| 1979-04-06 | @ HOU | 1 | L 1-2 | 0-1 | 5 | 28,998 | Phil Niekro | J.R. Richard | J.R. Richard | Phil Niekro | Joaquin Andujar | 1 | 2 | -1 |
| 1979-04-07 | @ HOU | 2 | L 0-6 | 0-2 | 5 | 24,325 | Larry McWilliams | Ken Forsch | Ken Forsch | Larry McWilliams | | 1 | 8 | -7 |
| 1979-04-08 | @ HOU | 3 | L 0-2 | 0-3 | 6 | 16,501 | Rick Matula | Joe Niekro | Joe Niekro | Rick Matula | | 1 | 10 | -9 |
| 1979-04-09 | vs CIN | 4 | L 4-9 | 0-4 | 6 | 30,433 | Mickey Mahler | Tom Seaver | Tom Seaver | Mickey Mahler | | 5 | 19 | -14 |
| 1979-04-10 | vs CIN | 5 | W 6-4 | 1-4 | 5 | 5,624 | Phil Niekro | Fred Norman | Phil Niekro | Fred Norman | Gene Garber | 11 | 23 | -12 |
| 1979-04-11 | vs CIN | 6 | L 5-9 | 1-5 | 6 | 3,021 | Eddie Solomon | Tom Hume | Tom Hume | Eddie Solomon | Frank Pastore | 16 | 32 | -16 |
| 1979-04-12 | @ LAN | 7 | W 10-2 | 2-5 | 5 | 27,510 | Larry McWilliams | Andy Messersmith | Larry McWilliams | Andy Messersmith | | 26 | 34 | -8 |
| 1979-04-13 | @ LAN | 8 | W 2-1 | 3-5 | 5 | 42,284 | Rick Matula | Doug Rau | Rick Matula | Doug Rau | Gene Garber | 28 | 35 | -7 |
| 1979-04-14 | @ LAN | 9 | L 5-6 | 3-6 | 5 | 47,064 | Phil Niekro | Bob Welch | Bob Welch | Phil Niekro | Jerry Reuss | 33 | 41 | -8 |
| 1979-04-15 | @ LAN | 10 | W 11-4 | 4-6 | 5 | 32,799 | Eddie Solomon | Burt Hooton | Eddie Solomon | Burt Hooton | Gene Garber | 44 | 45 | -1 |
| 1979-04-17 | @ CIN | 11 | L 4-7 | 4-7 | 6 | 16,211 | Larry McWilliams | Tom Hume | Tom Hume | Larry McWilliams | Doug Bair | 48 | 52 | -4 |
| 1979-04-19 | @ CIN | 12 | L 0-2 | 4-8 | 6 | 16,182 | Phil Niekro | Tom Seaver | Tom Seaver | Phil Niekro | | 48 | 54 | -6 |
| 1979-04-20 | vs SDN | 13 | L 4-7 | 4-9 | 6 | 10,205 | Rick Matula | Randy Jones | Randy Jones | Rick Matula | | 52 | 61 | -9 |
| 1979-04-21 | vs SDN | 14 | L 5-9 | 4-10 | 6 | 28,950 | Eddie Solomon | Eric Rasmussen | John D'Acquisto | Gene Garber | | 57 | 70 | -13 |
| 1979-04-22 | vs SDN | 15 | W 8-7 | 5-10 | 6 | 4,513 | Larry McWilliams | Steve Mura | Gene Garber | Rollie Fingers | | 65 | 77 | -12 |
| 1979-04-23 | vs SLN | 16 | L 2-3 | 5-11 | 6 | 4,725 | Phil Niekro | Pete Vuckovich | Mark Littell | Phil Niekro | | 67 | 80 | -13 |
| 1979-04-24 | vs SLN | 17 | L 5-6 | 5-12 | 6 | 1,643 | Mickey Mahler | Bob Forsch | Mark Littell | Gene Garber | Buddy Schultz | 72 | 86 | -14 |
| 1979-04-27 | vs CHN | 18 | W 3-2 | 6-12 | 6 | 12,930 | Phil Niekro | Mike Krukow | Phil Niekro | Donnie Moore | | 75 | 88 | -13 |
| 1979-04-28 | vs CHN | 19 | W 7-2 | 7-12 | 6 | 18,785 | Rick Matula | Rick Reuschel | Rick Matula | Rick Reuschel | Gene Garber | 82 | 90 | -8 |
| 1979-04-29 | vs CHN | 20 | L 5-6 | 7-13 | 6 | 5,041 | Larry McWilliams | Dennis Lamp | Lynn McGlothen | Gene Garber | Bruce Sutter | 87 | 96 | -9 |
| 1979-05-01 | @ PIT | 21 | W 5-2 | 8-13 | 6 | 5,122 | Phil Niekro | Bert Blyleven | Phil Niekro | Kent Tekulve | | 92 | 98 | -6 |
| 1979-05-02 | @ PIT | 22 | L 2-10 | 8-14 | 6 | 4,840 | Mickey Mahler | John Candelaria | John Candelaria | Mickey Mahler | | 94 | 108 | -14 |
| 1979-05-04 | @ CHN | 23 | L 2-6 | 8-15 | 6 | 3,928 | Rick Matula | Mike Krukow | Mike Krukow | Rick Matula | Lynn McGlothen | 96 | 114 | -18 |
| 1979-05-05 | @ CHN | 24 | L 3-9 | 8-16 | 6 | 16,312 | Phil Niekro | Dennis Lamp | Dennis Lamp | Phil Niekro | | 99 | 123 | -24 |
| 1979-05-06 | @ CHN | 25 | L 13-14 | 8-17 | 6 | 21,984 | Larry McWilliams | Rick Reuschel | Bruce Sutter | Gene Garber | | 112 | 137 | -25 |
| 1979-05-07 | vs PIT | 26 | L 2-4 | 8-18 | 6 | 8,166 | Mickey Mahler | John Candelaria | John Candelaria | Mickey Mahler | Kent Tekulve | 114 | 141 | -27 |
| 1979-05-08 | vs PIT | 27 | W 4-1 | 9-18 | 6 | 5,741 | Eddie Solomon | Rick Rhoden | Eddie Solomon | Rick Rhoden | | 118 | 142 | -24 |
| 1979-05-09 | vs PIT | 28 | L 9-17 | 9-19 | 6 | 6,855 | Phil Niekro | Don Robinson | Jim Bibby | Gene Garber | Kent Tekulve | 127 | 159 | -32 |
| 1979-05-11 | @ SLN | 29 | W 3-0 | 10-19 | 6 | 9,209 | Larry McWilliams | Bob Forsch | Adrian Devine | Bob Forsch | Gene Garber | 130 | 159 | -29 |
| 1979-05-12 | @ SLN | 30 | L 6-7 | 10-20 | 6 | 16,011 | Mickey Mahler | Silvio Martinez | Buddy Schultz | Gene Garber | | 136 | 166 | -30 |
| 1979-05-13 | @ SLN | 31 | L 3-7 | 10-21 | 6 | 16,762 | Phil Niekro | Pete Vuckovich | Pete Vuckovich | Phil Niekro | | 139 | 173 | -34 |
| 1979-05-15 | vs LAN | 32 | L 4-5 | 10-22 | 6 | 8,139 | Rick Matula | Don Sutton | Bob Welch | Adrian Devine | | 143 | 178 | -35 |
| 1979-05-16 | vs LAN | 33 | W 3-2 | 11-22 | 6 | 6,277 | Eddie Solomon | Andy Messersmith | Eddie Solomon | Andy Messersmith | Gene Garber | 146 | 180 | -34 |
| 1979-05-17 | vs LAN | 34 | W 6-3 | 12-22 | 6 | 12,079 | Phil Niekro | Doug Rau | Phil Niekro | Charlie Hough | | 152 | 183 | -31 |
| 1979-05-18 | vs SFN | 35 | W 6-4 | 13-22 | 6 | 13,896 | Mickey Mahler | Vida Blue | Mickey Mahler | Vida Blue | Gene Garber | 158 | 187 | -29 |
| 1979-05-19 | vs SFN | 36 | L 2-4 | 13-24 | 6 | 0 | Tony Brizzolara | Phil Nastu | Tom Griffin | Craig Skok | Gary Lavelle | 160 | 191 | -31 |
| 1979-05-19 | vs SFN | 37 | L 6-7 | 13-24 | 6 | 24,799 | Rick Matula | Dave Roberts | John Curtis | Gene Garber | Tom Griffin | 166 | 198 | -32 |
| 1979-05-20 | vs SFN | 38 | L 1-8 | 13-25 | 6 | 10,716 | Eddie Solomon | Bob Knepper | Bob Knepper | Eddie Solomon | | 167 | 206 | -39 |
| 1979-05-21 | vs HOU | 39 | W 7-5 | 14-25 | 6 | 1,988 | Phil Niekro | Tom Dixon | Phil Niekro | Bo McLaughlin | Gene Garber | 174 | 211 | -37 |
| 1979-05-22 | vs HOU | 40 | L 1-4 | 14-26 | 6 | 5,091 | Mickey Mahler | Joe Niekro | Joe Niekro | Mickey Mahler | | 175 | 215 | -40 |
| 1979-05-23 | vs HOU | 41 | W 6-5 | 15-26 | 6 | 1,623 | Tony Brizzolara | J.R. Richard | Tony Brizzolara | Joaquin Andujar | Gene Garber | 181 | 220 | -39 |
| 1979-05-25 | @ SFN | 42 | L 4-6 | 15-27 | 6 | 11,117 | Phil Niekro | Bob Knepper | Bob Knepper | Phil Niekro | Gary Lavelle | 185 | 226 | -41 |
| 1979-05-26 | @ SFN | 43 | W 5-4 | 16-27 | 6 | 11,958 | Rick Matula | Ed Halicki | Gene Garber | Dave Roberts | Craig Skok | 190 | 230 | -40 |
| 1979-05-27 | @ SFN | 44 | W 10-8 | 17-27 | 6 | 18,936 | Eddie Solomon | Vida Blue | Craig Skok | Randy Moffitt | Gene Garber | 200 | 238 | -38 |
| 1979-05-28 | @ SFN | 45 | W 4-1 | 18-27 | 6 | 25,316 | Mickey Mahler | Phil Nastu | Mickey Mahler | Phil Nastu | | 204 | 239 | -35 |
| 1979-05-29 | @ SDN | 46 | L 3-6 | 18-29 | 6 | 0 | Tony Brizzolara | Gaylord Perry | Gaylord Perry | Tony Brizzolara | | 207 | 245 | -38 |
| 1979-05-29 | @ SDN | 47 | L 2-3 | 18-29 | 6 | 15,340 | Phil Niekro | Bob Owchinko | Bob Owchinko | Phil Niekro | Rollie Fingers | 209 | 248 | -39 |
| 1979-05-30 | @ SDN | 48 | L 2-10 | 18-30 | 6 | 12,335 | Bo McLaughlin | Mickey Lolich | Bob Shirley | Bo McLaughlin | | 211 | 258 | -47 |
| 1979-05-31 | @ SDN | 49 | L 1-3 | 18-31 | 6 | 11,143 | Rick Matula | Eric Rasmussen | Eric Rasmussen | Rick Matula | Rollie Fingers | 212 | 261 | -49 |
| 1979-06-01 | vs NYN | 50 | L 4-5 | 18-32 | 6 | 5,748 | Eddie Solomon | Kevin Kobel | Skip Lockwood | Adrian Devine | Ed Glynn | 216 | 266 | -50 |
| 1979-06-02 | vs NYN | 51 | W 7-6 | 19-32 | 6 | 25,240 | Phil Niekro | Pete Falcone | Phil Niekro | Ed Glynn | Gene Garber | 223 | 272 | -49 |
| 1979-06-03 | vs NYN | 52 | L 4-9 | 19-33 | 6 | 3,526 | Mickey Mahler | Pat Zachry | Pat Zachry | Mickey Mahler | Skip Lockwood | 227 | 281 | -54 |
| 1979-06-04 | vs MON | 53 | L 1-8 | 19-34 | 6 | 3,480 | Tony Brizzolara | Bill Lee | Bill Lee | Tony Brizzolara | | 228 | 289 | -61 |
| 1979-06-05 | vs MON | 54 | W 4-1 | 20-34 | 6 | 4,710 | Rick Matula | Scott Sanderson | Rick Matula | Scott Sanderson | Gene Garber | 232 | 290 | -58 |
| 1979-06-06 | vs MON | 55 | L 2-12 | 20-35 | 6 | 5,618 | Phil Niekro | Ross Grimsley | Ross Grimsley | Phil Niekro | | 234 | 302 | -68 |
| 1979-06-08 | @ PHI | 56 | W 11-5 | 21-35 | 6 | 41,136 | Eddie Solomon | Dick Ruthven | Gene Garber | Ron Reed | | 245 | 307 | -62 |
| 1979-06-09 | @ PHI | 57 | L 3-9 | 21-36 | 6 | 38,035 | Mickey Mahler | Larry Christenson | Larry Christenson | Mickey Mahler | | 248 | 316 | -68 |
| 1979-06-10 | @ PHI | 58 | W 10-3 | 22-36 | 6 | 58,707 | Phil Niekro | Steve Carlton | Phil Niekro | Steve Carlton | | 258 | 319 | -61 |
| 1979-06-11 | @ MON | 59 | L 5-6 | 22-37 | 6 | 10,267 | Tony Brizzolara | Ross Grimsley | Woodie Fryman | Craig Skok | | 263 | 325 | -62 |
| 1979-06-13 | @ MON | 60 | L 1-4 | 22-38 | 6 | 11,970 | Rick Matula | Steve Rogers | Steve Rogers | Rick Matula | | 264 | 329 | -65 |
| 1979-06-14 | @ MON | 61 | L 3-4 | 22-39 | 6 | 12,895 | Eddie Solomon | Bill Lee | Elias Sosa | Gene Garber | | 267 | 333 | -66 |
| 1979-06-15 | @ NYN | 62 | L 1-2 | 22-40 | 6 | 9,808 | Phil Niekro | Craig Swan | Craig Swan | Joey McLaughlin | | 268 | 335 | -67 |
| 1979-06-16 | @ NYN | 63 | L 0-2 | 22-41 | 6 | 28,313 | Mickey Mahler | Kevin Kobel | Kevin Kobel | Mickey Mahler | | 268 | 337 | -69 |
| 1979-06-17 | @ NYN | 64 | L 1-2 | 22-42 | 6 | 12,133 | Tony Brizzolara | Pete Falcone | Jeff Reardon | Gene Garber | | 269 | 339 | -70 |
| 1979-06-18 | vs PHI | 65 | W 10-5 | 23-42 | 6 | 9,394 | Rick Matula | Nino Espinosa | Rick Matula | Nino Espinosa | | 279 | 344 | -65 |
| 1979-06-19 | vs PHI | 66 | W 10-4 | 24-42 | 6 | 8,146 | Phil Niekro | Larry Christenson | Phil Niekro | Larry Christenson | | 289 | 348 | -59 |
| 1979-06-20 | vs PHI | 67 | L 4-10 | 24-43 | 6 | 8,681 | Eddie Solomon | Steve Carlton | Steve Carlton | Eddie Solomon | | 293 | 358 | -65 |
| 1979-06-21 | vs LAN | 68 | L 4-6 | 24-44 | 6 | 10,717 | Mickey Mahler | Don Sutton | Don Sutton | Mickey Mahler | Dave Patterson | 297 | 364 | -67 |
| 1979-06-22 | vs LAN | 69 | W 3-2 | 25-44 | 6 | 15,528 | Tony Brizzolara | Bob Welch | Tony Brizzolara | Bob Welch | Gene Garber | 300 | 366 | -66 |
| 1979-06-23 | vs LAN | 70 | W 7-3 | 26-44 | 6 | 16,347 | Phil Niekro | Jerry Reuss | Phil Niekro | Jerry Reuss | | 307 | 369 | -62 |
| 1979-06-24 | vs LAN | 71 | W 4-2 | 27-44 | 6 | 14,305 | Rick Matula | Burt Hooton | Rick Matula | Burt Hooton | | 311 | 371 | -60 |
| 1979-06-25 | @ SFN | 72 | W 6-1 | 28-44 | 6 | 5,813 | Eddie Solomon | John Montefusco | Eddie Solomon | John Montefusco | Craig Skok | 317 | 372 | -55 |
| 1979-06-26 | @ SFN | 73 | L 5-6 | 28-45 | 6 | 20,430 | Mickey Mahler | Vida Blue | Gary Lavelle | Gene Garber | | 322 | 378 | -56 |
| 1979-06-27 | @ SDN | 74 | L 1-2 | 29-46 | 6 | 0 | Phil Niekro | Randy Jones | Rollie Fingers | Phil Niekro | | 323 | 380 | -57 |
| 1979-06-27 | @ SDN | 75 | W 5-2 | 29-46 | 6 | 16,032 | Larry McWilliams | Bob Owchinko | Joey McLaughlin | Bob Owchinko | Gene Garber | 328 | 382 | -54 |
| 1979-06-28 | @ SDN | 76 | L 5-6 | 29-47 | 6 | 11,148 | Tony Brizzolara | Eric Rasmussen | John D'Acquisto | Tony Brizzolara | Rollie Fingers | 333 | 388 | -55 |
| 1979-06-29 | @ LAN | 77 | W 5-2 | 30-47 | 6 | 35,359 | Rick Matula | Rick Sutcliffe | Rick Matula | Rick Sutcliffe | Gene Garber | 338 | 390 | -52 |
| 1979-06-30 | @ LAN | 78 | W 7-4 | 31-47 | 6 | 38,760 | Eddie Solomon | Don Sutton | Gene Garber | Terry Forster | | 345 | 394 | -49 |
| 1979-07-01 | @ LAN | 79 | W 2-1 | 32-47 | 6 | 32,196 | Phil Niekro | Jerry Reuss | Phil Niekro | Ken Brett | Joey McLaughlin | 347 | 395 | -48 |
| 1979-07-03 | vs SFN | 80 | W 5-2 | 33-47 | 6 | 10,651 | Tony Brizzolara | Ed Halicki | Tony Brizzolara | Ed Halicki | Gene Garber | 352 | 397 | -45 |
| 1979-07-04 | vs SFN | 81 | W 7-6 | 34-47 | 5 | 47,647 | Rick Matula | Bob Knepper | Joey McLaughlin | Gary Lavelle | Gene Garber | 359 | 403 | -44 |
| 1979-07-05 | vs SFN | 82 | W 5-4 | 35-47 | 5 | 12,409 | Phil Niekro | Ed Whitson | Phil Niekro | Greg Minton | | 364 | 407 | -43 |
| 1979-07-06 | vs SLN | 83 | L 5-9 | 35-49 | 5 | 0 | Eddie Solomon | John Denny | John Denny | Eddie Solomon | | 369 | 416 | -47 |
| 1979-07-06 | vs SLN | 84 | L 4-5 | 35-49 | 5 | 24,701 | Mickey Mahler | Roy Thomas | George Frazier | Craig Skok | | 373 | 421 | -48 |
| 1979-07-07 | vs SLN | 85 | W 10-2 | 36-49 | 5 | 16,468 | Tony Brizzolara | Silvio Martinez | Tony Brizzolara | Silvio Martinez | | 383 | 423 | -40 |
| 1979-07-08 | vs SLN | 86 | W 6-5 | 37-49 | 5 | 4,160 | Rick Matula | Bob Forsch | Gene Garber | Mark Littell | | 389 | 428 | -39 |
| 1979-07-09 | vs CHN | 87 | L 4-7 | 37-50 | 5 | 3,227 | Phil Niekro | Bill Caudill | Dick Tidrow | Phil Niekro | Bruce Sutter | 393 | 435 | -42 |
| 1979-07-10 | vs CHN | 88 | L 3-7 | 37-51 | 5 | 5,687 | Eddie Solomon | Rick Reuschel | Rick Reuschel | Eddie Solomon | Bruce Sutter | 396 | 442 | -46 |
| 1979-07-11 | vs CHN | 89 | W 6-5 | 38-51 | 5 | 8,519 | Tony Brizzolara | Lynn McGlothen | Tony Brizzolara | Lynn McGlothen | Gene Garber | 402 | 447 | -45 |
| 1979-07-13 | vs PIT | 90 | W 13-4 | 39-51 | 5 | 17,018 | Phil Niekro | Jim Rooker | Phil Niekro | Jim Rooker | | 415 | 451 | -36 |
| 1979-07-14 | vs PIT | 91 | L 1-5 | 39-52 | 5 | 25,083 | Rick Matula | John Candelaria | John Candelaria | Rick Matula | | 416 | 456 | -40 |
| 1979-07-15 | vs PIT | 92 | L 3-7 | 39-53 | 5 | 11,304 | Eddie Solomon | Jim Bibby | Jim Bibby | Eddie Solomon | | 419 | 463 | -44 |
| 1979-07-19 | @ CHN | 93 | W 8-2 | 40-53 | 5 | 38,319 | Phil Niekro | Dennis Lamp | Phil Niekro | Dennis Lamp | | 427 | 465 | -38 |
| 1979-07-20 | @ CHN | 94 | L 2-10 | 40-54 | 5 | 22,646 | Tony Brizzolara | Rick Reuschel | Rick Reuschel | Tony Brizzolara | | 429 | 475 | -46 |
| 1979-07-21 | @ CHN | 95 | L 2-3 | 40-55 | 5 | 28,279 | Rick Matula | Mike Krukow | Dick Tidrow | Gene Garber | | 431 | 478 | -47 |
| 1979-07-22 | @ PIT | 96 | L 4-5 | 40-57 | 5 | 0 | Eddie Solomon | Don Robinson | Don Robinson | Eddie Solomon | Kent Tekulve | 435 | 483 | -48 |
| 1979-07-22 | @ PIT | 97 | L 2-3 | 40-57 | 5 | 29,533 | Mickey Mahler | Jim Bibby | Jim Bibby | Mickey Mahler | Kent Tekulve | 437 | 486 | -49 |
| 1979-07-23 | @ PIT | 98 | L 1-7 | 41-58 | 5 | 0 | Preston Hanna | Bert Blyleven | Bert Blyleven | Preston Hanna | | 438 | 493 | -55 |
| 1979-07-23 | @ PIT | 99 | W 8-0 | 41-58 | 5 | 27,148 | Phil Niekro | Jim Rooker | Phil Niekro | Jim Rooker | | 446 | 493 | -47 |
| 1979-07-24 | @ SLN | 100 | L 3-7 | 41-59 | 6 | 12,505 | Tony Brizzolara | Pete Vuckovich | Pete Vuckovich | Tony Brizzolara | | 449 | 500 | -51 |
| 1979-07-25 | @ SLN | 101 | W 13-4 | 42-59 | 6 | 12,590 | Rick Matula | John Denny | Joey McLaughlin | George Frazier | | 462 | 504 | -42 |
| 1979-07-26 | @ SLN | 102 | L 2-6 | 42-60 | 6 | 14,602 | Eddie Solomon | Silvio Martinez | Silvio Martinez | Eddie Solomon | | 464 | 510 | -46 |
| 1979-07-27 | vs CIN | 103 | L 0-2 | 42-61 | 6 | 21,927 | Phil Niekro | Mike LaCoss | Mike LaCoss | Phil Niekro | Doug Bair | 464 | 512 | -48 |
| 1979-07-28 | vs CIN | 104 | L 6-8 | 43-62 | 6 | 0 | Tony Brizzolara | Bill Bonham | Bill Bonham | Tony Brizzolara | Tom Hume | 470 | 520 | -50 |
| 1979-07-28 | vs CIN | 105 | W 8-5 | 43-62 | 6 | 37,265 | Mickey Mahler | Frank Pastore | Mickey Mahler | Frank Pastore | | 478 | 525 | -47 |
| 1979-07-29 | vs CIN | 106 | L 4-9 | 43-63 | 6 | 13,065 | Rick Matula | Fred Norman | Fred Norman | Rick Matula | Tom Hume | 482 | 534 | -52 |
| 1979-07-31 | vs SDN | 107 | L 3-10 | 43-64 | 6 | 9,501 | Phil Niekro | John D'Acquisto | John D'Acquisto | Phil Niekro | Mark Lee | 485 | 544 | -59 |
| 1979-08-01 | vs SDN | 108 | W 5-4 | 44-64 | 6 | 5,062 | Eddie Solomon | Randy Jones | Joey McLaughlin | Rollie Fingers | Gene Garber | 490 | 548 | -58 |
| 1979-08-02 | vs SDN | 109 | W 7-2 | 45-64 | 6 | 7,916 | Tony Brizzolara | Gaylord Perry | Tony Brizzolara | Gaylord Perry | | 497 | 550 | -53 |
| 1979-08-03 | @ HOU | 110 | L 1-4 | 45-65 | 6 | 20,716 | Rick Matula | J.R. Richard | J.R. Richard | Rick Matula | | 498 | 554 | -56 |
| 1979-08-04 | @ HOU | 111 | L 3-4 | 45-67 | 6 | 0 | Preston Hanna | Joaquin Andujar | Joe Sambito | Gene Garber | | 501 | 558 | -57 |
| 1979-08-04 | @ HOU | 112 | L 2-6 | 45-67 | 6 | 45,110 | Phil Niekro | Frank LaCorte | Frank LaCorte | Phil Niekro | Joe Sambito | 503 | 564 | -61 |
| 1979-08-05 | @ HOU | 113 | L 2-3 | 45-68 | 6 | 35,399 | Eddie Solomon | Joe Niekro | Bert Roberge | Gene Garber | Joe Sambito | 505 | 567 | -62 |
| 1979-08-06 | @ CIN | 114 | L 1-3 | 45-69 | 6 | 23,891 | Mickey Mahler | Mike LaCoss | Mike LaCoss | Mickey Mahler | | 506 | 570 | -64 |
| 1979-08-07 | @ CIN | 115 | W 3-2 | 46-69 | 6 | 25,079 | Tony Brizzolara | Tom Seaver | Gene Garber | Doug Bair | | 509 | 572 | -63 |
| 1979-08-08 | @ CIN | 116 | L 1-3 | 46-70 | 6 | 24,022 | Phil Niekro | Bill Bonham | Bill Bonham | Phil Niekro | | 510 | 575 | -65 |
| 1979-08-09 | @ CIN | 117 | L 2-5 | 46-71 | 6 | 28,950 | Rick Matula | Fred Norman | Fred Norman | Gene Garber | Tom Hume | 512 | 580 | -68 |
| 1979-08-10 | vs HOU | 118 | L 1-2 | 46-72 | 6 | 10,394 | Eddie Solomon | Joe Niekro | Joe Niekro | Eddie Solomon | Joe Sambito | 513 | 582 | -69 |
| 1979-08-12 | vs HOU | 119 | W 3-2 | 47-72 | 6 | 7,557 | Phil Niekro | Rick Williams | Phil Niekro | Rick Williams | | 516 | 584 | -68 |
| 1979-08-14 | vs NYN | 120 | L 5-18 | 47-73 | 6 | 5,770 | Tony Brizzolara | Dock Ellis | Andy Hassler | Tony Brizzolara | | 521 | 602 | -81 |
| 1979-08-15 | vs NYN | 121 | L 3-6 | 47-74 | 6 | 5,120 | Mickey Mahler | Craig Swan | Craig Swan | Mickey Mahler | Neil Allen | 524 | 608 | -84 |
| 1979-08-16 | vs NYN | 122 | L 3-6 | 47-75 | 6 | 7,397 | Phil Niekro | Pete Falcone | Pete Falcone | Phil Niekro | Neil Allen | 527 | 614 | -87 |
| 1979-08-17 | @ MON | 123 | L 0-1 | 47-76 | 6 | 31,503 | Eddie Solomon | David Palmer | David Palmer | Eddie Solomon | | 527 | 615 | -88 |
| 1979-08-18 | @ MON | 124 | L 1-2 | 47-77 | 6 | 23,115 | Preston Hanna | Steve Rogers | Steve Rogers | Joey McLaughlin | | 528 | 617 | -89 |
| 1979-08-19 | @ MON | 125 | L 1-5 | 47-78 | 6 | 34,880 | Tony Brizzolara | Bill Lee | Bill Lee | Tony Brizzolara | Stan Bahnsen | 529 | 622 | -93 |
| 1979-08-20 | @ PHI | 126 | W 5-2 | 48-78 | 6 | 35,156 | Phil Niekro | Nino Espinosa | Phil Niekro | Ron Reed | Gene Garber | 534 | 624 | -90 |
| 1979-08-21 | @ PHI | 127 | W 5-4 | 49-78 | 6 | 30,234 | Rick Matula | Randy Lerch | Larry Bradford | Rawly Eastwick | Gene Garber | 539 | 628 | -89 |
| 1979-08-22 | @ PHI | 128 | W 4-3 | 50-78 | 6 | 30,349 | Eddie Solomon | Larry Christenson | Eddie Solomon | Larry Christenson | Gene Garber | 543 | 631 | -88 |
| 1979-08-24 | vs MON | 129 | L 0-2 | 50-79 | 6 | 6,757 | Phil Niekro | Bill Lee | Bill Lee | Phil Niekro | Elias Sosa | 543 | 633 | -90 |
| 1979-08-27 | @ NYN | 130 | W 5-1 | 51-79 | 6 | 5,474 | Eddie Solomon | Kevin Kobel | Eddie Solomon | Kevin Kobel | | 548 | 634 | -86 |
| 1979-08-28 | @ NYN | 131 | W 6-4 | 52-79 | 6 | 6,586 | Phil Niekro | Dock Ellis | Phil Niekro | Dock Ellis | Joey McLaughlin | 554 | 638 | -84 |
| 1979-08-29 | @ NYN | 132 | W 5-4 | 53-79 | 6 | 6,602 | Rick Matula | Ray Burris | Rick Matula | Ray Burris | Joey McLaughlin | 559 | 642 | -83 |
| 1979-08-31 | vs PHI | 133 | L 2-6 | 53-80 | 6 | 6,009 | Tony Brizzolara | Doug Bird | Doug Bird | Tony Brizzolara | | 561 | 648 | -87 |
| 1979-09-01 | vs PHI | 134 | L 4-6 | 53-81 | 6 | 16,990 | Phil Niekro | Larry Christenson | Larry Christenson | Phil Niekro | Ron Reed | 565 | 654 | -89 |
| 1979-09-02 | vs PHI | 135 | L 1-2 | 53-82 | 6 | 10,040 | Eddie Solomon | Nino Espinosa | Ron Reed | Joey McLaughlin | | 566 | 656 | -90 |
| 1979-09-03 | vs CIN | 136 | L 5-6 | 53-83 | 6 | 3,139 | Rick Matula | Bill Bonham | Doug Bair | Gene Garber | Tom Hume | 571 | 662 | -91 |
| 1979-09-04 | vs CIN | 137 | W 7-6 | 54-83 | 6 | 2,506 | Larry McWilliams | Frank Pastore | Joey McLaughlin | Doug Bair | Larry Bradford | 578 | 668 | -90 |
| 1979-09-05 | vs LAN | 138 | L 3-5 | 54-84 | 6 | 2,606 | Phil Niekro | Rick Sutcliffe | Lerrin LaGrow | Gene Garber | Dave Patterson | 581 | 673 | -92 |
| 1979-09-06 | vs LAN | 139 | W 6-2 | 55-84 | 6 | 2,583 | Preston Hanna | Don Sutton | Preston Hanna | Don Sutton | Joey McLaughlin | 587 | 675 | -88 |
| 1979-09-07 | vs SDN | 140 | L 0-8 | 55-85 | 6 | 2,976 | Eddie Solomon | Eric Rasmussen | Eric Rasmussen | Eddie Solomon | | 587 | 683 | -96 |
| 1979-09-08 | vs SDN | 141 | L 2-9 | 55-86 | 6 | 4,261 | Rick Matula | Bob Shirley | Bob Shirley | Rick Matula | | 589 | 692 | -103 |
| 1979-09-09 | vs SDN | 142 | L 1-4 | 55-87 | 6 | 2,782 | Phil Niekro | Randy Jones | Randy Jones | Phil Niekro | Steve Mura | 590 | 696 | -106 |
| 1979-09-11 | @ SFN | 143 | W 2-1 | 56-87 | 6 | 5,128 | Larry McWilliams | John Montefusco | Larry McWilliams | John Montefusco | Joey McLaughlin | 592 | 697 | -105 |
| 1979-09-12 | @ SFN | 144 | L 3-4 | 56-88 | 6 | 1,878 | Eddie Solomon | Vida Blue | Vida Blue | Eddie Solomon | Gary Lavelle | 595 | 701 | -106 |
| 1979-09-13 | @ SFN | 145 | W 4-1 | 57-88 | 6 | 1,934 | Phil Niekro | Ed Whitson | Phil Niekro | Ed Whitson | | 599 | 702 | -103 |
| 1979-09-14 | @ SDN | 146 | W 10-7 | 58-88 | 6 | 9,116 | Tommy Boggs | Randy Jones | Mickey Mahler | Mark Lee | Gene Garber | 609 | 709 | -100 |
| 1979-09-15 | @ SDN | 147 | W 6-1 | 59-88 | 6 | 8,721 | Rick Matula | Juan Eichelberger | Rick Matula | Juan Eichelberger | Larry Bradford | 615 | 710 | -95 |
| 1979-09-17 | @ LAN | 148 | L 4-9 | 59-89 | 6 | 16,700 | Phil Niekro | Charlie Hough | Charlie Hough | Phil Niekro | | 619 | 719 | -100 |
| 1979-09-18 | @ LAN | 149 | L 1-6 | 59-90 | 6 | 21,591 | Eddie Solomon | Jerry Reuss | Jerry Reuss | Eddie Solomon | | 620 | 725 | -105 |
| 1979-09-19 | @ HOU | 150 | W 6-5 | 60-90 | 6 | 11,369 | Larry McWilliams | Vern Ruhle | Bo McLaughlin | Vern Ruhle | Gene Garber | 626 | 730 | -104 |
| 1979-09-20 | @ HOU | 151 | L 1-7 | 60-91 | 6 | 22,584 | Tommy Boggs | Ken Forsch | Ken Forsch | Tommy Boggs | | 627 | 737 | -110 |
| 1979-09-22 | vs SFN | 152 | W 10-2 | 61-91 | 6 | 7,767 | Phil Niekro | Vida Blue | Phil Niekro | Vida Blue | | 637 | 739 | -102 |
| 1979-09-23 | vs SFN | 153 | L 1-2 | 61-92 | 6 | 13,487 | Rick Matula | Ed Whitson | Greg Minton | Rick Matula | | 638 | 741 | -103 |
| 1979-09-24 | vs HOU | 154 | W 5-4 | 63-92 | 6 | 0 | Larry McWilliams | Ken Forsch | Mickey Mahler | Joe Sambito | | 643 | 745 | -102 |
| 1979-09-24 | vs HOU | 155 | W 8-1 | 63-92 | 6 | 2,321 | Eddie Solomon | Rick Williams | Eddie Solomon | Rick Williams | | 651 | 746 | -95 |
| 1979-09-25 | vs HOU | 156 | L 0-8 | 63-93 | 6 | 1,737 | Tommy Boggs | J.R. Richard | J.R. Richard | Tommy Boggs | | 651 | 754 | -103 |
| 1979-09-26 | vs HOU | 157 | W 9-4 | 64-93 | 6 | 2,248 | Phil Niekro | Joe Niekro | Phil Niekro | Joe Niekro | | 660 | 758 | -98 |
| 1979-09-28 | @ CIN | 158 | L 0-3 | 64-94 | 6 | 33,142 | Eddie Solomon | Frank Pastore | Frank Pastore | Eddie Solomon | | 660 | 761 | -101 |
| 1979-09-29 | @ CIN | 159 | W 2-0 | 65-94 | 6 | 36,466 | Larry McWilliams | Mike LaCoss | Larry McWilliams | Fred Norman | Gene Garber | 662 | 761 | -99 |
| 1979-09-30 | @ CIN | 160 | W 7-2 | 66-94 | 6 | 50,932 | Phil Niekro | Bill Bonham | Phil Niekro | Bill Bonham | | 669 | 763 | -94 |