| 1982-04-06 | @ MIN | 1 | W 11-7 | 1-0 | 2 | 52,279 | Floyd Bannister | Pete Redfern | Floyd Bannister | Pete Redfern | Mike Stanton | 11 | 7 | 4 |
| 1982-04-07 | @ MIN | 2 | L 5-7 | 1-1 | 3 | 5,213 | Jim Beattie | Roger Erickson | Roger Erickson | Jim Beattie | Doug Corbett | 16 | 14 | 2 |
| 1982-04-08 | @ MIN | 3 | L 1-4 | 1-2 | 4 | 10,412 | Gene Nelson | Brad Havens | Brad Havens | Gene Nelson | Doug Corbett | 17 | 18 | -1 |
| 1982-04-09 | @ OAK | 4 | L 3-5 | 1-3 | 5 | 28,139 | Gaylord Perry | Steve McCatty | Steve McCatty | Gaylord Perry | Bob Owchinko | 20 | 23 | -3 |
| 1982-04-11 | @ OAK | 5 | W 6-3 | 2-4 | 7 | 0 | Floyd Bannister | Mike Norris | Bill Caudill | Bo McLaughlin | | 26 | 26 | 0 |
| 1982-04-11 | @ OAK | 6 | L 1-3 | 2-4 | 7 | 19,003 | Mike Moore | Rick Langford | Rick Langford | Mike Moore | | 27 | 29 | -2 |
| 1982-04-13 | @ CAL | 7 | L 3-4 | 2-5 | 6 | 33,574 | Jim Beattie | Geoff Zahn | Luis Sanchez | Gene Nelson | | 30 | 33 | -3 |
| 1982-04-14 | @ CAL | 8 | L 1-2 | 2-6 | 7 | 23,905 | Gene Nelson | Mike Witt | Steve Renko | Ed Vande Berg | | 31 | 35 | -4 |
| 1982-04-15 | @ CAL | 9 | L 2-3 | 2-7 | 7 | 22,410 | Gaylord Perry | Angel Moreno | Angel Moreno | Gaylord Perry | | 33 | 38 | -5 |
| 1982-04-16 | vs OAK | 10 | W 5-0 | 3-7 | 7 | 23,856 | Floyd Bannister | Mike Norris | Floyd Bannister | Mike Norris | | 38 | 38 | 0 |
| 1982-04-17 | vs OAK | 11 | L 3-10 | 3-8 | 7 | 29,379 | Mike Moore | Matt Keough | Matt Keough | Mike Moore | | 41 | 48 | -7 |
| 1982-04-18 | vs OAK | 12 | W 4-3 | 4-8 | 7 | 8,960 | Ed Nunez | Steve McCatty | Ed Vande Berg | Tom Underwood | | 45 | 51 | -6 |
| 1982-04-19 | vs CAL | 13 | L 1-3 | 4-9 | 7 | 5,494 | Gene Nelson | Mike Witt | Mike Witt | Gene Nelson | Don Aase | 46 | 54 | -8 |
| 1982-04-20 | vs CAL | 14 | W 6-4 | 5-9 | 7 | 7,419 | Gaylord Perry | Angel Moreno | Gaylord Perry | Angel Moreno | Mike Stanton | 52 | 58 | -6 |
| 1982-04-21 | vs CAL | 15 | W 5-3 | 6-9 | 7 | 4,961 | Floyd Bannister | Bruce Kison | Floyd Bannister | Steve Renko | Bill Caudill | 57 | 61 | -4 |
| 1982-04-22 | vs MIN | 16 | W 8-4 | 7-9 | 6 | 4,601 | Mike Moore | Pete Redfern | Mike Moore | Pete Redfern | Mike Stanton | 65 | 65 | 0 |
| 1982-04-23 | vs MIN | 17 | L 4-12 | 7-10 | 7 | 5,665 | Ed Nunez | Roger Erickson | Roger Erickson | Ed Nunez | | 69 | 77 | -8 |
| 1982-04-24 | vs MIN | 18 | W 3-2 | 8-10 | 6 | 18,651 | Gene Nelson | Brad Havens | Ed Vande Berg | Ron Davis | Bill Caudill | 72 | 79 | -7 |
| 1982-04-25 | vs MIN | 19 | W 5-4 | 9-10 | 4 | 7,203 | Gaylord Perry | Albert Williams | Bill Caudill | Terry Felton | | 77 | 83 | -6 |
| 1982-04-27 | @ CLE | 20 | W 7-4 | 10-10 | 4 | 3,275 | Floyd Bannister | Rick Waits | Bill Caudill | Dan Spillner | Ed Vande Berg | 84 | 87 | -3 |
| 1982-04-28 | @ CLE | 21 | L 1-6 | 10-11 | 4 | 3,889 | Mike Moore | Len Barker | Len Barker | Mike Moore | | 85 | 93 | -8 |
| 1982-04-29 | @ CLE | 22 | L 1-5 | 10-12 | 5 | 3,984 | Gene Nelson | Lary Sorensen | Lary Sorensen | Gene Nelson | | 86 | 98 | -12 |
| 1982-04-30 | @ NYA | 23 | W 6-3 | 11-12 | 5 | 20,121 | Gaylord Perry | Doyle Alexander | Gaylord Perry | Rich Gossage | Bill Caudill | 92 | 101 | -9 |
| 1982-05-01 | @ NYA | 24 | L 1-5 | 11-13 | 5 | 20,118 | Jim Beattie | Mike Morgan | George Frazier | Jim Beattie | | 93 | 106 | -13 |
| 1982-05-02 | @ NYA | 25 | L 2-4 | 11-14 | 5 | 35,029 | Floyd Bannister | Ron Guidry | Ron Guidry | Floyd Bannister | Rich Gossage | 95 | 110 | -15 |
| 1982-05-03 | @ BAL | 26 | L 0-6 | 11-15 | 5 | 9,241 | Mike Moore | Mike Flanagan | Mike Flanagan | Mike Moore | | 95 | 116 | -21 |
| 1982-05-04 | @ BAL | 27 | W 4-3 | 12-15 | 5 | 8,040 | Gene Nelson | Dennis Martinez | Gene Nelson | Sammy Stewart | Ed Vande Berg | 99 | 119 | -20 |
| 1982-05-06 | vs NYA | 28 | W 7-3 | 13-15 | 5 | 27,369 | Gaylord Perry | Doyle Alexander | Gaylord Perry | Doyle Alexander | | 106 | 122 | -16 |
| 1982-05-07 | vs NYA | 29 | W 5-2 | 14-15 | 5 | 11,721 | Floyd Bannister | Mike Morgan | Floyd Bannister | Mike Morgan | Bill Caudill | 111 | 124 | -13 |
| 1982-05-08 | vs NYA | 30 | L 4-9 | 14-16 | 5 | 36,716 | Jim Beattie | Ron Guidry | Ron Guidry | Jim Beattie | Rich Gossage | 115 | 133 | -18 |
| 1982-05-09 | vs NYA | 31 | L 0-3 | 14-17 | 5 | 7,577 | Gene Nelson | Tommy John | Tommy John | Gene Nelson | Rich Gossage | 115 | 136 | -21 |
| 1982-05-10 | vs CLE | 32 | W 6-4 | 15-17 | 5 | 4,625 | Mike Moore | John Bohnet | Ed Vande Berg | Rick Sutcliffe | Bill Caudill | 121 | 140 | -19 |
| 1982-05-11 | vs CLE | 33 | L 4-5 | 15-18 | 5 | 14,454 | Gaylord Perry | John Denny | Ed Whitson | Bill Caudill | | 125 | 145 | -20 |
| 1982-05-12 | vs CLE | 34 | L 5-8 | 15-19 | 5 | 4,691 | Floyd Bannister | Rick Waits | Rick Sutcliffe | Floyd Bannister | | 130 | 153 | -23 |
| 1982-05-13 | vs BAL | 35 | L 1-3 | 15-20 | 5 | 5,304 | Jim Beattie | Dennis Martinez | Dennis Martinez | Jim Beattie | | 131 | 156 | -25 |
| 1982-05-14 | vs BAL | 36 | L 4-11 | 15-21 | 5 | 6,489 | Gene Nelson | Sammy Stewart | Sammy Stewart | Gene Nelson | Jim Palmer | 135 | 167 | -32 |
| 1982-05-15 | vs BAL | 37 | W 3-2 | 16-21 | 5 | 23,682 | Mike Moore | Scott McGregor | Bill Caudill | Scott McGregor | | 138 | 169 | -31 |
| 1982-05-16 | vs BAL | 38 | L 4-5 | 16-22 | 5 | 6,504 | Gaylord Perry | Mike Flanagan | Tippy Martinez | Gaylord Perry | Tim Stoddard | 142 | 174 | -32 |
| 1982-05-18 | @ BOS | 39 | W 3-0 | 17-22 | 5 | 16,436 | Floyd Bannister | Dennis Eckersley | Floyd Bannister | Dennis Eckersley | | 145 | 174 | -29 |
| 1982-05-19 | @ BOS | 40 | L 5-6 | 17-23 | 5 | 12,927 | Larry Andersen | Chuck Rainey | Mark Clear | Bill Caudill | | 150 | 180 | -30 |
| 1982-05-20 | @ BOS | 41 | L 2-11 | 17-24 | 5 | 14,587 | Mike Moore | John Tudor | John Tudor | Mike Moore | | 152 | 191 | -39 |
| 1982-05-21 | @ MIL | 42 | L 1-4 | 17-25 | 5 | 11,545 | Gaylord Perry | Bob McClure | Bob McClure | Gaylord Perry | Rollie Fingers | 153 | 195 | -42 |
| 1982-05-22 | @ MIL | 43 | W 7-1 | 18-25 | 5 | 25,630 | Gene Nelson | Randy Lerch | Gene Nelson | Randy Lerch | | 160 | 196 | -36 |
| 1982-05-23 | @ MIL | 44 | W 6-5 | 19-25 | 5 | 17,387 | Floyd Bannister | Mike Caldwell | Bill Caudill | Rollie Fingers | | 166 | 201 | -35 |
| 1982-05-25 | vs DET | 45 | W 7-6 | 20-25 | 5 | 6,406 | Jim Beattie | Milt Wilcox | Bill Caudill | Elias Sosa | | 173 | 207 | -34 |
| 1982-05-26 | vs DET | 46 | W 4-2 | 21-25 | 5 | 7,775 | Gaylord Perry | Jack Morris | Gaylord Perry | Jack Morris | Bill Caudill | 177 | 209 | -32 |
| 1982-05-27 | vs BOS | 47 | W 10-6 | 22-25 | 5 | 6,186 | Gene Nelson | Mike Torrez | Gene Nelson | Mike Torrez | | 187 | 215 | -28 |
| 1982-05-28 | vs BOS | 48 | L 2-3 | 22-26 | 5 | 10,634 | Floyd Bannister | Dennis Eckersley | Dennis Eckersley | Floyd Bannister | Mark Clear | 189 | 218 | -29 |
| 1982-05-29 | vs BOS | 49 | W 4-2 | 23-26 | 4 | 25,756 | Mike Moore | Bruce Hurst | Mike Moore | Bruce Hurst | Bill Caudill | 193 | 220 | -27 |
| 1982-05-30 | vs BOS | 50 | W 2-1 | 24-26 | 4 | 9,857 | Jim Beattie | John Tudor | Jim Beattie | John Tudor | | 195 | 221 | -26 |
| 1982-05-31 | vs MIL | 51 | W 5-4 | 25-26 | 4 | 8,424 | Gaylord Perry | Bob McClure | Mike Stanton | Jerry Augustine | | 200 | 225 | -25 |
| 1982-06-01 | vs MIL | 52 | L 1-2 | 25-27 | 4 | 5,321 | Gene Nelson | Pete Vuckovich | Pete Vuckovich | Gene Nelson | Rollie Fingers | 201 | 227 | -26 |
| 1982-06-02 | vs MIL | 53 | L 2-5 | 25-28 | 5 | 8,937 | Floyd Bannister | Mike Caldwell | Mike Caldwell | Floyd Bannister | | 203 | 232 | -29 |
| 1982-06-04 | @ DET | 54 | W 4-0 | 26-28 | 4 | 32,404 | Jim Beattie | Jack Morris | Jim Beattie | Jack Morris | | 207 | 232 | -25 |
| 1982-06-06 | @ DET | 55 | L 2-10 | 26-29 | 4 | 18,378 | Gaylord Perry | Dan Petry | Dan Petry | Gaylord Perry | | 209 | 242 | -33 |
| 1982-06-07 | @ TEX | 56 | W 6-0 | 27-29 | 4 | 8,484 | Gene Nelson | Jon Matlack | Gene Nelson | Jon Matlack | | 215 | 242 | -27 |
| 1982-06-08 | @ TEX | 57 | W 2-1 | 28-29 | 4 | 8,971 | Floyd Bannister | Frank Tanana | Bill Caudill | Paul Mirabella | Larry Andersen | 217 | 243 | -26 |
| 1982-06-09 | @ TEX | 58 | W 4-3 | 29-29 | 4 | 8,459 | Jim Beattie | Charlie Hough | Ed Vande Berg | Steve Comer | | 221 | 246 | -25 |
| 1982-06-11 | @ KCA | 59 | L 2-3 | 29-30 | 4 | 34,824 | Gaylord Perry | Vida Blue | Dan Quisenberry | Ed Vande Berg | | 223 | 249 | -26 |
| 1982-06-12 | @ KCA | 60 | W 3-2 | 30-30 | 4 | 32,098 | Gene Nelson | Keith Creel | Gene Nelson | Keith Creel | Bill Caudill | 226 | 251 | -25 |
| 1982-06-13 | @ KCA | 61 | W 7-1 | 31-30 | 4 | 30,683 | Floyd Bannister | Larry Gura | Floyd Bannister | Larry Gura | | 233 | 252 | -19 |
| 1982-06-14 | vs TEX | 62 | W 4-0 | 32-30 | 4 | 10,795 | Jim Beattie | Jon Matlack | Jim Beattie | Jon Matlack | Mike Stanton | 237 | 252 | -15 |
| 1982-06-15 | vs TEX | 63 | L 2-5 | 32-31 | 4 | 9,900 | Mike Moore | Frank Tanana | Frank Tanana | Mike Moore | Steve Comer | 239 | 257 | -18 |
| 1982-06-16 | vs TEX | 64 | W 7-2 | 33-31 | 4 | 10,066 | Gaylord Perry | Charlie Hough | Gaylord Perry | Charlie Hough | Bill Caudill | 246 | 259 | -13 |
| 1982-06-17 | vs TEX | 65 | L 1-5 | 33-32 | 4 | 8,446 | Gene Nelson | Rick Honeycutt | Rick Honeycutt | Gene Nelson | | 247 | 264 | -17 |
| 1982-06-18 | vs KCA | 66 | L 1-4 | 33-33 | 4 | 13,057 | Floyd Bannister | Larry Gura | Larry Gura | Bill Caudill | Dan Quisenberry | 248 | 268 | -20 |
| 1982-06-19 | vs KCA | 67 | W 10-3 | 34-33 | 4 | 22,150 | Jim Beattie | Keith Creel | Jim Beattie | Keith Creel | | 258 | 271 | -13 |
| 1982-06-20 | vs KCA | 68 | L 5-7 | 34-34 | 4 | 17,468 | Gaylord Perry | Paul Splittorff | Paul Splittorff | Gaylord Perry | Dan Quisenberry | 263 | 278 | -15 |
| 1982-06-21 | vs TOR | 69 | W 5-4 | 35-34 | 4 | 7,486 | Mike Moore | Luis Leal | Mike Moore | Luis Leal | Bill Caudill | 268 | 282 | -14 |
| 1982-06-22 | vs TOR | 70 | W 6-5 | 36-34 | 4 | 7,933 | Gene Nelson | Jerry Garvin | Bryan Clark | Roy Lee Jackson | Bill Caudill | 274 | 287 | -13 |
| 1982-06-23 | vs TOR | 71 | L 3-5 | 36-35 | 4 | 9,007 | Floyd Bannister | Jim Clancy | Joey McLaughlin | Mike Stanton | | 277 | 292 | -15 |
| 1982-06-25 | vs CHA | 72 | W 1-0 | 37-35 | 4 | 28,815 | Jim Beattie | LaMarr Hoyt | Jim Beattie | LaMarr Hoyt | Bill Caudill | 278 | 292 | -14 |
| 1982-06-26 | vs CHA | 73 | L 3-13 | 37-36 | 4 | 30,950 | Gaylord Perry | Britt Burns | Britt Burns | Gaylord Perry | | 281 | 305 | -24 |
| 1982-06-27 | vs CHA | 74 | W 6-5 | 38-36 | 4 | 19,359 | Gene Nelson | Steve Trout | Gene Nelson | Steve Trout | Bill Caudill | 287 | 310 | -23 |
| 1982-06-29 | @ TOR | 75 | W 4-1 | 39-36 | 4 | 13,097 | Floyd Bannister | Jim Clancy | Floyd Bannister | Jim Clancy | Mike Stanton | 291 | 311 | -20 |
| 1982-06-30 | @ TOR | 76 | W 10-4 | 40-36 | 4 | 12,339 | Jim Beattie | Dave Stieb | Jim Beattie | Dave Stieb | | 301 | 315 | -14 |
| 1982-07-01 | @ TOR | 77 | W 4-3 | 41-36 | 4 | 21,004 | Gaylord Perry | Luis Leal | Gaylord Perry | Luis Leal | Bill Caudill | 305 | 318 | -13 |
| 1982-07-03 | @ CHA | 78 | L 6-7 | 41-37 | 4 | 20,198 | Mike Moore | Dennis Lamp | Jerry Koosman | Mike Stanton | | 311 | 325 | -14 |
| 1982-07-04 | @ CHA | 79 | W 3-1 | 42-37 | 4 | 21,762 | Floyd Bannister | Richard Dotson | Floyd Bannister | Richard Dotson | Bill Caudill | 314 | 326 | -12 |
| 1982-07-05 | vs NYA | 80 | W 5-4 | 43-37 | 3 | 36,471 | Jim Beattie | Shane Rawley | Ed Vande Berg | George Frazier | Bill Caudill | 319 | 330 | -11 |
| 1982-07-06 | vs NYA | 81 | L 7-8 | 43-38 | 4 | 26,002 | Gaylord Perry | Mike Morgan | Rudy May | Ed Vande Berg | | 326 | 338 | -12 |
| 1982-07-07 | vs BAL | 82 | W 8-7 | 44-38 | 4 | 12,405 | Gene Nelson | Storm Davis | Bill Caudill | Tim Stoddard | | 334 | 345 | -11 |
| 1982-07-08 | vs BAL | 83 | W 4-3 | 45-38 | 4 | 13,538 | Mike Moore | Mike Flanagan | Mike Moore | Mike Flanagan | Bill Caudill | 338 | 348 | -10 |
| 1982-07-09 | vs CLE | 84 | L 4-7 | 45-39 | 4 | 14,437 | Floyd Bannister | John Denny | John Denny | Floyd Bannister | Dan Spillner | 342 | 355 | -13 |
| 1982-07-10 | vs CLE | 85 | L 1-7 | 45-40 | 4 | 23,893 | Jim Beattie | Rick Sutcliffe | Rick Sutcliffe | Jim Beattie | | 343 | 362 | -19 |
| 1982-07-11 | vs CLE | 86 | L 3-4 | 45-41 | 4 | 11,645 | Gaylord Perry | Len Barker | Len Barker | Bill Caudill | | 346 | 366 | -20 |
| 1982-07-15 | @ BAL | 87 | L 2-3 | 45-42 | 4 | 14,592 | Jim Beattie | Scott McGregor | Scott McGregor | Jim Beattie | Sammy Stewart | 348 | 369 | -21 |
| 1982-07-16 | @ BAL | 88 | W 6-0 | 46-42 | 4 | 13,259 | Floyd Bannister | Dennis Martinez | Floyd Bannister | Dennis Martinez | | 354 | 369 | -15 |
| 1982-07-17 | @ BAL | 89 | L 4-8 | 46-43 | 4 | 21,082 | Gaylord Perry | Mike Flanagan | Storm Davis | Gaylord Perry | | 358 | 377 | -19 |
| 1982-07-18 | @ BAL | 90 | L 3-4 | 46-44 | 4 | 15,169 | Mike Moore | Jim Palmer | Sammy Stewart | Mike Moore | | 361 | 381 | -20 |
| 1982-07-19 | @ NYA | 91 | L 3-5 | 46-45 | 4 | 16,408 | Gene Nelson | Tommy John | Tommy John | Gene Nelson | Rich Gossage | 364 | 386 | -22 |
| 1982-07-20 | @ NYA | 92 | W 6-5 | 47-45 | 4 | 20,321 | Jim Beattie | Dave Righetti | Bill Caudill | Shane Rawley | | 370 | 391 | -21 |
| 1982-07-21 | @ NYA | 93 | W 6-5 | 48-45 | 4 | 23,531 | Floyd Bannister | Mike Morgan | Bill Caudill | George Frazier | | 376 | 396 | -20 |
| 1982-07-23 | @ CLE | 94 | L 3-4 | 48-46 | 4 | 13,352 | Gaylord Perry | Rick Sutcliffe | Dan Spillner | Ed Vande Berg | | 379 | 400 | -21 |
| 1982-07-24 | @ CLE | 95 | W 9-0 | 49-46 | 4 | 27,583 | Mike Moore | Len Barker | Mike Moore | Len Barker | | 388 | 400 | -12 |
| 1982-07-25 | @ CLE | 96 | L 3-5 | 49-47 | 4 | 14,500 | Jim Beattie | Lary Sorensen | Lary Sorensen | Jim Beattie | Dan Spillner | 391 | 405 | -14 |
| 1982-07-26 | vs MIN | 97 | L 4-10 | 49-48 | 4 | 12,021 | Floyd Bannister | Jack O'Connor | Jack O'Connor | Floyd Bannister | | 395 | 415 | -20 |
| 1982-07-27 | vs MIN | 98 | W 9-7 | 50-48 | 4 | 19,753 | Gene Nelson | Frank Viola | Bryan Clark | John Pacella | Bill Caudill | 404 | 422 | -18 |
| 1982-07-28 | vs MIN | 99 | W 6-2 | 51-48 | 3 | 14,703 | Gaylord Perry | Bobby Castillo | Gaylord Perry | Bobby Castillo | Mike Stanton | 410 | 424 | -14 |
| 1982-07-29 | @ CAL | 100 | L 1-3 | 51-49 | 3 | 26,512 | Mike Moore | Steve Renko | Steve Renko | Mike Moore | Luis Sanchez | 411 | 427 | -16 |
| 1982-07-30 | @ CAL | 101 | L 0-2 | 51-50 | 4 | 31,581 | Jim Beattie | Ken Forsch | Ken Forsch | Jim Beattie | | 411 | 429 | -18 |
| 1982-07-31 | @ CAL | 102 | W 9-3 | 52-50 | 4 | 41,770 | Floyd Bannister | Dave Goltz | Floyd Bannister | Dave Goltz | | 420 | 432 | -12 |
| 1982-08-01 | @ CAL | 103 | L 4-9 | 52-51 | 4 | 27,025 | Rich Bordi | Geoff Zahn | Geoff Zahn | Rich Bordi | | 424 | 441 | -17 |
| 1982-08-02 | @ OAK | 104 | L 5-6 | 52-52 | 4 | 18,751 | Gaylord Perry | Matt Keough | Matt Keough | Mike Stanton | | 429 | 447 | -18 |
| 1982-08-03 | @ OAK | 105 | W 3-2 | 53-52 | 4 | 10,318 | Mike Moore | Rick Langford | Mike Moore | Rick Langford | Bill Caudill | 432 | 449 | -17 |
| 1982-08-04 | @ OAK | 106 | W 5-2 | 54-53 | 4 | 0 | Jim Beattie | Brian Kingman | Jim Beattie | Brian Kingman | | 437 | 451 | -14 |
| 1982-08-04 | @ OAK | 107 | L 3-8 | 54-53 | 4 | 19,526 | Rich Bordi | Steve McCatty | Steve McCatty | Rich Bordi | Dave Beard | 440 | 459 | -19 |
| 1982-08-06 | vs CAL | 108 | L 9-11 | 54-54 | 4 | 20,074 | Floyd Bannister | Geoff Zahn | Luis Sanchez | Floyd Bannister | Andy Hassler | 449 | 470 | -21 |
| 1982-08-07 | vs CAL | 109 | L 1-3 | 54-55 | 4 | 40,775 | Gaylord Perry | Mike Witt | Mike Witt | Gaylord Perry | | 450 | 473 | -23 |
| 1982-08-08 | vs CAL | 110 | L 5-9 | 54-56 | 4 | 13,281 | Mike Moore | Steve Renko | Steve Renko | Mike Moore | Andy Hassler | 455 | 482 | -27 |
| 1982-08-09 | vs OAK | 111 | L 4-9 | 54-57 | 4 | 11,045 | Jim Beattie | Brian Kingman | Brian Kingman | Jim Beattie | | 459 | 491 | -32 |
| 1982-08-10 | vs OAK | 112 | W 4-2 | 55-57 | 4 | 11,509 | Bryan Clark | Steve McCatty | Ed Vande Berg | Steve McCatty | | 463 | 493 | -30 |
| 1982-08-11 | vs OAK | 113 | W 7-4 | 56-57 | 4 | 13,861 | Floyd Bannister | Rick Langford | Floyd Bannister | Rick Langford | Bill Caudill | 470 | 497 | -27 |
| 1982-08-13 | @ MIN | 114 | L 1-3 | 56-58 | 4 | 7,696 | Gaylord Perry | Bobby Castillo | Bobby Castillo | Gaylord Perry | | 471 | 500 | -29 |
| 1982-08-14 | @ MIN | 115 | W 3-1 | 57-58 | 4 | 7,756 | Mike Moore | Brad Havens | Mike Stanton | Brad Havens | Bill Caudill | 474 | 501 | -27 |
| 1982-08-15 | @ MIN | 116 | W 10-2 | 58-58 | 4 | 7,677 | Jim Beattie | Terry Felton | Jim Beattie | Terry Felton | | 484 | 503 | -19 |
| 1982-08-16 | @ DET | 117 | L 1-3 | 58-59 | 4 | 14,290 | Floyd Bannister | Jack Morris | Jack Morris | Floyd Bannister | | 485 | 506 | -21 |
| 1982-08-17 | @ DET | 118 | W 5-4 | 59-60 | 4 | 0 | Bryan Clark | Milt Wilcox | Bryan Clark | Milt Wilcox | Bill Caudill | 490 | 510 | -20 |
| 1982-08-17 | @ DET | 119 | L 2-3 | 59-60 | 4 | 17,697 | Bob Stoddard | Larry Pashnick | Larry Pashnick | Bob Stoddard | Dave Tobik | 492 | 513 | -21 |
| 1982-08-18 | @ DET | 120 | L 2-7 | 59-61 | 4 | 16,584 | Gaylord Perry | Dan Petry | Dan Petry | Gaylord Perry | Pat Underwood | 494 | 520 | -26 |
| 1982-08-20 | vs MIL | 121 | L 5-6 | 59-62 | 4 | 13,029 | Mike Moore | Mike Caldwell | Mike Caldwell | Mike Moore | Pete Ladd | 499 | 526 | -27 |
| 1982-08-21 | vs MIL | 122 | L 2-3 | 59-63 | 4 | 20,749 | Jim Beattie | Doc Medich | Doc Medich | Bryan Clark | Rollie Fingers | 501 | 529 | -28 |
| 1982-08-22 | vs MIL | 123 | L 5-8 | 59-64 | 4 | 9,290 | Floyd Bannister | Moose Haas | Jim Slaton | Floyd Bannister | | 506 | 537 | -31 |
| 1982-08-23 | vs BOS | 124 | L 3-4 | 59-65 | 4 | 11,748 | Gaylord Perry | John Tudor | Mark Clear | Bill Caudill | | 509 | 541 | -32 |
| 1982-08-24 | vs BOS | 125 | L 4-5 | 59-66 | 4 | 27,087 | Bob Stoddard | Bruce Hurst | Tom Burgmeier | Bill Caudill | | 513 | 546 | -33 |
| 1982-08-26 | vs DET | 126 | W 5-4 | 60-66 | 4 | 7,907 | Mike Moore | Jack Morris | Bill Caudill | Jack Morris | | 518 | 550 | -32 |
| 1982-08-27 | vs DET | 127 | L 1-6 | 60-67 | 4 | 8,986 | Jim Beattie | Milt Wilcox | Milt Wilcox | Jim Beattie | Dave Tobik | 519 | 556 | -37 |
| 1982-08-28 | vs DET | 128 | W 4-3 | 61-67 | 4 | 10,120 | Floyd Bannister | Dan Petry | Ron Musselman | Dave Tobik | | 523 | 559 | -36 |
| 1982-08-29 | vs DET | 129 | L 2-6 | 61-68 | 4 | 8,998 | Gaylord Perry | Jerry Ujdur | Jerry Ujdur | Gaylord Perry | | 525 | 565 | -40 |
| 1982-08-30 | @ MIL | 130 | W 3-2 | 62-68 | 4 | 13,008 | Bob Stoddard | Pete Vuckovich | Ed Vande Berg | Jim Slaton | | 528 | 567 | -39 |
| 1982-08-31 | @ MIL | 131 | L 2-8 | 62-69 | 4 | 8,631 | Bryan Clark | Mike Caldwell | Mike Caldwell | Bryan Clark | | 530 | 575 | -45 |
| 1982-09-01 | @ MIL | 132 | L 3-7 | 62-70 | 4 | 10,782 | Mike Stanton | Doc Medich | Doc Medich | Mike Stanton | | 533 | 582 | -49 |
| 1982-09-03 | @ BOS | 133 | L 8-10 | 62-71 | 4 | 22,586 | Floyd Bannister | John Tudor | John Tudor | Floyd Bannister | Bob Stanley | 541 | 592 | -51 |
| 1982-09-04 | @ BOS | 134 | W 4-3 | 63-71 | 4 | 21,744 | Gaylord Perry | Dennis Eckersley | Gaylord Perry | Bruce Hurst | Bill Caudill | 545 | 595 | -50 |
| 1982-09-05 | @ BOS | 135 | L 5-6 | 63-72 | 4 | 22,717 | Bob Stoddard | Chuck Rainey | Mark Clear | Bill Caudill | | 550 | 601 | -51 |
| 1982-09-06 | vs KCA | 136 | W 6-2 | 64-72 | 4 | 10,030 | Floyd Bannister | Buddy Black | Floyd Bannister | Buddy Black | | 556 | 603 | -47 |
| 1982-09-07 | vs KCA | 137 | W 5-2 | 65-72 | 4 | 6,191 | Mike Moore | Paul Splittorff | Mike Moore | Paul Splittorff | Bill Caudill | 561 | 605 | -44 |
| 1982-09-08 | vs KCA | 138 | L 2-6 | 65-73 | 4 | 7,925 | Jim Beattie | Vida Blue | Vida Blue | Jim Beattie | | 563 | 611 | -48 |
| 1982-09-10 | @ TEX | 139 | W 5-2 | 66-73 | 4 | 8,351 | Gaylord Perry | Frank Tanana | Gaylord Perry | Frank Tanana | Ed Vande Berg | 568 | 613 | -45 |
| 1982-09-11 | @ TEX | 140 | L 2-5 | 66-74 | 4 | 8,676 | Floyd Bannister | Charlie Hough | Charlie Hough | Floyd Bannister | | 570 | 618 | -48 |
| 1982-09-12 | @ TEX | 141 | W 1-0 | 67-74 | 4 | 6,418 | Bob Stoddard | Mike Smithson | Bob Stoddard | Mike Smithson | Bill Caudill | 571 | 618 | -47 |
| 1982-09-13 | @ KCA | 142 | L 0-8 | 67-75 | 4 | 19,508 | Mike Moore | Vida Blue | Vida Blue | Mike Moore | | 571 | 626 | -55 |
| 1982-09-14 | @ KCA | 143 | L 2-5 | 67-76 | 4 | 16,826 | Jim Beattie | Bill Castro | Bill Castro | Jim Beattie | Bob Tufts | 573 | 631 | -58 |
| 1982-09-15 | @ KCA | 144 | L 4-5 | 67-77 | 4 | 17,151 | Gaylord Perry | Larry Gura | Dan Quisenberry | Bill Caudill | | 577 | 636 | -59 |
| 1982-09-16 | @ KCA | 145 | W 4-2 | 68-77 | 4 | 16,809 | Floyd Bannister | Dennis Leonard | Ed Vande Berg | Dennis Leonard | Mike Stanton | 581 | 638 | -57 |
| 1982-09-17 | vs TEX | 146 | W 6-0 | 69-77 | 4 | 5,535 | Bob Stoddard | Mike Smithson | Bob Stoddard | Mike Smithson | | 587 | 638 | -51 |
| 1982-09-18 | vs TEX | 147 | L 4-10 | 69-78 | 4 | 10,174 | Mike Moore | Mike Mason | Mike Mason | Mike Moore | John Butcher | 591 | 648 | -57 |
| 1982-09-19 | vs TEX | 148 | W 9-7 | 70-78 | 4 | 6,339 | Ed Nunez | Rick Honeycutt | Ed Nunez | Rick Honeycutt | Bill Caudill | 600 | 655 | -55 |
| 1982-09-20 | vs CHA | 149 | W 5-2 | 71-78 | 4 | 4,429 | Bryan Clark | LaMarr Hoyt | Bryan Clark | LaMarr Hoyt | Ed Vande Berg | 605 | 657 | -52 |
| 1982-09-21 | vs CHA | 150 | W 5-4 | 72-78 | 4 | 5,157 | Floyd Bannister | Britt Burns | Bill Caudill | Kevin Hickey | | 610 | 661 | -51 |
| 1982-09-22 | vs CHA | 151 | W 8-4 | 73-78 | 4 | 5,057 | Bob Stoddard | Richard Dotson | Bob Stoddard | Richard Dotson | Ed Vande Berg | 618 | 665 | -47 |
| 1982-09-23 | vs CHA | 152 | L 4-12 | 73-79 | 4 | 6,543 | Mike Moore | Jerry Koosman | Jerry Koosman | Mike Moore | | 622 | 677 | -55 |
| 1982-09-24 | vs TOR | 153 | W 3-2 | 74-79 | 4 | 14,071 | Ed Nunez | Mark Eichhorn | Ed Vande Berg | Dale Murray | | 625 | 679 | -54 |
| 1982-09-25 | vs TOR | 154 | W 7-0 | 75-79 | 4 | 18,818 | Bryan Clark | Luis Leal | Bryan Clark | Luis Leal | | 632 | 679 | -47 |
| 1982-09-26 | vs TOR | 155 | L 2-6 | 75-80 | 4 | 6,742 | Floyd Bannister | Dave Stieb | Dave Stieb | Floyd Bannister | | 634 | 685 | -51 |
| 1982-09-27 | @ CHA | 156 | W 8-4 | 76-81 | 4 | 0 | Gaylord Perry | Jerry Koosman | Gaylord Perry | Jerry Koosman | | 642 | 689 | -47 |
| 1982-09-27 | @ CHA | 157 | L 1-4 | 76-81 | 4 | 6,054 | Bob Stoddard | Jim Kern | Jim Kern | Bob Stoddard | Salome Barojas | 643 | 693 | -50 |
| 1982-09-28 | @ CHA | 158 | L 1-3 | 76-82 | 4 | 5,647 | Mike Moore | Dennis Lamp | Dennis Lamp | Mike Moore | Salome Barojas | 644 | 696 | -52 |
| 1982-09-29 | @ CHA | 159 | L 5-6 | 76-83 | 4 | 19,531 | Ed Nunez | LaMarr Hoyt | LaMarr Hoyt | Ed Nunez | Salome Barojas | 649 | 702 | -53 |
| 1982-10-01 | @ TOR | 160 | L 0-2 | 76-84 | 4 | 11,171 | Floyd Bannister | Dave Stieb | Dave Stieb | Floyd Bannister | | 649 | 704 | -55 |
| 1982-10-02 | @ TOR | 161 | L 0-3 | 76-85 | 4 | 12,472 | Bob Stoddard | Jim Gott | Jim Gott | Bob Stoddard | Roy Lee Jackson | 649 | 707 | -58 |
| 1982-10-03 | @ TOR | 162 | L 2-5 | 76-86 | 4 | 19,064 | Mike Moore | Jim Clancy | Jim Clancy | Bill Caudill | | 651 | 712 | -61 |