| 1982-04-06 | @ OAK | 1 | L 2-3 | 0-1 | 7 | 51,513 | Ken Forsch | Rick Langford | Jeff Jones | Don Aase | | 2 | 3 | -1 |
| 1982-04-07 | @ OAK | 2 | W 7-0 | 1-1 | 4 | 17,576 | Geoff Zahn | Mike Norris | Geoff Zahn | Mike Norris | | 9 | 3 | 6 |
| 1982-04-08 | @ OAK | 3 | W 8-6 | 2-1 | 2 | 17,806 | Mike Witt | Matt Keough | Luis Sanchez | Jeff Jones | | 17 | 9 | 8 |
| 1982-04-09 | @ MIN | 4 | L 1-2 | 2-2 | 4 | 19,105 | Angel Moreno | Albert Williams | Albert Williams | Angel Moreno | | 18 | 11 | 7 |
| 1982-04-10 | @ MIN | 5 | W 8-1 | 3-2 | 4 | 23,769 | Bruce Kison | Darrell Jackson | Steve Renko | Darrell Jackson | | 26 | 12 | 14 |
| 1982-04-11 | @ MIN | 6 | L 1-3 | 3-3 | 6 | 12,710 | Ken Forsch | Pete Redfern | Pete Redfern | Ken Forsch | | 27 | 15 | 12 |
| 1982-04-13 | vs SEA | 7 | W 4-3 | 4-3 | 5 | 33,574 | Geoff Zahn | Jim Beattie | Luis Sanchez | Gene Nelson | | 31 | 18 | 13 |
| 1982-04-14 | vs SEA | 8 | W 2-1 | 5-3 | 4 | 23,905 | Mike Witt | Gene Nelson | Steve Renko | Ed Vande Berg | | 33 | 19 | 14 |
| 1982-04-15 | vs SEA | 9 | W 3-2 | 6-3 | 3 | 22,410 | Angel Moreno | Gaylord Perry | Angel Moreno | Gaylord Perry | | 36 | 21 | 15 |
| 1982-04-16 | vs MIN | 10 | W 4-2 | 7-3 | 3 | 24,723 | Bruce Kison | Darrell Jackson | Don Aase | Doug Corbett | | 40 | 23 | 17 |
| 1982-04-17 | vs MIN | 11 | W 6-2 | 8-3 | 3 | 61,640 | Ken Forsch | Terry Felton | Ken Forsch | Terry Felton | | 46 | 25 | 21 |
| 1982-04-18 | vs MIN | 12 | W 5-2 | 9-3 | 2 | 26,935 | Geoff Zahn | Roger Erickson | Geoff Zahn | Roger Erickson | | 51 | 27 | 24 |
| 1982-04-19 | @ SEA | 13 | W 3-1 | 10-3 | 2 | 5,494 | Mike Witt | Gene Nelson | Mike Witt | Gene Nelson | Don Aase | 54 | 28 | 26 |
| 1982-04-20 | @ SEA | 14 | L 4-6 | 10-4 | 2 | 7,419 | Angel Moreno | Gaylord Perry | Gaylord Perry | Angel Moreno | Mike Stanton | 58 | 34 | 24 |
| 1982-04-21 | @ SEA | 15 | L 3-5 | 10-5 | 2 | 4,961 | Bruce Kison | Floyd Bannister | Floyd Bannister | Steve Renko | Bill Caudill | 61 | 39 | 22 |
| 1982-04-23 | vs OAK | 16 | W 7-2 | 11-5 | 2 | 36,585 | Ken Forsch | Matt Keough | Ken Forsch | Matt Keough | | 68 | 41 | 27 |
| 1982-04-24 | vs OAK | 17 | W 4-2 | 12-5 | 2 | 58,963 | Geoff Zahn | Steve McCatty | Geoff Zahn | Steve McCatty | Don Aase | 72 | 43 | 29 |
| 1982-04-25 | vs OAK | 18 | W 5-1 | 13-5 | 1 | 35,781 | Mike Witt | Rick Langford | Mike Witt | Rick Langford | | 77 | 44 | 33 |
| 1982-04-27 | @ NYA | 19 | W 3-1 | 14-5 | 1 | 35,458 | Angel Moreno | Ron Guidry | Angel Moreno | Ron Guidry | | 80 | 45 | 35 |
| 1982-04-28 | @ NYA | 20 | L 0-6 | 14-6 | 1 | 25,498 | Ken Forsch | Tommy John | Tommy John | Ken Forsch | | 80 | 51 | 29 |
| 1982-04-29 | @ NYA | 21 | W 2-0 | 15-6 | 1 | 25,350 | Geoff Zahn | Dave Righetti | Geoff Zahn | Shane Rawley | | 82 | 51 | 31 |
| 1982-04-30 | @ BAL | 22 | L 4-9 | 15-7 | 1 | 15,877 | Mike Witt | Jim Palmer | Jim Palmer | Stan Bahnsen | | 86 | 60 | 26 |
| 1982-05-01 | @ BAL | 23 | W 6-4 | 16-7 | 1 | 23,276 | Ken Forsch | Sammy Stewart | Don Aase | Tippy Martinez | | 92 | 64 | 28 |
| 1982-05-02 | @ BAL | 24 | L 4-6 | 16-8 | 1 | 27,128 | Angel Moreno | Scott McGregor | Scott McGregor | Angel Moreno | | 96 | 70 | 26 |
| 1982-05-03 | @ CLE | 25 | W 5-4 | 17-8 | 1 | 6,844 | Mike Witt | Len Barker | Don Aase | Dan Spillner | | 101 | 74 | 27 |
| 1982-05-04 | @ CLE | 26 | L 5-6 | 17-9 | 1 | 5,435 | Geoff Zahn | Lary Sorensen | Lary Sorensen | Geoff Zahn | Dan Spillner | 106 | 80 | 26 |
| 1982-05-06 | vs BAL | 27 | L 2-9 | 17-10 | 1 | 25,006 | Ken Forsch | Jim Palmer | Ross Grimsley | Don Aase | | 108 | 89 | 19 |
| 1982-05-07 | vs BAL | 28 | L 3-5 | 17-11 | 2 | 29,572 | Angel Moreno | Scott McGregor | Scott McGregor | Angel Moreno | Tippy Martinez | 111 | 94 | 17 |
| 1982-05-08 | vs BAL | 29 | W 7-2 | 18-11 | 2 | 48,016 | Steve Renko | Mike Flanagan | Steve Renko | Mike Flanagan | Don Aase | 118 | 96 | 22 |
| 1982-05-09 | vs BAL | 30 | W 8-4 | 19-11 | 2 | 39,417 | Bruce Kison | Dennis Martinez | Bruce Kison | Dennis Martinez | | 126 | 100 | 26 |
| 1982-05-10 | vs NYA | 31 | W 2-1 | 20-11 | 2 | 32,138 | Geoff Zahn | Rudy May | Geoff Zahn | Rudy May | | 128 | 101 | 27 |
| 1982-05-11 | vs NYA | 32 | L 2-3 | 20-12 | 2 | 37,413 | Ken Forsch | Dave Righetti | Dave Righetti | Ken Forsch | Rich Gossage | 130 | 104 | 26 |
| 1982-05-12 | vs NYA | 33 | L 5-6 | 20-13 | 2 | 41,859 | Angel Moreno | Mike Morgan | Shane Rawley | Angel Moreno | Rich Gossage | 135 | 110 | 25 |
| 1982-05-13 | vs CLE | 34 | W 3-2 | 21-13 | 2 | 21,459 | Steve Renko | Len Barker | Andy Hassler | Dan Spillner | | 138 | 112 | 26 |
| 1982-05-14 | vs CLE | 35 | W 5-2 | 22-13 | 2 | 26,862 | Bruce Kison | Lary Sorensen | Bruce Kison | Lary Sorensen | Doug Corbett | 143 | 114 | 29 |
| 1982-05-15 | vs CLE | 36 | W 9-6 | 23-13 | 1 | 41,557 | Geoff Zahn | John Bohnet | Mike Witt | Tom Brennan | Doug Corbett | 152 | 120 | 32 |
| 1982-05-16 | vs CLE | 37 | W 3-0 | 24-13 | 1 | 27,054 | Ken Forsch | John Denny | Ken Forsch | John Denny | | 155 | 120 | 35 |
| 1982-05-18 | @ MIL | 38 | W 4-1 | 25-13 | 1 | 9,222 | Steve Renko | Mike Caldwell | Steve Renko | Mike Caldwell | | 159 | 121 | 38 |
| 1982-05-19 | @ MIL | 39 | W 7-2 | 26-13 | 2 | 10,462 | Bruce Kison | Jim Slaton | Bruce Kison | Jim Slaton | | 166 | 123 | 43 |
| 1982-05-20 | @ MIL | 40 | L 1-4 | 26-14 | 2 | 17,870 | Geoff Zahn | Moose Haas | Moose Haas | Geoff Zahn | | 167 | 127 | 40 |
| 1982-05-21 | @ DET | 41 | W 9-7 | 27-14 | 2 | 37,781 | Ken Forsch | Pat Underwood | Ken Forsch | Pat Underwood | Doug Corbett | 176 | 134 | 42 |
| 1982-05-22 | @ DET | 42 | L 1-5 | 27-15 | 2 | 23,191 | Angel Moreno | Jack Morris | Jack Morris | Angel Moreno | | 177 | 139 | 38 |
| 1982-05-23 | @ DET | 43 | W 7-2 | 28-15 | 2 | 27,344 | Steve Renko | Dan Petry | Steve Renko | Dan Petry | | 184 | 141 | 43 |
| 1982-05-25 | @ BOS | 44 | W 10-2 | 29-15 | 1 | 28,238 | Bruce Kison | John Tudor | Bruce Kison | John Tudor | | 194 | 143 | 51 |
| 1982-05-27 | vs MIL | 45 | L 3-4 | 29-16 | 2 | 24,267 | Ken Forsch | Pete Vuckovich | Pete Vuckovich | Ken Forsch | Rollie Fingers | 197 | 147 | 50 |
| 1982-05-28 | vs MIL | 46 | W 6-5 | 30-16 | 1 | 36,824 | Geoff Zahn | Mike Caldwell | Doug Corbett | Dwight Bernard | | 203 | 152 | 51 |
| 1982-05-29 | vs MIL | 47 | W 5-4 | 31-16 | 1 | 26,620 | Steve Renko | Randy Lerch | Luis Sanchez | Jamie Easterly | | 208 | 156 | 52 |
| 1982-05-30 | vs MIL | 48 | L 3-7 | 31-17 | 1 | 30,270 | Bruce Kison | Jim Slaton | Jim Slaton | Bruce Kison | Jamie Easterly | 211 | 163 | 48 |
| 1982-05-31 | vs DET | 49 | L 3-4 | 31-18 | 1 | 42,415 | Mike Witt | Larry Pashnick | Elias Sosa | Doug Corbett | | 214 | 167 | 47 |
| 1982-06-01 | vs DET | 50 | L 1-2 | 31-19 | 1 | 23,163 | Ken Forsch | Dan Petry | Dan Petry | Ken Forsch | Dave Tobik | 215 | 169 | 46 |
| 1982-06-02 | vs DET | 51 | L 4-5 | 31-20 | 1 | 27,396 | Geoff Zahn | Kevin Saucier | Aurelio Lopez | Doug Corbett | Dave Tobik | 219 | 174 | 45 |
| 1982-06-04 | vs BOS | 52 | L 4-11 | 31-21 | 1 | 33,160 | Steve Renko | Bruce Hurst | Mark Clear | Doug Corbett | | 223 | 185 | 38 |
| 1982-06-05 | vs BOS | 53 | L 2-7 | 31-22 | 1 | 37,885 | Bruce Kison | John Tudor | John Tudor | Bruce Kison | | 225 | 192 | 33 |
| 1982-06-06 | vs BOS | 54 | L 1-5 | 31-23 | 2 | 34,941 | Ken Forsch | Bob Ojeda | Bob Ojeda | Ken Forsch | Mark Clear | 226 | 197 | 29 |
| 1982-06-08 | @ TOR | 55 | W 11-4 | 32-23 | 3 | 16,154 | Geoff Zahn | Jim Gott | Geoff Zahn | Jim Gott | | 237 | 201 | 36 |
| 1982-06-09 | @ TOR | 56 | L 4-5 | 32-24 | 3 | 16,193 | Mike Witt | Jerry Garvin | Joey McLaughlin | Doug Corbett | | 241 | 206 | 35 |
| 1982-06-10 | @ CHA | 57 | L 6-7 | 32-25 | 3 | 20,728 | Steve Renko | Britt Burns | Salome Barojas | Dave Goltz | | 247 | 213 | 34 |
| 1982-06-11 | @ CHA | 58 | W 6-5 | 33-25 | 3 | 32,015 | Bruce Kison | Richard Dotson | Bruce Kison | Richard Dotson | Doug Corbett | 253 | 218 | 35 |
| 1982-06-12 | @ CHA | 59 | W 3-0 | 34-25 | 2 | 44,084 | Ken Forsch | Steve Trout | Ken Forsch | Steve Trout | | 256 | 218 | 38 |
| 1982-06-13 | @ CHA | 60 | W 7-4 | 35-25 | 1 | 50,892 | Geoff Zahn | Dennis Lamp | Geoff Zahn | Dennis Lamp | | 263 | 222 | 41 |
| 1982-06-15 | vs TOR | 61 | L 0-2 | 35-26 | 2 | 23,217 | Mike Witt | Jim Clancy | Jim Clancy | Mike Witt | | 263 | 224 | 39 |
| 1982-06-16 | vs TOR | 62 | W 7-1 | 36-26 | 2 | 20,970 | Steve Renko | Dave Stieb | Steve Renko | Dave Stieb | | 270 | 225 | 45 |
| 1982-06-17 | vs TOR | 63 | W 10-8 | 37-26 | 1 | 21,195 | Bruce Kison | Luis Leal | Bruce Kison | Luis Leal | Angel Moreno | 280 | 233 | 47 |
| 1982-06-18 | vs CHA | 64 | W 7-2 | 38-26 | 1 | 48,222 | Ken Forsch | Dennis Lamp | Angel Moreno | Dennis Lamp | | 287 | 235 | 52 |
| 1982-06-19 | vs CHA | 65 | L 6-7 | 38-27 | 1 | 30,666 | Geoff Zahn | Richard Dotson | Richard Dotson | Geoff Zahn | Kevin Hickey | 293 | 242 | 51 |
| 1982-06-20 | vs CHA | 66 | W 3-1 | 39-27 | 1 | 49,567 | Mike Witt | LaMarr Hoyt | Mike Witt | LaMarr Hoyt | | 296 | 243 | 53 |
| 1982-06-21 | vs TEX | 67 | W 10-2 | 40-27 | 1 | 23,475 | Steve Renko | Charlie Hough | Steve Renko | Charlie Hough | | 306 | 245 | 61 |
| 1982-06-22 | vs TEX | 68 | L 0-4 | 40-28 | 1 | 25,634 | Bruce Kison | Rick Honeycutt | Rick Honeycutt | Bruce Kison | | 306 | 249 | 57 |
| 1982-06-23 | vs TEX | 69 | W 5-3 | 41-28 | 1 | 25,207 | Ken Forsch | Doc Medich | Ken Forsch | Doc Medich | Doug Corbett | 311 | 252 | 59 |
| 1982-06-24 | vs KCA | 70 | W 7-2 | 42-28 | 1 | 29,250 | Geoff Zahn | Keith Creel | Geoff Zahn | Keith Creel | | 318 | 254 | 64 |
| 1982-06-25 | vs KCA | 71 | L 6-8 | 42-29 | 1 | 34,301 | Mike Witt | Paul Splittorff | Dan Quisenberry | Angel Moreno | | 324 | 262 | 62 |
| 1982-06-26 | vs KCA | 72 | W 6-5 | 43-29 | 1 | 56,794 | Steve Renko | Vida Blue | Ken Forsch | Dan Quisenberry | | 330 | 267 | 63 |
| 1982-06-27 | vs KCA | 73 | W 9-1 | 44-29 | 1 | 36,572 | Dave Goltz | Buddy Black | Dave Goltz | Buddy Black | | 339 | 268 | 71 |
| 1982-06-29 | @ TEX | 74 | W 2-1 | 45-29 | 1 | 15,749 | Geoff Zahn | Doc Medich | Geoff Zahn | Doc Medich | Doug Corbett | 341 | 269 | 72 |
| 1982-06-30 | @ TEX | 75 | L 3-5 | 45-30 | 1 | 14,133 | Ken Forsch | Jon Matlack | Dave J. Schmidt | Don Aase | | 344 | 274 | 70 |
| 1982-07-01 | @ TEX | 76 | L 2-7 | 45-31 | 1 | 15,963 | Mike Witt | Frank Tanana | Frank Tanana | Mike Witt | | 346 | 281 | 65 |
| 1982-07-02 | @ KCA | 77 | L 2-7 | 45-32 | 1 | 29,609 | Steve Renko | Vida Blue | Vida Blue | Steve Renko | Mike Armstrong | 348 | 288 | 60 |
| 1982-07-03 | @ KCA | 78 | L 2-6 | 45-33 | 1 | 41,380 | Dave Goltz | Larry Gura | Larry Gura | Dave Goltz | Dan Quisenberry | 350 | 294 | 56 |
| 1982-07-04 | @ KCA | 79 | L 1-6 | 45-34 | 2 | 33,360 | Geoff Zahn | Buddy Black | Buddy Black | Geoff Zahn | | 351 | 300 | 51 |
| 1982-07-05 | vs BAL | 80 | L 5-8 | 45-35 | 2 | 27,571 | Ken Forsch | Scott McGregor | Scott McGregor | Ken Forsch | Tippy Martinez | 356 | 308 | 48 |
| 1982-07-06 | vs BAL | 81 | L 2-3 | 45-36 | 2 | 24,035 | Steve Renko | Dennis Martinez | Dennis Martinez | Doug Corbett | Tippy Martinez | 358 | 311 | 47 |
| 1982-07-07 | vs CLE | 82 | L 6-8 | 45-37 | 2 | 25,288 | Mike Witt | Rick Waits | Rick Waits | Mike Witt | Dan Spillner | 364 | 319 | 45 |
| 1982-07-08 | vs CLE | 83 | W 5-1 | 46-37 | 2 | 23,374 | Dave Goltz | Lary Sorensen | Dave Goltz | Lary Sorensen | Doug Corbett | 369 | 320 | 49 |
| 1982-07-09 | vs NYA | 84 | W 4-1 | 47-37 | 2 | 41,111 | Geoff Zahn | Tommy John | Geoff Zahn | Tommy John | | 373 | 321 | 52 |
| 1982-07-10 | vs NYA | 85 | W 12-6 | 48-37 | 2 | 53,851 | Ken Forsch | Ron Guidry | Ken Forsch | Ron Guidry | Andy Hassler | 385 | 327 | 58 |
| 1982-07-11 | vs NYA | 86 | W 2-1 | 49-37 | 1 | 44,834 | Steve Renko | Shane Rawley | Andy Hassler | Rich Gossage | Don Aase | 387 | 328 | 59 |
| 1982-07-15 | @ CLE | 87 | W 8-2 | 50-37 | 1 | 10,375 | Dave Goltz | Rick Waits | Dave Goltz | Rick Waits | | 395 | 330 | 65 |
| 1982-07-16 | @ CLE | 88 | W 15-0 | 51-37 | 1 | 18,472 | Ken Forsch | John Denny | Ken Forsch | John Denny | | 410 | 330 | 80 |
| 1982-07-17 | @ CLE | 89 | L 4-10 | 51-38 | 1 | 19,831 | Geoff Zahn | Rick Sutcliffe | Ed Glynn | Doug Corbett | | 414 | 340 | 74 |
| 1982-07-18 | @ CLE | 90 | L 4-5 | 51-39 | 1 | 16,416 | Mike Witt | Len Barker | Ed Glynn | Doug Corbett | | 418 | 345 | 73 |
| 1982-07-19 | @ BAL | 91 | W 6-5 | 52-39 | 1 | 23,146 | Steve Renko | Scott McGregor | Steve Renko | Scott McGregor | Bruce Kison | 424 | 350 | 74 |
| 1982-07-20 | @ BAL | 92 | W 7-4 | 53-39 | 1 | 16,601 | Dave Goltz | Dennis Martinez | Dave Goltz | Dennis Martinez | Andy Hassler | 431 | 354 | 77 |
| 1982-07-21 | @ BAL | 93 | L 7-8 | 53-40 | 1 | 20,570 | Ken Forsch | Mike Flanagan | Sammy Stewart | Andy Hassler | Tippy Martinez | 438 | 362 | 76 |
| 1982-07-23 | @ NYA | 94 | L 3-6 | 53-41 | 1 | 50,314 | Geoff Zahn | Shane Rawley | Shane Rawley | Geoff Zahn | Dave Righetti | 441 | 368 | 73 |
| 1982-07-24 | @ NYA | 95 | L 5-6 | 53-42 | 1 | 47,917 | Steve Renko | Ron Guidry | Rudy May | Bruce Kison | | 446 | 374 | 72 |
| 1982-07-25 | @ NYA | 96 | W 6-4 | 54-42 | 1 | 51,561 | Dave Goltz | Tommy John | Mickey Mahler | Tommy John | | 452 | 378 | 74 |
| 1982-07-26 | vs OAK | 97 | L 8-11 | 54-43 | 1 | 47,260 | Ken Forsch | Steve McCatty | Dave Beard | Luis Sanchez | | 460 | 389 | 71 |
| 1982-07-27 | vs OAK | 98 | W 8-7 | 55-43 | 1 | 32,609 | Geoff Zahn | Mike Norris | Dave Goltz | Bob Owchinko | | 468 | 396 | 72 |
| 1982-07-28 | vs OAK | 99 | W 13-1 | 56-43 | 1 | 32,689 | Mike Witt | Matt Keough | Mike Witt | Matt Keough | | 481 | 397 | 84 |
| 1982-07-29 | vs SEA | 100 | W 3-1 | 57-43 | 1 | 26,512 | Steve Renko | Mike Moore | Steve Renko | Mike Moore | Luis Sanchez | 484 | 398 | 86 |
| 1982-07-30 | vs SEA | 101 | W 2-0 | 58-43 | 1 | 31,581 | Ken Forsch | Jim Beattie | Ken Forsch | Jim Beattie | | 486 | 398 | 88 |
| 1982-07-31 | vs SEA | 102 | L 3-9 | 58-44 | 1 | 41,770 | Dave Goltz | Floyd Bannister | Floyd Bannister | Dave Goltz | | 489 | 407 | 82 |
| 1982-08-01 | vs SEA | 103 | W 9-4 | 59-44 | 1 | 27,025 | Geoff Zahn | Rich Bordi | Geoff Zahn | Rich Bordi | | 498 | 411 | 87 |
| 1982-08-02 | vs MIN | 104 | L 7-9 | 59-45 | 2 | 25,097 | Mike Witt | Bobby Castillo | Jeff Little | Luis Sanchez | Ron Davis | 505 | 420 | 85 |
| 1982-08-03 | vs MIN | 105 | L 4-5 | 59-46 | 2 | 26,184 | Steve Renko | Brad Havens | Brad Havens | Steve Renko | Terry Felton | 509 | 425 | 84 |
| 1982-08-04 | vs MIN | 106 | W 8-6 | 60-46 | 2 | 28,054 | Ken Forsch | Albert Williams | Dave Goltz | Terry Felton | | 517 | 431 | 86 |
| 1982-08-05 | vs MIN | 107 | L 6-8 | 60-47 | 2 | 32,711 | Luis Tiant | Jack O'Connor | Jack O'Connor | Luis Tiant | Ron Davis | 523 | 439 | 84 |
| 1982-08-06 | @ SEA | 108 | W 11-9 | 61-47 | 2 | 20,074 | Geoff Zahn | Floyd Bannister | Luis Sanchez | Floyd Bannister | Andy Hassler | 534 | 448 | 86 |
| 1982-08-07 | @ SEA | 109 | W 3-1 | 62-47 | 1 | 40,775 | Mike Witt | Gaylord Perry | Mike Witt | Gaylord Perry | | 537 | 449 | 88 |
| 1982-08-08 | @ SEA | 110 | W 9-5 | 63-47 | 1 | 13,281 | Steve Renko | Mike Moore | Steve Renko | Mike Moore | Andy Hassler | 546 | 454 | 92 |
| 1982-08-10 | @ MIN | 111 | L 2-5 | 63-48 | 2 | 17,189 | Ken Forsch | Albert Williams | Pete Redfern | Ken Forsch | Ron Davis | 548 | 459 | 89 |
| 1982-08-11 | @ MIN | 112 | W 6-3 | 64-48 | 2 | 14,115 | Geoff Zahn | Jack O'Connor | Geoff Zahn | Terry Felton | Dave Goltz | 554 | 462 | 92 |
| 1982-08-12 | @ MIN | 113 | W 3-1 | 65-48 | 1 | 11,088 | Luis Tiant | Frank Viola | Luis Tiant | Frank Viola | Luis Sanchez | 557 | 463 | 94 |
| 1982-08-13 | @ OAK | 114 | W 9-0 | 66-48 | 1 | 28,330 | Mike Witt | Mike Norris | Mike Witt | Mike Norris | | 566 | 463 | 103 |
| 1982-08-14 | @ OAK | 115 | L 1-10 | 66-49 | 1 | 32,139 | Steve Renko | Matt Keough | Matt Keough | Steve Renko | Tom Underwood | 567 | 473 | 94 |
| 1982-08-15 | @ OAK | 116 | L 2-3 | 66-50 | 2 | 40,634 | Ken Forsch | Brian Kingman | Tom Underwood | Dave Goltz | | 569 | 476 | 93 |
| 1982-08-16 | @ OAK | 117 | W 8-4 | 67-50 | 1 | 37,388 | Geoff Zahn | Steve McCatty | Geoff Zahn | Steve McCatty | Dave Goltz | 577 | 480 | 97 |
| 1982-08-17 | vs BOS | 118 | W 10-2 | 68-50 | 1 | 38,051 | Luis Tiant | Bob Ojeda | Luis Tiant | Bob Ojeda | | 587 | 482 | 105 |
| 1982-08-18 | vs BOS | 119 | L 1-4 | 68-51 | 1 | 38,432 | Mike Witt | John Tudor | John Tudor | Mike Witt | Bob Stanley | 588 | 486 | 102 |
| 1982-08-19 | vs BOS | 120 | W 8-5 | 69-51 | 1 | 38,693 | Steve Renko | Dennis Eckersley | Bruce Kison | Mark Clear | | 596 | 491 | 105 |
| 1982-08-20 | vs DET | 121 | L 6-8 | 69-52 | 2 | 36,316 | Ken Forsch | Jerry Ujdur | Jerry Ujdur | Ken Forsch | Dave Tobik | 602 | 499 | 103 |
| 1982-08-21 | vs DET | 122 | W 13-1 | 70-52 | 2 | 44,194 | Geoff Zahn | Jack Morris | Geoff Zahn | Jack Morris | | 615 | 500 | 115 |
| 1982-08-22 | vs DET | 123 | W 6-5 | 71-52 | 1 | 33,136 | Luis Tiant | Milt Wilcox | Luis Sanchez | Dave Rucker | | 621 | 505 | 116 |
| 1982-08-23 | vs MIL | 124 | W 5-3 | 72-52 | 1 | 35,197 | Mike Witt | Bob McClure | Mike Witt | Bob McClure | | 626 | 508 | 118 |
| 1982-08-24 | vs MIL | 125 | L 3-7 | 72-53 | 1 | 41,921 | Steve Renko | Pete Vuckovich | Pete Vuckovich | Steve Renko | | 629 | 515 | 114 |
| 1982-08-26 | @ BOS | 126 | W 10-1 | 73-54 | 2 | 19,902 | Ken Forsch | Mike Torrez | Ken Forsch | Mike Torrez | | 639 | 516 | 123 |
| 1982-08-26 | @ BOS | 127 | L 3-4 | 73-54 | 2 | 31,406 | Geoff Zahn | Chuck Rainey | Bob Stanley | Geoff Zahn | | 642 | 520 | 122 |
| 1982-08-27 | @ BOS | 128 | W 7-6 | 74-54 | 2 | 32,755 | Rick Steirer | Brian Denman | Rick Steirer | Brian Denman | Doug Corbett | 649 | 526 | 123 |
| 1982-08-28 | @ BOS | 129 | L 6-7 | 74-55 | 2 | 34,772 | Mike Witt | John Tudor | Mark Clear | Bruce Kison | | 655 | 533 | 122 |
| 1982-08-29 | @ BOS | 130 | L 3-9 | 74-56 | 2 | 32,356 | Steve Renko | Dennis Eckersley | Dennis Eckersley | Steve Renko | Bob Stanley | 658 | 542 | 116 |
| 1982-08-31 | @ DET | 131 | W 11-0 | 75-56 | 2 | 15,187 | Geoff Zahn | Jack Morris | Geoff Zahn | Jack Morris | | 669 | 542 | 127 |
| 1982-09-01 | @ DET | 132 | L 3-5 | 75-57 | 2 | 11,430 | Ken Forsch | Milt Wilcox | Milt Wilcox | Ken Forsch | Pat Underwood | 672 | 547 | 125 |
| 1982-09-02 | @ DET | 133 | L 3-6 | 75-58 | 2 | 12,547 | Mike Witt | Juan Berenguer | Aurelio Lopez | Mike Witt | | 675 | 553 | 122 |
| 1982-09-03 | @ MIL | 134 | W 5-2 | 76-58 | 2 | 35,217 | Tommy John | Bob McClure | Tommy John | Bob McClure | | 680 | 555 | 125 |
| 1982-09-04 | @ MIL | 135 | L 2-8 | 76-59 | 2 | 30,391 | Luis Tiant | Pete Vuckovich | Pete Vuckovich | Luis Tiant | | 682 | 563 | 119 |
| 1982-09-05 | @ MIL | 136 | L 5-8 | 76-60 | 2 | 36,258 | Geoff Zahn | Mike Caldwell | Mike Caldwell | Geoff Zahn | Pete Ladd | 687 | 571 | 116 |
| 1982-09-06 | vs CHA | 137 | W 8-6 | 77-60 | 2 | 42,804 | Ken Forsch | Jerry Koosman | Steve Renko | Jim Kern | | 695 | 577 | 118 |
| 1982-09-07 | vs CHA | 138 | L 4-7 | 77-61 | 2 | 30,032 | Tommy John | Britt Burns | LaMarr Hoyt | Tommy John | Salome Barojas | 699 | 584 | 115 |
| 1982-09-08 | vs CHA | 139 | L 3-5 | 77-62 | 2 | 24,930 | Mike Witt | Richard Dotson | Richard Dotson | John Curtis | Salome Barojas | 702 | 589 | 113 |
| 1982-09-10 | vs TOR | 140 | W 6-2 | 78-62 | 2 | 25,012 | Geoff Zahn | Luis Leal | Geoff Zahn | Luis Leal | | 708 | 591 | 117 |
| 1982-09-11 | vs TOR | 141 | W 4-1 | 79-62 | 2 | 43,819 | Ken Forsch | Dave Stieb | Ken Forsch | Dave Stieb | | 712 | 592 | 120 |
| 1982-09-12 | vs TOR | 142 | W 3-2 | 80-62 | 2 | 25,394 | Tommy John | Jim Clancy | Tommy John | Jim Clancy | John Curtis | 715 | 594 | 121 |
| 1982-09-13 | @ CHA | 143 | W 6-4 | 81-62 | 2 | 13,474 | Mike Witt | Richard Dotson | Luis Sanchez | Kevin Hickey | | 721 | 598 | 123 |
| 1982-09-14 | @ CHA | 144 | W 7-0 | 82-62 | 2 | 13,798 | Bruce Kison | Dennis Lamp | Bruce Kison | Dennis Lamp | | 728 | 598 | 130 |
| 1982-09-15 | @ CHA | 145 | L 3-8 | 82-63 | 2 | 13,744 | Geoff Zahn | Jerry Koosman | Jerry Koosman | Geoff Zahn | | 731 | 606 | 125 |
| 1982-09-16 | @ TOR | 146 | L 1-2 | 82-64 | 2 | 15,693 | Ken Forsch | Dave Stieb | Roy Lee Jackson | Luis Sanchez | | 732 | 608 | 124 |
| 1982-09-17 | @ TOR | 147 | L 2-6 | 82-65 | 2 | 15,605 | Tommy John | Jim Clancy | Jim Clancy | Tommy John | Dale Murray | 734 | 614 | 120 |
| 1982-09-18 | @ TOR | 148 | W 8-6 | 83-65 | 2 | 20,533 | Mike Witt | Jim Gott | Luis Sanchez | Dale Murray | | 742 | 620 | 122 |
| 1982-09-19 | @ TOR | 149 | W 5-1 | 84-65 | 2 | 22,025 | Bruce Kison | Mark Eichhorn | Bruce Kison | Mark Eichhorn | | 747 | 621 | 126 |
| 1982-09-20 | vs KCA | 150 | W 3-2 | 85-65 | 1 | 42,322 | Geoff Zahn | Larry Gura | Geoff Zahn | Larry Gura | Luis Sanchez | 750 | 623 | 127 |
| 1982-09-21 | vs KCA | 151 | W 2-1 | 86-65 | 1 | 52,415 | Ken Forsch | Dennis Leonard | Ken Forsch | Dan Quisenberry | | 752 | 624 | 128 |
| 1982-09-22 | vs KCA | 152 | W 8-5 | 87-65 | 1 | 51,273 | Tommy John | Vida Blue | Tommy John | Vida Blue | Dave Goltz | 760 | 629 | 131 |
| 1982-09-23 | @ TEX | 153 | L 4-5 | 87-66 | 1 | 7,138 | Steve Renko | Mike Mason | Danny Darwin | Mike Witt | | 764 | 634 | 130 |
| 1982-09-24 | @ TEX | 154 | W 10-1 | 88-66 | 1 | 9,330 | Bruce Kison | Rick Honeycutt | Bruce Kison | Rick Honeycutt | | 774 | 635 | 139 |
| 1982-09-25 | @ TEX | 155 | W 6-5 | 89-66 | 1 | 13,210 | Geoff Zahn | John Butcher | Dave Goltz | Danny Darwin | | 780 | 640 | 140 |
| 1982-09-26 | @ TEX | 156 | L 5-7 | 89-67 | 1 | 29,036 | Ken Forsch | Charlie Hough | Charlie Hough | Ken Forsch | | 785 | 647 | 138 |
| 1982-09-27 | @ KCA | 157 | W 3-2 | 90-67 | 1 | 38,278 | Tommy John | Vida Blue | Tommy John | Vida Blue | Luis Sanchez | 788 | 649 | 139 |
| 1982-09-28 | @ KCA | 158 | L 4-5 | 90-68 | 1 | 30,454 | Mike Witt | Larry Gura | Mike Armstrong | Dave Goltz | Dan Quisenberry | 792 | 654 | 138 |
| 1982-09-29 | @ KCA | 159 | L 5-6 | 90-69 | 1 | 26,502 | Bruce Kison | Dennis Leonard | Bob Tufts | Luis Sanchez | Dan Quisenberry | 797 | 660 | 137 |
| 1982-10-01 | vs TEX | 160 | W 4-0 | 91-69 | 1 | 39,558 | Geoff Zahn | John Butcher | Geoff Zahn | John Butcher | | 801 | 660 | 141 |
| 1982-10-02 | vs TEX | 161 | W 6-4 | 92-69 | 1 | 33,405 | Ken Forsch | Charlie Hough | Dave Goltz | Charlie Hough | Luis Sanchez | 807 | 664 | 143 |
| 1982-10-03 | vs TEX | 162 | W 7-6 | 93-69 | 1 | 62,020 | Tommy John | Mike Smithson | Mickey Mahler | Danny Darwin | | 814 | 670 | 144 |