| 1982-04-05 | @ BAL | 1 | L 5-13 | 0-1 | 2 | 51,958 | Dennis Leonard | Dennis Martinez | Sammy Stewart | Dennis Leonard | | 5 | 13 | -8 |
| 1982-04-09 | vs DET | 2 | W 4-2 | 1-1 | 2 | 29,069 | Larry Gura | Jack Morris | Larry Gura | Jack Morris | | 9 | 15 | -6 |
| 1982-04-10 | vs DET | 3 | W 5-2 | 2-1 | 2 | 19,508 | Dennis Leonard | Dan Petry | Dennis Leonard | Dan Petry | Dan Quisenberry | 14 | 17 | -3 |
| 1982-04-11 | vs DET | 4 | L 1-2 | 2-2 | 3 | 22,962 | Vida Blue | Dave Rozema | Dave Rozema | Vida Blue | Kevin Saucier | 15 | 19 | -4 |
| 1982-04-13 | vs BAL | 5 | W 6-5 | 3-2 | 2 | 14,662 | Larry Gura | Jim Palmer | Dave Frost | Sammy Stewart | Dan Quisenberry | 21 | 24 | -3 |
| 1982-04-14 | vs BAL | 6 | W 4-3 | 4-2 | 2 | 20,382 | Dennis Leonard | Scott McGregor | Dave Frost | Don Stanhouse | | 25 | 27 | -2 |
| 1982-04-16 | @ CLE | 7 | W 3-1 | 5-2 | 2 | 6,360 | Vida Blue | Len Barker | Vida Blue | Len Barker | Dan Quisenberry | 28 | 28 | 0 |
| 1982-04-17 | @ CLE | 8 | W 12-10 | 6-2 | 2 | 7,089 | Larry Gura | Lary Sorensen | Dave Frost | Rick Waits | Dan Quisenberry | 40 | 38 | 2 |
| 1982-04-18 | @ CLE | 9 | L 2-8 | 6-3 | 3 | 11,373 | Buddy Black | John Denny | John Denny | Buddy Black | | 42 | 46 | -4 |
| 1982-04-19 | @ DET | 10 | L 2-3 | 6-4 | 4 | 10,809 | Paul Splittorff | Larry Pashnick | Kevin Saucier | Dan Quisenberry | Elias Sosa | 44 | 49 | -5 |
| 1982-04-20 | @ DET | 11 | L 0-8 | 6-5 | 4 | 10,654 | Vida Blue | Milt Wilcox | Milt Wilcox | Vida Blue | | 44 | 57 | -13 |
| 1982-04-21 | @ DET | 12 | L 1-4 | 6-6 | 5 | 12,583 | Larry Gura | Pat Underwood | Pat Underwood | Larry Gura | | 45 | 61 | -16 |
| 1982-04-23 | vs CLE | 13 | W 11-6 | 7-6 | 3 | 24,332 | Dennis Leonard | Lary Sorensen | Grant Jackson | Lary Sorensen | | 56 | 67 | -11 |
| 1982-04-24 | vs CLE | 14 | W 5-1 | 8-6 | 3 | 25,065 | Paul Splittorff | John Denny | Paul Splittorff | John Denny | Dan Quisenberry | 61 | 68 | -7 |
| 1982-04-25 | vs CLE | 15 | W 6-3 | 9-6 | 3 | 20,867 | Larry Gura | Bert Blyleven | Larry Gura | Bert Blyleven | | 67 | 71 | -4 |
| 1982-04-27 | @ BOS | 16 | L 5-7 | 9-7 | 3 | 12,998 | Dave Frost | Dennis Eckersley | Bob Stanley | Dave Frost | | 72 | 78 | -6 |
| 1982-04-28 | @ BOS | 17 | W 8-5 | 10-7 | 3 | 12,368 | Dennis Leonard | John Tudor | Dennis Leonard | John Tudor | | 80 | 83 | -3 |
| 1982-04-29 | vs TOR | 18 | L 0-7 | 10-8 | 3 | 15,707 | Paul Splittorff | Dave Stieb | Dave Stieb | Paul Splittorff | | 80 | 90 | -10 |
| 1982-04-30 | vs TOR | 19 | W 8-7 | 11-8 | 3 | 19,030 | Larry Gura | Luis Leal | Grant Jackson | Roy Lee Jackson | Dan Quisenberry | 88 | 97 | -9 |
| 1982-05-01 | vs TOR | 20 | W 8-7 | 12-8 | 2 | 23,561 | Dave Frost | Mark Bomback | Grant Jackson | Mark Bomback | Dan Quisenberry | 96 | 104 | -8 |
| 1982-05-02 | vs TOR | 21 | L 5-7 | 12-9 | 3 | 27,044 | Dennis Leonard | Jim Clancy | Jim Clancy | Dennis Leonard | Roy Lee Jackson | 101 | 111 | -10 |
| 1982-05-03 | @ MIL | 22 | W 3-2 | 13-9 | 2 | 8,313 | Paul Splittorff | Mike Caldwell | Paul Splittorff | Mike Caldwell | Dan Quisenberry | 104 | 113 | -9 |
| 1982-05-04 | @ MIL | 23 | L 5-9 | 13-10 | 4 | 7,646 | Larry Gura | Bob McClure | Jim Slaton | Grant Jackson | | 109 | 122 | -13 |
| 1982-05-05 | @ MIL | 24 | W 3-2 | 14-10 | 3 | 9,833 | Vida Blue | Moose Haas | Dan Quisenberry | Rollie Fingers | | 112 | 124 | -12 |
| 1982-05-07 | @ TOR | 25 | L 4-6 | 14-11 | 4 | 11,523 | Dennis Leonard | Jim Clancy | Joey McLaughlin | Dennis Leonard | | 116 | 130 | -14 |
| 1982-05-08 | @ TOR | 26 | L 1-2 | 14-12 | 4 | 15,102 | Dave Frost | Mark Bomback | Mark Bomback | Dave Frost | Roy Lee Jackson | 117 | 132 | -15 |
| 1982-05-09 | @ TOR | 27 | L 0-2 | 14-13 | 4 | 17,044 | Paul Splittorff | Dave Stieb | Dave Stieb | Paul Splittorff | | 117 | 134 | -17 |
| 1982-05-10 | vs MIL | 28 | W 3-2 | 15-13 | 4 | 26,835 | Vida Blue | Moose Haas | Vida Blue | Rollie Fingers | | 120 | 136 | -16 |
| 1982-05-11 | vs MIL | 29 | W 17-3 | 16-13 | 3 | 16,240 | Larry Gura | Jerry Augustine | Larry Gura | Jerry Augustine | | 137 | 139 | -2 |
| 1982-05-12 | vs MIL | 30 | W 9-7 | 17-13 | 3 | 17,788 | Dennis Leonard | Randy Lerch | Dennis Leonard | Randy Lerch | Dan Quisenberry | 146 | 146 | 0 |
| 1982-05-13 | vs BOS | 31 | W 11-2 | 18-13 | 3 | 17,459 | Dave Frost | Chuck Rainey | Dave Frost | Chuck Rainey | | 157 | 148 | 9 |
| 1982-05-15 | vs BOS | 32 | L 5-10 | 18-14 | 3 | 37,506 | Vida Blue | Mike Torrez | Mike Torrez | Vida Blue | Mark Clear | 162 | 158 | 4 |
| 1982-05-16 | vs BOS | 33 | W 5-0 | 19-14 | 3 | 34,395 | Dennis Leonard | Bob Ojeda | Dennis Leonard | Bob Ojeda | | 167 | 158 | 9 |
| 1982-05-17 | vs NYA | 34 | W 7-0 | 20-14 | 3 | 38,955 | Larry Gura | Roger Erickson | Larry Gura | Roger Erickson | | 174 | 158 | 16 |
| 1982-05-18 | vs NYA | 35 | L 2-6 | 20-15 | 3 | 28,076 | Dave Frost | Ron Guidry | Ron Guidry | Dave Frost | | 176 | 164 | 12 |
| 1982-05-19 | vs NYA | 36 | L 2-3 | 20-16 | 3 | 26,121 | Paul Splittorff | Tommy John | Tommy John | Paul Splittorff | Rich Gossage | 178 | 167 | 11 |
| 1982-05-21 | vs TEX | 37 | W 3-0 | 21-16 | 3 | 31,212 | Dennis Leonard | Frank Tanana | Dennis Leonard | Frank Tanana | Dan Quisenberry | 181 | 167 | 14 |
| 1982-05-22 | vs TEX | 38 | L 1-3 | 21-17 | 3 | 28,839 | Larry Gura | Charlie Hough | Charlie Hough | Dan Quisenberry | | 182 | 170 | 12 |
| 1982-05-23 | vs TEX | 39 | W 5-3 | 22-17 | 3 | 27,330 | Dave Frost | Rick Honeycutt | Mike Armstrong | Rick Honeycutt | Dan Quisenberry | 187 | 173 | 14 |
| 1982-05-24 | @ CHA | 40 | L 1-3 | 22-18 | 3 | 12,020 | Paul Splittorff | LaMarr Hoyt | LaMarr Hoyt | Paul Splittorff | | 188 | 176 | 12 |
| 1982-05-25 | @ CHA | 41 | W 7-4 | 23-18 | 3 | 13,414 | Keith Creel | Richard Dotson | Keith Creel | Richard Dotson | Dan Quisenberry | 195 | 180 | 15 |
| 1982-05-26 | @ CHA | 42 | L 5-7 | 23-19 | 3 | 12,359 | Larry Gura | Britt Burns | Britt Burns | Larry Gura | Salome Barojas | 200 | 187 | 13 |
| 1982-05-28 | @ TEX | 43 | L 2-8 | 23-20 | 3 | 11,721 | Dave Frost | Charlie Hough | Charlie Hough | Dave Frost | | 202 | 195 | 7 |
| 1982-05-29 | @ TEX | 44 | W 14-1 | 24-20 | 3 | 19,532 | Paul Splittorff | Rick Honeycutt | Paul Splittorff | Rick Honeycutt | | 216 | 196 | 20 |
| 1982-05-30 | @ TEX | 45 | L 1-8 | 24-21 | 3 | 13,575 | Keith Creel | Doc Medich | Doc Medich | Keith Creel | | 217 | 204 | 13 |
| 1982-05-31 | vs CHA | 46 | W 11-4 | 25-21 | 3 | 40,640 | Larry Gura | Britt Burns | Larry Gura | Britt Burns | | 228 | 208 | 20 |
| 1982-06-01 | vs CHA | 47 | W 4-3 | 26-21 | 3 | 24,868 | Vida Blue | Richard Dotson | Vida Blue | Richard Dotson | Dan Quisenberry | 232 | 211 | 21 |
| 1982-06-02 | vs CHA | 48 | W 7-6 | 27-21 | 3 | 17,407 | Dave Frost | Steve Trout | Mike Armstrong | Salome Barojas | | 239 | 217 | 22 |
| 1982-06-04 | @ NYA | 49 | W 4-3 | 28-21 | 3 | 25,221 | Paul Splittorff | Dave Righetti | Paul Splittorff | Dave Righetti | Dan Quisenberry | 243 | 220 | 23 |
| 1982-06-06 | @ NYA | 50 | W 14-1 | 29-21 | 1 | 32,068 | Vida Blue | Mike Morgan | Vida Blue | Mike Morgan | | 257 | 221 | 36 |
| 1982-06-07 | @ MIN | 51 | W 5-4 | 30-21 | 1 | 6,274 | Keith Creel | Bobby Castillo | Dan Quisenberry | Pete Redfern | | 262 | 225 | 37 |
| 1982-06-08 | @ MIN | 52 | W 9-4 | 31-21 | 1 | 6,543 | Larry Gura | Jack O'Connor | Larry Gura | Jack O'Connor | | 271 | 229 | 42 |
| 1982-06-09 | @ MIN | 53 | W 8-5 | 32-21 | 1 | 7,030 | Paul Splittorff | Albert Williams | Paul Splittorff | Albert Williams | Dan Quisenberry | 279 | 234 | 45 |
| 1982-06-10 | @ MIN | 54 | L 7-8 | 32-22 | 1 | 13,667 | Dave Frost | Frank Viola | Pete Redfern | Mike Armstrong | | 286 | 242 | 44 |
| 1982-06-11 | vs SEA | 55 | W 3-2 | 33-22 | 1 | 34,824 | Vida Blue | Gaylord Perry | Dan Quisenberry | Ed Vande Berg | | 289 | 244 | 45 |
| 1982-06-12 | vs SEA | 56 | L 2-3 | 33-23 | 1 | 32,098 | Keith Creel | Gene Nelson | Gene Nelson | Keith Creel | Bill Caudill | 291 | 247 | 44 |
| 1982-06-13 | vs SEA | 57 | L 1-7 | 33-24 | 2 | 30,683 | Larry Gura | Floyd Bannister | Floyd Bannister | Larry Gura | | 292 | 254 | 38 |
| 1982-06-14 | vs MIN | 58 | W 3-0 | 34-24 | 1 | 28,448 | Paul Splittorff | Brad Havens | Paul Splittorff | Brad Havens | Dan Quisenberry | 295 | 254 | 41 |
| 1982-06-15 | vs MIN | 59 | W 7-4 | 35-24 | 1 | 21,633 | Buddy Black | Albert Williams | Buddy Black | Albert Williams | Dan Quisenberry | 302 | 258 | 44 |
| 1982-06-16 | vs MIN | 60 | L 2-5 | 35-25 | 1 | 25,790 | Vida Blue | Frank Viola | Frank Viola | Vida Blue | | 304 | 263 | 41 |
| 1982-06-18 | @ SEA | 61 | W 4-1 | 36-25 | 2 | 13,057 | Larry Gura | Floyd Bannister | Larry Gura | Bill Caudill | Dan Quisenberry | 308 | 264 | 44 |
| 1982-06-19 | @ SEA | 62 | L 3-10 | 36-26 | 2 | 22,150 | Keith Creel | Jim Beattie | Jim Beattie | Keith Creel | | 311 | 274 | 37 |
| 1982-06-20 | @ SEA | 63 | W 7-5 | 37-26 | 2 | 17,468 | Paul Splittorff | Gaylord Perry | Paul Splittorff | Gaylord Perry | Dan Quisenberry | 318 | 279 | 39 |
| 1982-06-21 | @ OAK | 64 | L 3-4 | 37-27 | 2 | 30,928 | Vida Blue | Tom Underwood | Dave Beard | Vida Blue | | 321 | 283 | 38 |
| 1982-06-22 | @ OAK | 65 | W 2-1 | 38-27 | 2 | 15,326 | Buddy Black | Matt Keough | Buddy Black | Matt Keough | Dan Quisenberry | 323 | 284 | 39 |
| 1982-06-23 | @ OAK | 66 | W 1-0 | 39-27 | 2 | 15,591 | Larry Gura | Brian Kingman | Larry Gura | Brian Kingman | | 324 | 284 | 40 |
| 1982-06-24 | @ CAL | 67 | L 2-7 | 39-28 | 2 | 29,250 | Keith Creel | Geoff Zahn | Geoff Zahn | Keith Creel | | 326 | 291 | 35 |
| 1982-06-25 | @ CAL | 68 | W 8-6 | 40-28 | 2 | 34,301 | Paul Splittorff | Mike Witt | Dan Quisenberry | Angel Moreno | | 334 | 297 | 37 |
| 1982-06-26 | @ CAL | 69 | L 5-6 | 40-29 | 2 | 56,794 | Vida Blue | Steve Renko | Ken Forsch | Dan Quisenberry | | 339 | 303 | 36 |
| 1982-06-27 | @ CAL | 70 | L 1-9 | 40-30 | 2 | 36,572 | Buddy Black | Dave Goltz | Dave Goltz | Buddy Black | | 340 | 312 | 28 |
| 1982-06-28 | vs OAK | 71 | L 4-8 | 40-31 | 3 | 40,728 | Larry Gura | Rick Langford | Rick Langford | Larry Gura | | 344 | 320 | 24 |
| 1982-06-29 | vs OAK | 72 | W 7-2 | 41-31 | 2 | 26,837 | Don Hood | Dave Beard | Don Hood | Dave Beard | Mike Armstrong | 351 | 322 | 29 |
| 1982-06-30 | vs OAK | 73 | L 0-4 | 41-32 | 2 | 24,882 | Paul Splittorff | Matt Keough | Matt Keough | Paul Splittorff | | 351 | 326 | 25 |
| 1982-07-02 | vs CAL | 74 | W 7-2 | 42-32 | 2 | 29,609 | Vida Blue | Steve Renko | Vida Blue | Steve Renko | Mike Armstrong | 358 | 328 | 30 |
| 1982-07-03 | vs CAL | 75 | W 6-2 | 43-32 | 2 | 41,380 | Larry Gura | Dave Goltz | Larry Gura | Dave Goltz | Dan Quisenberry | 364 | 330 | 34 |
| 1982-07-04 | vs CAL | 76 | W 6-1 | 44-32 | 1 | 33,360 | Buddy Black | Geoff Zahn | Buddy Black | Geoff Zahn | | 370 | 331 | 39 |
| 1982-07-05 | vs BOS | 77 | L 3-4 | 45-33 | 1 | 0 | Paul Splittorff | Bruce Hurst | Bob Stanley | Mike Armstrong | | 373 | 335 | 38 |
| 1982-07-05 | vs BOS | 78 | W 4-3 | 45-33 | 1 | 41,024 | Don Hood | Bob Ojeda | Don Hood | Bob Ojeda | Dan Quisenberry | 377 | 338 | 39 |
| 1982-07-06 | vs BOS | 79 | W 6-2 | 46-33 | 1 | 22,380 | Vida Blue | John Tudor | Vida Blue | John Tudor | Bill Castro | 383 | 340 | 43 |
| 1982-07-07 | vs TOR | 80 | W 3-1 | 47-33 | 1 | 22,217 | Larry Gura | Jim Clancy | Larry Gura | Jim Clancy | | 386 | 341 | 45 |
| 1982-07-08 | vs TOR | 81 | L 4-5 | 47-34 | 1 | 24,409 | Buddy Black | Dave Stieb | Dave Stieb | Mike Armstrong | Joey McLaughlin | 390 | 346 | 44 |
| 1982-07-09 | @ MIL | 82 | L 6-9 | 47-35 | 1 | 26,983 | Paul Splittorff | Mike Caldwell | Mike Caldwell | Paul Splittorff | Rollie Fingers | 396 | 355 | 41 |
| 1982-07-10 | @ MIL | 83 | L 0-7 | 47-36 | 1 | 33,641 | Vida Blue | Randy Lerch | Randy Lerch | Vida Blue | | 396 | 362 | 34 |
| 1982-07-11 | @ MIL | 84 | L 5-8 | 47-37 | 2 | 26,357 | Larry Gura | Moose Haas | Moose Haas | Larry Gura | Rollie Fingers | 401 | 370 | 31 |
| 1982-07-15 | @ BOS | 85 | L 3-5 | 47-38 | 2 | 29,186 | Larry Gura | Mike Torrez | Tom Burgmeier | Larry Gura | | 404 | 375 | 29 |
| 1982-07-16 | @ BOS | 86 | L 3-7 | 47-39 | 2 | 30,811 | Vida Blue | Dennis Eckersley | Dennis Eckersley | Vida Blue | Bob Stanley | 407 | 382 | 25 |
| 1982-07-17 | @ BOS | 87 | L 4-8 | 47-40 | 2 | 30,962 | Paul Splittorff | Bruce Hurst | Mark Clear | Dan Quisenberry | Tom Burgmeier | 411 | 390 | 21 |
| 1982-07-18 | @ BOS | 88 | W 9-0 | 48-40 | 2 | 28,072 | Derek Botelho | John Tudor | Derek Botelho | John Tudor | | 420 | 390 | 30 |
| 1982-07-19 | @ TOR | 89 | L 2-4 | 48-41 | 2 | 16,466 | Buddy Black | Luis Leal | Luis Leal | Buddy Black | | 422 | 394 | 28 |
| 1982-07-20 | @ TOR | 90 | L 2-9 | 48-42 | 2 | 18,552 | Larry Gura | Dave Stieb | Dave Stieb | Larry Gura | | 424 | 403 | 21 |
| 1982-07-21 | @ TOR | 91 | W 9-7 | 49-42 | 2 | 19,152 | Vida Blue | Jim Clancy | Vida Blue | Jim Clancy | Dan Quisenberry | 433 | 410 | 23 |
| 1982-07-23 | vs MIL | 92 | W 4-3 | 50-42 | 2 | 39,526 | Paul Splittorff | Bob McClure | Dan Quisenberry | Rollie Fingers | | 437 | 413 | 24 |
| 1982-07-24 | vs MIL | 93 | L 4-7 | 50-43 | 2 | 40,232 | Derek Botelho | Pete Vuckovich | Pete Vuckovich | Derek Botelho | | 441 | 420 | 21 |
| 1982-07-25 | vs MIL | 94 | W 6-4 | 51-43 | 2 | 38,629 | Larry Gura | Randy Lerch | Larry Gura | Randy Lerch | Mike Armstrong | 447 | 424 | 23 |
| 1982-07-26 | @ CLE | 95 | W 8-1 | 52-43 | 2 | 13,841 | Vida Blue | Tom Brennan | Vida Blue | Tom Brennan | | 455 | 425 | 30 |
| 1982-07-27 | @ CLE | 96 | W 8-1 | 53-43 | 2 | 8,908 | Dave Frost | Rick Waits | Dave Frost | Rick Waits | | 463 | 426 | 37 |
| 1982-07-28 | @ CLE | 97 | L 2-4 | 53-44 | 2 | 9,868 | Paul Splittorff | Rick Sutcliffe | Rick Sutcliffe | Bill Castro | Dan Spillner | 465 | 430 | 35 |
| 1982-07-29 | vs BAL | 98 | W 7-2 | 54-44 | 2 | 36,217 | Derek Botelho | Dennis Martinez | Derek Botelho | Dennis Martinez | | 472 | 432 | 40 |
| 1982-07-30 | vs BAL | 99 | W 4-3 | 55-44 | 2 | 33,844 | Larry Gura | Sammy Stewart | Larry Gura | Sammy Stewart | Dan Quisenberry | 476 | 435 | 41 |
| 1982-07-31 | vs BAL | 100 | W 2-0 | 56-44 | 2 | 40,771 | Vida Blue | Mike Flanagan | Vida Blue | Mike Flanagan | | 478 | 435 | 43 |
| 1982-08-01 | vs BAL | 101 | W 4-2 | 57-44 | 2 | 30,280 | Dave Frost | Jim Palmer | Bill Castro | Tippy Martinez | Dan Quisenberry | 482 | 437 | 45 |
| 1982-08-02 | vs DET | 102 | W 6-5 | 58-44 | 1 | 36,725 | Buddy Black | Larry Pashnick | Dan Quisenberry | Dave Tobik | | 488 | 442 | 46 |
| 1982-08-03 | vs DET | 103 | W 6-5 | 59-44 | 1 | 27,264 | Derek Botelho | Pat Underwood | Mike Armstrong | Pat Underwood | | 494 | 447 | 47 |
| 1982-08-04 | vs DET | 104 | L 1-7 | 59-45 | 1 | 26,340 | Larry Gura | Dan Petry | Dan Petry | Larry Gura | | 495 | 454 | 41 |
| 1982-08-05 | @ BAL | 105 | L 1-5 | 59-46 | 1 | 20,943 | Vida Blue | Jim Palmer | Jim Palmer | Vida Blue | | 496 | 459 | 37 |
| 1982-08-06 | @ BAL | 106 | W 3-1 | 61-46 | 1 | 0 | Dave Frost | Storm Davis | Dave Frost | Storm Davis | Mike Armstrong | 499 | 460 | 39 |
| 1982-08-06 | @ BAL | 107 | W 4-0 | 61-46 | 1 | 25,768 | Don Hood | Scott McGregor | Don Hood | Scott McGregor | Dan Quisenberry | 503 | 460 | 43 |
| 1982-08-07 | @ BAL | 108 | L 5-6 | 61-47 | 2 | 39,649 | Buddy Black | Dennis Martinez | Tippy Martinez | Dan Quisenberry | | 508 | 466 | 42 |
| 1982-08-08 | @ BAL | 109 | L 6-10 | 61-48 | 2 | 26,099 | Dennis Leonard | Mike Flanagan | Tim Stoddard | Mike Armstrong | | 514 | 476 | 38 |
| 1982-08-09 | vs CLE | 110 | W 12-2 | 62-48 | 2 | 40,044 | Larry Gura | Lary Sorensen | Larry Gura | Lary Sorensen | | 526 | 478 | 48 |
| 1982-08-10 | vs CLE | 111 | W 5-1 | 63-48 | 1 | 25,864 | Vida Blue | Rick Waits | Mike Armstrong | Rick Waits | | 531 | 479 | 52 |
| 1982-08-11 | vs CLE | 112 | W 8-0 | 64-48 | 1 | 27,540 | Paul Splittorff | Ed Whitson | Don Hood | Ed Whitson | | 539 | 479 | 60 |
| 1982-08-13 | @ DET | 113 | L 1-10 | 64-49 | 2 | 30,351 | Dave Frost | Milt Wilcox | Milt Wilcox | Dave Frost | Pat Underwood | 540 | 489 | 51 |
| 1982-08-14 | @ DET | 114 | W 1-0 | 65-49 | 2 | 34,346 | Larry Gura | Dan Petry | Larry Gura | Dan Petry | | 541 | 489 | 52 |
| 1982-08-15 | @ DET | 115 | W 6-1 | 66-49 | 1 | 25,930 | Dennis Leonard | Jerry Ujdur | Dennis Leonard | Jerry Ujdur | | 547 | 490 | 57 |
| 1982-08-16 | @ NYA | 116 | L 0-2 | 66-51 | 2 | 0 | Vida Blue | Dave Righetti | Dave Righetti | Vida Blue | Rich Gossage | 547 | 492 | 55 |
| 1982-08-16 | @ NYA | 117 | L 3-4 | 66-51 | 2 | 26,815 | Buddy Black | Rudy May | Rudy May | Buddy Black | Rich Gossage | 550 | 496 | 54 |
| 1982-08-17 | @ NYA | 118 | W 8-4 | 67-51 | 2 | 24,532 | Paul Splittorff | Mike Morgan | Paul Splittorff | Mike Morgan | Don Hood | 558 | 500 | 58 |
| 1982-08-18 | @ NYA | 119 | L 2-9 | 67-52 | 2 | 22,604 | Dave Frost | Tommy John | Tommy John | Dave Frost | | 560 | 509 | 51 |
| 1982-08-19 | vs CHA | 120 | W 3-0 | 68-52 | 2 | 37,093 | Larry Gura | LaMarr Hoyt | Larry Gura | LaMarr Hoyt | Dan Quisenberry | 563 | 509 | 54 |
| 1982-08-20 | vs CHA | 121 | W 13-5 | 69-52 | 1 | 36,328 | Dennis Leonard | Chico Escarrega | Dennis Leonard | Chico Escarrega | Mike Armstrong | 576 | 514 | 62 |
| 1982-08-21 | vs CHA | 122 | W 4-3 | 70-52 | 1 | 40,461 | Buddy Black | Richard Dotson | Dan Quisenberry | Salome Barojas | | 580 | 517 | 63 |
| 1982-08-22 | vs CHA | 123 | L 3-12 | 70-53 | 2 | 33,731 | Paul Splittorff | Jerry Koosman | Jerry Koosman | Paul Splittorff | | 583 | 529 | 54 |
| 1982-08-23 | @ TEX | 124 | L 2-5 | 70-54 | 2 | 8,996 | Vida Blue | Dave J. Schmidt | Dave J. Schmidt | Mike Armstrong | Danny Darwin | 585 | 534 | 51 |
| 1982-08-24 | @ TEX | 125 | W 5-3 | 71-54 | 2 | 9,645 | Larry Gura | Frank Tanana | Larry Gura | Frank Tanana | Dan Quisenberry | 590 | 537 | 53 |
| 1982-08-25 | @ TEX | 126 | W 4-3 | 72-54 | 2 | 8,952 | Dennis Leonard | John Butcher | Dennis Leonard | John Butcher | Dan Quisenberry | 594 | 540 | 54 |
| 1982-08-26 | @ TEX | 127 | W 5-3 | 73-54 | 1 | 9,045 | Buddy Black | Charlie Hough | Buddy Black | Charlie Hough | Dan Quisenberry | 599 | 543 | 56 |
| 1982-08-27 | @ CHA | 128 | W 7-1 | 74-54 | 1 | 42,212 | Paul Splittorff | Jerry Koosman | Paul Splittorff | Jerry Koosman | | 606 | 544 | 62 |
| 1982-08-28 | @ CHA | 129 | W 10-1 | 75-54 | 1 | 24,381 | Vida Blue | Britt Burns | Vida Blue | Britt Burns | | 616 | 545 | 71 |
| 1982-08-29 | @ CHA | 130 | W 7-4 | 76-54 | 1 | 26,181 | Larry Gura | LaMarr Hoyt | Larry Gura | LaMarr Hoyt | Dan Quisenberry | 623 | 549 | 74 |
| 1982-08-30 | vs TEX | 131 | W 8-3 | 77-54 | 1 | 27,290 | Dennis Leonard | John Butcher | Dennis Leonard | John Butcher | | 631 | 552 | 79 |
| 1982-08-31 | vs TEX | 132 | L 0-6 | 77-55 | 1 | 20,425 | Buddy Black | Charlie Hough | Charlie Hough | Buddy Black | | 631 | 558 | 73 |
| 1982-09-01 | vs TEX | 133 | L 3-7 | 77-56 | 1 | 18,201 | Paul Splittorff | Mike Smithson | Mike Smithson | Paul Splittorff | | 634 | 565 | 69 |
| 1982-09-03 | vs NYA | 134 | W 5-3 | 78-56 | 1 | 33,613 | Vida Blue | Jay Howell | Vida Blue | Jay Howell | Dan Quisenberry | 639 | 568 | 71 |
| 1982-09-04 | vs NYA | 135 | L 2-3 | 78-57 | 1 | 37,881 | Larry Gura | Shane Rawley | Shane Rawley | Larry Gura | Rudy May | 641 | 571 | 70 |
| 1982-09-05 | vs NYA | 136 | L 7-18 | 78-58 | 1 | 40,801 | Dennis Leonard | Ron Guidry | Ron Guidry | Dennis Leonard | | 648 | 589 | 59 |
| 1982-09-06 | @ SEA | 137 | L 2-6 | 78-59 | 1 | 10,030 | Buddy Black | Floyd Bannister | Floyd Bannister | Buddy Black | | 650 | 595 | 55 |
| 1982-09-07 | @ SEA | 138 | L 2-5 | 78-60 | 1 | 6,191 | Paul Splittorff | Mike Moore | Mike Moore | Paul Splittorff | Bill Caudill | 652 | 600 | 52 |
| 1982-09-08 | @ SEA | 139 | W 6-2 | 79-60 | 1 | 7,925 | Vida Blue | Jim Beattie | Vida Blue | Jim Beattie | | 658 | 602 | 56 |
| 1982-09-10 | vs MIN | 140 | L 0-5 | 79-61 | 1 | 30,030 | Larry Gura | Bobby Castillo | Bobby Castillo | Larry Gura | | 658 | 607 | 51 |
| 1982-09-11 | vs MIN | 141 | W 9-3 | 80-61 | 1 | 32,961 | Dennis Leonard | Frank Viola | Dennis Leonard | Frank Viola | | 667 | 610 | 57 |
| 1982-09-12 | vs MIN | 142 | W 18-7 | 81-61 | 1 | 32,363 | Paul Splittorff | Brad Havens | Bob Tufts | Terry Felton | Dan Quisenberry | 685 | 617 | 68 |
| 1982-09-13 | vs SEA | 143 | W 8-0 | 82-61 | 1 | 19,508 | Vida Blue | Mike Moore | Vida Blue | Mike Moore | | 693 | 617 | 76 |
| 1982-09-14 | vs SEA | 144 | W 5-2 | 83-61 | 1 | 16,826 | Bill Castro | Jim Beattie | Bill Castro | Jim Beattie | Bob Tufts | 698 | 619 | 79 |
| 1982-09-15 | vs SEA | 145 | W 5-4 | 84-61 | 1 | 17,151 | Larry Gura | Gaylord Perry | Dan Quisenberry | Bill Caudill | | 703 | 623 | 80 |
| 1982-09-16 | vs SEA | 146 | L 2-4 | 84-62 | 1 | 16,809 | Dennis Leonard | Floyd Bannister | Ed Vande Berg | Dennis Leonard | Mike Stanton | 705 | 627 | 78 |
| 1982-09-17 | @ MIN | 147 | L 4-5 | 84-63 | 1 | 7,201 | Paul Splittorff | Brad Havens | Brad Havens | Paul Splittorff | Ron Davis | 709 | 632 | 77 |
| 1982-09-18 | @ MIN | 148 | L 5-11 | 84-64 | 1 | 8,394 | Vida Blue | Albert Williams | Albert Williams | Vida Blue | | 714 | 643 | 71 |
| 1982-09-19 | @ MIN | 149 | L 4-9 | 84-65 | 1 | 7,255 | Bill Castro | Jack O'Connor | Jack O'Connor | Bill Castro | | 718 | 652 | 66 |
| 1982-09-20 | @ CAL | 150 | L 2-3 | 84-66 | 2 | 42,322 | Larry Gura | Geoff Zahn | Geoff Zahn | Larry Gura | Luis Sanchez | 720 | 655 | 65 |
| 1982-09-21 | @ CAL | 151 | L 1-2 | 84-67 | 2 | 52,415 | Dennis Leonard | Ken Forsch | Ken Forsch | Dan Quisenberry | | 721 | 657 | 64 |
| 1982-09-22 | @ CAL | 152 | L 5-8 | 84-68 | 2 | 51,273 | Vida Blue | Tommy John | Tommy John | Vida Blue | Dave Goltz | 726 | 665 | 61 |
| 1982-09-24 | @ OAK | 153 | W 7-4 | 85-68 | 2 | 16,611 | Larry Gura | Chris Codiroli | Larry Gura | Chris Codiroli | | 733 | 669 | 64 |
| 1982-09-25 | @ OAK | 154 | L 3-10 | 85-69 | 2 | 16,913 | Dennis Leonard | Brian Kingman | Tom Underwood | Dennis Leonard | | 736 | 679 | 57 |
| 1982-09-26 | @ OAK | 155 | L 4-5 | 85-70 | 2 | 26,272 | Bill Castro | Matt Keough | Dave Beard | Dan Quisenberry | | 740 | 684 | 56 |
| 1982-09-27 | vs CAL | 156 | L 2-3 | 85-71 | 2 | 38,278 | Vida Blue | Tommy John | Tommy John | Vida Blue | Luis Sanchez | 742 | 687 | 55 |
| 1982-09-28 | vs CAL | 157 | W 5-4 | 86-71 | 2 | 30,454 | Larry Gura | Mike Witt | Mike Armstrong | Dave Goltz | Dan Quisenberry | 747 | 691 | 56 |
| 1982-09-29 | vs CAL | 158 | W 6-5 | 87-71 | 2 | 26,502 | Dennis Leonard | Bruce Kison | Bob Tufts | Luis Sanchez | Dan Quisenberry | 753 | 696 | 57 |
| 1982-09-30 | vs OAK | 159 | W 11-4 | 88-71 | 2 | 18,676 | Paul Splittorff | Mike Norris | Paul Splittorff | Mike Norris | Mike Armstrong | 764 | 700 | 64 |
| 1982-10-01 | vs OAK | 160 | W 12-7 | 89-71 | 2 | 26,369 | Bill Castro | Brian Kingman | Bill Castro | Brian Kingman | Bob Tufts | 776 | 707 | 69 |
| 1982-10-02 | vs OAK | 161 | W 5-4 | 90-71 | 2 | 23,787 | Vida Blue | Matt Keough | Dan Quisenberry | Tom Underwood | | 781 | 711 | 70 |
| 1982-10-03 | vs OAK | 162 | L 3-6 | 90-72 | 2 | 24,488 | Larry Gura | Tim Conroy | Brian Kingman | Larry Gura | Dave Beard | 784 | 717 | 67 |