| 1982-04-06 | vs SLN | 1 | L 3-14 | - | | 33,521 | Nolan Ryan | Bob Forsch | Bob Forsch | Nolan Ryan | | 3 | 14 | -11 |
| 1982-04-07 | vs SLN | 2 | W 3-2 | - | | 18,467 | Joe Niekro | John Martin | Joe Niekro | John Martin | Joe Sambito | 6 | 16 | -10 |
| 1982-04-08 | vs SLN | 3 | W 1-0 | - | | 23,868 | Bob Knepper | Joaquin Andujar | Bob Knepper | Joaquin Andujar | Dave Smith | 7 | 16 | -9 |
| 1982-04-09 | @ ATL | 4 | L 2-6 | - | | 33,133 | Don Sutton | Tommy Boggs | Tommy Boggs | Don Sutton | Al Hrabosky | 9 | 22 | -13 |
| 1982-04-10 | @ ATL | 5 | L 6-8 | - | | 10,885 | Vern Ruhle | Steve Bedrosian | Larry McWilliams | Vern Ruhle | Rick Camp | 15 | 30 | -15 |
| 1982-04-11 | @ ATL | 6 | L 0-5 | - | | 11,322 | Nolan Ryan | Rick Mahler | Rick Mahler | Nolan Ryan | | 15 | 35 | -20 |
| 1982-04-12 | vs LAN | 7 | W 2-1 | - | | 21,226 | Joe Niekro | Jerry Reuss | Mike LaCoss | Dave Stewart | | 17 | 36 | -19 |
| 1982-04-13 | vs LAN | 8 | L 5-9 | - | | 20,736 | Bob Knepper | Bob Welch | Bob Welch | Bob Knepper | | 22 | 45 | -23 |
| 1982-04-14 | vs LAN | 9 | W 2-1 | - | | 25,562 | Don Sutton | Burt Hooton | Don Sutton | Burt Hooton | Joe Sambito | 24 | 46 | -22 |
| 1982-04-16 | vs ATL | 10 | L 3-5 | - | | 26,513 | Nolan Ryan | Rick Mahler | Larry McWilliams | Nolan Ryan | Rick Camp | 27 | 51 | -24 |
| 1982-04-17 | vs ATL | 11 | L 1-2 | - | | 33,688 | Joe Niekro | Bob Walk | Preston Hanna | Joe Niekro | Gene Garber | 28 | 53 | -25 |
| 1982-04-18 | vs ATL | 12 | L 5-6 | - | | 29,166 | Bob Knepper | Joe Cowley | Al Hrabosky | Dave Smith | Rick Camp | 33 | 59 | -26 |
| 1982-04-19 | @ LAN | 13 | W 6-4 | - | | 39,356 | Don Sutton | Burt Hooton | Don Sutton | Terry Forster | Joe Sambito | 39 | 63 | -24 |
| 1982-04-20 | @ LAN | 14 | L 2-10 | - | | 44,876 | Vern Ruhle | Fernando Valenzuela | Fernando Valenzuela | Vern Ruhle | | 41 | 73 | -32 |
| 1982-04-21 | @ LAN | 15 | L 0-6 | - | | 41,595 | Nolan Ryan | Jerry Reuss | Jerry Reuss | Nolan Ryan | | 41 | 79 | -38 |
| 1982-04-23 | vs CIN | 16 | W 7-3 | - | | 23,452 | Joe Niekro | Tom Seaver | Joe Niekro | Tom Seaver | | 48 | 82 | -34 |
| 1982-04-24 | vs CIN | 17 | L 2-3 | - | | 32,525 | Bob Knepper | Frank Pastore | Frank Pastore | Bob Knepper | Tom Hume | 50 | 85 | -35 |
| 1982-04-25 | vs CIN | 18 | L 3-4 | - | | 20,270 | Don Sutton | Mario Soto | Bob Shirley | Randy Moffitt | Tom Hume | 53 | 89 | -36 |
| 1982-04-26 | @ SLN | 19 | W 6-2 | - | | 24,295 | Nolan Ryan | John Martin | Nolan Ryan | John Martin | | 59 | 91 | -32 |
| 1982-04-27 | @ SLN | 20 | W 3-0 | - | | 14,368 | Vern Ruhle | Steve Mura | Vern Ruhle | Steve Mura | Joe Sambito | 62 | 91 | -29 |
| 1982-04-28 | @ SLN | 21 | L 4-5 | - | | 15,757 | Joe Niekro | Bob Forsch | Bob Forsch | Dave Smith | Bruce Sutter | 66 | 96 | -30 |
| 1982-04-29 | @ PIT | 22 | L 6-9 | - | | 4,716 | Bob Knepper | Don Robinson | Enrique Romo | Mike LaCoss | Rod Scurry | 72 | 105 | -33 |
| 1982-04-30 | @ PIT | 23 | W 4-3 | - | | 8,768 | Don Sutton | Rick Rhoden | Don Sutton | Rick Rhoden | Dave Smith | 76 | 108 | -32 |
| 1982-05-01 | @ PIT | 24 | W 6-3 | - | | 19,626 | Nolan Ryan | John Candelaria | Nolan Ryan | Paul Moskau | Dave Smith | 82 | 111 | -29 |
| 1982-05-02 | @ PIT | 25 | W 6-2 | - | | 11,116 | Joe Niekro | Tom Griffin | Joe Niekro | Tom Griffin | Randy Moffitt | 88 | 113 | -25 |
| 1982-05-04 | @ CIN | 26 | L 2-5 | - | | 15,119 | Bob Knepper | Tom Seaver | Tom Seaver | Bob Knepper | Tom Hume | 90 | 118 | -28 |
| 1982-05-05 | @ CIN | 27 | W 8-7 | - | | 17,691 | Don Sutton | Frank Pastore | Don Sutton | Frank Pastore | Dave Smith | 98 | 125 | -27 |
| 1982-05-07 | @ CHN | 28 | L 6-12 | - | | 6,404 | Nolan Ryan | Randy Martz | Randy Martz | Nolan Ryan | | 104 | 137 | -33 |
| 1982-05-08 | @ CHN | 29 | L 2-3 | - | | 22,151 | Joe Niekro | Dickie Noles | Dickie Noles | Joe Niekro | Bill Campbell | 106 | 140 | -34 |
| 1982-05-09 | @ CHN | 30 | L 3-6 | - | | 14,343 | Bob Knepper | Fergie Jenkins | Guillermo Hernandez | Randy Moffitt | | 109 | 146 | -37 |
| 1982-05-10 | vs PIT | 31 | W 7-3 | - | | 16,141 | Don Sutton | Rick Rhoden | Don Sutton | Rick Rhoden | | 116 | 149 | -33 |
| 1982-05-11 | vs PIT | 32 | W 4-2 | - | | 17,893 | Nolan Ryan | Tom Griffin | Nolan Ryan | Tom Griffin | Dave Smith | 120 | 151 | -31 |
| 1982-05-13 | vs CHN | 33 | L 0-5 | - | | 13,534 | Joe Niekro | Allen Ripley | Allen Ripley | Joe Niekro | Lee Smith | 120 | 156 | -36 |
| 1982-05-14 | vs CHN | 34 | L 3-6 | - | | 19,193 | Bob Knepper | Dickie Noles | Dickie Noles | Bob Knepper | Guillermo Hernandez | 123 | 162 | -39 |
| 1982-05-15 | vs CHN | 35 | W 4-1 | - | | 43,543 | Don Sutton | Fergie Jenkins | Don Sutton | Fergie Jenkins | | 127 | 163 | -36 |
| 1982-05-16 | vs CHN | 36 | L 1-2 | - | | 21,267 | Nolan Ryan | Doug Bird | Doug Bird | Nolan Ryan | Guillermo Hernandez | 128 | 165 | -37 |
| 1982-05-17 | @ PHI | 37 | W 8-1 | - | | 23,734 | Vern Ruhle | Ron Reed | Vern Ruhle | Ron Reed | | 136 | 166 | -30 |
| 1982-05-18 | @ PHI | 38 | W 2-1 | - | | 23,869 | Joe Niekro | Dick Ruthven | Dave Smith | Ed Farmer | | 138 | 167 | -29 |
| 1982-05-19 | @ PHI | 39 | W 5-3 | - | | 20,007 | Bob Knepper | Steve Carlton | Bob Knepper | Steve Carlton | Dave Smith | 143 | 170 | -27 |
| 1982-05-21 | vs NYN | 40 | W 5-1 | - | | 22,383 | Don Sutton | Mike Scott | Don Sutton | Mike Scott | | 148 | 171 | -23 |
| 1982-05-22 | vs NYN | 41 | L 5-6 | - | | 33,253 | Nolan Ryan | Pete Falcone | Neil Allen | Randy Moffitt | | 153 | 177 | -24 |
| 1982-05-23 | vs NYN | 42 | L 0-2 | - | | 26,624 | Joe Niekro | Randy Jones | Randy Jones | Joe Niekro | | 153 | 179 | -26 |
| 1982-05-24 | vs MON | 43 | L 0-2 | - | | 14,823 | Bob Knepper | Bill Gullickson | Bill Gullickson | Bob Knepper | Woodie Fryman | 153 | 181 | -28 |
| 1982-05-25 | vs MON | 44 | L 1-6 | - | | 15,770 | Vern Ruhle | David Palmer | David Palmer | Vern Ruhle | Bryn Smith | 154 | 187 | -33 |
| 1982-05-26 | vs MON | 45 | L 0-4 | - | | 15,834 | Don Sutton | Charlie Lea | Charlie Lea | Frank LaCorte | | 154 | 191 | -37 |
| 1982-05-28 | @ NYN | 46 | W 8-3 | - | | 15,273 | Nolan Ryan | Randy Jones | Nolan Ryan | Randy Jones | Dave Smith | 162 | 194 | -32 |
| 1982-05-29 | @ NYN | 47 | W 5-2 | - | | 34,184 | Joe Niekro | Pat Zachry | Joe Niekro | Pat Zachry | | 167 | 196 | -29 |
| 1982-05-30 | @ NYN | 48 | L 5-9 | - | | 19,544 | Bob Knepper | Mike Scott | Mike Scott | Bob Knepper | Neil Allen | 172 | 205 | -33 |
| 1982-05-31 | @ MON | 49 | L 0-10 | - | | 22,365 | Don Sutton | Charlie Lea | Charlie Lea | Don Sutton | | 172 | 215 | -43 |
| 1982-06-02 | @ MON | 50 | W 6-4 | - | | 18,694 | Nolan Ryan | Scott Sanderson | Nolan Ryan | Scott Sanderson | | 178 | 219 | -41 |
| 1982-06-04 | vs PHI | 51 | W 8-3 | - | | 23,362 | Joe Niekro | Steve Carlton | Vern Ruhle | Ed Farmer | | 186 | 222 | -36 |
| 1982-06-05 | vs PHI | 52 | L 3-5 | - | | 35,315 | Bob Knepper | Larry Christenson | Sparky Lyle | Dave Smith | | 189 | 227 | -38 |
| 1982-06-06 | vs PHI | 53 | W 7-6 | - | | 21,374 | Don Sutton | Mike Krukow | Vern Ruhle | Warren Brusstar | | 196 | 233 | -37 |
| 1982-06-08 | @ SFN | 54 | L 3-7 | - | | 9,426 | Nolan Ryan | Atlee Hammaker | Atlee Hammaker | Nolan Ryan | Gary Lavelle | 199 | 240 | -41 |
| 1982-06-09 | @ SFN | 55 | W 6-1 | - | | 7,217 | Joe Niekro | Bill Laskey | Joe Niekro | Bill Laskey | | 205 | 241 | -36 |
| 1982-06-10 | @ SDN | 56 | L 0-5 | - | | 21,728 | Bob Knepper | John Curtis | John Curtis | Bob Knepper | | 205 | 246 | -41 |
| 1982-06-11 | @ SDN | 57 | L 2-6 | - | | 18,744 | Don Sutton | Tim Lollar | Tim Lollar | Don Sutton | | 207 | 252 | -45 |
| 1982-06-12 | @ SDN | 58 | L 0-4 | - | | 29,557 | Vern Ruhle | Chris Welsh | Chris Welsh | Vern Ruhle | | 207 | 256 | -49 |
| 1982-06-13 | @ SDN | 59 | L 4-5 | - | | 19,488 | Nolan Ryan | John Montefusco | John Montefusco | Nolan Ryan | Gary Lucas | 211 | 261 | -50 |
| 1982-06-14 | vs ATL | 60 | W 9-0 | - | | 17,353 | Joe Niekro | Rick Mahler | Joe Niekro | Rick Mahler | | 220 | 261 | -41 |
| 1982-06-15 | vs ATL | 61 | L 0-7 | - | | 17,837 | Bob Knepper | Bob Walk | Bob Walk | Bob Knepper | | 220 | 268 | -48 |
| 1982-06-16 | vs ATL | 62 | L 4-5 | - | | 18,673 | Don Sutton | Phil Niekro | Gene Garber | George Cappuzzello | | 224 | 273 | -49 |
| 1982-06-18 | vs SDN | 63 | W 7-2 | - | | 16,488 | Nolan Ryan | Chris Welsh | Nolan Ryan | Chris Welsh | | 231 | 275 | -44 |
| 1982-06-19 | vs SDN | 64 | L 1-7 | - | | 27,441 | Joe Niekro | John Montefusco | John Montefusco | Joe Niekro | Gary Lucas | 232 | 282 | -50 |
| 1982-06-20 | vs SDN | 65 | W 8-4 | - | | 15,021 | Bob Knepper | Juan Eichelberger | Mike LaCoss | Juan Eichelberger | | 240 | 286 | -46 |
| 1982-06-21 | vs SDN | 66 | L 4-7 | - | | 13,427 | Don Sutton | John Curtis | Eric Show | Mike LaCoss | | 244 | 293 | -49 |
| 1982-06-22 | vs SFN | 67 | W 2-0 | - | | 12,966 | Vern Ruhle | Rich Gale | Vern Ruhle | Rich Gale | | 246 | 293 | -47 |
| 1982-06-23 | vs SFN | 68 | L 8-9 | - | | 14,295 | Nolan Ryan | Renie Martin | Fred Breining | Frank LaCorte | Greg Minton | 254 | 302 | -48 |
| 1982-06-24 | vs SFN | 69 | L 3-4 | - | | 13,782 | Joe Niekro | Atlee Hammaker | Atlee Hammaker | Joe Niekro | | 257 | 306 | -49 |
| 1982-06-25 | vs LAN | 70 | W 7-5 | - | | 25,992 | Dave Smith | Bob Welch | Mike LaCoss | Terry Forster | Bert Roberge | 264 | 311 | -47 |
| 1982-06-26 | vs LAN | 71 | L 1-4 | - | | 25,197 | Don Sutton | Dave Stewart | Dave Stewart | Don Sutton | Steve Howe | 265 | 315 | -50 |
| 1982-06-27 | vs LAN | 72 | L 3-7 | - | | 28,292 | Vern Ruhle | Vicente Romo | Terry Forster | Vern Ruhle | | 268 | 322 | -54 |
| 1982-06-28 | @ ATL | 73 | W 6-2 | - | | 12,837 | Nolan Ryan | Rick Mahler | Nolan Ryan | Rick Mahler | | 274 | 324 | -50 |
| 1982-06-29 | @ ATL | 74 | L 5-6 | - | | 10,483 | Joe Niekro | Bob Walk | Steve Bedrosian | Mike LaCoss | | 279 | 330 | -51 |
| 1982-06-30 | @ ATL | 75 | L 4-5 | - | | 10,308 | Bob Knepper | Phil Niekro | Carlos Diaz | Bob Knepper | | 283 | 335 | -52 |
| 1982-07-02 | @ LAN | 76 | W 4-1 | - | | 43,364 | Don Sutton | Vicente Romo | Don Sutton | Vicente Romo | Frank LaCorte | 287 | 336 | -49 |
| 1982-07-03 | @ LAN | 77 | L 4-5 | - | | 51,238 | Vern Ruhle | Fernando Valenzuela | Fernando Valenzuela | Bert Roberge | | 291 | 341 | -50 |
| 1982-07-04 | @ LAN | 78 | W 3-0 | - | | 41,450 | Nolan Ryan | Jerry Reuss | Nolan Ryan | Jerry Reuss | | 294 | 341 | -47 |
| 1982-07-05 | @ PIT | 79 | W 6-4 | - | | 10,437 | Joe Niekro | Ross Baumgarten | Joe Niekro | Ross Baumgarten | | 300 | 345 | -45 |
| 1982-07-06 | @ PIT | 80 | L 0-1 | - | | 8,850 | Bob Knepper | Larry McWilliams | Larry McWilliams | Bob Knepper | | 300 | 346 | -46 |
| 1982-07-07 | vs CHN | 81 | W 5-1 | - | | 17,105 | Don Sutton | Allen Ripley | Don Sutton | Allen Ripley | | 305 | 347 | -42 |
| 1982-07-08 | vs CHN | 82 | L 3-5 | - | | 11,023 | Vern Ruhle | Tom Filer | Dick Tidrow | Vern Ruhle | Guillermo Hernandez | 308 | 352 | -44 |
| 1982-07-09 | vs SLN | 83 | L 2-3 | - | | 21,178 | Nolan Ryan | Dave LaPoint | Dave LaPoint | Nolan Ryan | Jim Kaat | 310 | 355 | -45 |
| 1982-07-10 | vs SLN | 84 | W 4-2 | - | | 31,000 | Joe Niekro | Bob Forsch | Joe Niekro | Bob Forsch | | 314 | 357 | -43 |
| 1982-07-11 | vs SLN | 85 | W 4-2 | - | | 20,736 | Bob Knepper | Joaquin Andujar | Bob Knepper | Joaquin Andujar | | 318 | 359 | -41 |
| 1982-07-15 | vs PIT | 86 | L 1-5 | - | | 17,662 | Don Sutton | John Candelaria | John Candelaria | Don Sutton | Rod Scurry | 319 | 364 | -45 |
| 1982-07-16 | vs PIT | 87 | W 4-2 | - | | 19,037 | Nolan Ryan | Larry McWilliams | Nolan Ryan | Larry McWilliams | | 323 | 366 | -43 |
| 1982-07-17 | vs PIT | 88 | W 4-3 | - | | 28,672 | Joe Niekro | Rick Rhoden | Joe Niekro | Kent Tekulve | | 327 | 369 | -42 |
| 1982-07-18 | vs PIT | 89 | W 4-2 | - | | 19,218 | Bob Knepper | Don Robinson | Bob Knepper | Don Robinson | | 331 | 371 | -40 |
| 1982-07-19 | @ CHN | 90 | L 5-6 | - | | 13,538 | Vern Ruhle | Tom Filer | Lee Smith | Frank LaCorte | | 336 | 377 | -41 |
| 1982-07-20 | @ CHN | 91 | L 3-5 | - | | 16,284 | Don Sutton | Fergie Jenkins | Guillermo Hernandez | Don Sutton | Dick Tidrow | 339 | 382 | -43 |
| 1982-07-21 | @ CHN | 92 | W 2-1 | - | | 13,264 | Nolan Ryan | Allen Ripley | Nolan Ryan | Allen Ripley | Frank LaCorte | 341 | 383 | -42 |
| 1982-07-23 | @ SLN | 93 | L 2-6 | - | | 30,832 | Joe Niekro | Joaquin Andujar | Joaquin Andujar | Joe Niekro | | 343 | 389 | -46 |
| 1982-07-24 | @ SLN | 94 | L 1-5 | - | | 22,462 | Bob Knepper | Bob Forsch | Bob Forsch | Bob Knepper | | 344 | 394 | -50 |
| 1982-07-25 | @ SLN | 95 | L 3-4 | - | | 36,043 | Don Sutton | Dave LaPoint | Bruce Sutter | Don Sutton | | 347 | 398 | -51 |
| 1982-07-27 | vs CIN | 96 | W 3-2 | - | | 19,009 | Nolan Ryan | Charlie Leibrandt | Nolan Ryan | Charlie Leibrandt | | 350 | 400 | -50 |
| 1982-07-28 | vs CIN | 97 | W 4-2 | - | | 16,271 | Joe Niekro | Mario Soto | Joe Niekro | Mario Soto | | 354 | 402 | -48 |
| 1982-07-29 | vs CIN | 98 | W 4-3 | - | | 17,261 | Bob Knepper | Frank Pastore | Randy Moffitt | Greg Harris | Frank LaCorte | 358 | 405 | -47 |
| 1982-07-30 | vs SFN | 99 | W 3-1 | - | | 17,407 | Don Sutton | Rich Gale | Don Sutton | Rich Gale | | 361 | 406 | -45 |
| 1982-07-31 | vs SFN | 100 | L 4-5 | - | | 0 | Vern Ruhle | Bill Laskey | Bill Laskey | Vern Ruhle | Greg Minton | 365 | 411 | -46 |
| 1982-07-31 | vs SFN | 101 | W 5-0 | - | | 28,190 | Mike LaCoss | Atlee Hammaker | Mike LaCoss | Atlee Hammaker | Frank LaCorte | 370 | 411 | -41 |
| 1982-08-01 | vs SFN | 102 | L 2-4 | - | | 20,108 | Nolan Ryan | Renie Martin | Greg Minton | Frank LaCorte | | 372 | 415 | -43 |
| 1982-08-02 | vs SDN | 103 | W 6-4 | - | | 13,302 | Joe Niekro | Andy Hawkins | Joe Niekro | Gary Lucas | Dave Smith | 378 | 419 | -41 |
| 1982-08-03 | vs SDN | 104 | W 7-6 | - | | 16,801 | Bob Knepper | Chris Welsh | Randy Moffitt | Luis DeLeon | | 385 | 425 | -40 |
| 1982-08-04 | vs SDN | 105 | L 2-5 | - | | 9,705 | Don Sutton | John Montefusco | John Montefusco | Don Sutton | | 387 | 430 | -43 |
| 1982-08-05 | @ SFN | 106 | L 2-5 | - | | 5,357 | Vern Ruhle | Bill Laskey | Bill Laskey | Vern Ruhle | Greg Minton | 389 | 435 | -46 |
| 1982-08-06 | @ SFN | 107 | L 6-7 | - | | 8,430 | Nolan Ryan | Atlee Hammaker | Gary Lavelle | Randy Moffitt | | 395 | 442 | -47 |
| 1982-08-07 | @ SFN | 108 | L 2-9 | - | | 11,780 | Joe Niekro | Renie Martin | Renie Martin | Joe Niekro | | 397 | 451 | -54 |
| 1982-08-08 | @ SFN | 109 | L 2-3 | - | | 0 | Bob Knepper | Rich Gale | Fred Breining | Bob Knepper | | 399 | 454 | -55 |
| 1982-08-08 | @ SFN | 110 | L 3-8 | - | | 22,937 | Mike LaCoss | Alan Fowlkes | Gary Lavelle | Mike LaCoss | | 402 | 462 | -60 |
| 1982-08-09 | @ SDN | 111 | W 4-3 | - | | 9,288 | Don Sutton | John Montefusco | Don Sutton | John Montefusco | Dave Smith | 406 | 465 | -59 |
| 1982-08-10 | @ SDN | 112 | W 4-1 | - | | 11,808 | Vern Ruhle | Tim Lollar | Vern Ruhle | Tim Lollar | Randy Moffitt | 410 | 466 | -56 |
| 1982-08-11 | @ SDN | 113 | W 3-0 | - | | 10,130 | Nolan Ryan | Eric Show | Nolan Ryan | Eric Show | | 413 | 466 | -53 |
| 1982-08-13 | @ CIN | 114 | L 0-3 | - | | 16,053 | Joe Niekro | Frank Pastore | Frank Pastore | Joe Niekro | | 413 | 469 | -56 |
| 1982-08-14 | @ CIN | 115 | W 2-0 | - | | 18,105 | Bob Knepper | Bruce Berenyi | Bob Knepper | Bruce Berenyi | Randy Moffitt | 415 | 469 | -54 |
| 1982-08-15 | @ CIN | 116 | W 7-3 | - | | 18,944 | Don Sutton | Tom Seaver | Don Sutton | Tom Seaver | Bert Roberge | 422 | 472 | -50 |
| 1982-08-16 | @ CIN | 117 | L 2-3 | - | | 11,368 | Nolan Ryan | Bob Shirley | Jim Kern | Dave Smith | | 424 | 475 | -51 |
| 1982-08-17 | vs PHI | 118 | W 2-0 | - | | 19,725 | Vern Ruhle | Larry Christenson | Vern Ruhle | Larry Christenson | | 426 | 475 | -49 |
| 1982-08-18 | vs PHI | 119 | L 3-5 | - | | 18,449 | Joe Niekro | Mike Krukow | Tug McGraw | Mike LaCoss | | 429 | 480 | -51 |
| 1982-08-19 | vs PHI | 120 | W 7-6 | - | | 18,797 | Bob Knepper | Steve Carlton | Dave Smith | Sid Monge | | 436 | 486 | -50 |
| 1982-08-20 | vs MON | 121 | W 4-3 | - | | 18,552 | Don Sutton | Steve Rogers | Bert Roberge | Jeff Reardon | | 440 | 489 | -49 |
| 1982-08-21 | vs MON | 122 | W 5-3 | - | | 17,329 | Nolan Ryan | Ray Burris | Nolan Ryan | Ray Burris | | 445 | 492 | -47 |
| 1982-08-22 | vs MON | 123 | L 0-5 | - | | 13,774 | Vern Ruhle | Charlie Lea | Charlie Lea | Vern Ruhle | | 445 | 497 | -52 |
| 1982-08-23 | vs NYN | 124 | W 2-0 | - | | 10,683 | Joe Niekro | Pat Zachry | Joe Niekro | Pat Zachry | | 447 | 497 | -50 |
| 1982-08-24 | vs NYN | 125 | W 5-4 | - | | 21,108 | Bob Knepper | Craig Swan | Dave Smith | Mike Scott | | 452 | 501 | -49 |
| 1982-08-25 | vs NYN | 126 | W 5-4 | - | | 9,651 | Don Sutton | Ed Lynch | Don Sutton | Ed Lynch | Bert Roberge | 457 | 505 | -48 |
| 1982-08-26 | @ MON | 127 | L 2-3 | - | | 0 | Nolan Ryan | Bill Gullickson | Jeff Reardon | Bert Roberge | | 459 | 508 | -49 |
| 1982-08-26 | @ MON | 128 | L 3-5 | - | | 40,128 | Vern Ruhle | Ray Burris | Jeff Reardon | Vern Ruhle | Woodie Fryman | 462 | 513 | -51 |
| 1982-08-28 | @ MON | 129 | W 2-0 | - | | 38,165 | Joe Niekro | Charlie Lea | Joe Niekro | Charlie Lea | | 464 | 513 | -49 |
| 1982-08-29 | @ MON | 130 | L 3-5 | - | | 38,336 | Bob Knepper | Scott Sanderson | Scott Sanderson | Bob Knepper | Bryn Smith | 467 | 518 | -51 |
| 1982-08-30 | @ NYN | 131 | W 4-2 | - | | 8,497 | Mike LaCoss | Craig Swan | Frank LaCorte | Craig Swan | Dave Smith | 471 | 520 | -49 |
| 1982-08-31 | @ NYN | 132 | W 4-0 | - | | 9,577 | Nolan Ryan | Ed Lynch | Nolan Ryan | Ed Lynch | | 475 | 520 | -45 |
| 1982-09-01 | @ NYN | 133 | L 1-5 | - | | 4,488 | Vern Ruhle | Pete Falcone | Pete Falcone | Vern Ruhle | | 476 | 525 | -49 |
| 1982-09-03 | @ PHI | 134 | L 1-2 | - | | 28,320 | Joe Niekro | Steve Carlton | Steve Carlton | Joe Niekro | | 477 | 527 | -50 |
| 1982-09-04 | @ PHI | 135 | L 2-4 | - | | 35,747 | Bob Knepper | Dick Ruthven | Sid Monge | Bob Knepper | Ron Reed | 479 | 531 | -52 |
| 1982-09-05 | @ PHI | 136 | L 3-4 | - | | 33,983 | Nolan Ryan | Marty Bystrom | Porfi Altamirano | Nolan Ryan | Ron Reed | 482 | 535 | -53 |
| 1982-09-06 | vs SDN | 137 | L 2-4 | - | | 9,244 | Vern Ruhle | Chris Welsh | Chris Welsh | Vern Ruhle | | 484 | 539 | -55 |
| 1982-09-07 | vs SDN | 138 | W 4-3 | - | | 11,085 | Frank DiPino | Juan Eichelberger | Frank DiPino | Juan Eichelberger | Danny Boone | 488 | 542 | -54 |
| 1982-09-08 | vs SFN | 139 | W 8-1 | - | | 9,880 | Joe Niekro | Atlee Hammaker | Joe Niekro | Atlee Hammaker | | 496 | 543 | -47 |
| 1982-09-09 | vs SFN | 140 | L 1-5 | - | | 3,770 | Mike LaCoss | Renie Martin | Renie Martin | Mike LaCoss | Greg Minton | 497 | 548 | -51 |
| 1982-09-10 | vs LAN | 141 | L 2-3 | - | | 19,018 | Nolan Ryan | Burt Hooton | Steve Howe | Nolan Ryan | Tom Niedenfuer | 499 | 551 | -52 |
| 1982-09-11 | vs LAN | 142 | L 3-5 | - | | 17,981 | Vern Ruhle | Jerry Reuss | Jerry Reuss | Vern Ruhle | Steve Howe | 502 | 556 | -54 |
| 1982-09-12 | vs LAN | 143 | L 3-7 | - | | 15,014 | Frank DiPino | Ricky Wright | Dave Stewart | Frank DiPino | | 505 | 563 | -58 |
| 1982-09-13 | @ ATL | 144 | W 5-3 | - | | 7,556 | Joe Niekro | Phil Niekro | Joe Niekro | Phil Niekro | | 510 | 566 | -56 |
| 1982-09-14 | @ ATL | 145 | W 4-0 | - | | 9,331 | Mike LaCoss | Rick Mahler | Mike LaCoss | Rick Mahler | Frank LaCorte | 514 | 566 | -52 |
| 1982-09-15 | @ ATL | 146 | W 5-4 | - | | 11,422 | Nolan Ryan | Tommy Boggs | Nolan Ryan | Tommy Boggs | Dave Smith | 519 | 570 | -51 |
| 1982-09-17 | @ LAN | 147 | L 2-9 | - | | 45,932 | Frank DiPino | Jerry Reuss | Jerry Reuss | Frank DiPino | | 521 | 579 | -58 |
| 1982-09-18 | @ LAN | 148 | W 2-0 | - | | 48,567 | Joe Niekro | Bob Welch | Joe Niekro | Bob Welch | | 523 | 579 | -56 |
| 1982-09-19 | @ LAN | 149 | L 4-5 | - | | 48,110 | Mike LaCoss | Fernando Valenzuela | Fernando Valenzuela | Frank LaCorte | | 527 | 584 | -57 |
| 1982-09-20 | vs ATL | 150 | W 4-3 | - | | 12,634 | Nolan Ryan | Tommy Boggs | Dave Smith | Gene Garber | | 531 | 587 | -56 |
| 1982-09-21 | vs ATL | 151 | W 5-3 | - | | 15,374 | Vern Ruhle | Rick Camp | Vern Ruhle | Rick Camp | Bob Knepper | 536 | 590 | -54 |
| 1982-09-22 | vs ATL | 152 | W 3-2 | - | | 16,821 | Frank DiPino | Phil Niekro | Dave Smith | Gene Garber | Frank LaCorte | 539 | 592 | -53 |
| 1982-09-24 | @ CIN | 153 | L 0-2 | - | | 6,666 | Joe Niekro | Bruce Berenyi | Bruce Berenyi | Joe Niekro | | 539 | 594 | -55 |
| 1982-09-25 | @ CIN | 154 | W 3-1 | - | | 8,004 | Mike LaCoss | Bill Scherrer | Mike LaCoss | Bill Scherrer | Frank LaCorte | 542 | 595 | -53 |
| 1982-09-26 | @ CIN | 155 | W 4-0 | - | | 25,125 | Nolan Ryan | Bob Shirley | Nolan Ryan | Bob Shirley | | 546 | 595 | -49 |
| 1982-09-27 | @ SDN | 156 | W 7-3 | - | | 9,021 | Frank DiPino | John Montefusco | Vern Ruhle | Chris Welsh | | 553 | 598 | -45 |
| 1982-09-28 | @ SDN | 157 | L 0-3 | - | | 4,615 | Bob Knepper | Tim Lollar | Tim Lollar | Bob Knepper | Luis DeLeon | 553 | 601 | -48 |
| 1982-09-29 | @ SFN | 158 | L 1-6 | - | | 8,117 | Joe Niekro | Atlee Hammaker | Atlee Hammaker | Joe Niekro | Gary Lavelle | 554 | 607 | -53 |
| 1982-09-30 | @ SFN | 159 | L 6-7 | - | | 13,082 | Mike LaCoss | Jim Barr | Gary Lavelle | Danny Boone | | 560 | 614 | -54 |
| 1982-10-01 | vs CIN | 160 | L 2-4 | - | | 13,272 | Nolan Ryan | Bob Shirley | Bob Shirley | Nolan Ryan | Joe Price | 562 | 618 | -56 |
| 1982-10-02 | vs CIN | 161 | W 4-2 | - | | 13,811 | Frank DiPino | Mario Soto | Frank DiPino | Mario Soto | Vern Ruhle | 566 | 620 | -54 |
| 1982-10-03 | vs CIN | 162 | W 3-0 | - | | 14,672 | Joe Niekro | Frank Pastore | Joe Niekro | Frank Pastore | | 569 | 620 | -51 |