| 1980-04-10 | vs MIN | 1 | L 7-9 | 0-1 | 6 | 24,415 | Rick Langford | Jerry Koosman | Doug Corbett | Steve McCatty | | 7 | 9 | -2 |
| 1980-04-11 | vs MIN | 2 | W 1-0 | 1-1 | 6 | 5,729 | Matt Keough | Pete Redfern | Matt Keough | Pete Redfern | | 8 | 9 | -1 |
| 1980-04-12 | vs MIN | 3 | L 0-6 | 1-2 | 7 | 5,783 | Brian Kingman | Geoff Zahn | Geoff Zahn | Brian Kingman | | 8 | 15 | -7 |
| 1980-04-13 | vs MIN | 4 | W 4-1 | 2-2 | 6 | 6,300 | Mike Norris | Roger Erickson | Mike Norris | Roger Erickson | | 12 | 16 | -4 |
| 1980-04-14 | vs SEA | 5 | L 1-7 | 2-3 | 7 | 5,260 | Steve McCatty | Glenn Abbott | Glenn Abbott | Steve McCatty | | 13 | 23 | -10 |
| 1980-04-15 | vs SEA | 6 | W 12-3 | 3-3 | 7 | 2,140 | Steve McCatty | Mike Parrott | Steve McCatty | Mike Parrott | | 25 | 26 | -1 |
| 1980-04-16 | vs SEA | 7 | W 6-1 | 4-3 | 4 | 2,418 | Matt Keough | Jim Beattie | Matt Keough | Jim Beattie | | 31 | 27 | 4 |
| 1980-04-18 | vs CAL | 8 | W 6-3 | 5-3 | 4 | 6,570 | Brian Kingman | Bruce Kison | Brian Kingman | Bruce Kison | | 37 | 30 | 7 |
| 1980-04-19 | vs CAL | 9 | W 3-1 | 6-3 | 3 | 5,239 | Mike Norris | Don Aase | Mike Norris | Don Aase | Jeff Jones | 40 | 31 | 9 |
| 1980-04-20 | vs CAL | 10 | W 6-1 | 8-3 | 1 | 0 | Matt Keough | Chris Knapp | Matt Keough | Chris Knapp | | 46 | 32 | 14 |
| 1980-04-20 | vs CAL | 11 | W 8-2 | 8-3 | 1 | 9,014 | Steve McCatty | Frank Tanana | Steve McCatty | Frank Tanana | | 54 | 34 | 20 |
| 1980-04-21 | @ SEA | 12 | W 4-2 | 9-3 | 1 | 4,466 | Dave Hamilton | Jim Beattie | Jeff Jones | Shane Rawley | | 58 | 36 | 22 |
| 1980-04-22 | @ SEA | 13 | L 4-5 | 9-4 | 1 | 4,059 | Brian Kingman | Rick Honeycutt | Rick Honeycutt | Brian Kingman | Byron McLaughlin | 62 | 41 | 21 |
| 1980-04-23 | @ SEA | 14 | W 5-2 | 10-4 | 1 | 4,075 | Mike Norris | Floyd Bannister | Rick Langford | Byron McLaughlin | | 67 | 43 | 24 |
| 1980-04-25 | @ MIN | 15 | L 3-10 | 10-5 | 2 | 2,664 | Matt Keough | Jerry Koosman | Jerry Koosman | Matt Keough | | 70 | 53 | 17 |
| 1980-04-26 | @ MIN | 16 | L 1-5 | 10-6 | 2 | 6,325 | Steve McCatty | Pete Redfern | Pete Redfern | Steve McCatty | | 71 | 58 | 13 |
| 1980-04-27 | @ MIN | 17 | L 11-20 | 10-7 | 2 | 19,859 | Brian Kingman | Geoff Zahn | Doug Corbett | Brian Kingman | | 82 | 78 | 4 |
| 1980-04-28 | @ CAL | 18 | W 8-0 | 11-7 | 2 | 30,889 | Rick Langford | Bruce Kison | Rick Langford | Bruce Kison | | 90 | 78 | 12 |
| 1980-04-29 | @ CAL | 19 | W 4-2 | 12-7 | 2 | 32,334 | Mike Norris | Frank Tanana | Mike Norris | Frank Tanana | | 94 | 80 | 14 |
| 1980-04-30 | @ CAL | 20 | L 1-2 | 12-8 | 2 | 22,551 | Matt Keough | Don Aase | Don Aase | Matt Keough | | 95 | 82 | 13 |
| 1980-05-02 | vs DET | 21 | W 10-6 | 13-8 | 1 | 8,636 | Steve McCatty | Dave Rozema | Steve McCatty | Dave Rozema | | 105 | 88 | 17 |
| 1980-05-03 | vs DET | 22 | W 5-3 | 14-8 | 1 | 7,062 | Brian Kingman | Jack Morris | Brian Kingman | Jack Morris | Jeff Jones | 110 | 91 | 19 |
| 1980-05-04 | vs DET | 23 | L 0-4 | 15-9 | 1 | 0 | Rick Langford | Milt Wilcox | Milt Wilcox | Rick Langford | | 110 | 95 | 15 |
| 1980-05-04 | vs DET | 24 | W 1-0 | 15-9 | 1 | 18,217 | Mike Norris | Dan Schatzeder | Mike Norris | Dan Schatzeder | | 111 | 95 | 16 |
| 1980-05-05 | vs CLE | 25 | W 5-1 | 16-9 | 1 | 12,605 | Matt Keough | John Denny | Matt Keough | John Denny | | 116 | 96 | 20 |
| 1980-05-06 | vs CLE | 26 | L 3-4 | 16-10 | 1 | 24,309 | Steve McCatty | Len Barker | Len Barker | Steve McCatty | | 119 | 100 | 19 |
| 1980-05-07 | vs CLE | 27 | L 1-2 | 16-11 | 1 | 4,731 | Brian Kingman | Rick Waits | Rick Waits | Brian Kingman | | 120 | 102 | 18 |
| 1980-05-10 | vs TOR | 28 | W 4-3 | 17-11 | 1 | 4,925 | Rick Langford | Jim Clancy | Rick Langford | Jerry Garvin | | 124 | 105 | 19 |
| 1980-05-11 | vs TOR | 29 | W 12-1 | 18-11 | 1 | 7,843 | Mike Norris | Dave Lemanczyk | Mike Norris | Dave Lemanczyk | | 136 | 106 | 30 |
| 1980-05-13 | @ DET | 30 | L 3-4 | 18-12 | 1 | 13,332 | Matt Keough | Jack Morris | Jack Morris | Matt Keough | Aurelio Lopez | 139 | 110 | 29 |
| 1980-05-14 | @ DET | 31 | L 5-6 | 18-13 | 1 | 16,694 | Rick Langford | Milt Wilcox | Aurelio Lopez | Jeff Jones | | 144 | 116 | 28 |
| 1980-05-16 | @ TOR | 32 | L 0-1 | 18-14 | 1 | 16,138 | Mike Norris | Jesse Jefferson | Jesse Jefferson | Mike Norris | | 144 | 117 | 27 |
| 1980-05-17 | @ TOR | 33 | W 4-2 | 19-14 | 1 | 23,074 | Matt Keough | Dave Stieb | Matt Keough | Joey McLaughlin | | 148 | 119 | 29 |
| 1980-05-18 | @ TOR | 34 | L 1-12 | 19-15 | 2 | 14,414 | Rick Langford | Paul Mirabella | Paul Mirabella | Rick Langford | | 149 | 131 | 18 |
| 1980-05-19 | @ KCA | 35 | L 5-6 | 19-16 | 3 | 28,889 | Steve McCatty | Dennis Leonard | Dan Quisenberry | Dave Hamilton | | 154 | 137 | 17 |
| 1980-05-20 | @ KCA | 36 | L 0-1 | 19-17 | 3 | 23,698 | Mike Norris | Rich Gale | Rich Gale | Mike Norris | Dan Quisenberry | 154 | 138 | 16 |
| 1980-05-21 | @ KCA | 37 | W 4-2 | 20-17 | 3 | 24,030 | Brian Kingman | Larry Gura | Bob Lacey | Dan Quisenberry | | 158 | 140 | 18 |
| 1980-05-22 | @ KCA | 38 | L 3-16 | 20-18 | 3 | 23,124 | Matt Keough | Renie Martin | Renie Martin | Matt Keough | | 161 | 156 | 5 |
| 1980-05-23 | vs TEX | 39 | L 1-3 | 20-19 | 4 | 4,141 | Rick Langford | Fergie Jenkins | Fergie Jenkins | Rick Langford | | 162 | 159 | 3 |
| 1980-05-24 | vs TEX | 40 | W 15-7 | 21-19 | 3 | 5,061 | Steve McCatty | Gaylord Perry | Steve McCatty | Gaylord Perry | | 177 | 166 | 11 |
| 1980-05-25 | vs TEX | 41 | L 3-7 | 21-20 | 5 | 10,549 | Mike Norris | Doc Medich | Doc Medich | Mike Norris | Jim Kern | 180 | 173 | 7 |
| 1980-05-26 | vs KCA | 42 | W 4-1 | 22-20 | 4 | 21,882 | Matt Keough | Renie Martin | Matt Keough | Renie Martin | | 184 | 174 | 10 |
| 1980-05-27 | vs KCA | 43 | L 2-4 | 22-21 | 4 | 4,488 | Brian Kingman | Dennis Leonard | Dennis Leonard | Brian Kingman | | 186 | 178 | 8 |
| 1980-05-28 | vs KCA | 44 | W 6-3 | 23-21 | 3 | 4,094 | Rick Langford | Rich Gale | Rick Langford | Rich Gale | | 192 | 181 | 11 |
| 1980-05-30 | @ TEX | 45 | W 6-3 | 24-21 | 2 | 26,613 | Steve McCatty | Gaylord Perry | Steve McCatty | Gaylord Perry | | 198 | 184 | 14 |
| 1980-05-31 | @ TEX | 46 | W 4-3 | 25-21 | 2 | 24,305 | Mike Norris | Doc Medich | Mike Norris | Doc Medich | Bob Lacey | 202 | 187 | 15 |
| 1980-06-01 | @ TEX | 47 | L 3-7 | 25-22 | 2 | 17,892 | Matt Keough | Danny Darwin | Danny Darwin | Matt Keough | | 205 | 194 | 11 |
| 1980-06-02 | @ CLE | 48 | L 5-10 | 25-23 | 3 | 4,445 | Brian Kingman | Wayne Garland | Wayne Garland | Brian Kingman | | 210 | 204 | 6 |
| 1980-06-03 | @ CLE | 49 | L 4-6 | 25-24 | 3 | 4,597 | Rick Langford | Len Barker | Victor Cruz | Rick Langford | | 214 | 210 | 4 |
| 1980-06-04 | @ CLE | 50 | L 3-5 | 25-25 | 3 | 8,608 | Steve McCatty | Dan Spillner | Dan Spillner | Steve McCatty | Victor Cruz | 217 | 215 | 2 |
| 1980-06-06 | vs BOS | 51 | L 8-14 | 25-26 | 3 | 15,947 | Mike Norris | Chuck Rainey | Chuck Rainey | Mike Norris | | 225 | 229 | -4 |
| 1980-06-07 | vs BOS | 52 | W 4-1 | 26-26 | 3 | 13,005 | Matt Keough | Mike Torrez | Matt Keough | Mike Torrez | | 229 | 230 | -1 |
| 1980-06-08 | vs BOS | 53 | L 1-6 | 26-27 | 3 | 18,738 | Brian Kingman | Dennis Eckersley | Tom Burgmeier | Dave Hamilton | | 230 | 236 | -6 |
| 1980-06-09 | vs BAL | 54 | L 2-3 | 26-28 | 3 | 20,162 | Rick Langford | Mike Flanagan | Mike Flanagan | Rick Langford | | 232 | 239 | -7 |
| 1980-06-10 | vs BAL | 55 | W 7-4 | 27-28 | 3 | 3,873 | Steve McCatty | Scott McGregor | Steve McCatty | Scott McGregor | | 239 | 243 | -4 |
| 1980-06-11 | vs BAL | 56 | W 6-2 | 28-28 | 3 | 5,635 | Mike Norris | Jim Palmer | Mike Norris | Sammy Stewart | | 245 | 245 | 0 |
| 1980-06-13 | vs NYA | 57 | W 4-3 | 29-29 | 3 | 0 | Brian Kingman | Ron Guidry | Brian Kingman | Ron Guidry | | 249 | 248 | 1 |
| 1980-06-13 | vs NYA | 58 | L 4-6 | 29-29 | 3 | 47,768 | Matt Keough | Tom Underwood | Ron Davis | Matt Keough | Rich Gossage | 253 | 254 | -1 |
| 1980-06-14 | vs NYA | 59 | L 1-2 | 29-30 | 3 | 26,410 | Rick Langford | Ed Figueroa | Ed Figueroa | Rick Langford | Rich Gossage | 254 | 256 | -2 |
| 1980-06-15 | vs NYA | 60 | L 2-8 | 29-31 | 3 | 47,186 | Steve McCatty | Luis Tiant | Luis Tiant | Steve McCatty | | 256 | 264 | -8 |
| 1980-06-16 | @ BOS | 61 | W 11-8 | 30-31 | 3 | 25,026 | Mike Norris | Chuck Rainey | Mike Norris | Chuck Rainey | | 267 | 272 | -5 |
| 1980-06-17 | @ BOS | 62 | L 2-6 | 30-32 | 3 | 24,722 | Matt Keough | Mike Torrez | Mike Torrez | Matt Keough | | 269 | 278 | -9 |
| 1980-06-18 | @ BAL | 63 | L 2-3 | 30-33 | 3 | 17,436 | Brian Kingman | Mike Flanagan | Mike Flanagan | Jeff Jones | | 271 | 281 | -10 |
| 1980-06-19 | @ BAL | 64 | L 3-4 | 30-34 | 3 | 15,491 | Rick Langford | Scott McGregor | Scott McGregor | Rick Langford | | 274 | 285 | -11 |
| 1980-06-20 | @ NYA | 65 | L 7-15 | 30-35 | 3 | 45,935 | Steve McCatty | Luis Tiant | Luis Tiant | Steve McCatty | Ron Davis | 281 | 300 | -19 |
| 1980-06-21 | @ NYA | 66 | L 3-5 | 30-36 | 3 | 51,598 | Mike Norris | Tommy John | Tommy John | Mike Norris | Rich Gossage | 284 | 305 | -21 |
| 1980-06-22 | @ NYA | 67 | W 5-2 | 31-36 | 3 | 45,745 | Matt Keough | Tom Underwood | Matt Keough | Tom Underwood | | 289 | 307 | -18 |
| 1980-06-23 | vs MIL | 68 | L 0-8 | 31-37 | 3 | 17,666 | Brian Kingman | Reggie Cleveland | Reggie Cleveland | Brian Kingman | | 289 | 315 | -26 |
| 1980-06-24 | vs MIL | 69 | L 3-5 | 31-38 | 4 | 4,899 | Rick Langford | Bill Travers | Bill Travers | Rick Langford | Bob McClure | 292 | 320 | -28 |
| 1980-06-25 | vs MIL | 70 | L 2-5 | 31-39 | 4 | 6,856 | Steve McCatty | Moose Haas | Moose Haas | Steve McCatty | | 294 | 325 | -31 |
| 1980-06-27 | vs CHA | 71 | W 3-1 | 32-39 | 4 | 8,482 | Mike Norris | Ross Baumgarten | Mike Norris | Ross Baumgarten | | 297 | 326 | -29 |
| 1980-06-28 | vs CHA | 72 | L 0-3 | 32-40 | 4 | 5,204 | Matt Keough | Rich Wortham | Rich Wortham | Matt Keough | Ed Farmer | 297 | 329 | -32 |
| 1980-06-29 | vs CHA | 73 | L 0-3 | 32-41 | 4 | 7,369 | Brian Kingman | Britt Burns | Britt Burns | Brian Kingman | Mike Proly | 297 | 332 | -35 |
| 1980-06-30 | @ MIL | 74 | L 2-5 | 32-42 | 4 | 19,725 | Rick Langford | Bill Travers | Bill Travers | Rick Langford | | 299 | 337 | -38 |
| 1980-07-01 | @ MIL | 75 | L 2-5 | 32-43 | 6 | 20,769 | Steve McCatty | Moose Haas | Moose Haas | Steve McCatty | | 301 | 342 | -41 |
| 1980-07-02 | @ MIL | 76 | W 5-3 | 33-43 | 4 | 18,494 | Mike Norris | Lary Sorensen | Mike Norris | Bob McClure | | 306 | 345 | -39 |
| 1980-07-03 | @ MIL | 77 | W 7-5 | 34-43 | 4 | 15,298 | Matt Keough | Mike Caldwell | Matt Keough | Mike Caldwell | Bob Lacey | 313 | 350 | -37 |
| 1980-07-04 | @ CHA | 78 | W 2-0 | 35-43 | 4 | 11,428 | Brian Kingman | Britt Burns | Brian Kingman | Britt Burns | | 315 | 350 | -35 |
| 1980-07-05 | @ CHA | 79 | W 5-0 | 36-43 | 4 | 20,559 | Rick Langford | Richard Dotson | Rick Langford | Richard Dotson | | 320 | 350 | -30 |
| 1980-07-06 | @ CHA | 80 | L 0-2 | 36-45 | 4 | 0 | Mike Norris | Steve Trout | Steve Trout | Mike Norris | | 320 | 352 | -32 |
| 1980-07-06 | @ CHA | 81 | L 4-5 | 36-45 | 4 | 16,436 | Steve McCatty | Ken Kravec | Ed Farmer | Bob Lacey | | 324 | 357 | -33 |
| 1980-07-10 | vs CAL | 82 | L 1-5 | 37-46 | 5 | 0 | Matt Keough | Frank Tanana | Frank Tanana | Matt Keough | | 325 | 362 | -37 |
| 1980-07-10 | vs CAL | 83 | W 5-4 | 37-46 | 5 | 11,337 | Rick Langford | Don Aase | Rick Langford | Don Aase | | 330 | 366 | -36 |
| 1980-07-11 | vs CAL | 84 | W 6-2 | 38-46 | 5 | 7,696 | Brian Kingman | Chris Knapp | Brian Kingman | Chris Knapp | Jeff Jones | 336 | 368 | -32 |
| 1980-07-12 | @ CAL | 85 | W 5-4 | 39-46 | 4 | 32,186 | Mike Norris | Dave Lemanczyk | Mike Norris | Dave Lemanczyk | Craig Minetto | 341 | 372 | -31 |
| 1980-07-13 | @ CAL | 86 | L 4-5 | 39-47 | 5 | 24,393 | Steve McCatty | Ed Halicki | John Montague | Dave Hamilton | | 345 | 377 | -32 |
| 1980-07-14 | @ CAL | 87 | W 6-4 | 40-47 | 5 | 31,375 | Rick Langford | Bruce Kison | Rick Langford | Bruce Kison | | 351 | 381 | -30 |
| 1980-07-16 | vs DET | 88 | L 2-7 | 40-48 | 5 | 7,413 | Brian Kingman | Milt Wilcox | Roger Weaver | Brian Kingman | | 353 | 388 | -35 |
| 1980-07-17 | vs DET | 89 | W 5-2 | 41-48 | 4 | 6,370 | Matt Keough | Jack Morris | Matt Keough | Jack Morris | | 358 | 390 | -32 |
| 1980-07-18 | vs CLE | 90 | W 9-1 | 42-48 | 3 | 5,912 | Mike Norris | Dan Spillner | Mike Norris | Dan Spillner | | 367 | 391 | -24 |
| 1980-07-19 | vs CLE | 91 | W 3-0 | 43-48 | 3 | 6,506 | Steve McCatty | Rick Waits | Steve McCatty | Rick Waits | | 370 | 391 | -21 |
| 1980-07-20 | vs CLE | 92 | W 6-5 | 44-48 | 3 | 10,606 | Rick Langford | Ross Grimsley | Rick Langford | Victor Cruz | | 376 | 396 | -20 |
| 1980-07-21 | vs TOR | 93 | L 0-1 | 44-49 | 3 | 14,588 | Brian Kingman | Dave Stieb | Dave Stieb | Brian Kingman | | 376 | 397 | -21 |
| 1980-07-22 | vs TOR | 94 | L 2-6 | 45-50 | 3 | 0 | Matt Keough | Jesse Jefferson | Jesse Jefferson | Matt Keough | Jerry Garvin | 378 | 403 | -25 |
| 1980-07-22 | vs TOR | 95 | W 5-1 | 45-50 | 3 | 8,645 | Mike Norris | Paul Mirabella | Mike Norris | Paul Mirabella | | 383 | 404 | -21 |
| 1980-07-23 | vs TOR | 96 | W 6-2 | 46-50 | 3 | 4,765 | Steve McCatty | Jack Kucek | Steve McCatty | Jack Kucek | | 389 | 406 | -17 |
| 1980-07-25 | @ DET | 97 | W 5-3 | 47-50 | 3 | 41,229 | Rick Langford | Bruce Robbins | Rick Langford | Bruce Robbins | | 394 | 409 | -15 |
| 1980-07-26 | @ DET | 98 | L 0-7 | 47-51 | 3 | 39,758 | Brian Kingman | Dan Schatzeder | Dan Schatzeder | Brian Kingman | | 394 | 416 | -22 |
| 1980-07-27 | @ DET | 99 | L 2-4 | 48-52 | 3 | 0 | Craig Minetto | Milt Wilcox | Milt Wilcox | Craig Minetto | | 396 | 420 | -24 |
| 1980-07-27 | @ DET | 100 | W 4-0 | 48-52 | 3 | 44,093 | Matt Keough | Jack Morris | Matt Keough | Jack Morris | Bob Lacey | 400 | 420 | -20 |
| 1980-07-28 | @ TOR | 101 | W 5-3 | 49-52 | 2 | 14,457 | Mike Norris | Paul Mirabella | Mike Norris | Mike Barlow | | 405 | 423 | -18 |
| 1980-07-29 | @ TOR | 102 | W 6-5 | 50-52 | 2 | 16,704 | Steve McCatty | Jim Clancy | Bob Lacey | Jerry Garvin | | 411 | 428 | -17 |
| 1980-07-30 | @ TOR | 103 | W 11-1 | 51-52 | 2 | 17,654 | Rick Langford | Dave Stieb | Rick Langford | Dave Stieb | | 422 | 429 | -7 |
| 1980-08-01 | @ CLE | 104 | W 2-1 | 52-52 | 2 | 16,439 | Brian Kingman | Rick Waits | Brian Kingman | Rick Waits | Dave Beard | 424 | 430 | -6 |
| 1980-08-03 | @ CLE | 105 | W 11-3 | 53-53 | 2 | 0 | Matt Keough | Wayne Garland | Matt Keough | Wayne Garland | Jeff Jones | 435 | 433 | 2 |
| 1980-08-03 | @ CLE | 106 | L 2-4 | 53-53 | 2 | 17,587 | Mike Norris | Len Barker | Len Barker | Mike Norris | | 437 | 437 | 0 |
| 1980-08-04 | vs MIN | 107 | W 11-2 | 54-53 | 2 | 16,741 | Steve McCatty | Geoff Zahn | Steve McCatty | Geoff Zahn | | 448 | 439 | 9 |
| 1980-08-05 | vs MIN | 108 | W 3-2 | 55-53 | 2 | 4,651 | Rick Langford | Jerry Koosman | Rick Langford | Jerry Koosman | | 451 | 441 | 10 |
| 1980-08-06 | vs MIN | 109 | W 3-1 | 56-53 | 2 | 6,697 | Brian Kingman | Roger Erickson | Brian Kingman | Roger Erickson | | 454 | 442 | 12 |
| 1980-08-08 | vs SEA | 110 | L 1-2 | 56-54 | 2 | 6,283 | Matt Keough | Jim Beattie | Shane Rawley | Matt Keough | Dave Roberts | 455 | 444 | 11 |
| 1980-08-09 | vs SEA | 111 | W 2-1 | 57-54 | 2 | 13,629 | Mike Norris | Rick Honeycutt | Mike Norris | Rick Honeycutt | | 457 | 445 | 12 |
| 1980-08-10 | vs SEA | 112 | L 1-2 | 58-55 | 2 | 0 | Steve McCatty | Glenn Abbott | Dave Heaverlo | Steve McCatty | Shane Rawley | 458 | 447 | 11 |
| 1980-08-10 | vs SEA | 113 | W 6-1 | 58-55 | 2 | 13,062 | Rick Langford | Byron McLaughlin | Rick Langford | Byron McLaughlin | | 464 | 448 | 16 |
| 1980-08-12 | @ MIN | 114 | L 2-3 | 58-56 | 2 | 13,181 | Brian Kingman | Roger Erickson | Doug Corbett | Brian Kingman | | 466 | 451 | 15 |
| 1980-08-13 | @ MIN | 115 | W 6-2 | 59-56 | 2 | 11,615 | Matt Keough | Fernando Arroyo | Matt Keough | Fernando Arroyo | | 472 | 453 | 19 |
| 1980-08-14 | @ MIN | 116 | W 2-1 | 60-56 | 2 | 13,077 | Mike Norris | Darrell Jackson | Mike Norris | Doug Corbett | | 474 | 454 | 20 |
| 1980-08-15 | @ SEA | 117 | W 11-3 | 61-56 | 2 | 6,238 | Rick Langford | Glenn Abbott | Rick Langford | Glenn Abbott | | 485 | 457 | 28 |
| 1980-08-16 | @ SEA | 118 | W 8-3 | 62-56 | 2 | 17,111 | Steve McCatty | Byron McLaughlin | Steve McCatty | Byron McLaughlin | | 493 | 460 | 33 |
| 1980-08-17 | @ SEA | 119 | L 3-4 | 62-57 | 2 | 5,484 | Brian Kingman | Rob Dressler | Rob Dressler | Brian Kingman | Shane Rawley | 496 | 464 | 32 |
| 1980-08-19 | vs BOS | 120 | L 5-7 | 62-58 | 2 | 11,934 | Matt Keough | Mike Torrez | Bob Stanley | Craig Minetto | Tom Burgmeier | 501 | 471 | 30 |
| 1980-08-20 | vs BOS | 121 | W 2-1 | 63-58 | 2 | 7,569 | Mike Norris | Dennis Eckersley | Mike Norris | Dennis Eckersley | Bob Lacey | 503 | 472 | 31 |
| 1980-08-21 | vs BOS | 122 | L 1-5 | 63-59 | 2 | 11,357 | Rick Langford | John Tudor | John Tudor | Rick Langford | | 504 | 477 | 27 |
| 1980-08-22 | vs BAL | 123 | L 2-3 | 63-60 | 2 | 11,115 | Steve McCatty | Jim Palmer | Sammy Stewart | Steve McCatty | | 506 | 480 | 26 |
| 1980-08-23 | vs BAL | 124 | L 2-4 | 63-61 | 2 | 10,578 | Brian Kingman | Steve Stone | Steve Stone | Brian Kingman | Tim Stoddard | 508 | 484 | 24 |
| 1980-08-24 | vs BAL | 125 | L 0-3 | 63-62 | 2 | 18,160 | Matt Keough | Mike Flanagan | Mike Flanagan | Matt Keough | | 508 | 487 | 21 |
| 1980-08-25 | vs NYA | 126 | W 9-1 | 64-62 | 2 | 49,300 | Mike Norris | Tommy John | Mike Norris | Tommy John | | 517 | 488 | 29 |
| 1980-08-26 | vs NYA | 127 | W 3-1 | 65-62 | 2 | 32,146 | Rick Langford | Luis Tiant | Rick Langford | Luis Tiant | | 520 | 489 | 31 |
| 1980-08-28 | @ BOS | 128 | L 2-3 | 65-63 | 2 | 28,262 | Steve McCatty | Steve Renko | Tom Burgmeier | Steve McCatty | Bob Stanley | 522 | 492 | 30 |
| 1980-08-29 | @ BOS | 129 | L 3-6 | 65-64 | 2 | 28,666 | Brian Kingman | Mike Torrez | Mike Torrez | Brian Kingman | Tom Burgmeier | 525 | 498 | 27 |
| 1980-08-30 | @ BOS | 130 | L 6-7 | 65-65 | 2 | 27,146 | Matt Keough | Dennis Eckersley | Bill Campbell | Bob Lacey | | 531 | 505 | 26 |
| 1980-08-31 | @ BOS | 131 | L 1-5 | 65-66 | 2 | 32,022 | Mike Norris | John Tudor | John Tudor | Mike Norris | Bob Stanley | 532 | 510 | 22 |
| 1980-09-01 | @ NYA | 132 | L 0-5 | 65-67 | 2 | 31,103 | Rick Langford | Tom Underwood | Tom Underwood | Rick Langford | | 532 | 515 | 17 |
| 1980-09-02 | @ NYA | 133 | L 1-6 | 65-68 | 3 | 23,516 | Steve McCatty | Rudy May | Rudy May | Steve McCatty | | 533 | 521 | 12 |
| 1980-09-03 | @ NYA | 134 | L 3-8 | 65-69 | 3 | 27,091 | Brian Kingman | Tommy John | Tommy John | Brian Kingman | | 536 | 529 | 7 |
| 1980-09-04 | @ BAL | 135 | W 7-1 | 66-69 | 2 | 12,249 | Matt Keough | Mike Flanagan | Matt Keough | Mike Flanagan | | 543 | 530 | 13 |
| 1980-09-05 | @ BAL | 136 | L 7-8 | 66-70 | 3 | 24,587 | Mike Norris | Scott McGregor | Tim Stoddard | Jeff Jones | | 550 | 538 | 12 |
| 1980-09-06 | @ BAL | 137 | W 3-2 | 67-70 | 2 | 33,472 | Rick Langford | Jim Palmer | Rick Langford | Jim Palmer | | 553 | 540 | 13 |
| 1980-09-07 | @ BAL | 138 | W 5-2 | 68-70 | 2 | 22,529 | Steve McCatty | Steve Stone | Steve McCatty | Steve Stone | | 558 | 542 | 16 |
| 1980-09-08 | vs TEX | 139 | L 2-6 | 68-71 | 3 | 9,731 | Brian Kingman | John Butcher | John Butcher | Brian Kingman | | 560 | 548 | 12 |
| 1980-09-09 | vs TEX | 140 | W 6-3 | 69-71 | 2 | 2,443 | Matt Keough | Ed Figueroa | Matt Keough | Ed Figueroa | Jeff Jones | 566 | 551 | 15 |
| 1980-09-10 | vs TEX | 141 | W 3-1 | 70-71 | 2 | 3,598 | Mike Norris | Jon Matlack | Mike Norris | Jon Matlack | | 569 | 552 | 17 |
| 1980-09-12 | vs KCA | 142 | W 9-5 | 71-71 | 2 | 17,440 | Rick Langford | Rich Gale | Rick Langford | Craig Chamberlain | | 578 | 557 | 21 |
| 1980-09-13 | vs KCA | 143 | W 6-2 | 72-71 | 2 | 11,253 | Steve McCatty | Larry Gura | Steve McCatty | Larry Gura | | 584 | 559 | 25 |
| 1980-09-14 | vs KCA | 144 | L 3-4 | 72-72 | 2 | 10,756 | Brian Kingman | Paul Splittorff | Paul Splittorff | Brian Kingman | Dan Quisenberry | 587 | 563 | 24 |
| 1980-09-15 | @ TEX | 145 | L 0-2 | 72-73 | 2 | 6,941 | Matt Keough | Jon Matlack | Jon Matlack | Matt Keough | John Henry Johnson | 587 | 565 | 22 |
| 1980-09-16 | @ TEX | 146 | W 4-2 | 73-73 | 2 | 7,295 | Mike Norris | Doc Medich | Mike Norris | Danny Darwin | | 591 | 567 | 24 |
| 1980-09-17 | @ TEX | 147 | W 6-4 | 74-73 | 2 | 7,255 | Rick Langford | John Butcher | Rick Langford | John Butcher | Bob Lacey | 597 | 571 | 26 |
| 1980-09-18 | @ TEX | 148 | L 6-10 | 74-74 | 2 | 7,560 | Steve McCatty | Ken Clay | Danny Darwin | Steve McCatty | John Henry Johnson | 603 | 581 | 22 |
| 1980-09-19 | @ KCA | 149 | L 3-13 | 74-75 | 2 | 29,493 | Brian Kingman | Paul Splittorff | Paul Splittorff | Brian Kingman | | 606 | 594 | 12 |
| 1980-09-20 | @ KCA | 150 | W 9-0 | 75-75 | 2 | 37,523 | Matt Keough | Mike Jones | Matt Keough | Mike Jones | | 615 | 594 | 21 |
| 1980-09-21 | @ KCA | 151 | W 9-3 | 76-75 | 2 | 41,329 | Mike Norris | Dennis Leonard | Mike Norris | Dennis Leonard | | 624 | 597 | 27 |
| 1980-09-23 | vs CHA | 152 | W 6-4 | 77-75 | 2 | 3,069 | Rick Langford | Britt Burns | Rick Langford | Mike Proly | | 630 | 601 | 29 |
| 1980-09-24 | vs CHA | 153 | W 7-1 | 78-75 | 2 | 2,836 | Steve McCatty | Steve Trout | Steve McCatty | Steve Trout | | 637 | 602 | 35 |
| 1980-09-25 | vs CHA | 154 | L 4-6 | 78-76 | 2 | 3,180 | Matt Keough | Ross Baumgarten | Mike Proly | Brian Kingman | Ed Farmer | 641 | 608 | 33 |
| 1980-09-26 | vs MIL | 155 | L 7-10 | 78-77 | 2 | 5,099 | Mike Norris | Dave LaPoint | Reggie Cleveland | Mike Norris | Bob McClure | 648 | 618 | 30 |
| 1980-09-27 | vs MIL | 156 | W 7-4 | 79-77 | 2 | 4,581 | Rick Langford | Moose Haas | Rick Langford | Moose Haas | | 655 | 622 | 33 |
| 1980-09-28 | vs MIL | 157 | W 3-2 | 80-77 | 2 | 10,662 | Steve McCatty | Mike Caldwell | Steve McCatty | Reggie Cleveland | | 658 | 624 | 34 |
| 1980-09-30 | @ CHA | 158 | W 5-1 | 81-77 | 2 | 18,903 | Brian Kingman | Steve Trout | Brian Kingman | Steve Trout | Bob Lacey | 663 | 625 | 38 |
| 1980-10-01 | @ CHA | 159 | W 11-3 | 82-77 | 2 | 2,258 | Mike Norris | Ross Baumgarten | Mike Norris | Ross Baumgarten | | 674 | 628 | 46 |
| 1980-10-02 | @ CHA | 160 | L 4-9 | 82-78 | 2 | 2,202 | Rick Langford | Richard Dotson | Guy Hoffman | Rick Langford | | 678 | 637 | 41 |
| 1980-10-04 | @ MIL | 161 | W 4-0 | 83-78 | 2 | 9,116 | Bob Lacey | Moose Haas | Bob Lacey | Moose Haas | | 682 | 637 | 45 |
| 1980-10-05 | @ MIL | 162 | L 4-5 | 83-79 | 2 | 9,813 | Rick Langford | Mike Caldwell | Reggie Cleveland | Dave Beard | | 686 | 642 | 44 |