| 1978-04-07 | vs CHN | 1 | W 1-0 | 1-0 | 2 | 39,028 | John Candelaria | Rick Reuschel | John Candelaria | Rick Reuschel | | 1 | 0 | 1 |
| 1978-04-08 | vs CHN | 2 | W 4-3 | 2-0 | 2 | 9,387 | Bert Blyleven | Ray Burris | Jim Bibby | Bruce Sutter | | 5 | 3 | 2 |
| 1978-04-09 | vs CHN | 3 | L 3-4 | 2-1 | 3 | 11,632 | Jerry Reuss | Woodie Fryman | Donnie Moore | Bruce Kison | Bruce Sutter | 8 | 7 | 1 |
| 1978-04-10 | @ SLN | 4 | L 2-11 | 2-2 | 3 | 19,241 | Jim Rooker | John Denny | John Denny | Jim Rooker | | 10 | 18 | -8 |
| 1978-04-12 | @ SLN | 5 | L 1-5 | 2-3 | 6 | 12,294 | John Candelaria | Bob Forsch | Bob Forsch | John Candelaria | | 11 | 23 | -12 |
| 1978-04-13 | @ SLN | 6 | L 5-6 | 2-4 | 6 | 12,351 | Bert Blyleven | Eric Rasmussen | Eric Rasmussen | Bert Blyleven | | 16 | 29 | -13 |
| 1978-04-14 | @ CHN | 7 | L 4-5 | 2-5 | 6 | 45,777 | Jerry Reuss | Woodie Fryman | Guillermo Hernandez | Jim Bibby | | 20 | 34 | -14 |
| 1978-04-15 | @ CHN | 8 | W 13-10 | 3-5 | 6 | 20,684 | Jim Rooker | Dennis Lamp | Jim Rooker | Dennis Lamp | | 33 | 44 | -11 |
| 1978-04-16 | @ CHN | 9 | L 1-5 | 3-6 | 6 | 20,921 | Don Robinson | Rick Reuschel | Rick Reuschel | Don Robinson | | 34 | 49 | -15 |
| 1978-04-17 | vs PHI | 10 | L 2-6 | 3-7 | 6 | 7,343 | John Candelaria | Jim Lonborg | Jim Lonborg | John Candelaria | | 36 | 55 | -19 |
| 1978-04-22 | vs SLN | 11 | W 8-7 | 4-7 | 6 | 5,173 | Bert Blyleven | John Denny | Kent Tekulve | John Urrea | | 44 | 62 | -18 |
| 1978-04-23 | vs SLN | 12 | W 14-7 | 6-7 | 4 | 0 | John Candelaria | Bob Forsch | Bruce Kison | Bob Forsch | | 58 | 69 | -11 |
| 1978-04-23 | vs SLN | 13 | W 5-4 | 6-7 | 4 | 10,008 | Jerry Reuss | Pete Falcone | Jim Bibby | Pete Vuckovich | Don Robinson | 63 | 73 | -10 |
| 1978-04-24 | @ NYN | 14 | W 4-2 | 7-7 | 5 | 9,495 | Jim Rooker | Pat Zachry | Kent Tekulve | Mardie Cornejo | | 67 | 75 | -8 |
| 1978-04-25 | @ NYN | 15 | W 2-1 | 8-7 | 3 | 6,914 | Don Robinson | Mike Bruhert | Don Robinson | Mike Bruhert | | 69 | 76 | -7 |
| 1978-04-26 | @ NYN | 16 | W 1-0 | 9-7 | 2 | 6,506 | Bert Blyleven | Craig Swan | Bert Blyleven | Bob Myrick | | 70 | 76 | -6 |
| 1978-04-28 | vs SFN | 17 | L 4-5 | 9-8 | 4 | 7,881 | John Candelaria | John Montefusco | John Montefusco | John Candelaria | Gary Lavelle | 74 | 81 | -7 |
| 1978-04-29 | vs SFN | 18 | W 6-2 | 10-8 | 3 | 7,976 | Don Robinson | Jim Barr | Don Robinson | Jim Barr | | 80 | 83 | -3 |
| 1978-04-30 | vs SFN | 19 | L 3-7 | 10-9 | 4 | 7,929 | Bert Blyleven | Bob Knepper | Bob Knepper | Bert Blyleven | | 83 | 90 | -7 |
| 1978-05-01 | vs SDN | 20 | W 7-4 | 11-9 | 4 | 2,786 | Jim Rooker | Gaylord Perry | Jim Bibby | Rollie Fingers | | 90 | 94 | -4 |
| 1978-05-02 | vs SDN | 21 | L 1-2 | 11-10 | 4 | 3,228 | John Candelaria | Bob Owchinko | Bob Owchinko | John Candelaria | | 91 | 96 | -5 |
| 1978-05-03 | vs SDN | 22 | L 5-7 | 11-11 | 4 | 5,052 | Don Robinson | Bob Shirley | John D'Acquisto | Jim Bibby | Rollie Fingers | 96 | 103 | -7 |
| 1978-05-05 | vs LAN | 23 | L 2-7 | 11-12 | 4 | 7,580 | Bert Blyleven | Burt Hooton | Burt Hooton | Bert Blyleven | | 98 | 110 | -12 |
| 1978-05-06 | vs LAN | 24 | W 3-2 | 12-12 | 4 | 8,919 | John Candelaria | Don Sutton | John Candelaria | Don Sutton | Grant Jackson | 101 | 112 | -11 |
| 1978-05-07 | vs LAN | 25 | W 6-4 | 13-12 | 3 | 18,208 | Jim Rooker | Tommy John | Jim Rooker | Tommy John | Kent Tekulve | 107 | 116 | -9 |
| 1978-05-09 | @ SFN | 26 | L 2-3 | 13-13 | 4 | 10,459 | Don Robinson | John Montefusco | John Curtis | Kent Tekulve | | 109 | 119 | -10 |
| 1978-05-10 | @ SFN | 27 | W 5-1 | 14-13 | 3 | 4,766 | Bert Blyleven | Jim Barr | Bert Blyleven | Jim Barr | | 114 | 120 | -6 |
| 1978-05-11 | @ SFN | 28 | L 2-6 | 14-14 | 4 | 6,071 | John Candelaria | Bob Knepper | Bob Knepper | John Candelaria | | 116 | 126 | -10 |
| 1978-05-12 | @ SDN | 29 | L 4-6 | 14-15 | 4 | 20,240 | Jim Rooker | Bob Owchinko | Mark Lee | Kent Tekulve | Rollie Fingers | 120 | 132 | -12 |
| 1978-05-13 | @ SDN | 30 | L 5-6 | 14-16 | 4 | 32,648 | Jerry Reuss | Bob Shirley | Dan Spillner | Bruce Kison | Rollie Fingers | 125 | 138 | -13 |
| 1978-05-14 | @ SDN | 31 | W 1-0 | 15-16 | 4 | 18,572 | Don Robinson | Randy Jones | Don Robinson | Randy Jones | | 126 | 138 | -12 |
| 1978-05-15 | @ LAN | 32 | L 6-7 | 15-17 | 4 | 35,297 | Bert Blyleven | Burt Hooton | Charlie Hough | Bert Blyleven | | 132 | 145 | -13 |
| 1978-05-16 | @ LAN | 33 | L 2-3 | 15-18 | 4 | 32,243 | John Candelaria | Don Sutton | Don Sutton | John Candelaria | Terry Forster | 134 | 148 | -14 |
| 1978-05-17 | @ LAN | 34 | L 1-10 | 15-19 | 4 | 33,097 | Jim Rooker | Tommy John | Tommy John | Jim Rooker | | 135 | 158 | -23 |
| 1978-05-19 | @ MON | 35 | W 5-3 | 16-19 | 4 | 13,088 | Don Robinson | Rudy May | Don Robinson | Rudy May | Kent Tekulve | 140 | 161 | -21 |
| 1978-05-20 | @ MON | 36 | W 6-0 | 17-19 | 4 | 13,834 | Bert Blyleven | Wayne Twitchell | Bert Blyleven | Wayne Twitchell | | 146 | 161 | -15 |
| 1978-05-21 | @ MON | 37 | W 7-0 | 18-19 | 4 | 20,016 | John Candelaria | Ross Grimsley | John Candelaria | Ross Grimsley | Kent Tekulve | 153 | 161 | -8 |
| 1978-05-22 | @ MON | 38 | L 2-5 | 18-20 | 4 | 12,300 | Jim Rooker | Steve Rogers | Steve Rogers | Jim Rooker | Darold Knowles | 155 | 166 | -11 |
| 1978-05-23 | vs NYN | 39 | L 3-7 | 18-21 | 5 | 2,869 | Jerry Reuss | Nino Espinosa | Nino Espinosa | Grant Jackson | Skip Lockwood | 158 | 173 | -15 |
| 1978-05-24 | vs NYN | 40 | W 6-5 | 19-21 | 4 | 5,302 | Don Robinson | Pat Zachry | Kent Tekulve | Skip Lockwood | | 164 | 178 | -14 |
| 1978-05-25 | vs NYN | 41 | L 2-3 | 19-22 | 5 | 5,766 | Bert Blyleven | Craig Swan | Dale Murray | Kent Tekulve | | 166 | 181 | -15 |
| 1978-05-26 | vs MON | 42 | W 2-1 | 20-22 | 4 | 8,816 | John Candelaria | Steve Rogers | John Candelaria | Steve Rogers | Kent Tekulve | 168 | 182 | -14 |
| 1978-05-27 | vs MON | 43 | L 1-15 | 20-23 | 5 | 10,773 | Jim Rooker | Rudy May | Rudy May | Jim Rooker | | 169 | 197 | -28 |
| 1978-05-28 | vs MON | 44 | W 5-2 | 21-23 | 5 | 26,564 | Jim Bibby | Hal Dues | Jim Bibby | Hal Dues | | 174 | 199 | -25 |
| 1978-05-29 | @ PHI | 45 | L 3-4 | 21-24 | 5 | 34,353 | Don Robinson | Jim Kaat | Warren Brusstar | Dave Hamilton | | 177 | 203 | -26 |
| 1978-05-30 | @ PHI | 46 | L 1-6 | 21-25 | 5 | 26,123 | Bert Blyleven | Steve Carlton | Steve Carlton | Bert Blyleven | | 178 | 209 | -31 |
| 1978-05-31 | @ PHI | 47 | W 2-1 | 22-25 | 4 | 29,595 | John Candelaria | Randy Lerch | John Candelaria | Randy Lerch | Kent Tekulve | 180 | 210 | -30 |
| 1978-06-02 | @ CIN | 48 | L 2-3 | 22-26 | 4 | 40,495 | Jim Rooker | Bill Bonham | Dave Tomlin | Jim Rooker | | 182 | 213 | -31 |
| 1978-06-03 | @ CIN | 49 | L 3-4 | 22-27 | 5 | 50,152 | Don Robinson | Fred Norman | Fred Norman | Don Robinson | Manny Sarmiento | 185 | 217 | -32 |
| 1978-06-04 | @ CIN | 50 | W 4-1 | 23-27 | 4 | 37,304 | Bert Blyleven | Paul Moskau | Bert Blyleven | Paul Moskau | Grant Jackson | 189 | 218 | -29 |
| 1978-06-05 | vs ATL | 51 | L 4-8 | 23-28 | 5 | 5,248 | John Candelaria | Dick Ruthven | Jamie Easterly | Kent Tekulve | | 193 | 226 | -33 |
| 1978-06-06 | vs ATL | 52 | W 4-2 | 24-28 | 4 | 4,914 | Jim Bibby | Adrian Devine | Jim Bibby | Adrian Devine | Kent Tekulve | 197 | 228 | -31 |
| 1978-06-09 | vs CIN | 53 | W 11-9 | 25-28 | 5 | 21,710 | Don Robinson | Paul Moskau | Grant Jackson | Doug Bair | John Candelaria | 208 | 237 | -29 |
| 1978-06-10 | vs CIN | 54 | L 4-6 | 25-29 | 5 | 34,009 | Bert Blyleven | Tom Seaver | Tom Seaver | Grant Jackson | | 212 | 243 | -31 |
| 1978-06-11 | vs CIN | 55 | W 3-1 | 26-29 | 4 | 24,972 | Jim Rooker | Tom Hume | Grant Jackson | Manny Sarmiento | Ed Whitson | 215 | 244 | -29 |
| 1978-06-12 | @ HOU | 56 | L 5-6 | 26-30 | 4 | 9,886 | John Candelaria | Tom Dixon | Rick Williams | Ed Whitson | Joe Sambito | 220 | 250 | -30 |
| 1978-06-13 | @ HOU | 57 | L 1-2 | 26-31 | 5 | 10,487 | Jim Bibby | Floyd Bannister | Ken Forsch | Jim Bibby | Joe Sambito | 221 | 252 | -31 |
| 1978-06-14 | @ HOU | 58 | W 6-4 | 27-31 | 4 | 12,440 | Don Robinson | J.R. Richard | Ed Whitson | J.R. Richard | Kent Tekulve | 227 | 256 | -29 |
| 1978-06-16 | @ ATL | 59 | W 9-4 | 28-31 | 4 | 18,572 | Bert Blyleven | Phil Niekro | Bert Blyleven | Phil Niekro | Ed Whitson | 236 | 260 | -24 |
| 1978-06-17 | @ ATL | 60 | W 5-3 | 29-31 | 4 | 16,284 | John Candelaria | Mickey Mahler | John Candelaria | Mickey Mahler | Grant Jackson | 241 | 263 | -22 |
| 1978-06-18 | @ ATL | 61 | L 7-8 | 29-32 | 4 | 21,498 | Jim Bibby | Preston Hanna | Preston Hanna | Jim Bibby | Craig Skok | 248 | 271 | -23 |
| 1978-06-19 | vs CHN | 62 | L 4-6 | 29-33 | 4 | 8,878 | Jim Rooker | Dave Roberts | Bruce Sutter | Grant Jackson | Guillermo Hernandez | 252 | 277 | -25 |
| 1978-06-20 | vs CHN | 63 | W 6-1 | 30-33 | 4 | 10,912 | Bert Blyleven | Ken Holtzman | Bert Blyleven | Ken Holtzman | | 258 | 278 | -20 |
| 1978-06-21 | vs CHN | 64 | W 2-1 | 31-33 | 4 | 11,064 | John Candelaria | Ray Burris | John Candelaria | Ray Burris | | 260 | 279 | -19 |
| 1978-06-23 | @ NYN | 65 | L 2-3 | 31-34 | 4 | 16,594 | Don Robinson | Jerry Koosman | Dale Murray | Ed Whitson | | 262 | 282 | -20 |
| 1978-06-24 | @ NYN | 66 | W 7-4 | 32-34 | 4 | 17,810 | Jim Bibby | Craig Swan | Kent Tekulve | Paul Siebert | Dave Hamilton | 269 | 286 | -17 |
| 1978-06-25 | @ NYN | 67 | W 4-0 | 33-34 | 4 | 16,748 | Bert Blyleven | Nino Espinosa | Bert Blyleven | Nino Espinosa | | 273 | 286 | -13 |
| 1978-06-26 | vs SLN | 68 | W 11-8 | 34-34 | 4 | 5,045 | Jim Rooker | John Denny | Ed Whitson | John Urrea | Kent Tekulve | 284 | 294 | -10 |
| 1978-06-27 | vs SLN | 69 | L 0-2 | 34-36 | 4 | 0 | John Candelaria | Pete Vuckovich | Pete Vuckovich | John Candelaria | Buddy Schultz | 284 | 296 | -12 |
| 1978-06-27 | vs SLN | 70 | L 1-6 | 34-36 | 4 | 9,229 | Jerry Reuss | Pete Falcone | Pete Falcone | Jerry Reuss | | 285 | 302 | -17 |
| 1978-06-28 | vs SLN | 71 | L 5-7 | 34-37 | 4 | 7,742 | Jim Bibby | Silvio Martinez | Roy Thomas | Kent Tekulve | | 290 | 309 | -19 |
| 1978-06-29 | vs NYN | 72 | W 4-3 | 35-37 | 4 | 6,367 | Bert Blyleven | Craig Swan | Grant Jackson | Skip Lockwood | Ed Whitson | 294 | 312 | -18 |
| 1978-06-30 | vs NYN | 73 | L 5-6 | 35-38 | 4 | 31,947 | Don Robinson | Nino Espinosa | Dale Murray | Dave Hamilton | | 299 | 318 | -19 |
| 1978-07-01 | vs NYN | 74 | W 1-0 | 36-38 | 4 | 7,912 | Jim Rooker | Kevin Kobel | Jim Rooker | Skip Lockwood | Kent Tekulve | 300 | 318 | -18 |
| 1978-07-03 | vs MON | 75 | L 0-2 | 36-39 | 4 | 7,480 | John Candelaria | Hal Dues | Hal Dues | John Candelaria | Steve Rogers | 300 | 320 | -20 |
| 1978-07-04 | vs MON | 76 | W 3-1 | 38-39 | 3 | 0 | Bert Blyleven | Dan Schatzeder | Bert Blyleven | Dan Schatzeder | Kent Tekulve | 303 | 321 | -18 |
| 1978-07-04 | vs MON | 77 | W 4-3 | 38-39 | 3 | 15,001 | Don Robinson | Wayne Twitchell | Don Robinson | Wayne Twitchell | Kent Tekulve | 307 | 324 | -17 |
| 1978-07-06 | @ SLN | 78 | L 2-3 | 38-40 | 3 | 14,832 | Jim Rooker | John Denny | John Denny | Jim Rooker | | 309 | 327 | -18 |
| 1978-07-07 | @ SLN | 79 | W 2-1 | 39-40 | 3 | 13,813 | John Candelaria | Pete Vuckovich | John Candelaria | Pete Vuckovich | Kent Tekulve | 311 | 328 | -17 |
| 1978-07-08 | @ SLN | 80 | L 0-4 | 39-41 | 3 | 20,524 | Don Robinson | Silvio Martinez | Silvio Martinez | Don Robinson | | 311 | 332 | -21 |
| 1978-07-09 | @ SLN | 81 | W 6-1 | 40-41 | 3 | 22,101 | Bert Blyleven | Bob Forsch | Bert Blyleven | Bob Forsch | Kent Tekulve | 317 | 333 | -16 |
| 1978-07-13 | vs SFN | 82 | L 0-4 | 40-42 | 3 | 13,984 | John Candelaria | Bob Knepper | Bob Knepper | John Candelaria | | 317 | 337 | -20 |
| 1978-07-14 | vs SFN | 83 | W 5-2 | 41-42 | 3 | 15,733 | Jim Rooker | John Montefusco | Jim Rooker | John Montefusco | Kent Tekulve | 322 | 339 | -17 |
| 1978-07-15 | vs SFN | 84 | L 5-6 | 41-43 | 3 | 16,174 | Bert Blyleven | Vida Blue | Gary Lavelle | Ed Whitson | | 327 | 345 | -18 |
| 1978-07-16 | vs SDN | 85 | W 3-2 | 43-43 | 3 | 0 | Jim Bibby | Bob Owchinko | Ed Whitson | Rollie Fingers | | 330 | 347 | -17 |
| 1978-07-16 | vs SDN | 86 | W 10-6 | 43-43 | 3 | 16,303 | Jerry Reuss | Bob Shirley | Grant Jackson | Dennis Kinney | Kent Tekulve | 340 | 353 | -13 |
| 1978-07-17 | vs SDN | 87 | W 8-7 | 44-43 | 3 | 7,045 | Bruce Kison | Gaylord Perry | Kent Tekulve | Rollie Fingers | | 348 | 360 | -12 |
| 1978-07-18 | vs LAN | 88 | L 2-7 | 44-44 | 3 | 15,125 | Don Robinson | Don Sutton | Don Sutton | Don Robinson | | 350 | 367 | -17 |
| 1978-07-19 | vs LAN | 89 | W 6-3 | 45-44 | 3 | 15,527 | Jim Rooker | Doug Rau | Jim Rooker | Doug Rau | Kent Tekulve | 356 | 370 | -14 |
| 1978-07-20 | vs LAN | 90 | W 7-6 | 46-44 | 2 | 13,823 | Bert Blyleven | Rick Rhoden | Bruce Kison | Terry Forster | | 363 | 376 | -13 |
| 1978-07-21 | @ SFN | 91 | W 3-0 | 47-44 | 2 | 23,882 | Jim Bibby | Bob Knepper | Jim Bibby | Bob Knepper | | 366 | 376 | -10 |
| 1978-07-22 | @ SFN | 92 | L 2-3 | 47-45 | 2 | 18,872 | Don Robinson | John Montefusco | John Curtis | Kent Tekulve | | 368 | 379 | -11 |
| 1978-07-23 | @ SFN | 93 | L 1-3 | 47-46 | 3 | 41,923 | John Candelaria | Jim Barr | Jim Barr | John Candelaria | | 369 | 382 | -13 |
| 1978-07-25 | @ SDN | 94 | L 1-2 | 47-47 | 3 | 17,522 | Jim Rooker | Bob Owchinko | Bob Owchinko | Jim Rooker | | 370 | 384 | -14 |
| 1978-07-26 | @ SDN | 95 | L 5-6 | 47-48 | 3 | 16,556 | Bruce Kison | Gaylord Perry | Gaylord Perry | Bruce Kison | Rollie Fingers | 375 | 390 | -15 |
| 1978-07-27 | @ SDN | 96 | L 3-6 | 47-49 | 3 | 14,076 | Jim Bibby | Eric Rasmussen | Bob Shirley | Ed Whitson | Rollie Fingers | 378 | 396 | -18 |
| 1978-07-28 | @ LAN | 97 | L 3-7 | 47-50 | 3 | 43,600 | John Candelaria | Tommy John | Tommy John | John Candelaria | Terry Forster | 381 | 403 | -22 |
| 1978-07-29 | @ LAN | 98 | L 1-2 | 47-51 | 3 | 46,139 | Don Robinson | Don Sutton | Don Sutton | Don Robinson | | 382 | 405 | -23 |
| 1978-07-30 | @ LAN | 99 | W 5-3 | 48-51 | 3 | 48,587 | Jim Rooker | Doug Rau | Jim Rooker | Doug Rau | Kent Tekulve | 387 | 408 | -21 |
| 1978-07-31 | @ MON | 100 | L 2-3 | 48-52 | 3 | 22,152 | Bert Blyleven | Ross Grimsley | Mike Garman | Bert Blyleven | | 389 | 411 | -22 |
| 1978-08-01 | @ MON | 101 | L 3-4 | 48-53 | 3 | 21,287 | Jim Bibby | Steve Rogers | Steve Rogers | Jim Bibby | Darold Knowles | 392 | 415 | -23 |
| 1978-08-02 | @ MON | 102 | W 3-0 | 49-53 | 3 | 15,378 | Bruce Kison | Dan Schatzeder | Bruce Kison | Dan Schatzeder | Kent Tekulve | 395 | 415 | -20 |
| 1978-08-04 | vs PHI | 103 | L 0-2 | 50-54 | 3 | 0 | Jim Rooker | Larry Christenson | Larry Christenson | Jim Rooker | | 395 | 417 | -22 |
| 1978-08-04 | vs PHI | 104 | W 5-2 | 50-54 | 3 | 30,865 | Don Robinson | Jim Kaat | Don Robinson | Jim Kaat | | 400 | 419 | -19 |
| 1978-08-06 | vs PHI | 105 | L 2-3 | 50-56 | 3 | 0 | Bert Blyleven | Dick Ruthven | Dick Ruthven | Bert Blyleven | | 402 | 422 | -20 |
| 1978-08-06 | vs PHI | 106 | L 0-5 | 50-56 | 3 | 31,141 | Jim Bibby | Steve Carlton | Steve Carlton | Jim Bibby | | 402 | 427 | -25 |
| 1978-08-07 | @ CHN | 107 | L 4-5 | 50-57 | 4 | 18,615 | Jerry Reuss | Mike Krukow | Donnie Moore | Jerry Reuss | Bruce Sutter | 406 | 432 | -26 |
| 1978-08-08 | @ CHN | 108 | W 9-5 | 51-57 | 4 | 26,037 | Don Robinson | Rick Reuschel | Don Robinson | Rick Reuschel | | 415 | 437 | -22 |
| 1978-08-09 | @ CHN | 109 | L 4-5 | 51-58 | 4 | 23,310 | Jim Rooker | Dave Roberts | Dave Roberts | Ed Whitson | | 419 | 442 | -23 |
| 1978-08-10 | @ PHI | 110 | L 1-3 | 51-59 | 4 | 34,672 | Bert Blyleven | Dick Ruthven | Dick Ruthven | Bert Blyleven | | 420 | 445 | -25 |
| 1978-08-11 | @ PHI | 111 | L 4-15 | 51-60 | 4 | 35,101 | Bruce Kison | Steve Carlton | Steve Carlton | Bruce Kison | | 424 | 460 | -36 |
| 1978-08-12 | @ PHI | 112 | L 1-10 | 51-61 | 4 | 30,110 | Jim Bibby | Randy Lerch | Randy Lerch | Jim Bibby | | 425 | 470 | -45 |
| 1978-08-13 | @ PHI | 113 | W 7-3 | 52-61 | 4 | 38,119 | Don Robinson | Larry Christenson | Don Robinson | Larry Christenson | | 432 | 473 | -41 |
| 1978-08-14 | vs CIN | 114 | W 7-4 | 53-61 | 4 | 26,514 | Jim Rooker | Paul Moskau | Jim Rooker | Paul Moskau | Kent Tekulve | 439 | 477 | -38 |
| 1978-08-15 | vs CIN | 115 | L 3-4 | 53-62 | 4 | 16,400 | Bert Blyleven | Mike LaCoss | Doug Bair | Ed Whitson | | 442 | 481 | -39 |
| 1978-08-16 | vs CIN | 116 | W 13-2 | 54-62 | 4 | 15,490 | John Candelaria | Bill Bonham | John Candelaria | Bill Bonham | Grant Jackson | 455 | 483 | -28 |
| 1978-08-17 | vs HOU | 117 | W 5-1 | 56-62 | 4 | 0 | Don Robinson | J.R. Richard | Don Robinson | J.R. Richard | | 460 | 484 | -24 |
| 1978-08-17 | vs HOU | 118 | W 3-2 | 56-62 | 4 | 8,470 | Bruce Kison | Mark Lemongello | Bruce Kison | Mark Lemongello | Kent Tekulve | 463 | 486 | -23 |
| 1978-08-18 | vs HOU | 119 | W 6-3 | 57-62 | 3 | 8,632 | Jim Bibby | Vern Ruhle | Jim Bibby | Vern Ruhle | Kent Tekulve | 469 | 489 | -20 |
| 1978-08-19 | vs HOU | 120 | W 4-2 | 58-62 | 3 | 22,015 | Bert Blyleven | Floyd Bannister | Bert Blyleven | Floyd Bannister | Kent Tekulve | 473 | 491 | -18 |
| 1978-08-20 | vs HOU | 121 | W 7-6 | 60-62 | 3 | 0 | Jim Rooker | Tom Dixon | Jim Rooker | Tom Dixon | Kent Tekulve | 480 | 497 | -17 |
| 1978-08-20 | vs HOU | 122 | W 3-1 | 60-62 | 3 | 21,851 | Jerry Reuss | Joe Niekro | Jerry Reuss | Joe Niekro | | 483 | 498 | -15 |
| 1978-08-22 | @ ATL | 123 | W 3-1 | 61-62 | 3 | 9,348 | Don Robinson | Mickey Mahler | Don Robinson | Mickey Mahler | Kent Tekulve | 486 | 499 | -13 |
| 1978-08-23 | @ ATL | 124 | W 4-3 | 62-62 | 3 | 6,553 | John Candelaria | Eddie Solomon | Grant Jackson | Dave Campbell | | 490 | 502 | -12 |
| 1978-08-24 | @ ATL | 125 | W 5-1 | 63-62 | 3 | 7,965 | Bert Blyleven | Phil Niekro | Bert Blyleven | Phil Niekro | Kent Tekulve | 495 | 503 | -8 |
| 1978-08-25 | @ HOU | 126 | L 5-7 | 63-63 | 3 | 11,641 | Jim Rooker | Joe Niekro | Joe Niekro | Jim Rooker | Joaquin Andujar | 500 | 510 | -10 |
| 1978-08-26 | @ HOU | 127 | L 2-7 | 63-64 | 3 | 9,985 | Bruce Kison | J.R. Richard | J.R. Richard | Bruce Kison | | 502 | 517 | -15 |
| 1978-08-27 | @ HOU | 128 | W 8-5 | 64-64 | 3 | 10,947 | Don Robinson | Mark Lemongello | Grant Jackson | Mark Lemongello | Kent Tekulve | 510 | 522 | -12 |
| 1978-08-28 | @ CIN | 129 | W 3-1 | 65-64 | 3 | 23,612 | John Candelaria | Fred Norman | John Candelaria | Fred Norman | Ed Whitson | 513 | 523 | -10 |
| 1978-08-29 | @ CIN | 130 | W 5-0 | 66-64 | 3 | 24,967 | Bert Blyleven | Mike LaCoss | Bert Blyleven | Mike LaCoss | | 518 | 523 | -5 |
| 1978-09-01 | vs ATL | 131 | W 8-3 | 68-64 | 2 | 0 | Don Robinson | Phil Niekro | Don Robinson | Phil Niekro | Kent Tekulve | 526 | 526 | 0 |
| 1978-09-01 | vs ATL | 132 | W 3-0 | 68-64 | 2 | 14,306 | Bruce Kison | Mickey Mahler | Bruce Kison | Mickey Mahler | Kent Tekulve | 529 | 526 | 3 |
| 1978-09-02 | vs ATL | 133 | W 4-3 | 69-64 | 2 | 9,580 | John Candelaria | Preston Hanna | Grant Jackson | Rick Camp | | 533 | 529 | 4 |
| 1978-09-03 | vs ATL | 134 | W 6-3 | 70-64 | 2 | 8,594 | Bert Blyleven | Eddie Solomon | Kent Tekulve | Gene Garber | | 539 | 532 | 7 |
| 1978-09-04 | vs NYN | 135 | W 7-4 | 72-64 | 2 | 0 | Jim Rooker | Roy Lee Jackson | Ed Whitson | Skip Lockwood | Grant Jackson | 546 | 536 | 10 |
| 1978-09-04 | vs NYN | 136 | W 7-0 | 72-64 | 2 | 25,765 | Jim Bibby | Juan Berenguer | Jim Bibby | Juan Berenguer | | 553 | 536 | 17 |
| 1978-09-05 | vs NYN | 137 | W 8-0 | 73-64 | 2 | 18,476 | Jerry Reuss | Jerry Koosman | Jerry Reuss | Jerry Koosman | | 561 | 536 | 25 |
| 1978-09-06 | @ SLN | 138 | W 4-1 | 74-64 | 2 | 7,945 | Don Robinson | John Denny | Don Robinson | John Denny | | 565 | 537 | 28 |
| 1978-09-07 | @ SLN | 139 | L 4-5 | 74-65 | 2 | 7,805 | Bruce Kison | Pete Falcone | Aurelio Lopez | Grant Jackson | Mark Littell | 569 | 542 | 27 |
| 1978-09-08 | @ NYN | 140 | L 2-3 | 74-66 | 2 | 4,749 | Bert Blyleven | Tom Hausman | Dale Murray | Bert Blyleven | | 571 | 545 | 26 |
| 1978-09-09 | @ NYN | 141 | L 1-4 | 74-67 | 2 | 8,881 | Jim Rooker | Kevin Kobel | Kevin Kobel | Jim Rooker | | 572 | 549 | 23 |
| 1978-09-10 | @ NYN | 142 | L 9-11 | 74-68 | 2 | 9,256 | Jerry Reuss | Jerry Koosman | Dwight Bernard | Kent Tekulve | Mardie Cornejo | 581 | 560 | 21 |
| 1978-09-11 | @ PHI | 143 | L 3-10 | 74-69 | 2 | 33,198 | Don Robinson | Steve Carlton | Steve Carlton | Don Robinson | | 584 | 570 | 14 |
| 1978-09-12 | @ PHI | 144 | W 5-1 | 75-69 | 2 | 31,355 | John Candelaria | Larry Christenson | John Candelaria | Larry Christenson | Kent Tekulve | 589 | 571 | 18 |
| 1978-09-13 | vs SLN | 145 | W 7-1 | 76-69 | 2 | 6,398 | Bert Blyleven | Pete Falcone | Bert Blyleven | Pete Falcone | | 596 | 572 | 24 |
| 1978-09-14 | vs SLN | 146 | W 7-4 | 77-69 | 2 | 5,294 | Jim Rooker | Bob Forsch | Jim Rooker | Bob Forsch | | 603 | 576 | 27 |
| 1978-09-15 | vs MON | 147 | W 6-1 | 78-69 | 2 | 15,146 | Bruce Kison | Woodie Fryman | Bruce Kison | Woodie Fryman | | 609 | 577 | 32 |
| 1978-09-16 | vs MON | 148 | W 12-5 | 79-69 | 2 | 8,079 | Don Robinson | Ross Grimsley | Don Robinson | Ross Grimsley | | 621 | 582 | 39 |
| 1978-09-17 | vs MON | 149 | W 5-3 | 80-69 | 2 | 8,544 | Bert Blyleven | Rudy May | Bert Blyleven | Rudy May | Kent Tekulve | 626 | 585 | 41 |
| 1978-09-19 | @ CHN | 150 | W 12-11 | 81-69 | 2 | 6,137 | John Candelaria | Rick Reuschel | Odell Jones | Bruce Sutter | | 638 | 596 | 42 |
| 1978-09-20 | @ CHN | 151 | L 1-5 | 81-70 | 2 | 5,269 | Jim Rooker | Mike Krukow | Mike Krukow | Jim Rooker | | 639 | 601 | 38 |
| 1978-09-21 | @ CHN | 152 | W 3-2 | 82-70 | 2 | 2,423 | Don Robinson | Dennis Lamp | Ed Whitson | Bruce Sutter | Jim Bibby | 642 | 603 | 39 |
| 1978-09-23 | @ MON | 153 | L 2-3 | 82-71 | 2 | 20,324 | Bert Blyleven | Ross Grimsley | Ross Grimsley | Bert Blyleven | | 644 | 606 | 38 |
| 1978-09-24 | @ MON | 154 | L 0-4 | 82-72 | 2 | 23,260 | Bruce Kison | Scott Sanderson | Scott Sanderson | Bruce Kison | | 644 | 610 | 34 |
| 1978-09-25 | vs CHN | 155 | W 7-4 | 83-72 | 2 | 5,937 | John Candelaria | Mike Krukow | John Candelaria | Mike Krukow | | 651 | 614 | 37 |
| 1978-09-26 | vs CHN | 156 | W 5-2 | 84-72 | 2 | 6,515 | Don Robinson | Dennis Lamp | Don Robinson | Dennis Lamp | | 656 | 616 | 40 |
| 1978-09-27 | vs CHN | 157 | W 8-3 | 85-72 | 2 | 7,467 | Jerry Reuss | Ray Burris | Jerry Reuss | Ray Burris | | 664 | 619 | 45 |
| 1978-09-29 | vs PHI | 158 | W 5-4 | 87-72 | 2 | 0 | Bert Blyleven | Dick Ruthven | Kent Tekulve | Ron Reed | | 669 | 623 | 46 |
| 1978-09-29 | vs PHI | 159 | W 2-1 | 87-72 | 2 | 45,134 | Bruce Kison | Steve Carlton | Kent Tekulve | Steve Carlton | | 671 | 624 | 47 |
| 1978-09-30 | vs PHI | 160 | L 8-10 | 87-73 | 2 | 28,905 | Don Robinson | Randy Lerch | Randy Lerch | Grant Jackson | Ron Reed | 679 | 634 | 45 |
| 1978-10-01 | vs PHI | 161 | W 5-3 | 88-73 | 2 | 30,224 | Odell Jones | Jim Kaat | Odell Jones | Kevin Saucier | Kent Tekulve | 684 | 637 | 47 |