| 1978-04-07 | @ MIL | 1 | L 3-11 | 0-1 | 3 | 47,824 | Mike Flanagan | Jerry Augustine | Jerry Augustine | Mike Flanagan | | 3 | 11 | -8 |
| 1978-04-08 | @ MIL | 2 | L 3-16 | 0-2 | 5 | 6,470 | Dennis Martinez | Moose Haas | Moose Haas | Dennis Martinez | | 6 | 27 | -21 |
| 1978-04-09 | @ MIL | 3 | L 5-13 | 0-3 | 7 | 18,514 | Scott McGregor | Lary Sorensen | Lary Sorensen | Scott McGregor | | 11 | 40 | -29 |
| 1978-04-10 | @ KCA | 4 | L 2-4 | 0-4 | 7 | 38,194 | Nelson Briles | Paul Splittorff | Paul Splittorff | Nelson Briles | Al Hrabosky | 13 | 44 | -31 |
| 1978-04-12 | @ KCA | 5 | L 2-5 | 0-5 | 7 | 17,449 | Mike Flanagan | Dennis Leonard | Dennis Leonard | Mike Flanagan | Steve Mingori | 15 | 49 | -34 |
| 1978-04-14 | vs MIL | 6 | W 6-5 | 1-5 | 7 | 36,086 | Dennis Martinez | Lary Sorensen | Dennis Martinez | Lary Sorensen | Don Stanhouse | 21 | 54 | -33 |
| 1978-04-15 | vs MIL | 7 | W 7-0 | 2-5 | 6 | 7,527 | Jim Palmer | Jerry Augustine | Jim Palmer | Jerry Augustine | | 28 | 54 | -26 |
| 1978-04-16 | vs MIL | 8 | W 7-5 | 3-6 | 5 | 0 | Nelson Briles | Moose Haas | Nelson Briles | Moose Haas | Don Stanhouse | 35 | 59 | -24 |
| 1978-04-16 | vs MIL | 9 | L 2-9 | 3-6 | 5 | 14,995 | Scott McGregor | Andy Replogle | Andy Replogle | Scott McGregor | Eduardo Rodriguez | 37 | 68 | -31 |
| 1978-04-17 | @ NYA | 10 | W 6-1 | 4-6 | 5 | 15,674 | Mike Flanagan | Catfish Hunter | Mike Flanagan | Catfish Hunter | | 43 | 69 | -26 |
| 1978-04-18 | @ NYA | 11 | L 3-4 | 4-7 | 6 | 15,628 | Dennis Martinez | Ron Guidry | Sparky Lyle | Tippy Martinez | | 46 | 73 | -27 |
| 1978-04-21 | vs KCA | 12 | W 2-1 | 5-7 | 4 | 6,203 | Jim Palmer | Dennis Leonard | Jim Palmer | Dennis Leonard | Don Stanhouse | 48 | 74 | -26 |
| 1978-04-22 | vs KCA | 13 | L 3-5 | 5-8 | 6 | 7,277 | Mike Flanagan | Paul Splittorff | Paul Splittorff | Mike Flanagan | Al Hrabosky | 51 | 79 | -28 |
| 1978-04-23 | vs KCA | 14 | L 5-6 | 5-9 | 6 | 13,833 | Dennis Martinez | Steve Busby | Larry Gura | Tim Stoddard | Marty Pattin | 56 | 85 | -29 |
| 1978-04-24 | vs NYA | 15 | L 2-8 | 5-10 | 6 | 18,053 | Scott McGregor | Ron Guidry | Ron Guidry | Scott McGregor | | 58 | 93 | -35 |
| 1978-04-25 | vs NYA | 16 | L 3-4 | 5-11 | 6 | 14,159 | Jim Palmer | Jim Beattie | Jim Beattie | Jim Palmer | Sparky Lyle | 61 | 97 | -36 |
| 1978-04-28 | @ CHA | 17 | W 6-4 | 6-11 | 7 | 25,395 | Dennis Martinez | Steve Stone | Dennis Martinez | Pablo Torrealba | Don Stanhouse | 67 | 101 | -34 |
| 1978-04-29 | @ CHA | 18 | W 5-2 | 7-11 | 6 | 22,240 | Jim Palmer | Ken Kravec | Jim Palmer | Ken Kravec | Don Stanhouse | 72 | 103 | -31 |
| 1978-04-30 | @ CHA | 19 | W 8-7 | 8-11 | 5 | 17,786 | Mike Flanagan | Francisco Barrios | Scott McGregor | Pablo Torrealba | | 80 | 110 | -30 |
| 1978-05-01 | @ BOS | 20 | L 6-9 | 8-12 | 6 | 18,710 | Nelson Briles | Mike Torrez | Mike Torrez | Nelson Briles | Bob Stanley | 86 | 119 | -33 |
| 1978-05-02 | @ BOS | 21 | W 3-1 | 9-12 | 5 | 19,930 | Dennis Martinez | Allen Ripley | Dennis Martinez | Allen Ripley | | 89 | 120 | -31 |
| 1978-05-03 | vs TEX | 22 | L 1-2 | 9-13 | 6 | 6,118 | Jim Palmer | Doyle Alexander | Doyle Alexander | Don Stanhouse | | 90 | 122 | -32 |
| 1978-05-05 | vs MIN | 23 | W 2-1 | 10-13 | 6 | 3,897 | Mike Flanagan | Geoff Zahn | Mike Flanagan | Geoff Zahn | | 92 | 123 | -31 |
| 1978-05-06 | vs MIN | 24 | L 7-8 | 10-14 | 6 | 26,870 | Dennis Martinez | Roger Erickson | Greg Thayer | Don Stanhouse | Tom Johnson | 99 | 131 | -32 |
| 1978-05-07 | vs MIN | 25 | L 9-15 | 10-15 | 6 | 8,923 | Jim Palmer | Gary Serum | Mac Scarce | Jim Palmer | | 108 | 146 | -38 |
| 1978-05-10 | vs BOS | 26 | W 3-2 | 11-15 | 6 | 10,023 | Mike Flanagan | Allen Ripley | Mike Flanagan | Tom Burgmeier | | 111 | 148 | -37 |
| 1978-05-11 | vs BOS | 27 | L 4-5 | 11-16 | 6 | 14,950 | Dennis Martinez | Bill Lee | Bill Lee | Dennis Martinez | Dick Drago | 115 | 153 | -38 |
| 1978-05-12 | @ TEX | 28 | L 3-9 | 11-17 | 6 | 30,803 | Jim Palmer | Jon Matlack | Jon Matlack | Jim Palmer | | 118 | 162 | -44 |
| 1978-05-13 | @ TEX | 29 | W 5-1 | 12-17 | 6 | 32,700 | Scott McGregor | Jim Umbarger | Scott McGregor | Jim Umbarger | | 123 | 163 | -40 |
| 1978-05-14 | @ TEX | 30 | W 3-2 | 13-17 | 6 | 16,440 | Mike Flanagan | Dock Ellis | John Flinn | Dock Ellis | Don Stanhouse | 126 | 165 | -39 |
| 1978-05-15 | @ MIN | 31 | L 6-9 | 13-18 | 6 | 3,847 | Dennis Martinez | Roger Erickson | Mike Marshall | John Flinn | | 132 | 174 | -42 |
| 1978-05-16 | @ MIN | 32 | L 1-8 | 13-19 | 6 | 4,893 | Jim Palmer | Dave Goltz | Dave Goltz | Jim Palmer | Tom Johnson | 133 | 182 | -49 |
| 1978-05-18 | vs TOR | 33 | W 5-3 | 14-19 | 6 | 4,255 | Mike Flanagan | Jim Clancy | Mike Flanagan | Jim Clancy | | 138 | 185 | -47 |
| 1978-05-19 | @ CLE | 34 | L 5-7 | 14-20 | 6 | 15,565 | Dennis Martinez | Mike Paxton | Jim Kern | Don Stanhouse | | 143 | 192 | -49 |
| 1978-05-20 | @ CLE | 35 | W 2-1 | 15-20 | 6 | 11,426 | Jim Palmer | Rick Wise | Jim Palmer | Rick Wise | Don Stanhouse | 145 | 193 | -48 |
| 1978-05-21 | @ CLE | 36 | W 3-0 | 16-21 | 6 | 0 | Scott McGregor | Rick Waits | Scott McGregor | Rick Waits | | 148 | 193 | -45 |
| 1978-05-21 | @ CLE | 37 | L 2-3 | 16-21 | 6 | 23,206 | Nelson Briles | David Clyde | David Clyde | Nelson Briles | Dennis Kinney | 150 | 196 | -46 |
| 1978-05-23 | vs DET | 38 | W 2-0 | 17-21 | 6 | 4,536 | Mike Flanagan | Jack Billingham | Mike Flanagan | Jack Billingham | | 152 | 196 | -44 |
| 1978-05-24 | vs DET | 39 | L 2-3 | 18-22 | 6 | 0 | Dennis Martinez | Jim Slaton | John Hiller | Dennis Martinez | | 154 | 199 | -45 |
| 1978-05-24 | vs DET | 40 | W 1-0 | 18-22 | 6 | 8,196 | Jim Palmer | Bob Sykes | Jim Palmer | Bob Sykes | | 155 | 199 | -44 |
| 1978-05-25 | vs DET | 41 | W 2-1 | 19-22 | 5 | 5,109 | Scott McGregor | Steve Baker | Scott McGregor | John Hiller | | 157 | 200 | -43 |
| 1978-05-26 | vs CLE | 42 | W 4-3 | 20-22 | 5 | 29,215 | Nelson Briles | Rick Wise | Tippy Martinez | Rick Wise | | 161 | 203 | -42 |
| 1978-05-27 | vs CLE | 43 | L 2-6 | 20-23 | 5 | 8,920 | Mike Flanagan | David Clyde | David Clyde | Mike Flanagan | | 163 | 209 | -46 |
| 1978-05-28 | vs CLE | 44 | L 3-4 | 21-24 | 5 | 0 | Dennis Martinez | Don Hood | Sid Monge | Don Stanhouse | | 166 | 213 | -47 |
| 1978-05-28 | vs CLE | 45 | W 3-0 | 21-24 | 5 | 18,276 | Jim Palmer | Mike Paxton | Jim Palmer | Mike Paxton | | 169 | 213 | -44 |
| 1978-05-29 | @ DET | 46 | W 6-3 | 22-24 | 5 | 20,534 | Scott McGregor | Bob Sykes | Scott McGregor | Bob Sykes | | 175 | 216 | -41 |
| 1978-05-30 | @ DET | 47 | L 2-5 | 22-25 | 5 | 10,530 | Nelson Briles | Steve Baker | Steve Baker | Nelson Briles | John Hiller | 177 | 221 | -44 |
| 1978-05-31 | @ NYA | 48 | W 3-2 | 23-25 | 5 | 21,404 | Mike Flanagan | Ed Figueroa | Mike Flanagan | Ed Figueroa | | 180 | 223 | -43 |
| 1978-06-01 | @ NYA | 49 | W 1-0 | 24-25 | 5 | 19,943 | Jim Palmer | Jim Beattie | Jim Palmer | Jim Beattie | | 181 | 223 | -42 |
| 1978-06-02 | @ SEA | 50 | W 10-9 | 25-25 | 4 | 4,936 | Dennis Martinez | Jim Colborn | Dennis Martinez | Jim Colborn | Don Stanhouse | 191 | 232 | -41 |
| 1978-06-03 | @ SEA | 51 | W 2-1 | 26-25 | 4 | 15,002 | Scott McGregor | Paul Mitchell | Scott McGregor | Paul Mitchell | Tippy Martinez | 193 | 233 | -40 |
| 1978-06-04 | @ SEA | 52 | W 4-1 | 27-25 | 4 | 6,429 | Mike Flanagan | Dick Pole | Mike Flanagan | Dick Pole | | 197 | 234 | -37 |
| 1978-06-05 | @ CAL | 53 | W 6-2 | 28-25 | 4 | 13,231 | Jim Palmer | Don Aase | Don Stanhouse | Dave LaRoche | | 203 | 236 | -33 |
| 1978-06-06 | @ CAL | 54 | W 8-6 | 29-25 | 4 | 15,864 | Dennis Martinez | Nolan Ryan | Dennis Martinez | Nolan Ryan | Don Stanhouse | 211 | 242 | -31 |
| 1978-06-09 | @ OAK | 55 | W 5-3 | 30-25 | 4 | 3,323 | Mike Flanagan | Pete Broberg | Mike Flanagan | Pete Broberg | | 216 | 245 | -29 |
| 1978-06-10 | @ OAK | 56 | W 1-0 | 31-25 | 4 | 11,422 | Jim Palmer | Steve Renko | Jim Palmer | Steve Renko | | 217 | 245 | -28 |
| 1978-06-11 | @ OAK | 57 | W 3-0 | 32-25 | 4 | 17,157 | Scott McGregor | Mike Morgan | Scott McGregor | Mike Morgan | | 220 | 245 | -25 |
| 1978-06-12 | vs SEA | 58 | W 5-4 | 33-25 | 3 | 13,212 | Dennis Martinez | Jim Colborn | Tippy Martinez | Jim Colborn | Don Stanhouse | 225 | 249 | -24 |
| 1978-06-13 | vs SEA | 59 | W 3-2 | 34-25 | 3 | 7,729 | Mike Flanagan | Glenn Abbott | Mike Flanagan | Enrique Romo | | 228 | 251 | -23 |
| 1978-06-14 | vs CAL | 60 | W 5-2 | 35-25 | 3 | 21,815 | Jim Palmer | Ken Brett | Jim Palmer | Ken Brett | | 233 | 253 | -20 |
| 1978-06-15 | vs CAL | 61 | L 1-5 | 35-26 | 3 | 15,004 | Scott McGregor | Frank Tanana | Frank Tanana | Scott McGregor | | 234 | 258 | -24 |
| 1978-06-16 | vs OAK | 62 | W 6-0 | 36-26 | 3 | 31,944 | Dennis Martinez | Rick Langford | Dennis Martinez | Rick Langford | | 240 | 258 | -18 |
| 1978-06-17 | vs OAK | 63 | W 5-4 | 37-26 | 3 | 24,619 | Mike Flanagan | Mike Morgan | Mike Flanagan | Mike Morgan | Don Stanhouse | 245 | 262 | -17 |
| 1978-06-18 | vs OAK | 64 | W 2-1 | 38-26 | 2 | 17,143 | Jim Palmer | John Henry Johnson | Jim Palmer | John Henry Johnson | Tippy Martinez | 247 | 263 | -16 |
| 1978-06-20 | @ MIL | 65 | W 8-5 | 39-26 | 2 | 22,640 | Scott McGregor | Bill Travers | Scott McGregor | Bill Travers | | 255 | 268 | -13 |
| 1978-06-21 | @ MIL | 66 | L 3-5 | 39-27 | 2 | 21,732 | Dennis Martinez | Lary Sorensen | Lary Sorensen | Dennis Martinez | Bill Castro | 258 | 273 | -15 |
| 1978-06-22 | @ MIL | 67 | W 10-3 | 40-27 | 2 | 26,586 | Mike Flanagan | Moose Haas | Mike Flanagan | Moose Haas | | 268 | 276 | -8 |
| 1978-06-23 | @ BOS | 68 | L 2-5 | 40-28 | 2 | 34,582 | Jim Palmer | Bill Lee | Bill Lee | Jim Palmer | | 270 | 281 | -11 |
| 1978-06-24 | @ BOS | 69 | L 3-8 | 40-29 | 2 | 32,213 | Scott McGregor | Luis Tiant | Luis Tiant | Scott McGregor | | 273 | 289 | -16 |
| 1978-06-25 | @ BOS | 70 | L 1-4 | 40-30 | 3 | 33,526 | Dennis Martinez | Mike Torrez | Mike Torrez | Dennis Martinez | | 274 | 293 | -19 |
| 1978-06-26 | @ TOR | 71 | L 10-24 | 40-31 | 3 | 16,184 | Mike Flanagan | Tom Underwood | Tom Underwood | Mike Flanagan | | 284 | 317 | -33 |
| 1978-06-27 | @ TOR | 72 | L 2-6 | 40-33 | 4 | 0 | Jim Palmer | Dave Lemanczyk | Dave Lemanczyk | Jim Palmer | Victor Cruz | 286 | 323 | -37 |
| 1978-06-27 | @ TOR | 73 | L 8-9 | 40-33 | 4 | 38,563 | Nelson Briles | Jesse Jefferson | Victor Cruz | Don Stanhouse | | 294 | 332 | -38 |
| 1978-06-28 | @ TOR | 74 | L 2-3 | 40-34 | 4 | 28,392 | Scott McGregor | Jim Clancy | Jim Clancy | Scott McGregor | Tom Murphy | 296 | 335 | -39 |
| 1978-06-29 | vs BOS | 75 | L 3-4 | 40-35 | 4 | 28,899 | Dennis Martinez | Bill Lee | Allen Ripley | Dennis Martinez | | 299 | 339 | -40 |
| 1978-06-30 | vs BOS | 76 | W 3-2 | 41-35 | 4 | 33,034 | Mike Flanagan | Luis Tiant | Don Stanhouse | Luis Tiant | | 302 | 341 | -39 |
| 1978-07-01 | vs BOS | 77 | W 3-2 | 42-35 | 4 | 38,542 | Jim Palmer | Mike Torrez | Nelson Briles | Mike Torrez | | 305 | 343 | -38 |
| 1978-07-03 | @ CLE | 78 | L 0-9 | 42-36 | 4 | 9,302 | Scott McGregor | Mike Paxton | Mike Paxton | Scott McGregor | | 305 | 352 | -47 |
| 1978-07-04 | @ CLE | 79 | W 6-4 | 43-36 | 4 | 36,300 | Dennis Martinez | David Clyde | Dennis Martinez | David Clyde | Don Stanhouse | 311 | 356 | -45 |
| 1978-07-05 | vs TOR | 80 | W 3-1 | 45-36 | 4 | 0 | Mike Flanagan | Jerry Garvin | Mike Flanagan | Jerry Garvin | | 314 | 357 | -43 |
| 1978-07-05 | vs TOR | 81 | W 8-6 | 45-36 | 4 | 9,886 | Nelson Briles | Tom Underwood | Joe Kerrigan | Tom Murphy | | 322 | 363 | -41 |
| 1978-07-06 | vs TOR | 82 | L 0-2 | 45-37 | 4 | 14,926 | Jim Palmer | Dave Lemanczyk | Dave Lemanczyk | Jim Palmer | Mike Willis | 322 | 365 | -43 |
| 1978-07-07 | @ KCA | 83 | L 1-3 | 45-38 | 4 | 23,314 | Scott McGregor | Paul Splittorff | Paul Splittorff | Scott McGregor | | 323 | 368 | -45 |
| 1978-07-08 | @ KCA | 84 | L 3-11 | 45-39 | 4 | 34,587 | Dennis Martinez | Rich Gale | Rich Gale | Dennis Martinez | | 326 | 379 | -53 |
| 1978-07-09 | @ KCA | 85 | L 4-10 | 45-40 | 4 | 24,662 | Mike Flanagan | Dennis Leonard | Dennis Leonard | Mike Flanagan | | 330 | 389 | -59 |
| 1978-07-13 | vs MIN | 86 | W 8-6 | 46-40 | 4 | 8,119 | Mike Flanagan | Dave Goltz | Mike Flanagan | Dave Goltz | Tippy Martinez | 338 | 395 | -57 |
| 1978-07-14 | vs MIN | 87 | W 5-1 | 47-40 | 4 | 24,195 | Scott McGregor | Geoff Zahn | Scott McGregor | Geoff Zahn | | 343 | 396 | -53 |
| 1978-07-15 | vs TEX | 88 | W 8-7 | 48-41 | 4 | 0 | Dennis Martinez | Doyle Alexander | Tippy Martinez | Len Barker | | 351 | 403 | -52 |
| 1978-07-15 | vs TEX | 89 | L 1-11 | 48-41 | 4 | 22,353 | Jim Palmer | Doc Medich | Doc Medich | Jim Palmer | | 352 | 414 | -62 |
| 1978-07-16 | vs TEX | 90 | W 2-1 | 49-41 | 3 | 11,839 | Joe Kerrigan | Jon Matlack | Don Stanhouse | Reggie Cleveland | | 354 | 415 | -61 |
| 1978-07-17 | vs TEX | 91 | L 0-2 | 49-42 | 3 | 11,676 | Mike Flanagan | Steve Comer | Reggie Cleveland | Mike Flanagan | | 354 | 417 | -63 |
| 1978-07-18 | vs TEX | 92 | W 5-1 | 50-42 | 3 | 10,832 | Scott McGregor | Dock Ellis | Scott McGregor | Dock Ellis | | 359 | 418 | -59 |
| 1978-07-19 | @ CHA | 93 | W 10-3 | 51-42 | 3 | 18,682 | Jim Palmer | Ken Kravec | Jim Palmer | Ken Kravec | | 369 | 421 | -52 |
| 1978-07-21 | @ MIN | 94 | W 5-4 | 52-42 | 3 | 14,702 | Mike Flanagan | Roger Erickson | Don Stanhouse | Mike Marshall | | 374 | 425 | -51 |
| 1978-07-22 | @ MIN | 95 | L 4-5 | 52-43 | 4 | 10,063 | Scott McGregor | Dave Goltz | Dave Goltz | Scott McGregor | | 378 | 430 | -52 |
| 1978-07-23 | @ MIN | 96 | W 8-5 | 53-43 | 4 | 30,896 | Jim Palmer | Gary Serum | Jim Palmer | Gary Serum | Don Stanhouse | 386 | 435 | -49 |
| 1978-07-24 | @ TEX | 97 | W 10-6 | 54-43 | 3 | 11,732 | Dennis Martinez | Fergie Jenkins | Don Stanhouse | Fergie Jenkins | Scott McGregor | 396 | 441 | -45 |
| 1978-07-25 | @ TEX | 98 | W 7-6 | 55-43 | 3 | 12,686 | Joe Kerrigan | Doyle Alexander | Joe Kerrigan | Doyle Alexander | Tippy Martinez | 403 | 447 | -44 |
| 1978-07-26 | @ DET | 99 | L 6-9 | 55-44 | 4 | 18,056 | Mike Flanagan | Jack Billingham | Jack Billingham | Mike Flanagan | Bob Sykes | 409 | 456 | -47 |
| 1978-07-27 | @ DET | 100 | W 7-3 | 56-44 | 3 | 22,856 | Scott McGregor | Jim Slaton | Scott McGregor | Jim Slaton | | 416 | 459 | -43 |
| 1978-07-28 | vs CAL | 101 | W 5-4 | 57-44 | 3 | 14,407 | Jim Palmer | Don Aase | Jim Palmer | Don Aase | Don Stanhouse | 421 | 463 | -42 |
| 1978-07-29 | vs CAL | 102 | L 1-2 | 57-45 | 3 | 23,504 | Dennis Martinez | Paul Hartzell | Paul Hartzell | Dennis Martinez | | 422 | 465 | -43 |
| 1978-07-30 | vs CAL | 103 | L 2-4 | 57-46 | 3 | 15,350 | Mike Flanagan | Dave Frost | Dave Frost | Mike Flanagan | Dave LaRoche | 424 | 469 | -45 |
| 1978-07-31 | vs MIL | 104 | W 6-5 | 58-46 | 3 | 10,514 | Scott McGregor | Bill Travers | Joe Kerrigan | Bill Castro | | 430 | 474 | -44 |
| 1978-08-02 | vs MIL | 105 | L 3-5 | 58-47 | 4 | 10,663 | Jim Palmer | Mike Caldwell | Mike Caldwell | Jim Palmer | Lary Sorensen | 433 | 479 | -46 |
| 1978-08-03 | vs MIL | 106 | W 3-2 | 59-47 | 3 | 9,654 | Dennis Martinez | Jerry Augustine | Dennis Martinez | Jerry Augustine | | 436 | 481 | -45 |
| 1978-08-04 | @ NYA | 107 | W 2-1 | 60-47 | 3 | 28,189 | Mike Flanagan | Ron Guidry | Mike Flanagan | Ron Guidry | Don Stanhouse | 438 | 482 | -44 |
| 1978-08-05 | @ NYA | 108 | L 2-3 | 60-48 | 3 | 26,727 | Scott McGregor | Ed Figueroa | Sparky Lyle | Tippy Martinez | | 440 | 485 | -45 |
| 1978-08-06 | @ NYA | 109 | L 0-3 | 60-49 | 4 | 40,765 | Jim Palmer | Catfish Hunter | Catfish Hunter | Jim Palmer | | 440 | 488 | -48 |
| 1978-08-07 | @ TOR | 110 | L 1-2 | 60-50 | 5 | 19,184 | Dennis Martinez | Jim Clancy | Jim Clancy | Dennis Martinez | | 441 | 490 | -49 |
| 1978-08-08 | @ TOR | 111 | L 3-5 | 60-51 | 5 | 19,052 | Mike Flanagan | Tom Underwood | Tom Underwood | Mike Flanagan | Victor Cruz | 444 | 495 | -51 |
| 1978-08-09 | vs KCA | 112 | L 0-2 | 60-52 | 5 | 12,859 | Scott McGregor | Larry Gura | Larry Gura | Scott McGregor | | 444 | 497 | -53 |
| 1978-08-10 | vs KCA | 113 | W 3-2 | 61-52 | 5 | 9,221 | Jim Palmer | Doug Bird | Jim Palmer | Doug Bird | Don Stanhouse | 447 | 499 | -52 |
| 1978-08-11 | vs NYA | 114 | L 1-2 | 61-53 | 5 | 29,539 | Dennis Martinez | Catfish Hunter | Catfish Hunter | Dennis Martinez | | 448 | 501 | -53 |
| 1978-08-12 | vs NYA | 115 | W 6-4 | 62-53 | 5 | 32,153 | Mike Flanagan | Jim Beattie | Mike Flanagan | Jim Beattie | Don Stanhouse | 454 | 505 | -51 |
| 1978-08-13 | vs NYA | 116 | W 3-0 | 63-53 | 5 | 31,591 | Scott McGregor | Ed Figueroa | Scott McGregor | Ed Figueroa | | 457 | 505 | -48 |
| 1978-08-14 | vs NYA | 117 | L 1-4 | 63-54 | 5 | 30,397 | Jim Palmer | Dick Tidrow | Rich Gossage | Jim Palmer | | 458 | 509 | -51 |
| 1978-08-15 | @ SEA | 118 | W 7-4 | 64-54 | 5 | 7,999 | Dennis Martinez | Glenn Abbott | Dennis Martinez | Glenn Abbott | Don Stanhouse | 465 | 513 | -48 |
| 1978-08-16 | @ SEA | 119 | L 5-7 | 64-55 | 5 | 6,619 | Mike Flanagan | Byron McLaughlin | Byron McLaughlin | Mike Flanagan | Jim Todd | 470 | 520 | -50 |
| 1978-08-18 | @ CAL | 120 | L 2-3 | 64-56 | 5 | 19,488 | Scott McGregor | Chris Knapp | Chris Knapp | Scott McGregor | | 472 | 523 | -51 |
| 1978-08-19 | @ CAL | 121 | L 3-4 | 64-57 | 5 | 38,870 | Jim Palmer | Paul Hartzell | Paul Hartzell | Jim Palmer | | 475 | 527 | -52 |
| 1978-08-20 | @ CAL | 122 | L 0-1 | 64-58 | 5 | 20,773 | Dennis Martinez | Nolan Ryan | Tom Griffin | Don Stanhouse | | 475 | 528 | -53 |
| 1978-08-21 | @ OAK | 123 | W 3-2 | 65-58 | 5 | 9,786 | Mike Flanagan | Rick Langford | Mike Flanagan | Rick Langford | | 478 | 530 | -52 |
| 1978-08-22 | @ OAK | 124 | W 6-4 | 66-58 | 5 | 1,930 | Scott McGregor | Pete Broberg | Don Stanhouse | Bob Lacey | Joe Kerrigan | 484 | 534 | -50 |
| 1978-08-23 | @ OAK | 125 | W 11-0 | 67-58 | 5 | 2,497 | Jim Palmer | Steve Renko | Jim Palmer | Steve Renko | | 495 | 534 | -39 |
| 1978-08-25 | vs SEA | 126 | W 5-0 | 68-58 | 5 | 10,538 | Dennis Martinez | Paul Mitchell | Dennis Martinez | Paul Mitchell | | 500 | 534 | -34 |
| 1978-08-26 | vs SEA | 127 | W 9-2 | 69-58 | 5 | 16,484 | Mike Flanagan | Jim Colborn | Mike Flanagan | Jim Colborn | Joe Kerrigan | 509 | 536 | -27 |
| 1978-08-27 | vs SEA | 128 | W 4-3 | 70-58 | 5 | 7,260 | Scott McGregor | Rick Honeycutt | Nelson Briles | Enrique Romo | | 513 | 539 | -26 |
| 1978-08-28 | vs OAK | 129 | W 7-3 | 71-58 | 5 | 6,000 | Jim Palmer | Steve Renko | Jim Palmer | Bob Lacey | | 520 | 542 | -22 |
| 1978-08-29 | vs OAK | 130 | W 6-2 | 72-58 | 5 | 4,995 | Dennis Martinez | Mike Norris | Dennis Martinez | Mike Norris | | 526 | 544 | -18 |
| 1978-08-30 | vs NYA | 131 | L 4-5 | 72-59 | 5 | 20,501 | Mike Flanagan | Ron Guidry | Ron Guidry | Tippy Martinez | Rich Gossage | 530 | 549 | -19 |
| 1978-08-31 | vs NYA | 132 | L 2-6 | 72-60 | 5 | 15,579 | Scott McGregor | Dick Tidrow | Dick Tidrow | Scott McGregor | Sparky Lyle | 532 | 555 | -23 |
| 1978-09-01 | vs CHA | 133 | W 3-0 | 74-60 | 5 | 0 | Jim Palmer | Steve Stone | Jim Palmer | Steve Stone | Don Stanhouse | 535 | 555 | -20 |
| 1978-09-01 | vs CHA | 134 | W 9-3 | 74-60 | 5 | 6,614 | Sammy Stewart | Ross Baumgarten | Sammy Stewart | Ross Baumgarten | Joe Kerrigan | 544 | 558 | -14 |
| 1978-09-02 | vs CHA | 135 | W 9-4 | 76-60 | 4 | 0 | Dennis Martinez | Ken Kravec | Dennis Martinez | Ken Kravec | | 553 | 562 | -9 |
| 1978-09-02 | vs CHA | 136 | W 1-0 | 76-60 | 4 | 10,696 | Dave Ford | Jack Kucek | Dave Ford | Jack Kucek | Tippy Martinez | 554 | 562 | -8 |
| 1978-09-03 | vs CHA | 137 | L 2-4 | 76-61 | 4 | 7,101 | Mike Flanagan | Rich Wortham | Lerrin LaGrow | Mike Flanagan | | 556 | 566 | -10 |
| 1978-09-04 | vs BOS | 138 | W 5-3 | 77-61 | 4 | 0 | Scott McGregor | Dennis Eckersley | Scott McGregor | Dennis Eckersley | Don Stanhouse | 561 | 569 | -8 |
| 1978-09-05 | vs BOS | 139 | W 4-1 | 78-61 | 4 | 15,644 | Jim Palmer | Bobby Sprowl | Jim Palmer | Bobby Sprowl | Don Stanhouse | 565 | 570 | -5 |
| 1978-09-06 | vs BOS | 140 | L 0-2 | 78-62 | 4 | 11,251 | Dennis Martinez | Luis Tiant | Luis Tiant | Dennis Martinez | | 565 | 572 | -7 |
| 1978-09-08 | @ TOR | 141 | W 5-4 | 79-62 | 4 | 14,155 | Mike Flanagan | Tom Underwood | Nelson Briles | Tom Underwood | Don Stanhouse | 570 | 576 | -6 |
| 1978-09-09 | @ TOR | 142 | W 4-0 | 80-62 | 4 | 29,255 | Scott McGregor | Balor Moore | Scott McGregor | Balor Moore | | 574 | 576 | -2 |
| 1978-09-11 | @ BOS | 143 | L 4-5 | 80-63 | 4 | 28,575 | Jim Palmer | Luis Tiant | Bob Stanley | Joe Kerrigan | | 578 | 581 | -3 |
| 1978-09-12 | @ BOS | 144 | W 3-2 | 81-63 | 4 | 28,924 | Dennis Martinez | Mike Torrez | Dennis Martinez | Mike Torrez | | 581 | 583 | -2 |
| 1978-09-13 | @ MIL | 145 | L 5-7 | 81-64 | 4 | 8,863 | Mike Flanagan | Andy Replogle | Andy Replogle | Mike Flanagan | Ed Farmer | 586 | 590 | -4 |
| 1978-09-14 | @ MIL | 146 | L 3-4 | 81-65 | 4 | 12,587 | Scott McGregor | Mike Caldwell | Mike Caldwell | Scott McGregor | | 589 | 594 | -5 |
| 1978-09-15 | vs TOR | 147 | W 8-3 | 82-65 | 4 | 4,000 | Jim Palmer | Jim Clancy | Jim Palmer | Victor Cruz | | 597 | 597 | 0 |
| 1978-09-16 | vs TOR | 148 | W 11-1 | 83-65 | 4 | 10,263 | Dennis Martinez | Jesse Jefferson | Dennis Martinez | Jesse Jefferson | | 608 | 598 | 10 |
| 1978-09-17 | vs TOR | 149 | W 5-0 | 84-65 | 4 | 4,436 | Mike Flanagan | Don Kirkwood | Mike Flanagan | Don Kirkwood | | 613 | 598 | 15 |
| 1978-09-18 | @ CLE | 150 | W 10-3 | 85-65 | 3 | 2,873 | Scott McGregor | David Clyde | Scott McGregor | David Clyde | | 623 | 601 | 22 |
| 1978-09-19 | @ CLE | 151 | L 1-2 | 85-66 | 4 | 3,148 | Jim Palmer | Mike Paxton | Mike Paxton | Don Stanhouse | | 624 | 603 | 21 |
| 1978-09-22 | vs DET | 152 | L 5-7 | 85-67 | 4 | 5,444 | Mike Flanagan | Kip Young | John Hiller | Mike Flanagan | | 629 | 610 | 19 |
| 1978-09-23 | vs DET | 153 | L 3-4 | 86-68 | 4 | 0 | Dennis Martinez | Jack Billingham | John Hiller | Don Stanhouse | | 632 | 614 | 18 |
| 1978-09-23 | vs DET | 154 | W 6-1 | 86-68 | 4 | 13,036 | Jim Palmer | Steve Baker | Jim Palmer | Steve Baker | | 638 | 615 | 23 |
| 1978-09-24 | vs DET | 155 | L 2-4 | 86-69 | 4 | 9,081 | Scott McGregor | Jim Slaton | Jim Slaton | Don Stanhouse | | 640 | 619 | 21 |
| 1978-09-26 | vs CLE | 156 | W 3-1 | 87-69 | 4 | 3,662 | Mike Flanagan | Paul Reuschel | Mike Flanagan | Paul Reuschel | Don Stanhouse | 643 | 620 | 23 |
| 1978-09-27 | vs CLE | 157 | W 3-1 | 88-69 | 4 | 2,987 | Dennis Martinez | Rick Waits | Dennis Martinez | Rick Waits | | 646 | 621 | 25 |
| 1978-09-28 | vs CLE | 158 | W 3-2 | 89-69 | 4 | 5,143 | Jim Palmer | Don Hood | Jim Palmer | Don Hood | Don Stanhouse | 649 | 623 | 26 |
| 1978-09-29 | @ DET | 159 | L 2-3 | 89-70 | 4 | 12,348 | Sammy Stewart | Jim Slaton | Jim Slaton | Sammy Stewart | John Hiller | 651 | 626 | 25 |
| 1978-09-30 | @ DET | 160 | L 4-5 | 89-71 | 4 | 13,919 | Mike Flanagan | Jack Morris | Steve Baker | Mike Flanagan | John Hiller | 655 | 631 | 24 |
| 1978-10-01 | @ DET | 161 | W 4-2 | 90-71 | 4 | 13,948 | Dennis Martinez | Dave Rozema | Dennis Martinez | Dave Rozema | | 659 | 633 | 26 |