| 1978-04-07 | vs OAK | 1 | W 1-0 | 1-0 | 2 | 28,194 | Frank Tanana | Rick Langford | Frank Tanana | Rick Langford | | 1 | 0 | 1 |
| 1978-04-08 | vs OAK | 2 | L 2-4 | 1-1 | 6 | 18,131 | Nolan Ryan | Matt Keough | Bob Lacey | Paul Hartzell | Dave Heaverlo | 3 | 4 | -1 |
| 1978-04-09 | vs OAK | 3 | W 3-2 | 2-1 | 2 | 15,975 | Chris Knapp | Alan Wirth | Chris Knapp | Alan Wirth | Dave LaRoche | 6 | 6 | 0 |
| 1978-04-10 | vs MIN | 4 | W 3-0 | 3-1 | 1 | 10,074 | Ken Brett | Dave Goltz | Ken Brett | Dave Goltz | | 9 | 6 | 3 |
| 1978-04-11 | vs MIN | 5 | L 1-8 | 3-2 | 4 | 12,217 | Don Aase | Roger Erickson | Roger Erickson | Don Aase | | 10 | 14 | -4 |
| 1978-04-12 | vs MIN | 6 | W 9-5 | 4-2 | 4 | 12,295 | Frank Tanana | Pete Redfern | Frank Tanana | Pete Redfern | Dave LaRoche | 19 | 19 | 0 |
| 1978-04-13 | vs MIN | 7 | W 1-0 | 5-2 | 3 | 11,702 | Nolan Ryan | Paul Thormodsgard | Dave LaRoche | Tom Johnson | | 20 | 19 | 1 |
| 1978-04-14 | @ OAK | 8 | L 1-2 | 5-3 | 4 | 2,973 | Chris Knapp | Alan Wirth | Dave Heaverlo | Chris Knapp | | 21 | 21 | 0 |
| 1978-04-16 | @ OAK | 9 | W 2-1 | 6-3 | 3 | 3,814 | Don Aase | John Henry Johnson | Dave LaRoche | Dave Heaverlo | Paul Hartzell | 23 | 22 | 1 |
| 1978-04-17 | @ SEA | 10 | W 7-3 | 7-3 | 3 | 7,562 | Frank Tanana | Rick Honeycutt | Frank Tanana | Rick Honeycutt | | 30 | 25 | 5 |
| 1978-04-18 | @ SEA | 11 | L 1-6 | 7-4 | 3 | 6,679 | Nolan Ryan | Paul Mitchell | Paul Mitchell | Nolan Ryan | | 31 | 31 | 0 |
| 1978-04-19 | @ SEA | 12 | W 11-2 | 8-4 | 3 | 7,181 | Chris Knapp | Glenn Abbott | Chris Knapp | Jim Todd | Paul Hartzell | 42 | 33 | 9 |
| 1978-04-21 | @ MIN | 13 | W 3-2 | 9-4 | 3 | 4,516 | Don Aase | Dave Goltz | Don Aase | Dave Goltz | Dave LaRoche | 45 | 35 | 10 |
| 1978-04-22 | @ MIN | 14 | W 5-3 | 10-4 | 3 | 6,566 | Frank Tanana | Roger Erickson | Frank Tanana | Roger Erickson | Paul Hartzell | 50 | 38 | 12 |
| 1978-04-24 | vs SEA | 15 | L 5-6 | 10-5 | 3 | 13,429 | Nolan Ryan | Mike Parrott | Enrique Romo | Paul Hartzell | Shane Rawley | 55 | 44 | 11 |
| 1978-04-25 | vs SEA | 16 | W 3-0 | 11-5 | 3 | 9,484 | Chris Knapp | Byron McLaughlin | Chris Knapp | Byron McLaughlin | Dave LaRoche | 58 | 44 | 14 |
| 1978-04-26 | vs SEA | 17 | L 4-5 | 11-6 | 3 | 11,868 | Ken Brett | Dick Pole | Dick Pole | Ken Brett | Shane Rawley | 62 | 49 | 13 |
| 1978-04-27 | vs SEA | 18 | W 5-1 | 12-6 | 3 | 13,609 | Frank Tanana | Jim Todd | Frank Tanana | Jim Todd | | 67 | 50 | 17 |
| 1978-04-28 | vs TOR | 19 | W 5-4 | 13-6 | 3 | 16,575 | Don Aase | Jesse Jefferson | Dyar Miller | Jesse Jefferson | Dave LaRoche | 72 | 54 | 18 |
| 1978-04-29 | vs TOR | 20 | W 5-0 | 14-6 | 3 | 24,354 | Nolan Ryan | Dave Lemanczyk | Nolan Ryan | Dave Lemanczyk | | 77 | 54 | 23 |
| 1978-04-30 | vs TOR | 21 | L 3-9 | 14-7 | 3 | 27,367 | Chris Knapp | Jerry Garvin | Jerry Garvin | Chris Knapp | | 80 | 63 | 17 |
| 1978-05-02 | vs DET | 22 | L 2-10 | 14-8 | 3 | 18,641 | Ken Brett | Milt Wilcox | Milt Wilcox | Ken Brett | | 82 | 73 | 9 |
| 1978-05-03 | vs DET | 23 | L 4-7 | 14-9 | 3 | 19,462 | Frank Tanana | Jim Slaton | Jim Slaton | Frank Tanana | John Hiller | 86 | 80 | 6 |
| 1978-05-05 | vs CLE | 24 | W 5-0 | 15-9 | 2 | 17,437 | Nolan Ryan | Rick Wise | Nolan Ryan | Rick Wise | | 91 | 80 | 11 |
| 1978-05-06 | vs CLE | 25 | W 7-3 | 16-9 | 2 | 40,750 | Chris Knapp | Mike Paxton | Chris Knapp | Mike Paxton | | 98 | 83 | 15 |
| 1978-05-07 | vs CLE | 26 | W 16-3 | 17-9 | 2 | 16,883 | Don Aase | Rick Waits | Don Aase | Rick Waits | Paul Hartzell | 114 | 86 | 28 |
| 1978-05-09 | @ DET | 27 | W 7-5 | 18-9 | 2 | 21,089 | Frank Tanana | Jim Slaton | Dave LaRoche | Steve Foucault | | 121 | 91 | 30 |
| 1978-05-12 | @ CLE | 28 | L 3-4 | 18-10 | 2 | 6,401 | Nolan Ryan | Mike Paxton | Mike Paxton | Nolan Ryan | Jim Kern | 124 | 95 | 29 |
| 1978-05-13 | @ CLE | 29 | L 1-2 | 18-11 | 2 | 13,811 | Chris Knapp | Rick Waits | Rick Waits | Chris Knapp | | 125 | 97 | 28 |
| 1978-05-14 | @ CLE | 30 | W 4-3 | 19-11 | 2 | 5,153 | Frank Tanana | Don Hood | Frank Tanana | Don Hood | Paul Hartzell | 129 | 100 | 29 |
| 1978-05-15 | @ TOR | 31 | L 6-10 | 19-12 | 2 | 11,295 | Ken Brett | Jerry Garvin | Balor Moore | Paul Hartzell | | 135 | 110 | 25 |
| 1978-05-16 | @ TOR | 32 | L 4-5 | 19-13 | 2 | 12,044 | Don Aase | Tom Underwood | Mike Willis | Don Aase | Tom Murphy | 139 | 115 | 24 |
| 1978-05-17 | @ CHA | 33 | L 6-9 | 19-14 | 2 | 13,676 | Nolan Ryan | Steve Stone | Steve Stone | Nolan Ryan | | 145 | 124 | 21 |
| 1978-05-18 | @ CHA | 34 | W 9-5 | 20-14 | 2 | 9,766 | Chris Knapp | Francisco Barrios | Chris Knapp | Francisco Barrios | Dave LaRoche | 154 | 129 | 25 |
| 1978-05-19 | @ MIL | 35 | W 7-1 | 21-14 | 2 | 13,843 | Frank Tanana | Mike Caldwell | Frank Tanana | Mike Caldwell | | 161 | 130 | 31 |
| 1978-05-20 | @ MIL | 36 | L 4-6 | 21-15 | 2 | 18,916 | Ken Brett | Bill Travers | Bill Travers | Ken Brett | Bill Castro | 165 | 136 | 29 |
| 1978-05-21 | @ MIL | 37 | L 1-2 | 21-16 | 2 | 42,376 | Don Aase | Lary Sorensen | Lary Sorensen | Dave LaRoche | | 166 | 138 | 28 |
| 1978-05-23 | vs CHA | 38 | W 5-4 | 22-16 | 2 | 16,866 | Nolan Ryan | Wilbur Wood | Nolan Ryan | Jim Willoughby | | 171 | 142 | 29 |
| 1978-05-24 | vs CHA | 39 | W 4-1 | 23-16 | 1 | 14,396 | Chris Knapp | Ken Kravec | Chris Knapp | Ken Kravec | | 175 | 143 | 32 |
| 1978-05-25 | vs CHA | 40 | W 6-0 | 24-16 | 1 | 15,910 | Frank Tanana | Ron Schueler | Frank Tanana | Ron Schueler | | 181 | 143 | 38 |
| 1978-05-26 | vs MIL | 41 | W 6-5 | 25-16 | 1 | 19,277 | Don Aase | Bill Travers | Paul Hartzell | Eduardo Rodriguez | | 187 | 148 | 39 |
| 1978-05-27 | vs MIL | 42 | L 2-4 | 25-17 | 2 | 29,097 | Tom Griffin | Lary Sorensen | Lary Sorensen | Tom Griffin | | 189 | 152 | 37 |
| 1978-05-28 | vs MIL | 43 | L 3-6 | 25-18 | 1 | 21,869 | Nolan Ryan | Andy Replogle | Andy Replogle | Nolan Ryan | Bob McClure | 192 | 158 | 34 |
| 1978-05-29 | @ CHA | 44 | L 0-7 | 25-19 | 2 | 15,411 | Chris Knapp | Pablo Torrealba | Pablo Torrealba | Chris Knapp | | 192 | 165 | 27 |
| 1978-05-30 | @ CHA | 45 | L 2-6 | 25-20 | 3 | 12,110 | Frank Tanana | Wilbur Wood | Wilbur Wood | Frank Tanana | Jim Willoughby | 194 | 171 | 23 |
| 1978-05-31 | @ CHA | 46 | L 2-17 | 25-21 | 3 | 12,828 | Don Aase | Steve Stone | Steve Stone | Don Aase | | 196 | 188 | 8 |
| 1978-06-02 | vs BOS | 47 | L 1-6 | 25-22 | 3 | 31,324 | Nolan Ryan | Luis Tiant | Luis Tiant | Nolan Ryan | Dick Drago | 197 | 194 | 3 |
| 1978-06-03 | vs BOS | 48 | L 4-5 | 25-23 | 3 | 34,228 | Chris Knapp | Mike Torrez | Mike Torrez | Paul Hartzell | Bill Campbell | 201 | 199 | 2 |
| 1978-06-04 | vs BOS | 49 | W 4-2 | 26-23 | 3 | 29,911 | Frank Tanana | Dennis Eckersley | Frank Tanana | Dennis Eckersley | Dave LaRoche | 205 | 201 | 4 |
| 1978-06-05 | vs BAL | 50 | L 2-6 | 26-24 | 3 | 13,231 | Don Aase | Jim Palmer | Don Stanhouse | Dave LaRoche | | 207 | 207 | 0 |
| 1978-06-06 | vs BAL | 51 | L 6-8 | 26-25 | 4 | 15,864 | Nolan Ryan | Dennis Martinez | Dennis Martinez | Nolan Ryan | Don Stanhouse | 213 | 215 | -2 |
| 1978-06-07 | @ OAK | 52 | W 4-1 | 27-26 | 4 | 0 | Ken Brett | Alan Wirth | Ken Brett | Alan Wirth | | 217 | 216 | 1 |
| 1978-06-07 | @ OAK | 53 | L 0-1 | 27-26 | 4 | 6,560 | Tom Griffin | Matt Keough | Matt Keough | Tom Griffin | Elias Sosa | 217 | 217 | 0 |
| 1978-06-08 | @ OAK | 54 | W 10-7 | 28-26 | 4 | 2,612 | Chris Knapp | John Henry Johnson | Dave LaRoche | Elias Sosa | | 227 | 224 | 3 |
| 1978-06-09 | vs NYA | 55 | L 1-3 | 28-27 | 4 | 29,415 | Frank Tanana | Ed Figueroa | Ed Figueroa | Frank Tanana | Rich Gossage | 228 | 227 | 1 |
| 1978-06-10 | vs NYA | 56 | W 4-3 | 29-27 | 4 | 37,848 | Nolan Ryan | Don Gullett | Dave LaRoche | Rich Gossage | | 232 | 230 | 2 |
| 1978-06-11 | vs NYA | 57 | W 9-6 | 30-27 | 3 | 31,646 | Don Aase | Dick Tidrow | Dyar Miller | Ken Clay | | 241 | 236 | 5 |
| 1978-06-12 | @ BOS | 58 | L 9-10 | 30-28 | 3 | 31,652 | Tom Griffin | Bill Lee | Bill Campbell | Dave LaRoche | | 250 | 246 | 4 |
| 1978-06-13 | @ BOS | 59 | L 0-5 | 30-29 | 4 | 26,539 | Chris Knapp | Jim Wright | Jim Wright | Chris Knapp | | 250 | 251 | -1 |
| 1978-06-14 | @ BAL | 60 | L 2-5 | 30-30 | 4 | 21,815 | Ken Brett | Jim Palmer | Jim Palmer | Ken Brett | | 252 | 256 | -4 |
| 1978-06-15 | @ BAL | 61 | W 5-1 | 31-30 | 4 | 15,004 | Frank Tanana | Scott McGregor | Frank Tanana | Scott McGregor | | 257 | 257 | 0 |
| 1978-06-16 | @ NYA | 62 | W 10-7 | 32-30 | 2 | 35,968 | Don Aase | Jim Beattie | Don Aase | Jim Beattie | | 267 | 264 | 3 |
| 1978-06-17 | @ NYA | 63 | L 0-4 | 32-31 | 2 | 33,162 | Paul Hartzell | Ron Guidry | Ron Guidry | Paul Hartzell | | 267 | 268 | -1 |
| 1978-06-18 | @ NYA | 64 | W 3-2 | 33-31 | 2 | 55,604 | Chris Knapp | Ed Figueroa | Chris Knapp | Ed Figueroa | | 270 | 270 | 0 |
| 1978-06-20 | @ MIN | 65 | W 10-5 | 34-31 | 2 | 12,330 | Frank Tanana | Roger Erickson | Frank Tanana | Roger Erickson | | 280 | 275 | 5 |
| 1978-06-21 | @ MIN | 66 | W 5-2 | 35-31 | 2 | 10,801 | Don Aase | Geoff Zahn | Don Aase | Geoff Zahn | | 285 | 277 | 8 |
| 1978-06-22 | @ MIN | 67 | W 4-2 | 36-31 | 2 | 7,488 | Ken Brett | Gary Serum | Dave LaRoche | Mike Marshall | | 289 | 279 | 10 |
| 1978-06-23 | @ TEX | 68 | L 0-7 | 36-33 | 3 | 0 | Chris Knapp | Fergie Jenkins | Fergie Jenkins | Chris Knapp | | 289 | 286 | 3 |
| 1978-06-23 | @ TEX | 69 | L 4-8 | 36-33 | 3 | 27,816 | Tom Griffin | Doyle Alexander | Doyle Alexander | Tom Griffin | Reggie Cleveland | 293 | 294 | -1 |
| 1978-06-24 | @ TEX | 70 | L 0-3 | 36-34 | 3 | 30,574 | Dave Frost | Jon Matlack | Jon Matlack | Dave Frost | | 293 | 297 | -4 |
| 1978-06-25 | @ TEX | 71 | L 0-7 | 36-35 | 3 | 22,821 | Don Aase | Doc Medich | Doc Medich | Don Aase | | 293 | 304 | -11 |
| 1978-06-26 | vs KCA | 72 | L 0-4 | 36-36 | 3 | 29,829 | Frank Tanana | Rich Gale | Rich Gale | Frank Tanana | | 293 | 308 | -15 |
| 1978-06-27 | vs KCA | 73 | W 5-4 | 37-36 | 3 | 21,459 | Ken Brett | Dennis Leonard | Tom Griffin | Steve Mingori | Dave LaRoche | 298 | 312 | -14 |
| 1978-06-28 | vs KCA | 74 | W 9-5 | 38-36 | 3 | 22,742 | Chris Knapp | Paul Splittorff | Chris Knapp | Paul Splittorff | Paul Hartzell | 307 | 317 | -10 |
| 1978-06-29 | vs KCA | 75 | W 3-1 | 39-36 | 3 | 17,038 | Dave Frost | Marty Pattin | Dave Frost | Al Hrabosky | Dave LaRoche | 310 | 318 | -8 |
| 1978-06-30 | vs TEX | 76 | W 4-2 | 40-36 | 2 | 21,654 | Don Aase | Jim Umbarger | Don Aase | Jim Umbarger | Dave LaRoche | 314 | 320 | -6 |
| 1978-07-01 | vs TEX | 77 | L 3-6 | 40-37 | 2 | 41,632 | Frank Tanana | Doc Medich | Doc Medich | Frank Tanana | Jon Matlack | 317 | 326 | -9 |
| 1978-07-02 | vs TEX | 78 | W 4-3 | 41-37 | 2 | 19,236 | Ken Brett | Dock Ellis | Dyar Miller | Steve Comer | | 321 | 329 | -8 |
| 1978-07-03 | @ KCA | 79 | W 7-4 | 42-37 | 1 | 39,928 | Chris Knapp | Doug Bird | Chris Knapp | Doug Bird | Dave LaRoche | 328 | 333 | -5 |
| 1978-07-04 | @ KCA | 80 | L 3-4 | 42-38 | 1 | 40,030 | Dave Frost | Rich Gale | Rich Gale | Paul Hartzell | | 331 | 337 | -6 |
| 1978-07-05 | @ KCA | 81 | L 1-10 | 42-39 | 3 | 20,347 | Nolan Ryan | Dennis Leonard | Dennis Leonard | Nolan Ryan | | 332 | 347 | -15 |
| 1978-07-06 | @ KCA | 82 | W 9-2 | 43-39 | 1 | 19,783 | Don Aase | Marty Pattin | Don Aase | Marty Pattin | | 341 | 349 | -8 |
| 1978-07-07 | vs SEA | 83 | W 9-5 | 44-39 | 1 | 20,119 | Frank Tanana | Dick Pole | Frank Tanana | Dick Pole | Dave LaRoche | 350 | 354 | -4 |
| 1978-07-08 | vs SEA | 84 | W 10-5 | 46-39 | 1 | 0 | Chris Knapp | Glenn Abbott | Chris Knapp | Glenn Abbott | Dave LaRoche | 360 | 359 | 1 |
| 1978-07-08 | vs SEA | 85 | W 5-0 | 46-39 | 1 | 32,020 | Dave Frost | Jim Colborn | Dave Frost | Jim Colborn | | 365 | 359 | 6 |
| 1978-07-09 | vs SEA | 86 | L 7-11 | 46-40 | 1 | 20,969 | Nolan Ryan | Rick Honeycutt | Enrique Romo | Nolan Ryan | | 372 | 370 | 2 |
| 1978-07-13 | vs TOR | 87 | W 5-0 | 47-40 | 1 | 16,625 | Don Aase | Dave Lemanczyk | Don Aase | Dave Lemanczyk | | 377 | 370 | 7 |
| 1978-07-14 | vs TOR | 88 | W 3-2 | 48-40 | 1 | 20,338 | Nolan Ryan | Jesse Jefferson | Dyar Miller | Mike Willis | | 380 | 372 | 8 |
| 1978-07-15 | vs DET | 89 | W 2-0 | 49-40 | 1 | 33,001 | Frank Tanana | Milt Wilcox | Frank Tanana | Milt Wilcox | | 382 | 372 | 10 |
| 1978-07-16 | vs DET | 90 | L 0-4 | 49-41 | 1 | 21,447 | Dave Frost | Jack Billingham | Jack Billingham | Dave Frost | | 382 | 376 | 6 |
| 1978-07-17 | vs DET | 91 | L 3-4 | 49-42 | 2 | 32,469 | John Caneira | Steve Baker | Jack Morris | Dave LaRoche | | 385 | 380 | 5 |
| 1978-07-18 | vs CLE | 92 | L 3-8 | 49-43 | 2 | 16,726 | Don Aase | Rick Waits | Rick Waits | Don Aase | Jim Kern | 388 | 388 | 0 |
| 1978-07-19 | vs CLE | 93 | W 3-0 | 50-43 | 2 | 18,584 | Nolan Ryan | Rick Wise | Nolan Ryan | Rick Wise | | 391 | 388 | 3 |
| 1978-07-21 | @ DET | 94 | W 4-2 | 51-44 | 2 | 0 | Frank Tanana | Milt Wilcox | Dave LaRoche | Kip Young | | 395 | 390 | 5 |
| 1978-07-21 | @ DET | 95 | L 0-5 | 51-44 | 2 | 33,699 | Dave Frost | Jack Billingham | Jack Billingham | Dave Frost | | 395 | 395 | 0 |
| 1978-07-22 | @ DET | 96 | L 3-7 | 51-45 | 2 | 31,107 | John Caneira | Jack Morris | Bob Sykes | Ken Brett | | 398 | 402 | -4 |
| 1978-07-23 | @ DET | 97 | L 3-4 | 52-46 | 2 | 0 | Don Aase | Dave Rozema | Steve Foucault | Dave LaRoche | | 401 | 406 | -5 |
| 1978-07-23 | @ DET | 98 | W 4-3 | 52-46 | 2 | 35,224 | Nolan Ryan | Jim Slaton | Nolan Ryan | Jim Slaton | | 405 | 409 | -4 |
| 1978-07-24 | @ CLE | 99 | W 5-4 | 53-46 | 2 | 8,798 | Paul Hartzell | Rick Wise | Tom Griffin | Jim Kern | | 410 | 413 | -3 |
| 1978-07-25 | @ CLE | 100 | L 1-5 | 53-47 | 2 | 6,781 | Dave Frost | Mike Paxton | Mike Paxton | Dave Frost | Dan Spillner | 411 | 418 | -7 |
| 1978-07-26 | @ MIL | 101 | W 11-9 | 54-47 | 2 | 21,584 | Frank Tanana | Bill Travers | Frank Tanana | Bill Travers | Dave LaRoche | 422 | 427 | -5 |
| 1978-07-27 | @ MIL | 102 | L 3-6 | 54-48 | 2 | 18,847 | Nolan Ryan | Mike Caldwell | Mike Caldwell | Nolan Ryan | | 425 | 433 | -8 |
| 1978-07-28 | @ BAL | 103 | L 4-5 | 54-49 | 2 | 14,407 | Don Aase | Jim Palmer | Jim Palmer | Don Aase | Don Stanhouse | 429 | 438 | -9 |
| 1978-07-29 | @ BAL | 104 | W 2-1 | 55-49 | 2 | 23,504 | Paul Hartzell | Dennis Martinez | Paul Hartzell | Dennis Martinez | | 431 | 439 | -8 |
| 1978-07-30 | @ BAL | 105 | W 4-2 | 56-49 | 2 | 15,350 | Dave Frost | Mike Flanagan | Dave Frost | Mike Flanagan | Dave LaRoche | 435 | 441 | -6 |
| 1978-07-31 | vs OAK | 106 | L 0-2 | 56-50 | 2 | 29,044 | Frank Tanana | Matt Keough | Matt Keough | Frank Tanana | Elias Sosa | 435 | 443 | -8 |
| 1978-08-01 | vs OAK | 107 | L 0-1 | 56-51 | 3 | 19,485 | Nolan Ryan | Rick Langford | Rick Langford | Nolan Ryan | | 435 | 444 | -9 |
| 1978-08-02 | vs OAK | 108 | W 8-2 | 57-51 | 2 | 16,898 | Don Aase | Pete Broberg | Don Aase | Pete Broberg | | 443 | 446 | -3 |
| 1978-08-03 | vs OAK | 109 | W 8-1 | 58-51 | 2 | 15,792 | Paul Hartzell | Steve Renko | Paul Hartzell | Steve Renko | | 451 | 447 | 4 |
| 1978-08-04 | vs MIN | 110 | W 12-3 | 59-51 | 2 | 17,411 | Al Fitzmorris | Dave Goltz | Al Fitzmorris | Gary Serum | Ken Brett | 463 | 450 | 13 |
| 1978-08-05 | vs MIN | 111 | L 3-4 | 60-52 | 2 | 0 | Frank Tanana | Roger Erickson | Roger Erickson | Frank Tanana | | 466 | 454 | 12 |
| 1978-08-05 | vs MIN | 112 | W 4-3 | 60-52 | 2 | 41,723 | Chris Knapp | Stan Perzanowski | Chris Knapp | Stan Perzanowski | Dave LaRoche | 470 | 457 | 13 |
| 1978-08-06 | vs MIN | 113 | W 4-3 | 61-52 | 2 | 17,628 | Nolan Ryan | Geoff Zahn | Dave LaRoche | Mike Marshall | | 474 | 460 | 14 |
| 1978-08-07 | @ OAK | 114 | L 0-1 | 61-53 | 2 | 17,183 | Don Aase | Steve Renko | Steve Renko | Don Aase | | 474 | 461 | 13 |
| 1978-08-08 | @ OAK | 115 | W 2-1 | 62-53 | 2 | 4,624 | Paul Hartzell | John Henry Johnson | Paul Hartzell | Dave Heaverlo | Dave LaRoche | 476 | 462 | 14 |
| 1978-08-10 | @ OAK | 116 | W 16-5 | 63-53 | 2 | 3,832 | Frank Tanana | Matt Keough | Frank Tanana | Matt Keough | | 492 | 467 | 25 |
| 1978-08-11 | @ SEA | 117 | W 3-1 | 64-53 | 2 | 0 | Nolan Ryan | Byron McLaughlin | Nolan Ryan | Byron McLaughlin | | 495 | 468 | 27 |
| 1978-08-12 | @ SEA | 118 | W 7-5 | 65-54 | 2 | 0 | Don Aase | Jim Colborn | Dave LaRoche | Jim Todd | | 502 | 473 | 29 |
| 1978-08-12 | @ SEA | 119 | L 3-5 | 65-54 | 2 | 15,833 | Chris Knapp | Paul Mitchell | Paul Mitchell | Chris Knapp | Mike Parrott | 505 | 478 | 27 |
| 1978-08-13 | @ SEA | 120 | L 1-4 | 65-55 | 2 | 10,229 | Paul Hartzell | Rick Honeycutt | Rick Honeycutt | Paul Hartzell | | 506 | 482 | 24 |
| 1978-08-15 | vs BOS | 121 | W 5-2 | 66-55 | 2 | 41,144 | Frank Tanana | Dennis Eckersley | Frank Tanana | Dennis Eckersley | | 511 | 484 | 27 |
| 1978-08-16 | vs BOS | 122 | L 2-4 | 66-56 | 2 | 37,535 | Nolan Ryan | Luis Tiant | Luis Tiant | Nolan Ryan | | 513 | 488 | 25 |
| 1978-08-17 | vs BOS | 123 | L 6-8 | 66-57 | 2 | 30,486 | Don Aase | Jim Wright | Bob Stanley | Tom Griffin | | 519 | 496 | 23 |
| 1978-08-18 | vs BAL | 124 | W 3-2 | 67-57 | 2 | 19,488 | Chris Knapp | Scott McGregor | Chris Knapp | Scott McGregor | | 522 | 498 | 24 |
| 1978-08-19 | vs BAL | 125 | W 4-3 | 68-57 | 2 | 38,870 | Paul Hartzell | Jim Palmer | Paul Hartzell | Jim Palmer | | 526 | 501 | 25 |
| 1978-08-20 | vs BAL | 126 | W 1-0 | 69-57 | 2 | 20,773 | Nolan Ryan | Dennis Martinez | Tom Griffin | Don Stanhouse | | 527 | 501 | 26 |
| 1978-08-22 | vs NYA | 127 | L 2-6 | 69-58 | 2 | 35,644 | Frank Tanana | Catfish Hunter | Catfish Hunter | Frank Tanana | | 529 | 507 | 22 |
| 1978-08-23 | vs NYA | 128 | W 6-3 | 70-58 | 2 | 33,472 | Chris Knapp | Ed Figueroa | Chris Knapp | Ed Figueroa | Dave LaRoche | 535 | 510 | 25 |
| 1978-08-25 | @ BOS | 129 | L 0-6 | 70-59 | 1 | 33,583 | Don Aase | Dennis Eckersley | Dennis Eckersley | Don Aase | | 535 | 516 | 19 |
| 1978-08-26 | @ BOS | 130 | L 1-7 | 70-60 | 1 | 33,531 | Paul Hartzell | Jim Wright | Jim Wright | Paul Hartzell | | 536 | 523 | 13 |
| 1978-08-27 | @ BOS | 131 | L 3-4 | 70-61 | 2 | 34,216 | Al Fitzmorris | Luis Tiant | Bob Stanley | Dyar Miller | | 539 | 527 | 12 |
| 1978-08-28 | @ NYA | 132 | L 1-4 | 70-62 | 2 | 22,481 | Frank Tanana | Ed Figueroa | Ed Figueroa | Frank Tanana | Rich Gossage | 540 | 531 | 9 |
| 1978-08-29 | @ NYA | 133 | L 3-4 | 70-63 | 2 | 24,203 | Chris Knapp | Jim Beattie | Rich Gossage | Dave LaRoche | | 543 | 535 | 8 |
| 1978-09-01 | @ TOR | 134 | W 6-4 | 71-63 | 2 | 16,757 | Paul Hartzell | Jesse Jefferson | Paul Hartzell | Jesse Jefferson | Dave LaRoche | 549 | 539 | 10 |
| 1978-09-02 | @ TOR | 135 | W 2-0 | 72-63 | 2 | 21,099 | Frank Tanana | Jim Clancy | Frank Tanana | Jim Clancy | | 551 | 539 | 12 |
| 1978-09-03 | @ TOR | 136 | W 3-1 | 73-63 | 2 | 20,054 | Chris Knapp | Tom Underwood | Chris Knapp | Tom Underwood | | 554 | 540 | 14 |
| 1978-09-04 | vs TEX | 137 | W 8-7 | 74-63 | 2 | 27,371 | Don Aase | Dock Ellis | Don Aase | Dock Ellis | Dave LaRoche | 562 | 547 | 15 |
| 1978-09-06 | vs TEX | 138 | L 5-11 | 74-65 | 2 | 0 | Nolan Ryan | Steve Comer | Steve Comer | Nolan Ryan | | 567 | 558 | 9 |
| 1978-09-06 | vs TEX | 139 | L 2-9 | 74-65 | 2 | 19,115 | Paul Hartzell | Fergie Jenkins | Fergie Jenkins | Paul Hartzell | | 569 | 567 | 2 |
| 1978-09-07 | vs TEX | 140 | W 7-6 | 75-65 | 2 | 15,815 | Frank Tanana | Doc Medich | Dyar Miller | Reggie Cleveland | Dave LaRoche | 576 | 573 | 3 |
| 1978-09-08 | vs KCA | 141 | L 7-9 | 75-66 | 2 | 26,507 | Chris Knapp | Larry Gura | Doug Bird | Dave LaRoche | | 583 | 582 | 1 |
| 1978-09-09 | vs KCA | 142 | W 3-2 | 77-66 | 2 | 0 | Don Aase | Rich Gale | Don Aase | Rich Gale | Dave LaRoche | 586 | 584 | 2 |
| 1978-09-09 | vs KCA | 143 | W 4-2 | 77-66 | 2 | 41,511 | Dave Frost | Dennis Leonard | Dave Frost | Dennis Leonard | | 590 | 586 | 4 |
| 1978-09-10 | vs KCA | 144 | W 13-3 | 78-66 | 2 | 24,793 | Nolan Ryan | Paul Splittorff | Nolan Ryan | Paul Splittorff | | 603 | 589 | 14 |
| 1978-09-11 | @ TEX | 145 | L 0-1 | 78-67 | 2 | 7,245 | Paul Hartzell | Fergie Jenkins | Fergie Jenkins | Paul Hartzell | | 603 | 590 | 13 |
| 1978-09-12 | @ TEX | 146 | L 5-7 | 78-68 | 2 | 8,469 | Frank Tanana | Doc Medich | Doc Medich | Frank Tanana | Reggie Cleveland | 608 | 597 | 11 |
| 1978-09-13 | @ TEX | 147 | L 4-6 | 78-69 | 2 | 7,565 | Chris Knapp | Jon Matlack | Reggie Cleveland | Dave LaRoche | | 612 | 603 | 9 |
| 1978-09-14 | @ TEX | 148 | W 16-1 | 79-69 | 2 | 8,261 | Don Aase | Dock Ellis | Don Aase | Dock Ellis | | 628 | 604 | 24 |
| 1978-09-15 | @ KCA | 149 | L 2-3 | 79-70 | 2 | 30,847 | Nolan Ryan | Rich Gale | Al Hrabosky | Nolan Ryan | | 630 | 607 | 23 |
| 1978-09-16 | @ KCA | 150 | W 4-3 | 80-70 | 2 | 40,237 | Paul Hartzell | Marty Pattin | Dyar Miller | Al Hrabosky | Dave LaRoche | 634 | 610 | 24 |
| 1978-09-17 | @ KCA | 151 | L 0-5 | 80-71 | 2 | 37,590 | Frank Tanana | Dennis Leonard | Dennis Leonard | Frank Tanana | | 634 | 615 | 19 |
| 1978-09-18 | @ MIN | 152 | L 4-10 | 80-72 | 2 | 2,278 | Chris Knapp | Geoff Zahn | Geoff Zahn | Chris Knapp | Stan Perzanowski | 638 | 625 | 13 |
| 1978-09-19 | @ MIN | 153 | W 4-1 | 81-72 | 2 | 3,747 | Nolan Ryan | Roger Erickson | Nolan Ryan | Roger Erickson | | 642 | 626 | 16 |
| 1978-09-22 | @ CHA | 154 | W 3-2 | 82-72 | 2 | 13,922 | Frank Tanana | Rich Hinton | Frank Tanana | Rich Hinton | Dave LaRoche | 645 | 628 | 17 |
| 1978-09-23 | @ CHA | 155 | L 4-5 | 82-73 | 2 | 7,953 | Chris Knapp | Rich Wortham | Lerrin LaGrow | Dyar Miller | | 649 | 633 | 16 |
| 1978-09-24 | @ CHA | 156 | W 7-3 | 83-73 | 2 | 12,621 | Nolan Ryan | Francisco Barrios | Nolan Ryan | Francisco Barrios | | 656 | 636 | 20 |
| 1978-09-26 | vs MIL | 157 | W 4-3 | 84-73 | 2 | 12,646 | Don Aase | Lary Sorensen | Dave LaRoche | Lary Sorensen | | 660 | 639 | 21 |
| 1978-09-27 | vs MIL | 158 | W 4-1 | 85-73 | 2 | 12,302 | Dave Frost | Andy Replogle | Dave Frost | Andy Replogle | Dave LaRoche | 664 | 640 | 24 |
| 1978-09-28 | vs CHA | 159 | W 11-7 | 86-73 | 2 | 11,659 | Nolan Ryan | Rich Hinton | Ken Brett | Rich Hinton | Dyar Miller | 675 | 647 | 28 |
| 1978-09-29 | vs CHA | 160 | L 6-9 | 86-74 | 2 | 14,811 | Frank Tanana | Steve Trout | Steve Trout | Frank Tanana | Jack Kucek | 681 | 656 | 25 |
| 1978-09-30 | vs CHA | 161 | L 5-6 | 86-75 | 3 | 16,919 | Chris Knapp | Rich Wortham | Lerrin LaGrow | Dave LaRoche | | 686 | 662 | 24 |
| 1978-10-01 | vs CHA | 162 | W 5-4 | 87-75 | 3 | 31,327 | Nolan Ryan | Francisco Barrios | Nolan Ryan | Francisco Barrios | | 691 | 666 | 25 |