| 1978-04-07 | @ NYN | 1 | L 1-3 | 0-1 | 5 | 11,736 | Steve Rogers | Jerry Koosman | Jerry Koosman | Steve Rogers | | 1 | 3 | -2 |
| 1978-04-08 | @ NYN | 2 | L 5-6 | 0-2 | 6 | 7,259 | Rudy May | Nino Espinosa | Mardie Cornejo | Stan Bahnsen | | 6 | 9 | -3 |
| 1978-04-09 | @ NYN | 3 | L 5-6 | 1-3 | 6 | 0 | Wayne Twitchell | Pat Zachry | Pat Zachry | Wayne Twitchell | Mardie Cornejo | 11 | 15 | -4 |
| 1978-04-09 | @ NYN | 4 | W 5-0 | 1-3 | 6 | 30,448 | Ross Grimsley | Mike Bruhert | Ross Grimsley | Mike Bruhert | | 16 | 15 | 1 |
| 1978-04-12 | @ PHI | 5 | W 8-7 | 2-3 | 5 | 19,110 | Steve Rogers | Jim Lonborg | Steve Rogers | Jim Lonborg | Bill Atkinson | 24 | 22 | 2 |
| 1978-04-14 | vs NYN | 6 | L 2-3 | 2-4 | 5 | 37,172 | Rudy May | Pat Zachry | Mardie Cornejo | Rudy May | Skip Lockwood | 26 | 25 | 1 |
| 1978-04-15 | vs NYN | 7 | W 4-3 | 3-4 | 5 | 12,617 | Wayne Twitchell | Craig Swan | Bill Atkinson | Bob Myrick | | 30 | 28 | 2 |
| 1978-04-16 | vs NYN | 8 | W 4-1 | 4-4 | 4 | 18,790 | Ross Grimsley | Jerry Koosman | Ross Grimsley | Jerry Koosman | | 34 | 29 | 5 |
| 1978-04-18 | @ CHN | 9 | L 1-2 | 4-5 | 5 | 2,010 | Steve Rogers | Ray Burris | Ray Burris | Steve Rogers | Bruce Sutter | 35 | 31 | 4 |
| 1978-04-19 | @ CHN | 10 | W 8-6 | 5-5 | 4 | 2,227 | Rudy May | Woodie Fryman | Darold Knowles | Bruce Sutter | | 43 | 37 | 6 |
| 1978-04-22 | vs PHI | 11 | W 7-3 | 7-5 | 2 | 0 | Wayne Twitchell | Steve Carlton | Wayne Twitchell | Steve Carlton | Stan Bahnsen | 50 | 40 | 10 |
| 1978-04-22 | vs PHI | 12 | W 5-3 | 7-5 | 2 | 19,237 | Ross Grimsley | Larry Christenson | Ross Grimsley | Larry Christenson | Stan Bahnsen | 55 | 43 | 12 |
| 1978-04-23 | vs PHI | 13 | W 5-2 | 8-5 | 1 | 17,922 | Steve Rogers | Jim Lonborg | Steve Rogers | Jim Lonborg | Darold Knowles | 60 | 45 | 15 |
| 1978-04-24 | vs SLN | 14 | W 5-3 | 9-5 | 1 | 11,448 | Rudy May | Eric Rasmussen | Rudy May | Mark Littell | Stan Bahnsen | 65 | 48 | 17 |
| 1978-04-25 | vs SLN | 15 | L 2-7 | 9-6 | 1 | 12,444 | Hal Dues | John Urrea | John Urrea | Hal Dues | | 67 | 55 | 12 |
| 1978-04-26 | vs SLN | 16 | L 2-12 | 9-7 | 1 | 10,999 | Wayne Twitchell | John Denny | John Denny | Wayne Twitchell | | 69 | 67 | 2 |
| 1978-04-28 | @ HOU | 17 | W 6-3 | 10-7 | 1 | 11,474 | Ross Grimsley | Joe Niekro | Ross Grimsley | Joe Niekro | | 75 | 70 | 5 |
| 1978-04-29 | @ HOU | 18 | L 1-3 | 10-8 | 2 | 46,215 | Steve Rogers | Joaquin Andujar | Joaquin Andujar | Steve Rogers | | 76 | 73 | 3 |
| 1978-04-30 | @ HOU | 19 | W 2-1 | 11-8 | 2 | 11,515 | Rudy May | Mark Lemongello | Rudy May | Mark Lemongello | Stan Bahnsen | 78 | 74 | 4 |
| 1978-05-03 | vs HOU | 20 | W 10-3 | 12-8 | 1 | 5,229 | Ross Grimsley | J.R. Richard | Ross Grimsley | J.R. Richard | | 88 | 77 | 11 |
| 1978-05-05 | @ CIN | 21 | W 4-3 | 13-8 | 1 | 37,823 | Steve Rogers | Tom Hume | Steve Rogers | Tom Hume | | 92 | 80 | 12 |
| 1978-05-06 | @ CIN | 22 | L 2-6 | 13-9 | 2 | 50,142 | Rudy May | Tom Seaver | Tom Seaver | Rudy May | Pedro Borbon | 94 | 86 | 8 |
| 1978-05-07 | @ CIN | 23 | W 19-5 | 14-10 | 2 | 0 | Wayne Twitchell | Paul Moskau | Wayne Twitchell | Paul Moskau | | 113 | 91 | 22 |
| 1978-05-07 | @ CIN | 24 | L 2-4 | 14-10 | 2 | 35,037 | Ross Grimsley | Manny Sarmiento | Manny Sarmiento | Ross Grimsley | Doug Bair | 115 | 95 | 20 |
| 1978-05-09 | @ ATL | 25 | L 2-3 | 15-11 | 2 | 0 | Steve Rogers | Dick Ruthven | Dave Campbell | Bill Atkinson | | 117 | 98 | 19 |
| 1978-05-09 | @ ATL | 26 | W 7-6 | 15-11 | 2 | 8,636 | Hal Dues | Phil Niekro | Bill Atkinson | Eddie Solomon | | 124 | 104 | 20 |
| 1978-05-10 | vs NYN | 27 | L 2-7 | 15-12 | 2 | 7,279 | Rudy May | Nino Espinosa | Nino Espinosa | Rudy May | | 126 | 111 | 15 |
| 1978-05-11 | vs NYN | 28 | L 2-3 | 15-13 | 2 | 6,930 | Wayne Twitchell | Pat Zachry | Pat Zachry | Stan Bahnsen | Skip Lockwood | 128 | 114 | 14 |
| 1978-05-12 | vs ATL | 29 | W 5-3 | 16-13 | 2 | 8,522 | Ross Grimsley | Preston Hanna | Ross Grimsley | Rick Camp | Stan Bahnsen | 133 | 117 | 16 |
| 1978-05-13 | vs ATL | 30 | W 3-0 | 17-13 | 2 | 10,147 | Steve Rogers | Phil Niekro | Steve Rogers | Phil Niekro | | 136 | 117 | 19 |
| 1978-05-14 | vs ATL | 31 | L 1-2 | 17-14 | 2 | 13,925 | Rudy May | Dick Ruthven | Dick Ruthven | Rudy May | | 137 | 119 | 18 |
| 1978-05-16 | vs CIN | 32 | L 1-5 | 17-15 | 2 | 10,725 | Wayne Twitchell | Tom Seaver | Tom Seaver | Wayne Twitchell | | 138 | 124 | 14 |
| 1978-05-17 | vs CIN | 33 | W 5-4 | 18-15 | 2 | 11,826 | Ross Grimsley | Bill Bonham | Darold Knowles | Dale Murray | | 143 | 128 | 15 |
| 1978-05-18 | vs CIN | 34 | L 2-3 | 18-16 | 2 | 9,435 | Steve Rogers | Fred Norman | Fred Norman | Steve Rogers | Pedro Borbon | 145 | 131 | 14 |
| 1978-05-19 | vs PIT | 35 | L 3-5 | 18-17 | 2 | 13,088 | Rudy May | Don Robinson | Don Robinson | Rudy May | Kent Tekulve | 148 | 136 | 12 |
| 1978-05-20 | vs PIT | 36 | L 0-6 | 18-18 | 3 | 13,834 | Wayne Twitchell | Bert Blyleven | Bert Blyleven | Wayne Twitchell | | 148 | 142 | 6 |
| 1978-05-21 | vs PIT | 37 | L 0-7 | 18-19 | 3 | 20,016 | Ross Grimsley | John Candelaria | John Candelaria | Ross Grimsley | Kent Tekulve | 148 | 149 | -1 |
| 1978-05-22 | vs PIT | 38 | W 5-2 | 19-19 | 3 | 12,300 | Steve Rogers | Jim Rooker | Steve Rogers | Jim Rooker | Darold Knowles | 153 | 151 | 2 |
| 1978-05-23 | @ SLN | 39 | W 4-1 | 20-19 | 3 | 11,128 | Rudy May | Bob Forsch | Rudy May | Bob Forsch | Mike Garman | 157 | 152 | 5 |
| 1978-05-24 | @ SLN | 40 | L 0-2 | 20-20 | 3 | 12,135 | Hal Dues | John Denny | John Denny | Hal Dues | | 157 | 154 | 3 |
| 1978-05-25 | @ SLN | 41 | W 11-2 | 21-20 | 3 | 8,948 | Ross Grimsley | John Urrea | Ross Grimsley | John Urrea | | 168 | 156 | 12 |
| 1978-05-26 | @ PIT | 42 | L 1-2 | 21-21 | 2 | 8,816 | Steve Rogers | John Candelaria | John Candelaria | Steve Rogers | Kent Tekulve | 169 | 158 | 11 |
| 1978-05-27 | @ PIT | 43 | W 15-1 | 22-21 | 3 | 10,773 | Rudy May | Jim Rooker | Rudy May | Jim Rooker | | 184 | 159 | 25 |
| 1978-05-28 | @ PIT | 44 | L 2-5 | 22-22 | 2 | 26,564 | Hal Dues | Jim Bibby | Jim Bibby | Hal Dues | | 186 | 164 | 22 |
| 1978-05-29 | vs CHN | 45 | W 4-2 | 23-22 | 3 | 22,934 | Ross Grimsley | Woodie Fryman | Ross Grimsley | Donnie Moore | | 190 | 166 | 24 |
| 1978-05-30 | vs CHN | 46 | W 7-4 | 24-22 | 3 | 16,106 | Steve Rogers | Rick Reuschel | Steve Rogers | Rick Reuschel | Mike Garman | 197 | 170 | 27 |
| 1978-05-31 | vs CHN | 47 | W 9-1 | 25-22 | 2 | 18,647 | Rudy May | Dennis Lamp | Rudy May | Dennis Lamp | | 206 | 171 | 35 |
| 1978-06-02 | vs SFN | 48 | L 5-6 | 25-23 | 3 | 18,410 | Wayne Twitchell | John Montefusco | Gary Lavelle | Darold Knowles | Randy Moffitt | 211 | 177 | 34 |
| 1978-06-03 | vs SFN | 49 | W 5-3 | 26-23 | 3 | 30,120 | Ross Grimsley | Ed Halicki | Ross Grimsley | Ed Halicki | | 216 | 180 | 36 |
| 1978-06-04 | vs SFN | 50 | L 2-3 | 26-24 | 3 | 31,273 | Steve Rogers | Bob Knepper | Randy Moffitt | Mike Garman | | 218 | 183 | 35 |
| 1978-06-05 | vs SDN | 51 | W 4-3 | 27-24 | 3 | 12,909 | Rudy May | Eric Rasmussen | Rudy May | Eric Rasmussen | Mike Garman | 222 | 186 | 36 |
| 1978-06-06 | vs SDN | 52 | W 4-0 | 28-24 | 3 | 13,702 | Wayne Twitchell | Bob Shirley | Wayne Twitchell | Bob Shirley | Bill Atkinson | 226 | 186 | 40 |
| 1978-06-07 | vs SDN | 53 | W 8-3 | 29-24 | 3 | 11,786 | Ross Grimsley | Randy Jones | Ross Grimsley | Randy Jones | | 234 | 189 | 45 |
| 1978-06-08 | vs LAN | 54 | W 4-1 | 30-24 | 3 | 20,004 | Steve Rogers | Don Sutton | Steve Rogers | Don Sutton | | 238 | 190 | 48 |
| 1978-06-09 | vs LAN | 55 | W 10-9 | 31-24 | 3 | 21,719 | Rudy May | Tommy John | Dan Schatzeder | Tommy John | Darold Knowles | 248 | 199 | 49 |
| 1978-06-10 | vs LAN | 56 | L 4-5 | 31-25 | 3 | 39,104 | Wayne Twitchell | Rick Rhoden | Lance Rautzhan | Bill Atkinson | Terry Forster | 252 | 204 | 48 |
| 1978-06-11 | vs LAN | 57 | L 4-11 | 31-26 | 3 | 48,389 | Ross Grimsley | Doug Rau | Charlie Hough | Ross Grimsley | | 256 | 215 | 41 |
| 1978-06-12 | @ SFN | 58 | L 0-1 | 31-27 | 3 | 7,231 | Steve Rogers | Ed Halicki | Ed Halicki | Steve Rogers | | 256 | 216 | 40 |
| 1978-06-13 | @ SFN | 59 | L 5-9 | 31-28 | 3 | 26,277 | Rudy May | Bob Knepper | Bob Knepper | Rudy May | | 261 | 225 | 36 |
| 1978-06-14 | @ SDN | 60 | L 2-6 | 31-30 | 3 | 0 | Wayne Twitchell | Eric Rasmussen | Eric Rasmussen | Wayne Twitchell | John D'Acquisto | 263 | 231 | 32 |
| 1978-06-14 | @ SDN | 61 | L 0-1 | 31-30 | 3 | 18,765 | Woodie Fryman | Gaylord Perry | Gaylord Perry | Woodie Fryman | | 263 | 232 | 31 |
| 1978-06-15 | @ SDN | 62 | W 3-1 | 32-30 | 3 | 9,253 | Ross Grimsley | Bob Shirley | Ross Grimsley | Bob Shirley | | 266 | 233 | 33 |
| 1978-06-16 | @ LAN | 63 | L 1-2 | 32-31 | 3 | 45,538 | Steve Rogers | Doug Rau | Doug Rau | Steve Rogers | | 267 | 235 | 32 |
| 1978-06-17 | @ LAN | 64 | W 6-3 | 33-31 | 3 | 51,247 | Rudy May | Burt Hooton | Dan Schatzeder | Burt Hooton | Hal Dues | 273 | 238 | 35 |
| 1978-06-18 | @ LAN | 65 | L 0-5 | 33-32 | 3 | 41,769 | Wayne Twitchell | Don Sutton | Don Sutton | Wayne Twitchell | | 273 | 243 | 30 |
| 1978-06-20 | @ NYN | 66 | L 0-3 | 33-33 | 3 | 11,950 | Ross Grimsley | Nino Espinosa | Nino Espinosa | Ross Grimsley | | 273 | 246 | 27 |
| 1978-06-21 | @ NYN | 67 | W 2-1 | 34-33 | 3 | 6,691 | Steve Rogers | Mike Bruhert | Steve Rogers | Mike Bruhert | | 275 | 247 | 28 |
| 1978-06-22 | @ NYN | 68 | W 2-0 | 35-33 | 3 | 7,800 | Hal Dues | Pat Zachry | Hal Dues | Pat Zachry | Mike Garman | 277 | 247 | 30 |
| 1978-06-23 | @ SLN | 69 | L 4-8 | 35-34 | 3 | 13,732 | Rudy May | Pete Vuckovich | Pete Vuckovich | Rudy May | Mark Littell | 281 | 255 | 26 |
| 1978-06-24 | @ SLN | 70 | W 2-0 | 36-34 | 3 | 19,122 | Woodie Fryman | Silvio Martinez | Woodie Fryman | Silvio Martinez | Mike Garman | 283 | 255 | 28 |
| 1978-06-25 | @ SLN | 71 | L 5-7 | 36-35 | 3 | 22,671 | Ross Grimsley | Bob Forsch | Buddy Schultz | Rudy May | | 288 | 262 | 26 |
| 1978-06-26 | vs PHI | 72 | W 5-1 | 37-35 | 3 | 19,487 | Steve Rogers | Steve Carlton | Steve Rogers | Steve Carlton | | 293 | 263 | 30 |
| 1978-06-27 | vs PHI | 73 | L 0-1 | 37-36 | 3 | 36,885 | Hal Dues | Dick Ruthven | Dick Ruthven | Hal Dues | | 293 | 264 | 29 |
| 1978-06-28 | vs PHI | 74 | L 5-7 | 37-37 | 3 | 35,182 | Dan Schatzeder | Jim Lonborg | Jim Lonborg | Mike Garman | Tug McGraw | 298 | 271 | 27 |
| 1978-06-30 | vs SLN | 75 | L 1-2 | 37-38 | 3 | 22,829 | Ross Grimsley | Bob Forsch | Bob Forsch | Ross Grimsley | Roy Thomas | 299 | 273 | 26 |
| 1978-07-01 | vs SLN | 76 | W 3-2 | 38-38 | 3 | 17,906 | Steve Rogers | John Denny | Steve Rogers | Mark Littell | | 302 | 275 | 27 |
| 1978-07-02 | vs SLN | 77 | L 4-5 | 38-40 | 3 | 0 | Woodie Fryman | Pete Vuckovich | Pete Vuckovich | Woodie Fryman | Buddy Schultz | 306 | 280 | 26 |
| 1978-07-02 | vs SLN | 78 | L 2-4 | 38-40 | 3 | 37,685 | Rudy May | John Urrea | John Urrea | Rudy May | Roy Thomas | 308 | 284 | 24 |
| 1978-07-03 | @ PIT | 79 | W 2-0 | 39-40 | 3 | 7,480 | Hal Dues | John Candelaria | Hal Dues | John Candelaria | Steve Rogers | 310 | 284 | 26 |
| 1978-07-04 | @ PIT | 80 | L 1-3 | 39-42 | 4 | 0 | Dan Schatzeder | Bert Blyleven | Bert Blyleven | Dan Schatzeder | Kent Tekulve | 311 | 287 | 24 |
| 1978-07-04 | @ PIT | 81 | L 3-4 | 39-42 | 4 | 15,001 | Wayne Twitchell | Don Robinson | Don Robinson | Wayne Twitchell | Kent Tekulve | 314 | 291 | 23 |
| 1978-07-06 | @ PHI | 82 | L 6-7 | 39-43 | 4 | 50,149 | Ross Grimsley | Jim Kaat | Rawly Eastwick | Ross Grimsley | | 320 | 298 | 22 |
| 1978-07-07 | @ PHI | 83 | W 7-4 | 40-43 | 4 | 45,193 | Steve Rogers | Dick Ruthven | Steve Rogers | Dick Ruthven | Mike Garman | 327 | 302 | 25 |
| 1978-07-08 | @ PHI | 84 | L 3-6 | 41-44 | 4 | 0 | Woodie Fryman | Larry Christenson | Larry Christenson | Woodie Fryman | Ron Reed | 330 | 308 | 22 |
| 1978-07-08 | @ PHI | 85 | W 8-1 | 41-44 | 4 | 50,098 | Hal Dues | Jim Lonborg | Hal Dues | Jim Lonborg | | 338 | 309 | 29 |
| 1978-07-09 | @ PHI | 86 | L 7-8 | 41-45 | 4 | 40,949 | Dan Schatzeder | Steve Carlton | Tug McGraw | Darold Knowles | | 345 | 317 | 28 |
| 1978-07-13 | vs HOU | 87 | W 6-0 | 42-45 | 4 | 15,337 | Ross Grimsley | Joe Niekro | Ross Grimsley | Joe Niekro | | 351 | 317 | 34 |
| 1978-07-14 | vs HOU | 88 | L 3-4 | 42-47 | 4 | 0 | Steve Rogers | J.R. Richard | Ken Forsch | Stan Bahnsen | | 354 | 321 | 33 |
| 1978-07-14 | vs HOU | 89 | L 4-5 | 42-47 | 4 | 21,696 | Hal Dues | Mark Lemongello | Ken Forsch | Gerry Pirtle | Bo McLaughlin | 358 | 326 | 32 |
| 1978-07-15 | vs HOU | 90 | W 8-0 | 43-47 | 4 | 15,360 | Woodie Fryman | Tom Dixon | Woodie Fryman | Tom Dixon | | 366 | 326 | 40 |
| 1978-07-16 | vs HOU | 91 | W 6-1 | 44-47 | 4 | 21,440 | Dan Schatzeder | Floyd Bannister | Dan Schatzeder | Floyd Bannister | | 372 | 327 | 45 |
| 1978-07-17 | @ CIN | 92 | L 6-8 | 44-48 | 4 | 32,113 | Ross Grimsley | Fred Norman | Manny Sarmiento | Stan Bahnsen | Doug Bair | 378 | 335 | 43 |
| 1978-07-18 | @ CIN | 93 | W 3-1 | 45-48 | 4 | 36,739 | Hal Dues | Tom Seaver | Hal Dues | Tom Seaver | Mike Garman | 381 | 336 | 45 |
| 1978-07-19 | vs ATL | 94 | W 8-6 | 46-49 | 4 | 0 | Rudy May | Tommy Boggs | Mike Garman | Gene Garber | | 389 | 342 | 47 |
| 1978-07-19 | vs ATL | 95 | L 1-3 | 46-49 | 4 | 20,282 | Wayne Twitchell | Eddie Solomon | Eddie Solomon | Wayne Twitchell | Dave Campbell | 390 | 345 | 45 |
| 1978-07-20 | vs ATL | 96 | W 7-3 | 47-49 | 4 | 14,108 | Woodie Fryman | Jamie Easterly | Woodie Fryman | Jamie Easterly | Mike Garman | 397 | 348 | 49 |
| 1978-07-21 | vs CIN | 97 | L 3-10 | 47-50 | 4 | 25,825 | Ross Grimsley | Mike LaCoss | Mike LaCoss | Ross Grimsley | | 400 | 358 | 42 |
| 1978-07-22 | vs CIN | 98 | L 1-2 | 47-51 | 4 | 28,920 | Dan Schatzeder | Fred Norman | Fred Norman | Dan Schatzeder | Doug Bair | 401 | 360 | 41 |
| 1978-07-23 | vs CIN | 99 | L 4-5 | 47-52 | 4 | 28,391 | Steve Rogers | Tom Seaver | Manny Sarmiento | Wayne Twitchell | Pedro Borbon | 405 | 365 | 40 |
| 1978-07-24 | @ HOU | 100 | L 5-6 | 47-53 | 4 | 7,843 | Hal Dues | Mark Lemongello | Ken Forsch | Darold Knowles | | 410 | 371 | 39 |
| 1978-07-25 | @ HOU | 101 | L 2-3 | 47-54 | 4 | 8,383 | Woodie Fryman | Vern Ruhle | Ken Forsch | Wayne Twitchell | | 412 | 374 | 38 |
| 1978-07-26 | @ HOU | 102 | L 0-5 | 47-55 | 4 | 8,465 | Ross Grimsley | Joe Niekro | Joe Niekro | Ross Grimsley | | 412 | 379 | 33 |
| 1978-07-28 | @ ATL | 103 | L 4-6 | 48-56 | 4 | 0 | Steve Rogers | Larry McWilliams | Dave Campbell | Gerry Pirtle | Gene Garber | 416 | 385 | 31 |
| 1978-07-28 | @ ATL | 104 | W 4-1 | 48-56 | 4 | 23,297 | Dan Schatzeder | Preston Hanna | Dan Schatzeder | Preston Hanna | Mike Garman | 420 | 386 | 34 |
| 1978-07-29 | @ ATL | 105 | L 6-9 | 48-57 | 4 | 16,734 | Stan Bahnsen | Mickey Mahler | Jamie Easterly | Mike Garman | Phil Niekro | 426 | 395 | 31 |
| 1978-07-30 | @ ATL | 106 | W 19-0 | 49-57 | 4 | 10,834 | Woodie Fryman | Tommy Boggs | Woodie Fryman | Tommy Boggs | | 445 | 395 | 50 |
| 1978-07-31 | vs PIT | 107 | W 3-2 | 50-57 | 4 | 22,152 | Ross Grimsley | Bert Blyleven | Mike Garman | Bert Blyleven | | 448 | 397 | 51 |
| 1978-08-01 | vs PIT | 108 | W 4-3 | 51-57 | 4 | 21,287 | Steve Rogers | Jim Bibby | Steve Rogers | Jim Bibby | Darold Knowles | 452 | 400 | 52 |
| 1978-08-02 | vs PIT | 109 | L 0-3 | 51-58 | 4 | 15,378 | Dan Schatzeder | Bruce Kison | Bruce Kison | Dan Schatzeder | Kent Tekulve | 452 | 403 | 49 |
| 1978-08-04 | @ CHN | 110 | L 4-6 | 51-59 | 4 | 20,621 | Woodie Fryman | Rick Reuschel | Rick Reuschel | Mike Garman | Bruce Sutter | 456 | 409 | 47 |
| 1978-08-05 | @ CHN | 111 | W 7-4 | 52-59 | 4 | 31,219 | Ross Grimsley | Dave Roberts | Ross Grimsley | Dave Roberts | Stan Bahnsen | 463 | 413 | 50 |
| 1978-08-06 | @ CHN | 112 | W 2-1 | 53-60 | 4 | 0 | Steve Rogers | Dennis Lamp | Steve Rogers | Dennis Lamp | Darold Knowles | 465 | 414 | 51 |
| 1978-08-06 | @ CHN | 113 | L 3-4 | 53-60 | 4 | 39,234 | Scott Sanderson | Ray Burris | Lynn McGlothen | Mike Garman | Bruce Sutter | 468 | 418 | 50 |
| 1978-08-08 | vs NYN | 114 | W 6-1 | 54-60 | 3 | 17,124 | Dan Schatzeder | Tom Hausman | Dan Schatzeder | Tom Hausman | | 474 | 419 | 55 |
| 1978-08-09 | vs NYN | 115 | L 3-10 | 54-61 | 3 | 16,910 | Woodie Fryman | Craig Swan | Craig Swan | Wayne Twitchell | | 477 | 429 | 48 |
| 1978-08-11 | vs CHN | 116 | W 1-0 | 55-61 | 3 | 17,956 | Ross Grimsley | Dennis Lamp | Ross Grimsley | Dennis Lamp | | 478 | 429 | 49 |
| 1978-08-12 | vs CHN | 117 | W 4-3 | 56-61 | 3 | 26,767 | Steve Rogers | Mike Krukow | Stan Bahnsen | Donnie Moore | | 482 | 432 | 50 |
| 1978-08-13 | vs CHN | 118 | L 1-2 | 56-62 | 3 | 24,394 | Scott Sanderson | Rick Reuschel | Rick Reuschel | Scott Sanderson | | 483 | 434 | 49 |
| 1978-08-15 | vs SFN | 119 | W 4-3 | 57-62 | 3 | 21,414 | Dan Schatzeder | Jim Barr | Hal Dues | Charlie Williams | | 487 | 437 | 50 |
| 1978-08-16 | vs SFN | 120 | W 1-0 | 58-62 | 3 | 21,893 | Woodie Fryman | Vida Blue | Woodie Fryman | Vida Blue | | 488 | 437 | 51 |
| 1978-08-17 | vs SFN | 121 | L 0-3 | 58-63 | 3 | 20,019 | Ross Grimsley | Ed Halicki | Ed Halicki | Ross Grimsley | | 488 | 440 | 48 |
| 1978-08-18 | vs SDN | 122 | L 2-3 | 58-64 | 4 | 17,042 | Steve Rogers | Eric Rasmussen | Eric Rasmussen | Steve Rogers | Mark Lee | 490 | 443 | 47 |
| 1978-08-19 | vs SDN | 123 | L 2-3 | 58-65 | 4 | 21,676 | Dan Schatzeder | Randy Jones | Randy Jones | Dan Schatzeder | Rollie Fingers | 492 | 446 | 46 |
| 1978-08-20 | vs SDN | 124 | L 4-5 | 58-66 | 4 | 20,094 | Woodie Fryman | Bob Owchinko | Mark Lee | Hal Dues | Rollie Fingers | 496 | 451 | 45 |
| 1978-08-21 | vs LAN | 125 | W 4-2 | 59-66 | 4 | 25,461 | Ross Grimsley | Bob Welch | Ross Grimsley | Bob Welch | | 500 | 453 | 47 |
| 1978-08-23 | vs LAN | 126 | L 2-4 | 59-67 | 4 | 31,696 | Steve Rogers | Burt Hooton | Burt Hooton | Steve Rogers | Charlie Hough | 502 | 457 | 45 |
| 1978-08-25 | @ SFN | 127 | W 8-5 | 60-67 | 4 | 15,368 | Dan Schatzeder | John Montefusco | Dan Schatzeder | Greg Minton | Stan Bahnsen | 510 | 462 | 48 |
| 1978-08-26 | @ SFN | 128 | L 1-4 | 60-68 | 4 | 16,235 | Woodie Fryman | Jim Barr | Jim Barr | Woodie Fryman | | 511 | 466 | 45 |
| 1978-08-27 | @ SFN | 129 | W 2-1 | 61-69 | 4 | 0 | Ross Grimsley | Vida Blue | Ross Grimsley | Vida Blue | | 513 | 467 | 46 |
| 1978-08-27 | @ SFN | 130 | L 2-11 | 61-69 | 4 | 28,633 | Scott Sanderson | Ed Halicki | Ed Halicki | Scott Sanderson | | 515 | 478 | 37 |
| 1978-08-28 | @ LAN | 131 | L 0-4 | 61-70 | 4 | 30,984 | Steve Rogers | Burt Hooton | Burt Hooton | Steve Rogers | | 515 | 482 | 33 |
| 1978-08-29 | @ LAN | 132 | L 1-4 | 61-71 | 4 | 37,179 | Hal Dues | Tommy John | Tommy John | Hal Dues | | 516 | 486 | 30 |
| 1978-08-30 | @ LAN | 133 | L 3-4 | 61-72 | 4 | 41,469 | Dan Schatzeder | Don Sutton | Charlie Hough | Wayne Twitchell | | 519 | 490 | 29 |
| 1978-08-31 | @ SDN | 134 | L 1-6 | 61-73 | 4 | 11,810 | Woodie Fryman | Eric Rasmussen | Eric Rasmussen | Woodie Fryman | Mark Lee | 520 | 496 | 24 |
| 1978-09-01 | @ SDN | 135 | W 3-2 | 62-73 | 4 | 14,346 | Ross Grimsley | Randy Jones | Mike Garman | Randy Jones | | 523 | 498 | 25 |
| 1978-09-02 | @ SDN | 136 | W 3-2 | 63-73 | 4 | 18,142 | Scott Sanderson | Mickey Lolich | Scott Sanderson | Mickey Lolich | Mike Garman | 526 | 500 | 26 |
| 1978-09-04 | @ CHN | 137 | W 5-3 | 65-73 | 4 | 0 | Dan Schatzeder | Ray Burris | Dan Schatzeder | Ray Burris | Darold Knowles | 531 | 503 | 28 |
| 1978-09-04 | @ CHN | 138 | W 6-5 | 65-73 | 4 | 29,833 | Rudy May | Mike Krukow | Mike Garman | Bruce Sutter | Bill Atkinson | 537 | 508 | 29 |
| 1978-09-05 | @ CHN | 139 | W 10-8 | 66-73 | 4 | 7,579 | Woodie Fryman | Donnie Moore | Wayne Twitchell | Bruce Sutter | Mike Garman | 547 | 516 | 31 |
| 1978-09-06 | vs NYN | 140 | W 8-2 | 67-73 | 4 | 7,894 | Ross Grimsley | Mike Bruhert | Ross Grimsley | Mike Bruhert | | 555 | 518 | 37 |
| 1978-09-07 | vs NYN | 141 | L 4-9 | 67-74 | 4 | 10,161 | Bob James | Nino Espinosa | Nino Espinosa | Bob James | | 559 | 527 | 32 |
| 1978-09-08 | vs CHN | 142 | L 2-4 | 67-75 | 4 | 11,621 | Scott Sanderson | Ray Burris | Bruce Sutter | Mike Garman | | 561 | 531 | 30 |
| 1978-09-09 | vs CHN | 143 | L 3-6 | 67-76 | 4 | 15,217 | Dan Schatzeder | Mike Krukow | Mike Krukow | Dan Schatzeder | Bruce Sutter | 564 | 537 | 27 |
| 1978-09-10 | vs CHN | 144 | L 3-6 | 67-77 | 4 | 14,772 | Woodie Fryman | Rick Reuschel | Rick Reuschel | Woodie Fryman | | 567 | 543 | 24 |
| 1978-09-11 | vs SLN | 145 | W 3-1 | 68-77 | 4 | 4,949 | Ross Grimsley | John Denny | Ross Grimsley | John Denny | | 570 | 544 | 26 |
| 1978-09-12 | vs SLN | 146 | W 5-1 | 69-77 | 4 | 8,672 | Rudy May | Pete Vuckovich | Rudy May | Pete Vuckovich | | 575 | 545 | 30 |
| 1978-09-13 | @ NYN | 147 | W 4-3 | 70-77 | 4 | 4,302 | Scott Sanderson | Nino Espinosa | Scott Sanderson | Nino Espinosa | Mike Garman | 579 | 548 | 31 |
| 1978-09-14 | @ NYN | 148 | L 6-7 | 70-78 | 4 | 3,710 | Dan Schatzeder | Kevin Kobel | Mardie Cornejo | Randy Miller | Dale Murray | 585 | 555 | 30 |
| 1978-09-15 | @ PIT | 149 | L 1-6 | 70-79 | 4 | 15,146 | Woodie Fryman | Bruce Kison | Bruce Kison | Woodie Fryman | | 586 | 561 | 25 |
| 1978-09-16 | @ PIT | 150 | L 5-12 | 70-80 | 4 | 8,079 | Ross Grimsley | Don Robinson | Don Robinson | Ross Grimsley | | 591 | 573 | 18 |
| 1978-09-17 | @ PIT | 151 | L 3-5 | 70-81 | 4 | 8,544 | Rudy May | Bert Blyleven | Bert Blyleven | Rudy May | Kent Tekulve | 594 | 578 | 16 |
| 1978-09-19 | vs PHI | 152 | W 5-2 | 71-81 | 4 | 9,429 | Scott Sanderson | Dick Ruthven | Scott Sanderson | Dick Ruthven | Mike Garman | 599 | 580 | 19 |
| 1978-09-20 | vs PHI | 153 | L 2-4 | 71-82 | 4 | 9,298 | Dan Schatzeder | Randy Lerch | Randy Lerch | Dan Schatzeder | Ron Reed | 601 | 584 | 17 |
| 1978-09-23 | vs PIT | 154 | W 3-2 | 72-82 | 4 | 20,324 | Ross Grimsley | Bert Blyleven | Ross Grimsley | Bert Blyleven | | 604 | 586 | 18 |
| 1978-09-24 | vs PIT | 155 | W 4-0 | 73-82 | 4 | 23,260 | Scott Sanderson | Bruce Kison | Scott Sanderson | Bruce Kison | | 608 | 586 | 22 |
| 1978-09-25 | @ PHI | 156 | L 2-3 | 73-83 | 4 | 11,651 | Dan Schatzeder | Randy Lerch | Ron Reed | Stan Bahnsen | | 610 | 589 | 21 |
| 1978-09-26 | @ PHI | 157 | L 3-5 | 74-84 | 4 | 0 | David Palmer | Jim Kaat | Jim Kaat | David Palmer | Ron Reed | 613 | 594 | 19 |
| 1978-09-26 | @ PHI | 158 | W 3-0 | 74-84 | 4 | 29,506 | Rudy May | Tug McGraw | Rudy May | Tug McGraw | | 616 | 594 | 22 |
| 1978-09-27 | @ PHI | 159 | L 4-5 | 74-85 | 4 | 27,410 | Ross Grimsley | Larry Christenson | Larry Christenson | Ross Grimsley | Ron Reed | 620 | 599 | 21 |
| 1978-09-29 | @ SLN | 160 | W 7-5 | 75-85 | 4 | 6,280 | Scott Sanderson | John Urrea | Darold Knowles | Buddy Schultz | Woodie Fryman | 627 | 604 | 23 |
| 1978-09-30 | @ SLN | 161 | L 1-6 | 75-86 | 4 | 4,504 | Dan Schatzeder | John Denny | John Denny | Dan Schatzeder | | 628 | 610 | 18 |
| 1978-10-01 | @ SLN | 162 | W 5-1 | 76-86 | 4 | 6,182 | Ross Grimsley | Pete Vuckovich | Ross Grimsley | Dan O'Brien | | 633 | 611 | 22 |