| 1982-04-11 | vs CHA | 1 | L 6-7 | 0-2 | 7 | 0 | Ron Guidry | Jerry Koosman | Kevin Hickey | Rich Gossage | | 6 | 7 | -1 |
| 1982-04-11 | vs CHA | 2 | L 0-2 | 0-2 | 7 | 31,008 | Tommy John | Britt Burns | Britt Burns | Tommy John | Salome Barojas | 6 | 9 | -3 |
| 1982-04-12 | @ TEX | 3 | W 10-7 | 1-2 | 6 | 32,563 | Dave Righetti | Frank Tanana | Dave Righetti | Frank Tanana | Shane Rawley | 16 | 16 | 0 |
| 1982-04-13 | @ TEX | 4 | W 6-3 | 2-2 | 3 | 21,697 | Mike Morgan | Rick Honeycutt | Mike Morgan | Rick Honeycutt | Rich Gossage | 22 | 19 | 3 |
| 1982-04-14 | @ TEX | 5 | L 1-4 | 2-3 | 5 | 16,227 | John Pacella | Charlie Hough | Charlie Hough | John Pacella | | 23 | 23 | 0 |
| 1982-04-16 | @ DET | 6 | W 10-2 | 3-3 | 2 | 14,082 | Ron Guidry | Pat Underwood | Ron Guidry | Pat Underwood | | 33 | 25 | 8 |
| 1982-04-17 | @ DET | 7 | L 3-5 | 3-4 | 4 | 12,963 | Tommy John | Jack Morris | Jack Morris | Tommy John | Kevin Saucier | 36 | 30 | 6 |
| 1982-04-18 | @ DET | 8 | L 2-5 | 3-5 | 5 | 23,334 | Dave Righetti | Dan Petry | Dan Petry | Dave Righetti | | 38 | 35 | 3 |
| 1982-04-20 | @ CHA | 9 | W 11-2 | 4-5 | 5 | 11,588 | Mike Morgan | Steve Trout | Mike Morgan | Steve Trout | | 49 | 37 | 12 |
| 1982-04-21 | @ CHA | 10 | W 1-0 | 5-5 | 4 | 13,700 | Ron Guidry | Richard Dotson | Ron Guidry | Richard Dotson | | 50 | 37 | 13 |
| 1982-04-22 | vs DET | 11 | L 1-3 | 5-6 | 5 | 16,059 | Tommy John | Jack Morris | Jack Morris | Tommy John | | 51 | 40 | 11 |
| 1982-04-23 | vs DET | 12 | L 1-9 | 5-7 | 5 | 20,160 | Dave Righetti | Dan Petry | Dan Petry | Dave Righetti | | 52 | 49 | 3 |
| 1982-04-24 | vs DET | 13 | L 2-7 | 5-8 | 5 | 25,585 | Doyle Alexander | Larry Pashnick | Larry Pashnick | Doyle Alexander | Kevin Saucier | 54 | 56 | -2 |
| 1982-04-25 | vs DET | 14 | W 3-1 | 6-8 | 5 | 37,348 | Rudy May | Milt Wilcox | Shane Rawley | Milt Wilcox | Rich Gossage | 57 | 57 | 0 |
| 1982-04-27 | vs CAL | 15 | L 1-3 | 6-9 | 5 | 35,458 | Ron Guidry | Angel Moreno | Angel Moreno | Ron Guidry | | 58 | 60 | -2 |
| 1982-04-28 | vs CAL | 16 | W 6-0 | 7-9 | 5 | 25,498 | Tommy John | Ken Forsch | Tommy John | Ken Forsch | | 64 | 60 | 4 |
| 1982-04-29 | vs CAL | 17 | L 0-2 | 7-10 | 6 | 25,350 | Dave Righetti | Geoff Zahn | Geoff Zahn | Shane Rawley | | 64 | 62 | 2 |
| 1982-04-30 | vs SEA | 18 | L 3-6 | 7-11 | 6 | 20,121 | Doyle Alexander | Gaylord Perry | Gaylord Perry | Rich Gossage | Bill Caudill | 67 | 68 | -1 |
| 1982-05-01 | vs SEA | 19 | W 5-1 | 8-11 | 5 | 20,118 | Mike Morgan | Jim Beattie | George Frazier | Jim Beattie | | 72 | 69 | 3 |
| 1982-05-02 | vs SEA | 20 | W 4-2 | 9-11 | 4 | 35,029 | Ron Guidry | Floyd Bannister | Ron Guidry | Floyd Bannister | Rich Gossage | 76 | 71 | 5 |
| 1982-05-03 | vs OAK | 21 | L 2-5 | 9-12 | 4 | 21,026 | Tommy John | Matt Keough | Matt Keough | Tommy John | | 78 | 76 | 2 |
| 1982-05-04 | vs OAK | 22 | L 7-9 | 9-13 | 5 | 22,414 | Dave Righetti | Tom Underwood | Bob Owchinko | Dave LaRoche | Dave Beard | 85 | 85 | 0 |
| 1982-05-06 | @ SEA | 23 | L 3-7 | 9-14 | 6 | 27,369 | Doyle Alexander | Gaylord Perry | Gaylord Perry | Doyle Alexander | | 88 | 92 | -4 |
| 1982-05-07 | @ SEA | 24 | L 2-5 | 9-15 | 7 | 11,721 | Mike Morgan | Floyd Bannister | Floyd Bannister | Mike Morgan | Bill Caudill | 90 | 97 | -7 |
| 1982-05-08 | @ SEA | 25 | W 9-4 | 10-15 | 7 | 36,716 | Ron Guidry | Jim Beattie | Ron Guidry | Jim Beattie | Rich Gossage | 99 | 101 | -2 |
| 1982-05-09 | @ SEA | 26 | W 3-0 | 11-15 | 6 | 7,577 | Tommy John | Gene Nelson | Tommy John | Gene Nelson | Rich Gossage | 102 | 101 | 1 |
| 1982-05-10 | @ CAL | 27 | L 1-2 | 11-16 | 6 | 32,138 | Rudy May | Geoff Zahn | Geoff Zahn | Rudy May | | 103 | 103 | 0 |
| 1982-05-11 | @ CAL | 28 | W 3-2 | 12-16 | 6 | 37,413 | Dave Righetti | Ken Forsch | Dave Righetti | Ken Forsch | Rich Gossage | 106 | 105 | 1 |
| 1982-05-12 | @ CAL | 29 | W 6-5 | 13-16 | 5 | 41,859 | Mike Morgan | Angel Moreno | Shane Rawley | Angel Moreno | Rich Gossage | 112 | 110 | 2 |
| 1982-05-13 | @ OAK | 30 | W 6-4 | 14-16 | 5 | 24,560 | Ron Guidry | Tom Underwood | Ron Guidry | Tom Underwood | Shane Rawley | 118 | 114 | 4 |
| 1982-05-14 | @ OAK | 31 | W 7-4 | 15-16 | 4 | 33,774 | Tommy John | Matt Keough | Mike Morgan | Matt Keough | Rich Gossage | 125 | 118 | 7 |
| 1982-05-15 | @ OAK | 32 | L 3-7 | 15-17 | 4 | 43,113 | Rudy May | Rick Langford | Rick Langford | Rudy May | | 128 | 125 | 3 |
| 1982-05-16 | @ OAK | 33 | L 6-7 | 15-18 | 4 | 48,137 | Dave Righetti | Steve McCatty | Steve McCatty | Dave Righetti | Dave Beard | 134 | 132 | 2 |
| 1982-05-17 | @ KCA | 34 | L 0-7 | 15-19 | 4 | 38,955 | Roger Erickson | Larry Gura | Larry Gura | Roger Erickson | | 134 | 139 | -5 |
| 1982-05-18 | @ KCA | 35 | W 6-2 | 16-19 | 4 | 28,076 | Ron Guidry | Dave Frost | Ron Guidry | Dave Frost | | 140 | 141 | -1 |
| 1982-05-19 | @ KCA | 36 | W 3-2 | 17-19 | 4 | 26,121 | Tommy John | Paul Splittorff | Tommy John | Paul Splittorff | Rich Gossage | 143 | 143 | 0 |
| 1982-05-21 | vs MIN | 37 | W 12-1 | 18-19 | 4 | 25,106 | Rudy May | Brad Havens | Rudy May | Brad Havens | | 155 | 144 | 11 |
| 1982-05-22 | vs MIN | 38 | W 1-0 | 19-19 | 4 | 20,206 | Dave Righetti | Darrell Jackson | Dave Righetti | Darrell Jackson | Rich Gossage | 156 | 144 | 12 |
| 1982-05-23 | vs MIN | 39 | W 4-2 | 20-19 | 4 | 31,029 | Ron Guidry | Bobby Castillo | Ron Guidry | Bobby Castillo | Rich Gossage | 160 | 146 | 14 |
| 1982-05-25 | vs TOR | 40 | W 8-0 | 21-19 | 3 | 20,127 | Tommy John | Jim Gott | Tommy John | Jim Gott | | 168 | 146 | 22 |
| 1982-05-26 | vs TOR | 41 | L 0-7 | 21-20 | 3 | 15,090 | Rudy May | Dave Stieb | Dave Stieb | Rudy May | | 168 | 153 | 15 |
| 1982-05-28 | @ MIN | 42 | W 10-5 | 22-20 | 3 | 18,854 | Ron Guidry | Bobby Castillo | Rich Gossage | Ron Davis | | 178 | 158 | 20 |
| 1982-05-29 | @ MIN | 43 | W 6-4 | 23-20 | 3 | 18,109 | Tommy John | Terry Felton | Shane Rawley | Brad Havens | | 184 | 162 | 22 |
| 1982-05-30 | @ MIN | 44 | W 8-6 | 24-20 | 3 | 16,352 | Dave Righetti | Albert Williams | Rich Gossage | Paul Boris | Shane Rawley | 192 | 168 | 24 |
| 1982-05-31 | @ TOR | 45 | L 4-5 | 24-21 | 3 | 20,136 | Roger Erickson | Dave Stieb | Dave Stieb | Roger Erickson | | 196 | 173 | 23 |
| 1982-06-01 | @ TOR | 46 | L 2-5 | 24-22 | 3 | 17,460 | Mike Morgan | Jerry Garvin | Dale Murray | Shane Rawley | | 198 | 178 | 20 |
| 1982-06-02 | @ TOR | 47 | W 12-6 | 25-22 | 3 | 20,161 | Ron Guidry | Jim Clancy | Shane Rawley | Joey McLaughlin | | 210 | 184 | 26 |
| 1982-06-03 | @ TOR | 48 | L 1-3 | 25-23 | 4 | 20,147 | Tommy John | Luis Leal | Luis Leal | Tommy John | | 211 | 187 | 24 |
| 1982-06-04 | vs KCA | 49 | L 3-4 | 25-24 | 5 | 25,221 | Dave Righetti | Paul Splittorff | Paul Splittorff | Dave Righetti | Dan Quisenberry | 214 | 191 | 23 |
| 1982-06-06 | vs KCA | 50 | L 1-14 | 25-25 | 5 | 32,068 | Mike Morgan | Vida Blue | Vida Blue | Mike Morgan | | 215 | 205 | 10 |
| 1982-06-08 | @ BOS | 51 | L 3-4 | 25-26 | 6 | 31,413 | Ron Guidry | Dennis Eckersley | Mark Clear | George Frazier | | 218 | 209 | 9 |
| 1982-06-09 | @ BOS | 52 | L 2-3 | 25-27 | 6 | 32,792 | Tommy John | Bruce Hurst | Bruce Hurst | Tommy John | Bob Stanley | 220 | 212 | 8 |
| 1982-06-10 | @ BOS | 53 | W 5-3 | 26-27 | 6 | 33,462 | Dave Righetti | John Tudor | Dave Righetti | John Tudor | Rich Gossage | 225 | 215 | 10 |
| 1982-06-11 | @ BAL | 54 | L 4-9 | 26-28 | 6 | 32,515 | Mike Morgan | Dennis Martinez | Dennis Martinez | Mike Morgan | Tippy Martinez | 229 | 224 | 5 |
| 1982-06-12 | @ BAL | 55 | L 3-5 | 26-29 | 6 | 34,354 | Roger Erickson | Jim Palmer | Tippy Martinez | Shane Rawley | Tim Stoddard | 232 | 229 | 3 |
| 1982-06-14 | vs BOS | 56 | W 5-1 | 27-29 | 6 | 35,159 | Ron Guidry | Dennis Eckersley | Ron Guidry | Dennis Eckersley | | 237 | 230 | 7 |
| 1982-06-15 | vs BOS | 57 | W 5-4 | 28-29 | 6 | 35,559 | Tommy John | Bruce Hurst | Rich Gossage | Mark Clear | | 242 | 234 | 8 |
| 1982-06-16 | vs BOS | 58 | W 4-1 | 29-29 | 5 | 30,267 | Dave Righetti | John Tudor | Dave Righetti | John Tudor | | 246 | 235 | 11 |
| 1982-06-18 | vs BAL | 59 | L 1-4 | 29-30 | 6 | 35,199 | Mike Morgan | Jim Palmer | Jim Palmer | Mike Morgan | Tippy Martinez | 247 | 239 | 8 |
| 1982-06-19 | vs BAL | 60 | W 4-3 | 30-30 | 5 | 35,377 | Ron Guidry | Scott McGregor | Dave LaRoche | Storm Davis | | 251 | 242 | 9 |
| 1982-06-20 | vs BAL | 61 | L 3-5 | 30-31 | 6 | 46,127 | Tommy John | Mike Flanagan | Tippy Martinez | Rich Gossage | | 254 | 247 | 7 |
| 1982-06-21 | @ MIL | 62 | L 2-6 | 30-32 | 6 | 26,895 | Dave Righetti | Bob McClure | Bob McClure | Dave Righetti | Dwight Bernard | 256 | 253 | 3 |
| 1982-06-22 | @ MIL | 63 | L 2-3 | 30-33 | 6 | 31,632 | Roger Erickson | Pete Vuckovich | Pete Vuckovich | Roger Erickson | Rollie Fingers | 258 | 256 | 2 |
| 1982-06-23 | @ MIL | 64 | W 3-2 | 31-33 | 6 | 31,822 | Mike Morgan | Mike Caldwell | Mike Morgan | Mike Caldwell | Rich Gossage | 261 | 258 | 3 |
| 1982-06-24 | vs CLE | 65 | L 2-5 | 31-34 | 6 | 23,449 | Ron Guidry | Rick Sutcliffe | Dan Spillner | Ron Guidry | | 263 | 263 | 0 |
| 1982-06-25 | vs CLE | 66 | W 11-3 | 32-34 | 6 | 21,948 | Tommy John | Len Barker | Tommy John | Len Barker | | 274 | 266 | 8 |
| 1982-06-26 | vs CLE | 67 | W 4-3 | 33-34 | 5 | 21,975 | Dave Righetti | Rick Waits | Dave LaRoche | Ed Whitson | | 278 | 269 | 9 |
| 1982-06-27 | vs CLE | 68 | L 3-4 | 33-35 | 6 | 55,521 | Roger Erickson | Lary Sorensen | Lary Sorensen | Roger Erickson | Rick Sutcliffe | 281 | 273 | 8 |
| 1982-06-29 | vs MIL | 69 | L 4-11 | 33-36 | 6 | 20,199 | Ron Guidry | Mike Caldwell | Mike Caldwell | Ron Guidry | | 285 | 284 | 1 |
| 1982-06-30 | vs MIL | 70 | L 7-9 | 33-37 | 6 | 20,815 | Tommy John | Randy Lerch | Rollie Fingers | Shane Rawley | Jamie Easterly | 292 | 293 | -1 |
| 1982-07-01 | vs MIL | 71 | W 5-3 | 34-37 | 6 | 20,116 | Mike Morgan | Moose Haas | Mike Morgan | Moose Haas | | 297 | 296 | 1 |
| 1982-07-02 | @ CLE | 72 | W 3-1 | 35-37 | 6 | 31,735 | Roger Erickson | Rick Waits | Roger Erickson | Rick Waits | Rich Gossage | 300 | 297 | 3 |
| 1982-07-03 | @ CLE | 73 | W 10-6 | 36-37 | 6 | 69,557 | Tommy John | Lary Sorensen | George Frazier | Dan Spillner | Rich Gossage | 310 | 303 | 7 |
| 1982-07-04 | @ CLE | 74 | W 3-2 | 37-37 | 5 | 22,652 | Ron Guidry | John Denny | George Frazier | John Denny | Roger Erickson | 313 | 305 | 8 |
| 1982-07-05 | @ SEA | 75 | L 4-5 | 37-38 | 5 | 36,471 | Shane Rawley | Jim Beattie | Ed Vande Berg | George Frazier | Bill Caudill | 317 | 310 | 7 |
| 1982-07-06 | @ SEA | 76 | W 8-7 | 38-38 | 5 | 26,002 | Mike Morgan | Gaylord Perry | Rudy May | Ed Vande Berg | | 325 | 317 | 8 |
| 1982-07-07 | @ OAK | 77 | W 5-3 | 39-38 | 5 | 26,269 | Roger Erickson | Rick Langford | Roger Erickson | Rick Langford | Rich Gossage | 330 | 320 | 10 |
| 1982-07-08 | @ OAK | 78 | L 3-6 | 39-39 | 5 | 27,352 | Doyle Alexander | Mike Norris | Mike Norris | Doyle Alexander | | 333 | 326 | 7 |
| 1982-07-09 | @ CAL | 79 | L 1-4 | 39-40 | 5 | 41,111 | Tommy John | Geoff Zahn | Geoff Zahn | Tommy John | | 334 | 330 | 4 |
| 1982-07-10 | @ CAL | 80 | L 6-12 | 39-41 | 6 | 53,851 | Ron Guidry | Ken Forsch | Ken Forsch | Ron Guidry | Andy Hassler | 340 | 342 | -2 |
| 1982-07-11 | @ CAL | 81 | L 1-2 | 39-42 | 6 | 44,834 | Shane Rawley | Steve Renko | Andy Hassler | Rich Gossage | Don Aase | 341 | 344 | -3 |
| 1982-07-15 | vs OAK | 82 | W 2-1 | 40-42 | 6 | 30,267 | Mike Morgan | Mike Norris | Rich Gossage | Dave Beard | | 343 | 345 | -2 |
| 1982-07-16 | vs OAK | 83 | W 6-2 | 41-42 | 5 | 30,872 | Roger Erickson | Rick Langford | Roger Erickson | Rick Langford | | 349 | 347 | 2 |
| 1982-07-17 | vs OAK | 84 | W 4-1 | 42-42 | 5 | 38,590 | Shane Rawley | Matt Keough | Shane Rawley | Matt Keough | | 353 | 348 | 5 |
| 1982-07-18 | vs OAK | 85 | W 7-3 | 43-42 | 5 | 38,184 | Ron Guidry | Brian Kingman | Ron Guidry | Brian Kingman | | 360 | 351 | 9 |
| 1982-07-19 | vs SEA | 86 | W 5-3 | 44-42 | 5 | 16,408 | Tommy John | Gene Nelson | Tommy John | Gene Nelson | Rich Gossage | 365 | 354 | 11 |
| 1982-07-20 | vs SEA | 87 | L 5-6 | 44-43 | 5 | 20,321 | Dave Righetti | Jim Beattie | Bill Caudill | Shane Rawley | | 370 | 360 | 10 |
| 1982-07-21 | vs SEA | 88 | L 5-6 | 44-44 | 5 | 23,531 | Mike Morgan | Floyd Bannister | Bill Caudill | George Frazier | | 375 | 366 | 9 |
| 1982-07-22 | vs TEX | 89 | W 4-3 | 45-44 | 5 | 14,626 | Roger Erickson | John Butcher | Roger Erickson | John Butcher | Rudy May | 379 | 369 | 10 |
| 1982-07-23 | vs CAL | 90 | W 6-3 | 46-44 | 4 | 50,314 | Shane Rawley | Geoff Zahn | Shane Rawley | Geoff Zahn | Dave Righetti | 385 | 372 | 13 |
| 1982-07-24 | vs CAL | 91 | W 6-5 | 47-44 | 4 | 47,917 | Ron Guidry | Steve Renko | Rudy May | Bruce Kison | | 391 | 377 | 14 |
| 1982-07-25 | vs CAL | 92 | L 4-6 | 47-45 | 5 | 51,561 | Tommy John | Dave Goltz | Mickey Mahler | Tommy John | | 395 | 383 | 12 |
| 1982-07-26 | vs DET | 93 | L 3-5 | 47-46 | 5 | 21,021 | Mike Morgan | Jerry Ujdur | Jerry Ujdur | Mike Morgan | Dave Gumpert | 398 | 388 | 10 |
| 1982-07-27 | vs DET | 94 | W 6-5 | 48-46 | 5 | 22,966 | Roger Erickson | Jack Morris | Rudy May | Jack Morris | Rich Gossage | 404 | 393 | 11 |
| 1982-07-28 | vs DET | 95 | W 8-7 | 49-46 | 5 | 16,521 | Shane Rawley | Larry Pashnick | George Frazier | Bob James | Rich Gossage | 412 | 400 | 12 |
| 1982-07-30 | @ TEX | 96 | W 4-0 | 50-46 | 4 | 23,355 | Ron Guidry | Doc Medich | Ron Guidry | Doc Medich | Rudy May | 416 | 400 | 16 |
| 1982-07-31 | @ TEX | 97 | L 2-3 | 50-47 | 4 | 32,924 | Doyle Alexander | Charlie Hough | Charlie Hough | Doyle Alexander | Danny Darwin | 418 | 403 | 15 |
| 1982-08-01 | @ TEX | 98 | L 2-4 | 50-48 | 5 | 18,905 | Mike Morgan | Rick Honeycutt | Rick Honeycutt | Mike Morgan | Jon Matlack | 420 | 407 | 13 |
| 1982-08-03 | vs CHA | 99 | L 0-1 | 50-50 | 6 | 0 | Shane Rawley | Steve Trout | Steve Trout | Shane Rawley | Dennis Lamp | 420 | 408 | 12 |
| 1982-08-03 | vs CHA | 100 | L 2-14 | 50-50 | 6 | 34,172 | Roger Erickson | Richard Dotson | Richard Dotson | Roger Erickson | Rich Barnes | 422 | 422 | 0 |
| 1982-08-04 | vs CHA | 101 | W 6-2 | 51-51 | 6 | 0 | Ron Guidry | LaMarr Hoyt | Ron Guidry | LaMarr Hoyt | Rich Gossage | 428 | 424 | 4 |
| 1982-08-04 | vs CHA | 102 | L 0-7 | 51-51 | 6 | 26,218 | Tommy John | Britt Burns | Britt Burns | Tommy John | | 428 | 431 | -3 |
| 1982-08-05 | vs TEX | 103 | L 2-7 | 51-52 | 6 | 18,449 | Doyle Alexander | Charlie Hough | Charlie Hough | Doyle Alexander | | 430 | 438 | -8 |
| 1982-08-06 | vs TEX | 104 | W 6-0 | 52-52 | 6 | 21,469 | Dave Righetti | Rick Honeycutt | Dave Righetti | Rick Honeycutt | | 436 | 438 | -2 |
| 1982-08-07 | vs TEX | 105 | W 9-1 | 53-52 | 5 | 43,248 | Mike Morgan | Frank Tanana | Mike Morgan | Frank Tanana | | 445 | 439 | 6 |
| 1982-08-08 | vs TEX | 106 | L 4-6 | 54-53 | 5 | 0 | Shane Rawley | John Butcher | Danny Darwin | Shane Rawley | | 449 | 445 | 4 |
| 1982-08-08 | vs TEX | 107 | W 8-5 | 54-53 | 5 | 33,421 | Tommy John | Dave J. Schmidt | Tommy John | Dave J. Schmidt | Rich Gossage | 457 | 450 | 7 |
| 1982-08-09 | @ DET | 108 | W 9-7 | 55-53 | 4 | 30,992 | Ron Guidry | Dan Petry | Dave LaRoche | Dave Rucker | Rich Gossage | 466 | 457 | 9 |
| 1982-08-10 | @ DET | 109 | L 1-10 | 55-54 | 5 | 26,122 | Doyle Alexander | Jerry Ujdur | Jerry Ujdur | Doyle Alexander | | 467 | 467 | 0 |
| 1982-08-11 | @ DET | 110 | L 2-3 | 55-55 | 5 | 27,677 | Dave Righetti | Jack Morris | Dave Tobik | George Frazier | | 469 | 470 | -1 |
| 1982-08-12 | @ CHA | 111 | L 1-2 | 55-56 | 5 | 25,033 | Mike Morgan | Jerry Koosman | Jerry Koosman | Mike Morgan | | 470 | 472 | -2 |
| 1982-08-13 | @ CHA | 112 | W 4-3 | 56-56 | 5 | 34,806 | Tommy John | Steve Trout | Tommy John | Steve Trout | Rich Gossage | 474 | 475 | -1 |
| 1982-08-14 | @ CHA | 113 | L 0-6 | 56-57 | 5 | 41,431 | Shane Rawley | LaMarr Hoyt | LaMarr Hoyt | Shane Rawley | | 474 | 481 | -7 |
| 1982-08-15 | @ CHA | 114 | L 4-6 | 56-58 | 5 | 31,160 | Ron Guidry | Britt Burns | Dennis Lamp | Rich Gossage | | 478 | 487 | -9 |
| 1982-08-16 | vs KCA | 115 | W 2-0 | 58-58 | 5 | 0 | Dave Righetti | Vida Blue | Dave Righetti | Vida Blue | Rich Gossage | 480 | 487 | -7 |
| 1982-08-16 | vs KCA | 116 | W 4-3 | 58-58 | 5 | 26,815 | Rudy May | Buddy Black | Rudy May | Buddy Black | Rich Gossage | 484 | 490 | -6 |
| 1982-08-17 | vs KCA | 117 | L 4-8 | 58-59 | 5 | 24,532 | Mike Morgan | Paul Splittorff | Paul Splittorff | Mike Morgan | Don Hood | 488 | 498 | -10 |
| 1982-08-18 | vs KCA | 118 | W 9-2 | 59-59 | 5 | 22,604 | Tommy John | Dave Frost | Tommy John | Dave Frost | | 497 | 500 | -3 |
| 1982-08-20 | vs TOR | 119 | W 4-2 | 60-59 | 5 | 20,172 | Shane Rawley | Dave Stieb | Shane Rawley | Dave Stieb | Rich Gossage | 501 | 502 | -1 |
| 1982-08-21 | vs TOR | 120 | L 1-3 | 60-60 | 5 | 24,029 | Ron Guidry | Jim Clancy | Jim Clancy | Ron Guidry | Dale Murray | 502 | 505 | -3 |
| 1982-08-22 | vs TOR | 121 | W 3-1 | 61-60 | 5 | 33,692 | Dave Righetti | Jim Gott | Dave Righetti | Jim Gott | Rich Gossage | 505 | 506 | -1 |
| 1982-08-23 | vs TOR | 122 | W 4-3 | 62-60 | 5 | 16,565 | Mike Morgan | Luis Leal | Dave LaRoche | Luis Leal | Rich Gossage | 509 | 509 | 0 |
| 1982-08-24 | vs MIN | 123 | L 0-5 | 62-61 | 5 | 17,438 | Tommy John | Frank Viola | Frank Viola | Tommy John | | 509 | 514 | -5 |
| 1982-08-25 | vs MIN | 124 | W 8-1 | 63-61 | 5 | 18,440 | Shane Rawley | Bobby Castillo | Shane Rawley | Bobby Castillo | | 517 | 515 | 2 |
| 1982-08-26 | vs MIN | 125 | W 7-2 | 64-61 | 4 | 24,252 | Ron Guidry | Brad Havens | Ron Guidry | Brad Havens | | 524 | 517 | 7 |
| 1982-08-27 | @ TOR | 126 | L 3-10 | 64-62 | 5 | 28,438 | Dave Righetti | Luis Leal | Luis Leal | Dave Righetti | | 527 | 527 | 0 |
| 1982-08-28 | @ TOR | 127 | L 2-3 | 64-63 | 5 | 35,065 | Mike Morgan | Dave Stieb | Dale Murray | Dave LaRoche | | 529 | 530 | -1 |
| 1982-08-29 | @ TOR | 128 | W 8-2 | 65-63 | 5 | 34,313 | Tommy John | Jim Clancy | Tommy John | Jim Clancy | | 537 | 532 | 5 |
| 1982-08-30 | @ MIN | 129 | W 8-2 | 66-63 | 5 | 11,325 | Shane Rawley | Frank Viola | Shane Rawley | Frank Viola | | 545 | 534 | 11 |
| 1982-08-31 | @ MIN | 130 | W 3-1 | 67-63 | 4 | 11,355 | Ron Guidry | Brad Havens | Ron Guidry | Brad Havens | | 548 | 535 | 13 |
| 1982-09-01 | @ MIN | 131 | L 2-7 | 67-64 | 5 | 9,829 | Dave Righetti | Albert Williams | Albert Williams | Dave Righetti | | 550 | 542 | 8 |
| 1982-09-03 | @ KCA | 132 | L 3-5 | 67-65 | 5 | 33,613 | Jay Howell | Vida Blue | Vida Blue | Jay Howell | Dan Quisenberry | 553 | 547 | 6 |
| 1982-09-04 | @ KCA | 133 | W 3-2 | 68-65 | 5 | 37,881 | Shane Rawley | Larry Gura | Shane Rawley | Larry Gura | Rudy May | 556 | 549 | 7 |
| 1982-09-05 | @ KCA | 134 | W 18-7 | 69-65 | 5 | 40,801 | Ron Guidry | Dennis Leonard | Ron Guidry | Dennis Leonard | | 574 | 556 | 18 |
| 1982-09-06 | vs BAL | 135 | L 2-8 | 69-66 | 5 | 32,537 | Dave Righetti | Scott McGregor | Scott McGregor | Dave Righetti | Sammy Stewart | 576 | 564 | 12 |
| 1982-09-07 | vs BAL | 136 | L 2-7 | 69-67 | 5 | 15,405 | Mike Morgan | Mike Flanagan | Mike Flanagan | Mike Morgan | | 578 | 571 | 7 |
| 1982-09-08 | vs BAL | 137 | W 10-5 | 70-67 | 5 | 20,898 | Jay Howell | Jim Palmer | Jay Howell | Jim Palmer | | 588 | 576 | 12 |
| 1982-09-09 | vs MIL | 138 | W 5-4 | 71-67 | 5 | 21,392 | Shane Rawley | Pete Vuckovich | Rudy May | Pete Ladd | | 593 | 580 | 13 |
| 1982-09-10 | vs MIL | 139 | L 3-5 | 71-68 | 5 | 26,592 | Ron Guidry | Mike Caldwell | Mike Caldwell | Ron Guidry | | 596 | 585 | 11 |
| 1982-09-11 | vs MIL | 140 | W 14-2 | 72-68 | 5 | 25,011 | Dave Righetti | Doc Medich | Dave Righetti | Doc Medich | | 610 | 587 | 23 |
| 1982-09-12 | vs MIL | 141 | W 9-8 | 73-68 | 4 | 38,252 | Doyle Alexander | Don Sutton | Curt Kaufman | Jamie Easterly | | 619 | 595 | 24 |
| 1982-09-13 | @ BAL | 142 | L 7-8 | 73-69 | 5 | 18,892 | Jay Howell | Dennis Martinez | Mike Boddicker | Rudy May | Tippy Martinez | 626 | 603 | 23 |
| 1982-09-14 | @ BAL | 143 | L 4-5 | 73-71 | 5 | 0 | Shane Rawley | Scott McGregor | John Flinn | Shane Rawley | Tippy Martinez | 630 | 608 | 22 |
| 1982-09-14 | @ BAL | 144 | L 3-5 | 73-71 | 5 | 28,094 | Mike Morgan | Storm Davis | Storm Davis | Mike Morgan | Tippy Martinez | 633 | 613 | 20 |
| 1982-09-15 | @ BAL | 145 | L 5-8 | 73-72 | 5 | 22,861 | Ron Guidry | Mike Flanagan | Don Welchel | Ron Guidry | Sammy Stewart | 638 | 621 | 17 |
| 1982-09-16 | @ BAL | 146 | L 1-3 | 73-73 | 5 | 25,089 | Dave Righetti | Jim Palmer | Jim Palmer | Dave Righetti | | 639 | 624 | 15 |
| 1982-09-17 | @ MIL | 147 | L 0-14 | 73-74 | 5 | 20,144 | Stefan Wever | Mike Caldwell | Mike Caldwell | Stefan Wever | | 639 | 638 | 1 |
| 1982-09-18 | @ MIL | 148 | L 4-6 | 73-75 | 5 | 38,719 | Jay Howell | Bob McClure | Bob McClure | Jay Howell | Dwight Bernard | 643 | 644 | -1 |
| 1982-09-19 | @ MIL | 149 | L 1-14 | 73-76 | 5 | 30,306 | Shane Rawley | Don Sutton | Don Sutton | Shane Rawley | | 644 | 658 | -14 |
| 1982-09-21 | vs CLE | 150 | L 8-9 | 74-77 | 5 | 0 | Ron Guidry | Len Barker | Jerry Reed | Rudy May | Ed Glynn | 652 | 667 | -15 |
| 1982-09-21 | vs CLE | 151 | W 6-2 | 74-77 | 5 | 15,339 | Dave Righetti | Lary Sorensen | Dave Righetti | Lary Sorensen | | 658 | 669 | -11 |
| 1982-09-22 | vs CLE | 152 | L 0-5 | 74-78 | 6 | 16,922 | Doyle Alexander | Rick Sutcliffe | Rick Sutcliffe | Doyle Alexander | | 658 | 674 | -16 |
| 1982-09-24 | @ BOS | 153 | L 2-4 | 74-79 | 6 | 32,077 | Jay Howell | John Tudor | John Tudor | Jay Howell | | 660 | 678 | -18 |
| 1982-09-25 | @ BOS | 154 | W 6-2 | 75-79 | 6 | 33,559 | Shane Rawley | Dennis Eckersley | Shane Rawley | Dennis Eckersley | | 666 | 680 | -14 |
| 1982-09-26 | @ BOS | 155 | L 2-5 | 75-80 | 6 | 32,793 | Ron Guidry | Mike Torrez | Bob Stanley | Ron Guidry | | 668 | 685 | -17 |
| 1982-09-27 | @ BOS | 156 | W 10-3 | 76-80 | 6 | 21,359 | Dave Righetti | Brian Denman | Dave Righetti | Brian Denman | | 678 | 688 | -10 |
| 1982-09-28 | @ CLE | 157 | W 6-4 | 77-80 | 5 | 5,017 | Doyle Alexander | Rick Sutcliffe | Doyle Alexander | Rick Sutcliffe | Rich Gossage | 684 | 692 | -8 |
| 1982-09-29 | @ CLE | 158 | W 13-6 | 78-80 | 5 | 6,868 | Jay Howell | Lary Sorensen | Jay Howell | Lary Sorensen | George Frazier | 697 | 698 | -1 |
| 1982-09-30 | @ CLE | 159 | W 7-5 | 79-80 | 5 | 6,358 | Shane Rawley | Neal Heaton | Mike Morgan | Dan Spillner | Rich Gossage | 704 | 703 | 1 |
| 1982-10-01 | vs BOS | 160 | L 2-3 | 79-81 | 5 | 26,142 | Ron Guidry | Mike Torrez | Steve Crawford | Mike Morgan | | 706 | 706 | 0 |
| 1982-10-02 | vs BOS | 161 | L 0-5 | 79-82 | 5 | 36,917 | Dave Righetti | Brian Denman | Brian Denman | Dave Righetti | | 706 | 711 | -5 |
| 1982-10-03 | vs BOS | 162 | L 3-5 | 79-83 | 5 | 31,465 | Doyle Alexander | Bruce Hurst | Mike Brown | Rudy May | | 709 | 716 | -7 |