| 1978-04-07 | @ PHI | 1 | W 5-1 | 1-0 | 3 | 47,791 | Bob Forsch | Steve Carlton | Bob Forsch | Steve Carlton | | 5 | 1 | 4 |
| 1978-04-08 | @ PHI | 2 | L 0-7 | 1-1 | 4 | 24,441 | Eric Rasmussen | Larry Christenson | Larry Christenson | Eric Rasmussen | | 5 | 8 | -3 |
| 1978-04-09 | @ PHI | 3 | L 3-12 | 1-2 | 5 | 35,104 | John Urrea | Randy Lerch | Randy Lerch | John Urrea | | 8 | 20 | -12 |
| 1978-04-10 | vs PIT | 4 | W 11-2 | 2-2 | 4 | 19,241 | John Denny | Jim Rooker | John Denny | Jim Rooker | | 19 | 22 | -3 |
| 1978-04-12 | vs PIT | 5 | W 5-1 | 3-2 | 1 | 12,294 | Bob Forsch | John Candelaria | Bob Forsch | John Candelaria | | 24 | 23 | 1 |
| 1978-04-13 | vs PIT | 6 | W 6-5 | 4-2 | 1 | 12,351 | Eric Rasmussen | Bert Blyleven | Eric Rasmussen | Bert Blyleven | | 30 | 28 | 2 |
| 1978-04-14 | vs PHI | 7 | L 3-4 | 4-3 | 4 | 17,921 | Mark Littell | Steve Carlton | Steve Carlton | Pete Vuckovich | Tug McGraw | 33 | 32 | 1 |
| 1978-04-15 | vs PHI | 8 | L 2-3 | 4-4 | 4 | 13,844 | John Denny | Larry Christenson | Tug McGraw | Pete Vuckovich | | 35 | 35 | 0 |
| 1978-04-16 | vs PHI | 9 | W 5-0 | 5-4 | 3 | 11,495 | Bob Forsch | Randy Lerch | Bob Forsch | Randy Lerch | | 40 | 35 | 5 |
| 1978-04-17 | vs NYN | 10 | L 2-6 | 5-5 | 5 | 6,371 | Pete Falcone | Nino Espinosa | Nino Espinosa | Pete Falcone | Skip Lockwood | 42 | 41 | 1 |
| 1978-04-18 | vs NYN | 11 | L 2-3 | 5-6 | 4 | 5,728 | Eric Rasmussen | Mike Bruhert | Mike Bruhert | Eric Rasmussen | Skip Lockwood | 44 | 44 | 0 |
| 1978-04-19 | vs NYN | 12 | L 0-2 | 5-7 | 5 | 6,958 | Mark Littell | Pat Zachry | Pat Zachry | Mark Littell | | 44 | 46 | -2 |
| 1978-04-22 | @ PIT | 13 | L 7-8 | 5-8 | 5 | 5,173 | John Denny | Bert Blyleven | Kent Tekulve | John Urrea | | 51 | 54 | -3 |
| 1978-04-23 | @ PIT | 14 | L 7-14 | 5-10 | 6 | 0 | Bob Forsch | John Candelaria | Bruce Kison | Bob Forsch | | 58 | 68 | -10 |
| 1978-04-23 | @ PIT | 15 | L 4-5 | 5-10 | 6 | 10,008 | Pete Falcone | Jerry Reuss | Jim Bibby | Pete Vuckovich | Don Robinson | 62 | 73 | -11 |
| 1978-04-24 | @ MON | 16 | L 3-5 | 5-11 | 6 | 11,448 | Eric Rasmussen | Rudy May | Rudy May | Mark Littell | Stan Bahnsen | 65 | 78 | -13 |
| 1978-04-25 | @ MON | 17 | W 7-2 | 6-11 | 6 | 12,444 | John Urrea | Hal Dues | John Urrea | Hal Dues | | 72 | 80 | -8 |
| 1978-04-26 | @ MON | 18 | W 12-2 | 7-11 | 6 | 10,999 | John Denny | Wayne Twitchell | John Denny | Wayne Twitchell | | 84 | 82 | 2 |
| 1978-04-28 | vs LAN | 19 | L 1-7 | 7-12 | 6 | 23,823 | Bob Forsch | Rick Rhoden | Rick Rhoden | Bob Forsch | | 85 | 89 | -4 |
| 1978-04-29 | vs LAN | 20 | W 1-0 | 8-12 | 6 | 20,596 | Eric Rasmussen | Burt Hooton | Eric Rasmussen | Burt Hooton | | 86 | 89 | -3 |
| 1978-04-30 | vs LAN | 21 | W 4-0 | 9-12 | 6 | 21,677 | John Urrea | Don Sutton | John Urrea | Don Sutton | Pete Vuckovich | 90 | 89 | 1 |
| 1978-05-01 | vs SFN | 22 | L 1-2 | 9-13 | 6 | 9,085 | John Denny | Vida Blue | Vida Blue | John Denny | Randy Moffitt | 91 | 91 | 0 |
| 1978-05-02 | vs SFN | 23 | W 9-0 | 10-13 | 5 | 6,039 | Bob Forsch | John Montefusco | Bob Forsch | John Montefusco | | 100 | 91 | 9 |
| 1978-05-03 | vs SFN | 24 | L 0-4 | 10-14 | 6 | 6,583 | Eric Rasmussen | Jim Barr | Jim Barr | Eric Rasmussen | | 100 | 95 | 5 |
| 1978-05-05 | vs SDN | 25 | L 1-2 | 10-15 | 6 | 7,831 | John Urrea | Randy Jones | Randy Jones | John Urrea | Rollie Fingers | 101 | 97 | 4 |
| 1978-05-06 | vs SDN | 26 | W 1-0 | 11-15 | 5 | 13,534 | John Denny | Gaylord Perry | John Denny | Gaylord Perry | | 102 | 97 | 5 |
| 1978-05-07 | vs SDN | 27 | W 8-4 | 12-15 | 5 | 19,629 | Bob Forsch | Bob Owchinko | Bob Forsch | Dave Freisleben | | 110 | 101 | 9 |
| 1978-05-09 | @ LAN | 28 | L 1-3 | 12-16 | 5 | 33,262 | Eric Rasmussen | Doug Rau | Doug Rau | Eric Rasmussen | Terry Forster | 111 | 104 | 7 |
| 1978-05-10 | @ LAN | 29 | W 6-5 | 13-16 | 5 | 34,851 | John Denny | Rick Rhoden | Mark Littell | Rick Rhoden | | 117 | 109 | 8 |
| 1978-05-11 | @ LAN | 30 | W 2-0 | 14-16 | 5 | 30,007 | Bob Forsch | Burt Hooton | Bob Forsch | Burt Hooton | | 119 | 109 | 10 |
| 1978-05-12 | @ SFN | 31 | L 3-9 | 14-17 | 5 | 16,788 | John Urrea | Vida Blue | Vida Blue | John Urrea | | 122 | 118 | 4 |
| 1978-05-13 | @ SFN | 32 | L 6-7 | 14-18 | 5 | 12,367 | Eric Rasmussen | John Montefusco | John Montefusco | Mark Littell | Gary Lavelle | 128 | 125 | 3 |
| 1978-05-14 | @ SFN | 33 | L 4-5 | 14-20 | 6 | 0 | John Denny | Jim Barr | Gary Lavelle | Mark Littell | | 132 | 130 | 2 |
| 1978-05-14 | @ SFN | 34 | L 3-4 | 14-20 | 6 | 25,776 | Pete Falcone | Ed Halicki | Charlie Williams | Mark Littell | | 135 | 134 | 1 |
| 1978-05-15 | @ SDN | 35 | L 3-4 | 14-21 | 6 | 17,199 | Bob Forsch | Gaylord Perry | Mark Lee | Pete Vuckovich | | 138 | 138 | 0 |
| 1978-05-16 | @ SDN | 36 | L 5-7 | 14-22 | 6 | 14,434 | John Urrea | Bob Owchinko | Bob Owchinko | John Urrea | John D'Acquisto | 143 | 145 | -2 |
| 1978-05-17 | @ SDN | 37 | L 2-5 | 14-23 | 6 | 13,732 | Eric Rasmussen | Bob Shirley | Bob Shirley | Eric Rasmussen | Rollie Fingers | 145 | 150 | -5 |
| 1978-05-19 | @ CHN | 38 | L 2-6 | 14-24 | 6 | 15,389 | John Denny | Dave Roberts | Dave Roberts | John Denny | | 147 | 156 | -9 |
| 1978-05-20 | @ CHN | 39 | L 2-10 | 14-25 | 6 | 27,300 | Pete Falcone | Dennis Lamp | Woodie Fryman | Pete Falcone | Donnie Moore | 149 | 166 | -17 |
| 1978-05-21 | @ CHN | 40 | L 2-3 | 14-26 | 6 | 31,557 | Eric Rasmussen | Rick Reuschel | Rick Reuschel | Mark Littell | Bruce Sutter | 151 | 169 | -18 |
| 1978-05-23 | vs MON | 41 | L 1-4 | 14-27 | 6 | 11,128 | Bob Forsch | Rudy May | Rudy May | Bob Forsch | Mike Garman | 152 | 173 | -21 |
| 1978-05-24 | vs MON | 42 | W 2-0 | 15-27 | 6 | 12,135 | John Denny | Hal Dues | John Denny | Hal Dues | | 154 | 173 | -19 |
| 1978-05-25 | vs MON | 43 | L 2-11 | 15-28 | 6 | 8,948 | John Urrea | Ross Grimsley | Ross Grimsley | John Urrea | | 156 | 184 | -28 |
| 1978-05-26 | vs CHN | 44 | L 0-6 | 15-29 | 6 | 20,068 | Pete Falcone | Dave Roberts | Dave Roberts | Pete Falcone | | 156 | 190 | -34 |
| 1978-05-27 | vs CHN | 45 | L 2-3 | 15-30 | 6 | 33,333 | Bob Forsch | Dennis Lamp | Guillermo Hernandez | Buddy Schultz | | 158 | 193 | -35 |
| 1978-05-28 | vs CHN | 46 | L 0-2 | 15-31 | 6 | 29,704 | John Denny | Ray Burris | Ray Burris | John Denny | | 158 | 195 | -37 |
| 1978-05-29 | @ NYN | 47 | L 2-7 | 16-32 | 6 | 0 | John Urrea | Pat Zachry | Pat Zachry | John Urrea | | 160 | 202 | -42 |
| 1978-05-29 | @ NYN | 48 | W 6-2 | 16-32 | 6 | 28,896 | Pete Falcone | Craig Swan | Pete Vuckovich | Craig Swan | | 166 | 204 | -38 |
| 1978-05-30 | @ NYN | 49 | W 8-2 | 17-32 | 6 | 13,412 | Silvio Martinez | Jerry Koosman | Silvio Martinez | Jerry Koosman | | 174 | 206 | -32 |
| 1978-05-31 | @ NYN | 50 | W 5-4 | 18-32 | 6 | 3,933 | Bob Forsch | Mike Bruhert | Bob Forsch | Mike Bruhert | Buddy Schultz | 179 | 210 | -31 |
| 1978-06-02 | @ HOU | 51 | L 1-2 | 18-33 | 6 | 10,315 | John Denny | Joaquin Andujar | Joe Sambito | John Denny | | 180 | 212 | -32 |
| 1978-06-03 | @ HOU | 52 | L 2-5 | 19-34 | 6 | 0 | Pete Falcone | Floyd Bannister | Floyd Bannister | Pete Falcone | Ken Forsch | 182 | 217 | -35 |
| 1978-06-03 | @ HOU | 53 | W 2-1 | 19-34 | 6 | 27,822 | Pete Vuckovich | Tom Dixon | Pete Vuckovich | Tom Dixon | | 184 | 218 | -34 |
| 1978-06-04 | @ HOU | 54 | W 4-2 | 20-34 | 6 | 10,238 | Silvio Martinez | J.R. Richard | Silvio Martinez | J.R. Richard | Buddy Schultz | 188 | 220 | -32 |
| 1978-06-05 | vs CIN | 55 | L 1-2 | 20-35 | 6 | 32,057 | Bob Forsch | Tom Seaver | Tom Seaver | Bob Forsch | | 189 | 222 | -33 |
| 1978-06-06 | vs CIN | 56 | W 4-1 | 21-35 | 6 | 17,274 | John Denny | Tom Hume | John Denny | Tom Hume | | 193 | 223 | -30 |
| 1978-06-07 | vs ATL | 57 | L 0-6 | 21-36 | 6 | 10,756 | Pete Falcone | Phil Niekro | Phil Niekro | Pete Falcone | | 193 | 229 | -36 |
| 1978-06-08 | vs ATL | 58 | W 2-0 | 22-36 | 6 | 11,576 | Pete Vuckovich | Preston Hanna | Pete Vuckovich | Preston Hanna | Mark Littell | 195 | 229 | -34 |
| 1978-06-09 | vs HOU | 59 | L 7-11 | 22-37 | 6 | 40,764 | Silvio Martinez | J.R. Richard | J.R. Richard | George Frazier | Ken Forsch | 202 | 240 | -38 |
| 1978-06-10 | vs HOU | 60 | L 5-12 | 22-38 | 6 | 18,485 | Bob Forsch | Mark Lemongello | Mark Lemongello | Bob Forsch | | 207 | 252 | -45 |
| 1978-06-11 | vs HOU | 61 | W 5-3 | 23-38 | 6 | 17,298 | John Denny | Joaquin Andujar | John Denny | Joaquin Andujar | | 212 | 255 | -43 |
| 1978-06-12 | @ ATL | 62 | L 1-2 | 23-39 | 6 | 7,970 | Pete Vuckovich | Mickey Mahler | Mickey Mahler | Pete Vuckovich | | 213 | 257 | -44 |
| 1978-06-13 | @ ATL | 63 | L 1-12 | 23-40 | 6 | 7,384 | Silvio Martinez | Preston Hanna | Preston Hanna | Silvio Martinez | | 214 | 269 | -55 |
| 1978-06-14 | @ ATL | 64 | L 1-7 | 23-41 | 6 | 6,463 | Bob Forsch | Adrian Devine | Adrian Devine | Bob Forsch | | 215 | 276 | -61 |
| 1978-06-16 | @ CIN | 65 | L 0-4 | 23-42 | 6 | 38,216 | John Denny | Tom Seaver | Tom Seaver | John Denny | | 215 | 280 | -65 |
| 1978-06-17 | @ CIN | 66 | L 5-6 | 23-43 | 6 | 40,262 | Pete Vuckovich | Bill Bonham | Pedro Borbon | Buddy Schultz | | 220 | 286 | -66 |
| 1978-06-18 | @ CIN | 67 | L 2-4 | 23-44 | 6 | 40,016 | Silvio Martinez | Fred Norman | Fred Norman | Silvio Martinez | Manny Sarmiento | 222 | 290 | -68 |
| 1978-06-20 | @ PHI | 68 | W 4-2 | 24-44 | 6 | 30,119 | Bob Forsch | Larry Christenson | Bob Forsch | Larry Christenson | Mark Littell | 226 | 292 | -66 |
| 1978-06-22 | @ PHI | 69 | L 1-2 | 24-45 | 6 | 29,183 | John Denny | Steve Carlton | Steve Carlton | John Denny | | 227 | 294 | -67 |
| 1978-06-23 | vs MON | 70 | W 8-4 | 25-45 | 6 | 13,732 | Pete Vuckovich | Rudy May | Pete Vuckovich | Rudy May | Mark Littell | 235 | 298 | -63 |
| 1978-06-24 | vs MON | 71 | L 0-2 | 25-46 | 6 | 19,122 | Silvio Martinez | Woodie Fryman | Woodie Fryman | Silvio Martinez | Mike Garman | 235 | 300 | -65 |
| 1978-06-25 | vs MON | 72 | W 7-5 | 26-46 | 6 | 22,671 | Bob Forsch | Ross Grimsley | Buddy Schultz | Rudy May | | 242 | 305 | -63 |
| 1978-06-26 | @ PIT | 73 | L 8-11 | 26-47 | 6 | 5,045 | John Denny | Jim Rooker | Ed Whitson | John Urrea | Kent Tekulve | 250 | 316 | -66 |
| 1978-06-27 | @ PIT | 74 | W 2-0 | 28-47 | 6 | 0 | Pete Vuckovich | John Candelaria | Pete Vuckovich | John Candelaria | Buddy Schultz | 252 | 316 | -64 |
| 1978-06-27 | @ PIT | 75 | W 6-1 | 28-47 | 6 | 9,229 | Pete Falcone | Jerry Reuss | Pete Falcone | Jerry Reuss | | 258 | 317 | -59 |
| 1978-06-28 | @ PIT | 76 | W 7-5 | 29-47 | 6 | 7,742 | Silvio Martinez | Jim Bibby | Roy Thomas | Kent Tekulve | | 265 | 322 | -57 |
| 1978-06-30 | @ MON | 77 | W 2-1 | 30-47 | 6 | 22,829 | Bob Forsch | Ross Grimsley | Bob Forsch | Ross Grimsley | Roy Thomas | 267 | 323 | -56 |
| 1978-07-01 | @ MON | 78 | L 2-3 | 30-48 | 6 | 17,906 | John Denny | Steve Rogers | Steve Rogers | Mark Littell | | 269 | 326 | -57 |
| 1978-07-02 | @ MON | 79 | W 5-4 | 32-48 | 6 | 0 | Pete Vuckovich | Woodie Fryman | Pete Vuckovich | Woodie Fryman | Buddy Schultz | 274 | 330 | -56 |
| 1978-07-02 | @ MON | 80 | W 4-2 | 32-48 | 6 | 37,685 | John Urrea | Rudy May | John Urrea | Rudy May | Roy Thomas | 278 | 332 | -54 |
| 1978-07-03 | vs CHN | 81 | L 2-6 | 32-49 | 6 | 31,719 | Pete Falcone | Dave Roberts | Dave Roberts | Pete Falcone | Bruce Sutter | 280 | 338 | -58 |
| 1978-07-04 | vs CHN | 82 | L 5-7 | 32-50 | 6 | 21,351 | Silvio Martinez | Ray Burris | Dave Geisel | George Frazier | Bruce Sutter | 285 | 345 | -60 |
| 1978-07-05 | vs CHN | 83 | L 1-5 | 32-51 | 6 | 19,683 | Bob Forsch | Mike Krukow | Mike Krukow | Bob Forsch | Bruce Sutter | 286 | 350 | -64 |
| 1978-07-06 | vs PIT | 84 | W 3-2 | 33-51 | 6 | 14,832 | John Denny | Jim Rooker | John Denny | Jim Rooker | | 289 | 352 | -63 |
| 1978-07-07 | vs PIT | 85 | L 1-2 | 33-52 | 6 | 13,813 | Pete Vuckovich | John Candelaria | John Candelaria | Pete Vuckovich | Kent Tekulve | 290 | 354 | -64 |
| 1978-07-08 | vs PIT | 86 | W 4-0 | 34-52 | 6 | 20,524 | Silvio Martinez | Don Robinson | Silvio Martinez | Don Robinson | | 294 | 354 | -60 |
| 1978-07-09 | vs PIT | 87 | L 1-6 | 34-53 | 6 | 22,101 | Bob Forsch | Bert Blyleven | Bert Blyleven | Bob Forsch | Kent Tekulve | 295 | 360 | -65 |
| 1978-07-13 | vs LAN | 88 | W 6-1 | 35-53 | 6 | 16,819 | John Denny | Tommy John | John Denny | Tommy John | | 301 | 361 | -60 |
| 1978-07-14 | vs LAN | 89 | W 4-1 | 36-53 | 6 | 23,694 | Pete Vuckovich | Don Sutton | Pete Vuckovich | Don Sutton | | 305 | 362 | -57 |
| 1978-07-15 | vs LAN | 90 | L 1-2 | 36-54 | 6 | 33,903 | Bob Forsch | Doug Rau | Doug Rau | Bob Forsch | Terry Forster | 306 | 364 | -58 |
| 1978-07-16 | vs SFN | 91 | W 9-4 | 37-55 | 6 | 0 | Silvio Martinez | Jim Barr | Silvio Martinez | Jim Barr | Buddy Schultz | 315 | 368 | -53 |
| 1978-07-16 | vs SFN | 92 | L 0-6 | 37-55 | 6 | 31,771 | John Urrea | Ed Halicki | Ed Halicki | John Urrea | | 315 | 374 | -59 |
| 1978-07-17 | vs SFN | 93 | L 7-9 | 37-56 | 6 | 16,651 | John Denny | Bob Knepper | Gary Lavelle | Buddy Schultz | | 322 | 383 | -61 |
| 1978-07-18 | vs SDN | 94 | L 2-3 | 37-57 | 6 | 13,271 | Pete Vuckovich | Eric Rasmussen | Eric Rasmussen | Pete Vuckovich | | 324 | 386 | -62 |
| 1978-07-19 | vs SDN | 95 | L 3-5 | 37-58 | 6 | 11,053 | Roy Thomas | Randy Jones | Randy Jones | Roy Thomas | Bob Shirley | 327 | 391 | -64 |
| 1978-07-20 | vs SDN | 96 | W 3-2 | 38-58 | 6 | 8,510 | Bob Forsch | Bob Owchinko | Buddy Schultz | Rollie Fingers | Mark Littell | 330 | 393 | -63 |
| 1978-07-21 | @ LAN | 97 | L 5-7 | 38-59 | 6 | 51,911 | Silvio Martinez | Burt Hooton | Burt Hooton | Silvio Martinez | Terry Forster | 335 | 400 | -65 |
| 1978-07-22 | @ LAN | 98 | L 3-4 | 38-60 | 6 | 42,165 | John Denny | Tommy John | Tommy John | John Denny | Terry Forster | 338 | 404 | -66 |
| 1978-07-23 | @ LAN | 99 | W 2-0 | 39-60 | 6 | 48,184 | Pete Vuckovich | Don Sutton | Pete Vuckovich | Don Sutton | | 340 | 404 | -64 |
| 1978-07-25 | @ SFN | 100 | L 2-3 | 39-61 | 6 | 39,289 | Bob Forsch | Vida Blue | Vida Blue | Bob Forsch | | 342 | 407 | -65 |
| 1978-07-26 | @ SFN | 101 | W 2-1 | 40-61 | 6 | 18,769 | Silvio Martinez | Ed Halicki | Silvio Martinez | Ed Halicki | | 344 | 408 | -64 |
| 1978-07-28 | @ SDN | 102 | L 3-8 | 40-62 | 6 | 17,217 | John Denny | Randy Jones | Randy Jones | John Denny | | 347 | 416 | -69 |
| 1978-07-29 | @ SDN | 103 | L 3-7 | 40-63 | 6 | 18,696 | Pete Vuckovich | Bob Owchinko | Bob Owchinko | Pete Vuckovich | | 350 | 423 | -73 |
| 1978-07-30 | @ SDN | 104 | L 2-3 | 40-64 | 6 | 16,478 | Bob Forsch | Gaylord Perry | Gaylord Perry | Bob Forsch | Rollie Fingers | 352 | 426 | -74 |
| 1978-08-01 | @ CHN | 105 | L 2-4 | 40-65 | 6 | 22,242 | Silvio Martinez | Dennis Lamp | Dennis Lamp | Silvio Martinez | Bruce Sutter | 354 | 430 | -76 |
| 1978-08-02 | @ CHN | 106 | L 2-3 | 40-66 | 6 | 14,610 | Aurelio Lopez | Mike Krukow | Mike Krukow | Aurelio Lopez | Bruce Sutter | 356 | 433 | -77 |
| 1978-08-03 | @ CHN | 107 | L 2-3 | 40-67 | 6 | 21,596 | Pete Vuckovich | Ken Holtzman | Donnie Moore | Pete Vuckovich | | 358 | 436 | -78 |
| 1978-08-04 | vs NYN | 108 | L 3-8 | 40-68 | 6 | 15,153 | Bob Forsch | Craig Swan | Craig Swan | Bob Forsch | | 361 | 444 | -83 |
| 1978-08-05 | vs NYN | 109 | W 5-3 | 41-68 | 6 | 19,689 | Pete Falcone | Nino Espinosa | Tom Bruno | Nino Espinosa | Mark Littell | 366 | 447 | -81 |
| 1978-08-06 | vs NYN | 110 | W 3-1 | 42-68 | 6 | 17,198 | Silvio Martinez | Jerry Koosman | Silvio Martinez | Jerry Koosman | Roy Thomas | 369 | 448 | -79 |
| 1978-08-07 | vs PHI | 111 | W 6-3 | 43-68 | 6 | 18,671 | Aurelio Lopez | Randy Lerch | Aurelio Lopez | Randy Lerch | Mark Littell | 375 | 451 | -76 |
| 1978-08-08 | vs PHI | 112 | W 2-0 | 45-68 | 6 | 0 | Pete Vuckovich | Larry Christenson | Pete Vuckovich | Larry Christenson | | 377 | 451 | -74 |
| 1978-08-08 | vs PHI | 113 | W 6-2 | 45-68 | 6 | 26,880 | Tom Bruno | Jim Lonborg | Tom Bruno | Jim Lonborg | | 383 | 453 | -70 |
| 1978-08-09 | vs PHI | 114 | L 3-6 | 45-69 | 6 | 16,172 | Bob Forsch | Jim Kaat | Jim Kaat | Bob Forsch | Ron Reed | 386 | 459 | -73 |
| 1978-08-11 | @ NYN | 115 | W 4-1 | 46-69 | 6 | 10,434 | Silvio Martinez | Jerry Koosman | Aurelio Lopez | Dale Murray | Tom Bruno | 390 | 460 | -70 |
| 1978-08-12 | @ NYN | 116 | W 5-1 | 47-69 | 6 | 8,623 | John Denny | Kevin Kobel | John Denny | Kevin Kobel | | 395 | 461 | -66 |
| 1978-08-13 | @ NYN | 117 | W 6-1 | 48-69 | 6 | 11,088 | Pete Vuckovich | Mike Bruhert | Pete Vuckovich | Mike Bruhert | | 401 | 462 | -61 |
| 1978-08-14 | vs HOU | 118 | L 0-6 | 48-70 | 6 | 12,555 | Bob Forsch | Tom Dixon | Tom Dixon | Bob Forsch | | 401 | 468 | -67 |
| 1978-08-15 | vs HOU | 119 | W 11-5 | 49-70 | 6 | 12,606 | Aurelio Lopez | Floyd Bannister | Aurelio Lopez | Floyd Bannister | | 412 | 473 | -61 |
| 1978-08-16 | vs HOU | 120 | L 2-4 | 49-71 | 6 | 10,829 | Silvio Martinez | Joe Niekro | Joe Niekro | Silvio Martinez | | 414 | 477 | -63 |
| 1978-08-17 | vs ATL | 121 | W 4-3 | 50-71 | 5 | 10,543 | John Denny | Mickey Mahler | John Denny | Mickey Mahler | Mark Littell | 418 | 480 | -62 |
| 1978-08-18 | vs ATL | 122 | W 5-1 | 51-71 | 5 | 12,764 | Pete Vuckovich | Preston Hanna | Pete Vuckovich | Preston Hanna | | 423 | 481 | -58 |
| 1978-08-19 | vs ATL | 123 | L 0-3 | 51-72 | 5 | 24,313 | Bob Forsch | Larry McWilliams | Larry McWilliams | Bob Forsch | | 423 | 484 | -61 |
| 1978-08-20 | vs ATL | 124 | W 6-4 | 52-72 | 5 | 35,531 | Aurelio Lopez | Phil Niekro | Tom Bruno | Phil Niekro | | 429 | 488 | -59 |
| 1978-08-21 | @ CIN | 125 | W 14-9 | 53-72 | 5 | 30,548 | Silvio Martinez | Bill Bonham | Silvio Martinez | Bill Bonham | | 443 | 497 | -54 |
| 1978-08-22 | @ CIN | 126 | L 4-5 | 53-73 | 5 | 31,182 | John Denny | Tom Seaver | Dave Tomlin | Tom Bruno | | 447 | 502 | -55 |
| 1978-08-24 | @ CIN | 127 | W 4-3 | 54-73 | 5 | 30,054 | Pete Vuckovich | Paul Moskau | Pete Vuckovich | Paul Moskau | | 451 | 505 | -54 |
| 1978-08-25 | @ ATL | 128 | W 11-10 | 55-73 | 5 | 5,908 | Bob Forsch | Larry McWilliams | Tom Bruno | Gene Garber | Mark Littell | 462 | 515 | -53 |
| 1978-08-26 | @ ATL | 129 | W 9-4 | 56-73 | 5 | 18,024 | Silvio Martinez | Preston Hanna | Silvio Martinez | Preston Hanna | | 471 | 519 | -48 |
| 1978-08-27 | @ ATL | 130 | W 14-3 | 57-73 | 5 | 9,309 | John Denny | Mickey Mahler | John Denny | Mickey Mahler | | 485 | 522 | -37 |
| 1978-08-29 | @ HOU | 131 | L 3-6 | 57-74 | 5 | 6,692 | Pete Vuckovich | Ken Forsch | Ken Forsch | Pete Vuckovich | | 488 | 528 | -40 |
| 1978-08-30 | @ HOU | 132 | W 4-2 | 58-74 | 5 | 6,480 | Bob Forsch | Joe Niekro | Bob Forsch | Joe Niekro | | 492 | 530 | -38 |
| 1978-08-31 | vs CIN | 133 | L 6-11 | 58-75 | 5 | 16,112 | Silvio Martinez | Tom Seaver | Tom Seaver | Silvio Martinez | | 498 | 541 | -43 |
| 1978-09-01 | vs CIN | 134 | L 2-5 | 58-76 | 5 | 17,257 | John Denny | Paul Moskau | Paul Moskau | John Denny | Doug Bair | 500 | 546 | -46 |
| 1978-09-02 | vs CIN | 135 | L 3-6 | 58-77 | 5 | 20,336 | Pete Vuckovich | Fred Norman | Pedro Borbon | Mark Littell | Doug Bair | 503 | 552 | -49 |
| 1978-09-03 | vs CIN | 136 | W 10-2 | 59-77 | 5 | 22,051 | Pete Falcone | Mike LaCoss | Pete Falcone | Mike LaCoss | | 513 | 554 | -41 |
| 1978-09-04 | vs PHI | 137 | W 3-2 | 60-78 | 5 | 0 | Bob Forsch | Randy Lerch | Bob Forsch | Randy Lerch | Mark Littell | 516 | 556 | -40 |
| 1978-09-04 | vs PHI | 138 | L 2-10 | 60-78 | 5 | 19,015 | Silvio Martinez | Jim Lonborg | Jim Lonborg | Silvio Martinez | | 518 | 566 | -48 |
| 1978-09-06 | vs PIT | 139 | L 1-4 | 60-79 | 5 | 7,945 | John Denny | Don Robinson | Don Robinson | John Denny | | 519 | 570 | -51 |
| 1978-09-07 | vs PIT | 140 | W 5-4 | 61-79 | 5 | 7,805 | Pete Falcone | Bruce Kison | Aurelio Lopez | Grant Jackson | Mark Littell | 524 | 574 | -50 |
| 1978-09-08 | @ PHI | 141 | L 0-1 | 61-81 | 5 | 0 | Tom Bruno | Dick Ruthven | Dick Ruthven | Tom Bruno | | 524 | 575 | -51 |
| 1978-09-08 | @ PHI | 142 | L 1-2 | 61-81 | 5 | 35,160 | Dan O'Brien | Jim Kaat | Ron Reed | Dan O'Brien | | 525 | 577 | -52 |
| 1978-09-09 | @ PHI | 143 | L 3-6 | 61-82 | 5 | 35,824 | Bob Forsch | Randy Lerch | Randy Lerch | Bob Forsch | | 528 | 583 | -55 |
| 1978-09-10 | @ PHI | 144 | W 8-6 | 62-82 | 5 | 33,106 | Silvio Martinez | Jim Lonborg | Mark Littell | Ron Reed | Buddy Schultz | 536 | 589 | -53 |
| 1978-09-11 | @ MON | 145 | L 1-3 | 62-83 | 5 | 4,949 | John Denny | Ross Grimsley | Ross Grimsley | John Denny | | 537 | 592 | -55 |
| 1978-09-12 | @ MON | 146 | L 1-5 | 62-84 | 5 | 8,672 | Pete Vuckovich | Rudy May | Rudy May | Pete Vuckovich | | 538 | 597 | -59 |
| 1978-09-13 | @ PIT | 147 | L 1-7 | 62-85 | 5 | 6,398 | Pete Falcone | Bert Blyleven | Bert Blyleven | Pete Falcone | | 539 | 604 | -65 |
| 1978-09-14 | @ PIT | 148 | L 4-7 | 62-86 | 5 | 5,294 | Bob Forsch | Jim Rooker | Jim Rooker | Bob Forsch | | 543 | 611 | -68 |
| 1978-09-15 | @ CHN | 149 | W 6-2 | 63-86 | 5 | 5,097 | Rob Dressler | Mike Krukow | Mark Littell | Bruce Sutter | | 549 | 613 | -64 |
| 1978-09-16 | @ CHN | 150 | W 4-1 | 64-86 | 5 | 18,738 | John Denny | Dennis Lamp | John Denny | Dennis Lamp | Mark Littell | 553 | 614 | -61 |
| 1978-09-17 | @ CHN | 151 | L 2-4 | 64-87 | 5 | 18,340 | Pete Vuckovich | Ray Burris | Ray Burris | Pete Vuckovich | | 555 | 618 | -63 |
| 1978-09-19 | vs NYN | 152 | W 5-3 | 65-87 | 5 | 5,257 | Tom Bruno | Nino Espinosa | Mark Littell | Dale Murray | | 560 | 621 | -61 |
| 1978-09-20 | vs NYN | 153 | L 6-7 | 65-88 | 5 | 6,030 | Dan O'Brien | Kevin Kobel | Kevin Kobel | George Frazier | Jerry Koosman | 566 | 628 | -62 |
| 1978-09-21 | vs NYN | 154 | W 6-2 | 66-88 | 5 | 3,912 | John Urrea | Craig Swan | John Urrea | Craig Swan | | 572 | 630 | -58 |
| 1978-09-22 | vs CHN | 155 | L 3-5 | 66-89 | 5 | 15,062 | Bob Forsch | Ray Burris | Ray Burris | Aurelio Lopez | Dave Roberts | 575 | 635 | -60 |
| 1978-09-23 | vs CHN | 156 | W 5-1 | 67-89 | 5 | 16,790 | John Denny | Rick Reuschel | John Denny | Rick Reuschel | | 580 | 636 | -56 |
| 1978-09-24 | vs CHN | 157 | L 4-5 | 67-90 | 5 | 17,033 | Pete Vuckovich | Ken Holtzman | Lynn McGlothen | Tom Bruno | Bruce Sutter | 584 | 641 | -57 |
| 1978-09-25 | @ NYN | 158 | W 3-0 | 68-90 | 5 | 3,697 | Silvio Martinez | Kevin Kobel | Silvio Martinez | Kevin Kobel | | 587 | 641 | -54 |
| 1978-09-26 | @ NYN | 159 | L 1-3 | 68-91 | 5 | 3,698 | Rob Dressler | Craig Swan | Craig Swan | Rob Dressler | Dale Murray | 588 | 644 | -56 |
| 1978-09-29 | vs MON | 160 | L 5-7 | 68-92 | 5 | 6,280 | John Urrea | Scott Sanderson | Darold Knowles | Buddy Schultz | Woodie Fryman | 593 | 651 | -58 |
| 1978-09-30 | vs MON | 161 | W 6-1 | 69-92 | 5 | 4,504 | John Denny | Dan Schatzeder | John Denny | Dan Schatzeder | | 599 | 652 | -53 |
| 1978-10-01 | vs MON | 162 | L 1-5 | 69-93 | 5 | 6,182 | Pete Vuckovich | Ross Grimsley | Ross Grimsley | Dan O'Brien | | 600 | 657 | -57 |