| 1978-04-06 | vs HOU | 1 | W 11-9 | 1-0 | 1 | 52,378 | Tom Seaver | J.R. Richard | Pedro Borbon | J.R. Richard | Dave Tomlin | 11 | 9 | 2 |
| 1978-04-07 | vs HOU | 2 | W 5-4 | 2-0 | 1 | 22,883 | Bill Bonham | Joe Niekro | Bill Bonham | Joe Niekro | Pedro Borbon | 16 | 13 | 3 |
| 1978-04-08 | vs HOU | 3 | W 2-1 | 3-0 | 1 | 17,958 | Fred Norman | Joaquin Andujar | Fred Norman | Joaquin Andujar | Doug Bair | 18 | 14 | 4 |
| 1978-04-09 | vs HOU | 4 | W 9-3 | 4-0 | 1 | 42,667 | Tom Hume | Mark Lemongello | Tom Hume | Mark Lemongello | | 27 | 17 | 10 |
| 1978-04-11 | vs SFN | 5 | L 2-3 | 4-1 | 1 | 16,134 | Tom Seaver | Bob Knepper | Gary Lavelle | Dave Tomlin | | 29 | 20 | 9 |
| 1978-04-12 | vs SFN | 6 | W 12-3 | 5-1 | 1 | 17,123 | Bill Bonham | Vida Blue | Bill Bonham | Vida Blue | | 41 | 23 | 18 |
| 1978-04-13 | vs SFN | 7 | W 7-6 | 6-1 | 1 | 19,309 | Fred Norman | John Montefusco | Manny Sarmiento | John Curtis | | 48 | 29 | 19 |
| 1978-04-14 | @ HOU | 8 | W 8-4 | 7-1 | 1 | 25,583 | Tom Hume | Joaquin Andujar | Tom Hume | Joaquin Andujar | Dale Murray | 56 | 33 | 23 |
| 1978-04-15 | @ HOU | 9 | L 1-6 | 7-2 | 1 | 34,858 | Doug Capilla | Mark Lemongello | Mark Lemongello | Doug Capilla | | 57 | 39 | 18 |
| 1978-04-16 | @ HOU | 10 | L 3-4 | 7-3 | 2 | 27,700 | Tom Seaver | J.R. Richard | Tom Dixon | Manny Sarmiento | | 60 | 43 | 17 |
| 1978-04-17 | @ LAN | 11 | W 8-2 | 8-3 | 1 | 40,527 | Bill Bonham | Burt Hooton | Bill Bonham | Burt Hooton | | 68 | 45 | 23 |
| 1978-04-18 | @ LAN | 12 | W 11-3 | 9-3 | 1 | 50,374 | Fred Norman | Don Sutton | Fred Norman | Don Sutton | Dale Murray | 79 | 48 | 31 |
| 1978-04-19 | @ LAN | 13 | L 4-5 | 9-4 | 1 | 49,333 | Tom Hume | Tommy John | Tommy John | Tom Hume | | 83 | 53 | 30 |
| 1978-04-21 | @ SFN | 14 | L 0-3 | 9-5 | 1 | 26,576 | Tom Seaver | Bob Knepper | Bob Knepper | Tom Seaver | | 83 | 56 | 27 |
| 1978-04-22 | @ SFN | 15 | W 5-4 | 10-5 | 1 | 24,677 | Doug Capilla | Vida Blue | Dave Tomlin | Gary Lavelle | | 88 | 60 | 28 |
| 1978-04-23 | @ SFN | 16 | W 2-1 | 11-5 | 1 | 50,510 | Fred Norman | John Montefusco | Dale Murray | Randy Moffitt | Doug Bair | 90 | 61 | 29 |
| 1978-04-25 | vs LAN | 17 | L 2-4 | 11-6 | 2 | 27,361 | Tom Hume | Tommy John | Tommy John | Tom Hume | | 92 | 65 | 27 |
| 1978-04-26 | vs LAN | 18 | L 4-14 | 11-7 | 2 | 32,872 | Tom Seaver | Doug Rau | Doug Rau | Tom Seaver | | 96 | 79 | 17 |
| 1978-04-28 | @ NYN | 19 | W 5-1 | 12-7 | 2 | 15,842 | Fred Norman | Jerry Koosman | Fred Norman | Jerry Koosman | Manny Sarmiento | 101 | 80 | 21 |
| 1978-04-29 | @ NYN | 20 | W 14-7 | 13-7 | 2 | 17,347 | Doug Capilla | Nino Espinosa | Pedro Borbon | Mardie Cornejo | Doug Bair | 115 | 87 | 28 |
| 1978-04-30 | @ NYN | 21 | L 4-6 | 13-8 | 2 | 20,092 | Tom Hume | Pat Zachry | Pat Zachry | Tom Hume | Skip Lockwood | 119 | 93 | 26 |
| 1978-05-01 | vs PHI | 22 | L 1-12 | 13-9 | 2 | 21,476 | Tom Seaver | Steve Carlton | Steve Carlton | Tom Seaver | | 120 | 105 | 15 |
| 1978-05-03 | vs PHI | 23 | W 12-3 | 14-9 | 2 | 26,054 | Fred Norman | Larry Christenson | Fred Norman | Larry Christenson | | 132 | 108 | 24 |
| 1978-05-05 | vs MON | 24 | L 3-4 | 14-10 | 2 | 37,823 | Tom Hume | Steve Rogers | Steve Rogers | Tom Hume | | 135 | 112 | 23 |
| 1978-05-06 | vs MON | 25 | W 6-2 | 15-10 | 2 | 50,142 | Tom Seaver | Rudy May | Tom Seaver | Rudy May | Pedro Borbon | 141 | 114 | 27 |
| 1978-05-07 | vs MON | 26 | L 5-19 | 16-11 | 2 | 0 | Paul Moskau | Wayne Twitchell | Wayne Twitchell | Paul Moskau | | 146 | 133 | 13 |
| 1978-05-07 | vs MON | 27 | W 4-2 | 16-11 | 2 | 35,037 | Manny Sarmiento | Ross Grimsley | Manny Sarmiento | Ross Grimsley | Doug Bair | 150 | 135 | 15 |
| 1978-05-08 | vs NYN | 28 | L 2-3 | 16-12 | 2 | 16,094 | Fred Norman | Mike Bruhert | Skip Lockwood | Pedro Borbon | Mardie Cornejo | 152 | 138 | 14 |
| 1978-05-09 | vs NYN | 29 | W 7-6 | 17-12 | 2 | 19,217 | Tom Hume | Jerry Koosman | Doug Bair | Skip Lockwood | | 159 | 144 | 15 |
| 1978-05-11 | @ PHI | 30 | L 1-4 | 17-13 | 3 | 32,580 | Tom Seaver | Steve Carlton | Steve Carlton | Tom Seaver | | 160 | 148 | 12 |
| 1978-05-12 | @ PHI | 31 | W 3-0 | 18-13 | 2 | 38,179 | Bill Bonham | Randy Lerch | Bill Bonham | Randy Lerch | Paul Moskau | 163 | 148 | 15 |
| 1978-05-13 | @ PHI | 32 | W 4-3 | 19-13 | 2 | 35,802 | Fred Norman | Jim Kaat | Manny Sarmiento | Tug McGraw | | 167 | 151 | 16 |
| 1978-05-14 | @ PHI | 33 | L 4-7 | 19-14 | 2 | 30,482 | Tom Hume | Larry Christenson | Larry Christenson | Tom Hume | Ron Reed | 171 | 158 | 13 |
| 1978-05-16 | @ MON | 34 | W 5-1 | 20-14 | 2 | 10,725 | Tom Seaver | Wayne Twitchell | Tom Seaver | Wayne Twitchell | | 176 | 159 | 17 |
| 1978-05-17 | @ MON | 35 | L 4-5 | 20-15 | 3 | 11,826 | Bill Bonham | Ross Grimsley | Darold Knowles | Dale Murray | | 180 | 164 | 16 |
| 1978-05-18 | @ MON | 36 | W 3-2 | 21-15 | 3 | 9,435 | Fred Norman | Steve Rogers | Fred Norman | Steve Rogers | Pedro Borbon | 183 | 166 | 17 |
| 1978-05-19 | vs SDN | 37 | W 4-3 | 22-15 | 2 | 36,283 | Paul Moskau | Randy Jones | Dave Tomlin | Rollie Fingers | Doug Bair | 187 | 169 | 18 |
| 1978-05-20 | vs SDN | 38 | W 10-6 | 23-15 | 2 | 35,429 | Tom Hume | Gaylord Perry | Dave Tomlin | Rollie Fingers | | 197 | 175 | 22 |
| 1978-05-21 | vs SDN | 39 | L 2-7 | 24-16 | 3 | 0 | Manny Sarmiento | Bob Shirley | Bob Shirley | Manny Sarmiento | | 199 | 182 | 17 |
| 1978-05-21 | vs SDN | 40 | W 1-0 | 24-16 | 3 | 38,295 | Tom Seaver | John D'Acquisto | Tom Seaver | John D'Acquisto | Doug Bair | 200 | 182 | 18 |
| 1978-05-22 | vs ATL | 41 | W 10-0 | 25-16 | 3 | 18,434 | Bill Bonham | Mickey Mahler | Bill Bonham | Mickey Mahler | | 210 | 182 | 28 |
| 1978-05-23 | vs ATL | 42 | L 4-6 | 25-17 | 3 | 17,771 | Fred Norman | Preston Hanna | Preston Hanna | Fred Norman | Adrian Devine | 214 | 188 | 26 |
| 1978-05-24 | vs ATL | 43 | W 5-4 | 26-17 | 2 | 23,891 | Paul Moskau | Jamie Easterly | Manny Sarmiento | Adrian Devine | | 219 | 192 | 27 |
| 1978-05-26 | @ SDN | 44 | W 3-1 | 27-17 | 2 | 34,227 | Tom Seaver | Bob Shirley | Tom Seaver | Bob Shirley | Doug Bair | 222 | 193 | 29 |
| 1978-05-27 | @ SDN | 45 | W 5-2 | 28-17 | 2 | 43,484 | Bill Bonham | Bob Owchinko | Bill Bonham | Bob Owchinko | | 227 | 195 | 32 |
| 1978-05-28 | @ SDN | 46 | L 1-3 | 28-18 | 2 | 34,029 | Fred Norman | Randy Jones | Randy Jones | Fred Norman | Rollie Fingers | 228 | 198 | 30 |
| 1978-05-29 | @ ATL | 47 | W 7-5 | 29-18 | 2 | 12,569 | Paul Moskau | Mickey Mahler | Manny Sarmiento | Jamie Easterly | Doug Bair | 235 | 203 | 32 |
| 1978-05-30 | @ ATL | 48 | L 3-4 | 29-19 | 2 | 10,103 | Tom Hume | Phil Niekro | Jamie Easterly | Doug Bair | | 238 | 207 | 31 |
| 1978-05-31 | @ ATL | 49 | W 10-4 | 30-19 | 2 | 10,933 | Tom Seaver | Dick Ruthven | Tom Seaver | Dick Ruthven | | 248 | 211 | 37 |
| 1978-06-02 | vs PIT | 50 | W 3-2 | 31-19 | 2 | 40,495 | Bill Bonham | Jim Rooker | Dave Tomlin | Jim Rooker | | 251 | 213 | 38 |
| 1978-06-03 | vs PIT | 51 | W 4-3 | 32-19 | 2 | 50,152 | Fred Norman | Don Robinson | Fred Norman | Don Robinson | Manny Sarmiento | 255 | 216 | 39 |
| 1978-06-04 | vs PIT | 52 | L 1-4 | 32-20 | 2 | 37,304 | Paul Moskau | Bert Blyleven | Bert Blyleven | Paul Moskau | Grant Jackson | 256 | 220 | 36 |
| 1978-06-05 | @ SLN | 53 | W 2-1 | 33-20 | 2 | 32,057 | Tom Seaver | Bob Forsch | Tom Seaver | Bob Forsch | | 258 | 221 | 37 |
| 1978-06-06 | @ SLN | 54 | L 1-4 | 33-21 | 2 | 17,274 | Tom Hume | John Denny | John Denny | Tom Hume | | 259 | 225 | 34 |
| 1978-06-07 | @ CHN | 55 | W 9-6 | 34-21 | 1 | 21,093 | Bill Bonham | Ray Burris | Bill Bonham | Ray Burris | Doug Bair | 268 | 231 | 37 |
| 1978-06-08 | @ CHN | 56 | L 1-10 | 34-22 | 2 | 21,137 | Fred Norman | Rick Reuschel | Rick Reuschel | Fred Norman | | 269 | 241 | 28 |
| 1978-06-09 | @ PIT | 57 | L 9-11 | 34-23 | 2 | 21,710 | Paul Moskau | Don Robinson | Grant Jackson | Doug Bair | John Candelaria | 278 | 252 | 26 |
| 1978-06-10 | @ PIT | 58 | W 6-4 | 35-23 | 2 | 34,009 | Tom Seaver | Bert Blyleven | Tom Seaver | Grant Jackson | | 284 | 256 | 28 |
| 1978-06-11 | @ PIT | 59 | L 1-3 | 35-24 | 2 | 24,972 | Tom Hume | Jim Rooker | Grant Jackson | Manny Sarmiento | Ed Whitson | 285 | 259 | 26 |
| 1978-06-12 | vs CHN | 60 | L 2-3 | 35-25 | 2 | 30,190 | Bill Bonham | Rick Reuschel | Rick Reuschel | Bill Bonham | Ken Holtzman | 287 | 262 | 25 |
| 1978-06-13 | vs CHN | 61 | W 1-0 | 36-25 | 2 | 31,283 | Fred Norman | Dennis Lamp | Fred Norman | Dennis Lamp | Doug Bair | 288 | 262 | 26 |
| 1978-06-14 | vs CHN | 62 | W 3-1 | 37-25 | 2 | 34,658 | Manny Sarmiento | Dave Roberts | Manny Sarmiento | Dave Roberts | Doug Bair | 291 | 263 | 28 |
| 1978-06-16 | vs SLN | 63 | W 4-0 | 38-25 | 2 | 38,216 | Tom Seaver | John Denny | Tom Seaver | John Denny | | 295 | 263 | 32 |
| 1978-06-17 | vs SLN | 64 | W 6-5 | 39-25 | 2 | 40,262 | Bill Bonham | Pete Vuckovich | Pedro Borbon | Buddy Schultz | | 301 | 268 | 33 |
| 1978-06-18 | vs SLN | 65 | W 4-2 | 40-25 | 2 | 40,016 | Fred Norman | Silvio Martinez | Fred Norman | Silvio Martinez | Manny Sarmiento | 305 | 270 | 35 |
| 1978-06-20 | @ SFN | 66 | W 6-3 | 41-25 | 2 | 55,920 | Paul Moskau | John Montefusco | Pedro Borbon | Gary Lavelle | Dave Tomlin | 311 | 273 | 38 |
| 1978-06-21 | @ SFN | 67 | L 0-3 | 41-26 | 2 | 37,334 | Tom Seaver | Ed Halicki | Ed Halicki | Tom Seaver | | 311 | 276 | 35 |
| 1978-06-22 | @ SFN | 68 | W 5-0 | 42-26 | 2 | 40,039 | Bill Bonham | Bob Knepper | Bill Bonham | Bob Knepper | Manny Sarmiento | 316 | 276 | 40 |
| 1978-06-23 | @ LAN | 69 | L 0-1 | 42-27 | 2 | 51,068 | Fred Norman | Burt Hooton | Burt Hooton | Fred Norman | | 316 | 277 | 39 |
| 1978-06-24 | @ LAN | 70 | L 3-4 | 42-28 | 2 | 46,274 | Tom Hume | Don Sutton | Don Sutton | Tom Hume | Bob Welch | 319 | 281 | 38 |
| 1978-06-25 | @ LAN | 71 | W 5-4 | 43-28 | 2 | 50,356 | Paul Moskau | Tommy John | Pedro Borbon | Tommy John | Doug Bair | 324 | 285 | 39 |
| 1978-06-26 | @ HOU | 72 | W 4-3 | 44-28 | 2 | 20,388 | Tom Seaver | Mark Lemongello | Tom Seaver | Mark Lemongello | Dave Tomlin | 328 | 288 | 40 |
| 1978-06-27 | @ HOU | 73 | L 4-7 | 44-29 | 2 | 16,848 | Bill Bonham | Joe Niekro | Joe Niekro | Bill Bonham | Joe Sambito | 332 | 295 | 37 |
| 1978-06-28 | @ HOU | 74 | L 0-3 | 44-30 | 2 | 16,622 | Fred Norman | Tom Dixon | Tom Dixon | Fred Norman | | 332 | 298 | 34 |
| 1978-06-29 | @ HOU | 75 | L 0-5 | 44-31 | 2 | 17,564 | Tom Hume | Floyd Bannister | Floyd Bannister | Tom Hume | | 332 | 303 | 29 |
| 1978-06-30 | vs LAN | 76 | L 3-5 | 44-33 | 3 | 0 | Paul Moskau | Tommy John | Tommy John | Doug Bair | Lance Rautzhan | 335 | 308 | 27 |
| 1978-06-30 | vs LAN | 77 | L 2-5 | 44-33 | 3 | 50,370 | Manny Sarmiento | Bob Welch | Bob Welch | Manny Sarmiento | Charlie Hough | 337 | 313 | 24 |
| 1978-07-01 | vs LAN | 78 | L 0-2 | 44-34 | 3 | 48,044 | Tom Seaver | Rick Rhoden | Rick Rhoden | Tom Seaver | | 337 | 315 | 22 |
| 1978-07-02 | vs LAN | 79 | W 7-6 | 45-34 | 3 | 46,067 | Bill Bonham | Doug Rau | Doug Bair | Doug Rau | | 344 | 321 | 23 |
| 1978-07-03 | vs HOU | 80 | W 8-7 | 46-34 | 2 | 31,840 | Fred Norman | Floyd Bannister | Doug Bair | Joe Sambito | | 352 | 328 | 24 |
| 1978-07-04 | vs HOU | 81 | L 1-3 | 46-35 | 3 | 31,705 | Tom Hume | J.R. Richard | J.R. Richard | Tom Hume | | 353 | 331 | 22 |
| 1978-07-05 | vs HOU | 82 | W 2-1 | 47-35 | 2 | 30,320 | Paul Moskau | Joe Niekro | Paul Moskau | Joe Niekro | Doug Bair | 355 | 332 | 23 |
| 1978-07-07 | vs SFN | 83 | L 6-7 | 48-36 | 3 | 0 | Tom Seaver | Vida Blue | Vida Blue | Tom Seaver | Gary Lavelle | 361 | 339 | 22 |
| 1978-07-07 | vs SFN | 84 | W 2-1 | 48-36 | 3 | 51,163 | Bill Bonham | Jim Barr | Bill Bonham | Jim Barr | Doug Bair | 363 | 340 | 23 |
| 1978-07-08 | vs SFN | 85 | L 2-4 | 48-37 | 3 | 43,316 | Fred Norman | John Montefusco | Gary Lavelle | Manny Sarmiento | | 365 | 344 | 21 |
| 1978-07-09 | vs SFN | 86 | W 8-2 | 49-37 | 3 | 37,966 | Paul Moskau | Ed Halicki | Tom Hume | Ed Halicki | Dave Tomlin | 373 | 346 | 27 |
| 1978-07-13 | vs NYN | 87 | L 2-4 | 49-38 | 3 | 35,226 | Tom Seaver | Jerry Koosman | Jerry Koosman | Tom Seaver | Skip Lockwood | 375 | 350 | 25 |
| 1978-07-14 | vs NYN | 88 | W 6-3 | 50-38 | 2 | 34,751 | Fred Norman | Pat Zachry | Doug Bair | Pat Zachry | | 381 | 353 | 28 |
| 1978-07-15 | vs NYN | 89 | W 7-5 | 51-38 | 2 | 50,125 | Paul Moskau | Craig Swan | Dave Tomlin | Dale Murray | Manny Sarmiento | 388 | 358 | 30 |
| 1978-07-16 | vs NYN | 90 | W 9-2 | 52-38 | 2 | 33,519 | Tom Hume | Kevin Kobel | Tom Hume | Kevin Kobel | | 397 | 360 | 37 |
| 1978-07-17 | vs MON | 91 | W 8-6 | 53-38 | 2 | 32,113 | Fred Norman | Ross Grimsley | Manny Sarmiento | Stan Bahnsen | Doug Bair | 405 | 366 | 39 |
| 1978-07-18 | vs MON | 92 | L 1-3 | 53-39 | 3 | 36,739 | Tom Seaver | Hal Dues | Hal Dues | Tom Seaver | Mike Garman | 406 | 369 | 37 |
| 1978-07-19 | @ PHI | 93 | W 7-2 | 54-39 | 2 | 45,608 | Paul Moskau | Steve Carlton | Dave Tomlin | Steve Carlton | Doug Bair | 413 | 371 | 42 |
| 1978-07-20 | @ PHI | 94 | L 6-8 | 54-40 | 2 | 44,054 | Tom Hume | Jim Kaat | Warren Brusstar | Manny Sarmiento | Tug McGraw | 419 | 379 | 40 |
| 1978-07-21 | @ MON | 95 | W 10-3 | 55-40 | 2 | 25,825 | Mike LaCoss | Ross Grimsley | Mike LaCoss | Ross Grimsley | | 429 | 382 | 47 |
| 1978-07-22 | @ MON | 96 | W 2-1 | 56-40 | 2 | 28,920 | Fred Norman | Dan Schatzeder | Fred Norman | Dan Schatzeder | Doug Bair | 431 | 383 | 48 |
| 1978-07-23 | @ MON | 97 | W 5-4 | 57-40 | 2 | 28,391 | Tom Seaver | Steve Rogers | Manny Sarmiento | Wayne Twitchell | Pedro Borbon | 436 | 387 | 49 |
| 1978-07-24 | @ NYN | 98 | W 5-3 | 58-40 | 2 | 35,939 | Paul Moskau | Pat Zachry | Manny Sarmiento | Skip Lockwood | | 441 | 390 | 51 |
| 1978-07-25 | @ NYN | 99 | L 2-9 | 58-41 | 2 | 38,158 | Tom Hume | Craig Swan | Craig Swan | Tom Hume | | 443 | 399 | 44 |
| 1978-07-26 | @ NYN | 100 | L 3-12 | 58-42 | 3 | 19,892 | Mike LaCoss | Nino Espinosa | Nino Espinosa | Mike LaCoss | | 446 | 411 | 35 |
| 1978-07-28 | vs PHI | 101 | L 2-12 | 59-43 | 3 | 0 | Fred Norman | Randy Lerch | Randy Lerch | Fred Norman | | 448 | 423 | 25 |
| 1978-07-28 | vs PHI | 102 | W 2-1 | 59-43 | 3 | 51,779 | Tom Seaver | Steve Carlton | Tom Seaver | Steve Carlton | Doug Bair | 450 | 424 | 26 |
| 1978-07-29 | vs PHI | 103 | W 6-2 | 60-43 | 3 | 49,108 | Paul Moskau | Jim Lonborg | Paul Moskau | Jim Lonborg | | 456 | 426 | 30 |
| 1978-07-30 | vs PHI | 104 | W 5-3 | 61-43 | 2 | 44,092 | Tom Hume | Larry Christenson | Tom Hume | Larry Christenson | Doug Bair | 461 | 429 | 32 |
| 1978-07-31 | @ ATL | 105 | W 3-2 | 62-43 | 2 | 45,007 | Mike LaCoss | Phil Niekro | Mike LaCoss | Phil Niekro | Doug Bair | 464 | 431 | 33 |
| 1978-08-01 | @ ATL | 106 | L 4-16 | 62-44 | 2 | 31,159 | Fred Norman | Larry McWilliams | Larry McWilliams | Pedro Borbon | Gene Garber | 468 | 447 | 21 |
| 1978-08-02 | @ ATL | 107 | W 6-2 | 63-44 | 2 | 26,812 | Tom Seaver | Preston Hanna | Tom Seaver | Preston Hanna | | 474 | 449 | 25 |
| 1978-08-04 | vs SDN | 108 | L 2-3 | 63-45 | 2 | 44,829 | Paul Moskau | Gaylord Perry | Bob Shirley | Doug Bair | Rollie Fingers | 476 | 452 | 24 |
| 1978-08-05 | vs SDN | 109 | W 7-1 | 64-45 | 2 | 40,202 | Mike LaCoss | Eric Rasmussen | Mike LaCoss | Eric Rasmussen | | 483 | 453 | 30 |
| 1978-08-06 | vs SDN | 110 | W 3-1 | 65-45 | 1 | 39,263 | Bill Bonham | Randy Jones | Fred Norman | Randy Jones | Doug Bair | 486 | 454 | 32 |
| 1978-08-07 | vs ATL | 111 | L 3-5 | 65-46 | 2 | 33,215 | Tom Seaver | Mickey Mahler | Mickey Mahler | Tom Seaver | Gene Garber | 489 | 459 | 30 |
| 1978-08-08 | vs ATL | 112 | L 5-6 | 65-47 | 2 | 32,730 | Tom Hume | Phil Niekro | Phil Niekro | Tom Hume | | 494 | 465 | 29 |
| 1978-08-09 | vs ATL | 113 | W 10-0 | 66-47 | 2 | 34,090 | Paul Moskau | Tommy Boggs | Paul Moskau | Tommy Boggs | | 504 | 465 | 39 |
| 1978-08-10 | @ SDN | 114 | L 3-15 | 66-48 | 3 | 27,882 | Mike LaCoss | Randy Jones | Randy Jones | Mike LaCoss | Bob Shirley | 507 | 480 | 27 |
| 1978-08-11 | @ SDN | 115 | W 2-0 | 67-48 | 2 | 33,635 | Bill Bonham | Bob Owchinko | Doug Bair | Bob Owchinko | | 509 | 480 | 29 |
| 1978-08-12 | @ SDN | 116 | L 2-4 | 67-49 | 3 | 38,543 | Tom Seaver | Gaylord Perry | Gaylord Perry | Tom Seaver | Rollie Fingers | 511 | 484 | 27 |
| 1978-08-13 | @ SDN | 117 | L 2-3 | 67-50 | 3 | 34,267 | Fred Norman | Eric Rasmussen | Eric Rasmussen | Fred Norman | Bob Shirley | 513 | 487 | 26 |
| 1978-08-14 | @ PIT | 118 | L 4-7 | 67-51 | 3 | 26,514 | Paul Moskau | Jim Rooker | Jim Rooker | Paul Moskau | Kent Tekulve | 517 | 494 | 23 |
| 1978-08-15 | @ PIT | 119 | W 4-3 | 68-51 | 3 | 16,400 | Mike LaCoss | Bert Blyleven | Doug Bair | Ed Whitson | | 521 | 497 | 24 |
| 1978-08-16 | @ PIT | 120 | L 2-13 | 68-52 | 3 | 15,490 | Bill Bonham | John Candelaria | John Candelaria | Bill Bonham | Grant Jackson | 523 | 510 | 13 |
| 1978-08-17 | @ CHN | 121 | L 0-2 | 68-53 | 3 | 36,814 | Tom Seaver | Rick Reuschel | Rick Reuschel | Tom Seaver | | 523 | 512 | 11 |
| 1978-08-18 | @ CHN | 122 | W 8-3 | 69-53 | 3 | 33,416 | Fred Norman | Dave Roberts | Pedro Borbon | Dave Roberts | Tom Hume | 531 | 515 | 16 |
| 1978-08-19 | @ CHN | 123 | W 9-7 | 70-53 | 3 | 38,740 | Paul Moskau | Dennis Lamp | Tom Hume | Bruce Sutter | | 540 | 522 | 18 |
| 1978-08-20 | @ CHN | 124 | L 1-2 | 70-54 | 3 | 39,242 | Mike LaCoss | Ray Burris | Guillermo Hernandez | Mike LaCoss | | 541 | 524 | 17 |
| 1978-08-21 | vs SLN | 125 | L 9-14 | 70-55 | 3 | 30,548 | Bill Bonham | Silvio Martinez | Silvio Martinez | Bill Bonham | | 550 | 538 | 12 |
| 1978-08-22 | vs SLN | 126 | W 5-4 | 71-55 | 3 | 31,182 | Tom Seaver | John Denny | Dave Tomlin | Tom Bruno | | 555 | 542 | 13 |
| 1978-08-24 | vs SLN | 127 | L 3-4 | 71-56 | 3 | 30,054 | Paul Moskau | Pete Vuckovich | Pete Vuckovich | Paul Moskau | | 558 | 546 | 12 |
| 1978-08-25 | vs CHN | 128 | L 2-5 | 71-57 | 3 | 39,070 | Mike LaCoss | Rick Reuschel | Rick Reuschel | Mike LaCoss | | 560 | 551 | 9 |
| 1978-08-26 | vs CHN | 129 | L 6-8 | 71-58 | 3 | 47,299 | Bill Bonham | Ray Burris | Dave Roberts | Doug Bair | Bruce Sutter | 566 | 559 | 7 |
| 1978-08-27 | vs CHN | 130 | L 1-7 | 71-59 | 3 | 40,014 | Tom Seaver | Mike Krukow | Mike Krukow | Tom Seaver | | 567 | 566 | 1 |
| 1978-08-28 | vs PIT | 131 | L 1-3 | 71-60 | 3 | 23,612 | Fred Norman | John Candelaria | John Candelaria | Fred Norman | Ed Whitson | 568 | 569 | -1 |
| 1978-08-29 | vs PIT | 132 | L 0-5 | 71-61 | 3 | 24,967 | Mike LaCoss | Bert Blyleven | Bert Blyleven | Mike LaCoss | | 568 | 574 | -6 |
| 1978-08-31 | @ SLN | 133 | W 11-6 | 72-61 | 3 | 16,112 | Tom Seaver | Silvio Martinez | Tom Seaver | Silvio Martinez | | 579 | 580 | -1 |
| 1978-09-01 | @ SLN | 134 | W 5-2 | 73-61 | 3 | 17,257 | Paul Moskau | John Denny | Paul Moskau | John Denny | Doug Bair | 584 | 582 | 2 |
| 1978-09-02 | @ SLN | 135 | W 6-3 | 74-61 | 3 | 20,336 | Fred Norman | Pete Vuckovich | Pedro Borbon | Mark Littell | Doug Bair | 590 | 585 | 5 |
| 1978-09-03 | @ SLN | 136 | L 2-10 | 74-62 | 3 | 22,051 | Mike LaCoss | Pete Falcone | Pete Falcone | Mike LaCoss | | 592 | 595 | -3 |
| 1978-09-04 | @ HOU | 137 | W 6-3 | 75-62 | 3 | 11,090 | Bill Bonham | Joe Niekro | Bill Bonham | Joe Niekro | Doug Bair | 598 | 598 | 0 |
| 1978-09-05 | @ HOU | 138 | L 2-3 | 75-63 | 3 | 8,811 | Tom Seaver | J.R. Richard | J.R. Richard | Tom Seaver | | 600 | 601 | -1 |
| 1978-09-07 | vs SDN | 139 | W 6-2 | 76-63 | 3 | 20,611 | Paul Moskau | Bob Owchinko | Paul Moskau | Bob Owchinko | Fred Norman | 606 | 603 | 3 |
| 1978-09-08 | vs SDN | 140 | L 2-3 | 76-64 | 3 | 27,205 | Mike LaCoss | Gaylord Perry | Gaylord Perry | Mike LaCoss | Rollie Fingers | 608 | 606 | 2 |
| 1978-09-09 | vs SFN | 141 | W 6-3 | 77-64 | 3 | 47,091 | Bill Bonham | Bob Knepper | Bill Bonham | Bob Knepper | Doug Bair | 614 | 609 | 5 |
| 1978-09-10 | vs SFN | 142 | W 8-1 | 78-64 | 3 | 43,779 | Tom Seaver | Ed Halicki | Tom Seaver | Ed Halicki | Doug Bair | 622 | 610 | 12 |
| 1978-09-11 | vs HOU | 143 | W 9-8 | 79-64 | 3 | 20,400 | Fred Norman | Vern Ruhle | Dave Tomlin | Joaquin Andujar | | 631 | 618 | 13 |
| 1978-09-12 | vs HOU | 144 | W 4-3 | 80-64 | 3 | 20,801 | Paul Moskau | Mark Lemongello | Doug Bair | Joe Sambito | | 635 | 621 | 14 |
| 1978-09-13 | @ SDN | 145 | L 2-6 | 80-65 | 3 | 12,899 | Mike LaCoss | Bob Owchinko | Bob Owchinko | Manny Sarmiento | Rollie Fingers | 637 | 627 | 10 |
| 1978-09-14 | @ SDN | 146 | L 1-8 | 80-66 | 3 | 10,223 | Bill Bonham | Bob Shirley | Bob Shirley | Bill Bonham | John D'Acquisto | 638 | 635 | 3 |
| 1978-09-15 | @ SFN | 147 | W 6-1 | 81-66 | 2 | 22,726 | Tom Seaver | Vida Blue | Tom Seaver | Vida Blue | | 644 | 636 | 8 |
| 1978-09-16 | @ SFN | 148 | L 2-3 | 81-67 | 3 | 29,557 | Tom Hume | John Montefusco | Gary Lavelle | Doug Bair | | 646 | 639 | 7 |
| 1978-09-17 | @ SFN | 149 | W 7-1 | 82-67 | 2 | 31,469 | Paul Moskau | Bob Knepper | Paul Moskau | Bob Knepper | | 653 | 640 | 13 |
| 1978-09-18 | @ LAN | 150 | W 4-0 | 83-67 | 2 | 50,292 | Mike LaCoss | Bob Welch | Mike LaCoss | Bob Welch | | 657 | 640 | 17 |
| 1978-09-19 | @ LAN | 151 | L 0-8 | 83-68 | 2 | 50,450 | Fred Norman | Rick Rhoden | Rick Rhoden | Fred Norman | | 657 | 648 | 9 |
| 1978-09-20 | @ LAN | 152 | W 4-3 | 84-68 | 2 | 51,494 | Tom Seaver | Don Sutton | Tom Seaver | Don Sutton | Doug Bair | 661 | 651 | 10 |
| 1978-09-22 | @ ATL | 153 | W 6-4 | 85-68 | 2 | 7,621 | Paul Moskau | Mickey Mahler | Mario Soto | Craig Skok | | 667 | 655 | 12 |
| 1978-09-23 | @ ATL | 154 | L 1-8 | 85-69 | 2 | 12,784 | Mike LaCoss | Larry McWilliams | Larry McWilliams | Mike LaCoss | | 668 | 663 | 5 |
| 1978-09-24 | @ ATL | 155 | W 2-1 | 86-69 | 2 | 12,298 | Tom Hume | Jim Bouton | Tom Hume | Jim Bouton | | 670 | 664 | 6 |
| 1978-09-26 | vs LAN | 156 | W 6-4 | 87-69 | 2 | 27,189 | Tom Seaver | Rick Rhoden | Tom Seaver | Rick Rhoden | | 676 | 668 | 8 |
| 1978-09-27 | vs LAN | 157 | W 5-3 | 88-69 | 2 | 26,028 | Mario Soto | Don Sutton | Pedro Borbon | Charlie Hough | Doug Bair | 681 | 671 | 10 |
| 1978-09-28 | vs LAN | 158 | W 8-7 | 89-69 | 2 | 25,314 | Mike LaCoss | Doug Rau | Dave Tomlin | Lance Rautzhan | | 689 | 678 | 11 |
| 1978-09-29 | vs ATL | 159 | W 7-2 | 90-69 | 2 | 20,660 | Tom Hume | Jim Bouton | Tom Hume | Jim Bouton | | 696 | 680 | 16 |
| 1978-09-30 | vs ATL | 160 | W 4-0 | 91-69 | 2 | 21,054 | Fred Norman | Phil Niekro | Fred Norman | Phil Niekro | | 700 | 680 | 20 |
| 1978-10-01 | vs ATL | 161 | W 10-8 | 92-69 | 2 | 35,840 | Tom Seaver | Mickey Mahler | Dan Dumoulin | Dave Campbell | | 710 | 688 | 22 |