| 1979-04-04 | @ SEA | 1 | L 4-5 | 0-1 | 7 | 37,748 | Frank Tanana | Glenn Abbott | John Montague | Frank Tanana | | 4 | 5 | -1 |
| 1979-04-06 | @ SEA | 2 | L 6-14 | 0-2 | 7 | 8,831 | Nolan Ryan | Byron McLaughlin | Byron McLaughlin | Nolan Ryan | | 10 | 19 | -9 |
| 1979-04-07 | @ SEA | 3 | W 5-4 | 1-2 | 5 | 18,010 | Chris Knapp | Odell Jones | Mark Clear | Rick Honeycutt | Dave LaRoche | 15 | 23 | -8 |
| 1979-04-08 | @ SEA | 4 | W 7-5 | 2-2 | 5 | 9,183 | Don Aase | Paul Mitchell | Dave LaRoche | Shane Rawley | | 22 | 28 | -6 |
| 1979-04-10 | vs MIN | 5 | L 1-8 | 2-3 | 5 | 33,171 | Frank Tanana | Jerry Koosman | Jerry Koosman | Frank Tanana | Mike Marshall | 23 | 36 | -13 |
| 1979-04-11 | vs MIN | 6 | W 11-2 | 3-3 | 5 | 21,633 | Nolan Ryan | Dave Goltz | Nolan Ryan | Dave Goltz | | 34 | 38 | -4 |
| 1979-04-12 | vs MIN | 7 | W 7-1 | 4-3 | 5 | 22,211 | Chris Knapp | Roger Erickson | Chris Knapp | Roger Erickson | | 41 | 39 | 2 |
| 1979-04-13 | @ OAK | 8 | W 10-1 | 5-3 | 4 | 2,985 | Don Aase | John Henry Johnson | Don Aase | John Henry Johnson | | 51 | 40 | 11 |
| 1979-04-14 | @ OAK | 9 | W 9-3 | 6-3 | 3 | 2,649 | Dave Frost | Rick Langford | Dave Frost | Rick Langford | | 60 | 43 | 17 |
| 1979-04-15 | @ OAK | 10 | W 8-1 | 7-3 | 3 | 2,243 | Frank Tanana | Matt Keough | Frank Tanana | Matt Keough | | 68 | 44 | 24 |
| 1979-04-17 | @ MIN | 11 | W 6-0 | 8-3 | 2 | 37,529 | Nolan Ryan | Dave Goltz | Nolan Ryan | Dave Goltz | | 74 | 44 | 30 |
| 1979-04-18 | @ MIN | 12 | W 11-6 | 9-3 | 2 | 3,776 | Chris Knapp | Roger Erickson | Dyar Miller | Roger Erickson | Mark Clear | 85 | 50 | 35 |
| 1979-04-19 | @ MIN | 13 | W 6-4 | 10-3 | 2 | 3,537 | Don Aase | Paul Hartzell | Don Aase | Mike Marshall | Dave LaRoche | 91 | 54 | 37 |
| 1979-04-20 | vs OAK | 14 | W 7-4 | 11-3 | 1 | 27,417 | Frank Tanana | Rick Langford | Frank Tanana | Rick Langford | Dave Frost | 98 | 58 | 40 |
| 1979-04-21 | vs OAK | 15 | W 13-1 | 12-3 | 1 | 34,728 | Nolan Ryan | Matt Keough | Nolan Ryan | Matt Keough | | 111 | 59 | 52 |
| 1979-04-22 | vs OAK | 16 | L 6-7 | 12-4 | 1 | 36,130 | Chris Knapp | Mike Norris | Dave Heaverlo | Dave LaRoche | | 117 | 66 | 51 |
| 1979-04-24 | vs BAL | 17 | L 2-7 | 12-5 | 1 | 22,343 | Don Aase | Jim Palmer | Jim Palmer | Don Aase | | 119 | 73 | 46 |
| 1979-04-25 | vs BAL | 18 | L 2-5 | 12-6 | 2 | 19,939 | Frank Tanana | Steve Stone | Steve Stone | Frank Tanana | Don Stanhouse | 121 | 78 | 43 |
| 1979-04-26 | vs BAL | 19 | L 2-4 | 12-7 | 2 | 21,598 | Nolan Ryan | Dennis Martinez | Tim Stoddard | Dave LaRoche | | 123 | 82 | 41 |
| 1979-04-27 | vs BOS | 20 | W 8-6 | 13-7 | 1 | 29,408 | Chris Knapp | Mike Torrez | Mark Clear | Andy Hassler | | 131 | 88 | 43 |
| 1979-04-28 | vs BOS | 21 | W 5-0 | 14-7 | 1 | 41,954 | Dave Frost | Chuck Rainey | Dave Frost | Chuck Rainey | | 136 | 88 | 48 |
| 1979-04-29 | vs BOS | 22 | L 0-2 | 14-8 | 1 | 35,206 | Don Aase | Steve Renko | Steve Renko | Don Aase | Bill Campbell | 136 | 90 | 46 |
| 1979-04-30 | vs NYA | 23 | W 2-1 | 15-8 | 1 | 37,180 | Jim Barr | Ed Figueroa | Dave LaRoche | Ed Figueroa | | 138 | 91 | 47 |
| 1979-05-01 | vs NYA | 24 | L 8-12 | 15-9 | 2 | 38,858 | Frank Tanana | Luis Tiant | Tommy John | Dave LaRoche | | 146 | 103 | 43 |
| 1979-05-02 | vs NYA | 25 | W 1-0 | 16-9 | 2 | 40,648 | Nolan Ryan | Ron Guidry | Nolan Ryan | Ron Guidry | | 147 | 103 | 44 |
| 1979-05-05 | @ BAL | 26 | L 1-9 | 16-10 | 2 | 20,455 | Don Aase | Jim Palmer | Jim Palmer | Don Aase | | 148 | 112 | 36 |
| 1979-05-06 | @ BAL | 27 | L 0-6 | 16-11 | 2 | 25,630 | Frank Tanana | Dennis Martinez | Dennis Martinez | Mike Barlow | | 148 | 118 | 30 |
| 1979-05-07 | @ BOS | 28 | L 4-9 | 16-12 | 2 | 23,319 | Nolan Ryan | Mike Torrez | Mike Torrez | Nolan Ryan | | 152 | 127 | 25 |
| 1979-05-08 | @ BOS | 29 | W 10-2 | 17-12 | 2 | 21,160 | Chris Knapp | Chuck Rainey | Chris Knapp | Chuck Rainey | | 162 | 129 | 33 |
| 1979-05-09 | @ BOS | 30 | L 8-9 | 17-13 | 2 | 24,815 | Dave Frost | Steve Renko | Bill Campbell | Dave LaRoche | | 170 | 138 | 32 |
| 1979-05-10 | @ BOS | 31 | W 5-3 | 18-13 | 2 | 24,990 | Don Aase | Dennis Eckersley | Don Aase | Dennis Eckersley | Mark Clear | 175 | 141 | 34 |
| 1979-05-11 | @ NYA | 32 | W 4-1 | 19-13 | 2 | 37,988 | Jim Barr | Catfish Hunter | Jim Barr | Catfish Hunter | | 179 | 142 | 37 |
| 1979-05-12 | @ NYA | 33 | L 5-6 | 19-14 | 2 | 28,783 | Dyar Miller | Luis Tiant | Dick Tidrow | Dave Frost | | 184 | 148 | 36 |
| 1979-05-13 | @ NYA | 34 | L 10-12 | 19-15 | 3 | 30,083 | Chris Knapp | Jim Beattie | Jim Beattie | Chris Knapp | | 194 | 160 | 34 |
| 1979-05-15 | vs MIL | 35 | W 2-1 | 20-15 | 3 | 21,235 | Nolan Ryan | Mike Caldwell | Mark Clear | Mike Caldwell | | 196 | 161 | 35 |
| 1979-05-16 | vs MIL | 36 | W 4-3 | 21-15 | 3 | 21,533 | Dave Frost | Jim Slaton | Mark Clear | Jerry Augustine | | 200 | 164 | 36 |
| 1979-05-17 | vs MIL | 37 | W 8-5 | 22-15 | 3 | 22,060 | Don Aase | Lary Sorensen | Jim Barr | Lary Sorensen | Dave LaRoche | 208 | 169 | 39 |
| 1979-05-18 | vs CHA | 38 | W 7-3 | 23-15 | 2 | 25,598 | Frank Tanana | Ron Schueler | Frank Tanana | Ron Schueler | Mark Clear | 215 | 172 | 43 |
| 1979-05-19 | vs CHA | 39 | W 10-6 | 24-15 | 2 | 41,941 | Chris Knapp | Rich Wortham | Chris Knapp | Rich Wortham | Dave LaRoche | 225 | 178 | 47 |
| 1979-05-20 | vs CHA | 40 | W 4-0 | 25-15 | 2 | 27,189 | Nolan Ryan | Ross Baumgarten | Nolan Ryan | Ross Baumgarten | | 229 | 178 | 51 |
| 1979-05-22 | @ MIL | 41 | L 1-7 | 25-16 | 2 | 9,857 | Dave Frost | Lary Sorensen | Lary Sorensen | Dave Frost | | 230 | 185 | 45 |
| 1979-05-23 | @ MIL | 42 | L 0-1 | 25-17 | 2 | 8,408 | Don Aase | Bill Travers | Bill Travers | Don Aase | | 230 | 186 | 44 |
| 1979-05-24 | @ MIL | 43 | L 6-9 | 25-18 | 3 | 16,314 | Chris Knapp | Moose Haas | Jerry Augustine | Chris Knapp | | 236 | 195 | 41 |
| 1979-05-25 | @ CHA | 44 | L 1-6 | 25-19 | 2 | 20,554 | Nolan Ryan | Ross Baumgarten | Ross Baumgarten | Nolan Ryan | | 237 | 201 | 36 |
| 1979-05-26 | @ CHA | 45 | W 8-4 | 26-19 | 2 | 31,576 | Frank Tanana | Fred Howard | Frank Tanana | Fred Howard | Mark Clear | 245 | 205 | 40 |
| 1979-05-27 | @ CHA | 46 | W 4-2 | 28-19 | 1 | 0 | Dave Frost | Francisco Barrios | Dave Frost | Francisco Barrios | | 249 | 207 | 42 |
| 1979-05-27 | @ CHA | 47 | W 9-1 | 28-19 | 1 | 25,025 | Don Aase | Rich Hinton | Don Aase | Rich Hinton | | 258 | 208 | 50 |
| 1979-05-29 | @ SEA | 48 | W 6-4 | 29-19 | 1 | 4,068 | Jim Barr | Mike Parrott | Jim Barr | Mike Parrott | Dave LaRoche | 264 | 212 | 52 |
| 1979-05-30 | @ SEA | 49 | W 3-2 | 30-19 | 1 | 5,206 | Nolan Ryan | Rick Honeycutt | Nolan Ryan | Shane Rawley | | 267 | 214 | 53 |
| 1979-05-31 | @ SEA | 50 | L 10-12 | 30-20 | 1 | 5,266 | Frank Tanana | Glenn Abbott | Byron McLaughlin | Mark Clear | Shane Rawley | 277 | 226 | 51 |
| 1979-06-01 | vs CLE | 51 | L 4-7 | 30-21 | 2 | 20,070 | Dave Frost | Rick Wise | Rick Wise | Dave Frost | Victor Cruz | 281 | 233 | 48 |
| 1979-06-02 | vs CLE | 52 | W 5-2 | 31-21 | 1 | 41,969 | Don Aase | Wayne Garland | Mark Clear | Wayne Garland | | 286 | 235 | 51 |
| 1979-06-03 | vs CLE | 53 | L 3-5 | 31-22 | 2 | 24,409 | Jim Barr | Mike Paxton | Mike Paxton | Jim Barr | | 289 | 240 | 49 |
| 1979-06-04 | vs TOR | 54 | W 4-2 | 32-22 | 1 | 16,979 | Chris Knapp | Phil Huffman | Mike Barlow | Phil Huffman | Mark Clear | 293 | 242 | 51 |
| 1979-06-05 | vs TOR | 55 | W 3-0 | 33-22 | 1 | 18,862 | Frank Tanana | Tom Underwood | Frank Tanana | Tom Underwood | | 296 | 242 | 54 |
| 1979-06-06 | vs TOR | 56 | L 4-5 | 33-23 | 1 | 18,835 | Dave Frost | Jesse Jefferson | Jesse Jefferson | Dave LaRoche | | 300 | 247 | 53 |
| 1979-06-08 | vs DET | 57 | W 6-4 | 34-23 | 1 | 28,298 | Don Aase | Milt Wilcox | Don Aase | Milt Wilcox | Mark Clear | 306 | 251 | 55 |
| 1979-06-09 | vs DET | 58 | W 9-1 | 35-23 | 1 | 36,499 | Nolan Ryan | Dave Rozema | Nolan Ryan | Dave Rozema | | 315 | 252 | 63 |
| 1979-06-10 | vs DET | 59 | L 7-10 | 35-24 | 1 | 30,229 | Frank Tanana | Jack Billingham | Fernando Arroyo | Frank Tanana | John Hiller | 322 | 262 | 60 |
| 1979-06-11 | @ CLE | 60 | W 9-4 | 36-24 | 1 | 10,674 | Jim Barr | Eric Wilkins | Mark Clear | Dan Spillner | | 331 | 266 | 65 |
| 1979-06-12 | @ CLE | 61 | L 10-11 | 36-25 | 1 | 9,945 | Dave Frost | Rick Wise | Don Hood | Mark Clear | | 341 | 277 | 64 |
| 1979-06-13 | @ TOR | 62 | L 8-9 | 37-26 | 1 | 0 | Steve Eddy | Balor Moore | Dave Freisleben | Dave LaRoche | | 349 | 286 | 63 |
| 1979-06-13 | @ TOR | 63 | W 10-2 | 37-26 | 1 | 28,577 | Don Aase | Mike Willis | Don Aase | Mike Willis | | 359 | 288 | 71 |
| 1979-06-14 | @ TOR | 64 | W 10-2 | 38-26 | 1 | 15,097 | Nolan Ryan | Phil Huffman | Nolan Ryan | Phil Huffman | | 369 | 290 | 79 |
| 1979-06-15 | @ DET | 65 | W 8-7 | 39-26 | 1 | 41,151 | Jim Barr | Dave Rozema | Mark Clear | Dave Tobik | | 377 | 297 | 80 |
| 1979-06-16 | @ DET | 66 | W 4-2 | 40-26 | 1 | 39,240 | Dave Frost | Jack Morris | Dave Frost | Jack Morris | Dave LaRoche | 381 | 299 | 82 |
| 1979-06-17 | @ DET | 67 | L 4-8 | 40-27 | 1 | 32,744 | Don Aase | Pat Underwood | Aurelio Lopez | Don Aase | | 385 | 307 | 78 |
| 1979-06-18 | vs TEX | 68 | W 5-0 | 41-27 | 1 | 37,096 | Nolan Ryan | Fergie Jenkins | Nolan Ryan | Fergie Jenkins | | 390 | 307 | 83 |
| 1979-06-19 | vs TEX | 69 | L 1-2 | 41-28 | 1 | 26,553 | Jim Barr | John Henry Johnson | John Henry Johnson | Jim Barr | Jim Kern | 391 | 309 | 82 |
| 1979-06-20 | vs TEX | 70 | W 5-4 | 42-28 | 1 | 26,895 | Dave Frost | Jon Matlack | Dave Frost | Jon Matlack | Mark Clear | 396 | 313 | 83 |
| 1979-06-21 | vs TEX | 71 | L 2-3 | 42-29 | 1 | 26,422 | Don Aase | Danny Darwin | Sparky Lyle | Dave LaRoche | | 398 | 316 | 82 |
| 1979-06-22 | vs KCA | 72 | L 5-9 | 42-30 | 1 | 30,737 | Nolan Ryan | Rich Gale | Rich Gale | Nolan Ryan | | 403 | 325 | 78 |
| 1979-06-23 | vs KCA | 73 | L 4-13 | 42-31 | 1 | 41,002 | Jim Barr | Larry Gura | Larry Gura | Jim Barr | Eduardo Rodriguez | 407 | 338 | 69 |
| 1979-06-24 | vs KCA | 74 | L 2-5 | 42-32 | 1 | 32,210 | Dave Frost | Dennis Leonard | Dennis Leonard | Dave Frost | | 409 | 343 | 66 |
| 1979-06-26 | @ TEX | 75 | L 1-2 | 42-33 | 1 | 28,695 | Don Aase | Jon Matlack | Jon Matlack | Don Aase | Jim Kern | 410 | 345 | 65 |
| 1979-06-27 | @ TEX | 76 | L 2-4 | 42-34 | 3 | 28,899 | Nolan Ryan | Steve Comer | Steve Comer | Nolan Ryan | Jim Kern | 412 | 349 | 63 |
| 1979-06-28 | @ TEX | 77 | L 4-14 | 42-35 | 3 | 29,101 | Jim Barr | Fergie Jenkins | Fergie Jenkins | Jim Barr | | 416 | 363 | 53 |
| 1979-06-29 | @ KCA | 78 | W 6-5 | 43-35 | 3 | 36,705 | Dave Frost | Dennis Leonard | Mark Clear | Marty Pattin | Dave LaRoche | 422 | 368 | 54 |
| 1979-06-30 | @ KCA | 79 | W 8-5 | 44-35 | 2 | 41,451 | Don Aase | Rich Gale | Don Aase | Rich Gale | Dave LaRoche | 430 | 373 | 57 |
| 1979-07-01 | @ KCA | 80 | W 14-2 | 45-35 | 2 | 32,636 | Nolan Ryan | Paul Splittorff | Nolan Ryan | Paul Splittorff | | 444 | 375 | 69 |
| 1979-07-02 | vs OAK | 81 | W 8-3 | 46-35 | 2 | 27,639 | Jim Barr | Mike Morgan | Jim Barr | Mike Morgan | | 452 | 378 | 74 |
| 1979-07-03 | vs OAK | 82 | W 3-0 | 47-35 | 2 | 22,498 | Dave Frost | Brian Kingman | Dave Frost | Brian Kingman | | 455 | 378 | 77 |
| 1979-07-04 | vs OAK | 83 | W 17-6 | 48-35 | 2 | 41,958 | Don Aase | Matt Keough | Mark Clear | Dave Heaverlo | | 472 | 384 | 88 |
| 1979-07-05 | vs OAK | 84 | L 0-3 | 48-36 | 2 | 23,793 | Nolan Ryan | Rick Langford | Rick Langford | Nolan Ryan | | 472 | 387 | 85 |
| 1979-07-06 | vs BAL | 85 | W 7-3 | 49-36 | 1 | 24,679 | Jim Barr | Steve Stone | Jim Barr | Steve Stone | | 479 | 390 | 89 |
| 1979-07-07 | vs BAL | 86 | W 10-1 | 50-36 | 1 | 37,382 | Dave Frost | Dennis Martinez | Dave Frost | Dennis Martinez | | 489 | 391 | 98 |
| 1979-07-08 | vs BAL | 87 | L 2-3 | 50-37 | 2 | 29,062 | Don Aase | Scott McGregor | Scott McGregor | Don Aase | Don Stanhouse | 491 | 394 | 97 |
| 1979-07-09 | vs BOS | 88 | W 6-0 | 51-37 | 1 | 27,692 | Nolan Ryan | Mike Torrez | Nolan Ryan | Mike Torrez | | 497 | 394 | 103 |
| 1979-07-10 | vs BOS | 89 | W 4-3 | 52-37 | 1 | 36,619 | Jim Barr | Bob Stanley | Jim Barr | Bob Stanley | Mark Clear | 501 | 397 | 104 |
| 1979-07-11 | vs BOS | 90 | L 3-9 | 52-38 | 1 | 39,210 | Dave Frost | Dennis Eckersley | Dennis Eckersley | Dave Frost | | 504 | 406 | 98 |
| 1979-07-13 | vs NYA | 91 | W 6-1 | 53-38 | 1 | 41,805 | Nolan Ryan | Luis Tiant | Nolan Ryan | Luis Tiant | | 510 | 407 | 103 |
| 1979-07-14 | vs NYA | 92 | W 8-7 | 54-38 | 1 | 41,693 | Don Aase | Tommy John | Mark Clear | Ron Davis | | 518 | 414 | 104 |
| 1979-07-15 | vs NYA | 93 | W 5-4 | 55-38 | 1 | 40,739 | Dave Frost | Ron Guidry | Jim Barr | Ron Guidry | | 523 | 418 | 105 |
| 1979-07-19 | @ BAL | 94 | W 4-3 | 56-39 | 1 | 0 | Don Aase | Dennis Martinez | Dave LaRoche | Dennis Martinez | | 527 | 421 | 106 |
| 1979-07-19 | @ BAL | 95 | L 0-3 | 56-39 | 1 | 33,603 | Dave Frost | Mike Flanagan | Mike Flanagan | Dave Frost | | 527 | 424 | 103 |
| 1979-07-20 | @ BAL | 96 | L 1-2 | 56-40 | 1 | 25,682 | Jim Barr | Scott McGregor | Scott McGregor | Jim Barr | | 528 | 426 | 102 |
| 1979-07-21 | @ BAL | 97 | L 2-10 | 56-41 | 1 | 51,381 | Nolan Ryan | Sammy Stewart | Sammy Stewart | Nolan Ryan | | 530 | 436 | 94 |
| 1979-07-22 | @ BOS | 98 | L 5-6 | 56-42 | 1 | 35,172 | Steve Eddy | Bob Stanley | Bill Campbell | Mark Clear | | 535 | 442 | 93 |
| 1979-07-23 | @ BOS | 99 | W 9-2 | 57-42 | 1 | 35,024 | Dave Frost | Joel Finch | Dave Frost | Joel Finch | | 544 | 444 | 100 |
| 1979-07-24 | @ NYA | 100 | L 5-6 | 57-43 | 1 | 33,497 | Don Aase | Luis Tiant | Ron Davis | Dave LaRoche | Rich Gossage | 549 | 450 | 99 |
| 1979-07-25 | @ NYA | 101 | W 9-5 | 58-43 | 1 | 47,449 | Nolan Ryan | Tommy John | Ralph Botting | Tommy John | Mark Clear | 558 | 455 | 103 |
| 1979-07-26 | @ NYA | 102 | L 0-2 | 58-44 | 1 | 43,136 | Jim Barr | Ron Guidry | Ron Guidry | Jim Barr | | 558 | 457 | 101 |
| 1979-07-27 | vs MIN | 103 | L 1-3 | 58-45 | 1 | 38,945 | Dave Frost | Geoff Zahn | Geoff Zahn | Dave Frost | Mike Marshall | 559 | 460 | 99 |
| 1979-07-28 | vs MIN | 104 | W 5-0 | 59-45 | 1 | 41,891 | Don Aase | Jerry Koosman | Don Aase | Jerry Koosman | | 564 | 460 | 104 |
| 1979-07-29 | vs MIN | 105 | W 9-3 | 60-45 | 1 | 33,510 | Steve Eddy | Darrell Jackson | Steve Eddy | Darrell Jackson | Dave LaRoche | 573 | 463 | 110 |
| 1979-07-30 | vs SEA | 106 | L 0-8 | 60-46 | 1 | 35,584 | Jim Barr | Mike Parrott | Mike Parrott | Jim Barr | | 573 | 471 | 102 |
| 1979-07-31 | vs SEA | 107 | W 8-1 | 61-46 | 1 | 25,198 | Dave Frost | Rob Dressler | Dave Frost | Rob Dressler | | 581 | 472 | 109 |
| 1979-08-01 | vs SEA | 108 | L 6-7 | 61-47 | 1 | 29,446 | Don Aase | Rick Honeycutt | Randy Stein | Dave LaRoche | | 587 | 479 | 108 |
| 1979-08-03 | @ MIN | 109 | L 1-4 | 61-48 | 1 | 30,653 | Jim Barr | Jerry Koosman | Jerry Koosman | Jim Barr | Mike Marshall | 588 | 483 | 105 |
| 1979-08-04 | @ MIN | 110 | W 7-1 | 62-48 | 1 | 26,084 | Dave Frost | Dave Goltz | Dave Frost | Dave Goltz | Mark Clear | 595 | 484 | 111 |
| 1979-08-05 | @ MIN | 111 | W 11-7 | 63-49 | 1 | 0 | Don Aase | Geoff Zahn | Dave LaRoche | Roger Erickson | Mark Clear | 606 | 491 | 115 |
| 1979-08-05 | @ MIN | 112 | L 1-7 | 63-49 | 1 | 41,182 | Steve Eddy | Pete Redfern | Pete Redfern | Steve Eddy | Mike Marshall | 607 | 498 | 109 |
| 1979-08-06 | @ OAK | 113 | W 5-2 | 64-49 | 1 | 8,160 | Ralph Botting | Steve McCatty | Ralph Botting | Steve McCatty | Mark Clear | 612 | 500 | 112 |
| 1979-08-07 | @ OAK | 114 | L 5-9 | 64-50 | 1 | 2,905 | Jim Barr | Rick Langford | Rick Langford | Jim Barr | | 617 | 509 | 108 |
| 1979-08-08 | @ OAK | 115 | W 8-1 | 65-50 | 1 | 3,463 | Dave Frost | Matt Keough | Dave Frost | Matt Keough | | 625 | 510 | 115 |
| 1979-08-10 | vs SEA | 116 | L 6-8 | 65-51 | 1 | 28,969 | Don Aase | Mike Parrott | Randy Stein | Dave LaRoche | | 631 | 518 | 113 |
| 1979-08-11 | vs SEA | 117 | W 8-1 | 66-51 | 1 | 41,940 | Jim Barr | Rick Honeycutt | Jim Barr | Rick Honeycutt | | 639 | 519 | 120 |
| 1979-08-12 | vs SEA | 118 | W 4-3 | 67-51 | 1 | 27,345 | Dave Frost | Rob Dressler | Dave Frost | Randy Stein | | 643 | 522 | 121 |
| 1979-08-13 | vs DET | 119 | L 3-5 | 67-52 | 1 | 34,032 | Nolan Ryan | Jack Morris | Jack Morris | Nolan Ryan | Aurelio Lopez | 646 | 527 | 119 |
| 1979-08-14 | vs DET | 120 | L 3-6 | 67-53 | 1 | 29,465 | Don Aase | Bruce Robbins | Bruce Robbins | Don Aase | Jack Billingham | 649 | 533 | 116 |
| 1979-08-15 | vs DET | 121 | L 1-6 | 67-54 | 1 | 31,885 | Jim Barr | Dan Petry | Dan Petry | Jim Barr | | 650 | 539 | 111 |
| 1979-08-17 | vs TOR | 122 | L 5-6 | 67-55 | 1 | 25,050 | Dave Frost | Dave Stieb | Dave Stieb | Mark Clear | | 655 | 545 | 110 |
| 1979-08-18 | vs TOR | 123 | W 7-5 | 68-55 | 1 | 30,361 | Nolan Ryan | Tom Underwood | Nolan Ryan | Tom Underwood | Mark Clear | 662 | 550 | 112 |
| 1979-08-19 | vs TOR | 124 | W 4-2 | 69-55 | 1 | 23,814 | Chris Knapp | Balor Moore | Don Aase | Balor Moore | | 666 | 552 | 114 |
| 1979-08-20 | vs CLE | 125 | W 6-5 | 70-55 | 1 | 35,497 | Jim Barr | Len Barker | Dave LaRoche | Sid Monge | | 672 | 557 | 115 |
| 1979-08-21 | vs CLE | 126 | L 7-12 | 70-56 | 1 | 30,902 | Dave Frost | Mike Paxton | Paul Reuschel | Dave Frost | | 679 | 569 | 110 |
| 1979-08-22 | vs CLE | 127 | L 3-13 | 70-57 | 1 | 30,625 | Nolan Ryan | Dan Spillner | Dan Spillner | Nolan Ryan | | 682 | 582 | 100 |
| 1979-08-24 | @ TOR | 128 | L 4-6 | 70-58 | 1 | 18,077 | Chris Knapp | Tom Underwood | Tom Underwood | Chris Knapp | Tom Buskey | 686 | 588 | 98 |
| 1979-08-25 | @ TOR | 129 | W 24-2 | 71-58 | 1 | 25,207 | Dave Frost | Balor Moore | Dave Frost | Balor Moore | | 710 | 590 | 120 |
| 1979-08-26 | @ TOR | 130 | L 3-9 | 71-59 | 1 | 22,619 | Nolan Ryan | Butch Edge | Butch Edge | Nolan Ryan | | 713 | 599 | 114 |
| 1979-08-27 | @ DET | 131 | L 2-3 | 71-60 | 1 | 22,874 | Jim Barr | Jack Billingham | Jack Billingham | Jim Barr | Aurelio Lopez | 715 | 602 | 113 |
| 1979-08-28 | @ DET | 132 | L 2-12 | 71-61 | 1 | 19,178 | Don Aase | Bruce Robbins | Bruce Robbins | Don Aase | | 717 | 614 | 103 |
| 1979-08-29 | @ DET | 133 | L 1-2 | 71-62 | 1 | 19,880 | Dave Frost | Jack Morris | Jack Morris | Dave Frost | Aurelio Lopez | 718 | 616 | 102 |
| 1979-08-30 | @ CLE | 134 | L 1-7 | 71-63 | 2 | 8,647 | Nolan Ryan | Len Barker | Len Barker | Nolan Ryan | | 719 | 623 | 96 |
| 1979-08-31 | @ CLE | 135 | W 9-8 | 72-63 | 1 | 10,501 | Chris Knapp | Mike Paxton | Mark Clear | Paul Reuschel | John Montague | 728 | 631 | 97 |
| 1979-09-01 | @ CLE | 136 | W 7-4 | 73-63 | 1 | 22,804 | Jim Barr | Dan Spillner | Dave LaRoche | Wayne Garland | John Montague | 735 | 635 | 100 |
| 1979-09-02 | @ CLE | 137 | W 5-2 | 74-63 | 1 | 6,359 | Dave Frost | Rick Waits | Dave Frost | Rick Waits | Mark Clear | 740 | 637 | 103 |
| 1979-09-03 | vs CHA | 138 | W 6-5 | 75-63 | 1 | 34,684 | Nolan Ryan | Ross Baumgarten | Nolan Ryan | Ross Baumgarten | John Montague | 746 | 642 | 104 |
| 1979-09-04 | vs CHA | 139 | L 7-10 | 75-64 | 1 | 26,036 | Frank Tanana | Richard Dotson | Mike Proly | Jim Barr | Ed Farmer | 753 | 652 | 101 |
| 1979-09-05 | vs CHA | 140 | W 9-8 | 76-64 | 1 | 23,705 | Chris Knapp | Rich Wortham | John Montague | Randy Scarbery | Dave LaRoche | 762 | 660 | 102 |
| 1979-09-06 | vs CHA | 141 | W 10-9 | 77-64 | 1 | 20,930 | Dave Frost | Steve Trout | John Montague | Ed Farmer | | 772 | 669 | 103 |
| 1979-09-07 | vs MIL | 142 | W 6-3 | 78-64 | 1 | 30,685 | Nolan Ryan | Bill Travers | Nolan Ryan | Bill Travers | | 778 | 672 | 106 |
| 1979-09-08 | vs MIL | 143 | W 3-2 | 79-64 | 1 | 37,624 | Jim Barr | Lary Sorensen | Jim Barr | Jerry Augustine | John Montague | 781 | 674 | 107 |
| 1979-09-09 | vs MIL | 144 | W 5-2 | 80-64 | 1 | 27,341 | Frank Tanana | Moose Haas | Frank Tanana | Moose Haas | John Montague | 786 | 676 | 110 |
| 1979-09-11 | @ CHA | 145 | L 7-8 | 80-65 | 1 | 6,858 | Nolan Ryan | Rich Wortham | Ed Farmer | Don Aase | | 793 | 684 | 109 |
| 1979-09-12 | @ CHA | 146 | L 5-11 | 80-66 | 1 | 7,511 | Chris Knapp | Ken Kravec | Ken Kravec | Chris Knapp | Mike Proly | 798 | 695 | 103 |
| 1979-09-14 | @ MIL | 147 | W 8-7 | 81-66 | 1 | 17,840 | Jim Barr | Lary Sorensen | Dave LaRoche | Bill Castro | Don Aase | 806 | 702 | 104 |
| 1979-09-15 | @ MIL | 148 | L 2-3 | 81-67 | 1 | 45,732 | Nolan Ryan | Moose Haas | Moose Haas | Nolan Ryan | | 808 | 705 | 103 |
| 1979-09-16 | @ MIL | 149 | L 1-2 | 81-68 | 1 | 19,906 | Frank Tanana | Jim Slaton | Jim Slaton | Frank Tanana | | 809 | 707 | 102 |
| 1979-09-17 | @ KCA | 150 | L 4-16 | 81-69 | 1 | 38,327 | Chris Knapp | Dennis Leonard | Dennis Leonard | Chris Knapp | | 813 | 723 | 90 |
| 1979-09-18 | @ KCA | 151 | W 6-4 | 82-69 | 1 | 29,733 | Dave Frost | Rich Gale | Dave Frost | Rich Gale | John Montague | 819 | 727 | 92 |
| 1979-09-19 | @ KCA | 152 | L 4-6 | 82-70 | 1 | 31,412 | Nolan Ryan | Larry Gura | Larry Gura | Nolan Ryan | Dan Quisenberry | 823 | 733 | 90 |
| 1979-09-20 | @ KCA | 153 | W 11-6 | 83-70 | 1 | 32,659 | Jim Barr | Craig Chamberlain | Jim Barr | Craig Chamberlain | Don Aase | 834 | 739 | 95 |
| 1979-09-21 | vs TEX | 154 | L 1-3 | 83-71 | 1 | 37,450 | Frank Tanana | Doc Medich | Doc Medich | Mark Clear | Jim Kern | 835 | 742 | 93 |
| 1979-09-22 | vs TEX | 155 | W 3-1 | 84-71 | 1 | 33,730 | Chris Knapp | Steve Comer | Chris Knapp | Steve Comer | | 838 | 743 | 95 |
| 1979-09-23 | vs TEX | 156 | W 6-1 | 85-71 | 1 | 41,498 | Dave Frost | Fergie Jenkins | Dave Frost | Fergie Jenkins | | 844 | 744 | 100 |
| 1979-09-24 | vs KCA | 157 | W 4-3 | 86-71 | 1 | 40,423 | Nolan Ryan | Larry Gura | Nolan Ryan | Larry Gura | | 848 | 747 | 101 |
| 1979-09-25 | vs KCA | 158 | W 4-1 | 87-71 | 1 | 40,631 | Frank Tanana | Craig Chamberlain | Frank Tanana | Craig Chamberlain | | 852 | 748 | 104 |
| 1979-09-26 | vs KCA | 159 | L 0-4 | 87-72 | 1 | 40,565 | Dave LaRoche | Dennis Leonard | Dennis Leonard | Dave LaRoche | | 852 | 752 | 100 |
| 1979-09-28 | @ TEX | 160 | L 0-5 | 87-73 | 1 | 11,965 | Nolan Ryan | Fergie Jenkins | Fergie Jenkins | Nolan Ryan | | 852 | 757 | 95 |
| 1979-09-29 | @ TEX | 161 | L 3-6 | 87-74 | 1 | 19,167 | Dave Frost | Doc Medich | Dave Rajsich | Dave Frost | Jim Kern | 855 | 763 | 92 |
| 1979-09-30 | @ TEX | 162 | W 11-5 | 88-74 | 1 | 9,086 | Chris Knapp | Steve Comer | Chris Knapp | Steve Comer | | 866 | 768 | 98 |