1981 HOUSTON ASTROS
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Level: MLB
Location: Houston,TX
Team Record: 61-49 .555
Result: th in National League - West Division
Manager(s): Bill Virdon
General Manager: Al Rosen
Stadium: Astrodome
Attendance: 1,321,282
Playoffs: Lost in 1st Round (Dodgers)
Houston Astros affiliate history
Team Record: 61-49 .555
Result: th in National League - West Division
Manager(s): Bill Virdon
General Manager: Al Rosen
Stadium: Astrodome
Attendance: 1,321,282
Playoffs: Lost in 1st Round (Dodgers)
Houston Astros affiliate history
Oldest Player: Joe Niekro (36)
Youngest Player: Bert Pena (21)
Longest Tenure: Cesar Cedeno (12)
Top Hitter: Jose Cruz (15)
Top Pitcher: Don Sutton (4)
Top Draft Pick: Curtis Burke (#75)
Roster Continuity: 77.87%
Youngest Player: Bert Pena (21)
Longest Tenure: Cesar Cedeno (12)
Top Hitter: Jose Cruz (15)
Top Pitcher: Don Sutton (4)
Top Draft Pick: Curtis Burke (#75)
Roster Continuity: 77.87%
National League Standings
| West | W | L | Pct | GB |
| Cincinnati | 66 | 42 | .611 | -- |
| LA Dodgers | 63 | 47 | .573 | 4.0 |
| Houston | 61 | 49 | .555 | 6.0 |
| SF Giants | 56 | 55 | .505 | 11.5 |
| Atlanta | 50 | 56 | .472 | 15.0 |
| San Diego | 41 | 69 | .373 | 26.0 |
PITCHING STATISTICS
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 1981-04-09 | Joe Niekro | R | 36 | L 0-2 | @ LAN | 1 | 278 | L | 7.0 | 8 | 2 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 0-1 | 2.57 | 1.29 |
| 1981-04-11 | Don Sutton | R | 36 | L 4-7 | @ LAN | 1 | 518 | L | 4.0 | 8 | 6 | 6 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 0-1 | 13.50 | 2.75 |
| 1981-04-12 | Vern Ruhle | R | 30 | L 2-3 | @ LAN | 1 | 119 | L | 5.0 | 7 | 3 | 3 | 1 | 0 | 4 | 0 | 0 | 0 | -- | 0-1 | 5.40 | 1.40 |
| 1981-04-13 | Bob Knepper | L | 27 | W 1-2 | vs ATL | 1 | 134 | - | 3.0 | 5 | 1 | 1 | 0 | 0 | 4 | 0 | 0 | 0 | -- | 0-0 | 3.00 | 1.67 |
| 1981-04-14 | Joe Niekro | R | 36 | L 8-2 | vs ATL | 2 | 279 | W | 9.0 | 7 | 2 | 2 | 0 | 2 | 4 | 0 | 0 | 0 | -- | 1-1 | 2.25 | 1.13 |
| 1981-04-15 | Nolan Ryan | R | 34 | L 2-0 | vs ATL | 1 | 398 | W | 7.0 | 3 | 0 | 0 | 0 | 3 | 9 | 0 | 0 | 0 | -- | 1-0 | 0.00 | 0.86 |
| 1981-04-17 | Don Sutton | R | 36 | W 3-4 | vs PIT | 2 | 519 | L | 6.1 | 9 | 4 | 4 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 0-2 | 9.00 | 2.10 |
| 1981-04-18 | Vern Ruhle | R | 30 | W 3-6 | vs PIT | 2 | 120 | - | 8.0 | 3 | 1 | 1 | 1 | 0 | 5 | 0 | 0 | 0 | -- | 0-1 | 2.77 | 0.77 |
| 1981-04-19 | Joe Niekro | R | 36 | W 0-2 | vs PIT | 3 | 280 | L | 9.0 | 6 | 2 | 2 | 1 | 1 | 6 | 0 | 0 | 0 | -- | 1-2 | 2.16 | 1.00 |
| 1981-04-20 | Joaquin Andujar | R | 28 | W 2-5 | vs LAN | 1 | 101 | L | 5.2 | 6 | 3 | 3 | 0 | 5 | 4 | 0 | 0 | 0 | -- | 0-1 | 3.60 | 1.60 |
| 1981-04-21 | Bob Knepper | L | 27 | L 1-0 | vs LAN | 2 | 135 | W | 9.0 | 3 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | -- | 1-0 | 0.75 | 0.67 |
| 1981-04-22 | Don Sutton | R | 36 | W 0-1 | vs LAN | 3 | 520 | L | 7.0 | 6 | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | -- | 0-3 | 5.82 | 1.59 |
| 1981-04-23 | Vern Ruhle | R | 30 | W 4-5 | vs CIN | 3 | 121 | - | 7.1 | 5 | 3 | 3 | 0 | 3 | 4 | 0 | 0 | 0 | -- | 0-1 | 3.15 | 0.90 |
| 1981-04-24 | Joe Niekro | R | 36 | W 0-3 | vs CIN | 4 | 281 | L | 8.2 | 10 | 3 | 3 | 0 | 2 | 5 | 0 | 0 | 0 | -- | 1-3 | 2.38 | 1.09 |
| 1981-04-25 | Nolan Ryan | R | 34 | W 1-2 | vs CIN | 2 | 399 | L | 7.0 | 4 | 2 | 2 | 0 | 4 | 10 | 0 | 0 | 0 | -- | 1-1 | 1.29 | 1.00 |
| 1981-04-26 | Bob Knepper | L | 27 | L 1-0 | vs CIN | 3 | 136 | W | 9.0 | 8 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 2-0 | 0.43 | 0.81 |
| 1981-04-28 | Don Sutton | R | 36 | W 2-1 | @ ATL | 4 | 521 | W | 8.0 | 2 | 1 | 1 | 1 | 0 | 8 | 0 | 0 | 0 | -- | 1-3 | 4.32 | 1.16 |
| 1981-04-29 | Vern Ruhle | R | 30 | W 5-4 | @ ATL | 4 | 122 | - | 3.1 | 4 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 0-1 | 3.00 | 0.96 |
| 1981-04-30 | Joe Niekro | R | 36 | W 5-1 | @ ATL | 5 | 282 | W | 9.0 | 5 | 1 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 2-3 | 2.09 | 1.00 |
| 1981-05-01 | Nolan Ryan | R | 34 | W 5-3 | @ PIT | 3 | 400 | - | 5.0 | 7 | 3 | 3 | 0 | 3 | 1 | 0 | 0 | 0 | -- | 1-1 | 2.37 | 1.26 |
| 1981-05-02 | Bob Knepper | L | 27 | L 4-5 | @ PIT | 4 | 137 | - | 6.1 | 5 | 3 | 3 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 2-0 | 1.33 | 0.93 |
| 1981-05-03 | Don Sutton | R | 36 | W 3-1 | @ PIT | 5 | 522 | W | 7.0 | 5 | 1 | 1 | 0 | 4 | 5 | 0 | 0 | 0 | -- | 2-3 | 3.66 | 1.19 |
| 1981-05-04 | Joaquin Andujar | R | 28 | W 5-4 | @ CHN | 2 | 102 | W | 5.1 | 7 | 1 | 1 | 1 | 1 | 8 | 0 | 0 | 0 | -- | 1-1 | 2.50 | 1.44 |
| 1981-05-05 | Joe Niekro | R | 36 | W 4-3 | @ CHN | 6 | 283 | - | 6.1 | 5 | 3 | 3 | 0 | 3 | 4 | 0 | 0 | 0 | -- | 2-3 | 2.39 | 1.04 |
| 1981-05-06 | Nolan Ryan | R | 34 | L 1-2 | @ CHN | 4 | 401 | - | 7.0 | 6 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 1-1 | 1.73 | 1.19 |
| 1981-05-07 | Bob Knepper | L | 27 | W 6-0 | @ CHN | 5 | 138 | W | 9.0 | 6 | 0 | 0 | 0 | 2 | 5 | 0 | 0 | 0 | -- | 3-0 | 1.00 | 0.92 |
| 1981-05-08 | Don Sutton | R | 36 | L 0-4 | @ CIN | 6 | 523 | L | 6.0 | 5 | 2 | 2 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 2-4 | 3.55 | 1.16 |
| 1981-05-09 | Joaquin Andujar | R | 28 | L 5-9 | @ CIN | 3 | 103 | L | 4.0 | 7 | 6 | 5 | 0 | 2 | 1 | 0 | 0 | 0 | -- | 1-2 | 4.09 | 1.59 |
| 1981-05-10 | Joe Niekro | R | 37 | W 7-5 | @ CIN | 7 | 284 | W | 5.0 | 7 | 2 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | -- | 3-3 | 2.50 | 1.09 |
| 1981-05-11 | Nolan Ryan | R | 34 | W 5-0 | @ CIN | 5 | 402 | W | 9.0 | 7 | 0 | 0 | 0 | 3 | 11 | 0 | 0 | 0 | -- | 2-1 | 1.29 | 1.17 |
| 1981-05-12 | Bob Knepper | L | 27 | W 2-3 | vs SLN | 6 | 139 | - | 9.0 | 6 | 2 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | -- | 3-0 | 1.00 | 0.87 |
| 1981-05-13 | Don Sutton | R | 36 | L 3-0 | vs SLN | 7 | 524 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 3-4 | 2.87 | 1.06 |
| 1981-05-14 | Bobby Sprowl | L | 25 | W 6-7 | vs SLN | 1 | 4 | - | 7.0 | 4 | 1 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | -- | 0-0 | 3.60 | 1.27 |
| 1981-05-15 | Joe Niekro | R | 37 | L 5-0 | vs CHN | 8 | 285 | W | 9.0 | 4 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 4-3 | 2.14 | 1.03 |
| 1981-05-16 | Nolan Ryan | R | 34 | L 6-1 | vs CHN | 6 | 403 | W | 7.0 | 6 | 1 | 0 | 0 | 3 | 8 | 0 | 0 | 0 | -- | 3-1 | 1.07 | 1.19 |
| 1981-05-17 | Bob Knepper | L | 27 | L 6-1 | vs CHN | 7 | 140 | W | 7.1 | 4 | 1 | 1 | 0 | 4 | 3 | 0 | 0 | 0 | -- | 4-0 | 1.02 | 0.89 |
| 1981-05-19 | Don Sutton | R | 36 | L 12-15 | @ SLN | 8 | 525 | - | 3.2 | 8 | 7 | 7 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 3-4 | 3.88 | 1.16 |
| 1981-05-20 | Joe Niekro | R | 37 | W 4-3 | @ SLN | 9 | 286 | W | 10.0 | 10 | 3 | 3 | 0 | 3 | 8 | 0 | 0 | 0 | -- | 5-3 | 2.22 | 1.07 |
| 1981-05-21 | Nolan Ryan | R | 34 | L 1-3 | @ SLN | 7 | 404 | L | 6.1 | 3 | 3 | 1 | 0 | 3 | 6 | 0 | 0 | 0 | -- | 3-2 | 1.13 | 1.17 |
| 1981-05-22 | Bob Knepper | L | 27 | W 3-6 | vs SFN | 8 | 141 | - | 8.2 | 11 | 2 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 4-0 | 1.18 | 0.97 |
| 1981-05-23 | Vern Ruhle | R | 30 | L 5-3 | vs SFN | 5 | 123 | - | 4.2 | 9 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | -- | 0-1 | 2.89 | 1.21 |
| 1981-05-24 | Don Sutton | R | 36 | W 1-2 | vs SFN | 9 | 526 | L | 8.0 | 7 | 2 | 2 | 0 | 2 | 8 | 0 | 0 | 0 | -- | 3-5 | 3.66 | 1.15 |
| 1981-05-25 | Joe Niekro | R | 37 | L 6-3 | vs SDN | 10 | 287 | W | 6.2 | 9 | 3 | 2 | 0 | 3 | 1 | 0 | 0 | 0 | -- | 6-3 | 2.25 | 1.13 |
| 1981-05-26 | Nolan Ryan | R | 34 | L 1-0 | vs SDN | 8 | 405 | W | 7.0 | 4 | 0 | 0 | 0 | 4 | 6 | 0 | 0 | 0 | -- | 4-2 | 0.98 | 1.16 |
| 1981-05-27 | Bob Knepper | L | 27 | L 1-0 | vs SDN | 9 | 142 | W | 9.0 | 6 | 0 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | -- | 5-0 | 1.03 | 0.94 |
| 1981-05-29 | Don Sutton | R | 36 | L 1-3 | @ SFN | 10 | 527 | L | 7.2 | 5 | 3 | 3 | 0 | 4 | 7 | 0 | 0 | 0 | -- | 3-6 | 3.63 | 1.15 |
| 1981-05-30 | Joe Niekro | R | 37 | W 9-8 | @ SFN | 11 | 288 | - | 8.1 | 7 | 5 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | -- | 6-3 | 2.05 | 1.11 |
| 1981-05-31 | Nolan Ryan | R | 34 | L 1-6 | @ SFN | 9 | 406 | L | 7.0 | 8 | 5 | 5 | 0 | 6 | 4 | 0 | 0 | 0 | -- | 4-3 | 1.60 | 1.26 |
| 1981-06-02 | Bob Knepper | L | 27 | W 2-1 | @ SDN | 10 | 143 | - | 7.0 | 6 | 1 | 1 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 5-0 | 1.05 | 0.97 |
| 1981-06-03 | Don Sutton | R | 36 | W 6-1 | @ SDN | 11 | 528 | W | 9.0 | 7 | 1 | 1 | 0 | 0 | 6 | 0 | 0 | 0 | -- | 4-6 | 3.32 | 1.11 |
| 1981-06-04 | Joe Niekro | R | 37 | L 5-7 | @ SDN | 12 | 289 | L | 3.1 | 8 | 6 | 6 | 1 | 3 | 0 | 0 | 0 | 0 | -- | 6-4 | 2.57 | 1.20 |
| 1981-06-05 | Nolan Ryan | R | 34 | L 3-0 | vs NYN | 10 | 407 | W | 9.0 | 5 | 0 | 0 | 0 | 2 | 10 | 0 | 0 | 0 | -- | 5-3 | 1.39 | 1.20 |
| 1981-06-06 | Vern Ruhle | R | 30 | L 6-2 | vs NYN | 6 | 124 | W | 5.0 | 6 | 2 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 1-1 | 2.83 | 1.29 |
| 1981-06-07 | Bob Knepper | L | 27 | W 1-3 | vs NYN | 11 | 144 | L | 9.0 | 6 | 3 | 2 | 1 | 3 | 5 | 0 | 0 | 0 | -- | 5-1 | 1.15 | 0.98 |
| 1981-06-08 | Don Sutton | R | 36 | L 3-4 | @ PHI | 12 | 529 | L | 6.0 | 7 | 4 | 3 | 0 | 1 | 3 | 0 | 0 | 0 | -- | 4-7 | 3.40 | 1.12 |
| 1981-06-09 | Joe Niekro | R | 37 | L 3-10 | @ PHI | 13 | 290 | L | 4.0 | 6 | 6 | 4 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 6-5 | 2.84 | 1.23 |
| 1981-06-10 | Nolan Ryan | R | 34 | L 4-5 | @ PHI | 11 | 408 | - | 7.2 | 2 | 1 | 1 | 0 | 3 | 8 | 0 | 0 | 0 | -- | 5-3 | 1.37 | 1.14 |
| 1981-08-10 | Don Sutton | R | 36 | W 6-5 | @ SFN | 13 | 530 | - | 6.0 | 7 | 3 | 3 | 1 | 1 | 4 | 0 | 0 | 0 | -- | 4-7 | 3.48 | 1.14 |
| 1981-08-11 | Joe Niekro | R | 37 | L 2-3 | @ SFN | 14 | 291 | L | 6.1 | 10 | 3 | 3 | 0 | 2 | 7 | 0 | 0 | 0 | -- | 6-6 | 2.91 | 1.26 |
| 1981-08-12 | Vern Ruhle | R | 31 | W 5-4 | @ SFN | 7 | 125 | - | 5.2 | 6 | 4 | 4 | 2 | 0 | 4 | 0 | 0 | 0 | -- | 1-1 | 3.29 | 1.24 |
| 1981-08-13 | Bob Knepper | L | 27 | L 1-9 | @ SDN | 12 | 145 | L | 4.0 | 5 | 4 | 4 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 5-2 | 1.50 | 1.01 |
| 1981-08-14 | Nolan Ryan | R | 35 | W 5-1 | @ SDN | 12 | 409 | W | 6.0 | 2 | 1 | 1 | 0 | 2 | 3 | 0 | 0 | 0 | -- | 6-3 | 1.38 | 1.11 |
| 1981-08-15 | Don Sutton | R | 36 | W 5-0 | @ SDN | 14 | 531 | W | 8.0 | 3 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | -- | 5-7 | 3.19 | 1.08 |
| 1981-08-16 | Joe Niekro | R | 37 | W 3-0 | @ SDN | 15 | 292 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 7-6 | 2.72 | 1.21 |
| 1981-08-17 | Vern Ruhle | R | 31 | W 2-6 | vs MON | 8 | 126 | L | 6.2 | 8 | 5 | 5 | 0 | 3 | 1 | 0 | 0 | 0 | -- | 1-2 | 3.75 | 1.29 |
| 1981-08-18 | Bob Knepper | L | 27 | L 4-2 | vs MON | 13 | 146 | W | 8.2 | 8 | 2 | 2 | 1 | 1 | 4 | 0 | 0 | 0 | -- | 6-2 | 1.55 | 1.01 |
| 1981-08-19 | Nolan Ryan | R | 35 | L 9-1 | vs MON | 13 | 410 | W | 6.0 | 2 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | -- | 7-3 | 1.29 | 1.05 |
| 1981-08-21 | Don Sutton | R | 36 | L 4-5 | @ PHI | 15 | 532 | - | 6.0 | 8 | 3 | 2 | 0 | 4 | 5 | 0 | 0 | 0 | -- | 5-7 | 3.18 | 1.14 |
| 1981-08-22 | Joe Niekro | R | 37 | L 4-8 | @ PHI | 16 | 293 | L | 4.0 | 7 | 5 | 5 | 2 | 1 | 0 | 0 | 0 | 0 | -- | 7-7 | 3.03 | 1.24 |
| 1981-08-23 | Bob Knepper | L | 27 | L 0-6 | @ PHI | 14 | 147 | L | 5.0 | 9 | 6 | 6 | 1 | 0 | 1 | 0 | 0 | 0 | -- | 6-3 | 1.99 | 1.05 |
| 1981-08-25 | Nolan Ryan | R | 35 | L 1-2 | @ NYN | 14 | 411 | - | 7.0 | 3 | 1 | 0 | 0 | 4 | 7 | 0 | 0 | 0 | -- | 7-3 | 1.19 | 1.05 |
| 1981-08-26 | Don Sutton | R | 36 | W 9-3 | @ NYN | 16 | 533 | W | 5.0 | 6 | 3 | 3 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 6-7 | 3.28 | 1.15 |
| 1981-08-27 | Joe Niekro | R | 37 | L 2-3 | @ NYN | 17 | 294 | - | 7.1 | 5 | 2 | 2 | 0 | 1 | 4 | 0 | 0 | 0 | -- | 7-7 | 3.00 | 1.22 |
| 1981-08-28 | Bob Knepper | L | 27 | L 3-2 | vs PHI | 15 | 148 | - | 7.0 | 5 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 6-3 | 1.95 | 1.04 |
| 1981-08-29 | Vern Ruhle | R | 31 | L 6-1 | vs PHI | 9 | 127 | W | 6.1 | 7 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | -- | 2-3 | 3.57 | 1.33 |
| 1981-08-29 | Billy Smith | R | 27 | L 2-1 | vs PHI | 1 | 1 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 1-0 | 2.81 | 0.88 |
| 1981-08-30 | Nolan Ryan | R | 35 | L 5-4 | vs PHI | 15 | 412 | - | 7.0 | 8 | 3 | 3 | 1 | 5 | 4 | 0 | 0 | 0 | -- | 7-3 | 1.37 | 1.10 |
| 1981-08-31 | Don Sutton | R | 36 | L 6-1 | vs NYN | 17 | 534 | W | 9.0 | 9 | 1 | 1 | 1 | 1 | 8 | 0 | 0 | 0 | -- | 7-7 | 3.10 | 1.15 |
| 1981-09-01 | Joe Niekro | R | 37 | L 3-2 | vs NYN | 18 | 295 | - | 6.1 | 3 | 2 | 2 | 0 | 2 | 5 | 0 | 0 | 0 | -- | 7-7 | 3.00 | 1.20 |
| 1981-09-02 | Bob Knepper | L | 27 | L 8-0 | vs NYN | 16 | 149 | W | 9.0 | 3 | 0 | 0 | 0 | 1 | 9 | 0 | 0 | 0 | -- | 7-3 | 1.80 | 0.99 |
| 1981-09-03 | Vern Ruhle | R | 31 | W 2-1 | @ MON | 10 | 128 | W | 6.0 | 4 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | -- | 3-3 | 3.38 | 1.30 |
| 1981-09-04 | Nolan Ryan | R | 35 | W 5-0 | @ MON | 16 | 413 | W | 7.0 | 2 | 0 | 0 | 0 | 3 | 7 | 0 | 0 | 0 | -- | 8-3 | 1.29 | 1.08 |
| 1981-09-05 | Don Sutton | R | 36 | L 2-5 | @ MON | 18 | 535 | L | 7.0 | 9 | 5 | 4 | 2 | 1 | 3 | 0 | 0 | 0 | -- | 7-8 | 3.22 | 1.16 |
| 1981-09-06 | Joe Niekro | R | 37 | W 4-3 | @ MON | 19 | 296 | - | 6.0 | 7 | 2 | 2 | 1 | 3 | 1 | 0 | 0 | 0 | -- | 7-7 | 3.00 | 1.22 |
| 1981-09-07 | Bob Knepper | L | 27 | W 3-2 | @ ATL | 17 | 150 | - | 7.0 | 4 | 2 | 2 | 1 | 3 | 0 | 0 | 0 | 0 | -- | 7-3 | 1.84 | 0.99 |
| 1981-09-08 | Vern Ruhle | R | 31 | L 2-3 | @ ATL | 11 | 129 | - | 7.0 | 3 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | -- | 3-3 | 3.04 | 1.23 |
| 1981-09-09 | Nolan Ryan | R | 35 | L 0-9 | @ ATL | 17 | 414 | L | 4.0 | 7 | 5 | 5 | 1 | 5 | 3 | 0 | 0 | 0 | -- | 8-4 | 1.63 | 1.15 |
| 1981-09-11 | Don Sutton | R | 36 | L 6-0 | vs SFN | 19 | 536 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | -- | 8-8 | 3.00 | 1.13 |
| 1981-09-12 | Joe Niekro | R | 37 | L 5-2 | vs SFN | 20 | 297 | W | 6.2 | 4 | 1 | 1 | 1 | 5 | 4 | 0 | 0 | 0 | -- | 8-7 | 2.91 | 1.22 |
| 1981-09-13 | Bob Knepper | L | 27 | L 3-0 | vs SFN | 18 | 151 | W | 7.0 | 6 | 0 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | -- | 8-3 | 1.75 | 1.01 |
| 1981-09-14 | Vern Ruhle | R | 31 | W 2-4 | vs CIN | 12 | 130 | L | 7.1 | 11 | 4 | 3 | 0 | 0 | 6 | 0 | 0 | 0 | -- | 3-4 | 3.12 | 1.26 |
| 1981-09-15 | Nolan Ryan | R | 35 | W 0-4 | vs CIN | 18 | 415 | L | 6.0 | 6 | 4 | 3 | 0 | 4 | 4 | 0 | 0 | 0 | -- | 8-5 | 1.77 | 1.17 |
| 1981-09-16 | Don Sutton | R | 36 | W 5-2 | @ SDN | 20 | 537 | W | 7.0 | 4 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | -- | 9-8 | 2.85 | 1.10 |
| 1981-09-17 | Joe Niekro | R | 37 | W 9-0 | @ SDN | 21 | 298 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | -- | 9-7 | 2.74 | 1.18 |
| 1981-09-18 | Bob Knepper | L | 27 | L 2-5 | @ SFN | 19 | 152 | L | 4.0 | 8 | 4 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | -- | 8-4 | 1.96 | 1.05 |
| 1981-09-19 | Vern Ruhle | R | 31 | W 8-1 | @ SFN | 13 | 131 | W | 9.0 | 4 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | -- | 4-4 | 2.90 | 1.18 |
| 1981-09-20 | Nolan Ryan | R | 35 | W 7-3 | @ SFN | 19 | 416 | W | 9.0 | 7 | 3 | 3 | 0 | 4 | 8 | 0 | 0 | 0 | -- | 9-5 | 1.85 | 1.18 |
| 1981-09-22 | Don Sutton | R | 36 | L 3-0 | vs ATL | 21 | 538 | W | 9.0 | 3 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | -- | 10-8 | 2.68 | 1.05 |
| 1981-09-23 | Joe Niekro | R | 37 | W 1-3 | vs ATL | 22 | 299 | L | 6.0 | 6 | 3 | 3 | 0 | 3 | 3 | 0 | 0 | 0 | -- | 9-8 | 2.81 | 1.19 |
| 1981-09-24 | Bob Knepper | L | 27 | L 5-3 | vs ATL | 20 | 153 | W | 7.2 | 5 | 3 | 3 | 0 | 4 | 4 | 0 | 0 | 0 | -- | 9-4 | 2.03 | 1.05 |
| 1981-09-25 | Vern Ruhle | R | 31 | W 0-3 | vs LAN | 14 | 132 | L | 7.0 | 9 | 3 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | -- | 4-5 | 2.87 | 1.19 |
| 1981-09-26 | Nolan Ryan | R | 35 | L 5-0 | vs LAN | 20 | 417 | W | 9.0 | 0 | 0 | 0 | 0 | 3 | 11 | 0 | 0 | 0 | -- | 10-5 | 1.74 | 1.12 |
| 1981-09-27 | Don Sutton | R | 36 | L 4-1 | vs LAN | 22 | 539 | W | 9.0 | 2 | 1 | 1 | 1 | 1 | 9 | 0 | 0 | 0 | -- | 11-8 | 2.58 | 1.01 |
| 1981-09-28 | Joe Niekro | R | 37 | L 2-1 | vs SDN | 23 | 300 | - | 8.0 | 5 | 1 | 1 | 1 | 2 | 3 | 0 | 0 | 0 | -- | 9-8 | 2.72 | 1.18 |
| 1981-09-29 | Bob Knepper | L | 27 | W 1-2 | vs SDN | 21 | 154 | L | 7.0 | 5 | 2 | 2 | 0 | 2 | 6 | 0 | 0 | 0 | -- | 9-5 | 2.06 | 1.05 |
| 1981-09-30 | Vern Ruhle | R | 31 | L 2-5 | @ CIN | 15 | 133 | L | 5.2 | 5 | 3 | 3 | 1 | 0 | 2 | 0 | 0 | 0 | -- | 4-6 | 2.97 | 1.17 |
| 1981-10-01 | Nolan Ryan | R | 35 | W 8-1 | @ CIN | 21 | 418 | W | 9.0 | 7 | 1 | 1 | 0 | 3 | 9 | 0 | 0 | 0 | -- | 11-5 | 1.69 | 1.12 |
| 1981-10-02 | Don Sutton | R | 37 | L 1-6 | @ LAN | 23 | 540 | L | 2.0 | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | -- | 11-9 | 2.60 | 1.01 |
| 1981-10-03 | Joe Niekro | R | 37 | L 2-7 | @ LAN | 24 | 301 | L | 4.0 | 4 | 3 | 3 | 0 | 2 | 1 | 0 | 0 | 0 | -- | 9-9 | 2.82 | 1.19 |
| 1981-10-04 | Bob Knepper | L | 27 | W 5-3 | @ LAN | 22 | 155 | - | 4.0 | 4 | 3 | 3 | 1 | 1 | 3 | 0 | 0 | 0 | -- | 9-5 | 2.18 | 1.06 |
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