| 1978-04-07 | @ CAL | 1 | L 0-1 | 0-1 | 6 | 28,194 | Rick Langford | Frank Tanana | Frank Tanana | Rick Langford | | 0 | 1 | -1 |
| 1978-04-08 | @ CAL | 2 | W 4-2 | 1-1 | 4 | 18,131 | Matt Keough | Nolan Ryan | Bob Lacey | Paul Hartzell | Dave Heaverlo | 4 | 3 | 1 |
| 1978-04-09 | @ CAL | 3 | L 2-3 | 1-2 | 7 | 15,975 | Alan Wirth | Chris Knapp | Chris Knapp | Alan Wirth | Dave LaRoche | 6 | 6 | 0 |
| 1978-04-10 | vs SEA | 4 | W 1-0 | 2-2 | 6 | 17,283 | John Henry Johnson | Glenn Abbott | John Henry Johnson | Glenn Abbott | Dave Heaverlo | 7 | 6 | 1 |
| 1978-04-11 | vs SEA | 5 | W 2-0 | 3-2 | 3 | 1,890 | Pete Broberg | Dick Pole | Pete Broberg | Dick Pole | Elias Sosa | 9 | 6 | 3 |
| 1978-04-12 | vs SEA | 6 | W 4-3 | 4-2 | 3 | 1,742 | Rick Langford | Rick Honeycutt | Dave Heaverlo | Shane Rawley | | 13 | 9 | 4 |
| 1978-04-13 | vs SEA | 7 | W 3-1 | 5-2 | 2 | 2,034 | Matt Keough | Paul Mitchell | Bob Lacey | Steve Burke | | 16 | 10 | 6 |
| 1978-04-14 | vs CAL | 8 | W 2-1 | 6-2 | 2 | 2,973 | Alan Wirth | Chris Knapp | Dave Heaverlo | Chris Knapp | | 18 | 11 | 7 |
| 1978-04-16 | vs CAL | 9 | L 1-2 | 6-3 | 2 | 3,814 | John Henry Johnson | Don Aase | Dave LaRoche | Dave Heaverlo | Paul Hartzell | 19 | 13 | 6 |
| 1978-04-17 | @ MIN | 10 | W 7-2 | 7-3 | 2 | 2,054 | Pete Broberg | Paul Thormodsgard | Pete Broberg | Paul Thormodsgard | | 26 | 15 | 11 |
| 1978-04-19 | @ MIN | 11 | W 6-5 | 8-3 | 2 | 1,935 | Rick Langford | Geoff Zahn | Elias Sosa | Tom Johnson | | 32 | 20 | 12 |
| 1978-04-21 | @ SEA | 12 | W 5-3 | 9-3 | 2 | 7,939 | Matt Keough | Dick Pole | Matt Keough | Dick Pole | Elias Sosa | 37 | 23 | 14 |
| 1978-04-22 | @ SEA | 13 | W 3-0 | 10-3 | 2 | 23,756 | Alan Wirth | Rick Honeycutt | Alan Wirth | Rick Honeycutt | Elias Sosa | 40 | 23 | 17 |
| 1978-04-23 | @ SEA | 14 | W 5-0 | 11-3 | 2 | 5,688 | John Henry Johnson | Paul Mitchell | John Henry Johnson | Paul Mitchell | | 45 | 23 | 22 |
| 1978-04-25 | vs MIN | 15 | W 5-3 | 13-3 | 1 | 0 | Pete Broberg | Paul Thormodsgard | Elias Sosa | Greg Thayer | | 50 | 26 | 24 |
| 1978-04-25 | vs MIN | 16 | W 4-3 | 13-3 | 1 | 4,808 | Rick Langford | Geoff Zahn | Joe Coleman | Tom Johnson | | 54 | 29 | 25 |
| 1978-04-26 | vs MIN | 17 | W 9-8 | 14-3 | 1 | 4,127 | Matt Keough | Roger Erickson | Joe Coleman | Tom Johnson | | 63 | 37 | 26 |
| 1978-04-27 | vs MIN | 18 | L 1-6 | 14-4 | 1 | 4,645 | Alan Wirth | Gary Serum | Gary Serum | Alan Wirth | | 64 | 43 | 21 |
| 1978-04-28 | vs CLE | 19 | L 2-6 | 14-5 | 1 | 5,513 | John Henry Johnson | Don Hood | Don Hood | John Henry Johnson | | 66 | 49 | 17 |
| 1978-04-29 | vs CLE | 20 | W 5-1 | 15-5 | 1 | 5,692 | Pete Broberg | Wayne Garland | Pete Broberg | Wayne Garland | Bob Lacey | 71 | 50 | 21 |
| 1978-04-30 | vs CLE | 21 | W 2-1 | 16-5 | 1 | 6,378 | Rick Langford | Rick Wise | Elias Sosa | Rick Wise | | 73 | 51 | 22 |
| 1978-05-02 | vs TOR | 22 | W 2-1 | 17-5 | 1 | 5,663 | Matt Keough | Tom Underwood | Matt Keough | Tom Underwood | Elias Sosa | 75 | 52 | 23 |
| 1978-05-03 | vs TOR | 23 | W 11-3 | 18-5 | 1 | 2,512 | Pete Broberg | Jim Clancy | Pete Broberg | Jim Clancy | Bob Lacey | 86 | 55 | 31 |
| 1978-05-05 | vs DET | 24 | W 5-1 | 19-5 | 1 | 14,612 | John Henry Johnson | Jack Billingham | John Henry Johnson | Jack Billingham | | 91 | 56 | 35 |
| 1978-05-06 | vs DET | 25 | L 0-6 | 19-6 | 1 | 12,539 | Alan Wirth | Bob Sykes | Bob Sykes | Alan Wirth | | 91 | 62 | 29 |
| 1978-05-07 | vs DET | 26 | L 0-4 | 19-7 | 1 | 16,239 | Matt Keough | Milt Wilcox | Milt Wilcox | Matt Keough | | 91 | 66 | 25 |
| 1978-05-09 | @ TOR | 27 | L 0-4 | 19-8 | 1 | 11,339 | Pete Broberg | Tom Underwood | Tom Underwood | Pete Broberg | | 91 | 70 | 21 |
| 1978-05-10 | @ TOR | 28 | L 1-3 | 19-9 | 1 | 21,766 | Rick Langford | Jim Clancy | Jim Clancy | Rick Langford | | 92 | 73 | 19 |
| 1978-05-12 | @ DET | 29 | W 10-4 | 20-9 | 1 | 18,367 | John Henry Johnson | Jack Billingham | Elias Sosa | John Hiller | | 102 | 77 | 25 |
| 1978-05-13 | @ DET | 30 | W 3-2 | 21-9 | 1 | 16,324 | Matt Keough | Dave Rozema | Bob Lacey | Dave Rozema | Elias Sosa | 105 | 79 | 26 |
| 1978-05-14 | @ DET | 31 | L 0-15 | 21-10 | 1 | 12,513 | Pete Broberg | Bob Sykes | Bob Sykes | Pete Broberg | | 105 | 94 | 11 |
| 1978-05-15 | @ CLE | 32 | W 3-2 | 22-10 | 1 | 3,454 | Alan Wirth | Rick Wise | Joe Coleman | Rick Wise | Elias Sosa | 108 | 96 | 12 |
| 1978-05-16 | @ CLE | 33 | L 2-3 | 22-11 | 1 | 3,737 | Steve Renko | David Clyde | David Clyde | Bob Lacey | | 110 | 99 | 11 |
| 1978-05-17 | @ TEX | 34 | L 3-4 | 22-12 | 1 | 15,635 | John Henry Johnson | Jon Matlack | Jon Matlack | John Henry Johnson | | 113 | 103 | 10 |
| 1978-05-18 | @ TEX | 35 | L 4-6 | 22-13 | 1 | 21,257 | Matt Keough | Jim Umbarger | Jim Umbarger | Matt Keough | Reggie Cleveland | 117 | 109 | 8 |
| 1978-05-19 | vs CHA | 36 | L 2-6 | 22-14 | 1 | 5,515 | Pete Broberg | Wilbur Wood | Wilbur Wood | Pete Broberg | | 119 | 115 | 4 |
| 1978-05-20 | vs CHA | 37 | W 4-3 | 23-14 | 1 | 4,177 | Alan Wirth | Ken Kravec | Rick Langford | Lerrin LaGrow | | 123 | 118 | 5 |
| 1978-05-21 | vs CHA | 38 | L 2-6 | 24-15 | 1 | 0 | Steve Renko | Steve Stone | Steve Stone | Bob Lacey | Jim Willoughby | 125 | 124 | 1 |
| 1978-05-21 | vs CHA | 39 | W 8-0 | 24-15 | 1 | 8,426 | John Henry Johnson | Francisco Barrios | John Henry Johnson | Francisco Barrios | | 133 | 124 | 9 |
| 1978-05-23 | vs MIL | 40 | L 2-3 | 24-16 | 1 | 2,534 | Matt Keough | Jerry Augustine | Jerry Augustine | Matt Keough | | 135 | 127 | 8 |
| 1978-05-24 | vs MIL | 41 | L 1-7 | 24-17 | 2 | 2,257 | Pete Broberg | Mike Caldwell | Mike Caldwell | Pete Broberg | | 136 | 134 | 2 |
| 1978-05-26 | @ CHA | 42 | W 3-1 | 25-17 | 2 | 19,018 | Alan Wirth | Steve Stone | Alan Wirth | Steve Stone | Bob Lacey | 139 | 135 | 4 |
| 1978-05-27 | @ CHA | 43 | W 4-3 | 26-17 | 1 | 28,367 | John Henry Johnson | Wilbur Wood | Bob Lacey | Jim Willoughby | | 143 | 138 | 5 |
| 1978-05-28 | @ CHA | 44 | L 2-3 | 26-19 | 2 | 0 | Matt Keough | Ken Kravec | Ken Kravec | Matt Keough | Jim Willoughby | 145 | 141 | 4 |
| 1978-05-28 | @ CHA | 45 | L 0-4 | 26-19 | 2 | 23,934 | Steve Renko | Francisco Barrios | Francisco Barrios | Steve Renko | | 145 | 145 | 0 |
| 1978-05-29 | @ MIL | 46 | W 6-2 | 27-19 | 1 | 18,665 | Pete Broberg | Jerry Augustine | Pete Broberg | Jerry Augustine | | 151 | 147 | 4 |
| 1978-05-30 | @ MIL | 47 | L 1-2 | 27-20 | 1 | 8,322 | Alan Wirth | Mike Caldwell | Mike Caldwell | Elias Sosa | | 152 | 149 | 3 |
| 1978-06-02 | vs NYA | 48 | L 1-3 | 27-21 | 2 | 18,993 | John Henry Johnson | Ron Guidry | Ron Guidry | John Henry Johnson | Rich Gossage | 153 | 152 | 1 |
| 1978-06-03 | vs NYA | 49 | W 5-1 | 28-21 | 1 | 14,499 | Matt Keough | Andy Messersmith | Matt Keough | Andy Messersmith | | 158 | 153 | 5 |
| 1978-06-04 | vs NYA | 50 | W 6-4 | 29-21 | 1 | 19,289 | John Henry Johnson | Don Gullett | Bob Lacey | Rawly Eastwick | Elias Sosa | 164 | 157 | 7 |
| 1978-06-05 | vs BOS | 51 | W 9-7 | 30-21 | 1 | 36,463 | Pete Broberg | Allen Ripley | Pete Broberg | Allen Ripley | Elias Sosa | 173 | 164 | 9 |
| 1978-06-06 | vs BOS | 52 | W 7-1 | 31-21 | 1 | 7,914 | Steve Renko | Bill Lee | Steve Renko | Bill Lee | | 180 | 165 | 15 |
| 1978-06-07 | vs CAL | 53 | L 1-4 | 32-22 | 1 | 0 | Alan Wirth | Ken Brett | Ken Brett | Alan Wirth | | 181 | 169 | 12 |
| 1978-06-07 | vs CAL | 54 | W 1-0 | 32-22 | 1 | 6,560 | Matt Keough | Tom Griffin | Matt Keough | Tom Griffin | Elias Sosa | 182 | 169 | 13 |
| 1978-06-08 | vs CAL | 55 | L 7-10 | 32-23 | 1 | 2,612 | John Henry Johnson | Chris Knapp | Dave LaRoche | Elias Sosa | | 189 | 179 | 10 |
| 1978-06-09 | vs BAL | 56 | L 3-5 | 32-24 | 1 | 3,323 | Pete Broberg | Mike Flanagan | Mike Flanagan | Pete Broberg | | 192 | 184 | 8 |
| 1978-06-10 | vs BAL | 57 | L 0-1 | 32-25 | 1 | 11,422 | Steve Renko | Jim Palmer | Jim Palmer | Steve Renko | | 192 | 185 | 7 |
| 1978-06-11 | vs BAL | 58 | L 0-3 | 32-26 | 1 | 17,157 | Mike Morgan | Scott McGregor | Scott McGregor | Mike Morgan | | 192 | 188 | 4 |
| 1978-06-12 | @ NYA | 59 | L 0-2 | 32-27 | 1 | 28,457 | Matt Keough | Ron Guidry | Ron Guidry | Dave Heaverlo | | 192 | 190 | 2 |
| 1978-06-13 | @ NYA | 60 | L 3-5 | 32-28 | 1 | 30,779 | John Henry Johnson | Ed Figueroa | Ed Figueroa | Rick Langford | Rich Gossage | 195 | 195 | 0 |
| 1978-06-14 | @ BOS | 61 | L 0-9 | 32-29 | 2 | 29,690 | Pete Broberg | Luis Tiant | Luis Tiant | Pete Broberg | | 195 | 204 | -9 |
| 1978-06-15 | @ BOS | 62 | L 3-7 | 32-30 | 2 | 32,281 | Steve Renko | Mike Torrez | Mike Torrez | Bob Lacey | | 198 | 211 | -13 |
| 1978-06-16 | @ BAL | 63 | L 0-6 | 32-31 | 3 | 31,944 | Rick Langford | Dennis Martinez | Dennis Martinez | Rick Langford | | 198 | 217 | -19 |
| 1978-06-17 | @ BAL | 64 | L 4-5 | 32-32 | 3 | 24,619 | Mike Morgan | Mike Flanagan | Mike Flanagan | Mike Morgan | Don Stanhouse | 202 | 222 | -20 |
| 1978-06-18 | @ BAL | 65 | L 1-2 | 32-33 | 4 | 17,143 | John Henry Johnson | Jim Palmer | Jim Palmer | John Henry Johnson | Tippy Martinez | 203 | 224 | -21 |
| 1978-06-19 | @ TEX | 66 | W 2-1 | 33-33 | 3 | 17,029 | Steve Renko | Jon Matlack | Steve Renko | Jon Matlack | Elias Sosa | 205 | 225 | -20 |
| 1978-06-20 | @ TEX | 67 | L 4-5 | 33-34 | 4 | 17,394 | Matt Keough | Doc Medich | Jim Umbarger | Dave Heaverlo | | 209 | 230 | -21 |
| 1978-06-22 | @ TEX | 68 | L 2-8 | 33-35 | 4 | 20,599 | Mike Morgan | Dock Ellis | Dock Ellis | Mike Morgan | | 211 | 238 | -27 |
| 1978-06-23 | @ KCA | 69 | L 3-5 | 34-36 | 4 | 0 | Rick Langford | Paul Splittorff | Paul Splittorff | Rick Langford | Al Hrabosky | 214 | 243 | -29 |
| 1978-06-23 | @ KCA | 70 | W 5-4 | 34-36 | 4 | 38,841 | Tim Conroy | Dennis Leonard | Pete Broberg | Dennis Leonard | Dave Heaverlo | 219 | 247 | -28 |
| 1978-06-24 | @ KCA | 71 | L 5-7 | 34-37 | 4 | 35,423 | Steve Renko | Andy Hassler | Andy Hassler | Steve Renko | Al Hrabosky | 224 | 254 | -30 |
| 1978-06-25 | @ KCA | 72 | W 6-3 | 35-37 | 4 | 32,842 | Matt Keough | Larry Gura | Bob Lacey | Larry Gura | Elias Sosa | 230 | 257 | -27 |
| 1978-06-27 | vs TEX | 73 | L 1-3 | 35-38 | 4 | 3,619 | Rick Langford | Dock Ellis | Dock Ellis | Rick Langford | Reggie Cleveland | 231 | 260 | -29 |
| 1978-06-28 | vs TEX | 74 | W 2-1 | 36-38 | 4 | 2,346 | Steve Renko | Doyle Alexander | Pete Broberg | Len Barker | | 233 | 261 | -28 |
| 1978-06-29 | vs TEX | 75 | W 8-7 | 37-38 | 4 | 3,380 | Tim Conroy | Fergie Jenkins | Dave Heaverlo | Paul Lindblad | | 241 | 268 | -27 |
| 1978-06-30 | vs KCA | 76 | W 2-1 | 38-38 | 4 | 16,506 | Matt Keough | Rich Gale | Matt Keough | Rich Gale | | 243 | 269 | -26 |
| 1978-07-01 | vs KCA | 77 | W 4-2 | 39-38 | 4 | 5,062 | John Henry Johnson | Dennis Leonard | John Henry Johnson | Dennis Leonard | | 247 | 271 | -24 |
| 1978-07-02 | vs KCA | 78 | L 2-4 | 40-39 | 4 | 0 | Rick Langford | Larry Gura | Larry Gura | Bob Lacey | Al Hrabosky | 249 | 275 | -26 |
| 1978-07-02 | vs KCA | 79 | W 9-3 | 40-39 | 4 | 13,486 | Steve Renko | Andy Hassler | Steve Renko | Andy Hassler | | 258 | 278 | -20 |
| 1978-07-03 | @ SEA | 80 | W 5-3 | 41-39 | 3 | 9,489 | Pete Broberg | Glenn Abbott | Pete Broberg | Glenn Abbott | Dave Heaverlo | 263 | 281 | -18 |
| 1978-07-04 | @ SEA | 81 | W 9-4 | 42-39 | 2 | 10,942 | Craig Minetto | Rick Honeycutt | Elias Sosa | Rick Honeycutt | | 272 | 285 | -13 |
| 1978-07-05 | @ SEA | 82 | W 5-3 | 43-39 | 1 | 6,723 | Matt Keough | Mike Parrott | Matt Keough | Shane Rawley | Dave Heaverlo | 277 | 288 | -11 |
| 1978-07-06 | @ SEA | 83 | L 2-3 | 43-40 | 2 | 7,523 | John Henry Johnson | Paul Mitchell | Paul Mitchell | John Henry Johnson | Enrique Romo | 279 | 291 | -12 |
| 1978-07-07 | vs MIN | 84 | L 2-3 | 43-42 | 4 | 0 | Steve Renko | Geoff Zahn | Geoff Zahn | Steve Renko | Mike Marshall | 281 | 294 | -13 |
| 1978-07-07 | vs MIN | 85 | L 0-1 | 43-42 | 4 | 7,239 | Rick Langford | Darrell Jackson | Darrell Jackson | Rick Langford | | 281 | 295 | -14 |
| 1978-07-08 | vs MIN | 86 | L 8-9 | 43-43 | 3 | 12,201 | Pete Broberg | Roger Erickson | Mike Marshall | Dave Heaverlo | | 289 | 304 | -15 |
| 1978-07-09 | vs MIN | 87 | L 0-7 | 43-44 | 4 | 4,720 | Pete Broberg | Dave Goltz | Dave Goltz | Pete Broberg | | 289 | 311 | -22 |
| 1978-07-13 | vs CLE | 88 | W 7-3 | 44-44 | 4 | 2,987 | John Henry Johnson | Rick Waits | John Henry Johnson | Rick Waits | Dave Heaverlo | 296 | 314 | -18 |
| 1978-07-14 | vs CLE | 89 | L 1-11 | 44-45 | 4 | 3,326 | Matt Keough | Rick Wise | Rick Wise | Matt Keough | | 297 | 325 | -28 |
| 1978-07-15 | vs TOR | 90 | W 3-2 | 45-45 | 4 | 6,863 | Steve Renko | Tom Underwood | Elias Sosa | Tom Underwood | | 300 | 327 | -27 |
| 1978-07-16 | vs TOR | 91 | W 8-5 | 46-45 | 4 | 3,753 | Pete Broberg | Jim Clancy | Elias Sosa | Mike Willis | Dave Heaverlo | 308 | 332 | -24 |
| 1978-07-17 | vs TOR | 92 | W 5-3 | 47-45 | 4 | 12,414 | John Henry Johnson | Jerry Garvin | John Henry Johnson | Jerry Garvin | | 313 | 335 | -22 |
| 1978-07-18 | vs DET | 93 | W 6-3 | 48-45 | 3 | 3,023 | Rick Langford | Dave Rozema | Rick Langford | Dave Rozema | Bob Lacey | 319 | 338 | -19 |
| 1978-07-19 | vs DET | 94 | L 4-5 | 48-46 | 3 | 5,225 | Matt Keough | Jim Slaton | Jim Slaton | Matt Keough | | 323 | 343 | -20 |
| 1978-07-21 | @ TOR | 95 | W 7-2 | 49-47 | 3 | 0 | Steve Renko | Balor Moore | Steve Renko | Balor Moore | | 330 | 345 | -15 |
| 1978-07-21 | @ TOR | 96 | L 4-5 | 49-47 | 3 | 21,050 | Pete Broberg | Tom Underwood | Tom Murphy | Bob Lacey | Victor Cruz | 334 | 350 | -16 |
| 1978-07-22 | @ TOR | 97 | L 3-7 | 49-48 | 3 | 21,028 | John Henry Johnson | Jim Clancy | Jim Clancy | John Henry Johnson | | 337 | 357 | -20 |
| 1978-07-23 | @ TOR | 98 | W 5-3 | 50-48 | 3 | 23,153 | Rick Langford | Jerry Garvin | Rick Langford | Jerry Garvin | Dave Heaverlo | 342 | 360 | -18 |
| 1978-07-24 | @ DET | 99 | L 1-4 | 50-49 | 3 | 19,733 | Matt Keough | Kip Young | Kip Young | Matt Keough | | 343 | 364 | -21 |
| 1978-07-25 | @ DET | 100 | L 2-11 | 50-50 | 3 | 17,723 | Steve Renko | Milt Wilcox | Milt Wilcox | Steve Renko | | 345 | 375 | -30 |
| 1978-07-26 | @ CHA | 101 | W 8-4 | 51-50 | 3 | 11,897 | John Henry Johnson | Wilbur Wood | John Henry Johnson | Wilbur Wood | Elias Sosa | 353 | 379 | -26 |
| 1978-07-27 | @ CHA | 102 | W 7-4 | 52-50 | 3 | 19,632 | Rick Langford | Ken Kravec | Bob Lacey | Ken Kravec | Elias Sosa | 360 | 383 | -23 |
| 1978-07-28 | @ CLE | 103 | L 2-4 | 52-51 | 3 | 8,032 | Pete Broberg | Dave Freisleben | Jim Kern | Pete Broberg | | 362 | 387 | -25 |
| 1978-07-29 | @ CLE | 104 | W 6-5 | 53-51 | 3 | 17,828 | Steve Renko | Rick Wise | Steve Renko | Rick Wise | Dave Heaverlo | 368 | 392 | -24 |
| 1978-07-30 | @ CLE | 105 | W 5-4 | 54-51 | 3 | 10,272 | John Henry Johnson | Mike Paxton | Elias Sosa | Jim Kern | | 373 | 396 | -23 |
| 1978-07-31 | @ CAL | 106 | W 2-0 | 55-51 | 3 | 29,044 | Matt Keough | Frank Tanana | Matt Keough | Frank Tanana | Elias Sosa | 375 | 396 | -21 |
| 1978-08-01 | @ CAL | 107 | W 1-0 | 56-51 | 2 | 19,485 | Rick Langford | Nolan Ryan | Rick Langford | Nolan Ryan | | 376 | 396 | -20 |
| 1978-08-02 | @ CAL | 108 | L 2-8 | 56-52 | 3 | 16,898 | Pete Broberg | Don Aase | Don Aase | Pete Broberg | | 378 | 404 | -26 |
| 1978-08-03 | @ CAL | 109 | L 1-8 | 56-53 | 3 | 15,792 | Steve Renko | Paul Hartzell | Paul Hartzell | Steve Renko | | 379 | 412 | -33 |
| 1978-08-04 | vs SEA | 110 | W 6-1 | 57-53 | 3 | 2,502 | John Henry Johnson | Glenn Abbott | John Henry Johnson | Glenn Abbott | | 385 | 413 | -28 |
| 1978-08-05 | vs SEA | 111 | L 2-3 | 57-54 | 3 | 2,677 | Matt Keough | Byron McLaughlin | Jim Todd | Matt Keough | | 387 | 416 | -29 |
| 1978-08-06 | vs SEA | 112 | W 4-3 | 59-54 | 3 | 0 | Rick Langford | Paul Mitchell | Rick Langford | Shane Rawley | | 391 | 419 | -28 |
| 1978-08-06 | vs SEA | 113 | W 4-3 | 59-54 | 3 | 4,898 | Pete Broberg | Tom House | Bob Lacey | Enrique Romo | | 395 | 422 | -27 |
| 1978-08-07 | vs CAL | 114 | W 1-0 | 60-54 | 3 | 17,183 | Steve Renko | Don Aase | Steve Renko | Don Aase | | 396 | 422 | -26 |
| 1978-08-08 | vs CAL | 115 | L 1-2 | 60-55 | 3 | 4,624 | John Henry Johnson | Paul Hartzell | Paul Hartzell | Dave Heaverlo | Dave LaRoche | 397 | 424 | -27 |
| 1978-08-10 | vs CAL | 116 | L 5-16 | 60-56 | 3 | 3,832 | Matt Keough | Frank Tanana | Frank Tanana | Matt Keough | | 402 | 440 | -38 |
| 1978-08-11 | @ MIN | 117 | W 2-0 | 61-57 | 3 | 0 | Rick Langford | Geoff Zahn | Rick Langford | Geoff Zahn | | 404 | 440 | -36 |
| 1978-08-11 | @ MIN | 118 | L 2-3 | 61-57 | 3 | 13,795 | Pete Broberg | Darrell Jackson | Darrell Jackson | Pete Broberg | Mike Marshall | 406 | 443 | -37 |
| 1978-08-12 | @ MIN | 119 | L 3-6 | 61-58 | 3 | 11,740 | Steve Renko | Stan Perzanowski | Stan Perzanowski | Steve Renko | Mike Marshall | 409 | 449 | -40 |
| 1978-08-13 | @ MIN | 120 | L 1-3 | 61-60 | 3 | 0 | Matt Keough | Gary Serum | Gary Serum | Matt Keough | | 410 | 452 | -42 |
| 1978-08-13 | @ MIN | 121 | L 1-2 | 61-60 | 3 | 18,577 | Mike Norris | Roger Erickson | Roger Erickson | Mike Norris | | 411 | 454 | -43 |
| 1978-08-15 | vs NYA | 122 | L 0-6 | 61-61 | 4 | 13,862 | Rick Langford | Ron Guidry | Ron Guidry | Rick Langford | | 411 | 460 | -49 |
| 1978-08-16 | vs NYA | 123 | L 3-5 | 61-62 | 4 | 10,394 | Pete Broberg | Catfish Hunter | Catfish Hunter | Bob Lacey | Rich Gossage | 414 | 465 | -51 |
| 1978-08-18 | vs BOS | 124 | L 3-6 | 61-63 | 4 | 12,730 | Steve Renko | Mike Torrez | Mike Torrez | Steve Renko | Dick Drago | 417 | 471 | -54 |
| 1978-08-19 | vs BOS | 125 | W 8-4 | 62-63 | 4 | 11,806 | John Henry Johnson | Bill Lee | John Henry Johnson | Bill Lee | Bob Lacey | 425 | 475 | -50 |
| 1978-08-20 | vs BOS | 126 | L 2-4 | 62-64 | 4 | 13,411 | Matt Keough | Dennis Eckersley | Dennis Eckersley | Matt Keough | | 427 | 479 | -52 |
| 1978-08-21 | vs BAL | 127 | L 2-3 | 62-65 | 4 | 9,786 | Rick Langford | Mike Flanagan | Mike Flanagan | Rick Langford | | 429 | 482 | -53 |
| 1978-08-22 | vs BAL | 128 | L 4-6 | 62-66 | 4 | 1,930 | Pete Broberg | Scott McGregor | Don Stanhouse | Bob Lacey | Joe Kerrigan | 433 | 488 | -55 |
| 1978-08-23 | vs BAL | 129 | L 0-11 | 62-67 | 4 | 2,497 | Steve Renko | Jim Palmer | Jim Palmer | Steve Renko | | 433 | 499 | -66 |
| 1978-08-25 | @ NYA | 130 | L 1-7 | 62-68 | 4 | 29,010 | John Henry Johnson | Ron Guidry | Ron Guidry | John Henry Johnson | | 434 | 506 | -72 |
| 1978-08-26 | @ NYA | 131 | L 4-5 | 62-69 | 4 | 53,883 | Matt Keough | Dick Tidrow | Sparky Lyle | Bob Lacey | | 438 | 511 | -73 |
| 1978-08-27 | @ NYA | 132 | L 2-6 | 62-70 | 4 | 40,628 | Rick Langford | Catfish Hunter | Catfish Hunter | Rick Langford | Rich Gossage | 440 | 517 | -77 |
| 1978-08-28 | @ BAL | 133 | L 3-7 | 62-71 | 4 | 6,000 | Steve Renko | Jim Palmer | Jim Palmer | Bob Lacey | | 443 | 524 | -81 |
| 1978-08-29 | @ BAL | 134 | L 2-6 | 62-72 | 4 | 4,995 | Mike Norris | Dennis Martinez | Dennis Martinez | Mike Norris | | 445 | 530 | -85 |
| 1978-09-01 | @ BOS | 135 | W 5-1 | 63-72 | 4 | 30,156 | Matt Keough | Luis Tiant | Matt Keough | Luis Tiant | | 450 | 531 | -81 |
| 1978-09-02 | @ BOS | 136 | W 4-3 | 64-72 | 4 | 33,051 | Rick Langford | Mike Torrez | Rick Langford | Mike Torrez | Dave Heaverlo | 454 | 534 | -80 |
| 1978-09-03 | @ BOS | 137 | L 6-11 | 64-73 | 4 | 29,029 | Steve Renko | Jim Wright | Bob Stanley | Pete Broberg | | 460 | 545 | -85 |
| 1978-09-04 | vs KCA | 138 | L 3-5 | 64-74 | 4 | 7,550 | Mike Norris | Rich Gale | Rich Gale | Mike Norris | Al Hrabosky | 463 | 550 | -87 |
| 1978-09-05 | vs KCA | 139 | L 0-3 | 64-75 | 4 | 1,376 | Steve Renko | Dennis Leonard | Dennis Leonard | Steve Renko | | 463 | 553 | -90 |
| 1978-09-06 | vs KCA | 140 | L 8-11 | 64-76 | 4 | 1,350 | Matt Keough | Paul Splittorff | Al Hrabosky | Dave Heaverlo | Marty Pattin | 471 | 564 | -93 |
| 1978-09-08 | vs TEX | 141 | W 11-4 | 65-76 | 4 | 9,841 | John Henry Johnson | Jon Matlack | Alan Wirth | Jon Matlack | | 482 | 568 | -86 |
| 1978-09-10 | vs TEX | 142 | L 3-8 | 66-77 | 4 | 0 | Mike Norris | Doyle Alexander | Doyle Alexander | Mike Norris | | 485 | 576 | -91 |
| 1978-09-10 | vs TEX | 143 | W 2-1 | 66-77 | 4 | 2,739 | Pete Broberg | Steve Comer | Pete Broberg | Steve Comer | | 487 | 577 | -90 |
| 1978-09-11 | @ KCA | 144 | L 2-7 | 66-78 | 4 | 24,765 | Matt Keough | Marty Pattin | Marty Pattin | Matt Keough | | 489 | 584 | -95 |
| 1978-09-12 | @ KCA | 145 | L 1-8 | 66-79 | 4 | 21,379 | Rick Langford | Larry Gura | Larry Gura | Rick Langford | | 490 | 592 | -102 |
| 1978-09-13 | @ KCA | 146 | L 1-9 | 66-80 | 4 | 18,359 | John Henry Johnson | Dennis Leonard | Dennis Leonard | John Henry Johnson | | 491 | 601 | -110 |
| 1978-09-14 | @ KCA | 147 | L 1-5 | 66-81 | 4 | 19,617 | Steve Renko | Paul Splittorff | Paul Splittorff | Steve Renko | | 492 | 606 | -114 |
| 1978-09-15 | @ TEX | 148 | W 1-0 | 67-82 | 4 | 0 | Alan Wirth | Doyle Alexander | Alan Wirth | Doyle Alexander | | 493 | 606 | -113 |
| 1978-09-15 | @ TEX | 149 | L 0-5 | 67-82 | 4 | 8,779 | Pete Broberg | Steve Comer | Steve Comer | Pete Broberg | | 493 | 611 | -118 |
| 1978-09-16 | @ TEX | 150 | L 1-8 | 67-83 | 5 | 14,948 | Matt Keough | Fergie Jenkins | Fergie Jenkins | Matt Keough | | 494 | 619 | -125 |
| 1978-09-17 | @ TEX | 151 | L 1-3 | 67-84 | 5 | 6,564 | Rick Langford | Jon Matlack | Jon Matlack | Rick Langford | | 495 | 622 | -127 |
| 1978-09-18 | vs CHA | 152 | W 6-3 | 68-84 | 5 | 3,657 | John Henry Johnson | Ken Kravec | John Henry Johnson | Ken Kravec | | 501 | 625 | -124 |
| 1978-09-19 | vs CHA | 153 | L 4-8 | 68-86 | 5 | 0 | Alan Wirth | Steve Stone | Steve Stone | Alan Wirth | | 505 | 633 | -128 |
| 1978-09-19 | vs CHA | 154 | L 3-7 | 68-86 | 5 | 1,740 | Steve Renko | Steve Trout | Steve Trout | Steve Renko | | 508 | 640 | -132 |
| 1978-09-22 | @ MIL | 155 | L 0-3 | 68-87 | 5 | 9,675 | Matt Keough | Eduardo Rodriguez | Eduardo Rodriguez | Matt Keough | Bill Castro | 508 | 643 | -135 |
| 1978-09-23 | @ MIL | 156 | L 4-13 | 68-88 | 6 | 14,450 | Mike Norris | Bill Travers | Bill Travers | Mike Norris | | 512 | 656 | -144 |
| 1978-09-24 | @ MIL | 157 | L 2-5 | 68-89 | 6 | 16,535 | Rick Langford | Mike Caldwell | Mike Caldwell | Rick Langford | | 514 | 661 | -147 |
| 1978-09-25 | @ CHA | 158 | L 2-6 | 68-90 | 6 | 5,279 | John Henry Johnson | Jack Kucek | Jack Kucek | John Henry Johnson | Lerrin LaGrow | 516 | 667 | -151 |
| 1978-09-26 | @ CHA | 159 | W 10-3 | 69-90 | 6 | 10,408 | Alan Wirth | Ken Kravec | Alan Wirth | Ken Kravec | | 526 | 670 | -144 |
| 1978-09-29 | vs MIL | 160 | L 1-3 | 69-91 | 6 | 1,992 | Matt Keough | Bill Travers | Bill Travers | Matt Keough | | 527 | 673 | -146 |
| 1978-09-30 | vs MIL | 161 | L 5-8 | 69-92 | 6 | 2,143 | John Henry Johnson | Mike Caldwell | Mike Caldwell | John Henry Johnson | Bill Castro | 532 | 681 | -149 |
| 1978-10-01 | vs MIL | 162 | L 0-9 | 69-93 | 6 | 2,742 | Alan Wirth | Lary Sorensen | Lary Sorensen | Alan Wirth | Moose Haas | 532 | 690 | -158 |