| 1979-04-05 | vs TOR | 1 | W 11-2 | 1-0 | 1 | 37,754 | Dennis Leonard | Tom Underwood | Dennis Leonard | Tom Underwood | Steve Mingori | 11 | 2 | 9 |
| 1979-04-07 | vs TOR | 2 | W 7-4 | 2-0 | 1 | 21,850 | Larry Gura | Jim Clancy | Larry Gura | Jim Clancy | Al Hrabosky | 18 | 6 | 12 |
| 1979-04-08 | vs TOR | 3 | W 8-3 | 3-0 | 1 | 23,477 | Paul Splittorff | Mark Lemongello | Paul Splittorff | Mark Lemongello | | 26 | 9 | 17 |
| 1979-04-09 | vs DET | 4 | L 3-7 | 3-1 | 3 | 18,429 | Rich Gale | Milt Wilcox | Milt Wilcox | Rich Gale | John Hiller | 29 | 16 | 13 |
| 1979-04-11 | vs DET | 5 | W 10-3 | 4-1 | 2 | 14,833 | Larry Gura | Jack Billingham | Eduardo Rodriguez | Bruce Taylor | | 39 | 19 | 20 |
| 1979-04-13 | @ TOR | 6 | L 1-4 | 4-2 | 3 | 40,035 | Paul Splittorff | Jim Clancy | Jim Clancy | Paul Splittorff | | 40 | 23 | 17 |
| 1979-04-14 | @ TOR | 7 | L 6-8 | 4-3 | 4 | 11,683 | Dennis Leonard | Mark Lemongello | Dave Freisleben | Dennis Leonard | | 46 | 31 | 15 |
| 1979-04-15 | @ TOR | 8 | W 12-10 | 5-3 | 4 | 12,287 | Rich Gale | Phil Huffman | Eduardo Rodriguez | Tom Murphy | Al Hrabosky | 58 | 41 | 17 |
| 1979-04-16 | @ DET | 9 | L 4-10 | 5-4 | 4 | 9,457 | Larry Gura | Jack Billingham | Jack Billingham | Larry Gura | Steve Baker | 62 | 51 | 11 |
| 1979-04-17 | @ DET | 10 | L 3-6 | 5-5 | 4 | 15,275 | Paul Splittorff | Dave Rozema | John Hiller | Paul Splittorff | | 65 | 57 | 8 |
| 1979-04-20 | @ BOS | 11 | L 2-9 | 5-6 | 5 | 20,925 | Dennis Leonard | Dennis Eckersley | Andy Hassler | Dennis Leonard | | 67 | 66 | 1 |
| 1979-04-21 | @ BOS | 12 | L 4-10 | 5-7 | 5 | 34,332 | Larry Gura | Bob Stanley | Bob Stanley | Larry Gura | Tom Burgmeier | 71 | 76 | -5 |
| 1979-04-22 | @ BOS | 13 | L 0-6 | 5-8 | 5 | 32,089 | Rich Gale | Mike Torrez | Mike Torrez | Rich Gale | | 71 | 82 | -11 |
| 1979-04-23 | vs CHA | 14 | W 4-3 | 6-8 | 5 | 17,864 | Paul Splittorff | Rich Wortham | Paul Splittorff | Rich Wortham | Al Hrabosky | 75 | 85 | -10 |
| 1979-04-24 | vs CHA | 15 | W 5-0 | 7-8 | 4 | 16,335 | Dennis Leonard | Lerrin LaGrow | Dennis Leonard | Lerrin LaGrow | | 80 | 85 | -5 |
| 1979-04-25 | vs CHA | 16 | W 7-6 | 8-8 | 4 | 13,957 | Larry Gura | Ken Kravec | Al Hrabosky | Mike Proly | | 87 | 91 | -4 |
| 1979-04-26 | vs CLE | 17 | W 5-4 | 9-8 | 4 | 15,122 | Rich Gale | Mike Paxton | Al Hrabosky | Dan Spillner | | 92 | 95 | -3 |
| 1979-04-27 | vs CLE | 18 | W 15-7 | 10-8 | 4 | 17,411 | Paul Splittorff | Wayne Garland | Paul Splittorff | Wayne Garland | Eduardo Rodriguez | 107 | 102 | 5 |
| 1979-04-28 | vs CLE | 19 | W 7-2 | 11-8 | 4 | 27,167 | Dennis Leonard | Rick Waits | Dennis Leonard | Rick Waits | | 114 | 104 | 10 |
| 1979-04-29 | vs CLE | 20 | L 4-5 | 11-9 | 4 | 26,184 | Larry Gura | Rick Wise | Rick Wise | Larry Gura | Sid Monge | 118 | 109 | 9 |
| 1979-04-30 | vs TEX | 21 | L 7-8 | 11-10 | 4 | 23,634 | Rich Gale | Fergie Jenkins | Jim Kern | Steve Busby | Sparky Lyle | 125 | 117 | 8 |
| 1979-05-01 | vs TEX | 22 | W 9-3 | 12-10 | 4 | 20,767 | Paul Splittorff | Jon Matlack | Paul Splittorff | Jon Matlack | Marty Pattin | 134 | 120 | 14 |
| 1979-05-02 | vs TEX | 23 | L 2-3 | 12-11 | 4 | 20,155 | Dennis Leonard | Steve Comer | Steve Comer | Dennis Leonard | Sparky Lyle | 136 | 123 | 13 |
| 1979-05-04 | @ CLE | 24 | W 5-4 | 13-11 | 4 | 4,056 | Larry Gura | Rick Waits | Al Hrabosky | Sid Monge | | 141 | 127 | 14 |
| 1979-05-05 | @ CLE | 25 | W 3-2 | 14-11 | 4 | 9,529 | Rich Gale | Rick Wise | Rich Gale | Rick Wise | Al Hrabosky | 144 | 129 | 15 |
| 1979-05-06 | @ CLE | 26 | L 4-5 | 14-12 | 4 | 16,352 | Steve Busby | Mike Paxton | Mike Paxton | Al Hrabosky | | 148 | 134 | 14 |
| 1979-05-07 | @ TEX | 27 | W 10-6 | 15-12 | 3 | 14,242 | Dennis Leonard | Steve Comer | Eduardo Rodriguez | Doc Medich | Marty Pattin | 158 | 140 | 18 |
| 1979-05-08 | @ TEX | 28 | L 7-8 | 15-13 | 4 | 14,400 | Larry Gura | Ed Farmer | Jim Kern | Larry Gura | | 165 | 148 | 17 |
| 1979-05-09 | @ TEX | 29 | W 4-3 | 16-13 | 3 | 18,324 | Rich Gale | Fergie Jenkins | Rich Gale | Fergie Jenkins | Renie Martin | 169 | 151 | 18 |
| 1979-05-10 | @ CHA | 30 | L 2-5 | 16-14 | 4 | 13,801 | Paul Splittorff | Francisco Barrios | Steve Trout | Paul Splittorff | | 171 | 156 | 15 |
| 1979-05-11 | @ CHA | 31 | L 3-5 | 16-15 | 4 | 20,973 | Steve Busby | Ken Kravec | Ken Kravec | Steve Busby | Randy Scarbery | 174 | 161 | 13 |
| 1979-05-12 | @ CHA | 32 | W 5-4 | 17-15 | 4 | 15,470 | Marty Pattin | Rich Hinton | Marty Pattin | Rich Hinton | Renie Martin | 179 | 165 | 14 |
| 1979-05-13 | @ CHA | 33 | W 14-5 | 18-15 | 4 | 20,100 | Eduardo Rodriguez | Rich Wortham | Eduardo Rodriguez | Rich Wortham | | 193 | 170 | 23 |
| 1979-05-14 | @ SEA | 34 | W 1-0 | 19-15 | 3 | 5,113 | Rich Gale | Floyd Bannister | Rich Gale | Floyd Bannister | | 194 | 170 | 24 |
| 1979-05-15 | @ SEA | 35 | W 7-4 | 20-16 | 4 | 0 | Paul Splittorff | Glenn Abbott | Paul Splittorff | Glenn Abbott | Renie Martin | 201 | 174 | 27 |
| 1979-05-15 | @ SEA | 36 | L 2-6 | 20-16 | 4 | 6,356 | Larry Gura | Mike Parrott | Byron McLaughlin | Larry Gura | | 203 | 180 | 23 |
| 1979-05-16 | @ SEA | 37 | W 4-3 | 21-16 | 4 | 4,819 | Steve Busby | Odell Jones | Steve Busby | Odell Jones | | 207 | 183 | 24 |
| 1979-05-17 | vs MIN | 38 | L 6-7 | 21-17 | 4 | 21,437 | Dennis Leonard | Jerry Koosman | Jerry Koosman | Dennis Leonard | Mike Marshall | 213 | 190 | 23 |
| 1979-05-18 | vs MIN | 39 | L 6-10 | 21-18 | 4 | 21,475 | Marty Pattin | Dave Goltz | Mike Marshall | Renie Martin | | 219 | 200 | 19 |
| 1979-05-20 | vs MIN | 40 | W 5-1 | 22-18 | 4 | 39,661 | Paul Splittorff | Roger Erickson | Paul Splittorff | Roger Erickson | | 224 | 201 | 23 |
| 1979-05-21 | vs SEA | 41 | L 7-12 | 22-19 | 4 | 22,940 | Rich Gale | Glenn Abbott | Glenn Abbott | Rich Gale | Shane Rawley | 231 | 213 | 18 |
| 1979-05-22 | vs SEA | 42 | L 11-12 | 22-20 | 4 | 18,967 | Steve Busby | Odell Jones | Shane Rawley | Al Hrabosky | | 242 | 225 | 17 |
| 1979-05-24 | vs SEA | 43 | W 5-4 | 23-20 | 4 | 19,428 | Dennis Leonard | Floyd Bannister | Dennis Leonard | Odell Jones | | 247 | 229 | 18 |
| 1979-05-25 | @ MIN | 44 | W 4-3 | 24-20 | 4 | 9,606 | Paul Splittorff | Roger Erickson | Paul Splittorff | Mike Marshall | Al Hrabosky | 251 | 232 | 19 |
| 1979-05-26 | @ MIN | 45 | W 7-4 | 25-20 | 4 | 9,023 | Rich Gale | Paul Hartzell | Rich Gale | Paul Hartzell | Al Hrabosky | 258 | 236 | 22 |
| 1979-05-27 | @ MIN | 46 | W 2-1 | 26-20 | 4 | 35,148 | Steve Busby | Jerry Koosman | Steve Busby | Jerry Koosman | | 260 | 237 | 23 |
| 1979-05-28 | vs BAL | 47 | W 5-4 | 27-20 | 4 | 34,677 | Marty Pattin | Dennis Martinez | Larry Gura | Sammy Stewart | | 265 | 241 | 24 |
| 1979-05-29 | vs BAL | 48 | L 1-8 | 27-21 | 4 | 22,731 | Paul Splittorff | Jim Palmer | Jim Palmer | Paul Splittorff | | 266 | 249 | 17 |
| 1979-05-30 | vs BAL | 49 | W 2-1 | 28-21 | 4 | 20,838 | Rich Gale | Mike Flanagan | Rich Gale | Mike Flanagan | Al Hrabosky | 268 | 250 | 18 |
| 1979-06-01 | vs MIL | 50 | L 4-5 | 28-22 | 4 | 32,469 | Larry Gura | Lary Sorensen | Lary Sorensen | Renie Martin | Jerry Augustine | 272 | 255 | 17 |
| 1979-06-02 | vs MIL | 51 | W 4-3 | 29-22 | 4 | 32,795 | Paul Splittorff | Bill Travers | Paul Splittorff | Reggie Cleveland | | 276 | 258 | 18 |
| 1979-06-03 | vs MIL | 52 | W 6-1 | 30-22 | 3 | 37,942 | Marty Pattin | Moose Haas | Marty Pattin | Moose Haas | | 282 | 259 | 23 |
| 1979-06-04 | @ NYA | 53 | L 3-8 | 30-23 | 3 | 30,164 | Rich Gale | Tommy John | Tommy John | Rich Gale | | 285 | 267 | 18 |
| 1979-06-05 | @ NYA | 54 | W 3-1 | 31-23 | 2 | 24,968 | Larry Gura | Luis Tiant | Larry Gura | Luis Tiant | | 288 | 268 | 20 |
| 1979-06-06 | @ BAL | 55 | L 0-3 | 31-24 | 2 | 14,314 | Paul Splittorff | Dennis Martinez | Dennis Martinez | Paul Splittorff | | 288 | 271 | 17 |
| 1979-06-07 | @ BAL | 56 | L 1-3 | 31-25 | 4 | 13,724 | Steve Busby | Sammy Stewart | Sammy Stewart | Renie Martin | | 289 | 274 | 15 |
| 1979-06-08 | vs NYA | 57 | L 10-11 | 31-26 | 4 | 35,589 | Rich Gale | Ed Figueroa | Ken Clay | Eduardo Rodriguez | | 299 | 285 | 14 |
| 1979-06-09 | vs NYA | 58 | W 9-8 | 32-26 | 2 | 38,025 | Larry Gura | Tommy John | Marty Pattin | Ken Clay | | 308 | 293 | 15 |
| 1979-06-10 | vs NYA | 59 | L 4-10 | 32-27 | 2 | 41,095 | Steve Mingori | Luis Tiant | Luis Tiant | Steve Mingori | | 312 | 303 | 9 |
| 1979-06-11 | vs BOS | 60 | L 0-4 | 32-28 | 4 | 39,758 | Steve Busby | Bob Stanley | Bob Stanley | Steve Busby | | 312 | 307 | 5 |
| 1979-06-12 | vs BOS | 61 | W 7-6 | 33-28 | 3 | 26,943 | Rich Gale | Chuck Rainey | Al Hrabosky | Dick Drago | | 319 | 313 | 6 |
| 1979-06-13 | vs BOS | 62 | L 3-11 | 33-29 | 4 | 27,940 | Larry Gura | Steve Renko | Steve Renko | Larry Gura | | 322 | 324 | -2 |
| 1979-06-15 | @ MIL | 63 | W 14-11 | 34-29 | 2 | 32,812 | Paul Splittorff | Mike Caldwell | Steve Mingori | Reggie Cleveland | Marty Pattin | 336 | 335 | 1 |
| 1979-06-16 | @ MIL | 64 | L 2-3 | 34-30 | 3 | 43,784 | Steve Busby | Jim Slaton | Jim Slaton | Steve Busby | | 338 | 338 | 0 |
| 1979-06-17 | @ MIL | 65 | L 3-5 | 34-31 | 4 | 28,100 | Rich Gale | Lary Sorensen | Lary Sorensen | Rich Gale | | 341 | 343 | -2 |
| 1979-06-18 | @ OAK | 66 | W 3-2 | 35-31 | 2 | 6,864 | Larry Gura | Mike Norris | Larry Gura | Mike Norris | Al Hrabosky | 344 | 345 | -1 |
| 1979-06-19 | @ OAK | 67 | L 5-6 | 35-32 | 3 | 1,485 | Dennis Leonard | Matt Keough | Dave Heaverlo | Al Hrabosky | | 349 | 351 | -2 |
| 1979-06-20 | @ OAK | 68 | W 9-2 | 36-32 | 2 | 1,503 | Paul Splittorff | Dave Hamilton | Paul Splittorff | Dave Hamilton | | 358 | 353 | 5 |
| 1979-06-21 | @ OAK | 69 | L 7-10 | 36-33 | 3 | 2,132 | Steve Busby | Steve McCatty | Steve McCatty | Steve Busby | Dave Heaverlo | 365 | 363 | 2 |
| 1979-06-22 | @ CAL | 70 | W 9-5 | 37-33 | 2 | 30,737 | Rich Gale | Nolan Ryan | Rich Gale | Nolan Ryan | | 374 | 368 | 6 |
| 1979-06-23 | @ CAL | 71 | W 13-4 | 38-33 | 2 | 41,002 | Larry Gura | Jim Barr | Larry Gura | Jim Barr | Eduardo Rodriguez | 387 | 372 | 15 |
| 1979-06-24 | @ CAL | 72 | W 5-2 | 39-33 | 2 | 32,210 | Dennis Leonard | Dave Frost | Dennis Leonard | Dave Frost | | 392 | 374 | 18 |
| 1979-06-26 | vs OAK | 73 | W 7-6 | 40-33 | 2 | 24,550 | Paul Splittorff | Steve McCatty | Al Hrabosky | Jim Todd | | 399 | 380 | 19 |
| 1979-06-27 | vs OAK | 74 | W 10-3 | 41-33 | 1 | 31,101 | Steve Busby | Mike Morgan | Steve Busby | Mike Morgan | | 409 | 383 | 26 |
| 1979-06-28 | vs OAK | 75 | W 7-6 | 42-33 | 1 | 22,307 | Larry Gura | Brian Kingman | Al Hrabosky | Dave Heaverlo | | 416 | 389 | 27 |
| 1979-06-29 | vs CAL | 76 | L 5-6 | 42-34 | 2 | 36,705 | Dennis Leonard | Dave Frost | Mark Clear | Marty Pattin | Dave LaRoche | 421 | 395 | 26 |
| 1979-06-30 | vs CAL | 77 | L 5-8 | 42-35 | 3 | 41,451 | Rich Gale | Don Aase | Don Aase | Rich Gale | Dave LaRoche | 426 | 403 | 23 |
| 1979-07-01 | vs CAL | 78 | L 2-14 | 42-36 | 4 | 32,636 | Paul Splittorff | Nolan Ryan | Nolan Ryan | Paul Splittorff | | 428 | 417 | 11 |
| 1979-07-03 | @ BOS | 79 | L 0-10 | 42-37 | 4 | 34,814 | Steve Busby | Steve Renko | Steve Renko | Steve Busby | | 428 | 427 | 1 |
| 1979-07-04 | @ BOS | 80 | L 4-6 | 42-38 | 4 | 27,870 | Dennis Leonard | Mike Torrez | Mike Torrez | Al Hrabosky | | 432 | 433 | -1 |
| 1979-07-05 | @ BOS | 81 | L 4-5 | 42-39 | 4 | 34,795 | Rich Gale | Chuck Rainey | Bob Stanley | Bill Paschall | | 436 | 438 | -2 |
| 1979-07-06 | vs CHA | 82 | L 1-4 | 42-40 | 4 | 22,509 | Paul Splittorff | Steve Trout | Steve Trout | Paul Splittorff | | 437 | 442 | -5 |
| 1979-07-07 | vs CHA | 83 | W 4-3 | 43-40 | 4 | 31,760 | Larry Gura | Ken Kravec | Steve Busby | Guy Hoffman | | 441 | 445 | -4 |
| 1979-07-08 | vs CHA | 84 | L 2-4 | 43-41 | 4 | 24,501 | Marty Pattin | Francisco Barrios | Francisco Barrios | Marty Pattin | Randy Scarbery | 443 | 449 | -6 |
| 1979-07-09 | @ CLE | 85 | L 2-8 | 43-42 | 4 | 9,148 | Dennis Leonard | David Clyde | David Clyde | Dennis Leonard | | 445 | 457 | -12 |
| 1979-07-10 | @ CLE | 86 | L 4-7 | 43-43 | 4 | 10,533 | Rich Gale | Eric Wilkins | Dan Spillner | Rich Gale | Victor Cruz | 449 | 464 | -15 |
| 1979-07-11 | @ CLE | 87 | L 8-9 | 43-44 | 4 | 11,587 | Paul Splittorff | Mike Paxton | Mike Paxton | Paul Splittorff | Victor Cruz | 457 | 473 | -16 |
| 1979-07-12 | vs TEX | 88 | L 2-6 | 43-45 | 4 | 27,834 | Larry Gura | Doc Medich | Doc Medich | Larry Gura | | 459 | 479 | -20 |
| 1979-07-13 | vs TEX | 89 | L 4-9 | 43-46 | 4 | 30,139 | Dennis Leonard | Steve Comer | Steve Comer | Dennis Leonard | Sparky Lyle | 463 | 488 | -25 |
| 1979-07-14 | vs TEX | 90 | L 3-7 | 43-47 | 4 | 39,282 | Rich Gale | Fergie Jenkins | Fergie Jenkins | Rich Gale | Jim Kern | 466 | 495 | -29 |
| 1979-07-15 | vs TEX | 91 | W 4-3 | 44-47 | 4 | 28,904 | Paul Splittorff | John Henry Johnson | Paul Splittorff | John Henry Johnson | | 470 | 498 | -28 |
| 1979-07-19 | vs CLE | 92 | L 1-2 | 44-48 | 4 | 24,046 | Dennis Leonard | Rick Wise | Rick Wise | Dennis Leonard | Sid Monge | 471 | 500 | -29 |
| 1979-07-20 | vs CLE | 93 | W 9-1 | 45-48 | 4 | 38,461 | Rich Gale | Rick Waits | Rich Gale | Rick Waits | | 480 | 501 | -21 |
| 1979-07-21 | @ TEX | 94 | L 1-4 | 45-49 | 4 | 36,258 | Paul Splittorff | Doc Medich | Doc Medich | Paul Splittorff | Jim Kern | 481 | 505 | -24 |
| 1979-07-22 | @ TEX | 95 | W 7-6 | 46-49 | 4 | 29,863 | Larry Gura | Steve Comer | Dan Quisenberry | Sparky Lyle | | 488 | 511 | -23 |
| 1979-07-23 | @ TEX | 96 | W 5-4 | 47-49 | 4 | 24,141 | Dennis Leonard | Fergie Jenkins | Dennis Leonard | Fergie Jenkins | Dan Quisenberry | 493 | 515 | -22 |
| 1979-07-24 | @ CHA | 97 | W 11-6 | 48-49 | 4 | 11,393 | Rich Gale | Ken Kravec | Steve Mingori | Guy Hoffman | | 504 | 521 | -17 |
| 1979-07-25 | @ CHA | 98 | L 2-6 | 48-50 | 4 | 11,176 | Paul Splittorff | Rich Wortham | Rich Wortham | Paul Splittorff | | 506 | 527 | -21 |
| 1979-07-26 | @ CHA | 99 | W 6-1 | 49-50 | 4 | 22,893 | Larry Gura | Ross Baumgarten | Larry Gura | Ross Baumgarten | | 512 | 528 | -16 |
| 1979-07-27 | vs BAL | 100 | L 0-8 | 49-51 | 4 | 33,629 | Dennis Leonard | Mike Flanagan | Mike Flanagan | Dennis Leonard | | 512 | 536 | -24 |
| 1979-07-28 | vs BAL | 101 | W 6-3 | 50-51 | 4 | 40,448 | Rich Gale | Dennis Martinez | Rich Gale | Dennis Martinez | | 518 | 539 | -21 |
| 1979-07-29 | vs BAL | 102 | L 4-6 | 50-52 | 4 | 30,193 | Paul Splittorff | Scott McGregor | Scott McGregor | Paul Splittorff | Dave Ford | 522 | 545 | -23 |
| 1979-07-30 | vs TOR | 103 | W 9-0 | 51-52 | 4 | 31,572 | Larry Gura | Dave Stieb | Larry Gura | Dave Stieb | | 531 | 545 | -14 |
| 1979-07-31 | vs TOR | 104 | W 6-5 | 52-52 | 4 | 22,156 | Dennis Leonard | Tom Underwood | Marty Pattin | Jesse Jefferson | Al Hrabosky | 537 | 550 | -13 |
| 1979-08-01 | vs TOR | 105 | W 4-3 | 53-52 | 4 | 24,077 | Rich Gale | Phil Huffman | Rich Gale | Phil Huffman | Al Hrabosky | 541 | 553 | -12 |
| 1979-08-03 | @ DET | 106 | W 5-3 | 54-53 | 4 | 0 | Steve Busby | Pat Underwood | Steve Busby | Pat Underwood | Al Hrabosky | 546 | 556 | -10 |
| 1979-08-03 | @ DET | 107 | L 3-4 | 54-53 | 4 | 43,047 | Paul Splittorff | Bruce Robbins | Aurelio Lopez | Steve Mingori | | 549 | 560 | -11 |
| 1979-08-04 | @ DET | 108 | L 2-5 | 54-54 | 4 | 39,402 | Larry Gura | Mike Chris | Mike Chris | Larry Gura | John Hiller | 551 | 565 | -14 |
| 1979-08-05 | @ DET | 109 | W 3-2 | 55-54 | 4 | 28,703 | Dennis Leonard | Dan Petry | Dennis Leonard | Dan Petry | Dan Quisenberry | 554 | 567 | -13 |
| 1979-08-06 | @ TOR | 110 | W 16-12 | 56-54 | 4 | 15,108 | Rich Gale | Dave Stieb | Steve Mingori | Dave Stieb | | 570 | 579 | -9 |
| 1979-08-07 | @ TOR | 111 | L 2-3 | 56-55 | 4 | 23,779 | Paul Splittorff | Tom Underwood | Tom Underwood | Paul Splittorff | | 572 | 582 | -10 |
| 1979-08-09 | @ TOR | 112 | W 10-3 | 57-55 | 4 | 20,102 | Larry Gura | Phil Huffman | Larry Gura | Phil Huffman | | 582 | 585 | -3 |
| 1979-08-10 | vs DET | 113 | W 7-6 | 59-55 | 3 | 0 | Rich Gale | Dan Petry | Dan Quisenberry | Aurelio Lopez | | 589 | 591 | -2 |
| 1979-08-10 | vs DET | 114 | W 7-3 | 59-55 | 3 | 37,012 | Dennis Leonard | Pat Underwood | Dennis Leonard | Pat Underwood | Dan Quisenberry | 596 | 594 | 2 |
| 1979-08-11 | vs DET | 115 | W 11-5 | 60-55 | 3 | 40,255 | Paul Splittorff | Jack Billingham | Paul Splittorff | Jack Billingham | | 607 | 599 | 8 |
| 1979-08-12 | vs DET | 116 | W 7-1 | 61-55 | 3 | 32,671 | Craig Chamberlain | Milt Wilcox | Craig Chamberlain | Milt Wilcox | | 614 | 600 | 14 |
| 1979-08-13 | @ MIL | 117 | L 4-5 | 61-56 | 3 | 12,578 | Larry Gura | Jim Slaton | Jim Slaton | Dan Quisenberry | | 618 | 605 | 13 |
| 1979-08-14 | @ MIL | 118 | L 2-5 | 61-57 | 3 | 21,657 | Dennis Leonard | Mike Caldwell | Mike Caldwell | Dennis Leonard | Bill Castro | 620 | 610 | 10 |
| 1979-08-15 | @ MIL | 119 | L 5-6 | 61-58 | 3 | 17,175 | Rich Gale | Bill Travers | Jerry Augustine | Dan Quisenberry | | 625 | 616 | 9 |
| 1979-08-16 | @ BAL | 120 | W 4-2 | 62-58 | 3 | 18,932 | Paul Splittorff | Dennis Martinez | Paul Splittorff | Dennis Martinez | | 629 | 618 | 11 |
| 1979-08-17 | @ BAL | 121 | W 7-1 | 63-58 | 3 | 29,348 | Craig Chamberlain | Jim Palmer | Craig Chamberlain | Jim Palmer | | 636 | 619 | 17 |
| 1979-08-18 | @ BAL | 122 | L 2-9 | 63-59 | 3 | 37,645 | Larry Gura | Scott McGregor | Scott McGregor | Larry Gura | Dave Ford | 638 | 628 | 10 |
| 1979-08-19 | @ BAL | 123 | W 11-7 | 64-59 | 3 | 32,058 | Dennis Leonard | Steve Stone | Steve Busby | Don Stanhouse | | 649 | 635 | 14 |
| 1979-08-20 | vs NYA | 124 | L 4-17 | 64-60 | 3 | 41,305 | Rich Gale | Luis Tiant | Luis Tiant | Rich Gale | Don Hood | 653 | 652 | 1 |
| 1979-08-21 | vs NYA | 125 | L 2-6 | 64-61 | 3 | 38,514 | Paul Splittorff | Tommy John | Rich Gossage | Paul Splittorff | | 655 | 658 | -3 |
| 1979-08-22 | vs NYA | 126 | W 3-1 | 65-61 | 3 | 34,400 | Larry Gura | Jim Beattie | Larry Gura | Jim Beattie | | 658 | 659 | -1 |
| 1979-08-24 | vs BOS | 127 | W 4-2 | 66-61 | 3 | 39,782 | Craig Chamberlain | Dennis Eckersley | Craig Chamberlain | Dennis Eckersley | | 662 | 661 | 1 |
| 1979-08-25 | vs BOS | 128 | W 1-0 | 67-61 | 3 | 37,851 | Dennis Leonard | Mike Torrez | Dennis Leonard | Mike Torrez | | 663 | 661 | 2 |
| 1979-08-26 | vs BOS | 129 | W 6-3 | 68-61 | 3 | 34,915 | Paul Splittorff | Steve Renko | Paul Splittorff | Steve Renko | | 669 | 664 | 5 |
| 1979-08-27 | vs MIL | 130 | W 10-9 | 69-61 | 2 | 30,758 | Rich Gale | Lary Sorensen | Al Hrabosky | Bob Galasso | | 679 | 673 | 6 |
| 1979-08-28 | vs MIL | 131 | L 6-11 | 69-62 | 3 | 26,278 | Craig Chamberlain | Moose Haas | Moose Haas | Craig Chamberlain | | 685 | 684 | 1 |
| 1979-08-29 | vs MIL | 132 | W 18-8 | 70-62 | 2 | 22,761 | Dennis Leonard | Jim Slaton | Dennis Leonard | Jim Slaton | | 703 | 692 | 11 |
| 1979-08-30 | @ NYA | 133 | W 8-3 | 71-62 | 1 | 30,717 | Larry Gura | Luis Tiant | Larry Gura | Luis Tiant | | 711 | 695 | 16 |
| 1979-08-31 | @ NYA | 134 | L 3-7 | 71-63 | 2 | 35,229 | Paul Splittorff | Tommy John | Tommy John | Paul Splittorff | | 714 | 702 | 12 |
| 1979-09-01 | @ NYA | 135 | W 9-8 | 72-63 | 2 | 30,130 | Rich Gale | Ken Clay | Al Hrabosky | Jim Kaat | Renie Martin | 723 | 710 | 13 |
| 1979-09-02 | @ NYA | 136 | L 5-6 | 72-64 | 2 | 34,008 | Craig Chamberlain | Catfish Hunter | Rich Gossage | Steve Mingori | | 728 | 716 | 12 |
| 1979-09-03 | @ MIN | 137 | W 1-0 | 73-64 | 2 | 19,643 | Dennis Leonard | Geoff Zahn | Dennis Leonard | Geoff Zahn | | 729 | 716 | 13 |
| 1979-09-04 | @ MIN | 138 | L 1-5 | 73-65 | 2 | 10,610 | Larry Gura | Jerry Koosman | Jerry Koosman | Larry Gura | | 730 | 721 | 9 |
| 1979-09-05 | @ MIN | 139 | L 3-8 | 73-66 | 2 | 11,647 | Paul Splittorff | Dave Goltz | Dave Goltz | Paul Splittorff | | 733 | 729 | 4 |
| 1979-09-07 | @ SEA | 140 | W 6-2 | 74-66 | 2 | 6,843 | Craig Chamberlain | Rick Honeycutt | Craig Chamberlain | Rick Honeycutt | | 739 | 731 | 8 |
| 1979-09-08 | @ SEA | 141 | L 2-4 | 74-67 | 2 | 12,340 | Dennis Leonard | Floyd Bannister | Floyd Bannister | Dennis Leonard | | 741 | 735 | 6 |
| 1979-09-09 | @ SEA | 142 | W 3-1 | 75-67 | 2 | 7,236 | Larry Gura | Mike Parrott | Larry Gura | Mike Parrott | | 744 | 736 | 8 |
| 1979-09-10 | vs MIN | 143 | W 6-5 | 76-68 | 2 | 0 | Marty Pattin | Roger Erickson | Dan Quisenberry | Mike Marshall | | 750 | 741 | 9 |
| 1979-09-10 | vs MIN | 144 | L 2-5 | 76-68 | 2 | 31,337 | Paul Splittorff | Dave Goltz | Dave Goltz | Paul Splittorff | | 752 | 746 | 6 |
| 1979-09-11 | vs MIN | 145 | L 1-3 | 76-69 | 2 | 21,253 | Craig Chamberlain | Geoff Zahn | Geoff Zahn | Craig Chamberlain | Mike Marshall | 753 | 749 | 4 |
| 1979-09-12 | vs MIN | 146 | W 4-0 | 77-69 | 2 | 20,524 | Dennis Leonard | Jerry Koosman | Dennis Leonard | Jerry Koosman | | 757 | 749 | 8 |
| 1979-09-14 | vs SEA | 147 | L 5-7 | 77-70 | 2 | 24,240 | Larry Gura | Floyd Bannister | Floyd Bannister | Larry Gura | Byron McLaughlin | 762 | 756 | 6 |
| 1979-09-15 | vs SEA | 148 | W 5-4 | 78-70 | 2 | 30,514 | Craig Chamberlain | Mike Parrott | Al Hrabosky | Byron McLaughlin | | 767 | 760 | 7 |
| 1979-09-16 | vs SEA | 149 | L 3-6 | 78-71 | 2 | 27,828 | Paul Splittorff | Rob Dressler | Rob Dressler | Paul Splittorff | | 770 | 766 | 4 |
| 1979-09-17 | vs CAL | 150 | W 16-4 | 79-71 | 2 | 38,327 | Dennis Leonard | Chris Knapp | Dennis Leonard | Chris Knapp | | 786 | 770 | 16 |
| 1979-09-18 | vs CAL | 151 | L 4-6 | 79-72 | 2 | 29,733 | Rich Gale | Dave Frost | Dave Frost | Rich Gale | John Montague | 790 | 776 | 14 |
| 1979-09-19 | vs CAL | 152 | W 6-4 | 80-72 | 2 | 31,412 | Larry Gura | Nolan Ryan | Larry Gura | Nolan Ryan | Dan Quisenberry | 796 | 780 | 16 |
| 1979-09-20 | vs CAL | 153 | L 6-11 | 80-73 | 2 | 32,659 | Craig Chamberlain | Jim Barr | Jim Barr | Craig Chamberlain | Don Aase | 802 | 791 | 11 |
| 1979-09-21 | @ OAK | 154 | W 13-4 | 81-73 | 2 | 2,340 | Paul Splittorff | Rick Langford | Paul Splittorff | Rick Langford | | 815 | 795 | 20 |
| 1979-09-22 | @ OAK | 155 | L 0-2 | 81-74 | 2 | 2,111 | Dennis Leonard | Matt Keough | Matt Keough | Dennis Leonard | | 815 | 797 | 18 |
| 1979-09-23 | @ OAK | 156 | W 4-2 | 82-74 | 2 | 2,583 | Marty Pattin | Steve McCatty | Marty Pattin | Steve McCatty | Dan Quisenberry | 819 | 799 | 20 |
| 1979-09-24 | @ CAL | 157 | L 3-4 | 82-75 | 2 | 40,423 | Larry Gura | Nolan Ryan | Nolan Ryan | Larry Gura | | 822 | 803 | 19 |
| 1979-09-25 | @ CAL | 158 | L 1-4 | 82-76 | 2 | 40,631 | Craig Chamberlain | Frank Tanana | Frank Tanana | Craig Chamberlain | | 823 | 807 | 16 |
| 1979-09-26 | @ CAL | 159 | W 4-0 | 83-76 | 2 | 40,565 | Dennis Leonard | Dave LaRoche | Dennis Leonard | Dave LaRoche | | 827 | 807 | 20 |
| 1979-09-28 | vs OAK | 160 | W 13-1 | 84-76 | 2 | 20,908 | Larry Gura | Steve McCatty | Larry Gura | Steve McCatty | | 840 | 808 | 32 |
| 1979-09-29 | vs OAK | 161 | W 6-2 | 85-76 | 2 | 24,856 | Paul Splittorff | Mike Morgan | Paul Splittorff | Mike Morgan | Renie Martin | 846 | 810 | 36 |
| 1979-09-30 | vs OAK | 162 | L 5-6 | 85-77 | 2 | 23,842 | Dennis Leonard | Craig Minetto | Brian Kingman | Dennis Leonard | | 851 | 816 | 35 |