| 1978-04-07 | @ PIT | 1 | L 0-1 | 0-1 | 4 | 39,028 | Rick Reuschel | John Candelaria | John Candelaria | Rick Reuschel | | 0 | 1 | -1 |
| 1978-04-08 | @ PIT | 2 | L 3-4 | 0-2 | 5 | 9,387 | Ray Burris | Bert Blyleven | Jim Bibby | Bruce Sutter | | 3 | 5 | -2 |
| 1978-04-09 | @ PIT | 3 | W 4-3 | 1-2 | 4 | 11,632 | Woodie Fryman | Jerry Reuss | Donnie Moore | Bruce Kison | Bruce Sutter | 7 | 8 | -1 |
| 1978-04-10 | @ NYN | 4 | L 0-6 | 1-3 | 5 | 3,751 | Dennis Lamp | Craig Swan | Craig Swan | Dennis Lamp | | 7 | 14 | -7 |
| 1978-04-11 | @ NYN | 5 | W 4-2 | 2-3 | 5 | 3,653 | Rick Reuschel | Jerry Koosman | Rick Reuschel | Jerry Koosman | Donnie Moore | 11 | 16 | -5 |
| 1978-04-12 | @ NYN | 6 | W 4-2 | 3-3 | 3 | 6,024 | Ray Burris | Nino Espinosa | Ray Burris | Nino Espinosa | | 15 | 18 | -3 |
| 1978-04-14 | vs PIT | 7 | W 5-4 | 4-3 | 3 | 45,777 | Woodie Fryman | Jerry Reuss | Guillermo Hernandez | Jim Bibby | | 20 | 22 | -2 |
| 1978-04-15 | vs PIT | 8 | L 10-13 | 4-4 | 3 | 20,684 | Dennis Lamp | Jim Rooker | Jim Rooker | Dennis Lamp | | 30 | 35 | -5 |
| 1978-04-16 | vs PIT | 9 | W 5-1 | 5-4 | 2 | 20,921 | Rick Reuschel | Don Robinson | Rick Reuschel | Don Robinson | | 35 | 36 | -1 |
| 1978-04-18 | vs MON | 10 | W 2-1 | 6-4 | 2 | 2,010 | Ray Burris | Steve Rogers | Ray Burris | Steve Rogers | Bruce Sutter | 37 | 37 | 0 |
| 1978-04-19 | vs MON | 11 | L 6-8 | 6-5 | 3 | 2,227 | Woodie Fryman | Rudy May | Darold Knowles | Bruce Sutter | | 43 | 45 | -2 |
| 1978-04-21 | vs NYN | 12 | W 5-0 | 7-5 | 2 | 4,124 | Dennis Lamp | Craig Swan | Dennis Lamp | Craig Swan | | 48 | 45 | 3 |
| 1978-04-22 | vs NYN | 13 | L 2-3 | 7-6 | 3 | 13,785 | Rick Reuschel | Jerry Koosman | Mardie Cornejo | Rick Reuschel | Skip Lockwood | 50 | 48 | 2 |
| 1978-04-23 | vs NYN | 14 | W 3-2 | 8-6 | 2 | 7,692 | Ray Burris | Nino Espinosa | Guillermo Hernandez | Butch Metzger | | 53 | 50 | 3 |
| 1978-04-24 | @ PHI | 15 | L 2-12 | 8-7 | 2 | 20,115 | Woodie Fryman | Randy Lerch | Randy Lerch | Woodie Fryman | | 55 | 62 | -7 |
| 1978-04-25 | @ PHI | 16 | L 0-7 | 8-8 | 4 | 17,227 | Dennis Lamp | Jim Kaat | Jim Kaat | Dennis Lamp | | 55 | 69 | -14 |
| 1978-04-26 | @ PHI | 17 | W 4-2 | 9-8 | 3 | 17,299 | Rick Reuschel | Steve Carlton | Rick Reuschel | Steve Carlton | Bruce Sutter | 59 | 71 | -12 |
| 1978-04-28 | @ ATL | 18 | W 4-3 | 10-8 | 2 | 10,045 | Ray Burris | Jamie Easterly | Bruce Sutter | Dave Campbell | Donnie Moore | 63 | 74 | -11 |
| 1978-04-29 | @ ATL | 19 | L 0-5 | 10-9 | 4 | 7,638 | Woodie Fryman | Phil Niekro | Phil Niekro | Woodie Fryman | | 63 | 79 | -16 |
| 1978-04-30 | @ ATL | 20 | W 7-5 | 11-9 | 3 | 7,269 | Dennis Lamp | Tommy Boggs | Bruce Sutter | Adrian Devine | | 70 | 84 | -14 |
| 1978-05-02 | vs LAN | 21 | W 5-4 | 12-9 | 3 | 6,990 | Rick Reuschel | Tommy John | Bruce Sutter | Mike Garman | | 75 | 88 | -13 |
| 1978-05-03 | vs LAN | 22 | L 5-9 | 12-10 | 3 | 9,252 | Ray Burris | Doug Rau | Doug Rau | Ray Burris | Terry Forster | 80 | 97 | -17 |
| 1978-05-04 | vs LAN | 23 | L 1-4 | 12-11 | 3 | 4,030 | Woodie Fryman | Rick Rhoden | Rick Rhoden | Woodie Fryman | | 81 | 101 | -20 |
| 1978-05-06 | vs SFN | 24 | L 1-2 | 12-12 | 3 | 23,215 | Rick Reuschel | Bob Knepper | Randy Moffitt | Guillermo Hernandez | Gary Lavelle | 82 | 103 | -21 |
| 1978-05-07 | vs SFN | 25 | L 1-2 | 12-13 | 4 | 15,453 | Ray Burris | Vida Blue | Vida Blue | Ray Burris | Gary Lavelle | 83 | 105 | -22 |
| 1978-05-09 | @ SDN | 26 | W 8-5 | 13-13 | 3 | 15,643 | Woodie Fryman | Bob Shirley | Woodie Fryman | Bob Shirley | | 91 | 110 | -19 |
| 1978-05-10 | @ SDN | 27 | L 0-1 | 13-14 | 4 | 17,082 | Dennis Lamp | Randy Jones | Randy Jones | Dennis Lamp | | 91 | 111 | -20 |
| 1978-05-11 | @ SDN | 28 | W 4-3 | 14-14 | 3 | 14,756 | Rick Reuschel | Gaylord Perry | Guillermo Hernandez | Mark Lee | Donnie Moore | 95 | 114 | -19 |
| 1978-05-12 | @ LAN | 29 | W 9-7 | 15-14 | 3 | 52,562 | Ray Burris | Don Sutton | Donnie Moore | Don Sutton | Bruce Sutter | 104 | 121 | -17 |
| 1978-05-13 | @ LAN | 30 | L 2-5 | 15-15 | 3 | 47,970 | Woodie Fryman | Tommy John | Tommy John | Woodie Fryman | Terry Forster | 106 | 126 | -20 |
| 1978-05-14 | @ LAN | 31 | W 10-7 | 16-15 | 3 | 31,698 | Dennis Lamp | Doug Rau | Paul Reuschel | Rick Rhoden | | 116 | 133 | -17 |
| 1978-05-16 | @ SFN | 32 | L 3-4 | 16-16 | 3 | 13,728 | Rick Reuschel | Bob Knepper | Bob Knepper | Rick Reuschel | | 119 | 137 | -18 |
| 1978-05-17 | @ SFN | 33 | L 5-9 | 16-17 | 3 | 12,922 | Ray Burris | Vida Blue | Vida Blue | Ray Burris | | 124 | 146 | -22 |
| 1978-05-19 | vs SLN | 34 | W 6-2 | 17-17 | 3 | 15,389 | Dave Roberts | John Denny | Dave Roberts | John Denny | | 130 | 148 | -18 |
| 1978-05-20 | vs SLN | 35 | W 10-2 | 18-17 | 2 | 27,300 | Dennis Lamp | Pete Falcone | Woodie Fryman | Pete Falcone | Donnie Moore | 140 | 150 | -10 |
| 1978-05-21 | vs SLN | 36 | W 3-2 | 19-17 | 2 | 31,557 | Rick Reuschel | Eric Rasmussen | Rick Reuschel | Mark Littell | Bruce Sutter | 143 | 152 | -9 |
| 1978-05-24 | vs PHI | 37 | W 6-4 | 20-17 | 1 | 17,901 | Ray Burris | Jim Kaat | Bruce Sutter | Gene Garber | | 149 | 156 | -7 |
| 1978-05-25 | vs PHI | 38 | W 5-1 | 21-17 | 1 | 19,788 | Rick Reuschel | Steve Carlton | Rick Reuschel | Steve Carlton | Bruce Sutter | 154 | 157 | -3 |
| 1978-05-26 | @ SLN | 39 | W 6-0 | 22-17 | 1 | 20,068 | Dave Roberts | Pete Falcone | Dave Roberts | Pete Falcone | | 160 | 157 | 3 |
| 1978-05-27 | @ SLN | 40 | W 3-2 | 23-17 | 1 | 33,333 | Dennis Lamp | Bob Forsch | Guillermo Hernandez | Buddy Schultz | | 163 | 159 | 4 |
| 1978-05-28 | @ SLN | 41 | W 2-0 | 24-17 | 1 | 29,704 | Ray Burris | John Denny | Ray Burris | John Denny | | 165 | 159 | 6 |
| 1978-05-29 | @ MON | 42 | L 2-4 | 24-18 | 1 | 22,934 | Woodie Fryman | Ross Grimsley | Ross Grimsley | Donnie Moore | | 167 | 163 | 4 |
| 1978-05-30 | @ MON | 43 | L 4-7 | 24-19 | 1 | 16,106 | Rick Reuschel | Steve Rogers | Steve Rogers | Rick Reuschel | Mike Garman | 171 | 170 | 1 |
| 1978-05-31 | @ MON | 44 | L 1-9 | 24-20 | 1 | 18,647 | Dennis Lamp | Rudy May | Rudy May | Dennis Lamp | | 172 | 179 | -7 |
| 1978-06-02 | vs ATL | 45 | W 2-1 | 25-20 | 1 | 10,177 | Dave Roberts | Preston Hanna | Donnie Moore | Jamie Easterly | | 174 | 180 | -6 |
| 1978-06-03 | vs ATL | 46 | W 8-6 | 26-20 | 1 | 30,362 | Ray Burris | Phil Niekro | Donnie Moore | Jamie Easterly | Bruce Sutter | 182 | 186 | -4 |
| 1978-06-04 | vs ATL | 47 | W 6-4 | 27-20 | 1 | 29,845 | Rick Reuschel | Mickey Mahler | Rick Reuschel | Mickey Mahler | | 188 | 190 | -2 |
| 1978-06-05 | vs HOU | 48 | W 2-1 | 28-20 | 1 | 10,201 | Dennis Lamp | Mark Lemongello | Guillermo Hernandez | Mark Lemongello | | 190 | 191 | -1 |
| 1978-06-06 | vs HOU | 49 | W 9-4 | 29-20 | 1 | 14,107 | Dave Roberts | Joaquin Andujar | Dave Roberts | Joaquin Andujar | | 199 | 195 | 4 |
| 1978-06-07 | vs CIN | 50 | L 6-9 | 29-21 | 1 | 21,093 | Ray Burris | Bill Bonham | Bill Bonham | Ray Burris | Doug Bair | 205 | 204 | 1 |
| 1978-06-08 | vs CIN | 51 | W 10-1 | 30-21 | 1 | 21,137 | Rick Reuschel | Fred Norman | Rick Reuschel | Fred Norman | | 215 | 205 | 10 |
| 1978-06-09 | vs SDN | 52 | W 5-0 | 31-21 | 1 | 15,770 | Dennis Lamp | Bob Owchinko | Dennis Lamp | Bob Owchinko | | 220 | 205 | 15 |
| 1978-06-10 | vs SDN | 53 | L 8-10 | 31-22 | 2 | 31,807 | Dave Roberts | Gaylord Perry | Gaylord Perry | Donnie Moore | Rollie Fingers | 228 | 215 | 13 |
| 1978-06-11 | vs SDN | 54 | W 7-4 | 32-22 | 1 | 36,751 | Ray Burris | Bob Shirley | Ray Burris | Bob Shirley | Bruce Sutter | 235 | 219 | 16 |
| 1978-06-12 | @ CIN | 55 | W 3-2 | 33-22 | 1 | 30,190 | Rick Reuschel | Bill Bonham | Rick Reuschel | Bill Bonham | Ken Holtzman | 238 | 221 | 17 |
| 1978-06-13 | @ CIN | 56 | L 0-1 | 33-23 | 1 | 31,283 | Dennis Lamp | Fred Norman | Fred Norman | Dennis Lamp | Doug Bair | 238 | 222 | 16 |
| 1978-06-14 | @ CIN | 57 | L 1-3 | 33-24 | 1 | 34,658 | Dave Roberts | Manny Sarmiento | Manny Sarmiento | Dave Roberts | Doug Bair | 239 | 225 | 14 |
| 1978-06-16 | @ HOU | 58 | W 7-6 | 34-24 | 1 | 18,948 | Ray Burris | Mark Lemongello | Paul Reuschel | Rick Williams | | 246 | 231 | 15 |
| 1978-06-17 | @ HOU | 59 | L 4-5 | 34-25 | 1 | 28,091 | Dave Geisel | Joaquin Andujar | Joe Niekro | Guillermo Hernandez | | 250 | 236 | 14 |
| 1978-06-18 | @ HOU | 60 | L 1-3 | 34-26 | 1 | 14,770 | Dennis Lamp | Tom Dixon | Tom Dixon | Dennis Lamp | Joe Sambito | 251 | 239 | 12 |
| 1978-06-19 | @ PIT | 61 | W 6-4 | 35-26 | 1 | 8,878 | Dave Roberts | Jim Rooker | Bruce Sutter | Grant Jackson | Guillermo Hernandez | 257 | 243 | 14 |
| 1978-06-20 | @ PIT | 62 | L 1-6 | 35-27 | 1 | 10,912 | Ken Holtzman | Bert Blyleven | Bert Blyleven | Ken Holtzman | | 258 | 249 | 9 |
| 1978-06-21 | @ PIT | 63 | L 1-2 | 35-28 | 1 | 11,064 | Ray Burris | John Candelaria | John Candelaria | Ray Burris | | 259 | 251 | 8 |
| 1978-06-23 | @ PHI | 64 | L 1-6 | 35-30 | 2 | 0 | Dave Roberts | Dick Ruthven | Dick Ruthven | Dave Roberts | | 260 | 257 | 3 |
| 1978-06-23 | @ PHI | 65 | L 1-6 | 35-30 | 2 | 45,234 | Dennis Lamp | Jim Lonborg | Jim Lonborg | Dennis Lamp | | 261 | 263 | -2 |
| 1978-06-24 | @ PHI | 66 | L 2-6 | 35-31 | 2 | 41,605 | Ken Holtzman | Jim Kaat | Jim Kaat | Ken Holtzman | Ron Reed | 263 | 269 | -6 |
| 1978-06-25 | @ PHI | 67 | L 2-4 | 35-32 | 2 | 36,075 | Rick Reuschel | Larry Christenson | Larry Christenson | Rick Reuschel | | 265 | 273 | -8 |
| 1978-06-26 | vs NYN | 68 | W 10-9 | 36-32 | 2 | 12,188 | Ray Burris | Mike Bruhert | Lynn McGlothen | Butch Metzger | Bruce Sutter | 275 | 282 | -7 |
| 1978-06-27 | vs NYN | 69 | L 2-7 | 36-33 | 2 | 16,987 | Dennis Lamp | Pat Zachry | Pat Zachry | Dennis Lamp | | 277 | 289 | -12 |
| 1978-06-28 | vs NYN | 70 | W 9-8 | 37-33 | 2 | 24,278 | Ken Holtzman | Jerry Koosman | Ray Burris | Butch Metzger | | 286 | 297 | -11 |
| 1978-06-29 | vs PHI | 71 | L 3-9 | 37-34 | 2 | 25,669 | Dave Roberts | Jim Kaat | Jim Kaat | Dave Roberts | Tug McGraw | 289 | 306 | -17 |
| 1978-06-30 | vs PHI | 72 | W 2-0 | 38-35 | 2 | 0 | Mike Krukow | Larry Christenson | Mike Krukow | Larry Christenson | | 291 | 306 | -15 |
| 1978-06-30 | vs PHI | 73 | L 5-6 | 38-35 | 2 | 29,525 | Ray Burris | Steve Carlton | Tug McGraw | Bruce Sutter | | 296 | 312 | -16 |
| 1978-07-01 | vs PHI | 74 | L 1-2 | 38-36 | 2 | 26,042 | Dennis Lamp | Randy Lerch | Randy Lerch | Dennis Lamp | Ron Reed | 297 | 314 | -17 |
| 1978-07-02 | vs PHI | 75 | L 5-6 | 38-37 | 2 | 25,934 | Ken Holtzman | Dick Ruthven | Dick Ruthven | Ken Holtzman | Tug McGraw | 302 | 320 | -18 |
| 1978-07-03 | @ SLN | 76 | W 6-2 | 39-37 | 2 | 31,719 | Dave Roberts | Pete Falcone | Dave Roberts | Pete Falcone | Bruce Sutter | 308 | 322 | -14 |
| 1978-07-04 | @ SLN | 77 | W 7-5 | 40-37 | 2 | 21,351 | Ray Burris | Silvio Martinez | Dave Geisel | George Frazier | Bruce Sutter | 315 | 327 | -12 |
| 1978-07-05 | @ SLN | 78 | W 5-1 | 41-37 | 2 | 19,683 | Mike Krukow | Bob Forsch | Mike Krukow | Bob Forsch | Bruce Sutter | 320 | 328 | -8 |
| 1978-07-06 | @ NYN | 79 | L 6-9 | 41-38 | 2 | 10,061 | Dennis Lamp | Nino Espinosa | Nino Espinosa | Lynn McGlothen | Skip Lockwood | 326 | 337 | -11 |
| 1978-07-07 | @ NYN | 80 | W 9-7 | 42-38 | 2 | 13,815 | Dave Roberts | Tom Hausman | Lynn McGlothen | Paul Siebert | Bruce Sutter | 335 | 344 | -9 |
| 1978-07-08 | @ NYN | 81 | L 0-7 | 42-39 | 2 | 23,007 | Ray Burris | Kevin Kobel | Kevin Kobel | Ray Burris | | 335 | 351 | -16 |
| 1978-07-09 | @ NYN | 82 | W 4-1 | 43-39 | 2 | 14,637 | Mike Krukow | Pat Zachry | Mike Krukow | Pat Zachry | Bruce Sutter | 339 | 352 | -13 |
| 1978-07-13 | vs SDN | 83 | L 2-5 | 43-40 | 2 | 21,594 | Rick Reuschel | Gaylord Perry | Gaylord Perry | Rick Reuschel | John D'Acquisto | 341 | 357 | -16 |
| 1978-07-14 | vs SDN | 84 | L 5-9 | 43-41 | 2 | 17,818 | Dave Roberts | Eric Rasmussen | Eric Rasmussen | Dave Roberts | Rollie Fingers | 346 | 366 | -20 |
| 1978-07-15 | vs SDN | 85 | W 3-1 | 44-41 | 2 | 25,511 | Dennis Lamp | Randy Jones | Bruce Sutter | John D'Acquisto | | 349 | 367 | -18 |
| 1978-07-16 | vs LAN | 86 | W 3-2 | 45-42 | 2 | 0 | Mike Krukow | Rick Rhoden | Mike Krukow | Rick Rhoden | Bruce Sutter | 352 | 369 | -17 |
| 1978-07-16 | vs LAN | 87 | L 3-5 | 45-42 | 2 | 41,677 | Ray Burris | Burt Hooton | Burt Hooton | Ray Burris | Lance Rautzhan | 355 | 374 | -19 |
| 1978-07-17 | vs LAN | 88 | L 3-4 | 45-43 | 2 | 26,821 | Rick Reuschel | Tommy John | Terry Forster | Rick Reuschel | Bob Welch | 358 | 378 | -20 |
| 1978-07-18 | vs SFN | 89 | W 7-6 | 46-43 | 2 | 21,143 | Dave Roberts | John Montefusco | Bruce Sutter | Charlie Williams | | 365 | 384 | -19 |
| 1978-07-19 | vs SFN | 90 | L 4-7 | 47-44 | 2 | 0 | Ray Burris | Vida Blue | Vida Blue | Ray Burris | Gary Lavelle | 369 | 391 | -22 |
| 1978-07-19 | vs SFN | 91 | W 7-5 | 47-44 | 2 | 0 | Dennis Lamp | Jim Barr | Donnie Moore | Jim Barr | Bruce Sutter | 376 | 396 | -20 |
| 1978-07-20 | vs SFN | 92 | L 8-9 | 47-45 | 3 | 20,025 | Mike Krukow | Ed Halicki | Gary Lavelle | Donnie Moore | Randy Moffitt | 384 | 405 | -21 |
| 1978-07-21 | @ SDN | 93 | W 5-4 | 48-45 | 3 | 22,982 | Rick Reuschel | Gaylord Perry | Rick Reuschel | Bob Shirley | Bruce Sutter | 389 | 409 | -20 |
| 1978-07-22 | @ SDN | 94 | L 2-4 | 48-46 | 3 | 22,258 | Dave Roberts | Eric Rasmussen | John D'Acquisto | Ray Burris | | 391 | 413 | -22 |
| 1978-07-23 | @ SDN | 95 | W 4-3 | 49-46 | 2 | 21,505 | Dennis Lamp | Randy Jones | Dennis Lamp | Randy Jones | | 395 | 416 | -21 |
| 1978-07-24 | @ LAN | 96 | L 2-3 | 49-47 | 2 | 46,822 | Mike Krukow | Bob Welch | Terry Forster | Donnie Moore | | 397 | 419 | -22 |
| 1978-07-25 | @ LAN | 97 | L 1-3 | 49-48 | 2 | 38,465 | Rick Reuschel | Rick Rhoden | Rick Rhoden | Rick Reuschel | Tommy John | 398 | 422 | -24 |
| 1978-07-26 | @ LAN | 98 | L 2-8 | 49-49 | 2 | 47,329 | Dave Roberts | Burt Hooton | Burt Hooton | Dave Roberts | | 400 | 430 | -30 |
| 1978-07-28 | @ SFN | 99 | W 1-0 | 50-49 | 2 | 25,908 | Dennis Lamp | Bob Knepper | Dennis Lamp | Bob Knepper | | 401 | 430 | -29 |
| 1978-07-29 | @ SFN | 100 | W 5-3 | 51-49 | 2 | 19,809 | Mike Krukow | John Montefusco | Guillermo Hernandez | Gary Lavelle | Ray Burris | 406 | 433 | -27 |
| 1978-07-30 | @ SFN | 101 | L 2-4 | 51-51 | 2 | 0 | Rick Reuschel | Jim Barr | Jim Barr | Rick Reuschel | Randy Moffitt | 408 | 437 | -29 |
| 1978-07-30 | @ SFN | 102 | L 0-1 | 51-51 | 2 | 37,779 | Dave Roberts | Vida Blue | Vida Blue | Dave Roberts | | 408 | 438 | -30 |
| 1978-08-01 | vs SLN | 103 | W 4-2 | 52-51 | 2 | 22,242 | Dennis Lamp | Silvio Martinez | Dennis Lamp | Silvio Martinez | Bruce Sutter | 412 | 440 | -28 |
| 1978-08-02 | vs SLN | 104 | W 3-2 | 53-51 | 2 | 14,610 | Mike Krukow | Aurelio Lopez | Mike Krukow | Aurelio Lopez | Bruce Sutter | 415 | 442 | -27 |
| 1978-08-03 | vs SLN | 105 | W 3-2 | 54-51 | 2 | 21,596 | Ken Holtzman | Pete Vuckovich | Donnie Moore | Pete Vuckovich | | 418 | 444 | -26 |
| 1978-08-04 | vs MON | 106 | W 6-4 | 55-51 | 2 | 20,621 | Rick Reuschel | Woodie Fryman | Rick Reuschel | Mike Garman | Bruce Sutter | 424 | 448 | -24 |
| 1978-08-05 | vs MON | 107 | L 4-7 | 55-52 | 2 | 31,219 | Dave Roberts | Ross Grimsley | Ross Grimsley | Dave Roberts | Stan Bahnsen | 428 | 455 | -27 |
| 1978-08-06 | vs MON | 108 | L 1-2 | 56-53 | 2 | 0 | Dennis Lamp | Steve Rogers | Steve Rogers | Dennis Lamp | Darold Knowles | 429 | 457 | -28 |
| 1978-08-06 | vs MON | 109 | W 4-3 | 56-53 | 2 | 39,234 | Ray Burris | Scott Sanderson | Lynn McGlothen | Mike Garman | Bruce Sutter | 433 | 460 | -27 |
| 1978-08-07 | vs PIT | 110 | W 5-4 | 57-53 | 2 | 18,615 | Mike Krukow | Jerry Reuss | Donnie Moore | Jerry Reuss | Bruce Sutter | 438 | 464 | -26 |
| 1978-08-08 | vs PIT | 111 | L 5-9 | 57-54 | 2 | 26,037 | Rick Reuschel | Don Robinson | Don Robinson | Rick Reuschel | | 443 | 473 | -30 |
| 1978-08-09 | vs PIT | 112 | W 5-4 | 58-54 | 2 | 23,310 | Dave Roberts | Jim Rooker | Dave Roberts | Ed Whitson | | 448 | 477 | -29 |
| 1978-08-11 | @ MON | 113 | L 0-1 | 58-55 | 2 | 17,956 | Dennis Lamp | Ross Grimsley | Ross Grimsley | Dennis Lamp | | 448 | 478 | -30 |
| 1978-08-12 | @ MON | 114 | L 3-4 | 58-56 | 2 | 26,767 | Mike Krukow | Steve Rogers | Stan Bahnsen | Donnie Moore | | 451 | 482 | -31 |
| 1978-08-13 | @ MON | 115 | W 2-1 | 59-56 | 2 | 24,394 | Rick Reuschel | Scott Sanderson | Rick Reuschel | Scott Sanderson | | 453 | 483 | -30 |
| 1978-08-14 | vs ATL | 116 | W 13-7 | 60-56 | 2 | 27,130 | Dave Roberts | Mickey Mahler | Lynn McGlothen | Mickey Mahler | | 466 | 490 | -24 |
| 1978-08-15 | vs ATL | 117 | W 12-8 | 61-56 | 2 | 18,497 | Dennis Lamp | Larry McWilliams | Donnie Moore | Rick Camp | | 478 | 498 | -20 |
| 1978-08-16 | vs ATL | 118 | L 0-9 | 61-57 | 2 | 19,828 | Mike Krukow | Phil Niekro | Phil Niekro | Mike Krukow | | 478 | 507 | -29 |
| 1978-08-17 | vs CIN | 119 | W 2-0 | 62-57 | 2 | 36,814 | Rick Reuschel | Tom Seaver | Rick Reuschel | Tom Seaver | | 480 | 507 | -27 |
| 1978-08-18 | vs CIN | 120 | L 3-8 | 62-58 | 2 | 33,416 | Dave Roberts | Fred Norman | Pedro Borbon | Dave Roberts | Tom Hume | 483 | 515 | -32 |
| 1978-08-19 | vs CIN | 121 | L 7-9 | 62-59 | 2 | 38,740 | Dennis Lamp | Paul Moskau | Tom Hume | Bruce Sutter | | 490 | 524 | -34 |
| 1978-08-20 | vs CIN | 122 | W 2-1 | 63-59 | 2 | 39,242 | Ray Burris | Mike LaCoss | Guillermo Hernandez | Mike LaCoss | | 492 | 525 | -33 |
| 1978-08-21 | @ HOU | 123 | L 3-8 | 63-60 | 2 | 9,906 | Rick Reuschel | J.R. Richard | J.R. Richard | Rick Reuschel | | 495 | 533 | -38 |
| 1978-08-22 | @ HOU | 124 | L 1-2 | 63-61 | 2 | 9,721 | Mike Krukow | Mark Lemongello | Mark Lemongello | Mike Krukow | | 496 | 535 | -39 |
| 1978-08-23 | @ HOU | 125 | L 0-3 | 63-62 | 2 | 9,217 | Dennis Lamp | Ken Forsch | Ken Forsch | Dennis Lamp | Joe Sambito | 496 | 538 | -42 |
| 1978-08-25 | @ CIN | 126 | W 5-2 | 64-62 | 2 | 39,070 | Rick Reuschel | Mike LaCoss | Rick Reuschel | Mike LaCoss | | 501 | 540 | -39 |
| 1978-08-26 | @ CIN | 127 | W 8-6 | 65-62 | 2 | 47,299 | Ray Burris | Bill Bonham | Dave Roberts | Doug Bair | Bruce Sutter | 509 | 546 | -37 |
| 1978-08-27 | @ CIN | 128 | W 7-1 | 66-62 | 2 | 40,014 | Mike Krukow | Tom Seaver | Mike Krukow | Tom Seaver | | 516 | 547 | -31 |
| 1978-08-28 | @ ATL | 129 | L 3-4 | 66-63 | 2 | 4,007 | Dennis Lamp | Phil Niekro | Phil Niekro | Donnie Moore | Gene Garber | 519 | 551 | -32 |
| 1978-08-29 | @ ATL | 130 | L 3-4 | 66-64 | 2 | 3,244 | Rick Reuschel | Eddie Solomon | Eddie Solomon | Lynn McGlothen | Gene Garber | 522 | 555 | -33 |
| 1978-08-30 | @ ATL | 131 | L 2-6 | 66-65 | 3 | 3,305 | Ray Burris | Larry McWilliams | Larry McWilliams | Ray Burris | | 524 | 561 | -37 |
| 1978-09-01 | vs HOU | 132 | W 14-11 | 67-65 | 3 | 16,117 | Mike Krukow | J.R. Richard | Guillermo Hernandez | Joe Sambito | Bruce Sutter | 538 | 572 | -34 |
| 1978-09-02 | vs HOU | 133 | L 5-8 | 67-66 | 3 | 24,064 | Rick Reuschel | Mark Lemongello | Joaquin Andujar | Bruce Sutter | Joe Sambito | 543 | 580 | -37 |
| 1978-09-03 | vs HOU | 134 | W 3-2 | 69-66 | 3 | 0 | Dennis Lamp | Ken Forsch | Dennis Lamp | Ken Forsch | Guillermo Hernandez | 546 | 582 | -36 |
| 1978-09-03 | vs HOU | 135 | W 4-2 | 69-66 | 3 | 29,528 | Manny Seoane | Vern Ruhle | Donnie Moore | Vern Ruhle | Guillermo Hernandez | 550 | 584 | -34 |
| 1978-09-04 | vs MON | 136 | L 3-5 | 69-68 | 3 | 0 | Ray Burris | Dan Schatzeder | Dan Schatzeder | Ray Burris | Darold Knowles | 553 | 589 | -36 |
| 1978-09-04 | vs MON | 137 | L 5-6 | 69-68 | 3 | 29,833 | Mike Krukow | Rudy May | Mike Garman | Bruce Sutter | Bill Atkinson | 558 | 595 | -37 |
| 1978-09-05 | vs MON | 138 | L 8-10 | 69-69 | 3 | 7,579 | Donnie Moore | Woodie Fryman | Wayne Twitchell | Bruce Sutter | Mike Garman | 566 | 605 | -39 |
| 1978-09-06 | vs PHI | 139 | L 1-8 | 69-70 | 3 | 14,269 | Rick Reuschel | Steve Carlton | Steve Carlton | Rick Reuschel | | 567 | 613 | -46 |
| 1978-09-07 | vs PHI | 140 | L 3-5 | 69-71 | 3 | 11,427 | Dennis Lamp | Larry Christenson | Warren Brusstar | Donnie Moore | Ron Reed | 570 | 618 | -48 |
| 1978-09-08 | @ MON | 141 | W 4-2 | 70-71 | 3 | 11,621 | Ray Burris | Scott Sanderson | Bruce Sutter | Mike Garman | | 574 | 620 | -46 |
| 1978-09-09 | @ MON | 142 | W 6-3 | 71-71 | 3 | 15,217 | Mike Krukow | Dan Schatzeder | Mike Krukow | Dan Schatzeder | Bruce Sutter | 580 | 623 | -43 |
| 1978-09-10 | @ MON | 143 | W 6-3 | 72-71 | 3 | 14,772 | Rick Reuschel | Woodie Fryman | Rick Reuschel | Woodie Fryman | | 586 | 626 | -40 |
| 1978-09-11 | @ NYN | 144 | W 9-4 | 73-71 | 3 | 4,096 | Dennis Lamp | Mike Bruhert | Dennis Lamp | Mike Bruhert | | 595 | 630 | -35 |
| 1978-09-13 | @ PHI | 145 | L 2-6 | 73-72 | 3 | 30,114 | Ray Burris | Dick Ruthven | Dick Ruthven | Ray Burris | | 597 | 636 | -39 |
| 1978-09-14 | @ PHI | 146 | L 5-11 | 73-73 | 3 | 20,037 | Rick Reuschel | Randy Lerch | Warren Brusstar | Rick Reuschel | Ron Reed | 602 | 647 | -45 |
| 1978-09-15 | vs SLN | 147 | L 2-6 | 73-74 | 3 | 5,097 | Mike Krukow | Rob Dressler | Mark Littell | Bruce Sutter | | 604 | 653 | -49 |
| 1978-09-16 | vs SLN | 148 | L 1-4 | 73-75 | 3 | 18,738 | Dennis Lamp | John Denny | John Denny | Dennis Lamp | Mark Littell | 605 | 657 | -52 |
| 1978-09-17 | vs SLN | 149 | W 4-2 | 74-75 | 3 | 18,340 | Ray Burris | Pete Vuckovich | Ray Burris | Pete Vuckovich | | 609 | 659 | -50 |
| 1978-09-19 | vs PIT | 150 | L 11-12 | 74-76 | 3 | 6,137 | Rick Reuschel | John Candelaria | Odell Jones | Bruce Sutter | | 620 | 671 | -51 |
| 1978-09-20 | vs PIT | 151 | W 5-1 | 75-76 | 3 | 5,269 | Mike Krukow | Jim Rooker | Mike Krukow | Jim Rooker | | 625 | 672 | -47 |
| 1978-09-21 | vs PIT | 152 | L 2-3 | 75-77 | 3 | 2,423 | Dennis Lamp | Don Robinson | Ed Whitson | Bruce Sutter | Jim Bibby | 627 | 675 | -48 |
| 1978-09-22 | @ SLN | 153 | W 5-3 | 76-77 | 3 | 15,062 | Ray Burris | Bob Forsch | Ray Burris | Aurelio Lopez | Dave Roberts | 632 | 678 | -46 |
| 1978-09-23 | @ SLN | 154 | L 1-5 | 76-78 | 3 | 16,790 | Rick Reuschel | John Denny | John Denny | Rick Reuschel | | 633 | 683 | -50 |
| 1978-09-24 | @ SLN | 155 | W 5-4 | 77-78 | 3 | 17,033 | Ken Holtzman | Pete Vuckovich | Lynn McGlothen | Tom Bruno | Bruce Sutter | 638 | 687 | -49 |
| 1978-09-25 | @ PIT | 156 | L 4-7 | 77-79 | 3 | 5,937 | Mike Krukow | John Candelaria | John Candelaria | Mike Krukow | | 642 | 694 | -52 |
| 1978-09-26 | @ PIT | 157 | L 2-5 | 77-80 | 3 | 6,515 | Dennis Lamp | Don Robinson | Don Robinson | Dennis Lamp | | 644 | 699 | -55 |
| 1978-09-27 | @ PIT | 158 | L 3-8 | 77-81 | 3 | 7,467 | Ray Burris | Jerry Reuss | Jerry Reuss | Ray Burris | | 647 | 707 | -60 |
| 1978-09-29 | vs NYN | 159 | L 2-3 | 78-82 | 3 | 0 | Rick Reuschel | Nino Espinosa | Nino Espinosa | Rick Reuschel | Jerry Koosman | 649 | 710 | -61 |
| 1978-09-29 | vs NYN | 160 | W 5-4 | 78-82 | 3 | 3,333 | Mike Krukow | Mike Bruhert | Mike Krukow | Mike Bruhert | Bruce Sutter | 654 | 714 | -60 |
| 1978-09-30 | vs NYN | 161 | W 7-5 | 79-82 | 3 | 16,504 | Dennis Lamp | Juan Berenguer | Manny Seoane | Dwight Bernard | Ken Holtzman | 661 | 719 | -58 |
| 1978-10-01 | vs NYN | 162 | L 3-5 | 79-83 | 3 | 11,617 | Lynn McGlothen | Kevin Kobel | Kevin Kobel | Lynn McGlothen | Dale Murray | 664 | 724 | -60 |