| 1982-04-08 | @ PHI | 1 | W 7-2 | 1-0 | 1 | 15,345 | Randy Jones | Steve Carlton | Randy Jones | Steve Carlton | | 7 | 2 | 5 |
| 1982-04-09 | @ CHN | 2 | L 0-5 | 1-1 | 3 | 26,712 | Mike Scott | Fergie Jenkins | Fergie Jenkins | Mike Scott | Lee Smith | 7 | 7 | 0 |
| 1982-04-10 | @ CHN | 3 | W 9-5 | 2-1 | 3 | 8,019 | Pat Zachry | Doug Bird | Pat Zachry | Doug Bird | | 16 | 12 | 4 |
| 1982-04-11 | @ CHN | 4 | W 5-4 | 3-1 | 1 | 5,430 | Pete Falcone | Dan Larson | Pete Falcone | Dan Larson | Neil Allen | 21 | 16 | 5 |
| 1982-04-12 | @ CHN | 5 | L 4-5 | 3-2 | 2 | 6,866 | Craig Swan | Dickie Noles | Dickie Noles | Craig Swan | Bill Campbell | 25 | 21 | 4 |
| 1982-04-13 | vs PHI | 6 | W 5-2 | 4-2 | 2 | 40,845 | Randy Jones | Steve Carlton | Randy Jones | Steve Carlton | Neil Allen | 30 | 23 | 7 |
| 1982-04-14 | vs PHI | 7 | W 8-1 | 5-2 | 2 | 13,420 | Mike Scott | Dick Ruthven | Mike Scott | Dick Ruthven | | 38 | 24 | 14 |
| 1982-04-15 | vs PHI | 8 | L 4-8 | 5-3 | 2 | 14,634 | Pat Zachry | Larry Christenson | Warren Brusstar | Charlie Puleo | | 42 | 32 | 10 |
| 1982-04-16 | vs MON | 9 | L 3-4 | 5-4 | 3 | 20,587 | Pete Falcone | Bill Gullickson | Jeff Reardon | Jesse Orosco | | 45 | 36 | 9 |
| 1982-04-17 | vs MON | 10 | W 2-1 | 6-4 | 2 | 16,529 | Craig Swan | Ray Burris | Charlie Puleo | Ray Burris | Ed Lynch | 47 | 37 | 10 |
| 1982-04-18 | vs MON | 11 | L 6-7 | 6-5 | 3 | 27,159 | Randy Jones | Charlie Lea | Charlie Lea | Randy Jones | Jeff Reardon | 53 | 44 | 9 |
| 1982-04-20 | vs CHN | 12 | W 3-2 | 7-5 | 2 | 8,226 | Mike Scott | Doug Bird | Mike Scott | Doug Bird | Neil Allen | 56 | 46 | 10 |
| 1982-04-21 | vs CHN | 13 | W 7-4 | 8-5 | 2 | 8,815 | Pat Zachry | Dan Larson | Craig Swan | Bill Campbell | Neil Allen | 63 | 50 | 13 |
| 1982-04-23 | @ MON | 14 | L 4-5 | 8-6 | 3 | 15,470 | Randy Jones | Bill Gullickson | Jeff Reardon | Jesse Orosco | | 67 | 55 | 12 |
| 1982-04-24 | @ MON | 15 | W 1-0 | 9-6 | 2 | 30,559 | Charlie Puleo | Ray Burris | Charlie Puleo | Ray Burris | Neil Allen | 68 | 55 | 13 |
| 1982-04-25 | @ MON | 16 | L 2-5 | 9-7 | 3 | 34,781 | Mike Scott | Scott Sanderson | Scott Sanderson | Mike Scott | Jeff Reardon | 70 | 60 | 10 |
| 1982-04-27 | @ SDN | 17 | L 5-8 | 9-8 | 3 | 20,414 | Pat Zachry | John Curtis | Eric Show | Jesse Orosco | | 75 | 68 | 7 |
| 1982-04-28 | @ SDN | 18 | W 5-4 | 10-8 | 3 | 23,315 | Randy Jones | John Montefusco | Pete Falcone | Gary Lucas | | 80 | 72 | 8 |
| 1982-04-29 | @ SDN | 19 | L 0-6 | 10-9 | 3 | 19,691 | Charlie Puleo | Tim Lollar | Tim Lollar | Charlie Puleo | | 80 | 78 | 2 |
| 1982-04-30 | @ SFN | 20 | L 4-5 | 10-10 | 3 | 5,961 | Mike Scott | Rich Gale | Fred Breining | Neil Allen | | 84 | 83 | 1 |
| 1982-05-01 | @ SFN | 21 | L 3-6 | 10-11 | 3 | 6,466 | Pat Zachry | Atlee Hammaker | Atlee Hammaker | Pat Zachry | Greg Minton | 87 | 89 | -2 |
| 1982-05-02 | @ SFN | 22 | L 3-4 | 11-12 | 3 | 0 | Ed Lynch | Al Holland | Al Holland | Ed Lynch | Greg Minton | 90 | 93 | -3 |
| 1982-05-02 | @ SFN | 23 | W 2-0 | 11-12 | 3 | 20,543 | Randy Jones | Bill Laskey | Randy Jones | Bill Laskey | Neil Allen | 92 | 93 | -1 |
| 1982-05-03 | @ LAN | 24 | W 6-3 | 12-12 | 3 | 33,349 | Charlie Puleo | Burt Hooton | Ed Lynch | Terry Forster | | 98 | 96 | 2 |
| 1982-05-04 | @ LAN | 25 | L 1-2 | 12-13 | 3 | 36,718 | Mike Scott | Fernando Valenzuela | Fernando Valenzuela | Neil Allen | | 99 | 98 | 1 |
| 1982-05-06 | vs SFN | 26 | L 3-5 | 12-14 | 3 | 10,013 | Randy Jones | Atlee Hammaker | Greg Minton | Jesse Orosco | | 102 | 103 | -1 |
| 1982-05-07 | vs SFN | 27 | W 3-2 | 13-14 | 3 | 16,782 | Charlie Puleo | Bill Laskey | Charlie Puleo | Bill Laskey | Neil Allen | 105 | 105 | 0 |
| 1982-05-08 | vs SFN | 28 | L 3-8 | 13-15 | 3 | 17,448 | Mike Scott | Al Holland | Gary Lavelle | Ed Lynch | | 108 | 113 | -5 |
| 1982-05-09 | vs SFN | 29 | W 6-5 | 14-15 | 2 | 15,008 | Pete Falcone | Alan Fowlkes | Craig Swan | Greg Minton | | 114 | 118 | -4 |
| 1982-05-10 | vs SDN | 30 | W 3-2 | 15-15 | 3 | 9,670 | Randy Jones | Chris Welsh | Randy Jones | Gary Lucas | | 117 | 120 | -3 |
| 1982-05-11 | vs SDN | 31 | W 6-0 | 16-15 | 2 | 9,924 | Charlie Puleo | Juan Eichelberger | Charlie Puleo | Juan Eichelberger | | 123 | 120 | 3 |
| 1982-05-13 | vs LAN | 32 | W 4-2 | 17-15 | 2 | 18,013 | Pete Falcone | Burt Hooton | Pete Falcone | Burt Hooton | Neil Allen | 127 | 122 | 5 |
| 1982-05-14 | vs LAN | 33 | L 1-4 | 17-16 | 3 | 50,360 | Randy Jones | Fernando Valenzuela | Fernando Valenzuela | Randy Jones | | 128 | 126 | 2 |
| 1982-05-15 | vs LAN | 34 | W 6-4 | 18-16 | 3 | 29,235 | Charlie Puleo | Ted Power | Pat Zachry | Ted Power | Neil Allen | 134 | 130 | 4 |
| 1982-05-16 | vs LAN | 35 | W 13-4 | 19-16 | 3 | 32,562 | Mike Scott | Jerry Reuss | Mike Scott | Jerry Reuss | | 147 | 134 | 13 |
| 1982-05-17 | vs CIN | 36 | L 2-7 | 19-17 | 3 | 14,131 | Pete Falcone | Charlie Leibrandt | Charlie Leibrandt | Pete Falcone | | 149 | 141 | 8 |
| 1982-05-18 | vs CIN | 37 | W 7-4 | 20-17 | 2 | 15,303 | Randy Jones | Bruce Berenyi | Randy Jones | Bruce Berenyi | Neil Allen | 156 | 145 | 11 |
| 1982-05-19 | vs CIN | 38 | W 4-2 | 21-17 | 2 | 16,790 | Pat Zachry | Tom Seaver | Pat Zachry | Tom Seaver | | 160 | 147 | 13 |
| 1982-05-21 | @ HOU | 39 | L 1-5 | 21-18 | 2 | 22,383 | Mike Scott | Don Sutton | Don Sutton | Mike Scott | | 161 | 152 | 9 |
| 1982-05-22 | @ HOU | 40 | W 6-5 | 22-18 | 2 | 33,253 | Pete Falcone | Nolan Ryan | Neil Allen | Randy Moffitt | | 167 | 157 | 10 |
| 1982-05-23 | @ HOU | 41 | W 2-0 | 23-18 | 2 | 26,624 | Randy Jones | Joe Niekro | Randy Jones | Joe Niekro | | 169 | 157 | 12 |
| 1982-05-24 | @ ATL | 42 | W 5-3 | 24-18 | 2 | 10,388 | Pat Zachry | Ken Dayley | Pat Zachry | Ken Dayley | Neil Allen | 174 | 160 | 14 |
| 1982-05-25 | @ ATL | 43 | L 2-10 | 24-19 | 2 | 9,581 | Mike Scott | Rick Mahler | Rick Mahler | Mike Scott | | 176 | 170 | 6 |
| 1982-05-26 | @ ATL | 44 | W 6-4 | 25-19 | 2 | 12,460 | Pete Falcone | Preston Hanna | Craig Swan | Rick Camp | Neil Allen | 182 | 174 | 8 |
| 1982-05-28 | vs HOU | 45 | L 3-8 | 25-20 | 2 | 15,273 | Randy Jones | Nolan Ryan | Nolan Ryan | Randy Jones | Dave Smith | 185 | 182 | 3 |
| 1982-05-29 | vs HOU | 46 | L 2-5 | 25-21 | 3 | 34,184 | Pat Zachry | Joe Niekro | Joe Niekro | Pat Zachry | | 187 | 187 | 0 |
| 1982-05-30 | vs HOU | 47 | W 9-5 | 26-21 | 2 | 19,544 | Mike Scott | Bob Knepper | Mike Scott | Bob Knepper | Neil Allen | 196 | 192 | 4 |
| 1982-05-31 | vs ATL | 48 | W 10-4 | 27-21 | 2 | 21,954 | Charlie Puleo | Bob Walk | Charlie Puleo | Bob Walk | | 206 | 196 | 10 |
| 1982-06-01 | vs ATL | 49 | L 3-7 | 27-22 | 3 | 9,367 | Randy Jones | Ken Dayley | Ken Dayley | Randy Jones | | 209 | 203 | 6 |
| 1982-06-02 | vs ATL | 50 | L 1-3 | 27-23 | 4 | 18,652 | Pete Falcone | Phil Niekro | Phil Niekro | Pete Falcone | Steve Bedrosian | 210 | 206 | 4 |
| 1982-06-04 | @ CIN | 51 | L 3-8 | 27-24 | 4 | 13,319 | Mike Scott | Tom Seaver | Tom Seaver | Mike Scott | | 213 | 214 | -1 |
| 1982-06-05 | @ CIN | 52 | L 2-6 | 27-25 | 4 | 20,286 | Charlie Puleo | Mario Soto | Mario Soto | Charlie Puleo | | 215 | 220 | -5 |
| 1982-06-06 | @ CIN | 53 | W 6-3 | 28-25 | 4 | 24,053 | Craig Swan | Frank Pastore | Craig Swan | Frank Pastore | Neil Allen | 221 | 223 | -2 |
| 1982-06-07 | vs PIT | 54 | L 3-4 | 28-26 | 4 | 8,791 | Pete Falcone | Manny Sarmiento | Rod Scurry | Neil Allen | | 224 | 227 | -3 |
| 1982-06-08 | vs PIT | 55 | L 2-6 | 28-27 | 4 | 11,774 | Jesse Orosco | Don Robinson | Don Robinson | Jesse Orosco | Kent Tekulve | 226 | 233 | -7 |
| 1982-06-09 | vs PIT | 56 | W 3-2 | 29-27 | 4 | 11,552 | Charlie Puleo | Rick Rhoden | Neil Allen | Kent Tekulve | | 229 | 235 | -6 |
| 1982-06-11 | vs SLN | 57 | L 3-7 | 29-28 | 4 | 23,919 | Randy Jones | Joaquin Andujar | Joaquin Andujar | Randy Jones | | 232 | 242 | -10 |
| 1982-06-12 | vs SLN | 58 | W 6-2 | 30-28 | 4 | 43,675 | Craig Swan | Steve Mura | Craig Swan | Steve Mura | | 238 | 244 | -6 |
| 1982-06-14 | @ PIT | 59 | W 2-1 | 31-28 | 4 | 7,005 | Pete Falcone | Don Robinson | Pete Falcone | Don Robinson | Neil Allen | 240 | 245 | -5 |
| 1982-06-15 | @ PIT | 60 | L 3-13 | 31-29 | 4 | 6,100 | Charlie Puleo | Rick Rhoden | Rick Rhoden | Charlie Puleo | | 243 | 258 | -15 |
| 1982-06-18 | @ SLN | 61 | W 5-3 | 32-30 | 4 | 0 | Craig Swan | Steve Mura | Jesse Orosco | Bruce Sutter | Mike Scott | 248 | 261 | -13 |
| 1982-06-18 | @ SLN | 62 | L 4-5 | 32-30 | 4 | 37,351 | Randy Jones | John Stuper | John Stuper | Ed Lynch | Doug Bair | 252 | 266 | -14 |
| 1982-06-19 | @ SLN | 63 | W 8-5 | 33-30 | 4 | 33,354 | Pete Falcone | Bob Forsch | Tom Hausman | Jeff Keener | Mike Scott | 260 | 271 | -11 |
| 1982-06-20 | @ SLN | 64 | W 5-4 | 34-30 | 3 | 26,926 | Charlie Puleo | Joaquin Andujar | Mike Scott | Bruce Sutter | Ed Lynch | 265 | 275 | -10 |
| 1982-06-21 | vs MON | 65 | L 1-5 | 34-31 | 3 | 20,474 | Pete Falcone | Charlie Lea | Charlie Lea | Pete Falcone | Ray Burris | 266 | 280 | -14 |
| 1982-06-22 | vs MON | 66 | L 3-4 | 34-32 | 3 | 16,850 | Randy Jones | David Palmer | David Palmer | Randy Jones | Jeff Reardon | 269 | 284 | -15 |
| 1982-06-23 | vs MON | 67 | L 0-5 | 34-33 | 4 | 18,852 | Craig Swan | Steve Rogers | Steve Rogers | Craig Swan | | 269 | 289 | -20 |
| 1982-06-24 | vs MON | 68 | W 3-1 | 35-33 | 4 | 18,419 | Charlie Puleo | Bill Gullickson | Charlie Puleo | Bill Gullickson | Mike Scott | 272 | 290 | -18 |
| 1982-06-25 | @ PHI | 69 | L 0-1 | 35-35 | 4 | 0 | Pete Falcone | Dick Ruthven | Dick Ruthven | Pete Falcone | | 272 | 291 | -19 |
| 1982-06-25 | @ PHI | 70 | L 3-5 | 35-35 | 4 | 36,775 | Pat Zachry | Ed Farmer | Ed Farmer | Pat Zachry | Tug McGraw | 275 | 296 | -21 |
| 1982-06-26 | @ PHI | 71 | L 3-4 | 35-37 | 5 | 0 | Randy Jones | Marty Bystrom | Marty Bystrom | Randy Jones | | 278 | 300 | -22 |
| 1982-06-26 | @ PHI | 72 | L 4-7 | 35-37 | 5 | 45,513 | Mike Scott | Larry Christenson | Tug McGraw | Neil Allen | | 282 | 307 | -25 |
| 1982-06-27 | @ PHI | 73 | L 3-8 | 35-38 | 5 | 43,134 | Craig Swan | Mike Krukow | Mike Krukow | Craig Swan | | 285 | 315 | -30 |
| 1982-06-29 | @ MON | 74 | W 5-4 | 36-38 | 4 | 29,194 | Charlie Puleo | Steve Rogers | Terry Leach | Ray Burris | | 290 | 319 | -29 |
| 1982-06-30 | @ MON | 75 | L 1-4 | 36-39 | 5 | 22,385 | Pete Falcone | Bill Gullickson | Bill Gullickson | Pete Falcone | Jeff Reardon | 291 | 323 | -32 |
| 1982-07-01 | @ MON | 76 | W 2-1 | 37-39 | 5 | 30,287 | Mike Scott | Scott Sanderson | Mike Scott | Scott Sanderson | Neil Allen | 293 | 324 | -31 |
| 1982-07-02 | vs PHI | 77 | W 8-4 | 38-39 | 5 | 17,528 | Craig Swan | Marty Bystrom | Craig Swan | Marty Bystrom | Terry Leach | 301 | 328 | -27 |
| 1982-07-04 | vs PHI | 78 | L 7-9 | 38-41 | 5 | 0 | Charlie Puleo | Steve Carlton | Steve Carlton | Charlie Puleo | | 308 | 337 | -29 |
| 1982-07-04 | vs PHI | 79 | L 2-7 | 38-41 | 5 | 20,897 | Randy Jones | Mike Krukow | Mike Krukow | Randy Jones | | 310 | 344 | -34 |
| 1982-07-05 | vs LAN | 80 | L 1-4 | 38-42 | 5 | 38,270 | Pete Falcone | Bob Welch | Bob Welch | Pete Falcone | | 311 | 348 | -37 |
| 1982-07-06 | vs LAN | 81 | L 3-9 | 38-43 | 5 | 20,816 | Mike Scott | Dave Stewart | Dave Stewart | Mike Scott | | 314 | 357 | -43 |
| 1982-07-07 | vs SFN | 82 | L 2-3 | 38-44 | 5 | 13,875 | Brent Gaff | Rich Gale | Rich Gale | Brent Gaff | Greg Minton | 316 | 360 | -44 |
| 1982-07-08 | vs SFN | 83 | L 7-9 | 38-45 | 5 | 12,087 | Jesse Orosco | Renie Martin | Renie Martin | Jesse Orosco | Greg Minton | 323 | 369 | -46 |
| 1982-07-09 | vs SDN | 84 | L 3-5 | 39-46 | 5 | 0 | Charlie Puleo | Chris Welsh | Floyd Chiffer | Charlie Puleo | Luis DeLeon | 326 | 374 | -48 |
| 1982-07-09 | vs SDN | 85 | W 6-3 | 39-46 | 5 | 16,546 | Ed Lynch | Juan Eichelberger | Pat Zachry | Gary Lucas | Neil Allen | 332 | 377 | -45 |
| 1982-07-10 | vs SDN | 86 | W 9-7 | 40-46 | 5 | 51,515 | Pete Falcone | John Curtis | Pete Falcone | John Curtis | Terry Leach | 341 | 384 | -43 |
| 1982-07-11 | vs SDN | 87 | L 2-6 | 40-47 | 5 | 20,240 | Mike Scott | Tim Lollar | Tim Lollar | Mike Scott | | 343 | 390 | -47 |
| 1982-07-15 | @ LAN | 88 | W 5-2 | 41-47 | 5 | 39,330 | Charlie Puleo | Jerry Reuss | Charlie Puleo | Jerry Reuss | Terry Leach | 348 | 392 | -44 |
| 1982-07-16 | @ LAN | 89 | L 6-7 | 41-48 | 5 | 49,953 | Pete Falcone | Fernando Valenzuela | Fernando Valenzuela | Pat Zachry | Steve Howe | 354 | 399 | -45 |
| 1982-07-17 | @ LAN | 90 | L 5-6 | 41-49 | 5 | 42,690 | Brent Gaff | Dave Stewart | Steve Shirley | Neil Allen | | 359 | 405 | -46 |
| 1982-07-18 | @ LAN | 91 | W 8-3 | 42-49 | 5 | 47,595 | Mike Scott | Bob Welch | Mike Scott | Bob Welch | Craig Swan | 367 | 408 | -41 |
| 1982-07-20 | @ SFN | 92 | L 1-5 | 42-50 | 5 | 9,569 | Charlie Puleo | Rich Gale | Rich Gale | Charlie Puleo | Al Holland | 368 | 413 | -45 |
| 1982-07-21 | @ SFN | 93 | W 6-2 | 43-50 | 5 | 7,916 | Pete Falcone | Bill Laskey | Pete Falcone | Bill Laskey | Jesse Orosco | 374 | 415 | -41 |
| 1982-07-23 | @ SDN | 94 | L 4-11 | 43-51 | 5 | 13,858 | Brent Gaff | Andy Hawkins | Andy Hawkins | Brent Gaff | | 378 | 426 | -48 |
| 1982-07-24 | @ SDN | 95 | W 4-3 | 44-51 | 5 | 17,978 | Craig Swan | Chris Welsh | Neil Allen | Luis DeLeon | Pete Falcone | 382 | 429 | -47 |
| 1982-07-25 | @ SDN | 96 | L 2-3 | 44-52 | 5 | 12,614 | Charlie Puleo | John Montefusco | Luis DeLeon | Neil Allen | | 384 | 432 | -48 |
| 1982-07-27 | @ SLN | 97 | L 4-9 | 44-53 | 5 | 24,950 | Mike Scott | Steve Mura | Jeff Lahti | Mike Scott | Doug Bair | 388 | 441 | -53 |
| 1982-07-28 | @ SLN | 98 | L 5-7 | 44-54 | 5 | 22,392 | Brent Gaff | Joaquin Andujar | Jeff Keener | Ed Lynch | Bruce Sutter | 393 | 448 | -55 |
| 1982-07-29 | vs PIT | 99 | L 1-4 | 44-55 | 5 | 16,892 | Pete Falcone | Don Robinson | Don Robinson | Pete Falcone | | 394 | 452 | -58 |
| 1982-07-30 | vs PIT | 100 | L 1-5 | 44-56 | 5 | 18,828 | Craig Swan | John Candelaria | John Candelaria | Craig Swan | Manny Sarmiento | 395 | 457 | -62 |
| 1982-07-31 | vs PIT | 101 | W 9-4 | 45-56 | 5 | 48,358 | Charlie Puleo | Larry McWilliams | Charlie Puleo | Kent Tekulve | Neil Allen | 404 | 461 | -57 |
| 1982-08-01 | vs PIT | 102 | L 3-4 | 45-57 | 5 | 21,871 | Mike Scott | Ross Baumgarten | Kent Tekulve | Terry Leach | Rod Scurry | 407 | 465 | -58 |
| 1982-08-03 | @ CHN | 103 | L 0-5 | 45-58 | 5 | 13,070 | Brent Gaff | Doug Bird | Doug Bird | Brent Gaff | | 407 | 470 | -63 |
| 1982-08-04 | @ CHN | 104 | W 7-4 | 46-58 | 5 | 9,237 | Craig Swan | Fergie Jenkins | Craig Swan | Fergie Jenkins | Pete Falcone | 414 | 474 | -60 |
| 1982-08-05 | @ CHN | 105 | L 1-5 | 46-59 | 5 | 15,658 | Charlie Puleo | Randy Martz | Randy Martz | Charlie Puleo | | 415 | 479 | -64 |
| 1982-08-06 | @ PIT | 106 | L 3-7 | 47-60 | 5 | 0 | Mike Scott | Manny Sarmiento | Manny Sarmiento | Mike Scott | | 418 | 486 | -68 |
| 1982-08-06 | @ PIT | 107 | W 7-3 | 47-60 | 5 | 21,210 | Randy Jones | Ross Baumgarten | Randy Jones | Ross Baumgarten | Neil Allen | 425 | 489 | -64 |
| 1982-08-07 | @ PIT | 108 | W 5-2 | 48-60 | 5 | 19,938 | Pat Zachry | Rick Rhoden | Pat Zachry | Rick Rhoden | | 430 | 491 | -61 |
| 1982-08-08 | @ PIT | 109 | L 1-4 | 48-61 | 5 | 19,679 | Craig Swan | Don Robinson | Don Robinson | Craig Swan | Kent Tekulve | 431 | 495 | -64 |
| 1982-08-09 | vs SLN | 110 | L 2-7 | 48-62 | 5 | 11,383 | Charlie Puleo | Dave LaPoint | Jeff Lahti | Charlie Puleo | | 433 | 502 | -69 |
| 1982-08-10 | vs SLN | 111 | L 2-7 | 48-63 | 5 | 15,833 | Randy Jones | Steve Mura | Steve Mura | Randy Jones | | 435 | 509 | -74 |
| 1982-08-12 | vs CHN | 112 | L 6-13 | 48-64 | 5 | 11,942 | Mike Scott | Dickie Noles | Mike Proly | Jesse Orosco | Dick Tidrow | 441 | 522 | -81 |
| 1982-08-13 | vs CHN | 113 | W 6-4 | 49-64 | 5 | 12,617 | Pat Zachry | Doug Bird | Jesse Orosco | Mike Proly | | 447 | 526 | -79 |
| 1982-08-14 | vs CHN | 114 | L 4-7 | 49-65 | 5 | 21,906 | Craig Swan | Fergie Jenkins | Mike Proly | Pete Falcone | Lee Smith | 451 | 533 | -82 |
| 1982-08-15 | vs CHN | 115 | W 5-4 | 50-66 | 5 | 0 | Ed Lynch | Randy Martz | Ed Lynch | Randy Martz | Pat Zachry | 456 | 537 | -81 |
| 1982-08-15 | vs CHN | 116 | L 5-6 | 50-66 | 5 | 23,545 | Charlie Puleo | Ken Kravec | Mike Proly | Jesse Orosco | Lee Smith | 461 | 543 | -82 |
| 1982-08-17 | @ CIN | 117 | L 2-9 | 50-67 | 5 | 12,031 | Rick Ownbey | Mario Soto | Mario Soto | Rick Ownbey | | 463 | 552 | -89 |
| 1982-08-18 | @ CIN | 118 | L 6-7 | 50-68 | 5 | 12,182 | Pat Zachry | Frank Pastore | Ben Hayes | Mike Scott | | 469 | 559 | -90 |
| 1982-08-19 | @ CIN | 119 | L 1-3 | 50-69 | 6 | 11,279 | Craig Swan | Bruce Berenyi | Jim Kern | Tom Hausman | | 470 | 562 | -92 |
| 1982-08-20 | @ ATL | 120 | L 1-2 | 50-70 | 6 | 33,144 | Ed Lynch | Pascual Perez | Steve Bedrosian | Pat Zachry | | 471 | 564 | -93 |
| 1982-08-21 | @ ATL | 121 | L 5-6 | 50-71 | 6 | 41,477 | Charlie Puleo | Bob Walk | Bob Walk | Randy Jones | Gene Garber | 476 | 570 | -94 |
| 1982-08-22 | @ ATL | 122 | L 9-10 | 50-72 | 6 | 20,466 | Rick Ownbey | Rick Mahler | Carlos Diaz | Jesse Orosco | Gene Garber | 485 | 580 | -95 |
| 1982-08-23 | @ HOU | 123 | L 0-2 | 50-73 | 6 | 10,683 | Pat Zachry | Joe Niekro | Joe Niekro | Pat Zachry | | 485 | 582 | -97 |
| 1982-08-24 | @ HOU | 124 | L 4-5 | 50-74 | 6 | 21,108 | Craig Swan | Bob Knepper | Dave Smith | Mike Scott | | 489 | 587 | -98 |
| 1982-08-25 | @ HOU | 125 | L 4-5 | 50-75 | 6 | 9,651 | Ed Lynch | Don Sutton | Don Sutton | Ed Lynch | Bert Roberge | 493 | 592 | -99 |
| 1982-08-27 | vs ATL | 126 | L 8-9 | 50-76 | 6 | 14,133 | Charlie Puleo | Bob Walk | Donnie Moore | Jesse Orosco | | 501 | 601 | -100 |
| 1982-08-28 | vs ATL | 127 | L 3-4 | 50-77 | 6 | 22,017 | Rick Ownbey | Rick Camp | Rick Camp | Mike Scott | Gene Garber | 504 | 605 | -101 |
| 1982-08-29 | vs ATL | 128 | L 4-9 | 50-78 | 6 | 34,471 | Pat Zachry | Phil Niekro | Phil Niekro | Tom Hausman | Steve Bedrosian | 508 | 614 | -106 |
| 1982-08-30 | vs HOU | 129 | L 2-4 | 50-79 | 6 | 8,497 | Craig Swan | Mike LaCoss | Frank LaCorte | Craig Swan | Dave Smith | 510 | 618 | -108 |
| 1982-08-31 | vs HOU | 130 | L 0-4 | 50-80 | 6 | 9,577 | Ed Lynch | Nolan Ryan | Nolan Ryan | Ed Lynch | | 510 | 622 | -112 |
| 1982-09-01 | vs HOU | 131 | W 5-1 | 51-80 | 6 | 4,488 | Pete Falcone | Vern Ruhle | Pete Falcone | Vern Ruhle | | 515 | 623 | -108 |
| 1982-09-03 | vs CIN | 132 | L 0-1 | 51-81 | 6 | 8,570 | Rick Ownbey | Frank Pastore | Frank Pastore | Rick Ownbey | Brad Lesley | 515 | 624 | -109 |
| 1982-09-04 | vs CIN | 133 | W 3-2 | 52-81 | 6 | 11,032 | Craig Swan | Bruce Berenyi | Craig Swan | Bruce Berenyi | Charlie Puleo | 518 | 626 | -108 |
| 1982-09-05 | vs CIN | 134 | W 10-2 | 53-81 | 6 | 13,644 | Ed Lynch | Bob Shirley | Ed Lynch | Bob Shirley | Jesse Orosco | 528 | 628 | -100 |
| 1982-09-06 | @ PIT | 135 | L 1-6 | 53-82 | 6 | 38,052 | Pete Falcone | Rick Rhoden | Rick Rhoden | Pete Falcone | | 529 | 634 | -105 |
| 1982-09-07 | @ PIT | 136 | L 5-9 | 53-83 | 6 | 6,837 | Mike Scott | Manny Sarmiento | Manny Sarmiento | Mike Scott | | 534 | 643 | -109 |
| 1982-09-08 | @ PIT | 137 | W 9-1 | 54-83 | 6 | 7,092 | Rick Ownbey | Don Robinson | Rick Ownbey | Don Robinson | | 543 | 644 | -101 |
| 1982-09-10 | @ SLN | 138 | W 2-1 | 55-83 | 6 | 19,928 | Craig Swan | John Stuper | Craig Swan | John Stuper | Jesse Orosco | 545 | 645 | -100 |
| 1982-09-11 | @ SLN | 139 | L 3-6 | 55-84 | 6 | 28,821 | Ed Lynch | Joaquin Andujar | Joaquin Andujar | Ed Lynch | Bruce Sutter | 548 | 651 | -103 |
| 1982-09-12 | @ SLN | 140 | W 4-1 | 56-84 | 6 | 26,817 | Pete Falcone | Steve Mura | Pete Falcone | Steve Mura | | 552 | 652 | -100 |
| 1982-09-14 | @ MON | 141 | L 1-3 | 56-85 | 6 | 21,512 | Pat Zachry | Charlie Lea | Charlie Lea | Pat Zachry | Jeff Reardon | 553 | 655 | -102 |
| 1982-09-15 | @ MON | 142 | L 5-6 | 56-86 | 6 | 16,500 | Rick Ownbey | Steve Rogers | Woodie Fryman | Doug Sisk | | 558 | 661 | -103 |
| 1982-09-16 | @ MON | 143 | W 9-4 | 57-86 | 6 | 24,165 | Craig Swan | Scott Sanderson | Craig Swan | Scott Sanderson | | 567 | 665 | -98 |
| 1982-09-17 | vs SLN | 144 | L 2-3 | 57-88 | 6 | 0 | Ed Lynch | Eric Rasmussen | Bruce Sutter | Neil Allen | | 569 | 668 | -99 |
| 1982-09-17 | vs SLN | 145 | L 1-7 | 57-88 | 6 | 8,622 | Scott Holman | Steve Mura | Steve Mura | Scott Holman | Doug Bair | 570 | 675 | -105 |
| 1982-09-18 | vs SLN | 146 | L 0-2 | 57-90 | 6 | 0 | Pete Falcone | Bob Forsch | Bob Forsch | Pete Falcone | Bruce Sutter | 570 | 677 | -107 |
| 1982-09-18 | vs SLN | 147 | L 2-6 | 57-90 | 6 | 9,900 | Walt Terrell | Jim Kaat | Jeff Lahti | Walt Terrell | | 572 | 683 | -111 |
| 1982-09-19 | vs SLN | 148 | L 1-3 | 57-91 | 6 | 9,868 | Pat Zachry | John Stuper | John Stuper | Pat Zachry | Doug Bair | 573 | 686 | -113 |
| 1982-09-21 | vs MON | 149 | W 2-1 | 58-92 | 6 | 0 | Rick Ownbey | Charlie Lea | Jesse Orosco | Bryn Smith | | 575 | 687 | -112 |
| 1982-09-21 | vs MON | 150 | L 1-5 | 58-92 | 6 | 2,251 | Craig Swan | Scott Sanderson | Scott Sanderson | Craig Swan | | 576 | 692 | -116 |
| 1982-09-22 | @ CHN | 151 | W 5-2 | 59-92 | 6 | 3,142 | Scott Holman | Randy Martz | Scott Holman | Randy Martz | Doug Sisk | 581 | 694 | -113 |
| 1982-09-23 | @ CHN | 152 | W 5-4 | 60-92 | 6 | 4,344 | Ed Lynch | Doug Bird | Ed Lynch | Doug Bird | Jesse Orosco | 586 | 698 | -112 |
| 1982-09-24 | vs PHI | 153 | L 1-2 | 60-93 | 6 | 7,661 | Walt Terrell | Mike Krukow | Mike Krukow | Walt Terrell | Ron Reed | 587 | 700 | -113 |
| 1982-09-25 | vs PHI | 154 | W 2-1 | 61-93 | 6 | 8,870 | Craig Swan | Steve Carlton | Craig Swan | Steve Carlton | | 589 | 701 | -112 |
| 1982-09-26 | vs PHI | 155 | W 6-4 | 62-93 | 6 | 16,384 | Rick Ownbey | John Denny | Charlie Puleo | Ed Farmer | | 595 | 705 | -110 |
| 1982-09-27 | vs PIT | 156 | W 4-1 | 63-93 | 6 | 4,412 | Scott Holman | Rick Rhoden | Scott Holman | Rick Rhoden | | 599 | 706 | -107 |
| 1982-09-28 | vs PIT | 157 | W 3-2 | 64-93 | 6 | 3,921 | Ed Lynch | John Candelaria | Jesse Orosco | Enrique Romo | | 602 | 708 | -106 |
| 1982-09-29 | vs CHN | 158 | L 1-4 | 64-94 | 6 | 3,175 | Walt Terrell | Mike Proly | Mike Proly | Walt Terrell | Lee Smith | 603 | 712 | -109 |
| 1982-09-30 | vs CHN | 159 | L 1-3 | 64-95 | 6 | 5,293 | Tom Gorman | Dickie Noles | Dickie Noles | Tom Gorman | Lee Smith | 604 | 715 | -111 |
| 1982-10-01 | @ PHI | 160 | W 1-0 | 65-95 | 6 | 16,072 | Terry Leach | John Denny | Terry Leach | Porfi Altamirano | | 605 | 715 | -110 |
| 1982-10-02 | @ PHI | 161 | L 3-4 | 65-96 | 6 | 32,729 | Scott Holman | Marty Bystrom | Porfi Altamirano | Pat Zachry | | 608 | 719 | -111 |
| 1982-10-03 | @ PHI | 162 | L 1-4 | 65-97 | 6 | 19,383 | Ed Lynch | Steve Carlton | Steve Carlton | Ed Lynch | | 609 | 723 | -114 |