| 1979-04-07 | vs TEX | 1 | L 2-8 | 0-1 | 5 | 43,708 | Dave Rozema | Fergie Jenkins | Fergie Jenkins | Dave Rozema | | 2 | 8 | -6 |
| 1979-04-09 | @ KCA | 2 | W 7-3 | 1-1 | 4 | 18,429 | Milt Wilcox | Rich Gale | Milt Wilcox | Rich Gale | John Hiller | 9 | 11 | -2 |
| 1979-04-11 | @ KCA | 3 | L 3-10 | 1-2 | 5 | 14,833 | Jack Billingham | Larry Gura | Eduardo Rodriguez | Bruce Taylor | | 12 | 21 | -9 |
| 1979-04-13 | @ TEX | 4 | L 4-5 | 1-3 | 6 | 23,095 | Dave Rozema | Dock Ellis | Jim Kern | Sheldon Burnside | Sparky Lyle | 16 | 26 | -10 |
| 1979-04-14 | @ TEX | 5 | L 5-7 | 1-4 | 6 | 30,014 | Milt Wilcox | Doyle Alexander | Sparky Lyle | Steve Baker | | 21 | 33 | -12 |
| 1979-04-15 | @ TEX | 6 | W 11-6 | 2-4 | 6 | 19,353 | Kip Young | Steve Comer | Sheldon Burnside | Sparky Lyle | | 32 | 39 | -7 |
| 1979-04-16 | vs KCA | 7 | W 10-4 | 3-4 | 5 | 9,457 | Jack Billingham | Larry Gura | Jack Billingham | Larry Gura | Steve Baker | 42 | 43 | -1 |
| 1979-04-17 | vs KCA | 8 | W 6-3 | 4-4 | 4 | 15,275 | Dave Rozema | Paul Splittorff | John Hiller | Paul Splittorff | | 48 | 46 | 2 |
| 1979-04-20 | vs TOR | 9 | W 7-2 | 5-4 | 4 | 13,617 | Milt Wilcox | Mark Lemongello | Milt Wilcox | Mark Lemongello | | 55 | 48 | 7 |
| 1979-04-21 | vs TOR | 10 | L 4-5 | 5-5 | 4 | 10,904 | Jack Billingham | Phil Huffman | Phil Huffman | Jack Billingham | Dave Freisleben | 59 | 53 | 6 |
| 1979-04-22 | vs TOR | 11 | W 4-1 | 6-5 | 3 | 14,543 | Dave Rozema | Tom Underwood | Dave Rozema | Tom Underwood | | 63 | 54 | 9 |
| 1979-04-26 | @ MIL | 12 | L 1-5 | 6-7 | 5 | 0 | Jack Billingham | Jim Slaton | Jim Slaton | Jack Billingham | | 64 | 59 | 5 |
| 1979-04-26 | @ MIL | 13 | L 5-7 | 6-7 | 5 | 8,839 | Steve Baker | Jerry Augustine | Reggie Cleveland | Steve Baker | Bill Castro | 69 | 66 | 3 |
| 1979-04-27 | vs MIN | 14 | L 3-5 | 6-8 | 5 | 11,262 | Dave Rozema | Jerry Koosman | Jerry Koosman | Dave Rozema | Mike Marshall | 72 | 71 | 1 |
| 1979-04-28 | vs MIN | 15 | W 5-3 | 7-8 | 5 | 8,818 | Kip Young | Dave Goltz | Kip Young | Dave Goltz | John Hiller | 77 | 74 | 3 |
| 1979-04-29 | vs MIN | 16 | L 3-5 | 7-9 | 5 | 12,577 | Milt Wilcox | Geoff Zahn | Geoff Zahn | Milt Wilcox | Mike Marshall | 80 | 79 | 1 |
| 1979-05-01 | @ CHA | 17 | W 5-2 | 8-9 | 5 | 16,470 | Steve Baker | Ken Kravec | Steve Baker | Ken Kravec | Jack Billingham | 85 | 81 | 4 |
| 1979-05-03 | @ MIN | 18 | L 6-7 | 8-10 | 5 | 4,581 | Kip Young | Roger Erickson | Mike Marshall | Jack Billingham | | 91 | 88 | 3 |
| 1979-05-04 | @ MIN | 19 | L 6-7 | 8-11 | 5 | 5,768 | Milt Wilcox | Pete Redfern | Mike Marshall | Aurelio Lopez | | 97 | 95 | 2 |
| 1979-05-05 | @ MIN | 20 | W 8-4 | 9-11 | 5 | 15,002 | Mark Fidrych | Paul Hartzell | Jack Billingham | Paul Hartzell | | 105 | 99 | 6 |
| 1979-05-06 | @ MIN | 21 | L 6-9 | 9-12 | 5 | 15,235 | Steve Baker | Jerry Koosman | Mike Marshall | John Hiller | | 111 | 108 | 3 |
| 1979-05-07 | vs CHA | 22 | W 5-4 | 10-12 | 5 | 13,921 | Dave Rozema | Steve Trout | Bruce Taylor | Steve Trout | | 116 | 112 | 4 |
| 1979-05-08 | vs CHA | 23 | W 10-8 | 11-12 | 5 | 13,769 | Kip Young | Francisco Barrios | Jack Billingham | Randy Scarbery | | 126 | 120 | 6 |
| 1979-05-09 | vs CHA | 24 | L 4-5 | 11-13 | 5 | 13,167 | Milt Wilcox | Ross Baumgarten | Ross Baumgarten | Milt Wilcox | Ken Kravec | 130 | 125 | 5 |
| 1979-05-11 | vs MIL | 25 | L 1-5 | 11-14 | 5 | 42,563 | Mark Fidrych | Lary Sorensen | Lary Sorensen | Mark Fidrych | | 131 | 130 | 1 |
| 1979-05-12 | vs MIL | 26 | L 2-3 | 11-15 | 5 | 19,801 | Dave Rozema | Bill Travers | Jerry Augustine | Bruce Taylor | Bob McClure | 133 | 133 | 0 |
| 1979-05-13 | vs MIL | 27 | W 6-2 | 12-15 | 5 | 12,162 | Jack Morris | Moose Haas | Jack Morris | Moose Haas | Jack Billingham | 139 | 135 | 4 |
| 1979-05-14 | @ NYA | 28 | W 3-1 | 13-15 | 5 | 15,650 | Milt Wilcox | Ed Figueroa | Milt Wilcox | Ed Figueroa | | 142 | 136 | 6 |
| 1979-05-15 | @ NYA | 29 | L 3-11 | 13-16 | 5 | 18,876 | Steve Baker | Tommy John | Tommy John | Steve Baker | | 145 | 147 | -2 |
| 1979-05-16 | @ NYA | 30 | L 2-6 | 13-17 | 5 | 43,843 | Mark Fidrych | Ron Guidry | Ron Guidry | Mark Fidrych | | 147 | 153 | -6 |
| 1979-05-18 | @ CLE | 31 | W 5-3 | 14-17 | 5 | 10,452 | Dave Rozema | Wayne Garland | John Hiller | Sid Monge | | 152 | 156 | -4 |
| 1979-05-19 | @ CLE | 32 | L 0-6 | 14-18 | 5 | 7,229 | Jack Morris | Rick Waits | Rick Waits | Jack Morris | | 152 | 162 | -10 |
| 1979-05-20 | @ CLE | 33 | L 7-9 | 14-19 | 5 | 11,571 | Milt Wilcox | Eric Wilkins | Dan Spillner | John Hiller | | 159 | 171 | -12 |
| 1979-05-21 | vs NYA | 34 | W 3-1 | 15-19 | 5 | 26,153 | Jack Billingham | Ron Guidry | Jack Billingham | Ron Guidry | | 162 | 172 | -10 |
| 1979-05-22 | vs NYA | 35 | L 8-12 | 15-20 | 5 | 33,497 | Mark Fidrych | Luis Tiant | Luis Tiant | Mark Fidrych | | 170 | 184 | -14 |
| 1979-05-23 | vs NYA | 36 | W 4-3 | 16-20 | 5 | 21,671 | Jack Morris | Jim Beattie | John Hiller | Ken Clay | | 174 | 187 | -13 |
| 1979-05-26 | vs BAL | 37 | L 5-7 | 16-21 | 6 | 14,583 | Milt Wilcox | Mike Flanagan | Sammy Stewart | John Hiller | | 179 | 194 | -15 |
| 1979-05-27 | vs BAL | 38 | W 5-1 | 18-21 | 5 | 0 | Jack Billingham | Scott McGregor | Jack Billingham | Scott McGregor | | 184 | 195 | -11 |
| 1979-05-27 | vs BAL | 39 | W 10-3 | 18-21 | 5 | 27,425 | Dave Rozema | Steve Stone | Dave Rozema | Steve Stone | | 194 | 198 | -4 |
| 1979-05-28 | @ TOR | 40 | W 6-2 | 19-21 | 5 | 10,740 | Jack Morris | Dave Lemanczyk | Jack Morris | Dave Lemanczyk | | 200 | 200 | 0 |
| 1979-05-29 | @ TOR | 41 | W 9-8 | 20-21 | 5 | 11,449 | Steve Baker | Jerry Garvin | Dave Tobik | Tom Buskey | John Hiller | 209 | 208 | 1 |
| 1979-05-30 | @ TOR | 42 | W 8-2 | 21-21 | 5 | 21,359 | Milt Wilcox | Phil Huffman | Milt Wilcox | Phil Huffman | | 217 | 210 | 7 |
| 1979-05-31 | @ TOR | 43 | W 1-0 | 22-21 | 5 | 12,423 | Pat Underwood | Tom Underwood | Pat Underwood | Tom Underwood | John Hiller | 218 | 210 | 8 |
| 1979-06-01 | @ OAK | 44 | L 2-3 | 22-22 | 5 | 2,731 | Jack Billingham | Steve McCatty | Steve McCatty | John Hiller | | 220 | 213 | 7 |
| 1979-06-02 | @ OAK | 45 | W 9-3 | 23-22 | 5 | 3,420 | Jack Morris | Craig Minetto | Jack Morris | Craig Minetto | Dave Tobik | 229 | 216 | 13 |
| 1979-06-03 | @ OAK | 46 | W 2-0 | 24-22 | 5 | 4,030 | Dave Rozema | John Henry Johnson | Dave Rozema | John Henry Johnson | | 231 | 216 | 15 |
| 1979-06-04 | @ SEA | 47 | L 2-11 | 24-23 | 5 | 5,529 | Milt Wilcox | Rick Honeycutt | Rick Honeycutt | Milt Wilcox | | 233 | 227 | 6 |
| 1979-06-05 | @ SEA | 48 | W 3-1 | 25-23 | 5 | 6,156 | Jack Billingham | Glenn Abbott | Jack Billingham | Glenn Abbott | John Hiller | 236 | 228 | 8 |
| 1979-06-06 | @ SEA | 49 | L 3-4 | 25-24 | 5 | 6,382 | Jack Morris | Floyd Bannister | Floyd Bannister | Jack Morris | Byron McLaughlin | 239 | 232 | 7 |
| 1979-06-08 | @ CAL | 50 | L 4-6 | 25-25 | 5 | 28,298 | Milt Wilcox | Don Aase | Don Aase | Milt Wilcox | Mark Clear | 243 | 238 | 5 |
| 1979-06-09 | @ CAL | 51 | L 1-9 | 25-26 | 6 | 36,499 | Dave Rozema | Nolan Ryan | Nolan Ryan | Dave Rozema | | 244 | 247 | -3 |
| 1979-06-10 | @ CAL | 52 | W 10-7 | 26-26 | 5 | 30,229 | Jack Billingham | Frank Tanana | Fernando Arroyo | Frank Tanana | John Hiller | 254 | 254 | 0 |
| 1979-06-11 | vs OAK | 53 | W 3-1 | 27-26 | 5 | 15,625 | Jack Morris | Steve McCatty | Jack Morris | Steve McCatty | | 257 | 255 | 2 |
| 1979-06-12 | vs OAK | 54 | W 9-2 | 28-26 | 5 | 16,278 | Pat Underwood | Craig Minetto | Pat Underwood | Craig Minetto | | 266 | 257 | 9 |
| 1979-06-13 | vs SEA | 55 | W 7-3 | 29-26 | 5 | 16,113 | Milt Wilcox | Mike Parrott | Milt Wilcox | Mike Parrott | John Hiller | 273 | 260 | 13 |
| 1979-06-14 | vs SEA | 56 | L 2-3 | 29-27 | 5 | 21,957 | Jack Billingham | Rick Honeycutt | Shane Rawley | John Hiller | Byron McLaughlin | 275 | 263 | 12 |
| 1979-06-15 | vs CAL | 57 | L 7-8 | 29-28 | 5 | 41,151 | Dave Rozema | Jim Barr | Mark Clear | Dave Tobik | | 282 | 271 | 11 |
| 1979-06-16 | vs CAL | 58 | L 2-4 | 29-29 | 6 | 39,240 | Jack Morris | Dave Frost | Dave Frost | Jack Morris | Dave LaRoche | 284 | 275 | 9 |
| 1979-06-17 | vs CAL | 59 | W 8-4 | 30-29 | 5 | 32,744 | Pat Underwood | Don Aase | Aurelio Lopez | Don Aase | | 292 | 279 | 13 |
| 1979-06-18 | @ BOS | 60 | L 8-9 | 30-30 | 6 | 29,533 | Milt Wilcox | Steve Renko | Dick Drago | Fernando Arroyo | Bill Campbell | 300 | 288 | 12 |
| 1979-06-19 | @ BOS | 61 | W 10-4 | 31-30 | 5 | 34,153 | Jack Billingham | Joel Finch | Aurelio Lopez | Bob Stanley | | 310 | 292 | 18 |
| 1979-06-20 | @ BOS | 62 | L 3-13 | 31-31 | 5 | 34,035 | Steve Baker | Mike Torrez | Mike Torrez | Steve Baker | | 313 | 305 | 8 |
| 1979-06-21 | @ BOS | 63 | L 2-3 | 31-32 | 5 | 34,316 | Jack Morris | Dennis Eckersley | Dennis Eckersley | Jack Morris | | 315 | 308 | 7 |
| 1979-06-22 | @ BAL | 64 | L 5-6 | 31-33 | 5 | 35,456 | Pat Underwood | Mike Flanagan | Tippy Martinez | Dave Tobik | | 320 | 314 | 6 |
| 1979-06-23 | @ BAL | 65 | L 6-8 | 31-35 | 6 | 0 | Milt Wilcox | Scott McGregor | Tippy Martinez | John Hiller | | 326 | 322 | 4 |
| 1979-06-23 | @ BAL | 66 | L 5-6 | 31-35 | 6 | 45,814 | Jack Billingham | Jim Palmer | Sammy Stewart | Jack Billingham | | 331 | 328 | 3 |
| 1979-06-24 | @ BAL | 67 | W 6-4 | 32-35 | 5 | 41,200 | Steve Baker | Dennis Martinez | Aurelio Lopez | Dennis Martinez | | 337 | 332 | 5 |
| 1979-06-26 | vs BOS | 68 | W 6-4 | 33-35 | 5 | 36,247 | Jack Morris | Dennis Eckersley | Jack Morris | Bill Campbell | | 343 | 336 | 7 |
| 1979-06-27 | vs BOS | 69 | L 1-3 | 33-36 | 5 | 32,381 | Pat Underwood | Joel Finch | Bob Stanley | Dave Tobik | | 344 | 339 | 5 |
| 1979-06-28 | vs BOS | 70 | W 6-3 | 34-36 | 5 | 32,755 | Jack Billingham | Steve Renko | Jack Billingham | Steve Renko | Aurelio Lopez | 350 | 342 | 8 |
| 1979-06-29 | vs CLE | 71 | W 8-6 | 35-36 | 5 | 20,289 | Steve Baker | Rick Waits | Milt Wilcox | Victor Cruz | Dave Tobik | 358 | 348 | 10 |
| 1979-06-30 | vs CLE | 72 | L 2-4 | 35-37 | 5 | 27,104 | Kip Young | David Clyde | David Clyde | Kip Young | Sid Monge | 360 | 352 | 8 |
| 1979-07-01 | vs CLE | 73 | W 10-2 | 36-37 | 5 | 20,121 | Jack Morris | Len Barker | Jack Morris | Len Barker | | 370 | 354 | 16 |
| 1979-07-02 | vs CLE | 74 | L 4-8 | 36-38 | 5 | 20,990 | Pat Underwood | Mike Paxton | Victor Cruz | Aurelio Lopez | | 374 | 362 | 12 |
| 1979-07-03 | vs TOR | 75 | L 1-9 | 36-39 | 5 | 20,885 | Jack Billingham | Balor Moore | Balor Moore | Jack Billingham | | 375 | 371 | 4 |
| 1979-07-04 | vs TOR | 76 | L 6-7 | 36-40 | 5 | 13,772 | Steve Baker | Dave Stieb | Tom Buskey | Dave Tobik | | 381 | 378 | 3 |
| 1979-07-05 | vs TOR | 77 | W 3-2 | 37-40 | 5 | 13,199 | Kip Young | Phil Huffman | Kip Young | Phil Huffman | Aurelio Lopez | 384 | 380 | 4 |
| 1979-07-06 | @ MIL | 78 | W 7-4 | 39-40 | 5 | 0 | Jack Morris | Moose Haas | Jack Morris | Moose Haas | Aurelio Lopez | 391 | 384 | 7 |
| 1979-07-06 | @ MIL | 79 | W 5-4 | 39-40 | 5 | 54,630 | Milt Wilcox | Jim Slaton | Milt Wilcox | Jim Slaton | Dave Tobik | 396 | 388 | 8 |
| 1979-07-07 | @ MIL | 80 | W 6-3 | 40-40 | 5 | 33,265 | Pat Underwood | Paul Mitchell | Pat Underwood | Paul Mitchell | Aurelio Lopez | 402 | 391 | 11 |
| 1979-07-08 | @ MIL | 81 | L 4-5 | 40-42 | 5 | 0 | Jack Billingham | Mike Caldwell | Mike Caldwell | John Hiller | | 406 | 396 | 10 |
| 1979-07-08 | @ MIL | 82 | L 1-3 | 40-42 | 5 | 39,141 | Dan Petry | Bill Travers | Bill Travers | Dan Petry | | 407 | 399 | 8 |
| 1979-07-09 | vs MIN | 83 | L 3-5 | 40-43 | 5 | 15,742 | Steve Baker | Jerry Koosman | Jerry Koosman | Steve Baker | Mike Marshall | 410 | 404 | 6 |
| 1979-07-10 | vs MIN | 84 | W 6-5 | 41-43 | 5 | 17,747 | Kip Young | Geoff Zahn | Aurelio Lopez | Mike Marshall | | 416 | 409 | 7 |
| 1979-07-11 | vs MIN | 85 | L 0-3 | 41-44 | 6 | 16,180 | Jack Morris | Darrell Jackson | Darrell Jackson | Jack Morris | Pete Redfern | 416 | 412 | 4 |
| 1979-07-12 | @ CHA | 86 | W 4-1 | 42-44 | 5 | 47,795 | Pat Underwood | Fred Howard | Pat Underwood | Fred Howard | Aurelio Lopez | 420 | 413 | 7 |
| 1979-07-12 | @ CHA | 87 | L 0-0 | 42-44 | 5 | 0 | 0 | 0 | 0 | 0 | | 420 | 413 | 7 |
| 1979-07-13 | @ CHA | 88 | W 3-1 | 43-44 | 5 | 27,587 | Dan Petry | Ken Kravec | Dan Petry | Ken Kravec | | 423 | 414 | 9 |
| 1979-07-14 | @ CHA | 89 | L 4-12 | 43-45 | 5 | 23,887 | Steve Baker | Ross Baumgarten | Ross Baumgarten | Steve Baker | | 427 | 426 | 1 |
| 1979-07-15 | @ CHA | 90 | W 14-5 | 44-45 | 5 | 25,873 | Jack Morris | Rich Wortham | Jack Morris | Rich Wortham | | 441 | 431 | 10 |
| 1979-07-19 | @ MIN | 91 | W 8-3 | 45-45 | 5 | 17,391 | Pat Underwood | Jerry Koosman | Pat Underwood | Jerry Koosman | | 449 | 434 | 15 |
| 1979-07-20 | @ MIN | 92 | L 6-14 | 45-46 | 5 | 14,509 | Jack Morris | Darrell Jackson | Gary Serum | Kip Young | | 455 | 448 | 7 |
| 1979-07-21 | vs CHA | 93 | W 4-2 | 46-46 | 5 | 37,596 | Dan Petry | Ross Baumgarten | Dan Petry | Ross Baumgarten | Aurelio Lopez | 459 | 450 | 9 |
| 1979-07-22 | vs CHA | 94 | W 1-0 | 47-46 | 5 | 27,461 | Milt Wilcox | Randy Scarbery | Milt Wilcox | Randy Scarbery | Aurelio Lopez | 460 | 450 | 10 |
| 1979-07-23 | vs CHA | 95 | L 3-11 | 47-47 | 5 | 21,436 | Steve Baker | Steve Trout | Steve Trout | Steve Baker | Ed Farmer | 463 | 461 | 2 |
| 1979-07-24 | vs MIL | 96 | L 4-5 | 47-48 | 5 | 20,630 | Pat Underwood | Bill Travers | Bill Travers | Pat Underwood | Bob Galasso | 467 | 466 | 1 |
| 1979-07-25 | vs MIL | 97 | W 11-2 | 48-48 | 5 | 17,858 | Jack Morris | Jim Slaton | Jack Morris | Jim Slaton | | 478 | 468 | 10 |
| 1979-07-26 | vs MIL | 98 | W 5-2 | 49-48 | 5 | 24,079 | Dan Petry | Moose Haas | Dan Petry | Moose Haas | | 483 | 470 | 13 |
| 1979-07-27 | @ TOR | 99 | W 4-3 | 50-48 | 5 | 23,814 | Milt Wilcox | Phil Huffman | Aurelio Lopez | Tom Buskey | | 487 | 473 | 14 |
| 1979-07-28 | @ TOR | 100 | L 0-3 | 50-49 | 5 | 30,131 | Bruce Robbins | Dave Lemanczyk | Dave Lemanczyk | Bruce Robbins | | 487 | 476 | 11 |
| 1979-07-29 | @ TOR | 101 | W 5-4 | 51-49 | 5 | 33,824 | Pat Underwood | Jim Clancy | Pat Underwood | Jim Clancy | Aurelio Lopez | 492 | 480 | 12 |
| 1979-07-30 | @ TEX | 102 | W 6-4 | 52-49 | 5 | 14,297 | Jack Morris | John Henry Johnson | John Hiller | Danny Darwin | Aurelio Lopez | 498 | 484 | 14 |
| 1979-07-31 | @ TEX | 103 | L 3-11 | 52-50 | 5 | 12,218 | Dan Petry | Doc Medich | Doc Medich | Dan Petry | | 501 | 495 | 6 |
| 1979-08-01 | @ TEX | 104 | L 3-4 | 52-51 | 5 | 13,803 | Milt Wilcox | Steve Comer | Steve Comer | Milt Wilcox | Jim Kern | 504 | 499 | 5 |
| 1979-08-03 | vs KCA | 105 | L 3-5 | 53-52 | 5 | 0 | Pat Underwood | Steve Busby | Steve Busby | Pat Underwood | Al Hrabosky | 507 | 504 | 3 |
| 1979-08-03 | vs KCA | 106 | W 4-3 | 53-52 | 5 | 43,047 | Bruce Robbins | Paul Splittorff | Aurelio Lopez | Steve Mingori | | 511 | 507 | 4 |
| 1979-08-04 | vs KCA | 107 | W 5-2 | 54-52 | 5 | 39,402 | Mike Chris | Larry Gura | Mike Chris | Larry Gura | John Hiller | 516 | 509 | 7 |
| 1979-08-05 | vs KCA | 108 | L 2-3 | 54-53 | 5 | 28,703 | Dan Petry | Dennis Leonard | Dennis Leonard | Dan Petry | Dan Quisenberry | 518 | 512 | 6 |
| 1979-08-07 | vs TEX | 109 | W 3-1 | 56-53 | 5 | 0 | Milt Wilcox | Steve Comer | Milt Wilcox | Jim Kern | | 521 | 513 | 8 |
| 1979-08-07 | vs TEX | 110 | W 8-2 | 56-53 | 5 | 27,009 | Jack Billingham | Dave Rajsich | Jack Billingham | Dave Rajsich | Aurelio Lopez | 529 | 515 | 14 |
| 1979-08-08 | vs TEX | 111 | L 9-16 | 57-54 | 5 | 0 | Pat Underwood | Fergie Jenkins | Fergie Jenkins | Pat Underwood | | 538 | 531 | 7 |
| 1979-08-08 | vs TEX | 112 | W 10-4 | 57-54 | 5 | 28,619 | Bruce Robbins | John Henry Johnson | Bruce Robbins | John Henry Johnson | | 548 | 535 | 13 |
| 1979-08-09 | vs TEX | 113 | W 3-2 | 58-54 | 5 | 23,663 | Mike Chris | Doc Medich | Mike Chris | Doc Medich | Aurelio Lopez | 551 | 537 | 14 |
| 1979-08-10 | @ KCA | 114 | L 6-7 | 58-56 | 5 | 0 | Dan Petry | Rich Gale | Dan Quisenberry | Aurelio Lopez | | 557 | 544 | 13 |
| 1979-08-10 | @ KCA | 115 | L 3-7 | 58-56 | 5 | 37,012 | Pat Underwood | Dennis Leonard | Dennis Leonard | Pat Underwood | Dan Quisenberry | 560 | 551 | 9 |
| 1979-08-11 | @ KCA | 116 | L 5-11 | 58-57 | 5 | 40,255 | Jack Billingham | Paul Splittorff | Paul Splittorff | Jack Billingham | | 565 | 562 | 3 |
| 1979-08-12 | @ KCA | 117 | L 1-7 | 58-58 | 6 | 32,671 | Milt Wilcox | Craig Chamberlain | Craig Chamberlain | Milt Wilcox | | 566 | 569 | -3 |
| 1979-08-13 | @ CAL | 118 | W 5-3 | 59-58 | 6 | 34,032 | Jack Morris | Nolan Ryan | Jack Morris | Nolan Ryan | Aurelio Lopez | 571 | 572 | -1 |
| 1979-08-14 | @ CAL | 119 | W 6-3 | 60-58 | 6 | 29,465 | Bruce Robbins | Don Aase | Bruce Robbins | Don Aase | Jack Billingham | 577 | 575 | 2 |
| 1979-08-15 | @ CAL | 120 | W 6-1 | 61-58 | 5 | 31,885 | Dan Petry | Jim Barr | Dan Petry | Jim Barr | | 583 | 576 | 7 |
| 1979-08-17 | @ SEA | 121 | W 9-2 | 62-58 | 5 | 11,074 | Milt Wilcox | Rick Honeycutt | Milt Wilcox | Rick Honeycutt | John Hiller | 592 | 578 | 14 |
| 1979-08-18 | @ SEA | 122 | W 7-4 | 63-58 | 5 | 14,049 | Jack Morris | Rob Dressler | Jack Morris | Rob Dressler | | 599 | 582 | 17 |
| 1979-08-19 | @ SEA | 123 | L 4-8 | 63-59 | 5 | 7,262 | Bruce Robbins | Floyd Bannister | Floyd Bannister | Bruce Robbins | | 603 | 590 | 13 |
| 1979-08-20 | @ OAK | 124 | W 7-3 | 64-59 | 5 | 5,171 | Dan Petry | Craig Minetto | Dan Petry | Dave Heaverlo | | 610 | 593 | 17 |
| 1979-08-21 | @ OAK | 125 | L 1-8 | 64-60 | 5 | 1,563 | Mike Chris | Brian Kingman | Brian Kingman | Mike Chris | | 611 | 601 | 10 |
| 1979-08-22 | @ OAK | 126 | W 3-1 | 65-60 | 5 | 2,609 | Milt Wilcox | Steve McCatty | Milt Wilcox | Steve McCatty | Aurelio Lopez | 614 | 602 | 12 |
| 1979-08-24 | vs SEA | 127 | W 5-2 | 66-60 | 5 | 26,068 | Jack Morris | Floyd Bannister | Jack Morris | Floyd Bannister | Aurelio Lopez | 619 | 604 | 15 |
| 1979-08-25 | vs SEA | 128 | L 4-8 | 66-61 | 5 | 28,770 | Dan Petry | Mike Parrott | Mike Parrott | Dan Petry | | 623 | 612 | 11 |
| 1979-08-26 | vs SEA | 129 | W 4-3 | 68-61 | 5 | 0 | Mike Chris | Rob Dressler | Aurelio Lopez | Byron McLaughlin | | 627 | 615 | 12 |
| 1979-08-26 | vs SEA | 130 | W 9-8 | 68-61 | 5 | 31,770 | Pat Underwood | Shane Rawley | Dave Tobik | Randy Stein | | 636 | 623 | 13 |
| 1979-08-27 | vs CAL | 131 | W 3-2 | 69-61 | 5 | 22,874 | Jack Billingham | Jim Barr | Jack Billingham | Jim Barr | Aurelio Lopez | 639 | 625 | 14 |
| 1979-08-28 | vs CAL | 132 | W 12-2 | 70-61 | 5 | 19,178 | Bruce Robbins | Don Aase | Bruce Robbins | Don Aase | | 651 | 627 | 24 |
| 1979-08-29 | vs CAL | 133 | W 2-1 | 71-61 | 5 | 19,880 | Jack Morris | Dave Frost | Jack Morris | Dave Frost | Aurelio Lopez | 653 | 628 | 25 |
| 1979-08-30 | vs OAK | 134 | W 8-7 | 72-61 | 5 | 12,870 | Dan Petry | Craig Minetto | Dave Tobik | Craig Minetto | | 661 | 635 | 26 |
| 1979-08-31 | vs OAK | 135 | L 3-5 | 72-62 | 5 | 18,454 | Milt Wilcox | Brian Kingman | Brian Kingman | Dave Tobik | Dave Hamilton | 664 | 640 | 24 |
| 1979-09-01 | vs OAK | 136 | L 3-6 | 72-63 | 5 | 15,235 | Jack Billingham | Steve McCatty | Steve McCatty | Aurelio Lopez | Dave Hamilton | 667 | 646 | 21 |
| 1979-09-02 | vs OAK | 137 | L 4-5 | 72-64 | 5 | 14,379 | Bruce Robbins | Rick Langford | Rick Langford | Bruce Robbins | | 671 | 651 | 20 |
| 1979-09-03 | @ CLE | 138 | L 3-4 | 72-65 | 5 | 9,095 | Jack Morris | Rick Wise | Rick Wise | Jack Morris | | 674 | 655 | 19 |
| 1979-09-04 | @ CLE | 139 | L 3-5 | 72-66 | 5 | 4,824 | Dan Petry | Len Barker | Len Barker | Dan Petry | Sid Monge | 677 | 660 | 17 |
| 1979-09-05 | @ CLE | 140 | W 9-3 | 73-66 | 5 | 5,172 | Dave Rozema | Dan Spillner | Aurelio Lopez | Victor Cruz | | 686 | 663 | 23 |
| 1979-09-06 | vs NYA | 141 | L 1-3 | 73-67 | 5 | 19,196 | Milt Wilcox | Don Hood | Rich Gossage | Milt Wilcox | | 687 | 666 | 21 |
| 1979-09-07 | vs NYA | 142 | W 6-0 | 74-67 | 5 | 28,943 | Bruce Robbins | Ken Clay | Jack Billingham | Ken Clay | | 693 | 666 | 27 |
| 1979-09-08 | vs NYA | 143 | L 4-5 | 74-68 | 5 | 30,069 | Jack Morris | Ron Guidry | Ron Guidry | Jack Morris | Rich Gossage | 697 | 671 | 26 |
| 1979-09-09 | vs NYA | 144 | W 3-1 | 75-68 | 5 | 30,836 | Mike Chris | Tommy John | Mike Chris | Tommy John | Aurelio Lopez | 700 | 672 | 28 |
| 1979-09-11 | vs CLE | 145 | W 14-1 | 76-68 | 5 | 7,983 | Dave Rozema | Dan Spillner | Dave Rozema | Dan Spillner | | 714 | 673 | 41 |
| 1979-09-12 | vs CLE | 146 | W 4-1 | 77-68 | 5 | 8,517 | Milt Wilcox | Rick Waits | Milt Wilcox | Rick Waits | Aurelio Lopez | 718 | 674 | 44 |
| 1979-09-15 | @ NYA | 147 | W 4-3 | 78-69 | 5 | 0 | Jack Morris | Tommy John | Jack Morris | Tommy John | Aurelio Lopez | 722 | 677 | 45 |
| 1979-09-15 | @ NYA | 148 | L 1-7 | 78-69 | 5 | 30,050 | Mike Chris | Don Hood | Ron Davis | Mike Chris | Jim Kaat | 723 | 684 | 39 |
| 1979-09-16 | @ NYA | 149 | W 8-4 | 79-69 | 5 | 40,192 | Dave Rozema | Dave Righetti | Aurelio Lopez | Rich Gossage | | 731 | 688 | 43 |
| 1979-09-17 | vs BAL | 150 | L 1-2 | 79-70 | 5 | 12,918 | Milt Wilcox | Scott McGregor | Scott McGregor | Milt Wilcox | | 732 | 690 | 42 |
| 1979-09-18 | vs BAL | 151 | W 2-1 | 80-70 | 5 | 13,586 | Dan Petry | Mike Flanagan | Dan Petry | Mike Flanagan | Aurelio Lopez | 734 | 691 | 43 |
| 1979-09-19 | vs BAL | 152 | W 5-0 | 81-70 | 5 | 12,573 | Jack Morris | Dennis Martinez | Jack Morris | Dennis Martinez | | 739 | 691 | 48 |
| 1979-09-20 | vs BAL | 153 | L 7-8 | 81-71 | 5 | 10,024 | Mike Chris | Steve Stone | Tippy Martinez | Jack Billingham | Don Stanhouse | 746 | 699 | 47 |
| 1979-09-21 | @ BOS | 154 | L 1-4 | 81-72 | 5 | 24,802 | Dave Rozema | John Tudor | John Tudor | Dave Rozema | | 747 | 703 | 44 |
| 1979-09-23 | @ BOS | 155 | L 1-2 | 82-73 | 5 | 0 | Milt Wilcox | Dennis Eckersley | Dennis Eckersley | Milt Wilcox | | 748 | 705 | 43 |
| 1979-09-23 | @ BOS | 156 | W 3-2 | 82-73 | 5 | 31,871 | Dan Petry | Mike Torrez | Aurelio Lopez | Mike Torrez | | 751 | 707 | 44 |
| 1979-09-25 | @ BAL | 157 | W 3-2 | 83-73 | 5 | 12,543 | Jack Morris | Steve Stone | Jack Morris | Tippy Martinez | Aurelio Lopez | 754 | 709 | 45 |
| 1979-09-26 | @ BAL | 158 | L 2-13 | 83-74 | 5 | 17,205 | Mike Chris | Scott McGregor | Scott McGregor | Mike Chris | | 756 | 722 | 34 |
| 1979-09-28 | vs BOS | 159 | L 4-7 | 83-75 | 5 | 17,846 | Milt Wilcox | Mike Torrez | Mike Torrez | Milt Wilcox | Tom Burgmeier | 760 | 729 | 31 |
| 1979-09-29 | vs BOS | 160 | L 5-8 | 83-76 | 5 | 19,907 | Dan Petry | Steve Renko | Steve Renko | Aurelio Lopez | Dick Drago | 765 | 737 | 28 |
| 1979-09-30 | vs BOS | 161 | W 5-1 | 84-76 | 5 | 20,167 | Jack Morris | Bob Stanley | Jack Morris | Bob Stanley | | 770 | 738 | 32 |