| 1978-04-05 | @ SEA | 1 | L 2-3 | 0-1 | 4 | 45,235 | Dave Goltz | Glenn Abbott | Glenn Abbott | Dave Goltz | Enrique Romo | 2 | 3 | -1 |
| 1978-04-06 | @ SEA | 2 | W 5-4 | 1-1 | 1 | 10,311 | Roger Erickson | Dick Pole | Roger Erickson | Dick Pole | Tom Johnson | 7 | 7 | 0 |
| 1978-04-07 | @ SEA | 3 | L 3-6 | 1-2 | 4 | 11,530 | Pete Redfern | Rick Honeycutt | Rick Honeycutt | Pete Redfern | Enrique Romo | 10 | 13 | -3 |
| 1978-04-08 | @ SEA | 4 | W 8-2 | 2-2 | 3 | 12,896 | Paul Thormodsgard | Paul Mitchell | Paul Thormodsgard | Paul Mitchell | | 18 | 15 | 3 |
| 1978-04-09 | @ SEA | 5 | W 8-6 | 3-2 | 3 | 11,803 | Geoff Zahn | Tom House | Gary Serum | Tom House | | 26 | 21 | 5 |
| 1978-04-10 | @ CAL | 6 | L 0-3 | 3-3 | 5 | 10,074 | Dave Goltz | Ken Brett | Ken Brett | Dave Goltz | | 26 | 24 | 2 |
| 1978-04-11 | @ CAL | 7 | W 8-1 | 4-3 | 5 | 12,217 | Roger Erickson | Don Aase | Roger Erickson | Don Aase | | 34 | 25 | 9 |
| 1978-04-12 | @ CAL | 8 | L 5-9 | 4-4 | 5 | 12,295 | Pete Redfern | Frank Tanana | Frank Tanana | Pete Redfern | Dave LaRoche | 39 | 34 | 5 |
| 1978-04-13 | @ CAL | 9 | L 0-1 | 4-5 | 5 | 11,702 | Paul Thormodsgard | Nolan Ryan | Dave LaRoche | Tom Johnson | | 39 | 35 | 4 |
| 1978-04-14 | vs SEA | 10 | W 14-5 | 5-5 | 5 | 17,425 | Geoff Zahn | Tom House | Geoff Zahn | Tom House | | 53 | 40 | 13 |
| 1978-04-15 | vs SEA | 11 | W 6-5 | 6-5 | 5 | 7,471 | Dave Goltz | Jim Todd | Tom Johnson | John Montague | | 59 | 45 | 14 |
| 1978-04-16 | vs SEA | 12 | L 5-8 | 6-7 | 5 | 0 | Roger Erickson | Dick Pole | Dick Pole | Roger Erickson | Shane Rawley | 64 | 53 | 11 |
| 1978-04-16 | vs SEA | 13 | L 2-7 | 6-7 | 5 | 14,021 | Dave Johnson | Tom House | Tom House | Dave Johnson | | 66 | 60 | 6 |
| 1978-04-17 | vs OAK | 14 | L 2-7 | 6-8 | 5 | 2,054 | Paul Thormodsgard | Pete Broberg | Pete Broberg | Paul Thormodsgard | | 68 | 67 | 1 |
| 1978-04-19 | vs OAK | 15 | L 5-6 | 6-9 | 5 | 1,935 | Geoff Zahn | Rick Langford | Elias Sosa | Tom Johnson | | 73 | 73 | 0 |
| 1978-04-21 | vs CAL | 16 | L 2-3 | 6-10 | 5 | 4,516 | Dave Goltz | Don Aase | Don Aase | Dave Goltz | Dave LaRoche | 75 | 76 | -1 |
| 1978-04-22 | vs CAL | 17 | L 3-5 | 6-11 | 5 | 6,566 | Roger Erickson | Frank Tanana | Frank Tanana | Roger Erickson | Paul Hartzell | 78 | 81 | -3 |
| 1978-04-25 | @ OAK | 18 | L 3-5 | 6-13 | 5 | 0 | Paul Thormodsgard | Pete Broberg | Elias Sosa | Greg Thayer | | 81 | 86 | -5 |
| 1978-04-25 | @ OAK | 19 | L 3-4 | 6-13 | 5 | 4,808 | Geoff Zahn | Rick Langford | Joe Coleman | Tom Johnson | | 84 | 90 | -6 |
| 1978-04-26 | @ OAK | 20 | L 8-9 | 6-14 | 7 | 4,127 | Roger Erickson | Matt Keough | Joe Coleman | Tom Johnson | | 92 | 99 | -7 |
| 1978-04-27 | @ OAK | 21 | W 6-1 | 7-14 | 6 | 4,645 | Gary Serum | Alan Wirth | Gary Serum | Alan Wirth | | 98 | 100 | -2 |
| 1978-04-28 | vs NYA | 22 | L 1-3 | 7-15 | 6 | 11,674 | Paul Thormodsgard | Ed Figueroa | Ed Figueroa | Paul Thormodsgard | | 99 | 103 | -4 |
| 1978-04-29 | vs NYA | 23 | W 3-1 | 8-15 | 6 | 10,543 | Geoff Zahn | Dick Tidrow | Geoff Zahn | Dick Tidrow | | 102 | 104 | -2 |
| 1978-04-30 | vs NYA | 24 | L 2-3 | 8-16 | 6 | 13,929 | Roger Erickson | Ron Guidry | Rich Gossage | Mac Scarce | | 104 | 107 | -3 |
| 1978-05-03 | @ BOS | 25 | L 9-11 | 8-17 | 6 | 16,403 | Gary Serum | Luis Tiant | Tom Burgmeier | Dave Johnson | Bob Stanley | 113 | 118 | -5 |
| 1978-05-04 | @ BOS | 26 | L 1-8 | 8-18 | 6 | 15,784 | Paul Thormodsgard | Dennis Eckersley | Dennis Eckersley | Paul Thormodsgard | | 114 | 126 | -12 |
| 1978-05-05 | @ BAL | 27 | L 1-2 | 8-19 | 7 | 3,897 | Geoff Zahn | Mike Flanagan | Mike Flanagan | Geoff Zahn | | 115 | 128 | -13 |
| 1978-05-06 | @ BAL | 28 | W 8-7 | 9-19 | 6 | 26,870 | Roger Erickson | Dennis Martinez | Greg Thayer | Don Stanhouse | Tom Johnson | 123 | 135 | -12 |
| 1978-05-07 | @ BAL | 29 | W 15-9 | 10-19 | 6 | 8,923 | Gary Serum | Jim Palmer | Mac Scarce | Jim Palmer | | 138 | 144 | -6 |
| 1978-05-09 | @ NYA | 30 | L 1-3 | 10-20 | 6 | 11,271 | Paul Thormodsgard | Catfish Hunter | Catfish Hunter | Paul Thormodsgard | Sparky Lyle | 139 | 147 | -8 |
| 1978-05-10 | @ CHA | 31 | L 2-7 | 10-21 | 7 | 8,338 | Roger Erickson | Rich Wortham | Rich Wortham | Roger Erickson | | 141 | 154 | -13 |
| 1978-05-13 | vs BOS | 32 | L 2-4 | 10-22 | 7 | 7,914 | Geoff Zahn | Mike Torrez | Mike Torrez | Geoff Zahn | Tom Burgmeier | 143 | 158 | -15 |
| 1978-05-14 | vs BOS | 33 | L 2-6 | 10-23 | 7 | 7,008 | Paul Thormodsgard | Dennis Eckersley | Dennis Eckersley | Paul Thormodsgard | Tom Burgmeier | 145 | 164 | -19 |
| 1978-05-15 | vs BAL | 34 | W 9-6 | 11-23 | 6 | 3,847 | Roger Erickson | Dennis Martinez | Mike Marshall | John Flinn | | 154 | 170 | -16 |
| 1978-05-16 | vs BAL | 35 | W 8-1 | 12-23 | 5 | 4,893 | Dave Goltz | Jim Palmer | Dave Goltz | Jim Palmer | Tom Johnson | 162 | 171 | -9 |
| 1978-05-18 | @ KCA | 36 | W 8-6 | 13-23 | 5 | 17,459 | Geoff Zahn | Dennis Leonard | Geoff Zahn | Dennis Leonard | Mike Marshall | 170 | 177 | -7 |
| 1978-05-19 | @ KCA | 37 | W 5-3 | 14-23 | 5 | 31,574 | Roger Erickson | Andy Hassler | Roger Erickson | Marty Pattin | Mike Marshall | 175 | 180 | -5 |
| 1978-05-20 | @ KCA | 38 | L 3-6 | 14-24 | 5 | 30,312 | Paul Thormodsgard | Rich Gale | Rich Gale | Paul Thormodsgard | Al Hrabosky | 178 | 186 | -8 |
| 1978-05-21 | @ KCA | 39 | W 3-2 | 15-24 | 5 | 29,079 | Gary Serum | Paul Splittorff | Gary Serum | Paul Splittorff | Mike Marshall | 181 | 188 | -7 |
| 1978-05-22 | vs TEX | 40 | W 2-0 | 16-24 | 5 | 6,108 | Geoff Zahn | Jon Matlack | Geoff Zahn | Jon Matlack | Mike Marshall | 183 | 188 | -5 |
| 1978-05-23 | vs TEX | 41 | W 5-2 | 17-24 | 5 | 6,791 | Roger Erickson | Jim Umbarger | Roger Erickson | Jim Umbarger | | 188 | 190 | -2 |
| 1978-05-24 | vs TEX | 42 | L 2-3 | 17-25 | 5 | 7,598 | Paul Thormodsgard | Dock Ellis | Paul Lindblad | Mike Marshall | Doc Medich | 190 | 193 | -3 |
| 1978-05-25 | vs TEX | 43 | L 1-7 | 17-26 | 5 | 7,644 | Gary Serum | Fergie Jenkins | Fergie Jenkins | Gary Serum | | 191 | 200 | -9 |
| 1978-05-28 | vs KCA | 44 | L 7-8 | 17-27 | 5 | 22,266 | Paul Thormodsgard | Andy Hassler | Larry Gura | Mike Marshall | | 198 | 208 | -10 |
| 1978-05-29 | @ TEX | 45 | L 1-7 | 18-28 | 5 | 0 | Gary Serum | Dock Ellis | Dock Ellis | Gary Serum | | 199 | 215 | -16 |
| 1978-05-29 | @ TEX | 46 | W 7-2 | 18-28 | 5 | 28,317 | Roger Erickson | Jim Umbarger | Roger Erickson | Jim Umbarger | Mike Marshall | 206 | 217 | -11 |
| 1978-05-30 | @ TEX | 47 | W 2-0 | 19-28 | 5 | 12,718 | Geoff Zahn | Fergie Jenkins | Geoff Zahn | Fergie Jenkins | Mike Marshall | 208 | 217 | -9 |
| 1978-06-01 | @ TEX | 48 | L 7-10 | 19-29 | 5 | 16,084 | Paul Thormodsgard | Doyle Alexander | Steve Comer | Mike Marshall | | 215 | 227 | -12 |
| 1978-06-02 | @ DET | 49 | W 4-2 | 20-29 | 5 | 21,127 | Roger Erickson | Jack Billingham | Roger Erickson | Jack Billingham | Mike Marshall | 219 | 229 | -10 |
| 1978-06-03 | @ DET | 50 | W 9-2 | 21-29 | 5 | 21,227 | Dave Goltz | Bob Sykes | Dave Goltz | Bob Sykes | | 228 | 231 | -3 |
| 1978-06-04 | @ DET | 51 | L 4-6 | 21-30 | 5 | 36,575 | Geoff Zahn | Steve Baker | Jack Morris | Geoff Zahn | | 232 | 237 | -5 |
| 1978-06-07 | vs CHA | 52 | L 3-8 | 21-31 | 6 | 6,627 | Roger Erickson | Ken Kravec | Ken Kravec | Roger Erickson | | 235 | 245 | -10 |
| 1978-06-08 | vs CHA | 53 | L 1-2 | 21-32 | 6 | 11,071 | Dave Goltz | Wilbur Wood | Wilbur Wood | Dave Goltz | Jim Willoughby | 236 | 247 | -11 |
| 1978-06-09 | @ CLE | 54 | L 3-7 | 21-33 | 6 | 8,390 | Geoff Zahn | David Clyde | David Clyde | Geoff Zahn | Jim Kern | 239 | 254 | -15 |
| 1978-06-10 | @ CLE | 55 | L 3-4 | 21-34 | 6 | 16,048 | Roger Erickson | Rick Wise | Rick Wise | Mike Marshall | Jim Kern | 242 | 258 | -16 |
| 1978-06-11 | @ CLE | 56 | L 1-2 | 21-35 | 6 | 25,547 | Gary Serum | Don Hood | Mike Paxton | Mike Marshall | | 243 | 260 | -17 |
| 1978-06-13 | @ TOR | 57 | W 2-0 | 23-35 | 6 | 0 | Dave Goltz | Balor Moore | Dave Goltz | Balor Moore | Mike Marshall | 245 | 260 | -15 |
| 1978-06-13 | @ TOR | 58 | W 7-2 | 23-35 | 6 | 14,489 | Geoff Zahn | Jim Clancy | Geoff Zahn | Jim Clancy | | 252 | 262 | -10 |
| 1978-06-14 | vs CLE | 59 | W 8-2 | 24-35 | 6 | 6,612 | Roger Erickson | David Clyde | Roger Erickson | David Clyde | | 260 | 264 | -4 |
| 1978-06-16 | vs DET | 60 | W 5-2 | 25-35 | 6 | 9,479 | Darrell Jackson | Dave Rozema | Darrell Jackson | Dave Rozema | | 265 | 266 | -1 |
| 1978-06-17 | vs DET | 61 | W 3-1 | 26-35 | 6 | 9,807 | Geoff Zahn | Milt Wilcox | Geoff Zahn | Milt Wilcox | | 268 | 267 | 1 |
| 1978-06-18 | vs DET | 62 | W 8-4 | 27-35 | 6 | 21,480 | Dave Goltz | Jim Slaton | Dave Goltz | Jim Slaton | Mike Marshall | 276 | 271 | 5 |
| 1978-06-20 | vs CAL | 63 | L 5-10 | 27-36 | 6 | 12,330 | Roger Erickson | Frank Tanana | Frank Tanana | Roger Erickson | | 281 | 281 | 0 |
| 1978-06-21 | vs CAL | 64 | L 2-5 | 27-37 | 6 | 10,801 | Geoff Zahn | Don Aase | Don Aase | Geoff Zahn | | 283 | 286 | -3 |
| 1978-06-22 | vs CAL | 65 | L 2-4 | 27-38 | 6 | 7,488 | Gary Serum | Ken Brett | Dave LaRoche | Mike Marshall | | 285 | 290 | -5 |
| 1978-06-23 | @ CHA | 66 | W 2-1 | 28-38 | 6 | 28,082 | Dave Goltz | Ken Kravec | Dave Goltz | Ken Kravec | | 287 | 291 | -4 |
| 1978-06-24 | @ CHA | 67 | L 4-7 | 28-39 | 6 | 27,433 | Darrell Jackson | Wilbur Wood | Wilbur Wood | Darrell Jackson | Lerrin LaGrow | 291 | 298 | -7 |
| 1978-06-25 | @ CHA | 68 | W 8-5 | 30-39 | 6 | 0 | Geoff Zahn | Steve Stone | Mike Marshall | Ron Schueler | | 299 | 303 | -4 |
| 1978-06-25 | @ CHA | 69 | W 9-6 | 30-39 | 6 | 20,137 | Roger Erickson | Rich Hinton | Roger Erickson | Rich Hinton | Mike Marshall | 308 | 309 | -1 |
| 1978-06-26 | @ MIL | 70 | L 2-8 | 30-40 | 6 | 7,988 | Gary Serum | Lary Sorensen | Lary Sorensen | Gary Serum | | 310 | 317 | -7 |
| 1978-06-27 | @ MIL | 71 | L 6-13 | 30-41 | 6 | 16,137 | Dave Goltz | Moose Haas | Andy Replogle | Dave Goltz | | 316 | 330 | -14 |
| 1978-07-01 | vs CHA | 72 | W 10-0 | 31-41 | 6 | 7,533 | Dave Goltz | Francisco Barrios | Dave Goltz | Francisco Barrios | | 326 | 330 | -4 |
| 1978-07-02 | vs CHA | 73 | L 5-8 | 32-42 | 6 | 0 | Geoff Zahn | Wilbur Wood | Wilbur Wood | Geoff Zahn | Jim Willoughby | 331 | 338 | -7 |
| 1978-07-02 | vs CHA | 74 | W 9-5 | 32-42 | 6 | 26,897 | Darrell Jackson | Ron Schueler | Mike Marshall | Ron Schueler | | 340 | 343 | -3 |
| 1978-07-03 | vs MIL | 75 | W 7-2 | 33-42 | 6 | 19,062 | Roger Erickson | Jerry Augustine | Roger Erickson | Jerry Augustine | | 347 | 345 | 2 |
| 1978-07-04 | vs MIL | 76 | W 7-2 | 34-42 | 6 | 26,263 | Gary Serum | Bill Travers | Gary Serum | Bill Travers | | 354 | 347 | 7 |
| 1978-07-05 | vs MIL | 77 | W 3-1 | 35-42 | 6 | 11,409 | Dave Goltz | Lary Sorensen | Dave Goltz | Lary Sorensen | | 357 | 348 | 9 |
| 1978-07-07 | @ OAK | 78 | W 3-2 | 37-42 | 5 | 0 | Geoff Zahn | Steve Renko | Geoff Zahn | Steve Renko | Mike Marshall | 360 | 350 | 10 |
| 1978-07-07 | @ OAK | 79 | W 1-0 | 37-42 | 5 | 7,239 | Darrell Jackson | Rick Langford | Darrell Jackson | Rick Langford | | 361 | 350 | 11 |
| 1978-07-08 | @ OAK | 80 | W 9-8 | 38-42 | 5 | 12,201 | Roger Erickson | Pete Broberg | Mike Marshall | Dave Heaverlo | | 370 | 358 | 12 |
| 1978-07-09 | @ OAK | 81 | W 7-0 | 39-42 | 5 | 4,720 | Dave Goltz | Pete Broberg | Dave Goltz | Pete Broberg | | 377 | 358 | 19 |
| 1978-07-13 | @ BAL | 82 | L 6-8 | 39-43 | 5 | 8,119 | Dave Goltz | Mike Flanagan | Mike Flanagan | Dave Goltz | Tippy Martinez | 383 | 366 | 17 |
| 1978-07-14 | @ BAL | 83 | L 1-5 | 39-44 | 5 | 24,195 | Geoff Zahn | Scott McGregor | Scott McGregor | Geoff Zahn | | 384 | 371 | 13 |
| 1978-07-15 | @ BOS | 84 | L 4-5 | 39-45 | 5 | 32,861 | Darrell Jackson | Bill Lee | Bill Lee | Darrell Jackson | Bob Stanley | 388 | 376 | 12 |
| 1978-07-16 | @ BOS | 85 | L 3-5 | 39-47 | 5 | 0 | Gary Serum | Dennis Eckersley | Dennis Eckersley | Roric Harrison | Bill Campbell | 391 | 381 | 10 |
| 1978-07-16 | @ BOS | 86 | L 2-3 | 39-47 | 5 | 35,589 | Roger Erickson | Jim Wright | Jim Wright | Roger Erickson | Bob Stanley | 393 | 384 | 9 |
| 1978-07-17 | @ BOS | 87 | L 2-3 | 39-48 | 5 | 33,233 | Dave Goltz | Luis Tiant | Bill Campbell | Mike Marshall | | 395 | 387 | 8 |
| 1978-07-19 | vs NYA | 88 | L 0-2 | 39-49 | 5 | 29,591 | Geoff Zahn | Ed Figueroa | Ed Figueroa | Geoff Zahn | | 395 | 389 | 6 |
| 1978-07-20 | vs NYA | 89 | L 0-4 | 39-50 | 5 | 30,660 | Darrell Jackson | Ron Guidry | Ron Guidry | Darrell Jackson | | 395 | 393 | 2 |
| 1978-07-21 | vs BAL | 90 | L 4-5 | 39-51 | 5 | 14,702 | Roger Erickson | Mike Flanagan | Don Stanhouse | Mike Marshall | | 399 | 398 | 1 |
| 1978-07-22 | vs BAL | 91 | W 5-4 | 40-51 | 5 | 10,063 | Dave Goltz | Scott McGregor | Dave Goltz | Scott McGregor | | 404 | 402 | 2 |
| 1978-07-23 | vs BAL | 92 | L 5-8 | 40-52 | 5 | 30,896 | Gary Serum | Jim Palmer | Jim Palmer | Gary Serum | Don Stanhouse | 409 | 410 | -1 |
| 1978-07-24 | vs BOS | 93 | W 5-4 | 41-53 | 5 | 0 | Darrell Jackson | Tom Burgmeier | Darrell Jackson | Dick Drago | Mike Marshall | 414 | 414 | 0 |
| 1978-07-24 | vs BOS | 94 | L 2-4 | 41-53 | 5 | 21,580 | Geoff Zahn | Mike Torrez | Andy Hassler | Geoff Zahn | Bob Stanley | 416 | 418 | -2 |
| 1978-07-25 | vs BOS | 95 | W 5-2 | 42-53 | 5 | 18,608 | Roger Erickson | Bill Lee | Roger Erickson | Bill Lee | Mike Marshall | 421 | 420 | 1 |
| 1978-07-26 | vs TOR | 96 | L 1-5 | 42-54 | 5 | 6,014 | Dave Goltz | Balor Moore | Balor Moore | Dave Goltz | | 422 | 425 | -3 |
| 1978-07-27 | vs TOR | 97 | W 6-3 | 43-54 | 5 | 18,285 | Stan Perzanowski | Jim Clancy | Stan Perzanowski | Jim Clancy | | 428 | 428 | 0 |
| 1978-07-28 | @ NYA | 98 | W 7-5 | 44-54 | 5 | 25,037 | Geoff Zahn | Dick Tidrow | Mike Marshall | Sparky Lyle | | 435 | 433 | 2 |
| 1978-07-29 | @ NYA | 99 | L 3-7 | 44-55 | 5 | 46,711 | Darrell Jackson | Ken Clay | Ken Clay | Darrell Jackson | Rich Gossage | 438 | 440 | -2 |
| 1978-07-30 | @ NYA | 100 | L 3-4 | 45-56 | 5 | 0 | Roger Erickson | Ron Guidry | Rich Gossage | Mike Marshall | | 441 | 444 | -3 |
| 1978-07-30 | @ NYA | 101 | W 2-0 | 45-56 | 5 | 41,491 | Dave Goltz | Jim Beattie | Dave Goltz | Jim Beattie | Mike Marshall | 443 | 444 | -1 |
| 1978-08-01 | @ SEA | 102 | L 6-13 | 45-57 | 5 | 9,272 | Stan Perzanowski | Paul Mitchell | Tom House | Stan Perzanowski | | 449 | 457 | -8 |
| 1978-08-02 | @ SEA | 103 | L 1-3 | 45-58 | 5 | 8,394 | Geoff Zahn | Jim Colborn | Jim Colborn | Geoff Zahn | | 450 | 460 | -10 |
| 1978-08-03 | @ SEA | 104 | L 5-6 | 45-59 | 5 | 9,471 | Darrell Jackson | Rick Honeycutt | Enrique Romo | Mike Marshall | | 455 | 466 | -11 |
| 1978-08-04 | @ CAL | 105 | L 3-12 | 45-60 | 5 | 17,411 | Dave Goltz | Al Fitzmorris | Al Fitzmorris | Gary Serum | Ken Brett | 458 | 478 | -20 |
| 1978-08-05 | @ CAL | 106 | W 4-3 | 46-61 | 5 | 0 | Roger Erickson | Frank Tanana | Roger Erickson | Frank Tanana | | 462 | 481 | -19 |
| 1978-08-05 | @ CAL | 107 | L 3-4 | 46-61 | 5 | 41,723 | Stan Perzanowski | Chris Knapp | Chris Knapp | Stan Perzanowski | Dave LaRoche | 465 | 485 | -20 |
| 1978-08-06 | @ CAL | 108 | L 3-4 | 46-62 | 5 | 17,628 | Geoff Zahn | Nolan Ryan | Dave LaRoche | Mike Marshall | | 468 | 489 | -21 |
| 1978-08-07 | vs SEA | 109 | L 5-6 | 46-63 | 6 | 6,657 | Darrell Jackson | Jim Colborn | Jim Todd | Stan Perzanowski | | 473 | 495 | -22 |
| 1978-08-08 | vs SEA | 110 | W 10-2 | 47-63 | 5 | 6,499 | Gary Serum | Rick Honeycutt | Gary Serum | Rick Honeycutt | | 483 | 497 | -14 |
| 1978-08-09 | vs SEA | 111 | L 1-4 | 47-64 | 5 | 6,814 | Roger Erickson | Glenn Abbott | Glenn Abbott | Roger Erickson | Jim Todd | 484 | 501 | -17 |
| 1978-08-11 | vs OAK | 112 | L 0-2 | 48-65 | 5 | 0 | Geoff Zahn | Rick Langford | Rick Langford | Geoff Zahn | | 484 | 503 | -19 |
| 1978-08-11 | vs OAK | 113 | W 3-2 | 48-65 | 5 | 13,795 | Darrell Jackson | Pete Broberg | Darrell Jackson | Pete Broberg | Mike Marshall | 487 | 505 | -18 |
| 1978-08-12 | vs OAK | 114 | W 6-3 | 49-65 | 5 | 11,740 | Stan Perzanowski | Steve Renko | Stan Perzanowski | Steve Renko | Mike Marshall | 493 | 508 | -15 |
| 1978-08-13 | vs OAK | 115 | W 3-1 | 51-65 | 5 | 0 | Gary Serum | Matt Keough | Gary Serum | Matt Keough | | 496 | 509 | -13 |
| 1978-08-13 | vs OAK | 116 | W 2-1 | 51-65 | 5 | 18,577 | Roger Erickson | Mike Norris | Roger Erickson | Mike Norris | | 498 | 510 | -12 |
| 1978-08-14 | @ CLE | 117 | L 3-4 | 51-66 | 5 | 6,513 | Jeff Holly | Mike Paxton | Mike Paxton | Jeff Holly | Jim Kern | 501 | 514 | -13 |
| 1978-08-15 | @ CLE | 118 | W 9-8 | 52-66 | 5 | 6,971 | Darrell Jackson | Rick Waits | Mike Marshall | Sid Monge | Gary Serum | 510 | 522 | -12 |
| 1978-08-16 | vs KCA | 119 | W 5-1 | 53-67 | 5 | 0 | Geoff Zahn | Doug Bird | Geoff Zahn | Doug Bird | | 515 | 523 | -8 |
| 1978-08-16 | vs KCA | 120 | L 7-11 | 53-67 | 5 | 14,640 | Stan Perzanowski | Paul Splittorff | Paul Splittorff | Stan Perzanowski | Steve Mingori | 522 | 534 | -12 |
| 1978-08-17 | vs KCA | 121 | W 6-5 | 54-67 | 5 | 15,936 | Roger Erickson | Larry Gura | Roger Erickson | Larry Gura | | 528 | 539 | -11 |
| 1978-08-18 | vs TOR | 122 | W 4-3 | 55-67 | 5 | 4,599 | Dave Goltz | Tom Underwood | Jeff Holly | Tom Murphy | | 532 | 542 | -10 |
| 1978-08-19 | vs TOR | 123 | W 5-0 | 56-67 | 5 | 10,745 | Gary Serum | Jerry Garvin | Gary Serum | Jerry Garvin | | 537 | 542 | -5 |
| 1978-08-20 | vs TOR | 124 | L 2-6 | 56-68 | 5 | 11,685 | Stan Perzanowski | Don Kirkwood | Don Kirkwood | Stan Perzanowski | Tom Murphy | 539 | 548 | -9 |
| 1978-08-21 | vs DET | 125 | L 6-9 | 56-69 | 5 | 7,419 | Geoff Zahn | Jack Billingham | Jack Billingham | Geoff Zahn | | 545 | 557 | -12 |
| 1978-08-22 | vs DET | 126 | L 3-7 | 56-70 | 5 | 7,726 | Darrell Jackson | Jim Slaton | Jim Slaton | Stan Perzanowski | | 548 | 564 | -16 |
| 1978-08-23 | vs TEX | 127 | L 0-2 | 56-71 | 5 | 7,157 | Roger Erickson | Steve Comer | Steve Comer | Roger Erickson | | 548 | 566 | -18 |
| 1978-08-24 | vs TEX | 128 | L 1-4 | 56-72 | 5 | 8,666 | Dave Goltz | Fergie Jenkins | Fergie Jenkins | Dave Goltz | | 549 | 570 | -21 |
| 1978-08-25 | @ TOR | 129 | L 3-7 | 56-73 | 5 | 15,206 | Gary Serum | Don Kirkwood | Don Kirkwood | Gary Serum | Mike Willis | 552 | 577 | -25 |
| 1978-08-26 | @ TOR | 130 | L 3-4 | 56-74 | 5 | 25,601 | Geoff Zahn | Jesse Jefferson | Victor Cruz | Geoff Zahn | | 555 | 581 | -26 |
| 1978-08-27 | @ TOR | 131 | W 3-2 | 57-74 | 5 | 22,023 | Roger Erickson | Jim Clancy | Mike Marshall | Mike Willis | | 558 | 583 | -25 |
| 1978-08-29 | @ DET | 132 | L 2-4 | 57-75 | 5 | 13,839 | Dave Goltz | Milt Wilcox | Milt Wilcox | Dave Goltz | | 560 | 587 | -27 |
| 1978-08-31 | @ DET | 133 | W 4-1 | 58-75 | 5 | 16,995 | Geoff Zahn | Kip Young | Geoff Zahn | Kip Young | Mike Marshall | 564 | 588 | -24 |
| 1978-09-01 | vs CLE | 134 | L 1-4 | 58-76 | 5 | 4,917 | Roger Erickson | David Clyde | David Clyde | Roger Erickson | Dan Spillner | 565 | 592 | -27 |
| 1978-09-02 | vs CLE | 135 | W 2-1 | 59-76 | 5 | 6,775 | Dave Goltz | Paul Reuschel | Dave Goltz | Paul Reuschel | Mike Marshall | 567 | 593 | -26 |
| 1978-09-03 | vs CLE | 136 | W 12-3 | 61-76 | 5 | 0 | Gary Serum | Rick Wise | Gary Serum | Rick Wise | | 579 | 596 | -17 |
| 1978-09-03 | vs CLE | 137 | W 4-3 | 61-76 | 5 | 10,240 | Stan Perzanowski | Dave Freisleben | Mike Marshall | Jim Kern | | 583 | 599 | -16 |
| 1978-09-04 | vs CHA | 138 | W 2-1 | 62-76 | 5 | 6,978 | Geoff Zahn | Francisco Barrios | Geoff Zahn | Francisco Barrios | | 585 | 600 | -15 |
| 1978-09-05 | vs CHA | 139 | L 3-4 | 62-77 | 5 | 3,630 | Roger Erickson | Steve Trout | Steve Trout | Roger Erickson | Lerrin LaGrow | 588 | 604 | -16 |
| 1978-09-06 | vs CHA | 140 | L 0-1 | 62-78 | 5 | 3,648 | Dave Goltz | Ken Kravec | Ken Kravec | Dave Goltz | | 588 | 605 | -17 |
| 1978-09-08 | vs MIL | 141 | L 0-3 | 62-79 | 5 | 9,262 | Gary Serum | Andy Replogle | Andy Replogle | Gary Serum | | 588 | 608 | -20 |
| 1978-09-09 | vs MIL | 142 | L 0-3 | 62-80 | 5 | 10,639 | Roger Erickson | Mike Caldwell | Mike Caldwell | Roger Erickson | | 588 | 611 | -23 |
| 1978-09-10 | vs MIL | 143 | W 3-1 | 63-80 | 5 | 10,512 | Dave Goltz | Bill Travers | Dave Goltz | Bill Travers | | 591 | 612 | -21 |
| 1978-09-11 | @ CHA | 144 | W 3-1 | 64-80 | 5 | 7,342 | Geoff Zahn | Ken Kravec | Geoff Zahn | Ken Kravec | Mike Marshall | 594 | 613 | -19 |
| 1978-09-12 | @ CHA | 145 | L 1-6 | 64-81 | 5 | 6,279 | Gary Serum | Rich Hinton | Rich Hinton | Gary Serum | | 595 | 619 | -24 |
| 1978-09-15 | @ MIL | 146 | W 10-3 | 65-81 | 5 | 12,496 | Roger Erickson | Bill Travers | Roger Erickson | Bill Travers | | 605 | 622 | -17 |
| 1978-09-16 | @ MIL | 147 | W 5-2 | 66-81 | 4 | 37,809 | Dave Goltz | Lary Sorensen | Dave Goltz | Lary Sorensen | Mike Marshall | 610 | 624 | -14 |
| 1978-09-17 | @ MIL | 148 | W 4-3 | 67-81 | 4 | 11,007 | Gary Serum | Andy Replogle | Gary Serum | Andy Replogle | Mike Marshall | 614 | 627 | -13 |
| 1978-09-18 | vs CAL | 149 | W 10-4 | 68-81 | 4 | 2,278 | Geoff Zahn | Chris Knapp | Geoff Zahn | Chris Knapp | Stan Perzanowski | 624 | 631 | -7 |
| 1978-09-19 | vs CAL | 150 | L 1-4 | 68-82 | 4 | 3,747 | Roger Erickson | Nolan Ryan | Nolan Ryan | Roger Erickson | | 625 | 635 | -10 |
| 1978-09-20 | vs TEX | 151 | W 5-3 | 69-82 | 4 | 2,736 | Dave Goltz | Steve Comer | Dave Goltz | Steve Comer | | 630 | 638 | -8 |
| 1978-09-21 | vs TEX | 152 | L 3-6 | 69-83 | 4 | 3,312 | Gary Serum | Jon Matlack | Jon Matlack | Gary Serum | | 633 | 644 | -11 |
| 1978-09-22 | vs KCA | 153 | L 2-4 | 70-84 | 4 | 0 | Darrell Jackson | Larry Gura | Larry Gura | Darrell Jackson | | 635 | 648 | -13 |
| 1978-09-22 | vs KCA | 154 | W 4-0 | 70-84 | 4 | 5,175 | Geoff Zahn | Marty Pattin | Geoff Zahn | Marty Pattin | | 639 | 648 | -9 |
| 1978-09-23 | vs KCA | 155 | L 1-3 | 70-85 | 4 | 13,288 | Roger Erickson | Paul Splittorff | Paul Splittorff | Roger Erickson | Al Hrabosky | 640 | 651 | -11 |
| 1978-09-24 | vs KCA | 156 | W 6-4 | 71-85 | 4 | 6,627 | Dave Goltz | Rich Gale | Dave Goltz | Steve Mingori | | 646 | 655 | -9 |
| 1978-09-25 | @ TEX | 157 | L 2-3 | 71-86 | 4 | 6,404 | Gary Serum | Jon Matlack | Reggie Cleveland | Mike Marshall | | 648 | 658 | -10 |
| 1978-09-26 | @ TEX | 158 | W 6-2 | 72-86 | 4 | 6,797 | Geoff Zahn | Doc Medich | Mike Marshall | Paul Mirabella | | 654 | 660 | -6 |
| 1978-09-27 | @ TEX | 159 | L 5-10 | 72-87 | 4 | 9,601 | Roger Erickson | Fergie Jenkins | Paul Mirabella | Stan Perzanowski | | 659 | 670 | -11 |
| 1978-09-29 | @ KCA | 160 | L 0-4 | 72-88 | 4 | 31,794 | Darrell Jackson | Dennis Leonard | Dennis Leonard | Darrell Jackson | | 659 | 674 | -15 |
| 1978-09-30 | @ KCA | 161 | W 7-3 | 73-88 | 4 | 29,089 | Gary Serum | Steve Busby | Mike Marshall | Randy McGilberry | | 666 | 677 | -11 |
| 1978-10-01 | @ KCA | 162 | L 0-1 | 73-89 | 4 | 23,794 | Geoff Zahn | Larry Gura | George Throop | Geoff Zahn | Bill Paschall | 666 | 678 | -12 |