| 1978-04-08 | @ TEX | 1 | L 1-2 | 0-1 | 7 | 40,078 | Ron Guidry | Jon Matlack | Jon Matlack | Rich Gossage | | 1 | 2 | -1 |
| 1978-04-09 | @ TEX | 2 | W 7-1 | 1-1 | 4 | 20,243 | Ed Figueroa | Doyle Alexander | Ed Figueroa | Doyle Alexander | | 8 | 3 | 5 |
| 1978-04-10 | @ TEX | 3 | L 2-5 | 1-2 | 4 | 14,299 | Dick Tidrow | Dock Ellis | Dock Ellis | Dick Tidrow | Roger Moret | 10 | 8 | 2 |
| 1978-04-11 | @ MIL | 4 | L 6-9 | 1-3 | 5 | 8,934 | Catfish Hunter | Jerry Augustine | Jerry Augustine | Catfish Hunter | Mike Caldwell | 16 | 17 | -1 |
| 1978-04-12 | @ MIL | 5 | L 3-5 | 1-4 | 5 | 8,751 | Ken Holtzman | Moose Haas | Moose Haas | Rich Gossage | | 19 | 22 | -3 |
| 1978-04-13 | vs CHA | 6 | W 4-2 | 2-4 | 5 | 44,667 | Ron Guidry | Wilbur Wood | Ron Guidry | Wilbur Wood | | 23 | 24 | -1 |
| 1978-04-15 | vs CHA | 7 | W 3-2 | 3-4 | 4 | 20,965 | Ed Figueroa | Francisco Barrios | Ed Figueroa | Francisco Barrios | | 26 | 26 | 0 |
| 1978-04-16 | vs CHA | 8 | W 3-0 | 4-4 | 4 | 32,750 | Dick Tidrow | Ken Kravec | Dick Tidrow | Ken Kravec | Sparky Lyle | 29 | 26 | 3 |
| 1978-04-17 | vs BAL | 9 | L 1-6 | 4-5 | 4 | 15,674 | Catfish Hunter | Mike Flanagan | Mike Flanagan | Catfish Hunter | | 30 | 32 | -2 |
| 1978-04-18 | vs BAL | 10 | W 4-3 | 5-5 | 4 | 15,628 | Ron Guidry | Dennis Martinez | Sparky Lyle | Tippy Martinez | | 34 | 35 | -1 |
| 1978-04-19 | @ TOR | 11 | L 3-4 | 5-6 | 4 | 13,306 | Ken Holtzman | Jerry Garvin | Tom Murphy | Rich Gossage | | 37 | 39 | -2 |
| 1978-04-21 | vs MIL | 12 | L 2-9 | 5-7 | 5 | 15,105 | Ed Figueroa | Jerry Augustine | Jerry Augustine | Ed Figueroa | | 39 | 48 | -9 |
| 1978-04-22 | vs MIL | 13 | W 4-3 | 6-7 | 4 | 17,594 | Dick Tidrow | Mike Caldwell | Sparky Lyle | Bob McClure | | 43 | 51 | -8 |
| 1978-04-23 | vs MIL | 14 | L 2-3 | 6-8 | 4 | 26,291 | Catfish Hunter | Lary Sorensen | Lary Sorensen | Catfish Hunter | Bob McClure | 45 | 54 | -9 |
| 1978-04-24 | @ BAL | 15 | W 8-2 | 7-8 | 4 | 18,053 | Ron Guidry | Scott McGregor | Ron Guidry | Scott McGregor | | 53 | 56 | -3 |
| 1978-04-25 | @ BAL | 16 | W 4-3 | 8-8 | 5 | 14,159 | Jim Beattie | Jim Palmer | Jim Beattie | Jim Palmer | Sparky Lyle | 57 | 59 | -2 |
| 1978-04-28 | @ MIN | 17 | W 3-1 | 9-8 | 3 | 11,674 | Ed Figueroa | Paul Thormodsgard | Ed Figueroa | Paul Thormodsgard | | 60 | 60 | 0 |
| 1978-04-29 | @ MIN | 18 | L 1-3 | 9-9 | 3 | 10,543 | Dick Tidrow | Geoff Zahn | Geoff Zahn | Dick Tidrow | | 61 | 63 | -2 |
| 1978-04-30 | @ MIN | 19 | W 3-2 | 10-9 | 3 | 13,929 | Ron Guidry | Roger Erickson | Rich Gossage | Mac Scarce | | 64 | 65 | -1 |
| 1978-05-01 | vs KCA | 20 | W 8-4 | 11-9 | 3 | 17,340 | Jim Beattie | Paul Splittorff | Rawly Eastwick | Paul Splittorff | Sparky Lyle | 72 | 69 | 3 |
| 1978-05-02 | vs KCA | 21 | W 4-2 | 12-9 | 2 | 19,152 | Catfish Hunter | Larry Gura | Catfish Hunter | Larry Gura | Sparky Lyle | 76 | 71 | 5 |
| 1978-05-03 | vs KCA | 22 | W 6-5 | 13-9 | 2 | 21,230 | Ed Figueroa | Dennis Leonard | Ed Figueroa | Dennis Leonard | Rich Gossage | 82 | 76 | 6 |
| 1978-05-05 | vs TEX | 23 | W 5-2 | 14-9 | 2 | 17,285 | Ron Guidry | Jon Matlack | Ron Guidry | Jon Matlack | Rich Gossage | 87 | 78 | 9 |
| 1978-05-06 | vs TEX | 24 | L 5-9 | 14-10 | 3 | 19,788 | Dick Tidrow | Jim Umbarger | Jim Umbarger | Dick Tidrow | | 92 | 87 | 5 |
| 1978-05-07 | vs TEX | 25 | W 3-2 | 15-10 | 3 | 53,829 | Jim Beattie | Dock Ellis | Rich Gossage | Len Barker | | 95 | 89 | 6 |
| 1978-05-09 | vs MIN | 26 | W 3-1 | 16-10 | 3 | 11,271 | Catfish Hunter | Paul Thormodsgard | Catfish Hunter | Paul Thormodsgard | Sparky Lyle | 98 | 90 | 8 |
| 1978-05-12 | @ KCA | 27 | L 3-4 | 16-11 | 3 | 33,061 | Ed Figueroa | Paul Splittorff | Doug Bird | Rich Gossage | | 101 | 94 | 7 |
| 1978-05-13 | @ KCA | 28 | W 5-2 | 17-11 | 3 | 40,903 | Ron Guidry | Dennis Leonard | Ron Guidry | Dennis Leonard | Rich Gossage | 106 | 96 | 10 |
| 1978-05-14 | @ KCA | 29 | L 9-10 | 17-12 | 3 | 36,034 | Dick Tidrow | Andy Hassler | Al Hrabosky | Ken Clay | | 115 | 106 | 9 |
| 1978-05-15 | @ CHA | 30 | W 4-1 | 18-12 | 3 | 17,569 | Jim Beattie | Rich Wortham | Jim Beattie | Rich Wortham | Sparky Lyle | 119 | 107 | 12 |
| 1978-05-16 | @ CHA | 31 | W 8-3 | 19-12 | 3 | 21,837 | Ken Holtzman | Wilbur Wood | Ken Holtzman | Wilbur Wood | Rich Gossage | 127 | 110 | 17 |
| 1978-05-17 | @ CLE | 32 | L 4-5 | 19-13 | 3 | 10,370 | Ed Figueroa | Rick Waits | Sid Monge | Sparky Lyle | | 131 | 115 | 16 |
| 1978-05-18 | @ CLE | 33 | W 5-3 | 20-13 | 3 | 13,625 | Ron Guidry | Don Hood | Ron Guidry | Dennis Kinney | Rich Gossage | 136 | 118 | 18 |
| 1978-05-19 | @ TOR | 34 | W 11-3 | 21-13 | 3 | 26,025 | Dick Tidrow | Jesse Jefferson | Dick Tidrow | Jesse Jefferson | | 147 | 121 | 26 |
| 1978-05-20 | @ TOR | 35 | L 8-10 | 21-14 | 3 | 30,550 | Jim Beattie | Dave Lemanczyk | Dave Lemanczyk | Ken Clay | | 155 | 131 | 24 |
| 1978-05-21 | @ TOR | 36 | W 2-1 | 23-14 | 3 | 0 | Ed Figueroa | Tom Underwood | Ed Figueroa | Tom Underwood | Rich Gossage | 157 | 132 | 25 |
| 1978-05-21 | @ TOR | 37 | W 9-1 | 23-14 | 3 | 41,308 | Ken Clay | Jerry Garvin | Ken Clay | Jerry Garvin | | 166 | 133 | 33 |
| 1978-05-23 | vs CLE | 38 | W 10-1 | 24-14 | 3 | 20,618 | Ron Guidry | Don Hood | Ron Guidry | Don Hood | | 176 | 134 | 42 |
| 1978-05-25 | vs CLE | 39 | W 9-3 | 25-14 | 2 | 15,403 | Dick Tidrow | Rick Waits | Dick Tidrow | Rick Waits | | 185 | 137 | 48 |
| 1978-05-26 | vs TOR | 40 | W 4-3 | 26-14 | 2 | 24,171 | Jim Beattie | Jerry Garvin | Sparky Lyle | Jerry Garvin | | 189 | 140 | 49 |
| 1978-05-27 | vs TOR | 41 | L 1-4 | 26-15 | 2 | 56,078 | Ed Figueroa | Jim Clancy | Jim Clancy | Ed Figueroa | Tom Murphy | 190 | 144 | 46 |
| 1978-05-28 | vs TOR | 42 | W 5-3 | 28-15 | 2 | 41,534 | Ron Guidry | Jesse Jefferson | Ron Guidry | Jesse Jefferson | | 195 | 147 | 48 |
| 1978-05-28 | vs TOR | 43 | W 6-5 | 28-15 | 2 | 42,344 | Ken Clay | Dave Lemanczyk | Rich Gossage | Tom Murphy | | 201 | 152 | 49 |
| 1978-05-29 | @ CLE | 44 | W 2-0 | 29-15 | 2 | 19,563 | Andy Messersmith | Rick Waits | Rawly Eastwick | Rick Waits | | 203 | 152 | 51 |
| 1978-05-30 | @ CLE | 45 | L 1-5 | 29-16 | 2 | 6,069 | Dick Tidrow | Rick Wise | Rick Wise | Dick Tidrow | | 204 | 157 | 47 |
| 1978-05-31 | vs BAL | 46 | L 2-3 | 29-17 | 2 | 21,404 | Ed Figueroa | Mike Flanagan | Mike Flanagan | Ed Figueroa | | 206 | 160 | 46 |
| 1978-06-01 | vs BAL | 47 | L 0-1 | 29-18 | 2 | 19,943 | Jim Beattie | Jim Palmer | Jim Palmer | Jim Beattie | | 206 | 161 | 45 |
| 1978-06-02 | @ OAK | 48 | W 3-1 | 30-18 | 2 | 18,993 | Ron Guidry | John Henry Johnson | Ron Guidry | John Henry Johnson | Rich Gossage | 209 | 162 | 47 |
| 1978-06-03 | @ OAK | 49 | L 1-5 | 30-19 | 2 | 14,499 | Andy Messersmith | Matt Keough | Matt Keough | Andy Messersmith | | 210 | 167 | 43 |
| 1978-06-04 | @ OAK | 50 | L 4-6 | 30-20 | 2 | 19,289 | Don Gullett | John Henry Johnson | Bob Lacey | Rawly Eastwick | Elias Sosa | 214 | 173 | 41 |
| 1978-06-05 | @ SEA | 51 | L 3-7 | 30-21 | 2 | 15,189 | Ed Figueroa | Tom House | Tom House | Ed Figueroa | | 217 | 180 | 37 |
| 1978-06-06 | @ SEA | 52 | L 3-4 | 30-22 | 2 | 12,638 | Dick Tidrow | Byron McLaughlin | Shane Rawley | Rich Gossage | | 220 | 184 | 36 |
| 1978-06-07 | @ SEA | 53 | W 9-1 | 31-22 | 2 | 12,544 | Ron Guidry | Jim Colborn | Ron Guidry | Jim Colborn | | 229 | 185 | 44 |
| 1978-06-09 | @ CAL | 54 | W 3-1 | 32-22 | 2 | 29,415 | Ed Figueroa | Frank Tanana | Ed Figueroa | Frank Tanana | Rich Gossage | 232 | 186 | 46 |
| 1978-06-10 | @ CAL | 55 | L 3-4 | 32-23 | 2 | 37,848 | Don Gullett | Nolan Ryan | Dave LaRoche | Rich Gossage | | 235 | 190 | 45 |
| 1978-06-11 | @ CAL | 56 | L 6-9 | 32-24 | 2 | 31,646 | Dick Tidrow | Don Aase | Dyar Miller | Ken Clay | | 241 | 199 | 42 |
| 1978-06-12 | vs OAK | 57 | W 2-0 | 33-24 | 2 | 28,457 | Ron Guidry | Matt Keough | Ron Guidry | Dave Heaverlo | | 243 | 199 | 44 |
| 1978-06-13 | vs OAK | 58 | W 5-3 | 34-24 | 2 | 30,779 | Ed Figueroa | John Henry Johnson | Ed Figueroa | Rick Langford | Rich Gossage | 248 | 202 | 46 |
| 1978-06-14 | vs SEA | 59 | W 11-9 | 35-24 | 2 | 18,015 | Andy Messersmith | Tom House | Sparky Lyle | John Montague | | 259 | 211 | 48 |
| 1978-06-15 | vs SEA | 60 | W 5-2 | 36-24 | 2 | 18,643 | Don Gullett | Paul Mitchell | Don Gullett | Paul Mitchell | Sparky Lyle | 264 | 213 | 51 |
| 1978-06-16 | vs CAL | 61 | L 7-10 | 36-25 | 2 | 35,968 | Jim Beattie | Don Aase | Don Aase | Jim Beattie | | 271 | 223 | 48 |
| 1978-06-17 | vs CAL | 62 | W 4-0 | 37-25 | 2 | 33,162 | Ron Guidry | Paul Hartzell | Ron Guidry | Paul Hartzell | | 275 | 223 | 52 |
| 1978-06-18 | vs CAL | 63 | L 2-3 | 37-26 | 3 | 55,604 | Ed Figueroa | Chris Knapp | Chris Knapp | Ed Figueroa | | 277 | 226 | 51 |
| 1978-06-19 | @ BOS | 64 | L 4-10 | 37-27 | 4 | 33,163 | Ken Clay | Luis Tiant | Tom Burgmeier | Rich Gossage | | 281 | 236 | 45 |
| 1978-06-20 | @ BOS | 65 | W 10-4 | 38-27 | 3 | 32,643 | Don Gullett | Mike Torrez | Don Gullett | Mike Torrez | | 291 | 240 | 51 |
| 1978-06-21 | @ BOS | 66 | L 2-9 | 38-28 | 4 | 32,459 | Jim Beattie | Dennis Eckersley | Dennis Eckersley | Jim Beattie | | 293 | 249 | 44 |
| 1978-06-22 | @ DET | 67 | W 4-2 | 39-28 | 3 | 33,971 | Ron Guidry | Dave Rozema | Ron Guidry | Dave Rozema | Rich Gossage | 297 | 251 | 46 |
| 1978-06-23 | @ DET | 68 | W 12-3 | 40-28 | 3 | 39,022 | Ed Figueroa | Milt Wilcox | Sparky Lyle | Milt Wilcox | | 309 | 254 | 55 |
| 1978-06-24 | @ DET | 69 | L 3-4 | 40-29 | 3 | 37,681 | Ken Clay | Jim Slaton | Jim Slaton | Dick Tidrow | | 312 | 258 | 54 |
| 1978-06-25 | @ DET | 70 | W 4-2 | 41-29 | 2 | 34,014 | Don Gullett | Steve Baker | Don Gullett | Steve Baker | Rich Gossage | 316 | 260 | 56 |
| 1978-06-26 | vs BOS | 71 | L 1-4 | 41-30 | 2 | 52,124 | Andy Messersmith | Dennis Eckersley | Dennis Eckersley | Andy Messersmith | Bill Campbell | 317 | 264 | 53 |
| 1978-06-27 | vs BOS | 72 | W 6-4 | 42-30 | 2 | 55,132 | Ron Guidry | Jim Wright | Sparky Lyle | Dick Drago | | 323 | 268 | 55 |
| 1978-06-28 | @ MIL | 73 | L 0-5 | 42-32 | 3 | 0 | Dick Tidrow | Mike Caldwell | Mike Caldwell | Dick Tidrow | | 323 | 273 | 50 |
| 1978-06-28 | @ MIL | 74 | L 2-7 | 42-32 | 3 | 39,283 | Larry McCall | Jerry Augustine | Jerry Augustine | Larry McCall | | 325 | 280 | 45 |
| 1978-06-30 | vs DET | 75 | W 10-2 | 43-32 | 3 | 33,894 | Don Gullett | Steve Baker | Don Gullett | Steve Baker | | 335 | 282 | 53 |
| 1978-07-01 | vs DET | 76 | L 4-8 | 43-33 | 3 | 37,260 | Andy Messersmith | Jack Billingham | Jack Billingham | Andy Messersmith | | 339 | 290 | 49 |
| 1978-07-02 | vs DET | 77 | W 3-2 | 45-33 | 3 | 0 | Ron Guidry | Dave Rozema | Ron Guidry | John Hiller | Rich Gossage | 342 | 292 | 50 |
| 1978-07-02 | vs DET | 78 | W 5-3 | 45-33 | 3 | 51,327 | Dave Rajsich | Jim Slaton | Rich Gossage | Jim Slaton | | 347 | 295 | 52 |
| 1978-07-03 | @ BOS | 79 | L 5-9 | 45-34 | 3 | 34,722 | Ed Figueroa | Dennis Eckersley | Dennis Eckersley | Ed Figueroa | | 352 | 304 | 48 |
| 1978-07-05 | @ TEX | 80 | L 2-3 | 45-35 | 3 | 37,702 | Don Gullett | Jon Matlack | Jon Matlack | Don Gullett | | 354 | 307 | 47 |
| 1978-07-06 | @ TEX | 81 | W 7-2 | 46-35 | 2 | 37,930 | Dick Tidrow | Doc Medich | Dick Tidrow | Doc Medich | | 361 | 309 | 52 |
| 1978-07-07 | @ MIL | 82 | L 0-6 | 46-36 | 3 | 40,216 | Ron Guidry | Mike Caldwell | Mike Caldwell | Ron Guidry | | 361 | 315 | 46 |
| 1978-07-08 | @ MIL | 83 | L 5-6 | 46-37 | 3 | 46,518 | Dave Rajsich | Jerry Augustine | Eduardo Rodriguez | Rich Gossage | Bob McClure | 366 | 321 | 45 |
| 1978-07-09 | @ MIL | 84 | L 4-8 | 46-38 | 3 | 42,633 | Don Gullett | Bill Travers | Bill Travers | Don Gullett | Randy Stein | 370 | 329 | 41 |
| 1978-07-13 | vs CHA | 85 | L 1-6 | 46-39 | 3 | 28,532 | Dick Tidrow | Wilbur Wood | Wilbur Wood | Dick Tidrow | | 371 | 335 | 36 |
| 1978-07-14 | vs CHA | 86 | W 7-6 | 47-39 | 3 | 21,981 | Ron Guidry | Ken Kravec | Rich Gossage | Rich Hinton | | 378 | 341 | 37 |
| 1978-07-15 | vs KCA | 87 | L 2-8 | 47-40 | 3 | 34,979 | Ed Figueroa | Dennis Leonard | Dennis Leonard | Ed Figueroa | | 380 | 349 | 31 |
| 1978-07-16 | vs KCA | 88 | L 1-3 | 47-41 | 4 | 45,089 | Jim Beattie | Larry Gura | Larry Gura | Jim Beattie | Al Hrabosky | 381 | 352 | 29 |
| 1978-07-17 | vs KCA | 89 | L 7-9 | 47-42 | 4 | 27,020 | Catfish Hunter | Paul Splittorff | Al Hrabosky | Rich Gossage | | 388 | 361 | 27 |
| 1978-07-19 | @ MIN | 90 | W 2-0 | 48-42 | 4 | 29,591 | Ed Figueroa | Geoff Zahn | Ed Figueroa | Geoff Zahn | | 390 | 361 | 29 |
| 1978-07-20 | @ MIN | 91 | W 4-0 | 49-42 | 4 | 30,660 | Ron Guidry | Darrell Jackson | Ron Guidry | Darrell Jackson | | 394 | 361 | 33 |
| 1978-07-21 | @ CHA | 92 | W 7-4 | 50-42 | 4 | 30,348 | Jim Beattie | Francisco Barrios | Sparky Lyle | Rich Hinton | Rich Gossage | 401 | 365 | 36 |
| 1978-07-22 | @ CHA | 93 | W 7-2 | 51-42 | 3 | 32,163 | Catfish Hunter | Wilbur Wood | Catfish Hunter | Wilbur Wood | | 408 | 367 | 41 |
| 1978-07-23 | @ CHA | 94 | W 3-1 | 52-42 | 3 | 27,651 | Ed Figueroa | Ken Kravec | Ed Figueroa | Ken Kravec | Rich Gossage | 411 | 368 | 43 |
| 1978-07-24 | @ KCA | 95 | L 2-5 | 52-43 | 4 | 38,859 | Dick Tidrow | Dennis Leonard | Dennis Leonard | Dick Tidrow | | 413 | 373 | 40 |
| 1978-07-25 | @ KCA | 96 | W 4-0 | 53-43 | 4 | 40,183 | Ron Guidry | Paul Splittorff | Ron Guidry | Paul Splittorff | | 417 | 373 | 44 |
| 1978-07-26 | vs CLE | 97 | W 3-1 | 54-43 | 3 | 31,631 | Jim Beattie | Rick Waits | Rich Gossage | Rick Waits | | 420 | 374 | 46 |
| 1978-07-27 | vs CLE | 98 | W 11-0 | 55-44 | 4 | 0 | Ed Figueroa | David Clyde | Ed Figueroa | David Clyde | | 431 | 374 | 57 |
| 1978-07-27 | vs CLE | 99 | L 5-17 | 55-44 | 4 | 33,412 | Catfish Hunter | Don Hood | Don Hood | Catfish Hunter | | 436 | 391 | 45 |
| 1978-07-28 | vs MIN | 100 | L 5-7 | 55-45 | 4 | 25,037 | Dick Tidrow | Geoff Zahn | Mike Marshall | Sparky Lyle | | 441 | 398 | 43 |
| 1978-07-29 | vs MIN | 101 | W 7-3 | 56-45 | 4 | 46,711 | Ken Clay | Darrell Jackson | Ken Clay | Darrell Jackson | Rich Gossage | 448 | 401 | 47 |
| 1978-07-30 | vs MIN | 102 | W 4-3 | 57-46 | 4 | 0 | Ron Guidry | Roger Erickson | Rich Gossage | Mike Marshall | | 452 | 404 | 48 |
| 1978-07-30 | vs MIN | 103 | L 0-2 | 57-46 | 4 | 41,491 | Jim Beattie | Dave Goltz | Dave Goltz | Jim Beattie | Mike Marshall | 452 | 406 | 46 |
| 1978-07-31 | vs TEX | 104 | W 6-1 | 58-46 | 4 | 15,419 | Ed Figueroa | Doc Medich | Ed Figueroa | Doc Medich | | 458 | 407 | 51 |
| 1978-08-01 | vs TEX | 105 | W 8-1 | 59-46 | 3 | 18,485 | Catfish Hunter | Jon Matlack | Catfish Hunter | Jon Matlack | | 466 | 408 | 58 |
| 1978-08-02 | vs BOS | 106 | L 5-7 | 59-47 | 3 | 52,701 | Dick Tidrow | Andy Hassler | Bob Stanley | Ken Clay | | 471 | 415 | 56 |
| 1978-08-03 | vs BOS | 107 | L 1-8 | 59-48 | 4 | 53,379 | Jim Beattie | Mike Torrez | Mike Torrez | Jim Beattie | | 472 | 423 | 49 |
| 1978-08-04 | vs BAL | 108 | L 1-2 | 59-49 | 4 | 28,189 | Ron Guidry | Mike Flanagan | Mike Flanagan | Ron Guidry | Don Stanhouse | 473 | 425 | 48 |
| 1978-08-05 | vs BAL | 109 | W 3-2 | 60-49 | 4 | 26,727 | Ed Figueroa | Scott McGregor | Sparky Lyle | Tippy Martinez | | 476 | 427 | 49 |
| 1978-08-06 | vs BAL | 110 | W 3-0 | 61-49 | 3 | 40,765 | Catfish Hunter | Jim Palmer | Catfish Hunter | Jim Palmer | | 479 | 427 | 52 |
| 1978-08-08 | vs MIL | 111 | W 3-0 | 62-49 | 3 | 22,549 | Dick Tidrow | Mike Caldwell | Dick Tidrow | Mike Caldwell | Rich Gossage | 482 | 427 | 55 |
| 1978-08-09 | vs MIL | 112 | W 8-7 | 63-49 | 2 | 27,172 | Ed Figueroa | Lary Sorensen | Larry McCall | Bob McClure | | 490 | 434 | 56 |
| 1978-08-10 | vs MIL | 113 | W 9-0 | 64-49 | 2 | 35,127 | Ron Guidry | Jerry Augustine | Ron Guidry | Jerry Augustine | | 499 | 434 | 65 |
| 1978-08-11 | @ BAL | 114 | W 2-1 | 65-49 | 2 | 29,539 | Catfish Hunter | Dennis Martinez | Catfish Hunter | Dennis Martinez | | 501 | 435 | 66 |
| 1978-08-12 | @ BAL | 115 | L 4-6 | 65-50 | 2 | 32,153 | Jim Beattie | Mike Flanagan | Mike Flanagan | Jim Beattie | Don Stanhouse | 505 | 441 | 64 |
| 1978-08-13 | @ BAL | 116 | L 0-3 | 65-51 | 2 | 31,591 | Ed Figueroa | Scott McGregor | Scott McGregor | Ed Figueroa | | 505 | 444 | 61 |
| 1978-08-14 | @ BAL | 117 | W 4-1 | 66-51 | 2 | 30,397 | Dick Tidrow | Jim Palmer | Rich Gossage | Jim Palmer | | 509 | 445 | 64 |
| 1978-08-15 | @ OAK | 118 | W 6-0 | 67-51 | 2 | 13,862 | Ron Guidry | Rick Langford | Ron Guidry | Rick Langford | | 515 | 445 | 70 |
| 1978-08-16 | @ OAK | 119 | W 5-3 | 68-51 | 2 | 10,394 | Catfish Hunter | Pete Broberg | Catfish Hunter | Bob Lacey | Rich Gossage | 520 | 448 | 72 |
| 1978-08-18 | @ SEA | 120 | W 6-1 | 69-51 | 2 | 19,824 | Ed Figueroa | Paul Mitchell | Ed Figueroa | Paul Mitchell | | 526 | 449 | 77 |
| 1978-08-19 | @ SEA | 121 | L 1-4 | 69-52 | 2 | 29,915 | Dick Tidrow | Jim Colborn | Jim Colborn | Dick Tidrow | | 527 | 453 | 74 |
| 1978-08-20 | @ SEA | 122 | L 4-5 | 69-53 | 3 | 21,834 | Ron Guidry | Rick Honeycutt | Enrique Romo | Rich Gossage | | 531 | 458 | 73 |
| 1978-08-22 | @ CAL | 123 | W 6-2 | 70-53 | 3 | 35,644 | Catfish Hunter | Frank Tanana | Catfish Hunter | Frank Tanana | | 537 | 460 | 77 |
| 1978-08-23 | @ CAL | 124 | L 3-6 | 70-54 | 3 | 33,472 | Ed Figueroa | Chris Knapp | Chris Knapp | Ed Figueroa | Dave LaRoche | 540 | 466 | 74 |
| 1978-08-25 | vs OAK | 125 | W 7-1 | 71-54 | 2 | 29,010 | Ron Guidry | John Henry Johnson | Ron Guidry | John Henry Johnson | | 547 | 467 | 80 |
| 1978-08-26 | vs OAK | 126 | W 5-4 | 72-54 | 2 | 53,883 | Dick Tidrow | Matt Keough | Sparky Lyle | Bob Lacey | | 552 | 471 | 81 |
| 1978-08-27 | vs OAK | 127 | W 6-2 | 73-54 | 2 | 40,628 | Catfish Hunter | Rick Langford | Catfish Hunter | Rick Langford | Rich Gossage | 558 | 473 | 85 |
| 1978-08-28 | vs CAL | 128 | W 4-1 | 74-54 | 2 | 22,481 | Ed Figueroa | Frank Tanana | Ed Figueroa | Frank Tanana | Rich Gossage | 562 | 474 | 88 |
| 1978-08-29 | vs CAL | 129 | W 4-3 | 75-54 | 2 | 24,203 | Jim Beattie | Chris Knapp | Rich Gossage | Dave LaRoche | | 566 | 477 | 89 |
| 1978-08-30 | @ BAL | 130 | W 5-4 | 76-54 | 2 | 20,501 | Ron Guidry | Mike Flanagan | Ron Guidry | Tippy Martinez | Rich Gossage | 571 | 481 | 90 |
| 1978-08-31 | @ BAL | 131 | W 6-2 | 77-54 | 2 | 15,579 | Dick Tidrow | Scott McGregor | Dick Tidrow | Scott McGregor | Sparky Lyle | 577 | 483 | 94 |
| 1978-09-01 | vs SEA | 132 | L 0-3 | 77-55 | 2 | 20,167 | Catfish Hunter | Paul Mitchell | Paul Mitchell | Catfish Hunter | | 577 | 486 | 91 |
| 1978-09-02 | vs SEA | 133 | W 6-2 | 78-55 | 2 | 18,530 | Ed Figueroa | Jim Colborn | Ed Figueroa | Jim Colborn | | 583 | 488 | 95 |
| 1978-09-03 | vs SEA | 134 | W 4-3 | 79-55 | 2 | 22,386 | Jim Beattie | Rick Honeycutt | Jim Beattie | Rick Honeycutt | Rich Gossage | 587 | 491 | 96 |
| 1978-09-04 | vs DET | 135 | W 9-1 | 80-56 | 2 | 0 | Ron Guidry | Milt Wilcox | Ron Guidry | Milt Wilcox | | 596 | 492 | 104 |
| 1978-09-04 | vs DET | 136 | L 4-5 | 80-56 | 2 | 46,896 | Paul Lindblad | Jack Morris | John Hiller | Sparky Lyle | | 600 | 497 | 103 |
| 1978-09-05 | vs DET | 137 | W 4-2 | 81-56 | 2 | 16,891 | Dick Tidrow | Kip Young | Dick Tidrow | Kip Young | Rich Gossage | 604 | 499 | 105 |
| 1978-09-06 | vs DET | 138 | W 8-2 | 82-56 | 2 | 24,452 | Ed Figueroa | Jack Billingham | Ed Figueroa | Jack Billingham | | 612 | 501 | 111 |
| 1978-09-07 | @ BOS | 139 | W 15-3 | 83-56 | 2 | 34,119 | Catfish Hunter | Mike Torrez | Ken Clay | Mike Torrez | | 627 | 504 | 123 |
| 1978-09-08 | @ BOS | 140 | W 13-2 | 84-56 | 2 | 33,134 | Jim Beattie | Jim Wright | Jim Beattie | Jim Wright | | 640 | 506 | 134 |
| 1978-09-09 | @ BOS | 141 | W 7-0 | 85-56 | 2 | 33,611 | Ron Guidry | Dennis Eckersley | Ron Guidry | Dennis Eckersley | | 647 | 506 | 141 |
| 1978-09-10 | @ BOS | 142 | W 7-4 | 86-56 | 2 | 32,786 | Ed Figueroa | Bobby Sprowl | Ed Figueroa | Bobby Sprowl | Rich Gossage | 654 | 510 | 144 |
| 1978-09-12 | @ DET | 143 | L 4-7 | 86-57 | 2 | 14,162 | Dick Tidrow | Kip Young | Kip Young | Dick Tidrow | John Hiller | 658 | 517 | 141 |
| 1978-09-13 | @ DET | 144 | W 7-3 | 87-57 | 1 | 16,841 | Jim Beattie | Jack Billingham | Jim Beattie | Jack Billingham | | 665 | 520 | 145 |
| 1978-09-14 | @ DET | 145 | W 4-2 | 88-57 | 1 | 17,118 | Ed Figueroa | Jim Slaton | Ed Figueroa | Jim Slaton | Sparky Lyle | 669 | 522 | 147 |
| 1978-09-15 | vs BOS | 146 | W 4-0 | 89-57 | 1 | 54,901 | Ron Guidry | Luis Tiant | Ron Guidry | Luis Tiant | | 673 | 522 | 151 |
| 1978-09-16 | vs BOS | 147 | W 3-2 | 90-57 | 1 | 55,091 | Catfish Hunter | Mike Torrez | Catfish Hunter | Mike Torrez | | 676 | 524 | 152 |
| 1978-09-17 | vs BOS | 148 | L 3-7 | 90-58 | 1 | 55,088 | Jim Beattie | Dennis Eckersley | Dennis Eckersley | Jim Beattie | Bob Stanley | 679 | 531 | 148 |
| 1978-09-18 | vs MIL | 149 | W 4-3 | 91-58 | 1 | 20,557 | Ed Figueroa | Bill Travers | Ed Figueroa | Bill Travers | | 683 | 534 | 149 |
| 1978-09-19 | vs MIL | 150 | L 0-2 | 91-59 | 1 | 26,682 | Dick Tidrow | Mike Caldwell | Mike Caldwell | Dick Tidrow | | 683 | 536 | 147 |
| 1978-09-20 | @ TOR | 151 | L 1-8 | 92-60 | 1 | 0 | Ron Guidry | Mike Willis | Mike Willis | Ron Guidry | | 684 | 544 | 140 |
| 1978-09-20 | @ TOR | 152 | W 3-2 | 92-60 | 1 | 38,080 | Ken Clay | Tom Underwood | Rich Gossage | Victor Cruz | | 687 | 546 | 141 |
| 1978-09-21 | @ TOR | 153 | W 7-1 | 93-60 | 1 | 28,653 | Catfish Hunter | Balor Moore | Catfish Hunter | Balor Moore | Rich Gossage | 694 | 547 | 147 |
| 1978-09-22 | @ CLE | 154 | L 7-8 | 93-61 | 1 | 10,035 | Ed Figueroa | Rick Waits | Sid Monge | Rich Gossage | | 701 | 555 | 146 |
| 1978-09-23 | @ CLE | 155 | L 1-10 | 93-62 | 1 | 17,452 | Jim Beattie | David Clyde | David Clyde | Jim Beattie | | 702 | 565 | 137 |
| 1978-09-24 | @ CLE | 156 | W 4-0 | 94-62 | 1 | 15,855 | Ron Guidry | Mike Paxton | Ron Guidry | Mike Paxton | | 706 | 565 | 141 |
| 1978-09-26 | vs TOR | 157 | W 4-1 | 95-62 | 1 | 20,535 | Ed Figueroa | Tom Underwood | Ed Figueroa | Tom Underwood | Rich Gossage | 710 | 566 | 144 |
| 1978-09-27 | vs TOR | 158 | W 5-1 | 96-62 | 1 | 20,052 | Catfish Hunter | Mike Willis | Catfish Hunter | Mike Willis | | 715 | 567 | 148 |
| 1978-09-28 | vs TOR | 159 | W 3-1 | 97-62 | 1 | 30,480 | Ron Guidry | Balor Moore | Ron Guidry | Balor Moore | | 718 | 568 | 150 |
| 1978-09-29 | vs CLE | 160 | W 3-1 | 98-62 | 1 | 30,253 | Jim Beattie | David Clyde | Jim Beattie | Jim Kern | Rich Gossage | 721 | 569 | 152 |
| 1978-09-30 | vs CLE | 161 | W 7-0 | 99-62 | 1 | 55,219 | Ed Figueroa | Mike Paxton | Ed Figueroa | Mike Paxton | | 728 | 569 | 159 |
| 1978-10-01 | vs CLE | 162 | L 2-9 | 99-63 | 2 | 39,189 | Catfish Hunter | Rick Waits | Rick Waits | Catfish Hunter | | 730 | 578 | 152 |
| 1978-10-02 | @ BOS | 163 | W 5-4 | 100-63 | 1 | 32,925 | Ron Guidry | Mike Torrez | Ron Guidry | Mike Torrez | Rich Gossage | 735 | 582 | 153 |