| 1978-04-07 | @ SFN | 1 | W 3-2 | 1-0 | 3 | 36,131 | Gaylord Perry | John Montefusco | Mickey Lolich | Gary Lavelle | Rollie Fingers | 3 | 2 | 1 |
| 1978-04-08 | @ SFN | 2 | L 0-6 | 1-1 | 3 | 10,726 | Bob Shirley | Jim Barr | Jim Barr | Bob Shirley | | 3 | 8 | -5 |
| 1978-04-09 | @ SFN | 3 | L 5-7 | 1-2 | 4 | 33,722 | Randy Jones | Lynn McGlothen | Gary Lavelle | Rollie Fingers | Randy Moffitt | 8 | 15 | -7 |
| 1978-04-10 | @ ATL | 4 | L 7-8 | 1-3 | 5 | 2,056 | Dave Freisleben | Preston Hanna | Adrian Devine | Bob Shirley | | 15 | 23 | -8 |
| 1978-04-11 | @ ATL | 5 | W 3-2 | 2-3 | 4 | 2,616 | Bob Owchinko | Phil Niekro | Rollie Fingers | Phil Niekro | | 18 | 25 | -7 |
| 1978-04-14 | vs SFN | 6 | L 2-3 | 2-4 | 4 | 45,901 | Randy Jones | Jim Barr | Randy Moffitt | Rollie Fingers | | 20 | 28 | -8 |
| 1978-04-16 | vs SFN | 7 | L 4-8 | 2-5 | 5 | 20,992 | Bob Owchinko | Bob Knepper | Bob Knepper | Bob Owchinko | Gary Lavelle | 24 | 36 | -12 |
| 1978-04-18 | vs HOU | 8 | L 1-5 | 2-6 | 5 | 10,840 | Bob Shirley | Joe Niekro | Joe Niekro | Bob Shirley | | 25 | 41 | -16 |
| 1978-04-19 | vs HOU | 9 | L 1-2 | 2-7 | 6 | 12,129 | Dave Freisleben | Joaquin Andujar | Joaquin Andujar | Dave Freisleben | Joe Sambito | 26 | 43 | -17 |
| 1978-04-20 | vs ATL | 10 | W 2-0 | 3-7 | 5 | 10,256 | Randy Jones | Phil Niekro | Randy Jones | Phil Niekro | Rollie Fingers | 28 | 43 | -15 |
| 1978-04-21 | vs ATL | 11 | W 9-3 | 4-7 | 5 | 37,113 | Gaylord Perry | Jamie Easterly | Gaylord Perry | Jamie Easterly | | 37 | 46 | -9 |
| 1978-04-22 | vs ATL | 12 | W 2-0 | 5-7 | 5 | 49,744 | Bob Owchinko | Tommy Boggs | Bob Owchinko | Tommy Boggs | Rollie Fingers | 39 | 46 | -7 |
| 1978-04-23 | vs ATL | 13 | W 5-4 | 6-7 | 4 | 19,502 | Bob Shirley | Dick Ruthven | Dave Wehrmeister | Eddie Solomon | | 44 | 50 | -6 |
| 1978-04-24 | @ HOU | 14 | L 3-4 | 6-8 | 5 | 7,300 | Dave Freisleben | Joaquin Andujar | Joe Sambito | Rollie Fingers | | 47 | 54 | -7 |
| 1978-04-25 | @ HOU | 15 | L 3-4 | 6-9 | 5 | 7,459 | Randy Jones | Mark Lemongello | Mark Lemongello | Randy Jones | | 50 | 58 | -8 |
| 1978-04-26 | @ HOU | 16 | W 2-1 | 7-9 | 4 | 8,769 | Gaylord Perry | J.R. Richard | Gaylord Perry | J.R. Richard | Rollie Fingers | 52 | 59 | -7 |
| 1978-04-28 | @ PHI | 17 | L 2-3 | 7-10 | 5 | 26,872 | Bob Owchinko | Larry Christenson | Larry Christenson | Bob Owchinko | Ron Reed | 54 | 62 | -8 |
| 1978-04-29 | @ PHI | 18 | L 2-7 | 7-11 | 5 | 28,390 | Dave Freisleben | Jim Lonborg | Jim Lonborg | Dave Freisleben | | 56 | 69 | -13 |
| 1978-04-30 | @ PHI | 19 | L 4-11 | 7-12 | 5 | 31,101 | Randy Jones | Randy Lerch | Randy Lerch | Randy Jones | | 60 | 80 | -20 |
| 1978-05-01 | @ PIT | 20 | L 4-7 | 7-13 | 5 | 2,786 | Gaylord Perry | Jim Rooker | Jim Bibby | Rollie Fingers | | 64 | 87 | -23 |
| 1978-05-02 | @ PIT | 21 | W 2-1 | 8-13 | 5 | 3,228 | Bob Owchinko | John Candelaria | Bob Owchinko | John Candelaria | | 66 | 88 | -22 |
| 1978-05-03 | @ PIT | 22 | W 7-5 | 9-13 | 5 | 5,052 | Bob Shirley | Don Robinson | John D'Acquisto | Jim Bibby | Rollie Fingers | 73 | 93 | -20 |
| 1978-05-05 | @ SLN | 23 | W 2-1 | 10-13 | 4 | 7,831 | Randy Jones | John Urrea | Randy Jones | John Urrea | Rollie Fingers | 75 | 94 | -19 |
| 1978-05-06 | @ SLN | 24 | L 0-1 | 10-14 | 4 | 13,534 | Gaylord Perry | John Denny | John Denny | Gaylord Perry | | 75 | 95 | -20 |
| 1978-05-07 | @ SLN | 25 | L 4-8 | 10-15 | 6 | 19,629 | Bob Owchinko | Bob Forsch | Bob Forsch | Dave Freisleben | | 79 | 103 | -24 |
| 1978-05-09 | vs CHN | 26 | L 5-8 | 10-16 | 6 | 15,643 | Bob Shirley | Woodie Fryman | Woodie Fryman | Bob Shirley | | 84 | 111 | -27 |
| 1978-05-10 | vs CHN | 27 | W 1-0 | 11-16 | 6 | 17,082 | Randy Jones | Dennis Lamp | Randy Jones | Dennis Lamp | | 85 | 111 | -26 |
| 1978-05-11 | vs CHN | 28 | L 3-4 | 11-17 | 6 | 14,756 | Gaylord Perry | Rick Reuschel | Guillermo Hernandez | Mark Lee | Donnie Moore | 88 | 115 | -27 |
| 1978-05-12 | vs PIT | 29 | W 6-4 | 12-17 | 5 | 20,240 | Bob Owchinko | Jim Rooker | Mark Lee | Kent Tekulve | Rollie Fingers | 94 | 119 | -25 |
| 1978-05-13 | vs PIT | 30 | W 6-5 | 13-17 | 5 | 32,648 | Bob Shirley | Jerry Reuss | Dan Spillner | Bruce Kison | Rollie Fingers | 100 | 124 | -24 |
| 1978-05-14 | vs PIT | 31 | L 0-1 | 13-18 | 5 | 18,572 | Randy Jones | Don Robinson | Don Robinson | Randy Jones | | 100 | 125 | -25 |
| 1978-05-15 | vs SLN | 32 | W 4-3 | 14-18 | 5 | 17,199 | Gaylord Perry | Bob Forsch | Mark Lee | Pete Vuckovich | | 104 | 128 | -24 |
| 1978-05-16 | vs SLN | 33 | W 7-5 | 15-18 | 5 | 14,434 | Bob Owchinko | John Urrea | Bob Owchinko | John Urrea | John D'Acquisto | 111 | 133 | -22 |
| 1978-05-17 | vs SLN | 34 | W 5-2 | 16-18 | 5 | 13,732 | Bob Shirley | Eric Rasmussen | Bob Shirley | Eric Rasmussen | Rollie Fingers | 116 | 135 | -19 |
| 1978-05-19 | @ CIN | 35 | L 3-4 | 16-19 | 5 | 36,283 | Randy Jones | Paul Moskau | Dave Tomlin | Rollie Fingers | Doug Bair | 119 | 139 | -20 |
| 1978-05-20 | @ CIN | 36 | L 6-10 | 16-20 | 5 | 35,429 | Gaylord Perry | Tom Hume | Dave Tomlin | Rollie Fingers | | 125 | 149 | -24 |
| 1978-05-21 | @ CIN | 37 | W 7-2 | 17-21 | 5 | 0 | Bob Shirley | Manny Sarmiento | Bob Shirley | Manny Sarmiento | | 132 | 151 | -19 |
| 1978-05-21 | @ CIN | 38 | L 0-1 | 17-21 | 5 | 38,295 | John D'Acquisto | Tom Seaver | Tom Seaver | John D'Acquisto | Doug Bair | 132 | 152 | -20 |
| 1978-05-22 | vs LAN | 39 | L 1-8 | 17-22 | 5 | 21,957 | Bob Owchinko | Don Sutton | Don Sutton | Bob Owchinko | | 133 | 160 | -27 |
| 1978-05-23 | vs LAN | 40 | W 3-2 | 18-22 | 5 | 27,512 | Randy Jones | Tommy John | Rollie Fingers | Tommy John | | 136 | 162 | -26 |
| 1978-05-24 | vs LAN | 41 | W 9-3 | 19-22 | 5 | 27,100 | Gaylord Perry | Rick Rhoden | Gaylord Perry | Rick Rhoden | John D'Acquisto | 145 | 165 | -20 |
| 1978-05-26 | vs CIN | 42 | L 1-3 | 19-23 | 5 | 34,227 | Bob Shirley | Tom Seaver | Tom Seaver | Bob Shirley | Doug Bair | 146 | 168 | -22 |
| 1978-05-27 | vs CIN | 43 | L 2-5 | 19-24 | 5 | 43,484 | Bob Owchinko | Bill Bonham | Bill Bonham | Bob Owchinko | | 148 | 173 | -25 |
| 1978-05-28 | vs CIN | 44 | W 3-1 | 20-24 | 4 | 34,029 | Randy Jones | Fred Norman | Randy Jones | Fred Norman | Rollie Fingers | 151 | 174 | -23 |
| 1978-05-29 | @ LAN | 45 | L 6-9 | 20-25 | 4 | 51,781 | Gaylord Perry | Tommy John | Tommy John | Gaylord Perry | | 157 | 183 | -26 |
| 1978-05-30 | @ LAN | 46 | L 2-10 | 20-26 | 4 | 31,636 | Eric Rasmussen | Rick Rhoden | Rick Rhoden | Eric Rasmussen | | 159 | 193 | -34 |
| 1978-05-31 | @ LAN | 47 | W 3-1 | 21-26 | 4 | 28,050 | Bob Shirley | Doug Rau | Bob Shirley | Doug Rau | Rollie Fingers | 162 | 194 | -32 |
| 1978-06-02 | @ NYN | 48 | W 5-4 | 22-26 | 4 | 9,943 | Randy Jones | Nino Espinosa | Randy Jones | Nino Espinosa | Rollie Fingers | 167 | 198 | -31 |
| 1978-06-03 | @ NYN | 49 | L 2-3 | 22-27 | 5 | 7,452 | Bob Owchinko | Pat Zachry | Pat Zachry | Bob Owchinko | Skip Lockwood | 169 | 201 | -32 |
| 1978-06-04 | @ NYN | 50 | W 5-2 | 23-27 | 4 | 12,887 | Gaylord Perry | Jerry Koosman | Gaylord Perry | Jerry Koosman | Rollie Fingers | 174 | 203 | -29 |
| 1978-06-05 | @ MON | 51 | L 3-4 | 23-28 | 4 | 12,909 | Eric Rasmussen | Rudy May | Rudy May | Eric Rasmussen | Mike Garman | 177 | 207 | -30 |
| 1978-06-06 | @ MON | 52 | L 0-4 | 23-29 | 4 | 13,702 | Bob Shirley | Wayne Twitchell | Wayne Twitchell | Bob Shirley | Bill Atkinson | 177 | 211 | -34 |
| 1978-06-07 | @ MON | 53 | L 3-8 | 23-30 | 4 | 11,786 | Randy Jones | Ross Grimsley | Ross Grimsley | Randy Jones | | 180 | 219 | -39 |
| 1978-06-09 | @ CHN | 54 | L 0-5 | 23-31 | 5 | 15,770 | Bob Owchinko | Dennis Lamp | Dennis Lamp | Bob Owchinko | | 180 | 224 | -44 |
| 1978-06-10 | @ CHN | 55 | W 10-8 | 24-31 | 5 | 31,807 | Gaylord Perry | Dave Roberts | Gaylord Perry | Donnie Moore | Rollie Fingers | 190 | 232 | -42 |
| 1978-06-11 | @ CHN | 56 | L 4-7 | 24-32 | 5 | 36,751 | Bob Shirley | Ray Burris | Ray Burris | Bob Shirley | Bruce Sutter | 194 | 239 | -45 |
| 1978-06-12 | vs NYN | 57 | W 3-2 | 25-32 | 5 | 19,431 | Randy Jones | Pat Zachry | Mark Lee | Pat Zachry | | 197 | 241 | -44 |
| 1978-06-13 | vs NYN | 58 | L 2-3 | 25-33 | 5 | 12,927 | Bob Owchinko | Craig Swan | Skip Lockwood | Rollie Fingers | Paul Siebert | 199 | 244 | -45 |
| 1978-06-14 | vs MON | 59 | W 6-2 | 27-33 | 5 | 0 | Eric Rasmussen | Wayne Twitchell | Eric Rasmussen | Wayne Twitchell | John D'Acquisto | 205 | 246 | -41 |
| 1978-06-14 | vs MON | 60 | W 1-0 | 27-33 | 5 | 18,765 | Gaylord Perry | Woodie Fryman | Gaylord Perry | Woodie Fryman | | 206 | 246 | -40 |
| 1978-06-15 | vs MON | 61 | L 1-3 | 27-34 | 5 | 9,253 | Bob Shirley | Ross Grimsley | Ross Grimsley | Bob Shirley | | 207 | 249 | -42 |
| 1978-06-16 | vs PHI | 62 | L 0-5 | 27-35 | 5 | 21,124 | Randy Jones | Steve Carlton | Steve Carlton | Randy Jones | | 207 | 254 | -47 |
| 1978-06-17 | vs PHI | 63 | W 7-0 | 28-35 | 5 | 27,319 | Bob Owchinko | Jim Lonborg | Bob Owchinko | Jim Lonborg | | 214 | 254 | -40 |
| 1978-06-18 | vs PHI | 64 | W 4-1 | 29-35 | 5 | 21,195 | Gaylord Perry | Dick Ruthven | Gaylord Perry | Dick Ruthven | Rollie Fingers | 218 | 255 | -37 |
| 1978-06-20 | vs ATL | 65 | L 3-5 | 29-36 | 5 | 13,059 | Randy Jones | Phil Niekro | Phil Niekro | Randy Jones | Gene Garber | 221 | 260 | -39 |
| 1978-06-21 | vs ATL | 66 | L 0-2 | 29-37 | 5 | 12,016 | Bob Shirley | Adrian Devine | Adrian Devine | Bob Shirley | Gene Garber | 221 | 262 | -41 |
| 1978-06-22 | vs ATL | 67 | W 2-0 | 30-37 | 5 | 8,854 | Bob Owchinko | Mickey Mahler | Bob Owchinko | Mickey Mahler | Rollie Fingers | 223 | 262 | -39 |
| 1978-06-23 | vs HOU | 68 | W 3-0 | 31-37 | 5 | 12,055 | Gaylord Perry | Tom Dixon | Gaylord Perry | Tom Dixon | | 226 | 262 | -36 |
| 1978-06-24 | vs HOU | 69 | W 6-5 | 32-37 | 4 | 15,759 | Randy Jones | Floyd Bannister | Rollie Fingers | Ken Forsch | | 232 | 267 | -35 |
| 1978-06-25 | vs HOU | 70 | W 6-1 | 34-37 | 4 | 0 | Bob Shirley | J.R. Richard | Bob Shirley | J.R. Richard | | 238 | 268 | -30 |
| 1978-06-25 | vs HOU | 71 | W 7-4 | 34-37 | 4 | 20,342 | Eric Rasmussen | Bo McLaughlin | Eric Rasmussen | Bo McLaughlin | John D'Acquisto | 245 | 272 | -27 |
| 1978-06-26 | vs SFN | 72 | W 2-1 | 35-37 | 4 | 28,186 | Bob Owchinko | Bob Knepper | Rollie Fingers | Gary Lavelle | | 247 | 273 | -26 |
| 1978-06-27 | vs SFN | 73 | L 1-9 | 35-38 | 4 | 34,472 | Gaylord Perry | Vida Blue | Vida Blue | Gaylord Perry | | 248 | 282 | -34 |
| 1978-06-28 | vs SFN | 74 | L 2-4 | 36-39 | 4 | 0 | Randy Jones | Jim Barr | Jim Barr | Randy Jones | Randy Moffitt | 250 | 286 | -36 |
| 1978-06-28 | vs SFN | 75 | W 4-1 | 36-39 | 4 | 29,827 | Eric Rasmussen | Charlie Williams | Eric Rasmussen | Charlie Williams | John D'Acquisto | 254 | 287 | -33 |
| 1978-06-30 | @ HOU | 76 | W 5-2 | 37-39 | 4 | 9,194 | Bob Shirley | J.R. Richard | Bob Shirley | J.R. Richard | Rollie Fingers | 259 | 289 | -30 |
| 1978-07-01 | @ HOU | 77 | L 2-9 | 38-40 | 4 | 0 | Bob Owchinko | Mark Lemongello | Mark Lemongello | Bob Owchinko | | 261 | 298 | -37 |
| 1978-07-01 | @ HOU | 78 | W 9-3 | 38-40 | 4 | 22,076 | Mark Wiley | Joe Niekro | Mark Wiley | Joe Niekro | John D'Acquisto | 270 | 301 | -31 |
| 1978-07-02 | @ HOU | 79 | W 6-2 | 39-40 | 4 | 14,737 | Gaylord Perry | Tom Dixon | Gaylord Perry | Tom Dixon | Rollie Fingers | 276 | 303 | -27 |
| 1978-07-03 | @ SFN | 80 | W 4-3 | 40-40 | 4 | 22,447 | Randy Jones | Jim Barr | Randy Jones | Jim Barr | Rollie Fingers | 280 | 306 | -26 |
| 1978-07-04 | @ SFN | 81 | W 7-5 | 41-40 | 4 | 26,219 | Eric Rasmussen | John Montefusco | Eric Rasmussen | John Montefusco | John D'Acquisto | 287 | 311 | -24 |
| 1978-07-05 | @ SFN | 82 | L 4-5 | 41-41 | 4 | 8,394 | Bob Shirley | Ed Halicki | John Curtis | Rollie Fingers | | 291 | 316 | -25 |
| 1978-07-06 | @ SFN | 83 | L 4-5 | 41-42 | 4 | 12,797 | Bob Owchinko | Bob Knepper | Bob Knepper | Randy Jones | Randy Moffitt | 295 | 321 | -26 |
| 1978-07-07 | @ ATL | 84 | L 3-11 | 41-43 | 4 | 9,605 | Gaylord Perry | Mickey Mahler | Mickey Mahler | Gaylord Perry | | 298 | 332 | -34 |
| 1978-07-08 | @ ATL | 85 | L 4-6 | 42-44 | 4 | 0 | Randy Jones | Rick Camp | Craig Skok | John D'Acquisto | Gene Garber | 302 | 338 | -36 |
| 1978-07-08 | @ ATL | 86 | W 7-0 | 42-44 | 4 | 18,794 | Eric Rasmussen | Jamie Easterly | Eric Rasmussen | Jamie Easterly | | 309 | 338 | -29 |
| 1978-07-09 | @ ATL | 87 | L 2-5 | 42-45 | 4 | 8,621 | Bob Shirley | Preston Hanna | Preston Hanna | Bob Shirley | Gene Garber | 311 | 343 | -32 |
| 1978-07-13 | @ CHN | 88 | W 5-2 | 43-45 | 4 | 21,594 | Gaylord Perry | Rick Reuschel | Gaylord Perry | Rick Reuschel | John D'Acquisto | 316 | 345 | -29 |
| 1978-07-14 | @ CHN | 89 | W 9-5 | 44-45 | 4 | 17,818 | Eric Rasmussen | Dave Roberts | Eric Rasmussen | Dave Roberts | Rollie Fingers | 325 | 350 | -25 |
| 1978-07-15 | @ CHN | 90 | L 1-3 | 44-46 | 4 | 25,511 | Randy Jones | Dennis Lamp | Bruce Sutter | John D'Acquisto | | 326 | 353 | -27 |
| 1978-07-16 | @ PIT | 91 | L 2-3 | 44-48 | 4 | 0 | Bob Owchinko | Jim Bibby | Ed Whitson | Rollie Fingers | | 328 | 356 | -28 |
| 1978-07-16 | @ PIT | 92 | L 6-10 | 44-48 | 4 | 16,303 | Bob Shirley | Jerry Reuss | Grant Jackson | Dennis Kinney | Kent Tekulve | 334 | 366 | -32 |
| 1978-07-17 | @ PIT | 93 | L 7-8 | 44-49 | 4 | 7,045 | Gaylord Perry | Bruce Kison | Kent Tekulve | Rollie Fingers | | 341 | 374 | -33 |
| 1978-07-18 | @ SLN | 94 | W 3-2 | 45-49 | 4 | 13,271 | Eric Rasmussen | Pete Vuckovich | Eric Rasmussen | Pete Vuckovich | | 344 | 376 | -32 |
| 1978-07-19 | @ SLN | 95 | W 5-3 | 46-49 | 4 | 11,053 | Randy Jones | Roy Thomas | Randy Jones | Roy Thomas | Bob Shirley | 349 | 379 | -30 |
| 1978-07-20 | @ SLN | 96 | L 2-3 | 46-50 | 4 | 8,510 | Bob Owchinko | Bob Forsch | Buddy Schultz | Rollie Fingers | Mark Littell | 351 | 382 | -31 |
| 1978-07-21 | vs CHN | 97 | L 4-5 | 46-51 | 4 | 22,982 | Gaylord Perry | Rick Reuschel | Rick Reuschel | Bob Shirley | Bruce Sutter | 355 | 387 | -32 |
| 1978-07-22 | vs CHN | 98 | W 4-2 | 47-51 | 4 | 22,258 | Eric Rasmussen | Dave Roberts | John D'Acquisto | Ray Burris | | 359 | 389 | -30 |
| 1978-07-23 | vs CHN | 99 | L 3-4 | 47-52 | 4 | 21,505 | Randy Jones | Dennis Lamp | Dennis Lamp | Randy Jones | | 362 | 393 | -31 |
| 1978-07-25 | vs PIT | 100 | W 2-1 | 48-52 | 4 | 17,522 | Bob Owchinko | Jim Rooker | Bob Owchinko | Jim Rooker | | 364 | 394 | -30 |
| 1978-07-26 | vs PIT | 101 | W 6-5 | 49-52 | 4 | 16,556 | Gaylord Perry | Bruce Kison | Gaylord Perry | Bruce Kison | Rollie Fingers | 370 | 399 | -29 |
| 1978-07-27 | vs PIT | 102 | W 6-3 | 50-52 | 4 | 14,076 | Eric Rasmussen | Jim Bibby | Bob Shirley | Ed Whitson | Rollie Fingers | 376 | 402 | -26 |
| 1978-07-28 | vs SLN | 103 | W 8-3 | 51-52 | 4 | 17,217 | Randy Jones | John Denny | Randy Jones | John Denny | | 384 | 405 | -21 |
| 1978-07-29 | vs SLN | 104 | W 7-3 | 52-52 | 4 | 18,696 | Bob Owchinko | Pete Vuckovich | Bob Owchinko | Pete Vuckovich | | 391 | 408 | -17 |
| 1978-07-30 | vs SLN | 105 | W 3-2 | 53-52 | 4 | 16,478 | Gaylord Perry | Bob Forsch | Gaylord Perry | Bob Forsch | Rollie Fingers | 394 | 410 | -16 |
| 1978-07-31 | vs LAN | 106 | W 4-3 | 54-52 | 4 | 28,592 | Eric Rasmussen | Rick Rhoden | Eric Rasmussen | Rick Rhoden | Rollie Fingers | 398 | 413 | -15 |
| 1978-08-01 | vs LAN | 107 | W 1-0 | 55-52 | 4 | 40,846 | Randy Jones | Burt Hooton | Randy Jones | Burt Hooton | | 399 | 413 | -14 |
| 1978-08-02 | vs LAN | 108 | W 2-1 | 56-52 | 4 | 46,751 | Bob Owchinko | Tommy John | Bob Owchinko | Tommy John | Rollie Fingers | 401 | 414 | -13 |
| 1978-08-04 | @ CIN | 109 | W 3-2 | 57-52 | 4 | 44,829 | Gaylord Perry | Paul Moskau | Bob Shirley | Doug Bair | Rollie Fingers | 404 | 416 | -12 |
| 1978-08-05 | @ CIN | 110 | L 1-7 | 57-53 | 4 | 40,202 | Eric Rasmussen | Mike LaCoss | Mike LaCoss | Eric Rasmussen | | 405 | 423 | -18 |
| 1978-08-06 | @ CIN | 111 | L 1-3 | 57-54 | 4 | 39,263 | Randy Jones | Bill Bonham | Fred Norman | Randy Jones | Doug Bair | 406 | 426 | -20 |
| 1978-08-07 | @ LAN | 112 | L 1-3 | 57-55 | 4 | 37,161 | Bob Owchinko | Tommy John | Tommy John | Bob Owchinko | | 407 | 429 | -22 |
| 1978-08-08 | @ LAN | 113 | L 2-3 | 57-56 | 4 | 43,515 | Gaylord Perry | Don Sutton | Don Sutton | Gaylord Perry | | 409 | 432 | -23 |
| 1978-08-09 | @ LAN | 114 | L 0-3 | 57-57 | 4 | 41,597 | Eric Rasmussen | Doug Rau | Doug Rau | Eric Rasmussen | | 409 | 435 | -26 |
| 1978-08-10 | vs CIN | 115 | W 15-3 | 58-57 | 4 | 27,882 | Randy Jones | Mike LaCoss | Randy Jones | Mike LaCoss | Bob Shirley | 424 | 438 | -14 |
| 1978-08-11 | vs CIN | 116 | L 0-2 | 58-58 | 4 | 33,635 | Bob Owchinko | Bill Bonham | Doug Bair | Bob Owchinko | | 424 | 440 | -16 |
| 1978-08-12 | vs CIN | 117 | W 4-2 | 59-58 | 4 | 38,543 | Gaylord Perry | Tom Seaver | Gaylord Perry | Tom Seaver | Rollie Fingers | 428 | 442 | -14 |
| 1978-08-13 | vs CIN | 118 | W 3-2 | 60-58 | 4 | 34,267 | Eric Rasmussen | Fred Norman | Eric Rasmussen | Fred Norman | Bob Shirley | 431 | 444 | -13 |
| 1978-08-15 | @ NYN | 119 | L 1-3 | 60-59 | 4 | 9,956 | Randy Jones | Craig Swan | Craig Swan | Randy Jones | Skip Lockwood | 432 | 447 | -15 |
| 1978-08-16 | @ NYN | 120 | W 2-1 | 61-59 | 4 | 10,263 | Bob Owchinko | Jerry Koosman | John D'Acquisto | Skip Lockwood | | 434 | 448 | -14 |
| 1978-08-17 | @ NYN | 121 | W 9-2 | 62-59 | 4 | 9,003 | Gaylord Perry | Juan Berenguer | Gaylord Perry | Juan Berenguer | Mickey Lolich | 443 | 450 | -7 |
| 1978-08-18 | @ MON | 122 | W 3-2 | 63-59 | 4 | 17,042 | Eric Rasmussen | Steve Rogers | Eric Rasmussen | Steve Rogers | Mark Lee | 446 | 452 | -6 |
| 1978-08-19 | @ MON | 123 | W 3-2 | 64-59 | 4 | 21,676 | Randy Jones | Dan Schatzeder | Randy Jones | Dan Schatzeder | Rollie Fingers | 449 | 454 | -5 |
| 1978-08-20 | @ MON | 124 | W 5-4 | 65-59 | 4 | 20,094 | Bob Owchinko | Woodie Fryman | Mark Lee | Hal Dues | Rollie Fingers | 454 | 458 | -4 |
| 1978-08-21 | @ PHI | 125 | W 7-3 | 66-59 | 4 | 27,124 | Gaylord Perry | Randy Lerch | Gaylord Perry | Warren Brusstar | Bob Shirley | 461 | 461 | 0 |
| 1978-08-22 | @ PHI | 126 | L 3-5 | 66-60 | 4 | 36,339 | Eric Rasmussen | Larry Christenson | Larry Christenson | Eric Rasmussen | Ron Reed | 464 | 466 | -2 |
| 1978-08-23 | @ PHI | 127 | W 6-5 | 67-60 | 4 | 31,032 | Randy Jones | Jim Kaat | Rollie Fingers | Ron Reed | | 470 | 471 | -1 |
| 1978-08-24 | vs NYN | 128 | L 3-6 | 67-61 | 4 | 17,613 | Bob Owchinko | Mike Bruhert | Mike Bruhert | Bob Owchinko | | 473 | 477 | -4 |
| 1978-08-25 | vs NYN | 129 | L 1-2 | 67-62 | 4 | 19,459 | Gaylord Perry | Craig Swan | Craig Swan | Gaylord Perry | | 474 | 479 | -5 |
| 1978-08-26 | vs NYN | 130 | W 2-1 | 68-62 | 4 | 16,458 | Mickey Lolich | Jerry Koosman | Mickey Lolich | Jerry Koosman | Rollie Fingers | 476 | 480 | -4 |
| 1978-08-27 | vs NYN | 131 | W 3-0 | 69-62 | 4 | 16,503 | Eric Rasmussen | Nino Espinosa | Eric Rasmussen | Nino Espinosa | | 479 | 480 | -1 |
| 1978-08-28 | vs PHI | 132 | L 1-6 | 69-63 | 4 | 33,768 | Randy Jones | Jim Kaat | Jim Kaat | Randy Jones | | 480 | 486 | -6 |
| 1978-08-29 | vs PHI | 133 | L 5-9 | 69-64 | 4 | 13,568 | Bob Owchinko | Dick Ruthven | Dick Ruthven | Bob Owchinko | | 485 | 495 | -10 |
| 1978-08-30 | vs PHI | 134 | L 5-6 | 69-65 | 4 | 15,941 | Gaylord Perry | Randy Lerch | Warren Brusstar | Rollie Fingers | | 490 | 501 | -11 |
| 1978-08-31 | vs MON | 135 | W 6-1 | 70-65 | 4 | 11,810 | Eric Rasmussen | Woodie Fryman | Eric Rasmussen | Woodie Fryman | Mark Lee | 496 | 502 | -6 |
| 1978-09-01 | vs MON | 136 | L 2-3 | 70-66 | 4 | 14,346 | Randy Jones | Ross Grimsley | Mike Garman | Randy Jones | | 498 | 505 | -7 |
| 1978-09-02 | vs MON | 137 | L 2-3 | 70-67 | 4 | 18,142 | Mickey Lolich | Scott Sanderson | Scott Sanderson | Mickey Lolich | Mike Garman | 500 | 508 | -8 |
| 1978-09-04 | @ ATL | 138 | W 8-4 | 71-67 | 4 | 3,079 | Gaylord Perry | Larry McWilliams | Gaylord Perry | Larry McWilliams | John D'Acquisto | 508 | 512 | -4 |
| 1978-09-05 | @ ATL | 139 | L 1-8 | 71-68 | 4 | 1,192 | Eric Rasmussen | Phil Niekro | Phil Niekro | Eric Rasmussen | | 509 | 520 | -11 |
| 1978-09-06 | @ ATL | 140 | W 5-3 | 72-68 | 4 | 1,519 | Randy Jones | Mickey Mahler | Mark Lee | Gene Garber | Rollie Fingers | 514 | 523 | -9 |
| 1978-09-07 | @ CIN | 141 | L 2-6 | 72-69 | 4 | 20,611 | Bob Owchinko | Paul Moskau | Paul Moskau | Bob Owchinko | Fred Norman | 516 | 529 | -13 |
| 1978-09-08 | @ CIN | 142 | W 3-2 | 73-69 | 4 | 27,205 | Gaylord Perry | Mike LaCoss | Gaylord Perry | Mike LaCoss | Rollie Fingers | 519 | 531 | -12 |
| 1978-09-09 | @ HOU | 143 | L 4-10 | 73-70 | 4 | 8,240 | Steve Mura | Joe Niekro | Joe Niekro | Steve Mura | | 523 | 541 | -18 |
| 1978-09-10 | @ HOU | 144 | L 2-3 | 73-71 | 4 | 5,720 | Eric Rasmussen | J.R. Richard | J.R. Richard | Eric Rasmussen | | 525 | 544 | -19 |
| 1978-09-11 | vs ATL | 145 | L 2-7 | 73-72 | 4 | 9,727 | Randy Jones | Larry McWilliams | Larry McWilliams | Randy Jones | | 527 | 551 | -24 |
| 1978-09-12 | vs ATL | 146 | W 3-1 | 74-72 | 4 | 11,222 | Gaylord Perry | Mickey Mahler | Gaylord Perry | Mickey Mahler | | 530 | 552 | -22 |
| 1978-09-13 | vs CIN | 147 | W 6-2 | 75-72 | 4 | 12,899 | Bob Owchinko | Mike LaCoss | Bob Owchinko | Manny Sarmiento | Rollie Fingers | 536 | 554 | -18 |
| 1978-09-14 | vs CIN | 148 | W 8-1 | 76-72 | 4 | 10,223 | Bob Shirley | Bill Bonham | Bob Shirley | Bill Bonham | John D'Acquisto | 544 | 555 | -11 |
| 1978-09-15 | vs HOU | 149 | L 4-8 | 76-73 | 4 | 6,866 | Eric Rasmussen | J.R. Richard | J.R. Richard | Eric Rasmussen | | 548 | 563 | -15 |
| 1978-09-16 | vs HOU | 150 | W 2-1 | 77-73 | 4 | 10,171 | Gaylord Perry | Vern Ruhle | Gaylord Perry | Joe Sambito | | 550 | 564 | -14 |
| 1978-09-17 | vs HOU | 151 | W 3-1 | 78-73 | 4 | 10,004 | Randy Jones | Mark Lemongello | Randy Jones | Mark Lemongello | Rollie Fingers | 553 | 565 | -12 |
| 1978-09-19 | vs SFN | 152 | W 4-1 | 79-73 | 4 | 10,969 | Bob Owchinko | Ed Halicki | Bob Owchinko | Ed Halicki | Rollie Fingers | 557 | 566 | -9 |
| 1978-09-20 | vs SFN | 153 | L 3-6 | 79-74 | 4 | 13,123 | Eric Rasmussen | Vida Blue | Vida Blue | Eric Rasmussen | Gary Lavelle | 560 | 572 | -12 |
| 1978-09-21 | vs SFN | 154 | W 5-1 | 80-74 | 4 | 13,329 | Gaylord Perry | John Montefusco | Gaylord Perry | John Montefusco | | 565 | 573 | -8 |
| 1978-09-22 | @ LAN | 155 | W 12-3 | 81-74 | 4 | 38,743 | Randy Jones | Doug Rau | Randy Jones | Doug Rau | Bob Shirley | 577 | 576 | 1 |
| 1978-09-23 | @ LAN | 156 | L 3-5 | 81-75 | 4 | 31,653 | John D'Acquisto | Burt Hooton | Burt Hooton | Rollie Fingers | Terry Forster | 580 | 581 | -1 |
| 1978-09-24 | @ LAN | 157 | L 0-4 | 81-76 | 4 | 50,018 | Bob Owchinko | Bob Welch | Bob Welch | Bob Owchinko | | 580 | 585 | -5 |
| 1978-09-26 | @ SFN | 158 | W 4-1 | 82-76 | 4 | 6,227 | Gaylord Perry | John Montefusco | Gaylord Perry | John Montefusco | Rollie Fingers | 584 | 586 | -2 |
| 1978-09-27 | @ SFN | 159 | L 0-1 | 82-77 | 4 | 4,708 | Eric Rasmussen | Bob Knepper | Bob Knepper | Eric Rasmussen | | 584 | 587 | -3 |
| 1978-09-29 | vs LAN | 160 | W 3-1 | 83-77 | 4 | 26,002 | John D'Acquisto | Burt Hooton | John D'Acquisto | Burt Hooton | Rollie Fingers | 587 | 588 | -1 |
| 1978-09-30 | vs LAN | 161 | L 0-7 | 83-78 | 4 | 38,539 | Steve Mura | Tommy John | Tommy John | Steve Mura | | 587 | 595 | -8 |
| 1978-10-01 | vs LAN | 162 | W 4-3 | 84-78 | 4 | 37,185 | Gaylord Perry | Don Sutton | Rollie Fingers | Bobby Castillo | | 591 | 598 | -7 |