| 1978-04-07 | vs BAL | 1 | W 11-3 | - | | 47,824 | Jerry Augustine | Mike Flanagan | Jerry Augustine | Mike Flanagan | | 11 | 3 | 8 |
| 1978-04-08 | vs BAL | 2 | W 16-3 | - | | 6,470 | Moose Haas | Dennis Martinez | Moose Haas | Dennis Martinez | | 27 | 6 | 21 |
| 1978-04-09 | vs BAL | 3 | W 13-5 | - | | 18,514 | Lary Sorensen | Scott McGregor | Lary Sorensen | Scott McGregor | | 40 | 11 | 29 |
| 1978-04-11 | vs NYA | 4 | W 9-6 | - | | 8,934 | Jerry Augustine | Catfish Hunter | Jerry Augustine | Catfish Hunter | Mike Caldwell | 49 | 17 | 32 |
| 1978-04-12 | vs NYA | 5 | W 5-3 | - | | 8,751 | Moose Haas | Ken Holtzman | Moose Haas | Rich Gossage | | 54 | 20 | 34 |
| 1978-04-14 | @ BAL | 6 | L 5-6 | - | | 36,086 | Lary Sorensen | Dennis Martinez | Dennis Martinez | Lary Sorensen | Don Stanhouse | 59 | 26 | 33 |
| 1978-04-15 | @ BAL | 7 | L 0-7 | - | | 7,527 | Jerry Augustine | Jim Palmer | Jim Palmer | Jerry Augustine | | 59 | 33 | 26 |
| 1978-04-16 | @ BAL | 8 | L 5-7 | - | | 0 | Moose Haas | Nelson Briles | Nelson Briles | Moose Haas | Don Stanhouse | 64 | 40 | 24 |
| 1978-04-16 | @ BAL | 9 | W 9-2 | - | | 14,995 | Andy Replogle | Scott McGregor | Andy Replogle | Scott McGregor | Eduardo Rodriguez | 73 | 42 | 31 |
| 1978-04-17 | @ BOS | 10 | L 2-9 | - | | 26,075 | Randy Stein | Mike Torrez | Mike Torrez | Randy Stein | | 75 | 51 | 24 |
| 1978-04-18 | @ BOS | 11 | L 6-7 | - | | 18,928 | Lary Sorensen | Dennis Eckersley | Luis Tiant | Eduardo Rodriguez | | 81 | 58 | 23 |
| 1978-04-20 | @ BOS | 12 | L 4-10 | - | | 16,238 | Moose Haas | Bill Lee | Bill Lee | Moose Haas | | 85 | 68 | 17 |
| 1978-04-21 | @ NYA | 13 | W 9-2 | - | | 15,105 | Jerry Augustine | Ed Figueroa | Jerry Augustine | Ed Figueroa | | 94 | 70 | 24 |
| 1978-04-22 | @ NYA | 14 | L 3-4 | - | | 17,594 | Mike Caldwell | Dick Tidrow | Sparky Lyle | Bob McClure | | 97 | 74 | 23 |
| 1978-04-23 | @ NYA | 15 | W 3-2 | - | | 26,291 | Lary Sorensen | Catfish Hunter | Lary Sorensen | Catfish Hunter | Bob McClure | 100 | 76 | 24 |
| 1978-04-25 | vs BOS | 16 | L 3-4 | - | | 9,051 | Jerry Augustine | Bill Lee | Bill Lee | Jerry Augustine | Dick Drago | 103 | 80 | 23 |
| 1978-04-26 | vs BOS | 17 | W 6-4 | - | | 8,724 | Mike Caldwell | Mike Torrez | Mike Caldwell | Mike Torrez | Bob McClure | 109 | 84 | 25 |
| 1978-04-28 | @ KCA | 18 | L 6-7 | - | | 20,166 | Lary Sorensen | Steve Busby | Jim Colborn | Eduardo Rodriguez | Marty Pattin | 115 | 91 | 24 |
| 1978-04-29 | @ KCA | 19 | L 2-11 | - | | 27,521 | Jerry Augustine | Dennis Leonard | Dennis Leonard | Jerry Augustine | | 117 | 102 | 15 |
| 1978-04-30 | @ KCA | 20 | L 0-3 | - | | 19,827 | Mike Caldwell | Rich Gale | Rich Gale | Mike Caldwell | Steve Mingori | 117 | 105 | 12 |
| 1978-05-02 | vs CHA | 21 | L 3-5 | - | | 7,880 | Lary Sorensen | Wilbur Wood | Wilbur Wood | Lary Sorensen | | 120 | 110 | 10 |
| 1978-05-03 | vs CHA | 22 | W 4-0 | - | | 5,720 | Jerry Augustine | Rich Wortham | Jerry Augustine | Rich Wortham | | 124 | 110 | 14 |
| 1978-05-05 | vs KCA | 23 | W 9-0 | - | | 10,435 | Mike Caldwell | Jim Colborn | Mike Caldwell | Jim Colborn | | 133 | 110 | 23 |
| 1978-05-06 | vs KCA | 24 | W 4-3 | - | | 13,914 | Lary Sorensen | Paul Splittorff | Lary Sorensen | Doug Bird | | 137 | 113 | 24 |
| 1978-05-07 | vs KCA | 25 | L 6-8 | - | | 10,887 | Jerry Augustine | Rich Gale | Rich Gale | Jerry Augustine | Steve Mingori | 143 | 121 | 22 |
| 1978-05-09 | vs TEX | 26 | L 1-7 | - | | 4,790 | Mike Caldwell | Fergie Jenkins | Fergie Jenkins | Mike Caldwell | | 144 | 128 | 16 |
| 1978-05-10 | vs TEX | 27 | L 3-4 | - | | 6,528 | Lary Sorensen | Doyle Alexander | Doyle Alexander | Lary Sorensen | Reggie Cleveland | 147 | 132 | 15 |
| 1978-05-12 | @ CHA | 28 | L 3-4 | - | | 17,953 | Jerry Augustine | Wilbur Wood | Wilbur Wood | Jerry Augustine | Jim Willoughby | 150 | 136 | 14 |
| 1978-05-13 | @ CHA | 29 | W 6-1 | - | | 13,521 | Andy Replogle | Steve Stone | Andy Replogle | Steve Stone | | 156 | 137 | 19 |
| 1978-05-14 | @ CHA | 30 | W 5-4 | - | | 12,505 | Mike Caldwell | Francisco Barrios | Mike Caldwell | Francisco Barrios | | 161 | 141 | 20 |
| 1978-05-15 | @ TEX | 31 | L 6-8 | - | | 11,622 | Bill Travers | Fergie Jenkins | Fergie Jenkins | Bill Travers | Reggie Cleveland | 167 | 149 | 18 |
| 1978-05-16 | @ TEX | 32 | W 4-3 | - | | 11,351 | Lary Sorensen | Doyle Alexander | Lary Sorensen | Doyle Alexander | | 171 | 152 | 19 |
| 1978-05-17 | vs DET | 33 | L 3-5 | - | | 10,004 | Jerry Augustine | Jack Billingham | Jack Billingham | Jerry Augustine | John Hiller | 174 | 157 | 17 |
| 1978-05-18 | vs DET | 34 | W 8-7 | - | | 15,217 | Andy Replogle | Jack Morris | Bill Castro | Steve Foucault | | 182 | 164 | 18 |
| 1978-05-19 | vs CAL | 35 | L 1-7 | - | | 13,843 | Mike Caldwell | Frank Tanana | Frank Tanana | Mike Caldwell | | 183 | 171 | 12 |
| 1978-05-20 | vs CAL | 36 | W 6-4 | - | | 18,916 | Bill Travers | Ken Brett | Bill Travers | Ken Brett | Bill Castro | 189 | 175 | 14 |
| 1978-05-21 | vs CAL | 37 | W 2-1 | - | | 42,376 | Lary Sorensen | Don Aase | Lary Sorensen | Dave LaRoche | | 191 | 176 | 15 |
| 1978-05-23 | @ OAK | 38 | W 3-2 | - | | 2,534 | Jerry Augustine | Matt Keough | Jerry Augustine | Matt Keough | | 194 | 178 | 16 |
| 1978-05-24 | @ OAK | 39 | W 7-1 | - | | 2,257 | Mike Caldwell | Pete Broberg | Mike Caldwell | Pete Broberg | | 201 | 179 | 22 |
| 1978-05-26 | @ CAL | 40 | L 5-6 | - | | 19,277 | Bill Travers | Don Aase | Paul Hartzell | Eduardo Rodriguez | | 206 | 185 | 21 |
| 1978-05-27 | @ CAL | 41 | W 4-2 | - | | 29,097 | Lary Sorensen | Tom Griffin | Lary Sorensen | Tom Griffin | | 210 | 187 | 23 |
| 1978-05-28 | @ CAL | 42 | W 6-3 | - | | 21,869 | Andy Replogle | Nolan Ryan | Andy Replogle | Nolan Ryan | Bob McClure | 216 | 190 | 26 |
| 1978-05-29 | vs OAK | 43 | L 2-6 | - | | 18,665 | Jerry Augustine | Pete Broberg | Pete Broberg | Jerry Augustine | | 218 | 196 | 22 |
| 1978-05-30 | vs OAK | 44 | W 2-1 | - | | 8,322 | Mike Caldwell | Alan Wirth | Mike Caldwell | Elias Sosa | | 220 | 197 | 23 |
| 1978-05-31 | @ DET | 45 | L 0-3 | - | | 13,017 | Bill Travers | Milt Wilcox | Milt Wilcox | Bill Travers | | 220 | 200 | 20 |
| 1978-06-01 | @ DET | 46 | L 3-4 | - | | 11,614 | Lary Sorensen | Jim Slaton | Jim Slaton | Lary Sorensen | John Hiller | 223 | 204 | 19 |
| 1978-06-02 | vs CLE | 47 | L 6-7 | - | | 16,779 | Andy Replogle | David Clyde | Jim Kern | Bob McClure | | 229 | 211 | 18 |
| 1978-06-03 | vs CLE | 48 | L 4-6 | - | | 11,933 | Jerry Augustine | Mike Paxton | Mike Paxton | Jerry Augustine | Sid Monge | 233 | 217 | 16 |
| 1978-06-04 | vs CLE | 49 | W 12-7 | - | | 0 | Mike Caldwell | Rick Wise | Randy Stein | Rick Wise | | 245 | 224 | 21 |
| 1978-06-04 | vs CLE | 50 | W 9-4 | - | | 23,850 | Bill Travers | Don Hood | Bill Travers | Don Hood | Bill Castro | 254 | 228 | 26 |
| 1978-06-06 | vs DET | 51 | W 5-1 | - | | 13,022 | Lary Sorensen | Milt Wilcox | Lary Sorensen | Milt Wilcox | | 259 | 229 | 30 |
| 1978-06-07 | vs DET | 52 | L 1-8 | - | | 7,437 | Andy Replogle | Jim Slaton | Jim Slaton | Andy Replogle | | 260 | 237 | 23 |
| 1978-06-09 | vs TOR | 53 | W 3-2 | - | | 9,959 | Mike Caldwell | Jim Clancy | Mike Caldwell | Tom Murphy | | 263 | 239 | 24 |
| 1978-06-10 | vs TOR | 54 | W 5-0 | - | | 25,889 | Bill Travers | Jerry Garvin | Bill Travers | Jerry Garvin | | 268 | 239 | 29 |
| 1978-06-11 | vs TOR | 55 | W 2-1 | - | | 0 | Lary Sorensen | Tom Underwood | Lary Sorensen | Tom Underwood | | 270 | 240 | 30 |
| 1978-06-11 | vs TOR | 56 | W 5-4 | - | | 21,568 | Andy Replogle | Jesse Jefferson | Randy Stein | Tom Murphy | | 275 | 244 | 31 |
| 1978-06-12 | @ DET | 57 | W 7-4 | - | | 14,472 | Eduardo Rodriguez | Milt Wilcox | Bob McClure | Milt Wilcox | | 282 | 248 | 34 |
| 1978-06-13 | @ DET | 58 | W 7-2 | - | | 16,622 | Mike Caldwell | Jim Slaton | Mike Caldwell | Jim Slaton | | 289 | 250 | 39 |
| 1978-06-14 | @ TOR | 59 | W 7-5 | - | | 0 | Bill Travers | Don Kirkwood | Bill Castro | Tom Murphy | | 296 | 255 | 41 |
| 1978-06-14 | @ TOR | 60 | W 5-0 | - | | 28,346 | Jerry Augustine | Jerry Garvin | Jerry Augustine | Jerry Garvin | | 301 | 255 | 46 |
| 1978-06-16 | @ CLE | 61 | W 8-6 | - | | 9,175 | Lary Sorensen | Rick Wise | Bob McClure | Jim Kern | Bill Castro | 309 | 261 | 48 |
| 1978-06-17 | @ CLE | 62 | W 4-3 | - | | 16,923 | Andy Replogle | Don Hood | Bill Castro | Jim Kern | | 313 | 264 | 49 |
| 1978-06-18 | @ CLE | 63 | L 0-3 | - | | 0 | Mike Caldwell | Rick Waits | Rick Waits | Mike Caldwell | | 313 | 267 | 46 |
| 1978-06-18 | @ CLE | 64 | W 4-1 | - | | 20,140 | Jerry Augustine | Mike Paxton | Jerry Augustine | Mike Paxton | Bill Castro | 317 | 268 | 49 |
| 1978-06-20 | vs BAL | 65 | L 5-8 | - | | 22,640 | Bill Travers | Scott McGregor | Scott McGregor | Bill Travers | | 322 | 276 | 46 |
| 1978-06-21 | vs BAL | 66 | W 5-3 | - | | 21,732 | Lary Sorensen | Dennis Martinez | Lary Sorensen | Dennis Martinez | Bill Castro | 327 | 279 | 48 |
| 1978-06-22 | vs BAL | 67 | L 3-10 | - | | 26,586 | Moose Haas | Mike Flanagan | Mike Flanagan | Moose Haas | | 330 | 289 | 41 |
| 1978-06-23 | vs SEA | 68 | L 0-3 | - | | 8,268 | Mike Caldwell | Glenn Abbott | Glenn Abbott | Mike Caldwell | | 330 | 292 | 38 |
| 1978-06-24 | vs SEA | 69 | W 5-0 | - | | 20,820 | Jerry Augustine | Jim Colborn | Jerry Augustine | Jim Colborn | | 335 | 292 | 43 |
| 1978-06-25 | vs SEA | 70 | L 8-10 | - | | 24,526 | Bill Travers | Mike Parrott | Enrique Romo | Randy Stein | John Montague | 343 | 302 | 41 |
| 1978-06-26 | vs MIN | 71 | W 8-2 | - | | 7,988 | Lary Sorensen | Gary Serum | Lary Sorensen | Gary Serum | | 351 | 304 | 47 |
| 1978-06-27 | vs MIN | 72 | W 13-6 | - | | 16,137 | Moose Haas | Dave Goltz | Andy Replogle | Dave Goltz | | 364 | 310 | 54 |
| 1978-06-28 | vs NYA | 73 | W 5-0 | - | | 0 | Mike Caldwell | Dick Tidrow | Mike Caldwell | Dick Tidrow | | 369 | 310 | 59 |
| 1978-06-28 | vs NYA | 74 | W 7-2 | - | | 39,283 | Jerry Augustine | Larry McCall | Jerry Augustine | Larry McCall | | 376 | 312 | 64 |
| 1978-06-30 | @ SEA | 75 | W 13-3 | - | | 7,772 | Bill Travers | Mike Parrott | Bill Travers | Mike Parrott | Eduardo Rodriguez | 389 | 315 | 74 |
| 1978-07-01 | @ SEA | 76 | W 4-0 | - | | 14,836 | Lary Sorensen | Paul Mitchell | Lary Sorensen | Paul Mitchell | | 393 | 315 | 78 |
| 1978-07-02 | @ SEA | 77 | L 3-4 | - | | 9,904 | Mike Caldwell | Dick Pole | Shane Rawley | Bill Castro | | 396 | 319 | 77 |
| 1978-07-03 | @ MIN | 78 | L 2-7 | - | | 19,062 | Jerry Augustine | Roger Erickson | Roger Erickson | Jerry Augustine | | 398 | 326 | 72 |
| 1978-07-04 | @ MIN | 79 | L 2-7 | - | | 26,263 | Bill Travers | Gary Serum | Gary Serum | Bill Travers | | 400 | 333 | 67 |
| 1978-07-05 | @ MIN | 80 | L 1-3 | - | | 11,409 | Lary Sorensen | Dave Goltz | Dave Goltz | Lary Sorensen | | 401 | 336 | 65 |
| 1978-07-07 | vs NYA | 81 | W 6-0 | - | | 40,216 | Mike Caldwell | Ron Guidry | Mike Caldwell | Ron Guidry | | 407 | 336 | 71 |
| 1978-07-08 | vs NYA | 82 | W 6-5 | - | | 46,518 | Jerry Augustine | Dave Rajsich | Eduardo Rodriguez | Rich Gossage | Bob McClure | 413 | 341 | 72 |
| 1978-07-09 | vs NYA | 83 | W 8-4 | - | | 42,633 | Bill Travers | Don Gullett | Bill Travers | Don Gullett | Randy Stein | 421 | 345 | 76 |
| 1978-07-13 | vs KCA | 84 | W 13-2 | - | | 16,706 | Mike Caldwell | Paul Splittorff | Mike Caldwell | Paul Splittorff | | 434 | 347 | 87 |
| 1978-07-14 | vs KCA | 85 | L 2-9 | - | | 43,993 | Andy Replogle | Rich Gale | Rich Gale | Andy Replogle | | 436 | 356 | 80 |
| 1978-07-15 | vs CHA | 86 | W 3-1 | - | | 41,379 | Lary Sorensen | Ron Schueler | Lary Sorensen | Ron Schueler | | 439 | 357 | 82 |
| 1978-07-16 | vs CHA | 87 | W 10-1 | - | | 33,862 | Bill Travers | Steve Stone | Bill Travers | Steve Stone | | 449 | 358 | 91 |
| 1978-07-17 | vs CHA | 88 | W 6-1 | - | | 15,993 | Mike Caldwell | Francisco Barrios | Mike Caldwell | Francisco Barrios | | 455 | 359 | 96 |
| 1978-07-18 | vs CHA | 89 | W 7-2 | - | | 17,660 | Jerry Augustine | Wilbur Wood | Jerry Augustine | Wilbur Wood | | 462 | 361 | 101 |
| 1978-07-19 | vs BOS | 90 | L 2-8 | - | | 45,332 | Lary Sorensen | Mike Torrez | Mike Torrez | Lary Sorensen | | 464 | 369 | 95 |
| 1978-07-20 | vs BOS | 91 | W 8-6 | - | | 35,044 | Andy Replogle | Bill Lee | Eduardo Rodriguez | Bill Lee | Bob McClure | 472 | 375 | 97 |
| 1978-07-21 | @ TEX | 92 | W 4-3 | - | | 28,419 | Bill Travers | Doc Medich | Bill Travers | Doc Medich | Bob McClure | 476 | 378 | 98 |
| 1978-07-22 | @ TEX | 93 | W 2-1 | - | | 30,354 | Mike Caldwell | Jon Matlack | Mike Caldwell | Reggie Cleveland | | 478 | 379 | 99 |
| 1978-07-23 | @ TEX | 94 | W 17-8 | - | | 11,615 | Jerry Augustine | Steve Comer | Andy Replogle | Steve Comer | | 495 | 387 | 108 |
| 1978-07-24 | @ CHA | 95 | L 1-5 | - | | 11,091 | Lary Sorensen | Steve Stone | Steve Stone | Lary Sorensen | | 496 | 392 | 104 |
| 1978-07-25 | @ CHA | 96 | L 2-4 | - | | 28,057 | Eduardo Rodriguez | Francisco Barrios | Francisco Barrios | Eduardo Rodriguez | Mike Proly | 498 | 396 | 102 |
| 1978-07-26 | vs CAL | 97 | L 9-11 | - | | 21,584 | Bill Travers | Frank Tanana | Frank Tanana | Bill Travers | Dave LaRoche | 507 | 407 | 100 |
| 1978-07-27 | vs CAL | 98 | W 6-3 | - | | 18,847 | Mike Caldwell | Nolan Ryan | Mike Caldwell | Nolan Ryan | | 513 | 410 | 103 |
| 1978-07-28 | @ TOR | 99 | L 2-3 | - | | 17,060 | Jerry Augustine | Jesse Jefferson | Victor Cruz | Bill Castro | | 515 | 413 | 102 |
| 1978-07-29 | @ TOR | 100 | L 3-4 | - | | 25,037 | Lary Sorensen | Dave Lemanczyk | Dave Lemanczyk | Lary Sorensen | Victor Cruz | 518 | 417 | 101 |
| 1978-07-30 | @ TOR | 101 | W 10-5 | - | | 21,511 | Eduardo Rodriguez | Tom Underwood | Randy Stein | Tom Murphy | | 528 | 422 | 106 |
| 1978-07-31 | @ BAL | 102 | L 5-6 | - | | 10,514 | Bill Travers | Scott McGregor | Joe Kerrigan | Bill Castro | | 533 | 428 | 105 |
| 1978-08-02 | @ BAL | 103 | W 5-3 | - | | 10,663 | Mike Caldwell | Jim Palmer | Mike Caldwell | Jim Palmer | Lary Sorensen | 538 | 431 | 107 |
| 1978-08-03 | @ BAL | 104 | L 2-3 | - | | 9,654 | Jerry Augustine | Dennis Martinez | Dennis Martinez | Jerry Augustine | | 540 | 434 | 106 |
| 1978-08-04 | vs BOS | 105 | W 6-2 | - | | 52,562 | Lary Sorensen | Bill Lee | Lary Sorensen | Bill Lee | | 546 | 436 | 110 |
| 1978-08-05 | vs BOS | 106 | L 1-8 | - | | 52,968 | Eduardo Rodriguez | Dennis Eckersley | Dennis Eckersley | Eduardo Rodriguez | | 547 | 444 | 103 |
| 1978-08-06 | vs BOS | 107 | L 0-4 | - | | 48,444 | Bill Travers | Luis Tiant | Luis Tiant | Bill Travers | | 547 | 448 | 99 |
| 1978-08-08 | @ NYA | 108 | L 0-3 | - | | 22,549 | Mike Caldwell | Dick Tidrow | Dick Tidrow | Mike Caldwell | Rich Gossage | 547 | 451 | 96 |
| 1978-08-09 | @ NYA | 109 | L 7-8 | - | | 27,172 | Lary Sorensen | Ed Figueroa | Larry McCall | Bob McClure | | 554 | 459 | 95 |
| 1978-08-10 | @ NYA | 110 | L 0-9 | - | | 35,127 | Jerry Augustine | Ron Guidry | Ron Guidry | Jerry Augustine | | 554 | 468 | 86 |
| 1978-08-11 | @ BOS | 111 | W 10-5 | - | | 35,142 | Eduardo Rodriguez | Luis Tiant | Eduardo Rodriguez | Luis Tiant | | 564 | 473 | 91 |
| 1978-08-12 | @ BOS | 112 | L 1-3 | - | | 33,092 | Bill Travers | Jim Wright | Jim Wright | Bill Travers | | 565 | 476 | 89 |
| 1978-08-12 | @ BOS | 113 | L 4-11 | - | | 27,030 | Mike Caldwell | Bob Stanley | Bob Stanley | Mike Caldwell | | 569 | 487 | 82 |
| 1978-08-13 | @ BOS | 114 | L 3-4 | - | | 34,460 | Andy Replogle | Mike Torrez | Mike Torrez | Bill Castro | | 572 | 491 | 81 |
| 1978-08-14 | @ BOS | 115 | W 4-3 | - | | 33,766 | Lary Sorensen | Bill Lee | Lary Sorensen | Bill Lee | Bob McClure | 576 | 494 | 82 |
| 1978-08-15 | vs TOR | 116 | W 9-1 | - | | 0 | Jerry Augustine | Dave Lemanczyk | Jerry Augustine | Dave Lemanczyk | | 585 | 495 | 90 |
| 1978-08-16 | vs TOR | 117 | W 8-1 | - | | 0 | Mike Caldwell | Jesse Jefferson | Mike Caldwell | Jesse Jefferson | | 593 | 496 | 97 |
| 1978-08-16 | vs TOR | 118 | W 3-2 | - | | 16,920 | Eduardo Rodriguez | Balor Moore | Eduardo Rodriguez | Balor Moore | Bob McClure | 596 | 498 | 98 |
| 1978-08-17 | vs TOR | 119 | W 6-0 | - | | 18,829 | Bill Travers | Jim Clancy | Bill Travers | Jim Clancy | | 602 | 498 | 104 |
| 1978-08-18 | vs DET | 120 | W 2-0 | - | | 27,543 | Lary Sorensen | Dave Rozema | Lary Sorensen | Dave Rozema | | 604 | 498 | 106 |
| 1978-08-19 | vs DET | 121 | L 4-6 | - | | 35,104 | Jerry Augustine | Milt Wilcox | Milt Wilcox | Jerry Augustine | | 608 | 504 | 104 |
| 1978-08-20 | vs DET | 122 | W 2-1 | - | | 46,791 | Mike Caldwell | Kip Young | Mike Caldwell | Kip Young | | 610 | 505 | 105 |
| 1978-08-22 | vs CLE | 123 | W 3-2 | - | | 0 | Bill Travers | David Clyde | Bill Castro | Jim Kern | | 613 | 507 | 106 |
| 1978-08-22 | vs CLE | 124 | W 5-4 | - | | 23,918 | Eduardo Rodriguez | Paul Reuschel | Willie Mueller | Jim Kern | | 618 | 511 | 107 |
| 1978-08-23 | vs CLE | 125 | W 9-4 | - | | 20,157 | Lary Sorensen | Rick Wise | Andy Replogle | Sid Monge | | 627 | 515 | 112 |
| 1978-08-24 | vs CLE | 126 | L 8-9 | - | | 16,362 | Jerry Augustine | Mike Paxton | Dan Spillner | Bob McClure | Sid Monge | 635 | 524 | 111 |
| 1978-08-25 | @ DET | 127 | L 3-6 | - | | 32,010 | Mike Caldwell | Kip Young | Kip Young | Mike Caldwell | John Hiller | 638 | 530 | 108 |
| 1978-08-26 | @ DET | 128 | W 9-5 | - | | 32,103 | Bill Travers | Jack Billingham | Bill Travers | Jack Billingham | Bob McClure | 647 | 535 | 112 |
| 1978-08-27 | @ DET | 129 | L 2-4 | - | | 43,478 | Lary Sorensen | Jim Slaton | Jim Slaton | Lary Sorensen | John Hiller | 649 | 539 | 110 |
| 1978-08-28 | @ DET | 130 | W 10-1 | - | | 23,037 | Jerry Augustine | Dave Rozema | Jerry Augustine | Dave Rozema | | 659 | 540 | 119 |
| 1978-08-29 | @ CLE | 131 | W 6-0 | - | | 5,498 | Andy Replogle | Rick Wise | Andy Replogle | Rick Wise | | 665 | 540 | 125 |
| 1978-08-31 | @ CLE | 132 | W 1-0 | - | | 0 | Mike Caldwell | Mike Paxton | Mike Caldwell | Mike Paxton | | 666 | 540 | 126 |
| 1978-08-31 | @ CLE | 133 | L 6-12 | - | | 5,328 | Bill Travers | Rick Waits | Rick Waits | Bill Travers | | 672 | 552 | 120 |
| 1978-09-01 | vs TEX | 134 | L 4-5 | - | | 13,648 | Lary Sorensen | Fergie Jenkins | Fergie Jenkins | Lary Sorensen | Reggie Cleveland | 676 | 557 | 119 |
| 1978-09-02 | vs TEX | 135 | W 10-6 | - | | 17,795 | Jerry Augustine | Doc Medich | Bill Castro | Len Barker | | 686 | 563 | 123 |
| 1978-09-03 | vs TEX | 136 | W 4-3 | - | | 14,014 | Andy Replogle | Jon Matlack | Ed Farmer | Jon Matlack | | 690 | 566 | 124 |
| 1978-09-04 | vs SEA | 137 | L 3-4 | - | | 0 | Mike Caldwell | Glenn Abbott | Glenn Abbott | Mike Caldwell | | 693 | 570 | 123 |
| 1978-09-04 | vs SEA | 138 | W 5-0 | - | | 19,408 | Bill Travers | Byron McLaughlin | Bill Travers | Byron McLaughlin | | 698 | 570 | 128 |
| 1978-09-06 | @ TOR | 139 | W 7-0 | - | | 21,390 | Lary Sorensen | Jesse Jefferson | Lary Sorensen | Jesse Jefferson | | 705 | 570 | 135 |
| 1978-09-07 | @ TOR | 140 | L 4-5 | - | | 12,092 | Jerry Augustine | Jim Clancy | Victor Cruz | Bob McClure | | 709 | 575 | 134 |
| 1978-09-08 | @ MIN | 141 | W 3-0 | - | | 9,262 | Andy Replogle | Gary Serum | Andy Replogle | Gary Serum | | 712 | 575 | 137 |
| 1978-09-09 | @ MIN | 142 | W 3-0 | - | | 10,639 | Mike Caldwell | Roger Erickson | Mike Caldwell | Roger Erickson | | 715 | 575 | 140 |
| 1978-09-10 | @ MIN | 143 | L 1-3 | - | | 10,512 | Bill Travers | Dave Goltz | Dave Goltz | Bill Travers | | 716 | 578 | 138 |
| 1978-09-11 | @ SEA | 144 | W 5-3 | - | | 5,246 | Lary Sorensen | Byron McLaughlin | Lary Sorensen | Byron McLaughlin | Bill Castro | 721 | 581 | 140 |
| 1978-09-12 | @ SEA | 145 | L 5-6 | - | | 5,577 | Mark Bomback | Paul Mitchell | Jim Todd | Bob McClure | | 726 | 587 | 139 |
| 1978-09-13 | vs BAL | 146 | W 7-5 | - | | 8,863 | Andy Replogle | Mike Flanagan | Andy Replogle | Mike Flanagan | Ed Farmer | 733 | 592 | 141 |
| 1978-09-14 | vs BAL | 147 | W 4-3 | - | | 12,587 | Mike Caldwell | Scott McGregor | Mike Caldwell | Scott McGregor | | 737 | 595 | 142 |
| 1978-09-15 | vs MIN | 148 | L 3-10 | - | | 12,496 | Bill Travers | Roger Erickson | Roger Erickson | Bill Travers | | 740 | 605 | 135 |
| 1978-09-16 | vs MIN | 149 | L 2-5 | - | | 37,809 | Lary Sorensen | Dave Goltz | Dave Goltz | Lary Sorensen | Mike Marshall | 742 | 610 | 132 |
| 1978-09-17 | vs MIN | 150 | L 3-4 | - | | 11,007 | Andy Replogle | Gary Serum | Gary Serum | Andy Replogle | Mike Marshall | 745 | 614 | 131 |
| 1978-09-18 | @ NYA | 151 | L 3-4 | - | | 20,557 | Bill Travers | Ed Figueroa | Ed Figueroa | Bill Travers | | 748 | 618 | 130 |
| 1978-09-19 | @ NYA | 152 | W 2-0 | - | | 26,682 | Mike Caldwell | Dick Tidrow | Mike Caldwell | Dick Tidrow | | 750 | 618 | 132 |
| 1978-09-20 | @ KCA | 153 | W 5-4 | - | | 15,917 | Lary Sorensen | Rich Gale | Jerry Augustine | Bill Paschall | | 755 | 622 | 133 |
| 1978-09-21 | @ KCA | 154 | L 4-8 | - | | 17,799 | Andy Replogle | Dennis Leonard | Dennis Leonard | Andy Replogle | | 759 | 630 | 129 |
| 1978-09-22 | vs OAK | 155 | W 3-0 | - | | 9,675 | Eduardo Rodriguez | Matt Keough | Eduardo Rodriguez | Matt Keough | Bill Castro | 762 | 630 | 132 |
| 1978-09-23 | vs OAK | 156 | W 13-4 | - | | 14,450 | Bill Travers | Mike Norris | Bill Travers | Mike Norris | | 775 | 634 | 141 |
| 1978-09-24 | vs OAK | 157 | W 5-2 | - | | 16,535 | Mike Caldwell | Rick Langford | Mike Caldwell | Rick Langford | | 780 | 636 | 144 |
| 1978-09-26 | @ CAL | 158 | L 3-4 | - | | 12,646 | Lary Sorensen | Don Aase | Dave LaRoche | Lary Sorensen | | 783 | 640 | 143 |
| 1978-09-27 | @ CAL | 159 | L 1-4 | - | | 12,302 | Andy Replogle | Dave Frost | Dave Frost | Andy Replogle | Dave LaRoche | 784 | 644 | 140 |
| 1978-09-29 | @ OAK | 160 | W 3-1 | - | | 1,992 | Bill Travers | Matt Keough | Bill Travers | Matt Keough | | 787 | 645 | 142 |
| 1978-09-30 | @ OAK | 161 | W 8-5 | - | | 2,143 | Mike Caldwell | John Henry Johnson | Mike Caldwell | John Henry Johnson | Bill Castro | 795 | 650 | 145 |
| 1978-10-01 | @ OAK | 162 | W 9-0 | - | | 2,742 | Lary Sorensen | Alan Wirth | Lary Sorensen | Alan Wirth | Moose Haas | 804 | 650 | 154 |