| 1979-04-05 | vs MIL | 1 | L 1-5 | 0-1 | 6 | 52,719 | Ron Guidry | Mike Caldwell | Mike Caldwell | Ron Guidry | | 1 | 5 | -4 |
| 1979-04-07 | vs MIL | 2 | L 3-4 | 0-2 | 6 | 17,387 | Ed Figueroa | Bill Travers | Bob McClure | Ed Figueroa | Reggie Cleveland | 4 | 9 | -5 |
| 1979-04-08 | vs MIL | 3 | W 2-1 | 1-2 | 5 | 26,954 | Tommy John | Lary Sorensen | Tommy John | Lary Sorensen | Rich Gossage | 6 | 10 | -4 |
| 1979-04-10 | @ BAL | 4 | W 7-6 | 2-2 | 5 | 16,721 | Ron Guidry | Scott McGregor | Rich Gossage | Sammy Stewart | Dick Tidrow | 13 | 16 | -3 |
| 1979-04-11 | @ BAL | 5 | L 5-6 | 2-3 | 4 | 16,249 | Ed Figueroa | Jim Palmer | Don Stanhouse | Rich Gossage | | 18 | 22 | -4 |
| 1979-04-12 | @ BAL | 6 | W 5-0 | 3-3 | 4 | 18,367 | Tommy John | Mike Flanagan | Tommy John | Mike Flanagan | | 23 | 22 | 1 |
| 1979-04-13 | @ CHA | 7 | L 2-12 | 3-4 | 5 | 21,124 | Luis Tiant | Rich Wortham | Rich Wortham | Luis Tiant | | 25 | 34 | -9 |
| 1979-04-14 | @ CHA | 8 | W 8-5 | 4-4 | 4 | 43,373 | Catfish Hunter | Ken Kravec | Dick Tidrow | Dewey Robinson | Ron Guidry | 33 | 39 | -6 |
| 1979-04-15 | @ CHA | 9 | W 6-5 | 5-4 | 3 | 18,681 | Ed Figueroa | Ross Baumgarten | Ed Figueroa | Mike Proly | Rich Gossage | 39 | 44 | -5 |
| 1979-04-17 | vs BAL | 10 | W 5-1 | 6-4 | 3 | 20,135 | Ron Guidry | Mike Flanagan | Ron Guidry | Mike Flanagan | | 44 | 45 | -1 |
| 1979-04-18 | vs BAL | 11 | W 3-1 | 7-4 | 2 | 25,562 | Tommy John | Dennis Martinez | Tommy John | Dennis Martinez | Rich Gossage | 47 | 46 | 1 |
| 1979-04-19 | vs BAL | 12 | L 3-6 | 7-5 | 3 | 21,201 | Luis Tiant | Jim Palmer | Jim Palmer | Paul Mirabella | | 50 | 52 | -2 |
| 1979-04-20 | vs TEX | 13 | W 5-3 | 8-5 | 2 | 26,651 | Ed Figueroa | Steve Comer | Ed Figueroa | Steve Comer | Dick Tidrow | 55 | 55 | 0 |
| 1979-04-21 | vs TEX | 14 | L 0-5 | 8-6 | 2 | 25,530 | Catfish Hunter | Fergie Jenkins | Fergie Jenkins | Catfish Hunter | | 55 | 60 | -5 |
| 1979-04-22 | vs TEX | 15 | W 5-1 | 9-6 | 2 | 35,250 | Ron Guidry | Dock Ellis | Ron Guidry | Dock Ellis | | 60 | 61 | -1 |
| 1979-04-24 | @ OAK | 16 | W 3-1 | 10-6 | 2 | 9,158 | Tommy John | John Henry Johnson | Tommy John | John Henry Johnson | | 63 | 62 | 1 |
| 1979-04-25 | @ OAK | 17 | L 0-1 | 10-7 | 2 | 7,135 | Ed Figueroa | Craig Minetto | Craig Minetto | Ed Figueroa | Jim Todd | 63 | 63 | 0 |
| 1979-04-27 | @ SEA | 18 | L 5-6 | 10-8 | 4 | 24,658 | Ron Guidry | Rick Honeycutt | Mike Parrott | Dick Tidrow | Shane Rawley | 68 | 69 | -1 |
| 1979-04-28 | @ SEA | 19 | L 2-3 | 10-9 | 4 | 35,048 | Catfish Hunter | Glenn Abbott | Shane Rawley | Catfish Hunter | John Montague | 70 | 72 | -2 |
| 1979-04-29 | @ SEA | 20 | L 5-6 | 10-10 | 4 | 29,041 | Tommy John | Odell Jones | Rafael Vasquez | Paul Mirabella | | 75 | 78 | -3 |
| 1979-04-30 | @ CAL | 21 | L 1-2 | 10-11 | 4 | 37,180 | Ed Figueroa | Jim Barr | Dave LaRoche | Ed Figueroa | | 76 | 80 | -4 |
| 1979-05-01 | @ CAL | 22 | W 12-8 | 11-11 | 4 | 38,858 | Luis Tiant | Frank Tanana | Tommy John | Dave LaRoche | | 88 | 88 | 0 |
| 1979-05-02 | @ CAL | 23 | L 0-1 | 11-12 | 4 | 40,648 | Ron Guidry | Nolan Ryan | Nolan Ryan | Ron Guidry | | 88 | 89 | -1 |
| 1979-05-04 | vs OAK | 24 | L 5-11 | 11-13 | 4 | 17,705 | Ed Figueroa | Mike Norris | Mike Norris | Jim Beattie | Bob Lacey | 93 | 100 | -7 |
| 1979-05-05 | vs OAK | 25 | W 5-4 | 12-13 | 4 | 30,167 | Tommy John | John Henry Johnson | Tommy John | Dave Heaverlo | | 98 | 104 | -6 |
| 1979-05-06 | vs OAK | 26 | W 6-5 | 13-13 | 4 | 46,750 | Catfish Hunter | Craig Minetto | Ron Guidry | Dave Heaverlo | | 104 | 109 | -5 |
| 1979-05-07 | vs SEA | 27 | L 4-12 | 13-14 | 4 | 14,065 | Luis Tiant | Byron McLaughlin | Rick Honeycutt | Paul Mirabella | | 108 | 121 | -13 |
| 1979-05-08 | vs SEA | 28 | W 5-3 | 14-14 | 4 | 15,981 | Jim Beattie | Floyd Bannister | Jim Beattie | Floyd Bannister | Ron Guidry | 113 | 124 | -11 |
| 1979-05-09 | vs SEA | 29 | W 5-0 | 15-14 | 4 | 14,738 | Ed Figueroa | Glenn Abbott | Ed Figueroa | Glenn Abbott | | 118 | 124 | -6 |
| 1979-05-10 | vs SEA | 30 | W 8-1 | 16-14 | 4 | 14,394 | Tommy John | Odell Jones | Tommy John | Odell Jones | | 126 | 125 | 1 |
| 1979-05-11 | vs CAL | 31 | L 1-4 | 16-15 | 4 | 37,988 | Catfish Hunter | Jim Barr | Jim Barr | Catfish Hunter | | 127 | 129 | -2 |
| 1979-05-12 | vs CAL | 32 | W 6-5 | 17-15 | 4 | 28,783 | Luis Tiant | Dyar Miller | Dick Tidrow | Dave Frost | | 133 | 134 | -1 |
| 1979-05-13 | vs CAL | 33 | W 12-10 | 18-15 | 4 | 30,083 | Jim Beattie | Chris Knapp | Jim Beattie | Chris Knapp | | 145 | 144 | 1 |
| 1979-05-14 | vs DET | 34 | L 1-3 | 18-16 | 4 | 15,650 | Ed Figueroa | Milt Wilcox | Milt Wilcox | Ed Figueroa | | 146 | 147 | -1 |
| 1979-05-15 | vs DET | 35 | W 11-3 | 19-16 | 4 | 18,876 | Tommy John | Steve Baker | Tommy John | Steve Baker | | 157 | 150 | 7 |
| 1979-05-16 | vs DET | 36 | W 6-2 | 20-16 | 4 | 43,843 | Ron Guidry | Mark Fidrych | Ron Guidry | Mark Fidrych | | 163 | 152 | 11 |
| 1979-05-18 | @ BOS | 37 | W 10-0 | 21-16 | 3 | 33,694 | Jim Beattie | Mike Torrez | Jim Beattie | Mike Torrez | | 173 | 152 | 21 |
| 1979-05-19 | @ BOS | 38 | L 3-4 | 21-17 | 3 | 33,224 | Ed Figueroa | Chuck Rainey | Bill Campbell | Ed Figueroa | Dick Drago | 176 | 156 | 20 |
| 1979-05-20 | @ BOS | 39 | W 2-0 | 22-17 | 3 | 33,932 | Tommy John | Dennis Eckersley | Tommy John | Dennis Eckersley | | 178 | 156 | 22 |
| 1979-05-21 | @ DET | 40 | L 1-3 | 22-18 | 3 | 26,153 | Ron Guidry | Jack Billingham | Jack Billingham | Ron Guidry | | 179 | 159 | 20 |
| 1979-05-22 | @ DET | 41 | W 12-8 | 23-18 | 3 | 33,497 | Luis Tiant | Mark Fidrych | Luis Tiant | Mark Fidrych | | 191 | 167 | 24 |
| 1979-05-23 | @ DET | 42 | L 3-4 | 23-19 | 3 | 21,671 | Jim Beattie | Jack Morris | John Hiller | Ken Clay | | 194 | 171 | 23 |
| 1979-05-26 | @ CLE | 43 | L 4-8 | 23-20 | 4 | 27,710 | Tommy John | Rick Waits | Rick Waits | Tommy John | | 198 | 179 | 19 |
| 1979-05-27 | @ CLE | 44 | L 0-5 | 24-21 | 4 | 0 | Ron Guidry | Rick Wise | Rick Wise | Ron Guidry | | 198 | 184 | 14 |
| 1979-05-27 | @ CLE | 45 | W 5-4 | 24-21 | 4 | 40,648 | Luis Tiant | Mike Paxton | Ray Burris | Sid Monge | | 203 | 188 | 15 |
| 1979-05-28 | @ MIL | 46 | W 2-1 | 25-21 | 3 | 39,291 | Jim Beattie | Bill Travers | Ron Davis | Bill Travers | | 205 | 189 | 16 |
| 1979-05-29 | @ MIL | 47 | L 3-7 | 25-22 | 4 | 21,891 | Catfish Hunter | Moose Haas | Moose Haas | Catfish Hunter | | 208 | 196 | 12 |
| 1979-05-30 | @ MIL | 48 | W 5-2 | 26-22 | 3 | 27,338 | Tommy John | Mike Caldwell | Ron Davis | Bob McClure | | 213 | 198 | 15 |
| 1979-05-31 | @ MIL | 49 | L 4-5 | 26-23 | 4 | 24,707 | Luis Tiant | Jim Slaton | Jerry Augustine | Ray Burris | | 217 | 203 | 14 |
| 1979-06-01 | vs CHA | 50 | W 4-0 | 27-23 | 4 | 33,230 | Ron Guidry | Francisco Barrios | Ron Guidry | Francisco Barrios | | 221 | 203 | 18 |
| 1979-06-02 | vs CHA | 51 | L 0-7 | 27-24 | 4 | 53,539 | Jim Beattie | Ken Kravec | Ken Kravec | Jim Beattie | | 221 | 210 | 11 |
| 1979-06-03 | vs CHA | 52 | W 3-2 | 28-24 | 3 | 55,073 | Catfish Hunter | Rich Wortham | Ron Davis | Randy Scarbery | | 224 | 212 | 12 |
| 1979-06-04 | vs KCA | 53 | W 8-3 | 29-24 | 3 | 30,164 | Tommy John | Rich Gale | Tommy John | Rich Gale | | 232 | 215 | 17 |
| 1979-06-05 | vs KCA | 54 | L 1-3 | 29-25 | 4 | 24,968 | Luis Tiant | Larry Gura | Larry Gura | Luis Tiant | | 233 | 218 | 15 |
| 1979-06-06 | vs MIN | 55 | W 3-2 | 30-25 | 4 | 34,075 | Ron Guidry | Jerry Koosman | Ron Guidry | Jerry Koosman | | 236 | 220 | 16 |
| 1979-06-07 | vs MIN | 56 | L 1-4 | 30-26 | 4 | 20,722 | Jim Beattie | Geoff Zahn | Geoff Zahn | Jim Beattie | Mike Marshall | 237 | 224 | 13 |
| 1979-06-08 | @ KCA | 57 | W 11-10 | 31-26 | 4 | 35,589 | Ed Figueroa | Rich Gale | Ken Clay | Eduardo Rodriguez | | 248 | 234 | 14 |
| 1979-06-09 | @ KCA | 58 | L 8-9 | 31-27 | 4 | 38,025 | Tommy John | Larry Gura | Marty Pattin | Ken Clay | | 256 | 243 | 13 |
| 1979-06-10 | @ KCA | 59 | W 10-4 | 32-27 | 3 | 41,095 | Luis Tiant | Steve Mingori | Luis Tiant | Steve Mingori | | 266 | 247 | 19 |
| 1979-06-12 | @ MIN | 60 | W 4-1 | 33-27 | 3 | 27,733 | Ron Guidry | Jerry Koosman | Ron Davis | Jerry Koosman | | 270 | 248 | 22 |
| 1979-06-13 | @ MIN | 61 | L 7-8 | 33-28 | 3 | 19,660 | Jim Beattie | Dave Goltz | Pete Redfern | Ray Burris | Mike Marshall | 277 | 256 | 21 |
| 1979-06-14 | @ MIN | 62 | L 2-4 | 33-29 | 4 | 24,129 | Tommy John | Geoff Zahn | Geoff Zahn | Tommy John | Mike Marshall | 279 | 260 | 19 |
| 1979-06-15 | @ TEX | 63 | L 5-9 | 33-30 | 4 | 35,452 | Ed Figueroa | Jon Matlack | Jon Matlack | Ed Figueroa | | 284 | 269 | 15 |
| 1979-06-16 | @ TEX | 64 | W 3-2 | 34-30 | 4 | 41,097 | Luis Tiant | Dave Rajsich | Ron Davis | Sparky Lyle | | 287 | 271 | 16 |
| 1979-06-17 | @ TEX | 65 | L 3-6 | 34-31 | 4 | 37,405 | Catfish Hunter | Steve Comer | Steve Comer | Catfish Hunter | | 290 | 277 | 13 |
| 1979-06-19 | vs TOR | 66 | L 4-5 | 34-32 | 4 | 36,211 | Tommy John | Phil Huffman | Phil Huffman | Tommy John | Tom Buskey | 294 | 282 | 12 |
| 1979-06-20 | vs TOR | 67 | W 2-1 | 35-33 | 4 | 0 | Jim Beattie | Tom Underwood | Don Hood | Tom Underwood | Ron Davis | 296 | 283 | 13 |
| 1979-06-20 | vs TOR | 68 | L 2-3 | 35-33 | 4 | 32,129 | Ed Figueroa | Balor Moore | Balor Moore | Ray Burris | | 298 | 286 | 12 |
| 1979-06-21 | vs TOR | 69 | W 3-1 | 36-33 | 4 | 19,278 | Luis Tiant | Dave Lemanczyk | Luis Tiant | Dave Lemanczyk | Ron Davis | 301 | 287 | 14 |
| 1979-06-22 | vs CLE | 70 | W 3-2 | 37-33 | 4 | 33,776 | Catfish Hunter | Eric Wilkins | Catfish Hunter | Eric Wilkins | Ken Clay | 304 | 289 | 15 |
| 1979-06-23 | vs CLE | 71 | W 6-5 | 38-33 | 4 | 35,818 | Tommy John | Rick Wise | Tommy John | Victor Cruz | | 310 | 294 | 16 |
| 1979-06-24 | vs CLE | 72 | W 8-2 | 39-33 | 4 | 55,409 | Ed Figueroa | Rick Waits | Jim Kaat | Rick Waits | Ron Davis | 318 | 296 | 22 |
| 1979-06-25 | @ TOR | 73 | L 1-3 | 39-34 | 4 | 37,612 | Ken Clay | Tom Underwood | Tom Underwood | Ken Clay | | 319 | 299 | 20 |
| 1979-06-26 | @ TOR | 74 | W 11-2 | 40-34 | 4 | 38,696 | Luis Tiant | Dave Lemanczyk | Luis Tiant | Dave Lemanczyk | | 330 | 301 | 29 |
| 1979-06-28 | @ TOR | 75 | W 5-3 | 41-34 | 4 | 39,347 | Tommy John | Balor Moore | Ron Davis | Mark Lemongello | | 335 | 304 | 31 |
| 1979-06-29 | vs BOS | 76 | L 2-3 | 41-35 | 4 | 53,306 | Ron Guidry | Mike Torrez | Dick Drago | Jim Kaat | | 337 | 307 | 30 |
| 1979-06-30 | vs BOS | 77 | L 2-3 | 41-36 | 4 | 50,253 | Luis Tiant | Bob Stanley | Bob Stanley | Luis Tiant | | 339 | 310 | 29 |
| 1979-07-01 | vs BOS | 78 | W 6-5 | 42-36 | 4 | 51,246 | Catfish Hunter | Dennis Eckersley | Ron Davis | Dennis Eckersley | Jim Kaat | 345 | 315 | 30 |
| 1979-07-02 | vs BOS | 79 | W 7-2 | 43-36 | 4 | 51,211 | Tommy John | Joel Finch | Tommy John | Joel Finch | | 352 | 317 | 35 |
| 1979-07-03 | vs MIL | 80 | L 2-7 | 43-37 | 4 | 35,158 | Ken Clay | Mike Caldwell | Mike Caldwell | Ken Clay | | 354 | 324 | 30 |
| 1979-07-04 | vs MIL | 81 | W 4-3 | 44-37 | 4 | 20,084 | Luis Tiant | Bill Travers | Luis Tiant | Bill Travers | Ron Davis | 358 | 327 | 31 |
| 1979-07-05 | vs MIL | 82 | L 0-3 | 44-38 | 4 | 31,878 | Ron Guidry | Lary Sorensen | Lary Sorensen | Ron Guidry | | 358 | 330 | 28 |
| 1979-07-06 | @ OAK | 83 | W 4-3 | 46-38 | 4 | 0 | Catfish Hunter | Steve McCatty | Ron Davis | Steve McCatty | | 362 | 333 | 29 |
| 1979-07-06 | @ OAK | 84 | W 3-0 | 46-38 | 4 | 19,538 | Tommy John | Dave Hamilton | Tommy John | Dave Hamilton | | 365 | 333 | 32 |
| 1979-07-07 | @ OAK | 85 | W 8-3 | 47-38 | 4 | 10,413 | Don Hood | Mike Morgan | Don Hood | Mike Morgan | Ken Clay | 373 | 336 | 37 |
| 1979-07-08 | @ OAK | 86 | W 2-0 | 48-38 | 4 | 13,483 | Luis Tiant | Brian Kingman | Luis Tiant | Brian Kingman | | 375 | 336 | 39 |
| 1979-07-10 | @ SEA | 87 | L 1-5 | 48-39 | 4 | 20,375 | Ron Guidry | Rick Honeycutt | Rick Honeycutt | Ron Guidry | | 376 | 341 | 35 |
| 1979-07-11 | @ SEA | 88 | L 1-16 | 48-40 | 4 | 31,186 | Tommy John | Floyd Bannister | Floyd Bannister | Tommy John | | 377 | 357 | 20 |
| 1979-07-12 | @ SEA | 89 | W 14-2 | 49-40 | 4 | 23,774 | Catfish Hunter | Mike Parrott | Catfish Hunter | Mike Parrott | | 391 | 359 | 32 |
| 1979-07-13 | @ CAL | 90 | L 1-6 | 49-41 | 4 | 41,805 | Luis Tiant | Nolan Ryan | Nolan Ryan | Luis Tiant | | 392 | 365 | 27 |
| 1979-07-14 | @ CAL | 91 | L 7-8 | 49-42 | 4 | 41,693 | Tommy John | Don Aase | Mark Clear | Ron Davis | | 399 | 373 | 26 |
| 1979-07-15 | @ CAL | 92 | L 4-5 | 49-43 | 4 | 40,739 | Ron Guidry | Dave Frost | Jim Barr | Ron Guidry | | 403 | 378 | 25 |
| 1979-07-19 | vs OAK | 93 | W 10-2 | 50-43 | 4 | 22,648 | Luis Tiant | Mike Morgan | Luis Tiant | Mike Morgan | | 413 | 380 | 33 |
| 1979-07-20 | vs OAK | 94 | L 1-5 | 50-44 | 4 | 30,481 | Tommy John | Brian Kingman | Brian Kingman | Tommy John | Dave Hamilton | 414 | 385 | 29 |
| 1979-07-21 | vs OAK | 95 | W 12-4 | 51-44 | 4 | 49,284 | Ron Guidry | Craig Minetto | Ron Guidry | Craig Minetto | | 426 | 389 | 37 |
| 1979-07-22 | vs SEA | 96 | W 4-0 | 52-44 | 4 | 38,956 | Don Hood | Rick Honeycutt | Jim Kaat | Rick Honeycutt | | 430 | 389 | 41 |
| 1979-07-23 | vs SEA | 97 | W 6-2 | 53-44 | 4 | 20,674 | Ed Figueroa | Glenn Abbott | Ed Figueroa | Glenn Abbott | Rich Gossage | 436 | 391 | 45 |
| 1979-07-24 | vs CAL | 98 | W 6-5 | 54-44 | 4 | 33,497 | Luis Tiant | Don Aase | Ron Davis | Dave LaRoche | Rich Gossage | 442 | 396 | 46 |
| 1979-07-25 | vs CAL | 99 | L 5-9 | 54-45 | 4 | 47,449 | Tommy John | Nolan Ryan | Ralph Botting | Tommy John | Mark Clear | 447 | 405 | 42 |
| 1979-07-26 | vs CAL | 100 | W 2-0 | 55-45 | 4 | 43,136 | Ron Guidry | Jim Barr | Ron Guidry | Jim Barr | | 449 | 405 | 44 |
| 1979-07-27 | @ MIL | 101 | L 5-6 | 55-46 | 4 | 47,928 | Ed Figueroa | Mike Caldwell | Bob McClure | Rich Gossage | | 454 | 411 | 43 |
| 1979-07-28 | @ MIL | 102 | L 2-9 | 55-47 | 4 | 51,952 | Luis Tiant | Lary Sorensen | Lary Sorensen | Luis Tiant | | 456 | 420 | 36 |
| 1979-07-29 | @ MIL | 103 | L 3-5 | 55-48 | 4 | 49,842 | Catfish Hunter | Bill Travers | Bill Travers | Catfish Hunter | Bob McClure | 459 | 425 | 34 |
| 1979-07-30 | @ CHA | 104 | W 7-2 | 56-48 | 4 | 22,486 | Tommy John | Rich Wortham | Tommy John | Rich Wortham | Ron Davis | 466 | 427 | 39 |
| 1979-07-31 | @ CHA | 105 | W 7-3 | 57-48 | 4 | 24,972 | Ron Guidry | Randy Scarbery | Ron Guidry | Randy Scarbery | Rich Gossage | 473 | 430 | 43 |
| 1979-08-01 | @ CHA | 106 | W 9-1 | 58-48 | 4 | 21,109 | Don Hood | Ken Kravec | Don Hood | Ken Kravec | | 482 | 431 | 51 |
| 1979-08-03 | vs BAL | 107 | L 0-1 | 58-49 | 4 | 51,151 | Luis Tiant | Scott McGregor | Scott McGregor | Luis Tiant | Tippy Martinez | 482 | 432 | 50 |
| 1979-08-04 | vs BAL | 108 | L 4-5 | 58-50 | 4 | 46,407 | Catfish Hunter | Steve Stone | Dave Ford | Jim Kaat | Tippy Martinez | 486 | 437 | 49 |
| 1979-08-05 | vs BAL | 109 | W 3-2 | 59-50 | 4 | 54,478 | Tommy John | Mike Flanagan | Tommy John | Mike Flanagan | | 489 | 439 | 50 |
| 1979-08-06 | vs BAL | 110 | W 5-4 | 60-50 | 4 | 36,314 | Ron Guidry | Dennis Martinez | Ron Guidry | Tippy Martinez | | 494 | 443 | 51 |
| 1979-08-07 | vs CHA | 111 | L 5-9 | 60-51 | 4 | 33,513 | Don Hood | Ross Baumgarten | Randy Scarbery | Ken Clay | Ed Farmer | 499 | 452 | 47 |
| 1979-08-08 | vs CHA | 112 | W 4-3 | 61-51 | 4 | 20,048 | Luis Tiant | Steve Trout | Luis Tiant | Steve Trout | Ron Davis | 503 | 455 | 48 |
| 1979-08-09 | vs CHA | 113 | L 1-5 | 61-52 | 4 | 21,535 | Catfish Hunter | Rich Wortham | Rich Wortham | Catfish Hunter | | 504 | 460 | 44 |
| 1979-08-10 | @ BAL | 114 | L 6-8 | 61-53 | 4 | 44,646 | Tommy John | Dennis Martinez | Tippy Martinez | Ron Davis | | 510 | 468 | 42 |
| 1979-08-13 | vs TEX | 115 | W 3-2 | 62-53 | 4 | 24,977 | Ron Guidry | Fergie Jenkins | Ron Guidry | Fergie Jenkins | | 513 | 470 | 43 |
| 1979-08-14 | vs TEX | 116 | W 6-5 | 63-53 | 4 | 24,125 | Luis Tiant | Doc Medich | Luis Tiant | Jim Kern | Rich Gossage | 519 | 475 | 44 |
| 1979-08-15 | vs TEX | 117 | W 4-3 | 64-53 | 4 | 25,905 | Tommy John | Jerry Gleaton | Tommy John | Jerry Gleaton | Rich Gossage | 523 | 478 | 45 |
| 1979-08-16 | vs MIN | 118 | L 1-5 | 64-54 | 4 | 22,036 | Catfish Hunter | Geoff Zahn | Geoff Zahn | Catfish Hunter | | 524 | 483 | 41 |
| 1979-08-17 | vs MIN | 119 | L 2-5 | 64-55 | 4 | 30,372 | Jim Beattie | Jerry Koosman | Jerry Koosman | Jim Beattie | | 526 | 488 | 38 |
| 1979-08-18 | vs MIN | 120 | W 5-3 | 65-55 | 4 | 38,695 | Jim Kaat | Mike Marshall | Ron Davis | Mike Marshall | Rich Gossage | 531 | 491 | 40 |
| 1979-08-19 | vs MIN | 121 | W 4-3 | 66-55 | 4 | 47,723 | Ron Guidry | Darrell Jackson | Ron Guidry | Darrell Jackson | Rich Gossage | 535 | 494 | 41 |
| 1979-08-20 | @ KCA | 122 | W 17-4 | 67-55 | 4 | 41,305 | Luis Tiant | Rich Gale | Luis Tiant | Rich Gale | Don Hood | 552 | 498 | 54 |
| 1979-08-21 | @ KCA | 123 | W 6-2 | 68-55 | 4 | 38,514 | Tommy John | Paul Splittorff | Rich Gossage | Paul Splittorff | | 558 | 500 | 58 |
| 1979-08-22 | @ KCA | 124 | L 1-3 | 68-56 | 4 | 34,400 | Jim Beattie | Larry Gura | Larry Gura | Jim Beattie | | 559 | 503 | 56 |
| 1979-08-24 | @ MIN | 125 | W 7-5 | 69-56 | 4 | 29,800 | Ron Guidry | Geoff Zahn | Ron Guidry | Geoff Zahn | Rich Gossage | 566 | 508 | 58 |
| 1979-08-25 | @ MIN | 126 | L 1-4 | 69-57 | 4 | 36,363 | Luis Tiant | Jerry Koosman | Jerry Koosman | Luis Tiant | Mike Marshall | 567 | 512 | 55 |
| 1979-08-27 | @ TEX | 127 | W 7-4 | 70-57 | 4 | 24,922 | Tommy John | Fergie Jenkins | Tommy John | Fergie Jenkins | Ron Davis | 574 | 516 | 58 |
| 1979-08-28 | @ TEX | 128 | L 2-10 | 70-58 | 4 | 23,339 | Ken Clay | John Henry Johnson | Jim Kern | Ken Clay | | 576 | 526 | 50 |
| 1979-08-29 | @ TEX | 129 | W 7-5 | 71-58 | 4 | 18,117 | Ron Guidry | Dave Rajsich | Ron Guidry | Dave Rajsich | Rich Gossage | 583 | 531 | 52 |
| 1979-08-30 | vs KCA | 130 | L 3-8 | 71-59 | 4 | 30,717 | Luis Tiant | Larry Gura | Larry Gura | Luis Tiant | | 586 | 539 | 47 |
| 1979-08-31 | vs KCA | 131 | W 7-3 | 72-59 | 4 | 35,229 | Tommy John | Paul Splittorff | Tommy John | Paul Splittorff | | 593 | 542 | 51 |
| 1979-09-01 | vs KCA | 132 | L 8-9 | 72-60 | 4 | 30,130 | Ken Clay | Rich Gale | Al Hrabosky | Jim Kaat | Renie Martin | 601 | 551 | 50 |
| 1979-09-02 | vs KCA | 133 | W 6-5 | 73-60 | 4 | 34,008 | Catfish Hunter | Craig Chamberlain | Rich Gossage | Steve Mingori | | 607 | 556 | 51 |
| 1979-09-03 | vs BOS | 134 | W 10-6 | 74-60 | 4 | 46,298 | Ron Guidry | Dennis Eckersley | Ron Guidry | Dennis Eckersley | Ron Davis | 617 | 562 | 55 |
| 1979-09-04 | vs BOS | 135 | W 3-2 | 75-60 | 4 | 37,259 | Luis Tiant | Mike Torrez | Luis Tiant | Mike Torrez | Rich Gossage | 620 | 564 | 56 |
| 1979-09-05 | vs BOS | 136 | L 0-5 | 75-61 | 4 | 38,644 | Tommy John | Bob Stanley | Bob Stanley | Tommy John | | 620 | 569 | 51 |
| 1979-09-06 | @ DET | 137 | W 3-1 | 76-61 | 4 | 19,196 | Don Hood | Milt Wilcox | Rich Gossage | Milt Wilcox | | 623 | 570 | 53 |
| 1979-09-07 | @ DET | 138 | L 0-6 | 76-62 | 4 | 28,943 | Ken Clay | Bruce Robbins | Jack Billingham | Ken Clay | | 623 | 576 | 47 |
| 1979-09-08 | @ DET | 139 | W 5-4 | 77-62 | 4 | 30,069 | Ron Guidry | Jack Morris | Ron Guidry | Jack Morris | Rich Gossage | 628 | 580 | 48 |
| 1979-09-09 | @ DET | 140 | L 1-3 | 77-63 | 4 | 30,836 | Tommy John | Mike Chris | Mike Chris | Tommy John | Aurelio Lopez | 629 | 583 | 46 |
| 1979-09-11 | @ BOS | 141 | W 8-3 | 78-63 | 4 | 35,689 | Luis Tiant | John Tudor | Ron Davis | Tom Burgmeier | Rich Gossage | 637 | 586 | 51 |
| 1979-09-12 | @ BOS | 142 | L 2-9 | 78-64 | 4 | 34,336 | Catfish Hunter | Chuck Rainey | Chuck Rainey | Catfish Hunter | | 639 | 595 | 44 |
| 1979-09-13 | @ BOS | 143 | W 10-3 | 79-64 | 4 | 32,474 | Ron Guidry | Mike Torrez | Ron Guidry | Mike Torrez | | 649 | 598 | 51 |
| 1979-09-15 | vs DET | 144 | L 3-4 | 80-65 | 4 | 0 | Tommy John | Jack Morris | Jack Morris | Tommy John | Aurelio Lopez | 652 | 602 | 50 |
| 1979-09-15 | vs DET | 145 | W 7-1 | 80-65 | 4 | 30,050 | Don Hood | Mike Chris | Ron Davis | Mike Chris | Jim Kaat | 659 | 603 | 56 |
| 1979-09-16 | vs DET | 146 | L 4-8 | 80-66 | 4 | 40,192 | Dave Righetti | Dave Rozema | Aurelio Lopez | Rich Gossage | | 663 | 611 | 52 |
| 1979-09-17 | @ CLE | 147 | L 1-5 | 80-68 | 4 | 0 | Jim Beattie | Rick Waits | Rick Waits | Jim Beattie | | 664 | 616 | 48 |
| 1979-09-17 | @ CLE | 148 | L 5-6 | 80-68 | 4 | 14,063 | Catfish Hunter | Dan Spillner | Sid Monge | Don Hood | | 669 | 622 | 47 |
| 1979-09-18 | @ CLE | 149 | L 3-16 | 80-69 | 4 | 8,908 | Paul Mirabella | Mike Paxton | Mike Paxton | Paul Mirabella | | 672 | 638 | 34 |
| 1979-09-19 | @ CLE | 150 | W 2-0 | 81-69 | 4 | 8,216 | Tommy John | Rick Wise | Tommy John | Rick Wise | Ron Davis | 674 | 638 | 36 |
| 1979-09-20 | @ MIN | 151 | L 1-3 | 81-70 | 4 | 5,357 | Dave Righetti | Geoff Zahn | Geoff Zahn | Dave Righetti | | 675 | 641 | 34 |
| 1979-09-21 | @ TOR | 152 | L 2-3 | 81-71 | 4 | 22,331 | Ron Guidry | Tom Underwood | Tom Underwood | Ron Guidry | Tom Buskey | 677 | 644 | 33 |
| 1979-09-22 | @ TOR | 153 | W 7-4 | 82-71 | 4 | 37,408 | Luis Tiant | Butch Edge | Luis Tiant | Butch Edge | Rich Gossage | 684 | 648 | 36 |
| 1979-09-23 | @ TOR | 154 | W 7-5 | 83-71 | 4 | 28,137 | Tommy John | Phil Huffman | Tommy John | Phil Huffman | Rich Gossage | 691 | 653 | 38 |
| 1979-09-25 | vs CLE | 155 | W 7-5 | 84-71 | 4 | 15,699 | Jim Beattie | Rick Wise | Ron Davis | Rick Wise | Rich Gossage | 698 | 658 | 40 |
| 1979-09-26 | vs CLE | 156 | W 6-3 | 85-71 | 4 | 16,354 | Ron Guidry | Mike Paxton | Ron Guidry | Mike Paxton | | 704 | 661 | 43 |
| 1979-09-27 | vs CLE | 157 | W 5-2 | 86-71 | 4 | 12,111 | Dave Righetti | Rick Waits | Rich Gossage | Sid Monge | | 709 | 663 | 46 |
| 1979-09-28 | vs TOR | 158 | W 7-3 | 87-71 | 4 | 17,647 | Luis Tiant | Butch Edge | Luis Tiant | Butch Edge | | 716 | 666 | 50 |
| 1979-09-29 | vs TOR | 159 | W 9-4 | 88-71 | 4 | 30,016 | Tommy John | Phil Huffman | Tommy John | Phil Huffman | | 725 | 670 | 55 |
| 1979-09-30 | vs TOR | 160 | W 9-2 | 89-71 | 4 | 28,150 | Ron Guidry | Dave Stieb | Ron Davis | Dave Stieb | Mike Griffin | 734 | 672 | 62 |