| 1978-04-07 | vs LAN | 1 | L 4-13 | 0-1 | 4 | 42,866 | Phil Niekro | Don Sutton | Don Sutton | Phil Niekro | | 4 | 13 | -9 |
| 1978-04-08 | vs LAN | 2 | L 2-6 | 0-2 | 5 | 11,265 | Dick Ruthven | Tommy John | Tommy John | Dick Ruthven | Terry Forster | 6 | 19 | -13 |
| 1978-04-09 | vs LAN | 3 | L 4-7 | 0-3 | 5 | 11,473 | Tommy Boggs | Rick Rhoden | Rick Rhoden | Tommy Boggs | Bobby Castillo | 10 | 26 | -16 |
| 1978-04-10 | vs SDN | 4 | W 8-7 | 1-3 | 4 | 2,056 | Preston Hanna | Dave Freisleben | Adrian Devine | Bob Shirley | | 18 | 33 | -15 |
| 1978-04-11 | vs SDN | 5 | L 2-3 | 1-4 | 5 | 2,616 | Phil Niekro | Bob Owchinko | Rollie Fingers | Phil Niekro | | 20 | 36 | -16 |
| 1978-04-14 | @ LAN | 6 | L 1-5 | 1-5 | 6 | 38,397 | Dick Ruthven | Tommy John | Tommy John | Dick Ruthven | | 21 | 41 | -20 |
| 1978-04-16 | @ LAN | 7 | L 0-8 | 1-6 | 6 | 37,161 | Phil Niekro | Rick Rhoden | Rick Rhoden | Phil Niekro | | 21 | 49 | -28 |
| 1978-04-17 | @ SFN | 8 | L 1-5 | 1-7 | 6 | 5,882 | Tommy Boggs | Vida Blue | Vida Blue | Tommy Boggs | | 22 | 54 | -32 |
| 1978-04-18 | @ SFN | 9 | W 1-0 | 2-7 | 6 | 7,401 | Preston Hanna | John Montefusco | Preston Hanna | John Montefusco | Adrian Devine | 23 | 54 | -31 |
| 1978-04-19 | @ SFN | 10 | W 2-0 | 3-7 | 5 | 3,689 | Dick Ruthven | Jim Barr | Dick Ruthven | Jim Barr | | 25 | 54 | -29 |
| 1978-04-20 | @ SDN | 11 | L 0-2 | 3-8 | 6 | 10,256 | Phil Niekro | Randy Jones | Randy Jones | Phil Niekro | Rollie Fingers | 25 | 56 | -31 |
| 1978-04-21 | @ SDN | 12 | L 3-9 | 3-9 | 6 | 37,113 | Jamie Easterly | Gaylord Perry | Gaylord Perry | Jamie Easterly | | 28 | 65 | -37 |
| 1978-04-22 | @ SDN | 13 | L 0-2 | 3-10 | 6 | 49,744 | Tommy Boggs | Bob Owchinko | Bob Owchinko | Tommy Boggs | Rollie Fingers | 28 | 67 | -39 |
| 1978-04-23 | @ SDN | 14 | L 4-5 | 3-11 | 6 | 19,502 | Dick Ruthven | Bob Shirley | Dave Wehrmeister | Eddie Solomon | | 32 | 72 | -40 |
| 1978-04-25 | vs SFN | 15 | W 3-1 | 4-11 | 6 | 2,193 | Phil Niekro | Jim Barr | Phil Niekro | Jim Barr | | 35 | 73 | -38 |
| 1978-04-26 | vs SFN | 16 | W 6-1 | 5-11 | 6 | 3,284 | Preston Hanna | Bob Knepper | Preston Hanna | Bob Knepper | Eddie Solomon | 41 | 74 | -33 |
| 1978-04-27 | vs SFN | 17 | L 3-5 | 5-12 | 6 | 3,527 | Dick Ruthven | Vida Blue | Vida Blue | Dick Ruthven | | 44 | 79 | -35 |
| 1978-04-28 | vs CHN | 18 | L 3-4 | 5-13 | 6 | 10,045 | Jamie Easterly | Ray Burris | Bruce Sutter | Dave Campbell | Donnie Moore | 47 | 83 | -36 |
| 1978-04-29 | vs CHN | 19 | W 5-0 | 6-13 | 6 | 7,638 | Phil Niekro | Woodie Fryman | Phil Niekro | Woodie Fryman | | 52 | 83 | -31 |
| 1978-04-30 | vs CHN | 20 | L 5-7 | 6-14 | 6 | 7,269 | Tommy Boggs | Dennis Lamp | Bruce Sutter | Adrian Devine | | 57 | 90 | -33 |
| 1978-05-01 | vs NYN | 21 | W 6-5 | 7-14 | 6 | 5,399 | Preston Hanna | Craig Swan | Eddie Solomon | Skip Lockwood | | 63 | 95 | -32 |
| 1978-05-02 | vs NYN | 22 | W 5-4 | 8-14 | 6 | 4,682 | Dick Ruthven | Mike Bruhert | Adrian Devine | Bob Myrick | | 68 | 99 | -31 |
| 1978-05-04 | vs NYN | 23 | L 2-8 | 8-15 | 6 | 6,195 | Phil Niekro | Jerry Koosman | Jerry Koosman | Phil Niekro | | 70 | 107 | -37 |
| 1978-05-05 | vs HOU | 24 | W 5-2 | 9-15 | 6 | 5,699 | Tommy Boggs | Joe Niekro | Tommy Boggs | Joe Niekro | Eddie Solomon | 75 | 109 | -34 |
| 1978-05-06 | vs HOU | 25 | W 2-1 | 10-15 | 5 | 7,901 | Preston Hanna | Joaquin Andujar | Dave Campbell | Ken Forsch | | 77 | 110 | -33 |
| 1978-05-09 | vs MON | 26 | W 3-2 | 11-16 | 5 | 0 | Dick Ruthven | Steve Rogers | Dave Campbell | Bill Atkinson | | 80 | 112 | -32 |
| 1978-05-09 | vs MON | 27 | L 6-7 | 11-16 | 5 | 8,636 | Phil Niekro | Hal Dues | Bill Atkinson | Eddie Solomon | | 86 | 119 | -33 |
| 1978-05-12 | @ MON | 28 | L 3-5 | 11-17 | 6 | 8,522 | Preston Hanna | Ross Grimsley | Ross Grimsley | Rick Camp | Stan Bahnsen | 89 | 124 | -35 |
| 1978-05-13 | @ MON | 29 | L 0-3 | 11-18 | 6 | 10,147 | Phil Niekro | Steve Rogers | Steve Rogers | Phil Niekro | | 89 | 127 | -38 |
| 1978-05-14 | @ MON | 30 | W 2-1 | 12-18 | 6 | 13,925 | Dick Ruthven | Rudy May | Dick Ruthven | Rudy May | | 91 | 128 | -37 |
| 1978-05-17 | @ NYN | 31 | W 2-1 | 13-19 | 6 | 0 | Phil Niekro | Jerry Koosman | Phil Niekro | Jerry Koosman | | 93 | 129 | -36 |
| 1978-05-17 | @ NYN | 32 | L 1-3 | 13-19 | 6 | 4,054 | Tommy Boggs | Nino Espinosa | Nino Espinosa | Tommy Boggs | | 94 | 132 | -38 |
| 1978-05-18 | @ NYN | 33 | L 7-8 | 13-20 | 6 | 4,431 | Preston Hanna | Pat Zachry | Skip Lockwood | Eddie Solomon | | 101 | 140 | -39 |
| 1978-05-19 | @ HOU | 34 | L 0-6 | 13-21 | 6 | 15,609 | Dick Ruthven | Floyd Bannister | Floyd Bannister | Dick Ruthven | | 101 | 146 | -45 |
| 1978-05-20 | @ HOU | 35 | L 0-13 | 13-22 | 6 | 24,402 | Tommy Boggs | J.R. Richard | J.R. Richard | Tommy Boggs | | 101 | 159 | -58 |
| 1978-05-21 | @ HOU | 36 | W 6-4 | 14-22 | 6 | 11,715 | Phil Niekro | Mark Lemongello | Phil Niekro | Mark Lemongello | Adrian Devine | 107 | 163 | -56 |
| 1978-05-22 | @ CIN | 37 | L 0-10 | 14-23 | 6 | 18,434 | Mickey Mahler | Bill Bonham | Bill Bonham | Mickey Mahler | | 107 | 173 | -66 |
| 1978-05-23 | @ CIN | 38 | W 6-4 | 15-23 | 6 | 17,771 | Preston Hanna | Fred Norman | Preston Hanna | Fred Norman | Adrian Devine | 113 | 177 | -64 |
| 1978-05-24 | @ CIN | 39 | L 4-5 | 15-24 | 6 | 23,891 | Jamie Easterly | Paul Moskau | Manny Sarmiento | Adrian Devine | | 117 | 182 | -65 |
| 1978-05-26 | vs PHI | 40 | W 4-2 | 16-24 | 6 | 16,638 | Phil Niekro | Randy Lerch | Phil Niekro | Randy Lerch | | 121 | 184 | -63 |
| 1978-05-27 | vs PHI | 41 | L 5-6 | 16-25 | 6 | 15,081 | Dick Ruthven | Jim Lonborg | Tug McGraw | Rick Camp | Gene Garber | 126 | 190 | -64 |
| 1978-05-28 | vs PHI | 42 | W 5-3 | 17-25 | 6 | 22,233 | Preston Hanna | Larry Christenson | Preston Hanna | Larry Christenson | Jamie Easterly | 131 | 193 | -62 |
| 1978-05-29 | vs CIN | 43 | L 5-7 | 17-26 | 6 | 12,569 | Mickey Mahler | Paul Moskau | Manny Sarmiento | Jamie Easterly | Doug Bair | 136 | 200 | -64 |
| 1978-05-30 | vs CIN | 44 | W 4-3 | 18-26 | 6 | 10,103 | Phil Niekro | Tom Hume | Jamie Easterly | Doug Bair | | 140 | 203 | -63 |
| 1978-05-31 | vs CIN | 45 | L 4-10 | 18-27 | 6 | 10,933 | Dick Ruthven | Tom Seaver | Tom Seaver | Dick Ruthven | | 144 | 213 | -69 |
| 1978-06-02 | @ CHN | 46 | L 1-2 | 18-28 | 6 | 10,177 | Preston Hanna | Dave Roberts | Donnie Moore | Jamie Easterly | | 145 | 215 | -70 |
| 1978-06-03 | @ CHN | 47 | L 6-8 | 18-29 | 6 | 30,362 | Phil Niekro | Ray Burris | Donnie Moore | Jamie Easterly | Bruce Sutter | 151 | 223 | -72 |
| 1978-06-04 | @ CHN | 48 | L 4-6 | 18-30 | 6 | 29,845 | Mickey Mahler | Rick Reuschel | Rick Reuschel | Mickey Mahler | | 155 | 229 | -74 |
| 1978-06-05 | @ PIT | 49 | W 8-4 | 19-30 | 6 | 5,248 | Dick Ruthven | John Candelaria | Jamie Easterly | Kent Tekulve | | 163 | 233 | -70 |
| 1978-06-06 | @ PIT | 50 | L 2-4 | 19-31 | 6 | 4,914 | Adrian Devine | Jim Bibby | Jim Bibby | Adrian Devine | Kent Tekulve | 165 | 237 | -72 |
| 1978-06-07 | @ SLN | 51 | W 6-0 | 20-31 | 6 | 10,756 | Phil Niekro | Pete Falcone | Phil Niekro | Pete Falcone | | 171 | 237 | -66 |
| 1978-06-08 | @ SLN | 52 | L 0-2 | 20-32 | 6 | 11,576 | Preston Hanna | Pete Vuckovich | Pete Vuckovich | Preston Hanna | Mark Littell | 171 | 239 | -68 |
| 1978-06-09 | @ PHI | 53 | L 1-6 | 20-33 | 6 | 40,272 | Eddie Solomon | Larry Christenson | Larry Christenson | Eddie Solomon | | 172 | 245 | -73 |
| 1978-06-10 | @ PHI | 54 | L 2-6 | 20-34 | 6 | 33,292 | Dick Ruthven | Jim Kaat | Jim Kaat | Dick Ruthven | Gene Garber | 174 | 251 | -77 |
| 1978-06-11 | @ PHI | 55 | W 4-0 | 21-34 | 6 | 58,367 | Phil Niekro | Steve Carlton | Phil Niekro | Steve Carlton | | 178 | 251 | -73 |
| 1978-06-12 | vs SLN | 56 | W 2-1 | 22-34 | 6 | 7,970 | Mickey Mahler | Pete Vuckovich | Mickey Mahler | Pete Vuckovich | | 180 | 252 | -72 |
| 1978-06-13 | vs SLN | 57 | W 12-1 | 23-34 | 6 | 7,384 | Preston Hanna | Silvio Martinez | Preston Hanna | Silvio Martinez | | 192 | 253 | -61 |
| 1978-06-14 | vs SLN | 58 | W 7-1 | 24-34 | 6 | 6,463 | Adrian Devine | Bob Forsch | Adrian Devine | Bob Forsch | | 199 | 254 | -55 |
| 1978-06-16 | vs PIT | 59 | L 4-9 | 24-35 | 6 | 18,572 | Phil Niekro | Bert Blyleven | Bert Blyleven | Phil Niekro | Ed Whitson | 203 | 263 | -60 |
| 1978-06-17 | vs PIT | 60 | L 3-5 | 24-36 | 6 | 16,284 | Mickey Mahler | John Candelaria | John Candelaria | Mickey Mahler | Grant Jackson | 206 | 268 | -62 |
| 1978-06-18 | vs PIT | 61 | W 8-7 | 25-36 | 6 | 21,498 | Preston Hanna | Jim Bibby | Preston Hanna | Jim Bibby | Craig Skok | 214 | 275 | -61 |
| 1978-06-20 | @ SDN | 62 | W 5-3 | 26-36 | 6 | 13,059 | Phil Niekro | Randy Jones | Phil Niekro | Randy Jones | Gene Garber | 219 | 278 | -59 |
| 1978-06-21 | @ SDN | 63 | W 2-0 | 27-36 | 6 | 12,016 | Adrian Devine | Bob Shirley | Adrian Devine | Bob Shirley | Gene Garber | 221 | 278 | -57 |
| 1978-06-22 | @ SDN | 64 | L 0-2 | 27-37 | 6 | 8,854 | Mickey Mahler | Bob Owchinko | Bob Owchinko | Mickey Mahler | Rollie Fingers | 221 | 280 | -59 |
| 1978-06-23 | @ SFN | 65 | L 0-9 | 27-38 | 6 | 9,267 | Preston Hanna | Vida Blue | Vida Blue | Preston Hanna | | 221 | 289 | -68 |
| 1978-06-24 | @ SFN | 66 | L 1-2 | 27-39 | 6 | 10,578 | Phil Niekro | Jim Barr | Jim Barr | Phil Niekro | | 222 | 291 | -69 |
| 1978-06-25 | @ SFN | 67 | L 3-9 | 28-40 | 6 | 0 | Preston Hanna | John Montefusco | John Montefusco | Preston Hanna | | 225 | 300 | -75 |
| 1978-06-25 | @ SFN | 68 | W 8-4 | 28-40 | 6 | 41,090 | Mickey Mahler | Ed Halicki | Craig Skok | Randy Moffitt | | 233 | 304 | -71 |
| 1978-06-26 | vs LAN | 69 | W 5-2 | 29-40 | 6 | 8,991 | Adrian Devine | Rick Rhoden | Adrian Devine | Rick Rhoden | Gene Garber | 238 | 306 | -68 |
| 1978-06-27 | vs LAN | 70 | L 0-3 | 29-41 | 6 | 26,245 | Rick Camp | Doug Rau | Doug Rau | Dave Campbell | | 238 | 309 | -71 |
| 1978-06-28 | vs LAN | 71 | L 2-3 | 29-42 | 6 | 7,624 | Phil Niekro | Burt Hooton | Burt Hooton | Phil Niekro | Terry Forster | 240 | 312 | -72 |
| 1978-06-29 | vs LAN | 72 | L 3-7 | 29-43 | 6 | 7,408 | Preston Hanna | Don Sutton | Don Sutton | Preston Hanna | | 243 | 319 | -76 |
| 1978-06-30 | vs SFN | 73 | W 10-9 | 31-43 | 6 | 0 | Jamie Easterly | John Montefusco | Gene Garber | Gary Lavelle | | 253 | 328 | -75 |
| 1978-06-30 | vs SFN | 74 | W 10-5 | 31-43 | 6 | 14,429 | Mickey Mahler | Ed Halicki | Mickey Mahler | Ed Halicki | | 263 | 333 | -70 |
| 1978-07-01 | vs SFN | 75 | L 4-15 | 31-44 | 6 | 34,654 | Adrian Devine | Bob Knepper | Bob Knepper | Adrian Devine | | 267 | 348 | -81 |
| 1978-07-02 | vs SFN | 76 | W 9-7 | 32-44 | 6 | 13,588 | Phil Niekro | Vida Blue | Phil Niekro | Randy Moffitt | Gene Garber | 276 | 355 | -79 |
| 1978-07-03 | @ LAN | 77 | W 4-2 | 33-44 | 6 | 52,190 | Rick Camp | Burt Hooton | Rick Camp | Burt Hooton | Gene Garber | 280 | 357 | -77 |
| 1978-07-04 | @ LAN | 78 | L 1-4 | 33-45 | 6 | 49,691 | Preston Hanna | Don Sutton | Don Sutton | Preston Hanna | Bob Welch | 281 | 361 | -80 |
| 1978-07-05 | @ LAN | 79 | W 9-8 | 34-45 | 6 | 39,036 | Adrian Devine | Tommy John | Dave Campbell | Charlie Hough | Gene Garber | 290 | 369 | -79 |
| 1978-07-06 | @ LAN | 80 | L 1-5 | 34-46 | 6 | 18,355 | Phil Niekro | Rick Rhoden | Charlie Hough | Craig Skok | | 291 | 374 | -83 |
| 1978-07-07 | vs SDN | 81 | W 11-3 | 35-46 | 6 | 9,605 | Mickey Mahler | Gaylord Perry | Mickey Mahler | Gaylord Perry | | 302 | 377 | -75 |
| 1978-07-08 | vs SDN | 82 | W 6-4 | 36-47 | 5 | 0 | Rick Camp | Randy Jones | Craig Skok | John D'Acquisto | Gene Garber | 308 | 381 | -73 |
| 1978-07-08 | vs SDN | 83 | L 0-7 | 36-47 | 5 | 18,794 | Jamie Easterly | Eric Rasmussen | Eric Rasmussen | Jamie Easterly | | 308 | 388 | -80 |
| 1978-07-09 | vs SDN | 84 | W 5-2 | 37-47 | 5 | 8,621 | Preston Hanna | Bob Shirley | Preston Hanna | Bob Shirley | Gene Garber | 313 | 390 | -77 |
| 1978-07-14 | vs PHI | 85 | W 7-2 | 38-47 | 5 | 17,464 | Phil Niekro | Steve Carlton | Phil Niekro | Steve Carlton | | 320 | 392 | -72 |
| 1978-07-15 | vs PHI | 86 | W 3-2 | 39-47 | 5 | 0 | Rick Camp | Jim Kaat | Rick Camp | Jim Kaat | Gene Garber | 323 | 394 | -71 |
| 1978-07-16 | vs PHI | 87 | L 2-4 | 39-48 | 5 | 20,734 | Preston Hanna | Dick Ruthven | Dick Ruthven | Preston Hanna | Ron Reed | 325 | 398 | -73 |
| 1978-07-17 | vs NYN | 88 | W 3-0 | 40-49 | 5 | 0 | Larry McWilliams | Nino Espinosa | Larry McWilliams | Nino Espinosa | Gene Garber | 328 | 398 | -70 |
| 1978-07-17 | vs NYN | 89 | L 4-7 | 40-49 | 5 | 11,822 | Mickey Mahler | Tom Hausman | Tom Hausman | Mickey Mahler | Skip Lockwood | 332 | 405 | -73 |
| 1978-07-18 | vs NYN | 90 | W 4-3 | 41-49 | 5 | 10,902 | Phil Niekro | Jerry Koosman | Phil Niekro | Jerry Koosman | | 336 | 408 | -72 |
| 1978-07-19 | @ MON | 91 | L 6-8 | 42-50 | 5 | 0 | Tommy Boggs | Rudy May | Mike Garman | Gene Garber | | 342 | 416 | -74 |
| 1978-07-19 | @ MON | 92 | W 3-1 | 42-50 | 5 | 20,282 | Eddie Solomon | Wayne Twitchell | Eddie Solomon | Wayne Twitchell | Dave Campbell | 345 | 417 | -72 |
| 1978-07-20 | @ MON | 93 | L 3-7 | 42-51 | 5 | 14,108 | Jamie Easterly | Woodie Fryman | Woodie Fryman | Jamie Easterly | Mike Garman | 348 | 424 | -76 |
| 1978-07-21 | @ NYN | 94 | L 3-12 | 42-52 | 5 | 10,636 | Preston Hanna | Nino Espinosa | Nino Espinosa | Preston Hanna | | 351 | 436 | -85 |
| 1978-07-22 | @ NYN | 95 | L 0-2 | 42-53 | 5 | 12,277 | Phil Niekro | Tom Hausman | Tom Hausman | Phil Niekro | Skip Lockwood | 351 | 438 | -87 |
| 1978-07-23 | @ NYN | 96 | W 3-0 | 43-53 | 5 | 10,684 | Larry McWilliams | Jerry Koosman | Larry McWilliams | Jerry Koosman | Gene Garber | 354 | 438 | -84 |
| 1978-07-24 | @ PHI | 97 | W 5-1 | 44-53 | 5 | 30,184 | Eddie Solomon | Jim Lonborg | Eddie Solomon | Jim Lonborg | Craig Skok | 359 | 439 | -80 |
| 1978-07-25 | @ PHI | 98 | W 4-0 | 45-53 | 5 | 25,954 | Tommy Boggs | Larry Christenson | Tommy Boggs | Larry Christenson | | 363 | 439 | -76 |
| 1978-07-26 | @ PHI | 99 | W 4-2 | 46-53 | 5 | 50,218 | Phil Niekro | Jim Kaat | Phil Niekro | Jim Kaat | | 367 | 441 | -74 |
| 1978-07-28 | vs MON | 100 | W 6-4 | 47-54 | 5 | 0 | Larry McWilliams | Steve Rogers | Dave Campbell | Gerry Pirtle | Gene Garber | 373 | 445 | -72 |
| 1978-07-28 | vs MON | 101 | L 1-4 | 47-54 | 5 | 23,297 | Preston Hanna | Dan Schatzeder | Dan Schatzeder | Preston Hanna | Mike Garman | 374 | 449 | -75 |
| 1978-07-29 | vs MON | 102 | W 9-6 | 48-54 | 5 | 16,734 | Mickey Mahler | Stan Bahnsen | Jamie Easterly | Mike Garman | Phil Niekro | 383 | 455 | -72 |
| 1978-07-30 | vs MON | 103 | L 0-19 | 48-55 | 5 | 10,834 | Tommy Boggs | Woodie Fryman | Woodie Fryman | Tommy Boggs | | 383 | 474 | -91 |
| 1978-07-31 | vs CIN | 104 | L 2-3 | 48-56 | 5 | 45,007 | Phil Niekro | Mike LaCoss | Mike LaCoss | Phil Niekro | Doug Bair | 385 | 477 | -92 |
| 1978-08-01 | vs CIN | 105 | W 16-4 | 49-56 | 5 | 31,159 | Larry McWilliams | Fred Norman | Larry McWilliams | Pedro Borbon | Gene Garber | 401 | 481 | -80 |
| 1978-08-02 | vs CIN | 106 | L 2-6 | 49-57 | 5 | 26,812 | Preston Hanna | Tom Seaver | Tom Seaver | Preston Hanna | | 403 | 487 | -84 |
| 1978-08-04 | vs HOU | 107 | W 7-2 | 50-57 | 5 | 11,282 | Phil Niekro | Mark Lemongello | Phil Niekro | Mark Lemongello | | 410 | 489 | -79 |
| 1978-08-05 | vs HOU | 108 | L 3-5 | 50-59 | 6 | 0 | Preston Hanna | Joe Niekro | Joe Niekro | Preston Hanna | Ken Forsch | 413 | 494 | -81 |
| 1978-08-05 | vs HOU | 109 | L 0-7 | 50-59 | 6 | 20,950 | Tommy Boggs | Vern Ruhle | Vern Ruhle | Tommy Boggs | | 413 | 501 | -88 |
| 1978-08-06 | vs HOU | 110 | W 3-2 | 51-59 | 5 | 8,551 | Larry McWilliams | J.R. Richard | Larry McWilliams | J.R. Richard | Gene Garber | 416 | 503 | -87 |
| 1978-08-07 | @ CIN | 111 | W 5-3 | 52-59 | 5 | 33,215 | Mickey Mahler | Tom Seaver | Mickey Mahler | Tom Seaver | Gene Garber | 421 | 506 | -85 |
| 1978-08-08 | @ CIN | 112 | W 6-5 | 53-59 | 5 | 32,730 | Phil Niekro | Tom Hume | Phil Niekro | Tom Hume | | 427 | 511 | -84 |
| 1978-08-09 | @ CIN | 113 | L 0-10 | 53-60 | 5 | 34,090 | Tommy Boggs | Paul Moskau | Paul Moskau | Tommy Boggs | | 427 | 521 | -94 |
| 1978-08-11 | @ HOU | 114 | W 1-0 | 54-60 | 5 | 16,035 | Larry McWilliams | Joe Niekro | Larry McWilliams | Joe Niekro | Gene Garber | 428 | 521 | -93 |
| 1978-08-12 | @ HOU | 115 | L 2-5 | 54-61 | 5 | 25,023 | Phil Niekro | J.R. Richard | J.R. Richard | Phil Niekro | | 430 | 526 | -96 |
| 1978-08-13 | @ HOU | 116 | L 0-3 | 54-62 | 6 | 15,878 | Preston Hanna | Vern Ruhle | Vern Ruhle | Preston Hanna | | 430 | 529 | -99 |
| 1978-08-14 | @ CHN | 117 | L 7-13 | 54-63 | 6 | 27,130 | Mickey Mahler | Dave Roberts | Lynn McGlothen | Mickey Mahler | | 437 | 542 | -105 |
| 1978-08-15 | @ CHN | 118 | L 8-12 | 54-64 | 6 | 18,497 | Larry McWilliams | Dennis Lamp | Donnie Moore | Rick Camp | | 445 | 554 | -109 |
| 1978-08-16 | @ CHN | 119 | W 9-0 | 55-64 | 6 | 19,828 | Phil Niekro | Mike Krukow | Phil Niekro | Mike Krukow | | 454 | 554 | -100 |
| 1978-08-17 | @ SLN | 120 | L 3-4 | 55-65 | 6 | 10,543 | Mickey Mahler | John Denny | John Denny | Mickey Mahler | Mark Littell | 457 | 558 | -101 |
| 1978-08-18 | @ SLN | 121 | L 1-5 | 55-66 | 6 | 12,764 | Preston Hanna | Pete Vuckovich | Pete Vuckovich | Preston Hanna | | 458 | 563 | -105 |
| 1978-08-19 | @ SLN | 122 | W 3-0 | 56-66 | 5 | 24,313 | Larry McWilliams | Bob Forsch | Larry McWilliams | Bob Forsch | | 461 | 563 | -102 |
| 1978-08-20 | @ SLN | 123 | L 4-6 | 56-67 | 5 | 35,531 | Phil Niekro | Aurelio Lopez | Tom Bruno | Phil Niekro | | 465 | 569 | -104 |
| 1978-08-22 | vs PIT | 124 | L 1-3 | 56-68 | 6 | 9,348 | Mickey Mahler | Don Robinson | Don Robinson | Mickey Mahler | Kent Tekulve | 466 | 572 | -106 |
| 1978-08-23 | vs PIT | 125 | L 3-4 | 56-69 | 6 | 6,553 | Eddie Solomon | John Candelaria | Grant Jackson | Dave Campbell | | 469 | 576 | -107 |
| 1978-08-24 | vs PIT | 126 | L 1-5 | 56-70 | 6 | 7,965 | Phil Niekro | Bert Blyleven | Bert Blyleven | Phil Niekro | Kent Tekulve | 470 | 581 | -111 |
| 1978-08-25 | vs SLN | 127 | L 10-11 | 56-71 | 6 | 5,908 | Larry McWilliams | Bob Forsch | Tom Bruno | Gene Garber | Mark Littell | 480 | 592 | -112 |
| 1978-08-26 | vs SLN | 128 | L 4-9 | 56-72 | 6 | 18,024 | Preston Hanna | Silvio Martinez | Silvio Martinez | Preston Hanna | | 484 | 601 | -117 |
| 1978-08-27 | vs SLN | 129 | L 3-14 | 56-73 | 6 | 9,309 | Mickey Mahler | John Denny | John Denny | Mickey Mahler | | 487 | 615 | -128 |
| 1978-08-28 | vs CHN | 130 | W 4-3 | 57-73 | 6 | 4,007 | Phil Niekro | Dennis Lamp | Phil Niekro | Donnie Moore | Gene Garber | 491 | 618 | -127 |
| 1978-08-29 | vs CHN | 131 | W 4-3 | 58-73 | 6 | 3,244 | Eddie Solomon | Rick Reuschel | Eddie Solomon | Lynn McGlothen | Gene Garber | 495 | 621 | -126 |
| 1978-08-30 | vs CHN | 132 | W 6-2 | 59-73 | 6 | 3,305 | Larry McWilliams | Ray Burris | Larry McWilliams | Ray Burris | | 501 | 623 | -122 |
| 1978-09-01 | @ PIT | 133 | L 3-8 | 59-75 | 6 | 0 | Phil Niekro | Don Robinson | Don Robinson | Phil Niekro | Kent Tekulve | 504 | 631 | -127 |
| 1978-09-01 | @ PIT | 134 | L 0-3 | 59-75 | 6 | 14,306 | Mickey Mahler | Bruce Kison | Bruce Kison | Mickey Mahler | Kent Tekulve | 504 | 634 | -130 |
| 1978-09-02 | @ PIT | 135 | L 3-4 | 59-76 | 6 | 9,580 | Preston Hanna | John Candelaria | Grant Jackson | Rick Camp | | 507 | 638 | -131 |
| 1978-09-03 | @ PIT | 136 | L 3-6 | 59-77 | 6 | 8,594 | Eddie Solomon | Bert Blyleven | Kent Tekulve | Gene Garber | | 510 | 644 | -134 |
| 1978-09-04 | vs SDN | 137 | L 4-8 | 59-78 | 6 | 3,079 | Larry McWilliams | Gaylord Perry | Gaylord Perry | Larry McWilliams | John D'Acquisto | 514 | 652 | -138 |
| 1978-09-05 | vs SDN | 138 | W 8-1 | 60-78 | 6 | 1,192 | Phil Niekro | Eric Rasmussen | Phil Niekro | Eric Rasmussen | | 522 | 653 | -131 |
| 1978-09-06 | vs SDN | 139 | L 3-5 | 60-79 | 6 | 1,519 | Mickey Mahler | Randy Jones | Mark Lee | Gene Garber | Rollie Fingers | 525 | 658 | -133 |
| 1978-09-07 | vs SFN | 140 | W 6-5 | 61-79 | 6 | 3,460 | Preston Hanna | Vida Blue | Craig Skok | John Curtis | Gene Garber | 531 | 663 | -132 |
| 1978-09-08 | vs SFN | 141 | L 5-8 | 61-80 | 6 | 6,063 | Eddie Solomon | John Montefusco | John Montefusco | Eddie Solomon | Jim Barr | 536 | 671 | -135 |
| 1978-09-09 | vs LAN | 142 | W 7-4 | 62-80 | 6 | 26,777 | Phil Niekro | Tommy John | Phil Niekro | Rick Rhoden | Gene Garber | 543 | 675 | -132 |
| 1978-09-10 | vs LAN | 143 | L 5-11 | 62-81 | 6 | 11,108 | Jim Bouton | Don Sutton | Don Sutton | Jim Bouton | | 548 | 686 | -138 |
| 1978-09-11 | @ SDN | 144 | W 7-2 | 63-81 | 6 | 9,727 | Larry McWilliams | Randy Jones | Larry McWilliams | Randy Jones | | 555 | 688 | -133 |
| 1978-09-12 | @ SDN | 145 | L 1-3 | 63-82 | 6 | 11,222 | Mickey Mahler | Gaylord Perry | Gaylord Perry | Mickey Mahler | | 556 | 691 | -135 |
| 1978-09-13 | @ SFN | 146 | W 5-3 | 64-82 | 6 | 3,357 | Phil Niekro | Bob Knepper | Gene Garber | John Curtis | | 561 | 694 | -133 |
| 1978-09-14 | @ SFN | 147 | W 4-1 | 65-82 | 6 | 3,358 | Jim Bouton | Ed Halicki | Jim Bouton | Ed Halicki | Gene Garber | 565 | 695 | -130 |
| 1978-09-15 | @ LAN | 148 | L 0-5 | 65-83 | 6 | 47,188 | Eddie Solomon | Don Sutton | Don Sutton | Eddie Solomon | | 565 | 700 | -135 |
| 1978-09-16 | @ LAN | 149 | L 0-2 | 65-84 | 6 | 35,834 | Larry McWilliams | Doug Rau | Doug Rau | Larry McWilliams | Terry Forster | 565 | 702 | -137 |
| 1978-09-17 | @ LAN | 150 | W 3-2 | 66-84 | 6 | 27,993 | Phil Niekro | Burt Hooton | Phil Niekro | Burt Hooton | Gene Garber | 568 | 704 | -136 |
| 1978-09-19 | @ HOU | 151 | W 3-2 | 67-84 | 6 | 5,710 | Jim Bouton | J.R. Richard | Gene Garber | Joaquin Andujar | | 571 | 706 | -135 |
| 1978-09-20 | @ HOU | 152 | W 3-2 | 68-84 | 6 | 3,950 | Frank LaCorte | Joe Niekro | Gene Garber | Joe Niekro | | 574 | 708 | -134 |
| 1978-09-21 | @ HOU | 153 | L 0-2 | 68-85 | 6 | 3,775 | Phil Niekro | Ken Forsch | Ken Forsch | Phil Niekro | | 574 | 710 | -136 |
| 1978-09-22 | vs CIN | 154 | L 4-6 | 68-86 | 6 | 7,621 | Mickey Mahler | Paul Moskau | Mario Soto | Craig Skok | | 578 | 716 | -138 |
| 1978-09-23 | vs CIN | 155 | W 8-1 | 69-86 | 6 | 12,784 | Larry McWilliams | Mike LaCoss | Larry McWilliams | Mike LaCoss | | 586 | 717 | -131 |
| 1978-09-24 | vs CIN | 156 | L 1-2 | 69-87 | 5 | 12,298 | Jim Bouton | Tom Hume | Tom Hume | Jim Bouton | | 587 | 719 | -132 |
| 1978-09-26 | vs HOU | 157 | L 0-2 | 69-88 | 6 | 3,089 | Phil Niekro | Joe Niekro | Joe Niekro | Phil Niekro | Ken Forsch | 587 | 721 | -134 |
| 1978-09-27 | vs HOU | 158 | L 0-4 | 69-89 | 6 | 2,710 | Frank LaCorte | Vern Ruhle | Vern Ruhle | Frank LaCorte | | 587 | 725 | -138 |
| 1978-09-28 | vs HOU | 159 | L 3-4 | 69-90 | 6 | 2,560 | Larry McWilliams | J.R. Richard | J.R. Richard | Larry McWilliams | Ken Forsch | 590 | 729 | -139 |
| 1978-09-29 | @ CIN | 160 | L 2-7 | 69-91 | 6 | 20,660 | Jim Bouton | Tom Hume | Tom Hume | Jim Bouton | | 592 | 736 | -144 |
| 1978-09-30 | @ CIN | 161 | L 0-4 | 69-92 | 6 | 21,054 | Phil Niekro | Fred Norman | Fred Norman | Phil Niekro | | 592 | 740 | -148 |
| 1978-10-01 | @ CIN | 162 | L 8-10 | 69-93 | 6 | 35,840 | Mickey Mahler | Tom Seaver | Dan Dumoulin | Dave Campbell | | 600 | 750 | -150 |