| 1979-04-06 | @ OAK | 1 | W 5-3 | 1-0 | 2 | 10,387 | Dave Goltz | Rick Langford | Dave Goltz | Rick Langford | Mike Marshall | 5 | 3 | 2 |
| 1979-04-07 | @ OAK | 2 | W 3-1 | 2-0 | 2 | 3,222 | Roger Erickson | Matt Keough | Mike Marshall | Jim Todd | | 8 | 4 | 4 |
| 1979-04-08 | @ OAK | 3 | W 3-1 | 3-0 | 2 | 3,326 | Geoff Zahn | Mike Norris | Geoff Zahn | Mike Norris | | 11 | 5 | 6 |
| 1979-04-10 | @ CAL | 4 | W 8-1 | 4-0 | 1 | 33,171 | Jerry Koosman | Frank Tanana | Jerry Koosman | Frank Tanana | Mike Marshall | 19 | 6 | 13 |
| 1979-04-11 | @ CAL | 5 | L 2-11 | 4-1 | 3 | 21,633 | Dave Goltz | Nolan Ryan | Nolan Ryan | Dave Goltz | | 21 | 17 | 4 |
| 1979-04-12 | @ CAL | 6 | L 1-7 | 4-2 | 3 | 22,211 | Roger Erickson | Chris Knapp | Chris Knapp | Roger Erickson | | 22 | 24 | -2 |
| 1979-04-13 | @ SEA | 7 | W 8-2 | 5-2 | 2 | 8,125 | Geoff Zahn | Paul Mitchell | Geoff Zahn | Paul Mitchell | Mike Marshall | 30 | 26 | 4 |
| 1979-04-14 | @ SEA | 8 | W 6-5 | 6-2 | 2 | 17,070 | Paul Hartzell | Floyd Bannister | Mike Marshall | Floyd Bannister | | 36 | 31 | 5 |
| 1979-04-15 | @ SEA | 9 | W 18-6 | 7-2 | 2 | 5,966 | Jerry Koosman | Glenn Abbott | Jerry Koosman | Glenn Abbott | | 54 | 37 | 17 |
| 1979-04-17 | vs CAL | 10 | L 0-6 | 7-3 | 3 | 37,529 | Dave Goltz | Nolan Ryan | Nolan Ryan | Dave Goltz | | 54 | 43 | 11 |
| 1979-04-18 | vs CAL | 11 | L 6-11 | 7-4 | 3 | 3,776 | Roger Erickson | Chris Knapp | Dyar Miller | Roger Erickson | Mark Clear | 60 | 54 | 6 |
| 1979-04-19 | vs CAL | 12 | L 4-6 | 7-5 | 3 | 3,537 | Paul Hartzell | Don Aase | Don Aase | Mike Marshall | Dave LaRoche | 64 | 60 | 4 |
| 1979-04-21 | vs SEA | 13 | W 6-5 | 8-5 | 3 | 6,678 | Jerry Koosman | Floyd Bannister | Jerry Koosman | Floyd Bannister | Mike Marshall | 70 | 65 | 5 |
| 1979-04-22 | vs SEA | 14 | W 3-1 | 9-5 | 3 | 7,868 | Dave Goltz | Glenn Abbott | Dave Goltz | Glenn Abbott | | 73 | 66 | 7 |
| 1979-04-24 | @ CLE | 15 | L 2-7 | 9-6 | 3 | 3,902 | Roger Erickson | Rick Wise | Rick Wise | Roger Erickson | | 75 | 73 | 2 |
| 1979-04-25 | @ CLE | 16 | W 4-2 | 10-6 | 3 | 5,144 | Paul Hartzell | Eric Wilkins | Pete Redfern | Sid Monge | Mike Marshall | 79 | 75 | 4 |
| 1979-04-27 | @ DET | 17 | W 5-3 | 11-6 | 2 | 11,262 | Jerry Koosman | Dave Rozema | Jerry Koosman | Dave Rozema | Mike Marshall | 84 | 78 | 6 |
| 1979-04-28 | @ DET | 18 | L 3-5 | 11-7 | 2 | 8,818 | Dave Goltz | Kip Young | Kip Young | Dave Goltz | John Hiller | 87 | 83 | 4 |
| 1979-04-29 | @ DET | 19 | W 5-3 | 12-7 | 2 | 12,577 | Geoff Zahn | Milt Wilcox | Geoff Zahn | Milt Wilcox | Mike Marshall | 92 | 86 | 6 |
| 1979-04-30 | @ TOR | 20 | W 6-3 | 13-7 | 2 | 10,170 | Paul Hartzell | Mark Lemongello | Paul Hartzell | Mark Lemongello | | 98 | 89 | 9 |
| 1979-05-01 | @ TOR | 21 | W 3-2 | 14-7 | 1 | 10,155 | Jerry Koosman | Jesse Jefferson | Jerry Koosman | Jesse Jefferson | Mike Marshall | 101 | 91 | 10 |
| 1979-05-02 | @ TOR | 22 | W 7-5 | 15-7 | 1 | 20,110 | Dave Goltz | Phil Huffman | Dave Goltz | Phil Huffman | Mike Marshall | 108 | 96 | 12 |
| 1979-05-03 | vs DET | 23 | W 7-6 | 16-7 | 1 | 4,581 | Roger Erickson | Kip Young | Mike Marshall | Jack Billingham | | 115 | 102 | 13 |
| 1979-05-04 | vs DET | 24 | W 7-6 | 17-7 | 1 | 5,768 | Pete Redfern | Milt Wilcox | Mike Marshall | Aurelio Lopez | | 122 | 108 | 14 |
| 1979-05-05 | vs DET | 25 | L 4-8 | 17-8 | 1 | 15,002 | Paul Hartzell | Mark Fidrych | Jack Billingham | Paul Hartzell | | 126 | 116 | 10 |
| 1979-05-06 | vs DET | 26 | W 9-6 | 18-8 | 1 | 15,235 | Jerry Koosman | Steve Baker | Mike Marshall | John Hiller | | 135 | 122 | 13 |
| 1979-05-07 | vs TOR | 27 | W 6-1 | 19-8 | 1 | 4,571 | Dave Goltz | Phil Huffman | Dave Goltz | Phil Huffman | | 141 | 123 | 18 |
| 1979-05-08 | vs TOR | 28 | W 16-6 | 20-8 | 1 | 3,126 | Roger Erickson | Tom Underwood | Mike Bacsik | Mike Willis | | 157 | 129 | 28 |
| 1979-05-11 | vs CLE | 29 | W 4-3 | 21-8 | 1 | 4,121 | Paul Hartzell | Rick Wise | Mike Marshall | Sid Monge | | 161 | 132 | 29 |
| 1979-05-12 | vs CLE | 30 | W 4-0 | 22-8 | 1 | 8,090 | Jerry Koosman | Mike Paxton | Jerry Koosman | Mike Paxton | | 165 | 132 | 33 |
| 1979-05-13 | vs CLE | 31 | L 2-3 | 22-9 | 1 | 10,172 | Dave Goltz | Wayne Garland | Wayne Garland | Dave Goltz | Victor Cruz | 167 | 135 | 32 |
| 1979-05-14 | vs TEX | 32 | L 5-7 | 22-10 | 1 | 6,406 | Roger Erickson | Fergie Jenkins | Jim Kern | Mike Marshall | | 172 | 142 | 30 |
| 1979-05-15 | vs TEX | 33 | L 8-9 | 22-11 | 1 | 7,499 | Pete Redfern | Dock Ellis | Sparky Lyle | Mike Marshall | Jim Kern | 180 | 151 | 29 |
| 1979-05-16 | vs TEX | 34 | L 4-8 | 22-12 | 1 | 6,121 | Paul Hartzell | Jon Matlack | Jon Matlack | Paul Hartzell | Jim Kern | 184 | 159 | 25 |
| 1979-05-17 | @ KCA | 35 | W 7-6 | 23-12 | 1 | 21,437 | Jerry Koosman | Dennis Leonard | Jerry Koosman | Dennis Leonard | Mike Marshall | 191 | 165 | 26 |
| 1979-05-18 | @ KCA | 36 | W 10-6 | 24-12 | 1 | 21,475 | Dave Goltz | Marty Pattin | Mike Marshall | Renie Martin | | 201 | 171 | 30 |
| 1979-05-20 | @ KCA | 37 | L 1-5 | 24-13 | 1 | 39,661 | Roger Erickson | Paul Splittorff | Paul Splittorff | Roger Erickson | | 202 | 176 | 26 |
| 1979-05-21 | @ TEX | 38 | W 7-6 | 25-13 | 1 | 11,601 | Paul Hartzell | Jon Matlack | Pete Redfern | Sparky Lyle | Mike Marshall | 209 | 182 | 27 |
| 1979-05-22 | @ TEX | 39 | L 3-4 | 25-14 | 1 | 11,955 | Jerry Koosman | Steve Comer | Jim Kern | Jerry Koosman | | 212 | 186 | 26 |
| 1979-05-23 | @ TEX | 40 | L 2-7 | 25-15 | 1 | 17,909 | Dave Goltz | Fergie Jenkins | Fergie Jenkins | Dave Goltz | | 214 | 193 | 21 |
| 1979-05-25 | vs KCA | 41 | L 3-4 | 25-16 | 1 | 9,606 | Roger Erickson | Paul Splittorff | Paul Splittorff | Mike Marshall | Al Hrabosky | 217 | 197 | 20 |
| 1979-05-26 | vs KCA | 42 | L 4-7 | 25-17 | 1 | 9,023 | Paul Hartzell | Rich Gale | Rich Gale | Paul Hartzell | Al Hrabosky | 221 | 204 | 17 |
| 1979-05-27 | vs KCA | 43 | L 1-2 | 25-18 | 2 | 35,148 | Jerry Koosman | Steve Busby | Steve Busby | Jerry Koosman | | 222 | 206 | 16 |
| 1979-05-28 | vs OAK | 44 | W 10-7 | 26-18 | 2 | 9,505 | Dave Goltz | John Henry Johnson | Mike Marshall | Dave Heaverlo | | 232 | 213 | 19 |
| 1979-05-30 | vs OAK | 45 | L 4-5 | 26-19 | 3 | 3,073 | Roger Erickson | Matt Keough | John Henry Johnson | Roger Erickson | Bob Lacey | 236 | 218 | 18 |
| 1979-05-31 | vs OAK | 46 | W 13-2 | 27-19 | 2 | 4,345 | Paul Hartzell | Rick Langford | Paul Hartzell | Rick Langford | | 249 | 220 | 29 |
| 1979-06-01 | vs BOS | 47 | L 2-5 | 27-20 | 3 | 15,871 | Jerry Koosman | Bob Stanley | Bob Stanley | Jerry Koosman | Bill Campbell | 251 | 225 | 26 |
| 1979-06-02 | vs BOS | 48 | W 8-2 | 28-20 | 2 | 14,701 | Dave Goltz | Chuck Rainey | Dave Goltz | Chuck Rainey | | 259 | 227 | 32 |
| 1979-06-03 | vs BOS | 49 | L 2-8 | 28-21 | 4 | 17,353 | Geoff Zahn | Steve Renko | Steve Renko | Geoff Zahn | Bill Campbell | 261 | 235 | 26 |
| 1979-06-04 | @ BAL | 50 | L 2-3 | 28-22 | 4 | 11,905 | Roger Erickson | Mike Flanagan | Don Stanhouse | Mike Marshall | | 263 | 238 | 25 |
| 1979-06-05 | @ BAL | 51 | W 3-1 | 29-22 | 3 | 11,036 | Paul Hartzell | Steve Stone | Paul Hartzell | Steve Stone | Mike Marshall | 266 | 239 | 27 |
| 1979-06-06 | @ NYA | 52 | L 2-3 | 29-23 | 3 | 34,075 | Jerry Koosman | Ron Guidry | Ron Guidry | Jerry Koosman | | 268 | 242 | 26 |
| 1979-06-07 | @ NYA | 53 | W 4-1 | 30-23 | 2 | 20,722 | Geoff Zahn | Jim Beattie | Geoff Zahn | Jim Beattie | Mike Marshall | 272 | 243 | 29 |
| 1979-06-08 | @ BOS | 54 | L 1-2 | 30-24 | 2 | 33,953 | Dave Goltz | Steve Renko | Bob Stanley | Dave Goltz | | 273 | 245 | 28 |
| 1979-06-09 | @ BOS | 55 | L 6-12 | 30-25 | 3 | 34,324 | Roger Erickson | Mike Torrez | Mike Torrez | Roger Erickson | | 279 | 257 | 22 |
| 1979-06-10 | @ BOS | 56 | L 0-5 | 30-26 | 3 | 34,304 | Paul Hartzell | Dennis Eckersley | Dennis Eckersley | Paul Hartzell | | 279 | 262 | 17 |
| 1979-06-12 | vs NYA | 57 | L 1-4 | 30-27 | 4 | 27,733 | Jerry Koosman | Ron Guidry | Ron Davis | Jerry Koosman | | 280 | 266 | 14 |
| 1979-06-13 | vs NYA | 58 | W 8-7 | 31-27 | 2 | 19,660 | Dave Goltz | Jim Beattie | Pete Redfern | Ray Burris | Mike Marshall | 288 | 273 | 15 |
| 1979-06-14 | vs NYA | 59 | W 4-2 | 32-27 | 2 | 24,129 | Geoff Zahn | Tommy John | Geoff Zahn | Tommy John | Mike Marshall | 292 | 275 | 17 |
| 1979-06-15 | vs BAL | 60 | L 5-6 | 32-28 | 3 | 11,831 | Paul Hartzell | Dennis Martinez | Don Stanhouse | Mike Marshall | Tim Stoddard | 297 | 281 | 16 |
| 1979-06-17 | vs BAL | 61 | L 5-8 | 32-29 | 3 | 15,966 | Jerry Koosman | Mike Flanagan | Mike Flanagan | Jerry Koosman | Tim Stoddard | 302 | 289 | 13 |
| 1979-06-19 | @ MIL | 62 | L 9-10 | 32-30 | 4 | 17,741 | Dave Goltz | Moose Haas | Bob McClure | Mike Bacsik | Jerry Augustine | 311 | 299 | 12 |
| 1979-06-20 | @ MIL | 63 | L 3-8 | 32-31 | 4 | 21,404 | Paul Hartzell | Bill Travers | Bill Travers | Paul Hartzell | | 314 | 307 | 7 |
| 1979-06-21 | @ MIL | 64 | L 2-3 | 32-32 | 4 | 32,339 | Gary Serum | Mike Caldwell | Mike Caldwell | Gary Serum | | 316 | 310 | 6 |
| 1979-06-22 | @ CHA | 65 | W 5-3 | 33-32 | 4 | 28,029 | Geoff Zahn | Ken Kravec | Geoff Zahn | Ken Kravec | Mike Marshall | 321 | 313 | 8 |
| 1979-06-23 | @ CHA | 66 | W 6-1 | 34-32 | 4 | 20,797 | Dave Goltz | Ross Baumgarten | Dave Goltz | Ross Baumgarten | | 327 | 314 | 13 |
| 1979-06-24 | @ CHA | 67 | W 4-3 | 36-32 | 4 | 0 | Darrell Jackson | Rich Wortham | Mike Bacsik | Rich Wortham | | 331 | 317 | 14 |
| 1979-06-24 | @ CHA | 68 | W 7-1 | 36-32 | 4 | 20,655 | Jerry Koosman | Ed Farmer | Jerry Koosman | Ed Farmer | | 338 | 318 | 20 |
| 1979-06-26 | vs MIL | 69 | W 8-7 | 37-32 | 4 | 21,711 | Paul Hartzell | Bill Travers | Mike Marshall | Jerry Augustine | | 346 | 325 | 21 |
| 1979-06-27 | vs MIL | 70 | L 8-9 | 37-33 | 4 | 18,602 | Gary Serum | Mike Caldwell | Mike Caldwell | Gary Serum | Jerry Augustine | 354 | 334 | 20 |
| 1979-06-28 | vs MIL | 71 | L 5-6 | 37-34 | 4 | 22,224 | Dave Goltz | Jim Slaton | Bill Castro | Mike Marshall | | 359 | 340 | 19 |
| 1979-06-29 | vs CHA | 72 | W 5-2 | 38-34 | 4 | 12,763 | Jerry Koosman | Rich Wortham | Jerry Koosman | Rich Wortham | | 364 | 342 | 22 |
| 1979-06-30 | vs CHA | 73 | W 16-4 | 39-34 | 4 | 11,919 | Geoff Zahn | Ed Farmer | Geoff Zahn | Ed Farmer | | 380 | 346 | 34 |
| 1979-07-01 | vs CHA | 74 | W 2-1 | 40-34 | 3 | 24,904 | Paul Hartzell | Steve Trout | Paul Hartzell | Fred Howard | | 382 | 347 | 35 |
| 1979-07-02 | vs SEA | 75 | W 7-0 | 41-34 | 3 | 6,629 | Darrell Jackson | Odell Jones | Darrell Jackson | Odell Jones | | 389 | 347 | 42 |
| 1979-07-03 | vs SEA | 76 | W 12-2 | 42-35 | 3 | 0 | Dave Goltz | Mike Parrott | Pete Redfern | Mike Parrott | | 401 | 349 | 52 |
| 1979-07-03 | vs SEA | 77 | L 2-10 | 42-35 | 3 | 12,422 | Gary Serum | Byron McLaughlin | Byron McLaughlin | Gary Serum | | 403 | 359 | 44 |
| 1979-07-04 | vs SEA | 78 | W 7-2 | 43-35 | 3 | 34,365 | Jerry Koosman | Glenn Abbott | Jerry Koosman | Glenn Abbott | | 410 | 361 | 49 |
| 1979-07-05 | vs SEA | 79 | L 0-4 | 43-36 | 3 | 8,422 | Geoff Zahn | Rick Honeycutt | Rick Honeycutt | Geoff Zahn | | 410 | 365 | 45 |
| 1979-07-06 | @ CLE | 80 | L 5-6 | 43-37 | 3 | 13,348 | Paul Hartzell | Len Barker | Dan Spillner | Paul Hartzell | Sid Monge | 415 | 371 | 44 |
| 1979-07-07 | @ CLE | 81 | L 3-9 | 43-38 | 3 | 10,589 | Darrell Jackson | Mike Paxton | Mike Paxton | Darrell Jackson | | 418 | 380 | 38 |
| 1979-07-08 | @ CLE | 82 | L 4-5 | 44-39 | 3 | 0 | Gary Serum | Rick Wise | Victor Cruz | Mike Marshall | | 422 | 385 | 37 |
| 1979-07-08 | @ CLE | 83 | W 7-2 | 44-39 | 3 | 19,592 | Dave Goltz | Rick Waits | Dave Goltz | Rick Waits | | 429 | 387 | 42 |
| 1979-07-09 | @ DET | 84 | W 5-3 | 45-39 | 3 | 15,742 | Jerry Koosman | Steve Baker | Jerry Koosman | Steve Baker | Mike Marshall | 434 | 390 | 44 |
| 1979-07-10 | @ DET | 85 | L 5-6 | 45-40 | 3 | 17,747 | Geoff Zahn | Kip Young | Aurelio Lopez | Mike Marshall | | 439 | 396 | 43 |
| 1979-07-11 | @ DET | 86 | W 3-0 | 46-40 | 3 | 16,180 | Darrell Jackson | Jack Morris | Darrell Jackson | Jack Morris | Pete Redfern | 442 | 396 | 46 |
| 1979-07-13 | @ TOR | 87 | W 6-4 | 47-40 | 3 | 14,095 | Dave Goltz | Dave Lemanczyk | Dave Goltz | Dave Lemanczyk | Mike Marshall | 448 | 400 | 48 |
| 1979-07-14 | @ TOR | 88 | L 2-4 | 47-41 | 3 | 19,187 | Jerry Koosman | Dave Stieb | Dave Stieb | Jerry Koosman | | 450 | 404 | 46 |
| 1979-07-15 | @ TOR | 89 | W 9-4 | 48-41 | 3 | 19,069 | Geoff Zahn | Jim Clancy | Geoff Zahn | Jim Clancy | | 459 | 408 | 51 |
| 1979-07-19 | vs DET | 90 | L 3-8 | 48-42 | 3 | 17,391 | Jerry Koosman | Pat Underwood | Pat Underwood | Jerry Koosman | | 462 | 416 | 46 |
| 1979-07-20 | vs DET | 91 | W 14-6 | 49-42 | 3 | 14,509 | Darrell Jackson | Jack Morris | Gary Serum | Kip Young | | 476 | 422 | 54 |
| 1979-07-21 | vs TOR | 92 | W 6-4 | 51-42 | 3 | 0 | Dave Goltz | Phil Huffman | Dave Goltz | Phil Huffman | Mike Marshall | 482 | 426 | 56 |
| 1979-07-21 | vs TOR | 93 | W 4-3 | 51-42 | 3 | 12,887 | Paul Hartzell | Balor Moore | Paul Hartzell | Balor Moore | | 486 | 429 | 57 |
| 1979-07-22 | vs TOR | 94 | W 13-1 | 52-42 | 2 | 18,927 | Pete Redfern | Dave Lemanczyk | Pete Redfern | Dave Lemanczyk | | 499 | 430 | 69 |
| 1979-07-23 | vs TOR | 95 | W 7-6 | 53-42 | 2 | 7,482 | Geoff Zahn | Jim Clancy | Mike Marshall | Mark Lemongello | | 506 | 436 | 70 |
| 1979-07-24 | vs CLE | 96 | L 2-4 | 53-43 | 2 | 10,243 | Jerry Koosman | Rick Wise | Rick Wise | Jerry Koosman | | 508 | 440 | 68 |
| 1979-07-25 | vs CLE | 97 | L 0-2 | 53-44 | 2 | 10,762 | Dave Goltz | Rick Waits | Rick Waits | Dave Goltz | | 508 | 442 | 66 |
| 1979-07-26 | vs CLE | 98 | L 2-7 | 53-45 | 2 | 18,728 | Paul Hartzell | Dan Spillner | Dan Spillner | Pete Redfern | Sid Monge | 510 | 449 | 61 |
| 1979-07-27 | @ CAL | 99 | W 3-1 | 54-45 | 2 | 38,945 | Geoff Zahn | Dave Frost | Geoff Zahn | Dave Frost | Mike Marshall | 513 | 450 | 63 |
| 1979-07-28 | @ CAL | 100 | L 0-5 | 54-46 | 2 | 41,891 | Jerry Koosman | Don Aase | Don Aase | Jerry Koosman | | 513 | 455 | 58 |
| 1979-07-29 | @ CAL | 101 | L 3-9 | 54-47 | 2 | 33,510 | Darrell Jackson | Steve Eddy | Steve Eddy | Darrell Jackson | Dave LaRoche | 516 | 464 | 52 |
| 1979-07-30 | @ OAK | 102 | W 3-0 | 55-47 | 2 | 5,857 | Dave Goltz | Brian Kingman | Dave Goltz | Brian Kingman | | 519 | 464 | 55 |
| 1979-07-31 | @ OAK | 103 | L 1-2 | 55-48 | 2 | 1,763 | Geoff Zahn | Steve McCatty | Steve McCatty | Geoff Zahn | | 520 | 466 | 54 |
| 1979-08-01 | @ OAK | 104 | L 1-7 | 55-49 | 3 | 5,711 | Paul Hartzell | Rick Langford | Rick Langford | Paul Hartzell | | 521 | 473 | 48 |
| 1979-08-03 | vs CAL | 105 | W 4-1 | 56-49 | 3 | 30,653 | Jerry Koosman | Jim Barr | Jerry Koosman | Jim Barr | Mike Marshall | 525 | 474 | 51 |
| 1979-08-04 | vs CAL | 106 | L 1-7 | 56-50 | 3 | 26,084 | Dave Goltz | Dave Frost | Dave Frost | Dave Goltz | Mark Clear | 526 | 481 | 45 |
| 1979-08-05 | vs CAL | 107 | L 7-11 | 57-51 | 3 | 0 | Geoff Zahn | Don Aase | Dave LaRoche | Roger Erickson | Mark Clear | 533 | 492 | 41 |
| 1979-08-05 | vs CAL | 108 | W 7-1 | 57-51 | 3 | 41,182 | Pete Redfern | Steve Eddy | Pete Redfern | Steve Eddy | Mike Marshall | 540 | 493 | 47 |
| 1979-08-06 | @ SEA | 109 | L 4-7 | 57-52 | 3 | 7,193 | Darrell Jackson | Rick Honeycutt | Rick Honeycutt | Darrell Jackson | Byron McLaughlin | 544 | 500 | 44 |
| 1979-08-07 | @ SEA | 110 | W 5-2 | 58-52 | 2 | 8,288 | Jerry Koosman | Rich Hinton | Jerry Koosman | Rich Hinton | Mike Marshall | 549 | 502 | 47 |
| 1979-08-08 | @ SEA | 111 | W 3-1 | 59-52 | 2 | 8,222 | Dave Goltz | Floyd Bannister | Dave Goltz | Floyd Bannister | Mike Marshall | 552 | 503 | 49 |
| 1979-08-10 | vs OAK | 112 | L 5-6 | 60-53 | 2 | 0 | Pete Redfern | Mike Morgan | Dave Heaverlo | Mike Marshall | | 557 | 509 | 48 |
| 1979-08-10 | vs OAK | 113 | W 3-2 | 60-53 | 2 | 13,742 | Roger Erickson | Brian Kingman | Darrell Jackson | Dave Heaverlo | | 560 | 511 | 49 |
| 1979-08-11 | vs OAK | 114 | W 9-7 | 61-53 | 2 | 9,535 | Gary Serum | Steve McCatty | Mike Bacsik | Steve McCatty | Mike Marshall | 569 | 518 | 51 |
| 1979-08-12 | vs OAK | 115 | W 1-0 | 62-53 | 2 | 14,500 | Jerry Koosman | Rick Langford | Jerry Koosman | Rick Langford | | 570 | 518 | 52 |
| 1979-08-13 | @ BOS | 116 | L 5-6 | 62-54 | 2 | 32,359 | Dave Goltz | Bob Stanley | Tom Burgmeier | Mike Marshall | Dick Drago | 575 | 524 | 51 |
| 1979-08-14 | @ BOS | 117 | L 1-12 | 62-55 | 2 | 32,962 | Pete Redfern | Dennis Eckersley | Dennis Eckersley | Pete Redfern | | 576 | 536 | 40 |
| 1979-08-15 | @ BOS | 118 | L 5-9 | 62-56 | 2 | 33,539 | Roger Erickson | Mike Torrez | Dick Drago | Mike Bacsik | | 581 | 545 | 36 |
| 1979-08-16 | @ NYA | 119 | W 5-1 | 63-56 | 2 | 22,036 | Geoff Zahn | Catfish Hunter | Geoff Zahn | Catfish Hunter | | 586 | 546 | 40 |
| 1979-08-17 | @ NYA | 120 | W 5-2 | 64-56 | 2 | 30,372 | Jerry Koosman | Jim Beattie | Jerry Koosman | Jim Beattie | | 591 | 548 | 43 |
| 1979-08-18 | @ NYA | 121 | L 3-5 | 64-57 | 2 | 38,695 | Mike Marshall | Jim Kaat | Ron Davis | Mike Marshall | Rich Gossage | 594 | 553 | 41 |
| 1979-08-19 | @ NYA | 122 | L 3-4 | 64-58 | 2 | 47,723 | Darrell Jackson | Ron Guidry | Ron Guidry | Darrell Jackson | Rich Gossage | 597 | 557 | 40 |
| 1979-08-20 | vs BOS | 123 | W 10-5 | 65-58 | 2 | 13,895 | Roger Erickson | Mike Torrez | Roger Erickson | Mike Torrez | | 607 | 562 | 45 |
| 1979-08-21 | vs BOS | 124 | W 7-2 | 66-58 | 2 | 19,386 | Jerry Koosman | John Tudor | Jerry Koosman | John Tudor | | 614 | 564 | 50 |
| 1979-08-22 | vs BOS | 125 | L 4-9 | 66-59 | 2 | 24,356 | Dave Goltz | Bob Stanley | Bob Stanley | Dave Goltz | | 618 | 573 | 45 |
| 1979-08-24 | vs NYA | 126 | L 5-7 | 66-60 | 2 | 29,800 | Geoff Zahn | Ron Guidry | Ron Guidry | Geoff Zahn | Rich Gossage | 623 | 580 | 43 |
| 1979-08-25 | vs NYA | 127 | W 4-1 | 67-60 | 2 | 36,363 | Jerry Koosman | Luis Tiant | Jerry Koosman | Luis Tiant | Mike Marshall | 627 | 581 | 46 |
| 1979-08-27 | vs BAL | 128 | W 4-3 | 68-61 | 3 | 0 | Paul Hartzell | Dennis Martinez | Pete Redfern | Dennis Martinez | Mike Marshall | 631 | 584 | 47 |
| 1979-08-27 | vs BAL | 129 | L 1-5 | 68-61 | 3 | 17,207 | Dave Goltz | Jim Palmer | Jim Palmer | Dave Goltz | | 632 | 589 | 43 |
| 1979-08-29 | vs BAL | 130 | L 0-4 | 68-63 | 3 | 0 | Roger Erickson | Scott McGregor | Scott McGregor | Roger Erickson | | 632 | 593 | 39 |
| 1979-08-29 | vs BAL | 131 | L 4-7 | 68-63 | 3 | 11,470 | Geoff Zahn | Dave Ford | Dave Ford | Geoff Zahn | Don Stanhouse | 636 | 600 | 36 |
| 1979-08-30 | @ BAL | 132 | L 4-5 | 68-64 | 3 | 24,461 | Jerry Koosman | Mike Flanagan | Mike Flanagan | Jerry Koosman | Don Stanhouse | 640 | 605 | 35 |
| 1979-08-31 | @ BAL | 133 | W 3-1 | 69-64 | 3 | 30,816 | Dave Goltz | Dennis Martinez | Dave Goltz | Dennis Martinez | Mike Marshall | 643 | 606 | 37 |
| 1979-09-01 | @ BAL | 134 | W 3-2 | 70-64 | 3 | 36,146 | Paul Hartzell | Jim Palmer | Paul Hartzell | Jim Palmer | Mike Marshall | 646 | 608 | 38 |
| 1979-09-02 | @ BAL | 135 | L 1-3 | 70-65 | 3 | 18,074 | Roger Erickson | Scott McGregor | Scott McGregor | Roger Erickson | | 647 | 611 | 36 |
| 1979-09-03 | vs KCA | 136 | L 0-1 | 70-66 | 3 | 19,643 | Geoff Zahn | Dennis Leonard | Dennis Leonard | Geoff Zahn | | 647 | 612 | 35 |
| 1979-09-04 | vs KCA | 137 | W 5-1 | 71-66 | 3 | 10,610 | Jerry Koosman | Larry Gura | Jerry Koosman | Larry Gura | | 652 | 613 | 39 |
| 1979-09-05 | vs KCA | 138 | W 8-3 | 72-66 | 3 | 11,647 | Dave Goltz | Paul Splittorff | Dave Goltz | Paul Splittorff | | 660 | 616 | 44 |
| 1979-09-07 | vs TEX | 139 | L 4-5 | 72-67 | 3 | 10,793 | Geoff Zahn | Doyle Alexander | Sparky Lyle | Mike Marshall | Jim Kern | 664 | 621 | 43 |
| 1979-09-08 | vs TEX | 140 | L 2-6 | 72-68 | 3 | 15,382 | Jerry Koosman | Doc Medich | Doc Medich | Jerry Koosman | Jim Kern | 666 | 627 | 39 |
| 1979-09-09 | vs TEX | 141 | L 5-6 | 72-69 | 3 | 9,261 | Paul Hartzell | Steve Comer | Steve Comer | Paul Hartzell | Jim Kern | 671 | 633 | 38 |
| 1979-09-10 | @ KCA | 142 | L 5-6 | 73-70 | 3 | 0 | Roger Erickson | Marty Pattin | Dan Quisenberry | Mike Marshall | | 676 | 639 | 37 |
| 1979-09-10 | @ KCA | 143 | W 5-2 | 73-70 | 3 | 31,337 | Dave Goltz | Paul Splittorff | Dave Goltz | Paul Splittorff | | 681 | 641 | 40 |
| 1979-09-11 | @ KCA | 144 | W 3-1 | 74-70 | 3 | 21,253 | Geoff Zahn | Craig Chamberlain | Geoff Zahn | Craig Chamberlain | Mike Marshall | 684 | 642 | 42 |
| 1979-09-12 | @ KCA | 145 | L 0-4 | 74-71 | 3 | 20,524 | Jerry Koosman | Dennis Leonard | Dennis Leonard | Jerry Koosman | | 684 | 646 | 38 |
| 1979-09-13 | @ TEX | 146 | W 7-4 | 75-71 | 3 | 8,562 | Paul Hartzell | Steve Comer | Darrell Jackson | Jim Kern | | 691 | 650 | 41 |
| 1979-09-14 | @ TEX | 147 | L 3-5 | 75-72 | 3 | 10,082 | Dave Goltz | Fergie Jenkins | Fergie Jenkins | Dave Goltz | Sparky Lyle | 694 | 655 | 39 |
| 1979-09-15 | @ TEX | 148 | W 11-4 | 76-72 | 3 | 20,619 | Geoff Zahn | Doyle Alexander | Geoff Zahn | Doyle Alexander | | 705 | 659 | 46 |
| 1979-09-16 | @ TEX | 149 | W 6-2 | 77-72 | 3 | 6,853 | Roger Erickson | Doc Medich | Roger Erickson | Doc Medich | | 711 | 661 | 50 |
| 1979-09-17 | @ CHA | 150 | W 10-3 | 78-72 | 3 | 5,003 | Jerry Koosman | Rich Wortham | Mike Bacsik | Rich Wortham | | 721 | 664 | 57 |
| 1979-09-18 | @ CHA | 151 | L 0-1 | 78-73 | 3 | 5,196 | Dave Goltz | Ken Kravec | Ken Kravec | Dave Goltz | | 721 | 665 | 56 |
| 1979-09-19 | @ CHA | 152 | L 0-6 | 78-74 | 3 | 3,751 | Paul Hartzell | Ross Baumgarten | Ross Baumgarten | Paul Hartzell | | 721 | 671 | 50 |
| 1979-09-20 | vs NYA | 153 | W 3-1 | 79-74 | 3 | 5,357 | Geoff Zahn | Dave Righetti | Geoff Zahn | Dave Righetti | | 724 | 672 | 52 |
| 1979-09-21 | @ MIL | 154 | W 3-2 | 80-74 | 3 | 10,791 | Jerry Koosman | Moose Haas | Jerry Koosman | Moose Haas | Mike Marshall | 727 | 674 | 53 |
| 1979-09-22 | @ MIL | 155 | W 6-3 | 81-74 | 3 | 18,263 | Roger Erickson | Jim Slaton | Roger Erickson | Jim Slaton | Mike Marshall | 733 | 677 | 56 |
| 1979-09-23 | @ MIL | 156 | L 7-8 | 81-75 | 3 | 12,097 | Dave Goltz | Mike Caldwell | Jerry Augustine | Pete Redfern | | 740 | 685 | 55 |
| 1979-09-25 | vs CHA | 157 | L 3-9 | 81-76 | 3 | 5,275 | Geoff Zahn | Ken Kravec | Ken Kravec | Geoff Zahn | | 743 | 694 | 49 |
| 1979-09-26 | vs CHA | 158 | L 5-6 | 81-77 | 3 | 4,458 | Jerry Koosman | Ross Baumgarten | Ed Farmer | Mike Marshall | | 748 | 700 | 48 |
| 1979-09-27 | vs CHA | 159 | L 2-4 | 81-78 | 3 | 3,797 | Dave Goltz | Richard Dotson | Mike Proly | Dave Goltz | Ed Farmer | 750 | 704 | 46 |
| 1979-09-28 | vs MIL | 160 | L 1-10 | 81-79 | 4 | 14,376 | Roger Erickson | Mike Caldwell | Mike Caldwell | Roger Erickson | | 751 | 714 | 37 |
| 1979-09-29 | vs MIL | 161 | L 8-11 | 81-80 | 4 | 8,658 | Paul Hartzell | Paul Mitchell | Paul Mitchell | Paul Hartzell | Bob McClure | 759 | 725 | 34 |
| 1979-09-30 | vs MIL | 162 | W 5-0 | 82-80 | 4 | 10,277 | Jerry Koosman | Lary Sorensen | Jerry Koosman | Lary Sorensen | | 764 | 725 | 39 |