| 1982-04-06 | @ LAN | 1 | L 3-4 | 0-1 | 6 | 49,662 | Al Holland | Jerry Reuss | Terry Forster | Gary Lavelle | | 3 | 4 | -1 |
| 1982-04-07 | @ LAN | 2 | L 2-9 | 0-2 | 6 | 36,207 | Alan Fowlkes | Bob Welch | Bob Welch | Fred Breining | | 5 | 13 | -8 |
| 1982-04-09 | @ CIN | 3 | L 0-7 | 0-3 | 6 | 10,069 | Dan Schatzeder | Frank Pastore | Frank Pastore | Dan Schatzeder | | 5 | 20 | -15 |
| 1982-04-10 | @ CIN | 4 | W 7-5 | 1-3 | 6 | 11,906 | Rich Gale | Mario Soto | Greg Minton | Tom Hume | Jim Barr | 12 | 25 | -13 |
| 1982-04-11 | @ CIN | 5 | W 6-1 | 2-3 | 4 | 11,205 | Al Holland | Charlie Leibrandt | Al Holland | Charlie Leibrandt | | 18 | 26 | -8 |
| 1982-04-13 | vs SDN | 6 | W 3-2 | 3-3 | 3 | 41,410 | Alan Fowlkes | John Montefusco | Alan Fowlkes | John Montefusco | Greg Minton | 21 | 28 | -7 |
| 1982-04-14 | vs SDN | 7 | L 2-3 | 3-4 | 4 | 6,212 | Dan Schatzeder | Tim Lollar | Tim Lollar | Dan Schatzeder | Gary Lucas | 23 | 31 | -8 |
| 1982-04-16 | vs CIN | 8 | W 6-1 | 4-4 | 3 | 10,201 | Rich Gale | Mario Soto | Rich Gale | Mario Soto | | 29 | 32 | -3 |
| 1982-04-17 | vs CIN | 9 | L 2-8 | 4-5 | 3 | 11,605 | Al Holland | Bruce Berenyi | Bruce Berenyi | Al Holland | Tom Hume | 31 | 40 | -9 |
| 1982-04-18 | vs CIN | 10 | W 4-2 | 5-5 | 3 | 39,154 | Alan Fowlkes | Tom Seaver | Alan Fowlkes | Tom Seaver | Greg Minton | 35 | 42 | -7 |
| 1982-04-19 | @ SDN | 11 | L 6-13 | 5-6 | 3 | 17,121 | Dan Schatzeder | Juan Eichelberger | Juan Eichelberger | Dan Schatzeder | | 41 | 55 | -14 |
| 1982-04-20 | @ SDN | 12 | L 4-8 | 5-7 | 3 | 17,865 | Rich Gale | John Curtis | John Curtis | Rich Gale | Danny Boone | 45 | 63 | -18 |
| 1982-04-21 | @ SDN | 13 | L 6-7 | 5-8 | 4 | 24,577 | Al Holland | John Montefusco | John Montefusco | Al Holland | Gary Lucas | 51 | 70 | -19 |
| 1982-04-23 | vs LAN | 14 | L 0-9 | 5-9 | 5 | 26,900 | Alan Fowlkes | Bob Welch | Bob Welch | Alan Fowlkes | | 51 | 79 | -28 |
| 1982-04-24 | vs LAN | 15 | L 6-7 | 5-10 | 5 | 28,832 | Jim Barr | Burt Hooton | Steve Howe | Greg Minton | Terry Forster | 57 | 86 | -29 |
| 1982-04-25 | vs LAN | 16 | W 6-3 | 6-10 | 4 | 47,808 | Rich Gale | Fernando Valenzuela | Fred Breining | Fernando Valenzuela | Gary Lavelle | 63 | 89 | -26 |
| 1982-04-27 | vs MON | 17 | L 2-3 | 6-11 | 6 | 5,587 | Al Holland | Steve Rogers | Steve Rogers | Al Holland | | 65 | 92 | -27 |
| 1982-04-28 | vs MON | 18 | W 7-0 | 7-11 | 4 | 6,065 | Bill Laskey | Bill Gullickson | Bill Laskey | Bill Gullickson | | 72 | 92 | -20 |
| 1982-04-29 | vs MON | 19 | W 7-3 | 8-11 | 4 | 5,484 | Alan Fowlkes | Ray Burris | Alan Fowlkes | Ray Burris | | 79 | 95 | -16 |
| 1982-04-30 | vs NYN | 20 | W 5-4 | 9-11 | 4 | 5,961 | Rich Gale | Mike Scott | Fred Breining | Neil Allen | | 84 | 99 | -15 |
| 1982-05-01 | vs NYN | 21 | W 6-3 | 10-11 | 4 | 6,466 | Atlee Hammaker | Pat Zachry | Atlee Hammaker | Pat Zachry | Greg Minton | 90 | 102 | -12 |
| 1982-05-02 | vs NYN | 22 | W 4-3 | 11-12 | 4 | 0 | Al Holland | Ed Lynch | Al Holland | Ed Lynch | Greg Minton | 94 | 105 | -11 |
| 1982-05-02 | vs NYN | 23 | L 0-2 | 11-12 | 4 | 20,543 | Bill Laskey | Randy Jones | Randy Jones | Bill Laskey | Neil Allen | 94 | 107 | -13 |
| 1982-05-03 | vs PHI | 24 | L 3-5 | 11-13 | 4 | 12,022 | Alan Fowlkes | Dick Ruthven | Sid Monge | Dan Schatzeder | Ed Farmer | 97 | 112 | -15 |
| 1982-05-04 | vs PHI | 25 | L 4-9 | 11-14 | 5 | 5,656 | Rich Gale | Steve Carlton | Steve Carlton | Rich Gale | | 101 | 121 | -20 |
| 1982-05-06 | @ NYN | 26 | W 5-3 | 12-14 | 4 | 10,013 | Atlee Hammaker | Randy Jones | Greg Minton | Jesse Orosco | | 106 | 124 | -18 |
| 1982-05-07 | @ NYN | 27 | L 2-3 | 12-15 | 5 | 16,782 | Bill Laskey | Charlie Puleo | Charlie Puleo | Bill Laskey | Neil Allen | 108 | 127 | -19 |
| 1982-05-08 | @ NYN | 28 | W 8-3 | 13-15 | 4 | 17,448 | Al Holland | Mike Scott | Gary Lavelle | Ed Lynch | | 116 | 130 | -14 |
| 1982-05-09 | @ NYN | 29 | L 5-6 | 13-16 | 4 | 15,008 | Alan Fowlkes | Pete Falcone | Craig Swan | Greg Minton | | 121 | 136 | -15 |
| 1982-05-10 | @ MON | 30 | L 4-5 | 13-17 | 5 | 18,307 | Rich Gale | Charlie Lea | Woodie Fryman | Gary Lavelle | Jeff Reardon | 125 | 141 | -16 |
| 1982-05-11 | @ MON | 31 | W 5-4 | 14-17 | 4 | 16,298 | Atlee Hammaker | Scott Sanderson | Atlee Hammaker | Scott Sanderson | Greg Minton | 130 | 145 | -15 |
| 1982-05-12 | @ MON | 32 | W 3-2 | 15-17 | 4 | 13,019 | Bill Laskey | Steve Rogers | Bill Laskey | Steve Rogers | Greg Minton | 133 | 147 | -14 |
| 1982-05-13 | @ PHI | 33 | L 1-8 | 15-18 | 4 | 23,053 | Alan Fowlkes | Dick Ruthven | Dick Ruthven | Alan Fowlkes | | 134 | 155 | -21 |
| 1982-05-14 | @ PHI | 34 | L 0-2 | 15-19 | 4 | 33,541 | Rich Gale | Steve Carlton | Steve Carlton | Rich Gale | | 134 | 157 | -23 |
| 1982-05-15 | @ PHI | 35 | L 3-5 | 15-20 | 5 | 29,785 | Renie Martin | Larry Christenson | Larry Christenson | Greg Minton | Sparky Lyle | 137 | 162 | -25 |
| 1982-05-16 | @ PHI | 36 | L 1-6 | 15-21 | 6 | 38,125 | Atlee Hammaker | Mike Krukow | Mike Krukow | Atlee Hammaker | | 138 | 168 | -30 |
| 1982-05-18 | vs PIT | 37 | W 2-1 | 16-21 | 6 | 8,925 | Bill Laskey | John Candelaria | Bill Laskey | John Candelaria | | 140 | 169 | -29 |
| 1982-05-19 | vs PIT | 38 | L 1-2 | 16-22 | 6 | 5,042 | Mike Chris | Don Robinson | Don Robinson | Mike Chris | Kent Tekulve | 141 | 171 | -30 |
| 1982-05-20 | vs PIT | 39 | W 3-1 | 17-22 | 5 | 4,085 | Rich Gale | Rick Rhoden | Gary Lavelle | Rod Scurry | | 144 | 172 | -28 |
| 1982-05-21 | vs CHN | 40 | L 4-6 | 17-23 | 5 | 20,650 | Renie Martin | Doug Bird | Dick Tidrow | Renie Martin | Bill Campbell | 148 | 178 | -30 |
| 1982-05-22 | vs CHN | 41 | L 1-2 | 17-24 | 5 | 8,401 | Atlee Hammaker | Allen Ripley | Allen Ripley | Atlee Hammaker | Guillermo Hernandez | 149 | 180 | -31 |
| 1982-05-23 | vs CHN | 42 | W 4-3 | 19-24 | 5 | 0 | Bill Laskey | Randy Martz | Gary Lavelle | Dick Tidrow | | 153 | 183 | -30 |
| 1982-05-23 | vs CHN | 43 | W 6-3 | 19-24 | 5 | 17,865 | Mike Chris | Dan Larson | Dan Schatzeder | Dan Larson | Jim Barr | 159 | 186 | -27 |
| 1982-05-24 | vs SLN | 44 | L 0-6 | 19-25 | 5 | 13,290 | Rich Gale | Joaquin Andujar | Joaquin Andujar | Rich Gale | | 159 | 192 | -33 |
| 1982-05-25 | vs SLN | 45 | L 3-8 | 19-26 | 5 | 5,650 | Renie Martin | Dave LaPoint | Dave LaPoint | Renie Martin | | 162 | 200 | -38 |
| 1982-05-26 | vs SLN | 46 | L 4-8 | 19-27 | 6 | 6,187 | Atlee Hammaker | Steve Mura | Steve Mura | Atlee Hammaker | Bruce Sutter | 166 | 208 | -42 |
| 1982-05-28 | @ PIT | 47 | W 10-5 | 20-27 | 5 | 7,273 | Bill Laskey | John Candelaria | Bill Laskey | John Candelaria | | 176 | 213 | -37 |
| 1982-05-29 | @ PIT | 48 | W 9-5 | 21-27 | 5 | 8,283 | Mike Chris | Don Robinson | Jim Barr | Don Robinson | | 185 | 218 | -33 |
| 1982-05-30 | @ PIT | 49 | L 6-7 | 21-28 | 5 | 18,279 | Rich Gale | Rick Rhoden | Eddie Solomon | Jim Barr | | 191 | 225 | -34 |
| 1982-05-31 | @ SLN | 50 | L 6-11 | 21-29 | 5 | 11,313 | Renie Martin | Steve Mura | John Martin | Renie Martin | | 197 | 236 | -39 |
| 1982-06-01 | @ SLN | 51 | W 4-3 | 22-29 | 4 | 15,964 | Atlee Hammaker | John Stuper | Greg Minton | Jim Kaat | Gary Lavelle | 201 | 239 | -38 |
| 1982-06-02 | @ SLN | 52 | L 0-1 | 22-30 | 5 | 13,977 | Bill Laskey | Joaquin Andujar | Joaquin Andujar | Bill Laskey | | 201 | 240 | -39 |
| 1982-06-04 | @ CHN | 53 | W 4-3 | 23-30 | 5 | 7,034 | Mike Chris | Fergie Jenkins | Fred Breining | Fergie Jenkins | Greg Minton | 205 | 243 | -38 |
| 1982-06-05 | @ CHN | 54 | W 2-1 | 24-30 | 4 | 24,072 | Rich Gale | Doug Bird | Rich Gale | Doug Bird | Greg Minton | 207 | 244 | -37 |
| 1982-06-06 | @ CHN | 55 | W 5-3 | 25-30 | 4 | 14,730 | Renie Martin | Randy Martz | Renie Martin | Randy Martz | Greg Minton | 212 | 247 | -35 |
| 1982-06-08 | vs HOU | 56 | W 7-3 | 26-30 | 4 | 9,426 | Atlee Hammaker | Nolan Ryan | Atlee Hammaker | Nolan Ryan | Gary Lavelle | 219 | 250 | -31 |
| 1982-06-09 | vs HOU | 57 | L 1-6 | 26-31 | 4 | 7,217 | Bill Laskey | Joe Niekro | Joe Niekro | Bill Laskey | | 220 | 256 | -36 |
| 1982-06-11 | vs ATL | 58 | L 3-5 | 26-32 | 4 | 21,487 | Mike Chris | Bob Walk | Bob Walk | Mike Chris | Gene Garber | 223 | 261 | -38 |
| 1982-06-12 | vs ATL | 59 | L 5-10 | 26-33 | 4 | 10,569 | Rich Gale | Phil Niekro | Phil Niekro | Rich Gale | Al Hrabosky | 228 | 271 | -43 |
| 1982-06-13 | vs ATL | 60 | W 2-1 | 27-34 | 4 | 0 | Renie Martin | Ken Dayley | Renie Martin | Ken Dayley | Greg Minton | 230 | 272 | -42 |
| 1982-06-13 | vs ATL | 61 | L 1-5 | 27-34 | 4 | 27,521 | Atlee Hammaker | Rick Camp | Rick Camp | Atlee Hammaker | Gene Garber | 231 | 277 | -46 |
| 1982-06-15 | @ CIN | 62 | W 4-3 | 28-34 | 4 | 21,416 | Bill Laskey | Tom Seaver | Bill Laskey | Tom Seaver | Gary Lavelle | 235 | 280 | -45 |
| 1982-06-16 | @ CIN | 63 | L 3-7 | 28-35 | 4 | 18,127 | Mike Chris | Mario Soto | Mario Soto | Jim Barr | Tom Hume | 238 | 287 | -49 |
| 1982-06-17 | @ CIN | 64 | L 2-4 | 28-36 | 4 | 18,808 | Rich Gale | Charlie Leibrandt | Charlie Leibrandt | Rich Gale | Tom Hume | 240 | 291 | -51 |
| 1982-06-18 | @ ATL | 65 | L 3-8 | 28-37 | 4 | 29,247 | Renie Martin | Ken Dayley | Ken Dayley | Renie Martin | Rick Camp | 243 | 299 | -56 |
| 1982-06-19 | @ ATL | 66 | W 9-4 | 29-37 | 4 | 30,497 | Atlee Hammaker | Rick Mahler | Gary Lavelle | Gene Garber | | 252 | 303 | -51 |
| 1982-06-20 | @ ATL | 67 | W 5-3 | 30-37 | 4 | 18,556 | Bill Laskey | Bob Walk | Bill Laskey | Bob Walk | Greg Minton | 257 | 306 | -49 |
| 1982-06-21 | @ ATL | 68 | L 6-7 | 30-38 | 4 | 10,485 | Alan Fowlkes | Phil Niekro | Rick Camp | Greg Minton | | 263 | 313 | -50 |
| 1982-06-22 | @ HOU | 69 | L 0-2 | 30-39 | 4 | 12,966 | Rich Gale | Vern Ruhle | Vern Ruhle | Rich Gale | | 263 | 315 | -52 |
| 1982-06-23 | @ HOU | 70 | W 9-8 | 31-39 | 4 | 14,295 | Renie Martin | Nolan Ryan | Fred Breining | Frank LaCorte | Greg Minton | 272 | 323 | -51 |
| 1982-06-24 | @ HOU | 71 | W 4-3 | 32-39 | 4 | 13,782 | Atlee Hammaker | Joe Niekro | Atlee Hammaker | Joe Niekro | | 276 | 326 | -50 |
| 1982-06-25 | vs SDN | 72 | L 2-3 | 32-40 | 4 | 10,269 | Bill Laskey | Juan Eichelberger | Juan Eichelberger | Bill Laskey | Gary Lucas | 278 | 329 | -51 |
| 1982-06-26 | vs SDN | 73 | L 6-7 | 32-41 | 4 | 8,612 | Alan Fowlkes | John Curtis | Eric Show | Gary Lavelle | | 284 | 336 | -52 |
| 1982-06-27 | vs SDN | 74 | L 2-4 | 32-42 | 4 | 23,387 | Rich Gale | Tim Lollar | Tim Lollar | Rich Gale | Floyd Chiffer | 286 | 340 | -54 |
| 1982-06-28 | vs CIN | 75 | W 7-1 | 33-42 | 4 | 10,867 | Renie Martin | Charlie Leibrandt | Renie Martin | Charlie Leibrandt | | 293 | 341 | -48 |
| 1982-06-29 | vs CIN | 76 | W 3-0 | 34-42 | 4 | 4,394 | Atlee Hammaker | Bob Shirley | Atlee Hammaker | Bob Shirley | | 296 | 341 | -45 |
| 1982-06-30 | vs CIN | 77 | W 7-6 | 35-42 | 4 | 4,358 | Bill Laskey | Bruce Berenyi | Greg Minton | Charlie Leibrandt | | 303 | 347 | -44 |
| 1982-07-02 | @ SDN | 78 | W 8-4 | 36-43 | 4 | 0 | Alan Fowlkes | John Curtis | Al Holland | Dave Dravecky | | 311 | 351 | -40 |
| 1982-07-02 | @ SDN | 79 | L 2-3 | 36-43 | 4 | 26,120 | Rich Gale | Tim Lollar | Tim Lollar | Gary Lavelle | Gary Lucas | 313 | 354 | -41 |
| 1982-07-03 | @ SDN | 80 | W 4-3 | 37-43 | 4 | 44,981 | Renie Martin | Chris Welsh | Greg Minton | Floyd Chiffer | | 317 | 357 | -40 |
| 1982-07-04 | @ SDN | 81 | L 3-4 | 37-44 | 4 | 12,567 | Atlee Hammaker | John Montefusco | Dave Dravecky | Atlee Hammaker | | 320 | 361 | -41 |
| 1982-07-05 | @ PHI | 82 | W 3-1 | 38-44 | 4 | 63,501 | Bill Laskey | Dick Ruthven | Bill Laskey | Dick Ruthven | | 323 | 362 | -39 |
| 1982-07-06 | @ PHI | 83 | L 2-3 | 38-45 | 4 | 22,470 | Alan Fowlkes | Larry Christenson | Sparky Lyle | Fred Breining | Tug McGraw | 325 | 365 | -40 |
| 1982-07-07 | @ NYN | 84 | W 3-2 | 39-45 | 4 | 13,875 | Rich Gale | Brent Gaff | Rich Gale | Brent Gaff | Greg Minton | 328 | 367 | -39 |
| 1982-07-08 | @ NYN | 85 | W 9-7 | 40-45 | 4 | 12,087 | Renie Martin | Jesse Orosco | Renie Martin | Jesse Orosco | Greg Minton | 337 | 374 | -37 |
| 1982-07-09 | @ MON | 86 | W 3-2 | 41-45 | 4 | 31,339 | Atlee Hammaker | Steve Rogers | Atlee Hammaker | Steve Rogers | Greg Minton | 340 | 376 | -36 |
| 1982-07-10 | @ MON | 87 | L 4-8 | 41-46 | 4 | 36,076 | Bill Laskey | Bill Gullickson | Bill Gullickson | Bill Laskey | Woodie Fryman | 344 | 384 | -40 |
| 1982-07-11 | @ MON | 88 | W 8-7 | 42-46 | 4 | 36,090 | Alan Fowlkes | Scott Sanderson | Greg Minton | Jeff Reardon | | 352 | 391 | -39 |
| 1982-07-15 | vs PHI | 89 | L 1-2 | 42-47 | 4 | 8,004 | Rich Gale | Mike Krukow | Mike Krukow | Rich Gale | Tug McGraw | 353 | 393 | -40 |
| 1982-07-16 | vs PHI | 90 | L 0-1 | 42-48 | 4 | 7,720 | Bill Laskey | Steve Carlton | Steve Carlton | Bill Laskey | | 353 | 394 | -41 |
| 1982-07-17 | vs PHI | 91 | L 3-5 | 42-49 | 4 | 30,790 | Renie Martin | Dick Ruthven | Ron Reed | Fred Breining | Sid Monge | 356 | 399 | -43 |
| 1982-07-18 | vs PHI | 92 | W 4-3 | 43-49 | 4 | 15,657 | Atlee Hammaker | Larry Christenson | Atlee Hammaker | Larry Christenson | | 360 | 402 | -42 |
| 1982-07-20 | vs NYN | 93 | W 5-1 | 44-49 | 4 | 9,569 | Rich Gale | Charlie Puleo | Rich Gale | Charlie Puleo | Al Holland | 365 | 403 | -38 |
| 1982-07-21 | vs NYN | 94 | L 2-6 | 44-50 | 4 | 7,916 | Bill Laskey | Pete Falcone | Pete Falcone | Bill Laskey | Jesse Orosco | 367 | 409 | -42 |
| 1982-07-23 | vs MON | 95 | L 7-8 | 44-51 | 4 | 6,724 | Renie Martin | Bill Gullickson | Ray Burris | Gary Lavelle | | 374 | 417 | -43 |
| 1982-07-24 | vs MON | 96 | W 5-2 | 45-51 | 4 | 10,055 | Atlee Hammaker | David Palmer | Atlee Hammaker | David Palmer | | 379 | 419 | -40 |
| 1982-07-25 | vs MON | 97 | W 3-2 | 46-51 | 4 | 15,542 | Rich Gale | Scott Sanderson | Rich Gale | Scott Sanderson | Greg Minton | 382 | 421 | -39 |
| 1982-07-26 | vs LAN | 98 | W 6-1 | 47-51 | 4 | 47,225 | Bill Laskey | Fernando Valenzuela | Bill Laskey | Fernando Valenzuela | | 388 | 422 | -34 |
| 1982-07-27 | vs LAN | 99 | L 3-7 | 47-52 | 4 | 15,442 | Renie Martin | Vicente Romo | Joe Beckwith | Renie Martin | | 391 | 429 | -38 |
| 1982-07-28 | vs LAN | 100 | W 6-2 | 48-52 | 4 | 14,054 | Fred Breining | Dave Stewart | Fred Breining | Dave Stewart | Gary Lavelle | 397 | 431 | -34 |
| 1982-07-30 | @ HOU | 101 | L 1-3 | 48-53 | 4 | 17,407 | Rich Gale | Don Sutton | Don Sutton | Rich Gale | | 398 | 434 | -36 |
| 1982-07-31 | @ HOU | 102 | W 5-4 | 49-54 | 4 | 0 | Bill Laskey | Vern Ruhle | Bill Laskey | Vern Ruhle | Greg Minton | 403 | 438 | -35 |
| 1982-07-31 | @ HOU | 103 | L 0-5 | 49-54 | 4 | 28,190 | Atlee Hammaker | Mike LaCoss | Mike LaCoss | Atlee Hammaker | Frank LaCorte | 403 | 443 | -40 |
| 1982-08-01 | @ HOU | 104 | W 4-2 | 50-54 | 4 | 20,108 | Renie Martin | Nolan Ryan | Greg Minton | Frank LaCorte | | 407 | 445 | -38 |
| 1982-08-02 | @ ATL | 105 | L 3-7 | 50-55 | 4 | 15,018 | Fred Breining | Bob Walk | Bob Walk | Fred Breining | Steve Bedrosian | 410 | 452 | -42 |
| 1982-08-03 | @ ATL | 106 | W 6-3 | 51-55 | 4 | 21,489 | Rich Gale | Rick Camp | Greg Minton | Gene Garber | | 416 | 455 | -39 |
| 1982-08-04 | @ ATL | 107 | W 3-2 | 52-55 | 4 | 13,607 | Alan Fowlkes | Joe Cowley | Gary Lavelle | Steve Bedrosian | Greg Minton | 419 | 457 | -38 |
| 1982-08-05 | vs HOU | 108 | W 5-2 | 53-55 | 4 | 5,357 | Bill Laskey | Vern Ruhle | Bill Laskey | Vern Ruhle | Greg Minton | 424 | 459 | -35 |
| 1982-08-06 | vs HOU | 109 | W 7-6 | 54-55 | 4 | 8,430 | Atlee Hammaker | Nolan Ryan | Gary Lavelle | Randy Moffitt | | 431 | 465 | -34 |
| 1982-08-07 | vs HOU | 110 | W 9-2 | 55-55 | 4 | 11,780 | Renie Martin | Joe Niekro | Renie Martin | Joe Niekro | | 440 | 467 | -27 |
| 1982-08-08 | vs HOU | 111 | W 3-2 | 57-55 | 4 | 0 | Rich Gale | Bob Knepper | Fred Breining | Bob Knepper | | 443 | 469 | -26 |
| 1982-08-08 | vs HOU | 112 | W 8-3 | 57-55 | 4 | 22,937 | Alan Fowlkes | Mike LaCoss | Gary Lavelle | Mike LaCoss | | 451 | 472 | -21 |
| 1982-08-09 | vs ATL | 113 | W 5-0 | 58-55 | 4 | 29,846 | Jim Barr | Pascual Perez | Jim Barr | Pascual Perez | | 456 | 472 | -16 |
| 1982-08-10 | vs ATL | 114 | W 3-2 | 59-55 | 4 | 19,390 | Bill Laskey | Rick Mahler | Bill Laskey | Al Hrabosky | | 459 | 474 | -15 |
| 1982-08-11 | vs ATL | 115 | W 8-6 | 60-55 | 4 | 22,940 | Atlee Hammaker | Phil Niekro | Fred Breining | Carlos Diaz | | 467 | 480 | -13 |
| 1982-08-12 | @ LAN | 116 | L 2-6 | 60-56 | 4 | 47,725 | Renie Martin | Jerry Reuss | Tom Niedenfuer | Renie Martin | | 469 | 486 | -17 |
| 1982-08-13 | @ LAN | 117 | L 1-6 | 60-57 | 4 | 47,702 | Rich Gale | Bob Welch | Bob Welch | Rich Gale | | 470 | 492 | -22 |
| 1982-08-14 | @ LAN | 118 | W 4-2 | 61-57 | 4 | 50,955 | Jim Barr | Dave Stewart | Jim Barr | Dave Stewart | Greg Minton | 474 | 494 | -20 |
| 1982-08-15 | @ LAN | 119 | W 8-6 | 62-57 | 4 | 48,352 | Bill Laskey | Fernando Valenzuela | Bill Laskey | Fernando Valenzuela | Greg Minton | 482 | 500 | -18 |
| 1982-08-17 | @ PIT | 120 | L 1-4 | 62-58 | 4 | 11,345 | Atlee Hammaker | Rick Rhoden | Rick Rhoden | Atlee Hammaker | | 483 | 504 | -21 |
| 1982-08-18 | @ PIT | 121 | W 16-9 | 63-58 | 4 | 14,205 | Renie Martin | Don Robinson | Alan Fowlkes | Don Robinson | | 499 | 513 | -14 |
| 1982-08-19 | @ PIT | 122 | L 1-6 | 63-59 | 4 | 8,015 | Rich Gale | John Candelaria | John Candelaria | Rich Gale | | 500 | 519 | -19 |
| 1982-08-20 | @ SLN | 123 | W 8-7 | 64-59 | 4 | 28,413 | Jim Barr | Steve Mura | Gary Lavelle | Bruce Sutter | Greg Minton | 508 | 526 | -18 |
| 1982-08-21 | @ SLN | 124 | L 6-7 | 64-60 | 4 | 35,376 | Bill Laskey | Dave LaPoint | Dave LaPoint | Bill Laskey | Bruce Sutter | 514 | 533 | -19 |
| 1982-08-22 | @ SLN | 125 | L 4-5 | 64-61 | 4 | 46,827 | Atlee Hammaker | Joaquin Andujar | Jeff Lahti | Gary Lavelle | | 518 | 538 | -20 |
| 1982-08-23 | @ CHN | 126 | L 5-8 | 64-62 | 4 | 13,780 | Renie Martin | Doug Bird | Doug Bird | Renie Martin | Dick Tidrow | 523 | 546 | -23 |
| 1982-08-24 | @ CHN | 127 | L 4-8 | 64-63 | 4 | 13,712 | Rich Gale | Fergie Jenkins | Fergie Jenkins | Rich Gale | | 527 | 554 | -27 |
| 1982-08-25 | @ CHN | 128 | L 2-4 | 64-64 | 4 | 17,291 | Jim Barr | Randy Martz | Randy Martz | Jim Barr | Lee Smith | 529 | 558 | -29 |
| 1982-08-27 | vs PIT | 129 | L 2-3 | 64-65 | 4 | 9,820 | Bill Laskey | Rick Rhoden | Rick Rhoden | Bill Laskey | Rod Scurry | 531 | 561 | -30 |
| 1982-08-28 | vs PIT | 130 | W 4-2 | 65-65 | 4 | 15,759 | Atlee Hammaker | Don Robinson | Atlee Hammaker | Don Robinson | Greg Minton | 535 | 563 | -28 |
| 1982-08-29 | vs PIT | 131 | L 3-4 | 65-66 | 4 | 22,017 | Renie Martin | John Candelaria | John Candelaria | Renie Martin | Rod Scurry | 538 | 567 | -29 |
| 1982-08-31 | vs CHN | 132 | W 4-3 | 66-66 | 4 | 8,827 | Fred Breining | Randy Martz | Al Holland | Guillermo Hernandez | Greg Minton | 542 | 570 | -28 |
| 1982-09-01 | vs CHN | 133 | L 6-7 | 66-67 | 4 | 7,463 | Bill Laskey | Allen Ripley | Bill Campbell | Rich Gale | Lee Smith | 548 | 577 | -29 |
| 1982-09-03 | vs SLN | 134 | W 3-2 | 67-67 | 4 | 6,901 | Atlee Hammaker | Bob Forsch | Greg Minton | Bruce Sutter | | 551 | 579 | -28 |
| 1982-09-04 | vs SLN | 135 | W 5-4 | 68-67 | 4 | 11,711 | Mark Dempsey | Dave LaPoint | Gary Lavelle | Bruce Sutter | | 556 | 583 | -27 |
| 1982-09-05 | vs SLN | 136 | W 5-1 | 69-67 | 4 | 19,577 | Fred Breining | John Stuper | Fred Breining | John Stuper | | 561 | 584 | -23 |
| 1982-09-06 | @ ATL | 137 | W 8-2 | 70-67 | 4 | 9,051 | Bill Laskey | Tommy Boggs | Al Holland | Donnie Moore | Greg Minton | 569 | 586 | -17 |
| 1982-09-07 | @ ATL | 138 | W 3-2 | 71-67 | 4 | 7,523 | Jim Barr | Rick Camp | Jim Barr | Rick Camp | Greg Minton | 572 | 588 | -16 |
| 1982-09-08 | @ HOU | 139 | L 1-8 | 71-68 | 4 | 9,880 | Atlee Hammaker | Joe Niekro | Joe Niekro | Atlee Hammaker | | 573 | 596 | -23 |
| 1982-09-09 | @ HOU | 140 | W 5-1 | 72-68 | 4 | 3,770 | Renie Martin | Mike LaCoss | Renie Martin | Mike LaCoss | Greg Minton | 578 | 597 | -19 |
| 1982-09-10 | @ SDN | 141 | W 5-1 | 73-68 | 4 | 13,341 | Fred Breining | Dave Dravecky | Fred Breining | Dave Dravecky | | 583 | 598 | -15 |
| 1982-09-11 | @ SDN | 142 | W 8-3 | 74-68 | 3 | 14,674 | Bill Laskey | Chris Welsh | Bill Laskey | Chris Welsh | Al Holland | 591 | 601 | -10 |
| 1982-09-13 | vs CIN | 143 | L 4-5 | 74-69 | 3 | 10,178 | Jim Barr | Frank Pastore | Joe Price | Gary Lavelle | Charlie Leibrandt | 595 | 606 | -11 |
| 1982-09-14 | vs CIN | 144 | W 2-1 | 75-69 | 3 | 3,728 | Atlee Hammaker | Bruce Berenyi | Atlee Hammaker | Bruce Berenyi | Al Holland | 597 | 607 | -10 |
| 1982-09-15 | vs CIN | 145 | W 5-4 | 76-69 | 3 | 3,858 | Renie Martin | Bob Shirley | Rich Gale | Joe Price | Gary Lavelle | 602 | 611 | -9 |
| 1982-09-16 | vs SDN | 146 | W 9-3 | 77-69 | 3 | 4,372 | Fred Breining | Tim Lollar | Fred Breining | Tim Lollar | Greg Minton | 611 | 614 | -3 |
| 1982-09-17 | vs SDN | 147 | L 2-4 | 77-70 | 3 | 8,342 | Bill Laskey | Dave Dravecky | Dave Dravecky | Bill Laskey | Gary Lucas | 613 | 618 | -5 |
| 1982-09-18 | vs SDN | 148 | W 4-1 | 78-70 | 3 | 35,888 | Rich Gale | Juan Eichelberger | Rich Gale | Juan Eichelberger | Gary Lavelle | 617 | 619 | -2 |
| 1982-09-19 | vs SDN | 149 | W 4-3 | 79-70 | 3 | 11,566 | Atlee Hammaker | Eric Show | Al Holland | Luis DeLeon | | 621 | 622 | -1 |
| 1982-09-21 | @ CIN | 150 | L 5-6 | 79-71 | 3 | 6,038 | Fred Breining | Bob Shirley | Bob Shirley | Fred Breining | Ben Hayes | 626 | 628 | -2 |
| 1982-09-22 | @ CIN | 151 | W 2-0 | 80-71 | 3 | 6,384 | Renie Martin | Mario Soto | Renie Martin | Mario Soto | Al Holland | 628 | 628 | 0 |
| 1982-09-23 | @ CIN | 152 | W 11-7 | 81-71 | 3 | 6,629 | Bill Laskey | Frank Pastore | Atlee Hammaker | Frank Pastore | | 639 | 635 | 4 |
| 1982-09-24 | @ LAN | 153 | W 3-2 | 82-71 | 3 | 50,666 | Rich Gale | Bob Welch | Al Holland | Steve Howe | Greg Minton | 642 | 637 | 5 |
| 1982-09-25 | @ LAN | 154 | W 5-4 | 83-71 | 3 | 49,634 | Jim Barr | Fernando Valenzuela | Andy McGaffigan | Fernando Valenzuela | Greg Minton | 647 | 641 | 6 |
| 1982-09-26 | @ LAN | 155 | W 3-2 | 84-71 | 3 | 46,331 | Fred Breining | Burt Hooton | Fred Breining | Burt Hooton | Al Holland | 650 | 643 | 7 |
| 1982-09-27 | vs ATL | 156 | L 0-7 | 84-72 | 3 | 45,783 | Renie Martin | Phil Niekro | Phil Niekro | Renie Martin | | 650 | 650 | 0 |
| 1982-09-28 | vs ATL | 157 | L 3-8 | 84-73 | 3 | 17,071 | Bill Laskey | Rick Mahler | Pascual Perez | Bill Laskey | | 653 | 658 | -5 |
| 1982-09-29 | vs HOU | 158 | W 6-1 | 85-73 | 3 | 8,117 | Atlee Hammaker | Joe Niekro | Atlee Hammaker | Joe Niekro | Gary Lavelle | 659 | 659 | 0 |
| 1982-09-30 | vs HOU | 159 | W 7-6 | 86-73 | 3 | 13,082 | Jim Barr | Mike LaCoss | Gary Lavelle | Danny Boone | | 666 | 665 | 1 |
| 1982-10-01 | vs LAN | 160 | L 0-4 | 86-74 | 3 | 53,281 | Fred Breining | Jerry Reuss | Jerry Reuss | Fred Breining | | 666 | 669 | -3 |
| 1982-10-02 | vs LAN | 161 | L 2-15 | 86-75 | 3 | 46,562 | Renie Martin | Bob Welch | Bob Welch | Renie Martin | Dave Stewart | 668 | 684 | -16 |
| 1982-10-03 | vs LAN | 162 | W 5-3 | 87-75 | 3 | 47,457 | Bill Laskey | Fernando Valenzuela | Greg Minton | Tom Niedenfuer | | 673 | 687 | -14 |