 | Dennis Martinez | Steve Trout | Dennis Martinez | Steve Trout | Tippy Martinez | 56 | 68 | -12 |
| 1982-04-28 | vs OAK | 15 | L 2-6 | 5-11 | 7 | 0 | Mike Flanagan | Mike Norris | Mike Norris | Mike Flanagan | | 58 | 74 | -16 |
| 1982-04-28 | vs OAK | 16 | W 5-1 | 5-11 | 7 | 11,859 | Scott McGregor | Matt Keough | Scott McGregor | Matt Keough | | 63 | 75 | -12 |
| 1982-04-29 | vs OAK | 17 | L 6-9 | 5-12 | 7 | 10,990 | Dennis Martinez | Steve McCatty | Dave Beard | Tippy Martinez | | 69 | 84 | -15 |
| 1982-04-30 | vs CAL | 18 | W 9-4 | 6-12 | 7 | 15,877 | Jim Palmer | Mike Witt | Jim Palmer | Stan Bahnsen | | 78 | 88 | -10 |
| 1982-05-01 | vs CAL | 19 | L 4-6 | 6-13 | 7 | 23,276 | Sammy Stewart | Ken Forsch | Don Aase | Tippy Martinez | | 82 | 94 | -12 |
| 1982-05-02 | vs CAL | 20 | W 6-4 | 7-13 | 7 | 27,128 | Scott McGregor | Angel Moreno | Scott McGregor | Angel Moreno | | 88 | 98 | -10 |
| 1982-05-03 | vs SEA | 21 | W 6-0 | 8-13 | 6 | 9,241 | Mike Flanagan | Mike Moore | Mike Flanagan | Mike Moore | | 94 | 98 | -4 |
| 1982-05-04 | vs SEA | 22 | L 3-4 | 8-14 | 7 | 8,040 | Dennis Martinez | Gene Nelson | Gene Nelson | Sammy Stewart | Ed Vande Berg | 97 | 102 | -5 |
| 1982-05-06 | @ CAL | 23 | W 9-2 | 9-14 | 4 | 25,006 | Jim Palmer | Ken Forsch | Ross Grimsley | Don Aase | | 106 | 104 | 2 |
| 1982-05-07 | @ CAL | 24 | W 5-3 | 10-14 | 4 | 29,572 | Scott McGregor | Angel Moreno | Scott McGregor | Angel Moreno | Tippy Martinez | 111 | 107 | 4 |
| 1982-05-08 | @ CAL | 25 | L 2-7 | 10-15 | 6 | 48,016 | Mike Flanagan | Steve Renko | Steve Renko | Mike Flanagan | Don Aase | 113 | 114 | -1 |
| 1982-05-09 | @ CAL | 26 | L 4-8 | 10-16 | 7 | 39,417 | Dennis Martinez | Bruce Kison | Bruce Kison | Dennis Martinez | | 117 | 122 | -5 |
| 1982-05-10 | @ OAK | 27 | L 6-7 | 10-17 | 7 | 23,805 | Sammy Stewart | Steve McCatty | Dave Beard | Ross Grimsley | | 123 | 129 | -6 |
| 1982-05-11 | @ OAK | 28 | W 7-1 | 11-17 | 7 | 10,750 | Scott McGregor | Rick Langford | Scott McGregor | Rick Langford | | 130 | 130 | 0 |
| 1982-05-12 | @ OAK | 29 | L 4-5 | 11-18 | 7 | 18,179 | Mike Flanagan | Mike Norris | Dave Beard | Tim Stoddard | | 134 | 135 | -1 |
| 1982-05-13 | @ SEA | 30 | W 3-1 | 12-18 | 7 | 5,304 | Dennis Martinez | Jim Beattie | Dennis Martinez | Jim Beattie | | 137 | 136 | 1 |
| 1982-05-14 | @ SEA | 31 | W 11-4 | 13-18 | 6 | 6,489 | Sammy Stewart | Gene Nelson | Sammy Stewart | Gene Nelson | Jim Palmer | 148 | 140 | 8 |
| 1982-05-15 | @ SEA | 32 | L 2-3 | 13-19 | 7 | 23,682 | Scott McGregor | Mike Moore | Bill Caudill | Scott McGregor | | 150 | 143 | 7 |
| 1982-05-16 | @ SEA | 33 | W 5-4 | 14-19 | 5 | 6,504 | Mike Flanagan | Gaylord Perry | Tippy Martinez | Gaylord Perry | Tim Stoddard | 155 | 147 | 8 |
| 1982-05-18 | vs MIN | 34 | L 7-8 | 14-20 | 6 | 10,998 | Dennis Martinez | Albert Williams | Bobby Castillo | Jim Palmer | Ron Davis | 162 | 155 | 7 |
| 1982-05-19 | vs MIN | 35 | W 4-2 | 15-20 | 5 | 8,088 | Sammy Stewart | Pete Filson | Sammy Stewart | Pete Filson | Tim Stoddard | 166 | 157 | 9 |
| 1982-05-20 | vs MIN | 36 | W 6-0 | 16-20 | 5 | 12,598 | Scott McGregor | Pete Redfern | Scott McGregor | Pete Redfern | | 172 | 157 | 15 |
| 1982-05-21 | @ TOR | 37 | W 3-0 | 17-20 | 5 | 12,387 | Mike Flanagan | Jim Gott | Mike Flanagan | Jim Gott | Tippy Martinez | 175 | 157 | 18 |
| 1982-05-22 | @ TOR | 38 | W 6-0 | 18-20 | 5 | 17,457 | Dennis Martinez | Dave Stieb | Dennis Martinez | Dave Stieb | | 181 | 157 | 24 |
| 1982-05-23 | @ TOR | 39 | L 1-7 | 18-21 | 5 | 14,229 | Sammy Stewart | Luis Leal | Luis Leal | Sammy Stewart | | 182 | 164 | 18 |
| 1982-05-24 | @ TOR | 40 | W 7-5 | 19-21 | 5 | 12,088 | Scott McGregor | Jim Clancy | Scott McGregor | Jim Clancy | Tim Stoddard | 189 | 169 | 20 |
| 1982-05-25 | @ TEX | 41 | W 10-3 | 20-21 | 5 | 12,021 | Jim Palmer | Doc Medich | Jim Palmer | Doc Medich | | 199 | 172 | 27 |
| 1982-05-26 | @ TEX | 42 | L 3-5 | 20-22 | 5 | 8,929 | Dennis Martinez | Jon Matlack | Jon Matlack | Dennis Martinez | Paul Mirabella | 202 | 177 | 25 |
| 1982-05-27 | @ TEX | 43 | W 6-0 | 21-22 | 5 | 9,785 | Sammy Stewart | Frank Tanana | Sammy Stewart | Frank Tanana | | 208 | 177 | 31 |
| 1982-05-29 | vs TOR | 44 | W 3-1 | 22-23 | 4 | 0 | Mike Flanagan | Luis Leal | Mike Flanagan | Luis Leal | | 211 | 178 | 33 |
| 1982-05-29 | vs TOR | 45 | L 10-11 | 22-23 | 4 | 21,241 | Scott McGregor | Jim Clancy | Joey McLaughlin | Tim Stoddard | | 221 | 189 | 32 |
| 1982-05-30 | vs TOR | 46 | L 0-6 | 22-24 | 6 | 21,632 | Jim Palmer | Jim Gott | Jim Gott | Jim Palmer | Roy Lee Jackson | 221 | 195 | 26 |
| 1982-05-31 | vs TEX | 47 | W 8-7 | 23-24 | 5 | 13,344 | Dennis Martinez | Jon Matlack | Dennis Martinez | Jon Matlack | Tippy Martinez | 229 | 202 | 27 |
| 1982-06-02 | vs TEX | 48 | L 1-4 | 23-25 | 6 | 10,469 | Sammy Stewart | Frank Tanana | Frank Tanana | Sammy Stewart | | 230 | 206 | 24 |
| 1982-06-04 | @ MIN | 49 | L 0-6 | 23-26 | 6 | 8,517 | Scott McGregor | Brad Havens | Brad Havens | Scott McGregor | Terry Felton | 230 | 212 | 18 |
| 1982-06-05 | @ MIN | 50 | W 3-1 | 24-26 | 6 | 11,151 | Mike Flanagan | Albert Williams | Mike Flanagan | Albert Williams | | 233 | 213 | 20 |
| 1982-06-06 | @ MIN | 51 | W 7-5 | 25-26 | 6 | 11,240 | Dennis Martinez | Frank Viola | Tim Stoddard | Ron Davis | | 240 | 218 | 22 |
| 1982-06-07 | @ MIL | 52 | W 7-2 | 26-26 | 5 | 15,017 | Jim Palmer | Mike Caldwell | Jim Palmer | Mike Caldwell | | 247 | 220 | 27 |
| 1982-06-08 | @ MIL | 53 | W 4-2 | 27-26 | 3 | 13,517 | Scott McGregor | Randy Lerch | Scott McGregor | Randy Lerch | | 251 | 222 | 29 |
| 1982-06-09 | @ MIL | 54 | W 8-3 | 28-26 | 3 | 13,662 | Mike Flanagan | Moose Haas | Mike Flanagan | Moose Haas | | 259 | 225 | 34 |
| 1982-06-10 | @ MIL | 55 | L 7-9 | 28-27 | 3 | 22,013 | Sammy Stewart | Bob McClure | Rollie Fingers | Tippy Martinez | | 266 | 234 | 32 |
| 1982-06-11 | vs NYA | 56 | W 9-4 | 29-27 | 3 | 32,515 | Dennis Martinez | Mike Morgan | Dennis Martinez | Mike Morgan | Tippy Martinez | 275 | 238 | 37 |
| 1982-06-12 | vs NYA | 57 | W 5-3 | 30-27 | 3 | 34,354 | Jim Palmer | Roger Erickson | Tippy Martinez | Shane Rawley | Tim Stoddard | 280 | 241 | 39 |
| 1982-06-14 | vs MIL | 58 | W 9-4 | 31-27 | 3 | 19,234 | Scott McGregor | Moose Haas | Scott McGregor | Moose Haas | | 289 | 245 | 44 |
| 1982-06-15 | vs MIL | 59 | L 3-6 | 31-28 | 3 | 18,420 | Mike Flanagan | Bob McClure | Bob McClure | Mike Flanagan | Jim Slaton | 292 | 251 | 41 |
| 1982-06-16 | vs MIL | 60 | W 2-2 | 32-28 | 3 | 13,213 | Dennis Martinez | Pete Vuckovich | | | | 294 | 253 | 41 |
| 1982-06-18 | @ NYA | 61 | W 4-1 | 33-28 | 3 | 35,199 | Jim Palmer | Mike Morgan | Jim Palmer | Mike Morgan | Tippy Martinez | 298 | 254 | 44 |
| 1982-06-19 | @ NYA | 62 | L 3-4 | 33-29 | 3 | 35,377 | Scott McGregor | Ron Guidry | Dave LaRoche | Storm Davis | | 301 | 258 | 43 |
| 1982-06-20 | @ NYA | 63 | W 5-3 | 34-29 | 3 | 46,127 | Mike Flanagan | Tommy John | Tippy Martinez | Rich Gossage | | 306 | 261 | 45 |
| 1982-06-21 | @ CLE | 64 | W 7-0 | 35-29 | 3 | 10,633 | Dennis Martinez | Rick Waits | Dennis Martinez | Rick Waits | | 313 | 261 | 52 |
| 1982-06-22 | @ CLE | 65 | L 6-8 | 35-30 | 4 | 7,400 | Sammy Stewart | Lary Sorensen | Lary Sorensen | Sammy Stewart | | 319 | 269 | 50 |
| 1982-06-23 | @ CLE | 66 | W 3-1 | 36-30 | 3 | 14,005 | Jim Palmer | John Denny | Jim Palmer | John Denny | Tim Stoddard | 322 | 270 | 52 |
| 1982-06-24 | vs DET | 67 | L 1-7 | 36-31 | 4 | 27,191 | Scott McGregor | Jerry Ujdur | Jerry Ujdur | Scott McGregor | | 323 | 277 | 46 |
| 1982-06-25 | vs DET | 68 | W 5-2 | 37-31 | 4 | 25,230 | Mike Flanagan | Dan Petry | Mike Flanagan | Dan Petry | Tim Stoddard | 328 | 279 | 49 |
| 1982-06-26 | vs DET | 69 | W 4-1 | 38-31 | 3 | 31,859 | Dennis Martinez | Milt Wilcox | Dennis Martinez | Milt Wilcox | | 332 | 280 | 52 |
| 1982-06-27 | vs DET | 70 | W 13-1 | 39-31 | 3 | 43,938 | Jim Palmer | Jack Morris | Jim Palmer | Jack Morris | | 345 | 281 | 64 |
| 1982-06-29 | vs CLE | 71 | L 2-9 | 39-32 | 3 | 12,551 | Scott McGregor | John Denny | John Denny | Scott McGregor | | 347 | 290 | 57 |
| 1982-06-30 | vs CLE | 72 | L 0-9 | 39-33 | 3 | 14,259 | Mike Flanagan | Rick Sutcliffe | Rick Sutcliffe | Mike Flanagan | | 347 | 299 | 48 |
| 1982-07-01 | vs CLE | 73 | L 2-6 | 39-34 | 4 | 23,642 | Dennis Martinez | Len Barker | Len Barker | Dennis Martinez | Dan Spillner | 349 | 305 | 44 |
| 1982-07-02 | @ DET | 74 | W 5-4 | 40-34 | 3 | 26,477 | Jim Palmer | Jack Morris | Jim Palmer | Pat Underwood | Tim Stoddard | 354 | 309 | 45 |
| 1982-07-03 | @ DET | 75 | W 8-3 | 41-34 | 3 | 24,782 | Storm Davis | Jerry Ujdur | Storm Davis | Jerry Ujdur | | 362 | 312 | 50 |
| 1982-07-04 | @ DET | 76 | L 1-6 | 41-35 | 3 | 15,880 | Mike Flanagan | Dan Petry | Dan Petry | Mike Flanagan | | 363 | 318 | 45 |
| 1982-07-05 | @ CAL | 77 | W 8-5 | 42-35 | 3 | 27,571 | Scott McGregor | Ken Forsch | Scott McGregor | Ken Forsch | Tippy Martinez | 371 | 323 | 48 |
| 1982-07-06 | @ CAL | 78 | W 3-2 | 43-35 | 3 | 24,035 | Dennis Martinez | Steve Renko | Dennis Martinez | Doug Corbett | Tippy Martinez | 374 | 325 | 49 |
| 1982-07-07 | @ SEA | 79 | L 7-8 | 43-36 | 3 | 12,405 | Storm Davis | Gene Nelson | Bill Caudill | Tim Stoddard | | 381 | 333 | 48 |
| 1982-07-08 | @ SEA | 80 | L 3-4 | 43-37 | 3 | 13,538 | Mike Flanagan | Mike Moore | Mike Moore | Mike Flanagan | Bill Caudill | 384 | 337 | 47 |
| 1982-07-09 | @ OAK | 81 | W 7-5 | 44-37 | 3 | 16,051 | Scott McGregor | Matt Keough | Scott McGregor | Matt Keough | Tim Stoddard | 391 | 342 | 49 |
| 1982-07-10 | @ OAK | 82 | L 1-3 | 44-38 | 3 | 25,656 | Dennis Martinez | Tom Underwood | Tom Underwood | Dennis Martinez | Dave Beard | 392 | 345 | 47 |
| 1982-07-11 | @ OAK | 83 | W 8-7 | 45-38 | 3 | 23,484 | Storm Davis | Brian Kingman | Storm Davis | Brian Kingman | Tim Stoddard | 400 | 352 | 48 |
| 1982-07-15 | vs SEA | 84 | W 3-2 | 46-38 | 3 | 14,592 | Scott McGregor | Jim Beattie | Scott McGregor | Jim Beattie | Sammy Stewart | 403 | 354 | 49 |
| 1982-07-16 | vs SEA | 85 | L 0-6 | 46-39 | 3 | 13,259 | Dennis Martinez | Floyd Bannister | Floyd Bannister | Dennis Martinez | | 403 | 360 | 43 |
| 1982-07-17 | vs SEA | 86 | W 8-4 | 47-39 | 3 | 21,082 | Mike Flanagan | Gaylord Perry | Storm Davis | Gaylord Perry | | 411 | 364 | 47 |
| 1982-07-18 | vs SEA | 87 | W 4-3 | 48-39 | 3 | 15,169 | Jim Palmer | Mike Moore | Sammy Stewart | Mike Moore | | 415 | 367 | 48 |
| 1982-07-19 | vs CAL | 88 | L 5-6 | 48-40 | 3 | 23,146 | Scott McGregor | Steve Renko | Steve Renko | Scott McGregor | Bruce Kison | 420 | 373 | 47 |
| 1982-07-20 | vs CAL | 89 | L 4-7 | 48-41 | 3 | 16,601 | Dennis Martinez | Dave Goltz | Dave Goltz | Dennis Martinez | Andy Hassler | 424 | 380 | 44 |
| 1982-07-21 | vs CAL | 90 | W 8-7 | 49-41 | 3 | 20,570 | Mike Flanagan | Ken Forsch | Sammy Stewart | Andy Hassler | Tippy Martinez | 432 | 387 | 45 |
| 1982-07-23 | vs OAK | 91 | W 2-1 | 50-41 | 3 | 23,303 | Jim Palmer | Matt Keough | Jim Palmer | Matt Keough | Tippy Martinez | 434 | 388 | 46 |
| 1982-07-24 | vs OAK | 92 | W 5-4 | 51-41 | 3 | 21,780 | Scott McGregor | Rick Langford | Tippy Martinez | Bob Owchinko | | 439 | 392 | 47 |
| 1982-07-25 | vs OAK | 93 | W 6-2 | 52-41 | 3 | 23,490 | Dennis Martinez | Brian Kingman | Dennis Martinez | Brian Kingman | | 445 | 394 | 51 |
| 1982-07-26 | vs CHA | 94 | W 6-2 | 53-41 | 3 | 17,763 | Mike Flanagan | Jerry Koosman | Mike Flanagan | Jerry Koosman | Tim Stoddard | 451 | 396 | 55 |
| 1982-07-27 | vs CHA | 95 | W 5-3 | 54-41 | 3 | 12,881 | Jim Palmer | Britt Burns | Tippy Martinez | Kevin Hickey | | 456 | 399 | 57 |
| 1982-07-28 | vs CHA | 96 | W 2-1 | 55-41 | 3 | 14,233 | Scott McGregor | Richard Dotson | Scott McGregor | Richard Dotson | Tippy Martinez | 458 | 400 | 58 |
| 1982-07-29 | @ KCA | 97 | L 2-7 | 55-42 | 3 | 36,217 | Dennis Martinez | Derek Botelho | Derek Botelho | Dennis Martinez | | 460 | 407 | 53 |
| 1982-07-30 | @ KCA | 98 | L 3-4 | 55-43 | 3 | 33,844 | Sammy Stewart | Larry Gura | Larry Gura | Sammy Stewart | Dan Quisenberry | 463 | 411 | 52 |
| 1982-07-31 | @ KCA | 99 | L 0-2 | 55-44 | 3 | 40,771 | Mike Flanagan | Vida Blue | Vida Blue | Mike Flanagan | | 463 | 413 | 50 |
| 1982-08-01 | @ KCA | 100 | L 2-4 | 55-45 | 3 | 30,280 | Jim Palmer | Dave Frost | Bill Castro | Tippy Martinez | Dan Quisenberry | 465 | 417 | 48 |
| 1982-08-02 | vs BOS | 101 | L 2-5 | 55-46 | 3 | 25,010 | Scott McGregor | John Tudor | John Tudor | Scott McGregor | Bob Stanley | 467 | 422 | 45 |
| 1982-08-03 | vs BOS | 102 | W 7-2 | 56-47 | 3 | 0 | Dennis Martinez | Chuck Rainey | Dennis Martinez | Chuck Rainey | | 474 | 424 | 50 |
| 1982-08-03 | vs BOS | 103 | L 6-7 | 56-47 | 3 | 41,076 | Sammy Stewart | Mike Torrez | Mark Clear | Ross Grimsley | | 480 | 431 | 49 |
| 1982-08-04 | vs BOS | 104 | W 4-2 | 57-47 | 3 | 25,625 | Mike Flanagan | Dennis Eckersley | Mike Flanagan | Bob Stanley | Tim Stoddard | 484 | 433 | 51 |
| 1982-08-05 | vs KCA | 105 | W 5-1 | 58-47 | 3 | 20,943 | Jim Palmer | Vida Blue | Jim Palmer | Vida Blue | | 489 | 434 | 55 |
| 1982-08-06 | vs KCA | 106 | L 1-3 | 58-49 | 3 | 0 | Storm Davis | Dave Frost | Dave Frost | Storm Davis | Mike Armstrong | 490 | 437 | 53 |
| 1982-08-06 | vs KCA | 107 | L 0-4 | 58-49 | 3 | 25,768 | Scott McGregor | Don Hood | Don Hood | Scott McGregor | Dan Quisenberry | 490 | 441 | 49 |
| 1982-08-07 | vs KCA | 108 | W 6-5 | 59-49 | 3 | 39,649 | Dennis Martinez | Buddy Black | Tippy Martinez | Dan Quisenberry | | 496 | 446 | 50 |
| 1982-08-08 | vs KCA | 109 | W 10-6 | 60-49 | 3 | 26,099 | Mike Flanagan | Dennis Leonard | Tim Stoddard | Mike Armstrong | | 506 | 452 | 54 |
| 1982-08-09 | @ CHA | 110 | L 5-9 | 60-50 | 3 | 26,765 | Jim Palmer | LaMarr Hoyt | Kevin Hickey | Tippy Martinez | | 511 | 461 | 50 |
| 1982-08-10 | @ CHA | 111 | L 4-9 | 60-51 | 3 | 19,676 | Scott McGregor | Britt Burns | Britt Burns | Scott McGregor | | 515 | 470 | 45 |
| 1982-08-11 | @ CHA | 112 | L 1-4 | 60-52 | 3 | 19,481 | Dennis Martinez | Richard Dotson | Richard Dotson | Dennis Martinez | Dennis Lamp | 516 | 474 | 42 |
| 1982-08-13 | @ BOS | 113 | L 2-5 | 60-53 | 3 | 32,935 | Mike Flanagan | John Tudor | John Tudor | Mike Flanagan | | 518 | 479 | 39 |
| 1982-08-14 | @ BOS | 114 | W 5-2 | 61-53 | 3 | 31,343 | Jim Palmer | Dennis Eckersley | Tippy Martinez | Mark Clear | | 523 | 481 | 42 |
| 1982-08-15 | @ BOS | 115 | L 0-8 | 61-54 | 3 | 30,675 | Scott McGregor | Mike Torrez | Bob Stanley | Scott McGregor | | 523 | 489 | 34 |
| 1982-08-16 | @ BOS | 116 | L 4-9 | 61-55 | 3 | 34,746 | Dennis Martinez | Chuck Rainey | Tom Burgmeier | Storm Davis | | 527 | 498 | 29 |
| 1982-08-17 | @ MIN | 117 | W 8-4 | 62-55 | 3 | 8,407 | Mike Flanagan | Jack O'Connor | Mike Flanagan | Jack O'Connor | | 535 | 502 | 33 |
| 1982-08-18 | @ MIN | 118 | L 5-6 | 62-56 | 3 | 7,132 | Jim Palmer | Frank Viola | Ron Davis | Tim Stoddard | | 540 | 508 | 32 |
| 1982-08-19 | @ MIN | 119 | L 3-9 | 62-57 | 3 | 15,529 | Scott McGregor | Bobby Castillo | Bobby Castillo | Scott McGregor | | 543 | 517 | 26 |
| 1982-08-20 | @ TEX | 120 | W 4-2 | 63-57 | 3 | 11,945 | Dennis Martinez | John Butcher | Tippy Martinez | Steve Comer | Sammy Stewart | 547 | 519 | 28 |
| 1982-08-21 | @ TEX | 121 | W 8-6 | 64-57 | 3 | 13,012 | Mike Flanagan | Charlie Hough | Tim Stoddard | Jon Matlack | | 555 | 525 | 30 |
| 1982-08-22 | @ TEX | 122 | W 10-3 | 65-57 | 3 | 9,848 | Jim Palmer | Rick Honeycutt | Jim Palmer | Rick Honeycutt | | 565 | 528 | 37 |
| 1982-08-24 | vs TOR | 123 | W 7-3 | 66-57 | 3 | 12,139 | Dennis Martinez | Dave Stieb | Dennis Martinez | Joey McLaughlin | | 572 | 531 | 41 |
| 1982-08-25 | vs TOR | 124 | W 8-3 | 67-57 | 3 | 11,712 | Mike Flanagan | Jim Clancy | Mike Flanagan | Jim Clancy | | 580 | 534 | 46 |
| 1982-08-26 | vs TOR | 125 | W 12-5 | 68-57 | 3 | 21,471 | Scott McGregor | Jim Gott | Storm Davis | Jim Gott | | 592 | 539 | 53 |
| 1982-08-27 | vs TEX | 126 | W 3-1 | 69-58 | 2 | 0 | Jim Palmer | Mike Smithson | Jim Palmer | Mike Smithson | Tim Stoddard | 595 | 540 | 55 |
| 1982-08-27 | vs TEX | 127 | L 3-4 | 69-58 | 2 | 20,368 | Sammy Stewart | Steve Comer | Steve Comer | Sammy Stewart | | 598 | 544 | 54 |
| 1982-08-28 | vs TEX | 128 | W 8-3 | 70-58 | 2 | 23,630 | Dennis Martinez | Dave J. Schmidt | Dennis Martinez | Dave J. Schmidt | | 606 | 547 | 59 |
| 1982-08-29 | vs TEX | 129 | W 3-2 | 71-58 | 2 | 25,393 | Mike Flanagan | Frank Tanana | Mike Flanagan | Frank Tanana | | 609 | 549 | 60 |
| 1982-08-30 | @ TOR | 130 | W 6-3 | 72-58 | 2 | 14,091 | Storm Davis | Mark Eichhorn | Storm Davis | Mark Eichhorn | Tippy Martinez | 615 | 552 | 63 |
| 1982-08-31 | @ TOR | 131 | W 1-0 | 73-58 | 2 | 14,690 | Jim Palmer | Luis Leal | Jim Palmer | Luis Leal | | 616 | 552 | 64 |
| 1982-09-01 | @ TOR | 132 | W 5-2 | 74-58 | 2 | 12,473 | Dennis Martinez | Dave Stieb | Dennis Martinez | Dave Stieb | | 621 | 554 | 67 |
| 1982-09-03 | vs MIN | 133 | W 4-2 | 75-58 | 2 | 23,473 | Mike Flanagan | Jack O'Connor | Mike Flanagan | Jack O'Connor | | 625 | 556 | 69 |
| 1982-09-04 | vs MIN | 134 | W 3-0 | 76-58 | 2 | 19,536 | Jim Palmer | Bobby Castillo | Jim Palmer | Bobby Castillo | | 628 | 556 | 72 |
| 1982-09-05 | vs MIN | 135 | W 5-4 | 77-58 | 2 | 23,089 | Dennis Martinez | Frank Viola | Storm Davis | Pete Redfern | | 633 | 560 | 73 |
| 1982-09-06 | @ NYA | 136 | W 8-2 | 78-58 | 2 | 32,537 | Scott McGregor | Dave Righetti | Scott McGregor | Dave Righetti | Sammy Stewart | 641 | 562 | 79 |
| 1982-09-07 | @ NYA | 137 | W 7-2 | 79-58 | 2 | 15,405 | Mike Flanagan | Mike Morgan | Mike Flanagan | Mike Morgan | | 648 | 564 | 84 |
| 1982-09-08 | @ NYA | 138 | L 5-10 | 79-59 | 2 | 20,898 | Jim Palmer | Jay Howell | Jay Howell | Jim Palmer | | 653 | 574 | 79 |
| 1982-09-09 | @ CLE | 139 | L 0-3 | 79-60 | 2 | 4,279 | Dennis Martinez | John Denny | Bud Anderson | Dennis Martinez | | 653 | 577 | 76 |
| 1982-09-10 | @ CLE | 140 | W 3-2 | 80-60 | 2 | 8,374 | Scott McGregor | Len Barker | Sammy Stewart | Dan Spillner | | 656 | 579 | 77 |
| 1982-09-11 | @ CLE | 141 | W 8-1 | 81-60 | 2 | 8,827 | Mike Flanagan | Lary Sorensen | Mike Flanagan | Lary Sorensen | | 664 | 580 | 84 |
| 1982-09-12 | @ CLE | 142 | L 0-3 | 81-61 | 2 | 7,860 | Jim Palmer | Rick Sutcliffe | Rick Sutcliffe | Tippy Martinez | | 664 | 583 | 81 |
| 1982-09-13 | vs NYA | 143 | W 8-7 | 82-61 | 2 | 18,892 | Dennis Martinez | Jay Howell | Mike Boddicker | Rudy May | Tippy Martinez | 672 | 590 | 82 |
| 1982-09-14 | vs NYA | 144 | W 5-4 | 84-61 | 2 | 0 | Scott McGregor | Shane Rawley | John Flinn | Shane Rawley | Tippy Martinez | 677 | 594 | 83 |
| 1982-09-14 | vs NYA | 145 | W 5-3 | 84-61 | 2 | 28,094 | Storm Davis | Mike Morgan | Storm Davis | Mike Morgan | Tippy Martinez | 682 | 597 | 85 |
| 1982-09-15 | vs NYA | 146 | W 8-5 | 85-61 | 2 | 22,861 | Mike Flanagan | Ron Guidry | Don Welchel | Ron Guidry | Sammy Stewart | 690 | 602 | 88 |
| 1982-09-16 | vs NYA | 147 | W 3-1 | 86-61 | 1 | 25,089 | Jim Palmer | Dave Righetti | Jim Palmer | Dave Righetti | | 693 | 603 | 90 |
| 1982-09-17 | vs CLE | 148 | L 3-5 | 86-62 | 2 | 14,924 | Dennis Martinez | Rick Sutcliffe | Rick Sutcliffe | Dennis Martinez | Ed Glynn | 696 | 608 | 88 |
| 1982-09-18 | vs CLE | 149 | W 5-2 | 87-62 | 2 | 23,172 | Scott McGregor | Bud Anderson | Scott McGregor | Bud Anderson | | 701 | 610 | 91 |
| 1982-09-19 | vs CLE | 150 | W 4-2 | 88-62 | 2 | 41,127 | Mike Flanagan | Neal Heaton | Mike Flanagan | Ed Glynn | | 705 | 612 | 93 |
| 1982-09-20 | vs DET | 151 | W 3-1 | 89-62 | 2 | 8,246 | Jim Palmer | Jack Morris | Sammy Stewart | Jack Morris | | 708 | 613 | 95 |
| 1982-09-21 | vs DET | 152 | L 1-11 | 89-63 | 2 | 10,522 | Storm Davis | Milt Wilcox | Milt Wilcox | Storm Davis | | 709 | 624 | 85 |
| 1982-09-23 | vs DET | 153 | L 5-10 | 89-64 | 2 | 8,633 | Scott McGregor | Dan Petry | Dave Rucker | Sammy Stewart | | 714 | 634 | 80 |
| 1982-09-24 | @ MIL | 154 | L 6-15 | 89-65 | 2 | 38,950 | Mike Flanagan | Don Sutton | Don Sutton | Mike Flanagan | | 720 | 649 | 71 |
| 1982-09-25 | @ MIL | 155 | W 7-2 | 90-65 | 2 | 53,568 | Jim Palmer | Pete Vuckovich | Jim Palmer | Pete Vuckovich | | 727 | 651 | 76 |
| 1982-09-26 | @ MIL | 156 | W 5-2 | 91-65 | 2 | 48,161 | Dennis Martinez | Mike Caldwell | Dennis Martinez | Mike Caldwell | Tippy Martinez | 732 | 653 | 79 |
| 1982-09-28 | @ DET | 157 | L 6-9 | 91-66 | 2 | 7,755 | Scott McGregor | Dan Petry | Dave Rucker | Sammy Stewart | | 738 | 662 | 76 |
| 1982-09-29 | @ DET | 158 | L 2-3 | 91-67 | 2 | 8,897 | Jim Palmer | Jerry Ujdur | Dave Tobik | Tippy Martinez | | 740 | 665 | 75 |
| 1982-09-30 | @ DET | 159 | W 6-5 | 92-67 | 2 | 11,049 | Mike Flanagan | Jack Morris | John Flinn | Dave Tobik | | 746 | 670 | 76 |
| 1982-10-01 | vs MIL | 160 | W 8-3 | 94-67 | 1 | 0 | Dennis Martinez | Pete Vuckovich | Dennis Martinez | Pete Vuckovich | | 754 | 673 | 81 |
| 1982-10-01 | vs MIL | 161 | W 7-1 | 94-67 | 1 | 51,883 | Storm Davis | Mike Caldwell | Storm Davis | Mike Caldwell | | 761 | 674 | 87 |
| 1982-10-02 | vs MIL | 162 | W 11-3 | 95-67 | 1 | 47,235 | Scott McGregor | Doc Medich | Sammy Stewart | Doc Medich | | 772 | 677 | 95 |
| 1982-10-03 | vs MIL | 163 | L 2-10 | 95-68 | 1 | 51,642 | Jim Palmer | Don Sutton | Don Sutton | Jim Palmer | | 774 | 687 | 87 |