| 1979-04-05 | vs SDN | 1 | L 3-4 | 0-1 | 6 | 46,536 | Burt Hooton | Gaylord Perry | Gaylord Perry | Lance Rautzhan | Rollie Fingers | 3 | 4 | -1 |
| 1979-04-06 | vs SDN | 2 | W 10-1 | 1-1 | 3 | 35,979 | Don Sutton | Randy Jones | Don Sutton | Randy Jones | | 13 | 5 | 8 |
| 1979-04-07 | vs SDN | 3 | W 5-2 | 2-1 | 3 | 44,327 | Andy Messersmith | Eric Rasmussen | Andy Messersmith | Eric Rasmussen | Lance Rautzhan | 18 | 7 | 11 |
| 1979-04-08 | vs SDN | 4 | W 6-5 | 3-1 | 2 | 39,562 | Doug Rau | Bob Owchinko | Rick Sutcliffe | Bob Shirley | | 24 | 12 | 12 |
| 1979-04-09 | @ HOU | 5 | W 2-1 | 4-1 | 1 | 12,116 | Bob Welch | Vern Ruhle | Bob Welch | Vern Ruhle | Jerry Reuss | 26 | 13 | 13 |
| 1979-04-10 | @ HOU | 6 | L 1-2 | 4-2 | 3 | 14,091 | Burt Hooton | J.R. Richard | J.R. Richard | Burt Hooton | | 27 | 15 | 12 |
| 1979-04-11 | @ HOU | 7 | L 3-10 | 4-3 | 3 | 15,964 | Don Sutton | Ken Forsch | Ken Forsch | Don Sutton | | 30 | 25 | 5 |
| 1979-04-12 | vs ATL | 8 | L 2-10 | 4-4 | 3 | 27,510 | Andy Messersmith | Larry McWilliams | Larry McWilliams | Andy Messersmith | | 32 | 35 | -3 |
| 1979-04-13 | vs ATL | 9 | L 1-2 | 4-5 | 4 | 42,284 | Doug Rau | Rick Matula | Rick Matula | Doug Rau | Gene Garber | 33 | 37 | -4 |
| 1979-04-14 | vs ATL | 10 | W 6-5 | 5-5 | 3 | 47,064 | Bob Welch | Phil Niekro | Bob Welch | Phil Niekro | Jerry Reuss | 39 | 42 | -3 |
| 1979-04-15 | vs ATL | 11 | L 4-11 | 5-6 | 4 | 32,799 | Burt Hooton | Eddie Solomon | Eddie Solomon | Burt Hooton | Gene Garber | 43 | 53 | -10 |
| 1979-04-16 | vs HOU | 12 | L 0-4 | 5-7 | 4 | 29,092 | Don Sutton | Ken Forsch | Ken Forsch | Don Sutton | | 43 | 57 | -14 |
| 1979-04-17 | vs HOU | 13 | W 10-6 | 6-7 | 4 | 27,635 | Andy Messersmith | Joe Niekro | Jerry Reuss | Tom Dixon | | 53 | 63 | -10 |
| 1979-04-18 | vs HOU | 14 | L 0-4 | 6-8 | 5 | 30,811 | Doug Rau | Vern Ruhle | Vern Ruhle | Doug Rau | | 53 | 67 | -14 |
| 1979-04-20 | @ SFN | 15 | L 2-3 | 6-9 | 5 | 39,906 | Bob Welch | John Montefusco | Gary Lavelle | Jerry Reuss | | 55 | 70 | -15 |
| 1979-04-21 | @ SFN | 16 | W 2-1 | 7-9 | 5 | 37,775 | Burt Hooton | Bob Knepper | Burt Hooton | Tom Griffin | | 57 | 71 | -14 |
| 1979-04-22 | @ SFN | 17 | W 9-2 | 8-9 | 4 | 51,711 | Don Sutton | Ed Halicki | Don Sutton | Ed Halicki | | 66 | 73 | -7 |
| 1979-04-23 | @ PHI | 18 | L 3-4 | 8-10 | 5 | 32,826 | Andy Messersmith | Randy Lerch | Tug McGraw | Lance Rautzhan | | 69 | 77 | -8 |
| 1979-04-24 | @ PHI | 19 | L 6-7 | 8-11 | 5 | 31,140 | Doug Rau | Jim Kaat | Ron Reed | Jerry Reuss | | 75 | 84 | -9 |
| 1979-04-25 | @ PHI | 20 | L 4-5 | 8-12 | 5 | 34,303 | Bob Welch | Dick Ruthven | Ron Reed | Rick Sutcliffe | | 79 | 89 | -10 |
| 1979-04-28 | @ NYN | 21 | W 3-1 | 9-12 | 3 | 11,426 | Burt Hooton | Pete Falcone | Burt Hooton | Pete Falcone | | 82 | 90 | -8 |
| 1979-04-29 | @ NYN | 22 | W 8-3 | 10-13 | 3 | 0 | Don Sutton | Neil Allen | Don Sutton | Neil Allen | | 90 | 93 | -3 |
| 1979-04-29 | @ NYN | 23 | L 3-6 | 10-13 | 3 | 19,982 | Andy Messersmith | Mike Scott | Dale Murray | Rick Sutcliffe | Skip Lockwood | 93 | 99 | -6 |
| 1979-04-30 | @ MON | 24 | L 4-8 | 10-14 | 3 | 11,435 | Doug Rau | Steve Rogers | Steve Rogers | Doug Rau | | 97 | 107 | -10 |
| 1979-05-01 | @ MON | 25 | L 3-7 | 10-15 | 5 | 11,621 | Bob Welch | Bill Lee | Bill Lee | Bob Welch | Elias Sosa | 100 | 114 | -14 |
| 1979-05-03 | vs PHI | 26 | W 5-2 | 11-15 | 5 | 41,215 | Rick Sutcliffe | Steve Carlton | Rick Sutcliffe | Steve Carlton | | 105 | 116 | -11 |
| 1979-05-04 | vs PHI | 27 | L 2-5 | 11-16 | 5 | 42,717 | Don Sutton | Randy Lerch | Randy Lerch | Don Sutton | | 107 | 121 | -14 |
| 1979-05-05 | vs PHI | 28 | L 0-11 | 11-17 | 5 | 45,169 | Andy Messersmith | Dick Ruthven | Dick Ruthven | Andy Messersmith | | 107 | 132 | -25 |
| 1979-05-06 | vs PHI | 29 | L 0-4 | 11-18 | 5 | 42,184 | Doug Rau | Nino Espinosa | Nino Espinosa | Doug Rau | | 107 | 136 | -29 |
| 1979-05-07 | vs NYN | 30 | W 5-2 | 12-18 | 5 | 27,230 | Burt Hooton | Pete Falcone | Burt Hooton | Pete Falcone | Bob Welch | 112 | 138 | -26 |
| 1979-05-08 | vs NYN | 31 | W 3-2 | 13-18 | 4 | 27,092 | Rick Sutcliffe | Mike Scott | Rick Sutcliffe | Dale Murray | Bob Welch | 115 | 140 | -25 |
| 1979-05-09 | vs NYN | 32 | W 7-2 | 14-18 | 4 | 23,313 | Don Sutton | Neil Allen | Don Sutton | Neil Allen | | 122 | 142 | -20 |
| 1979-05-10 | vs NYN | 33 | W 14-1 | 15-18 | 3 | 26,399 | Andy Messersmith | Craig Swan | Andy Messersmith | Craig Swan | | 136 | 143 | -7 |
| 1979-05-11 | vs MON | 34 | W 7-0 | 16-18 | 3 | 43,297 | Doug Rau | Bill Lee | Doug Rau | Bill Lee | | 143 | 143 | 0 |
| 1979-05-12 | vs MON | 35 | W 4-3 | 17-18 | 3 | 39,310 | Burt Hooton | Scott Sanderson | Bob Welch | Stan Bahnsen | | 147 | 146 | 1 |
| 1979-05-13 | vs MON | 36 | W 8-2 | 18-18 | 3 | 47,596 | Rick Sutcliffe | Ross Grimsley | Rick Sutcliffe | Ross Grimsley | Jerry Reuss | 155 | 148 | 7 |
| 1979-05-15 | @ ATL | 37 | W 5-4 | 19-18 | 3 | 8,139 | Don Sutton | Rick Matula | Bob Welch | Adrian Devine | | 160 | 152 | 8 |
| 1979-05-16 | @ ATL | 38 | L 2-3 | 19-19 | 3 | 6,277 | Andy Messersmith | Eddie Solomon | Eddie Solomon | Andy Messersmith | Gene Garber | 162 | 155 | 7 |
| 1979-05-17 | @ ATL | 39 | L 3-6 | 19-20 | 4 | 12,079 | Doug Rau | Phil Niekro | Phil Niekro | Charlie Hough | | 165 | 161 | 4 |
| 1979-05-18 | @ CIN | 40 | L 6-7 | 19-21 | 4 | 34,192 | Burt Hooton | Mike LaCoss | Pedro Borbon | Jerry Reuss | | 171 | 168 | 3 |
| 1979-05-19 | @ CIN | 41 | L 4-5 | 19-22 | 4 | 46,753 | Rick Sutcliffe | Paul Moskau | Paul Moskau | Rick Sutcliffe | Pedro Borbon | 175 | 173 | 2 |
| 1979-05-20 | @ CIN | 42 | W 6-4 | 20-22 | 4 | 40,087 | Don Sutton | Tom Seaver | Don Sutton | Tom Hume | Bob Welch | 181 | 177 | 4 |
| 1979-05-21 | @ SDN | 43 | L 2-3 | 20-23 | 4 | 20,981 | Andy Messersmith | Eric Rasmussen | Eric Rasmussen | Andy Messersmith | | 183 | 180 | 3 |
| 1979-05-22 | @ SDN | 44 | L 6-7 | 20-24 | 4 | 29,830 | Doug Rau | Bob Owchinko | Rollie Fingers | Jerry Reuss | | 189 | 187 | 2 |
| 1979-05-23 | @ SDN | 45 | W 4-2 | 21-24 | 4 | 29,158 | Burt Hooton | Randy Jones | Burt Hooton | Randy Jones | | 193 | 189 | 4 |
| 1979-05-25 | vs CIN | 46 | W 17-6 | 22-24 | 4 | 49,372 | Rick Sutcliffe | Tom Seaver | Rick Sutcliffe | Tom Seaver | | 210 | 195 | 15 |
| 1979-05-26 | vs CIN | 47 | L 1-3 | 22-25 | 4 | 39,533 | Don Sutton | Fred Norman | Fred Norman | Don Sutton | | 211 | 198 | 13 |
| 1979-05-27 | vs CIN | 48 | W 8-7 | 23-25 | 4 | 44,150 | Andy Messersmith | Bill Bonham | Lerrin LaGrow | Pedro Borbon | Bob Welch | 219 | 205 | 14 |
| 1979-05-28 | vs CIN | 49 | L 2-3 | 23-26 | 4 | 49,114 | Doug Rau | Mike LaCoss | Dave Tomlin | Charlie Hough | Tom Hume | 221 | 208 | 13 |
| 1979-05-29 | vs SFN | 50 | W 6-5 | 24-26 | 4 | 35,845 | Burt Hooton | Bob Knepper | Terry Forster | Gary Lavelle | | 227 | 213 | 14 |
| 1979-05-30 | vs SFN | 51 | W 6-5 | 25-26 | 4 | 42,819 | Rick Sutcliffe | John Curtis | Jerry Reuss | Gary Lavelle | Lerrin LaGrow | 233 | 218 | 15 |
| 1979-05-31 | vs SFN | 52 | W 12-10 | 26-26 | 3 | 36,288 | Don Sutton | Vida Blue | Don Sutton | Vida Blue | Bob Welch | 245 | 228 | 17 |
| 1979-06-01 | @ SLN | 53 | L 7-8 | 26-27 | 3 | 26,687 | Andy Messersmith | John Denny | Buddy Schultz | Bob Welch | | 252 | 236 | 16 |
| 1979-06-02 | @ SLN | 54 | L 5-12 | 26-28 | 4 | 33,452 | Doug Rau | Bob Forsch | Bob Forsch | Doug Rau | | 257 | 248 | 9 |
| 1979-06-03 | @ SLN | 55 | L 4-6 | 26-29 | 4 | 31,217 | Burt Hooton | Pete Vuckovich | Pete Vuckovich | Burt Hooton | | 261 | 254 | 7 |
| 1979-06-04 | @ PIT | 56 | W 4-2 | 27-29 | 3 | 14,727 | Rick Sutcliffe | Jim Rooker | Rick Sutcliffe | Jim Rooker | | 265 | 256 | 9 |
| 1979-06-05 | @ PIT | 57 | L 1-3 | 27-30 | 3 | 11,088 | Don Sutton | Bert Blyleven | Bert Blyleven | Don Sutton | Kent Tekulve | 266 | 259 | 7 |
| 1979-06-06 | @ PIT | 58 | L 4-5 | 27-31 | 3 | 16,666 | Jerry Reuss | Ed Whitson | Enrique Romo | Bob Welch | Kent Tekulve | 270 | 264 | 6 |
| 1979-06-08 | @ CHN | 59 | W 11-4 | 28-31 | 3 | 21,162 | Burt Hooton | Mike Krukow | Burt Hooton | Mike Krukow | | 281 | 268 | 13 |
| 1979-06-09 | @ CHN | 60 | L 3-5 | 28-32 | 4 | 25,683 | Rick Sutcliffe | Dennis Lamp | Dennis Lamp | Rick Sutcliffe | Dick Tidrow | 284 | 273 | 11 |
| 1979-06-10 | @ CHN | 61 | L 3-10 | 28-33 | 4 | 24,088 | Don Sutton | Rick Reuschel | Rick Reuschel | Don Sutton | Lynn McGlothen | 287 | 283 | 4 |
| 1979-06-11 | vs SLN | 62 | L 7-9 | 28-34 | 4 | 32,159 | Jerry Reuss | Bob Sykes | Tom Bruno | Lerrin LaGrow | | 294 | 292 | 2 |
| 1979-06-12 | vs SLN | 63 | W 9-3 | 29-34 | 4 | 35,651 | Burt Hooton | John Denny | Burt Hooton | John Denny | | 303 | 295 | 8 |
| 1979-06-13 | vs SLN | 64 | W 9-8 | 30-34 | 4 | 42,235 | Rick Sutcliffe | Bob Forsch | Rick Sutcliffe | Bob Forsch | Terry Forster | 312 | 303 | 9 |
| 1979-06-15 | vs PIT | 65 | L 2-6 | 30-35 | 4 | 50,299 | Don Sutton | Bert Blyleven | Bert Blyleven | Don Sutton | Kent Tekulve | 314 | 309 | 5 |
| 1979-06-16 | vs PIT | 66 | L 3-6 | 30-36 | 4 | 49,448 | Bob Welch | Don Robinson | Don Robinson | Bob Welch | | 317 | 315 | 2 |
| 1979-06-17 | vs PIT | 67 | L 1-5 | 30-37 | 4 | 45,835 | Jerry Reuss | Ed Whitson | Ed Whitson | Jerry Reuss | Kent Tekulve | 318 | 320 | -2 |
| 1979-06-18 | vs CHN | 68 | W 7-3 | 31-37 | 4 | 27,569 | Burt Hooton | Dennis Lamp | Burt Hooton | Dennis Lamp | | 325 | 323 | 2 |
| 1979-06-19 | vs CHN | 69 | L 4-7 | 31-38 | 4 | 38,605 | Rick Sutcliffe | Rick Reuschel | Dick Tidrow | Rick Sutcliffe | Bruce Sutter | 329 | 330 | -1 |
| 1979-06-21 | @ ATL | 70 | W 6-4 | 32-38 | 4 | 10,717 | Don Sutton | Mickey Mahler | Don Sutton | Mickey Mahler | Dave Patterson | 335 | 334 | 1 |
| 1979-06-22 | @ ATL | 71 | L 2-3 | 32-39 | 4 | 15,528 | Bob Welch | Tony Brizzolara | Tony Brizzolara | Bob Welch | Gene Garber | 337 | 337 | 0 |
| 1979-06-23 | @ ATL | 72 | L 3-7 | 32-40 | 4 | 16,347 | Jerry Reuss | Phil Niekro | Phil Niekro | Jerry Reuss | | 340 | 344 | -4 |
| 1979-06-24 | @ ATL | 73 | L 2-4 | 32-41 | 4 | 14,305 | Burt Hooton | Rick Matula | Rick Matula | Burt Hooton | | 342 | 348 | -6 |
| 1979-06-25 | vs SDN | 74 | W 4-3 | 33-41 | 4 | 29,142 | Rick Sutcliffe | Gaylord Perry | Ken Brett | Rollie Fingers | | 346 | 351 | -5 |
| 1979-06-26 | vs SDN | 75 | L 1-5 | 33-42 | 4 | 35,001 | Don Sutton | Bob Shirley | Bob Shirley | Don Sutton | | 347 | 356 | -9 |
| 1979-06-27 | vs CIN | 76 | L 1-9 | 33-43 | 5 | 40,768 | Jerry Reuss | Fred Norman | Fred Norman | Jerry Reuss | | 348 | 365 | -17 |
| 1979-06-28 | vs CIN | 77 | L 1-2 | 33-44 | 5 | 38,873 | Burt Hooton | Tom Hume | Tom Hume | Burt Hooton | Doug Bair | 349 | 367 | -18 |
| 1979-06-29 | vs ATL | 78 | L 2-5 | 33-45 | 5 | 35,359 | Rick Sutcliffe | Rick Matula | Rick Matula | Rick Sutcliffe | Gene Garber | 351 | 372 | -21 |
| 1979-06-30 | vs ATL | 79 | L 4-7 | 33-46 | 5 | 38,760 | Don Sutton | Eddie Solomon | Gene Garber | Terry Forster | | 355 | 379 | -24 |
| 1979-07-01 | vs ATL | 80 | L 1-2 | 33-47 | 5 | 32,196 | Jerry Reuss | Phil Niekro | Phil Niekro | Ken Brett | Joey McLaughlin | 356 | 381 | -25 |
| 1979-07-02 | @ SDN | 81 | W 6-3 | 34-47 | 5 | 13,535 | Burt Hooton | John D'Acquisto | Ken Brett | Bob Owchinko | | 362 | 384 | -22 |
| 1979-07-03 | @ SDN | 82 | L 2-3 | 34-48 | 5 | 24,674 | Rick Sutcliffe | Gaylord Perry | Gaylord Perry | Rick Sutcliffe | | 364 | 387 | -23 |
| 1979-07-04 | @ SDN | 83 | L 0-6 | 34-49 | 6 | 45,481 | Don Sutton | Bob Shirley | Bob Shirley | Don Sutton | | 364 | 393 | -29 |
| 1979-07-06 | @ MON | 84 | L 4-6 | 34-50 | 6 | 37,460 | Jerry Reuss | Dan Schatzeder | Dan Schatzeder | Jerry Reuss | Elias Sosa | 368 | 399 | -31 |
| 1979-07-07 | @ MON | 85 | L 1-2 | 34-51 | 6 | 46,502 | Burt Hooton | Steve Rogers | Steve Rogers | Burt Hooton | | 369 | 401 | -32 |
| 1979-07-08 | @ MON | 86 | W 8-6 | 35-51 | 6 | 46,601 | Rick Sutcliffe | Ross Grimsley | Rick Sutcliffe | Ross Grimsley | Lerrin LaGrow | 377 | 407 | -30 |
| 1979-07-09 | @ MON | 87 | L 0-3 | 35-52 | 6 | 30,930 | Don Sutton | Bill Lee | Bill Lee | Don Sutton | | 377 | 410 | -33 |
| 1979-07-10 | @ NYN | 88 | W 7-4 | 36-52 | 6 | 12,218 | Bob Welch | Craig Swan | Charlie Hough | Craig Swan | Dave Patterson | 384 | 414 | -30 |
| 1979-07-11 | @ NYN | 89 | L 3-4 | 36-53 | 6 | 11,401 | Jerry Reuss | Pete Falcone | Neil Allen | Dennis Lewallyn | | 387 | 418 | -31 |
| 1979-07-12 | @ NYN | 90 | L 5-12 | 36-54 | 6 | 13,218 | Burt Hooton | Dock Ellis | Dock Ellis | Burt Hooton | | 392 | 430 | -38 |
| 1979-07-13 | @ PHI | 91 | L 2-3 | 36-55 | 6 | 46,542 | Rick Sutcliffe | Dickie Noles | Dickie Noles | Rick Sutcliffe | Tug McGraw | 394 | 433 | -39 |
| 1979-07-14 | @ PHI | 92 | L 7-10 | 36-56 | 6 | 40,602 | Don Sutton | Nino Espinosa | Nino Espinosa | Don Sutton | Tug McGraw | 401 | 443 | -42 |
| 1979-07-15 | @ PHI | 93 | L 3-10 | 36-57 | 6 | 47,315 | Bob Welch | Randy Lerch | Randy Lerch | Bob Welch | Rawly Eastwick | 404 | 453 | -49 |
| 1979-07-19 | vs MON | 94 | W 7-3 | 37-57 | 6 | 29,046 | Burt Hooton | Dan Schatzeder | Burt Hooton | Dan Schatzeder | | 411 | 456 | -45 |
| 1979-07-20 | vs MON | 95 | W 6-5 | 38-57 | 6 | 48,825 | Rick Sutcliffe | Steve Rogers | Dave Patterson | Woodie Fryman | | 417 | 461 | -44 |
| 1979-07-21 | vs MON | 96 | L 2-7 | 38-58 | 6 | 30,143 | Don Sutton | Bill Lee | Bill Lee | Don Sutton | | 419 | 468 | -49 |
| 1979-07-22 | vs NYN | 97 | W 4-3 | 39-58 | 6 | 34,198 | Charlie Hough | Dock Ellis | Lerrin LaGrow | Ed Glynn | | 423 | 471 | -48 |
| 1979-07-23 | vs NYN | 98 | W 3-1 | 40-58 | 6 | 25,351 | Jerry Reuss | Pete Falcone | Jerry Reuss | Pete Falcone | | 426 | 472 | -46 |
| 1979-07-24 | vs PHI | 99 | W 15-3 | 41-58 | 5 | 39,336 | Burt Hooton | Randy Lerch | Burt Hooton | Randy Lerch | | 441 | 475 | -34 |
| 1979-07-25 | vs PHI | 100 | W 16-8 | 42-58 | 5 | 34,370 | Rick Sutcliffe | Dick Ruthven | Rick Sutcliffe | Dick Ruthven | | 457 | 483 | -26 |
| 1979-07-26 | @ HOU | 101 | W 6-5 | 43-58 | 5 | 26,834 | Don Sutton | Joaquin Andujar | Joe Beckwith | Joaquin Andujar | Terry Forster | 463 | 488 | -25 |
| 1979-07-27 | @ HOU | 102 | W 11-7 | 44-58 | 5 | 39,071 | Charlie Hough | Joe Niekro | Charlie Hough | Joe Niekro | | 474 | 495 | -21 |
| 1979-07-28 | @ HOU | 103 | L 2-5 | 44-59 | 5 | 39,747 | Jerry Reuss | Ken Forsch | Ken Forsch | Jerry Reuss | | 476 | 500 | -24 |
| 1979-07-29 | @ HOU | 104 | L 3-4 | 44-60 | 5 | 46,754 | Burt Hooton | J.R. Richard | J.R. Richard | Terry Forster | | 479 | 504 | -25 |
| 1979-07-30 | @ CIN | 105 | L 4-9 | 44-61 | 5 | 34,562 | Rick Sutcliffe | Tom Seaver | Doug Bair | Ken Brett | | 483 | 513 | -30 |
| 1979-07-31 | @ CIN | 106 | W 7-6 | 45-61 | 5 | 32,649 | Don Sutton | Paul Moskau | Don Sutton | Paul Moskau | Dave Patterson | 490 | 519 | -29 |
| 1979-08-01 | @ CIN | 107 | L 5-10 | 45-62 | 5 | 28,409 | Charlie Hough | Mike LaCoss | Mike LaCoss | Charlie Hough | Tom Hume | 495 | 529 | -34 |
| 1979-08-03 | vs SFN | 108 | W 11-3 | 46-62 | 5 | 44,275 | Burt Hooton | John Curtis | Burt Hooton | John Curtis | | 506 | 532 | -26 |
| 1979-08-04 | vs SFN | 109 | W 4-3 | 47-62 | 5 | 44,818 | Rick Sutcliffe | John Montefusco | Dave Patterson | Gary Lavelle | | 510 | 535 | -25 |
| 1979-08-05 | vs SFN | 110 | W 8-1 | 48-62 | 5 | 38,962 | Don Sutton | Bob Knepper | Don Sutton | Bob Knepper | | 518 | 536 | -18 |
| 1979-08-06 | vs SFN | 111 | L 1-7 | 48-63 | 5 | 30,453 | Charlie Hough | Ed Whitson | Ed Whitson | Charlie Hough | | 519 | 543 | -24 |
| 1979-08-07 | vs HOU | 112 | W 10-8 | 49-63 | 5 | 34,538 | Jerry Reuss | Ken Forsch | Ken Brett | Joe Sambito | Dave Patterson | 529 | 551 | -22 |
| 1979-08-08 | vs HOU | 113 | L 1-4 | 49-64 | 5 | 41,584 | Burt Hooton | J.R. Richard | J.R. Richard | Burt Hooton | | 530 | 555 | -25 |
| 1979-08-09 | vs HOU | 114 | W 4-3 | 50-64 | 5 | 30,973 | Rick Sutcliffe | Joaquin Andujar | Rick Sutcliffe | Joaquin Andujar | Joe Beckwith | 534 | 558 | -24 |
| 1979-08-10 | @ SFN | 115 | W 9-0 | 51-64 | 5 | 31,530 | Don Sutton | Bob Knepper | Don Sutton | Bob Knepper | | 543 | 558 | -15 |
| 1979-08-11 | @ SFN | 116 | W 7-4 | 52-64 | 4 | 42,477 | Charlie Hough | Ed Whitson | Charlie Hough | Ed Whitson | Dave Patterson | 550 | 562 | -12 |
| 1979-08-12 | @ SFN | 117 | L 1-4 | 52-65 | 5 | 39,914 | Jerry Reuss | Vida Blue | Vida Blue | Jerry Reuss | | 551 | 566 | -15 |
| 1979-08-14 | @ SLN | 118 | W 9-0 | 53-65 | 4 | 21,126 | Burt Hooton | John Denny | Burt Hooton | John Denny | | 560 | 566 | -6 |
| 1979-08-15 | @ SLN | 119 | W 6-5 | 54-65 | 4 | 29,369 | Rick Sutcliffe | Silvio Martinez | Rick Sutcliffe | Silvio Martinez | Ken Brett | 566 | 571 | -5 |
| 1979-08-16 | @ SLN | 120 | W 4-2 | 55-65 | 4 | 19,551 | Don Sutton | Bob Forsch | Bobby Castillo | George Frazier | | 570 | 573 | -3 |
| 1979-08-17 | @ PIT | 121 | W 7-6 | 56-65 | 4 | 22,416 | Charlie Hough | Jim Bibby | Dave Patterson | Jim Bibby | Bobby Castillo | 577 | 579 | -2 |
| 1979-08-18 | @ PIT | 122 | W 5-1 | 57-65 | 3 | 40,238 | Jerry Reuss | Don Robinson | Jerry Reuss | Don Robinson | | 582 | 580 | 2 |
| 1979-08-19 | @ PIT | 123 | L 0-2 | 57-66 | 3 | 28,382 | Burt Hooton | John Candelaria | Kent Tekulve | Burt Hooton | | 582 | 582 | 0 |
| 1979-08-20 | @ CHN | 124 | L 1-2 | 57-67 | 3 | 25,285 | Rick Sutcliffe | Lynn McGlothen | Lynn McGlothen | Rick Sutcliffe | Bruce Sutter | 583 | 584 | -1 |
| 1979-08-21 | @ CHN | 125 | W 4-2 | 58-67 | 3 | 34,745 | Don Sutton | Bill Caudill | Don Sutton | Bill Caudill | Bobby Castillo | 587 | 586 | 1 |
| 1979-08-22 | @ CHN | 126 | W 7-2 | 59-67 | 3 | 31,249 | Charlie Hough | Mike Krukow | Charlie Hough | Mike Krukow | Bobby Castillo | 594 | 588 | 6 |
| 1979-08-24 | vs SLN | 127 | L 5-12 | 59-68 | 3 | 40,478 | Jerry Reuss | Pete Vuckovich | Pete Vuckovich | Jerry Reuss | | 599 | 600 | -1 |
| 1979-08-25 | vs SLN | 128 | L 4-5 | 59-69 | 3 | 47,244 | Burt Hooton | John Denny | Roy Thomas | Ken Brett | | 603 | 605 | -2 |
| 1979-08-26 | vs SLN | 129 | W 4-1 | 60-69 | 3 | 29,461 | Rick Sutcliffe | Silvio Martinez | Rick Sutcliffe | Silvio Martinez | Bobby Castillo | 607 | 606 | 1 |
| 1979-08-27 | vs PIT | 130 | W 4-2 | 61-69 | 3 | 35,705 | Don Sutton | Jim Bibby | Ken Brett | Kent Tekulve | | 611 | 608 | 3 |
| 1979-08-28 | vs PIT | 131 | L 1-4 | 61-70 | 3 | 31,587 | Charlie Hough | John Candelaria | John Candelaria | Charlie Hough | | 612 | 612 | 0 |
| 1979-08-29 | vs PIT | 132 | L 1-4 | 61-71 | 3 | 32,816 | Jerry Reuss | Bert Blyleven | Bert Blyleven | Jerry Reuss | Kent Tekulve | 613 | 616 | -3 |
| 1979-08-30 | vs CHN | 133 | L 1-4 | 61-72 | 3 | 28,406 | Burt Hooton | Dennis Lamp | Dennis Lamp | Burt Hooton | Bruce Sutter | 614 | 620 | -6 |
| 1979-08-31 | vs CHN | 134 | W 6-4 | 62-72 | 3 | 35,648 | Rick Sutcliffe | Bill Caudill | Rick Sutcliffe | Bill Caudill | Bobby Castillo | 620 | 624 | -4 |
| 1979-09-01 | vs CHN | 135 | W 5-4 | 63-72 | 3 | 31,586 | Don Sutton | Rick Reuschel | Don Sutton | Rick Reuschel | | 625 | 628 | -3 |
| 1979-09-02 | vs CHN | 136 | W 6-2 | 64-72 | 3 | 27,092 | Charlie Hough | Lynn McGlothen | Lerrin LaGrow | Bruce Sutter | | 631 | 630 | 1 |
| 1979-09-03 | @ HOU | 137 | W 1-0 | 65-72 | 3 | 19,280 | Jerry Reuss | Joe Niekro | Jerry Reuss | Joe Niekro | | 632 | 630 | 2 |
| 1979-09-04 | @ HOU | 138 | L 4-9 | 65-73 | 3 | 14,404 | Burt Hooton | Rick Williams | Rick Williams | Joe Beckwith | Joaquin Andujar | 636 | 639 | -3 |
| 1979-09-05 | @ ATL | 139 | W 5-3 | 66-73 | 3 | 2,606 | Rick Sutcliffe | Phil Niekro | Lerrin LaGrow | Gene Garber | Dave Patterson | 641 | 642 | -1 |
| 1979-09-06 | @ ATL | 140 | L 2-6 | 66-74 | 3 | 2,583 | Don Sutton | Preston Hanna | Preston Hanna | Don Sutton | Joey McLaughlin | 643 | 648 | -5 |
| 1979-09-07 | @ CIN | 141 | W 6-5 | 67-74 | 3 | 33,937 | Charlie Hough | Mike LaCoss | Bobby Castillo | Tom Hume | Gerry Hannahs | 649 | 653 | -4 |
| 1979-09-08 | @ CIN | 142 | L 1-4 | 67-75 | 3 | 40,345 | Jerry Reuss | Bill Bonham | Bill Bonham | Jerry Reuss | Tom Hume | 650 | 657 | -7 |
| 1979-09-09 | @ CIN | 143 | W 3-1 | 68-75 | 3 | 39,066 | Rick Sutcliffe | Fred Norman | Rick Sutcliffe | Fred Norman | Lerrin LaGrow | 653 | 658 | -5 |
| 1979-09-11 | vs SDN | 144 | L 1-3 | 68-76 | 3 | 20,870 | Don Sutton | Bob Owchinko | Bob Owchinko | Don Sutton | Steve Mura | 654 | 661 | -7 |
| 1979-09-12 | vs SDN | 145 | W 5-2 | 69-76 | 3 | 20,600 | Charlie Hough | Eric Rasmussen | Charlie Hough | Eric Rasmussen | Bobby Castillo | 659 | 663 | -4 |
| 1979-09-13 | vs SDN | 146 | W 8-6 | 70-76 | 3 | 21,972 | Jerry Reuss | Bob Shirley | Jerry Reuss | Bob Shirley | Ken Brett | 667 | 669 | -2 |
| 1979-09-14 | vs CIN | 147 | W 2-0 | 71-76 | 3 | 37,514 | Rick Sutcliffe | Bill Bonham | Rick Sutcliffe | Bill Bonham | | 669 | 669 | 0 |
| 1979-09-15 | vs CIN | 148 | L 1-2 | 71-77 | 3 | 27,892 | Bob Welch | Fred Norman | Mario Soto | Joe Beckwith | | 670 | 671 | -1 |
| 1979-09-16 | vs CIN | 149 | L 0-2 | 71-78 | 3 | 28,322 | Don Sutton | Tom Seaver | Tom Seaver | Don Sutton | | 670 | 673 | -3 |
| 1979-09-17 | vs ATL | 150 | W 9-4 | 72-78 | 3 | 16,700 | Charlie Hough | Phil Niekro | Charlie Hough | Phil Niekro | | 679 | 677 | 2 |
| 1979-09-18 | vs ATL | 151 | W 6-1 | 73-78 | 3 | 21,591 | Jerry Reuss | Eddie Solomon | Jerry Reuss | Eddie Solomon | | 685 | 678 | 7 |
| 1979-09-19 | vs SFN | 152 | W 7-2 | 74-78 | 3 | 20,827 | Rick Sutcliffe | Ed Halicki | Rick Sutcliffe | Ed Halicki | | 692 | 680 | 12 |
| 1979-09-20 | vs SFN | 153 | W 3-0 | 75-78 | 3 | 24,522 | Bob Welch | Bob Knepper | Bob Welch | Bob Knepper | Joe Beckwith | 695 | 680 | 15 |
| 1979-09-21 | @ SDN | 154 | L 1-3 | 75-79 | 3 | 16,514 | Gerry Hannahs | Juan Eichelberger | Juan Eichelberger | Gerry Hannahs | | 696 | 683 | 13 |
| 1979-09-22 | @ SDN | 155 | L 8-10 | 75-80 | 3 | 16,299 | Charlie Hough | Bob Owchinko | Steve Mura | Dave Patterson | Mark Lee | 704 | 693 | 11 |
| 1979-09-23 | @ SDN | 156 | W 5-2 | 76-80 | 3 | 15,171 | Jerry Reuss | Eric Rasmussen | Lerrin LaGrow | Steve Mura | Don Sutton | 709 | 695 | 14 |
| 1979-09-25 | @ SFN | 157 | W 11-2 | 77-80 | 3 | 8,694 | Rick Sutcliffe | Ed Halicki | Rick Sutcliffe | Ed Halicki | | 720 | 697 | 23 |
| 1979-09-26 | @ SFN | 158 | W 8-4 | 78-80 | 3 | 10,791 | Bob Welch | Tom Griffin | Dave Patterson | Tom Griffin | Lerrin LaGrow | 728 | 701 | 27 |
| 1979-09-27 | @ SFN | 159 | L 3-5 | 78-81 | 3 | 8,381 | Gerry Hannahs | Vida Blue | Vida Blue | Gerry Hannahs | Greg Minton | 731 | 706 | 25 |
| 1979-09-28 | vs HOU | 160 | W 6-5 | 79-81 | 3 | 27,719 | Charlie Hough | Ken Forsch | Charlie Hough | Vern Ruhle | Bobby Castillo | 737 | 711 | 26 |
| 1979-09-29 | vs HOU | 161 | L 0-3 | 79-82 | 3 | 20,647 | Jerry Reuss | J.R. Richard | J.R. Richard | Jerry Reuss | Joe Sambito | 737 | 714 | 23 |
| 1979-09-30 | vs HOU | 162 | L 2-3 | 79-83 | 3 | 46,741 | Rick Sutcliffe | Joe Niekro | Joe Niekro | Rick Sutcliffe | Joe Sambito | 739 | 717 | 22 |