| 1978-04-07 | @ ATL | 1 | W 13-4 | 1-0 | 2 | 42,866 | Don Sutton | Phil Niekro | Don Sutton | Phil Niekro | | 13 | 4 | 9 |
| 1978-04-08 | @ ATL | 2 | W 6-2 | 2-0 | 2 | 11,265 | Tommy John | Dick Ruthven | Tommy John | Dick Ruthven | Terry Forster | 19 | 6 | 13 |
| 1978-04-09 | @ ATL | 3 | W 7-4 | 3-0 | 2 | 11,473 | Rick Rhoden | Tommy Boggs | Rick Rhoden | Tommy Boggs | Bobby Castillo | 26 | 10 | 16 |
| 1978-04-10 | @ HOU | 4 | W 5-2 | 4-0 | 2 | 22,882 | Doug Rau | Floyd Bannister | Doug Rau | Floyd Bannister | Terry Forster | 31 | 12 | 19 |
| 1978-04-11 | @ HOU | 5 | L 0-1 | 4-1 | 2 | 11,049 | Burt Hooton | J.R. Richard | J.R. Richard | Burt Hooton | | 31 | 13 | 18 |
| 1978-04-12 | @ HOU | 6 | L 10-11 | 4-2 | 2 | 11,824 | Don Sutton | Joe Niekro | Joe Sambito | Bobby Castillo | | 41 | 24 | 17 |
| 1978-04-14 | vs ATL | 7 | W 5-1 | 5-2 | 2 | 38,397 | Tommy John | Dick Ruthven | Tommy John | Dick Ruthven | | 46 | 25 | 21 |
| 1978-04-16 | vs ATL | 8 | W 8-0 | 6-2 | 1 | 37,161 | Rick Rhoden | Phil Niekro | Rick Rhoden | Phil Niekro | | 54 | 25 | 29 |
| 1978-04-17 | vs CIN | 9 | L 2-8 | 6-3 | 2 | 40,527 | Burt Hooton | Bill Bonham | Bill Bonham | Burt Hooton | | 56 | 33 | 23 |
| 1978-04-18 | vs CIN | 10 | L 3-11 | 6-4 | 2 | 50,374 | Don Sutton | Fred Norman | Fred Norman | Don Sutton | Dale Murray | 59 | 44 | 15 |
| 1978-04-19 | vs CIN | 11 | W 5-4 | 7-4 | 2 | 49,333 | Tommy John | Tom Hume | Tommy John | Tom Hume | | 64 | 48 | 16 |
| 1978-04-20 | vs HOU | 12 | W 5-1 | 8-4 | 2 | 24,049 | Doug Rau | Mark Lemongello | Doug Rau | Mark Lemongello | | 69 | 49 | 20 |
| 1978-04-21 | vs HOU | 13 | L 6-8 | 8-5 | 2 | 44,867 | Rick Rhoden | J.R. Richard | Ken Forsch | Bobby Castillo | | 75 | 57 | 18 |
| 1978-04-22 | vs HOU | 14 | W 5-1 | 9-5 | 2 | 52,346 | Burt Hooton | Floyd Bannister | Burt Hooton | Floyd Bannister | | 80 | 58 | 22 |
| 1978-04-23 | vs HOU | 15 | W 7-3 | 10-5 | 2 | 51,500 | Don Sutton | Joe Niekro | Don Sutton | Joe Niekro | | 87 | 61 | 26 |
| 1978-04-25 | @ CIN | 16 | W 4-2 | 11-5 | 1 | 27,361 | Tommy John | Tom Hume | Tommy John | Tom Hume | | 91 | 63 | 28 |
| 1978-04-26 | @ CIN | 17 | W 14-4 | 12-5 | 1 | 32,872 | Doug Rau | Tom Seaver | Doug Rau | Tom Seaver | | 105 | 67 | 38 |
| 1978-04-28 | @ SLN | 18 | W 7-1 | 13-5 | 1 | 23,823 | Rick Rhoden | Bob Forsch | Rick Rhoden | Bob Forsch | | 112 | 68 | 44 |
| 1978-04-29 | @ SLN | 19 | L 0-1 | 13-6 | 1 | 20,596 | Burt Hooton | Eric Rasmussen | Eric Rasmussen | Burt Hooton | | 112 | 69 | 43 |
| 1978-04-30 | @ SLN | 20 | L 0-4 | 13-7 | 1 | 21,677 | Don Sutton | John Urrea | John Urrea | Don Sutton | Pete Vuckovich | 112 | 73 | 39 |
| 1978-05-02 | @ CHN | 21 | L 4-5 | 13-8 | 1 | 6,990 | Tommy John | Rick Reuschel | Bruce Sutter | Mike Garman | | 116 | 78 | 38 |
| 1978-05-03 | @ CHN | 22 | W 9-5 | 14-8 | 1 | 9,252 | Doug Rau | Ray Burris | Doug Rau | Ray Burris | Terry Forster | 125 | 83 | 42 |
| 1978-05-04 | @ CHN | 23 | W 4-1 | 15-8 | 1 | 4,030 | Rick Rhoden | Woodie Fryman | Rick Rhoden | Woodie Fryman | | 129 | 84 | 45 |
| 1978-05-05 | @ PIT | 24 | W 7-2 | 16-8 | 1 | 7,580 | Burt Hooton | Bert Blyleven | Burt Hooton | Bert Blyleven | | 136 | 86 | 50 |
| 1978-05-06 | @ PIT | 25 | L 2-3 | 16-9 | 1 | 8,919 | Don Sutton | John Candelaria | John Candelaria | Don Sutton | Grant Jackson | 138 | 89 | 49 |
| 1978-05-07 | @ PIT | 26 | L 4-6 | 16-10 | 1 | 18,208 | Tommy John | Jim Rooker | Jim Rooker | Tommy John | Kent Tekulve | 142 | 95 | 47 |
| 1978-05-09 | vs SLN | 27 | W 3-1 | 17-10 | 1 | 33,262 | Doug Rau | Eric Rasmussen | Doug Rau | Eric Rasmussen | Terry Forster | 145 | 96 | 49 |
| 1978-05-10 | vs SLN | 28 | L 5-6 | 17-11 | 1 | 34,851 | Rick Rhoden | John Denny | Mark Littell | Rick Rhoden | | 150 | 102 | 48 |
| 1978-05-11 | vs SLN | 29 | L 0-2 | 17-12 | 1 | 30,007 | Burt Hooton | Bob Forsch | Bob Forsch | Burt Hooton | | 150 | 104 | 46 |
| 1978-05-12 | vs CHN | 30 | L 7-9 | 17-13 | 3 | 52,562 | Don Sutton | Ray Burris | Donnie Moore | Don Sutton | Bruce Sutter | 157 | 113 | 44 |
| 1978-05-13 | vs CHN | 31 | W 5-2 | 18-13 | 3 | 47,970 | Tommy John | Woodie Fryman | Tommy John | Woodie Fryman | Terry Forster | 162 | 115 | 47 |
| 1978-05-14 | vs CHN | 32 | L 7-10 | 18-14 | 3 | 31,698 | Doug Rau | Dennis Lamp | Paul Reuschel | Rick Rhoden | | 169 | 125 | 44 |
| 1978-05-15 | vs PIT | 33 | W 7-6 | 19-14 | 3 | 35,297 | Burt Hooton | Bert Blyleven | Charlie Hough | Bert Blyleven | | 176 | 131 | 45 |
| 1978-05-16 | vs PIT | 34 | W 3-2 | 20-14 | 3 | 32,243 | Don Sutton | John Candelaria | Don Sutton | John Candelaria | Terry Forster | 179 | 133 | 46 |
| 1978-05-17 | vs PIT | 35 | W 10-1 | 21-14 | 2 | 33,097 | Tommy John | Jim Rooker | Tommy John | Jim Rooker | | 189 | 134 | 55 |
| 1978-05-19 | vs SFN | 36 | L 7-10 | 21-15 | 3 | 52,389 | Rick Rhoden | John Montefusco | John Montefusco | Bobby Castillo | Gary Lavelle | 196 | 144 | 52 |
| 1978-05-20 | vs SFN | 37 | W 3-2 | 22-15 | 3 | 51,370 | Doug Rau | Ed Halicki | Terry Forster | Gary Lavelle | | 199 | 146 | 53 |
| 1978-05-21 | vs SFN | 38 | W 4-1 | 23-15 | 2 | 49,354 | Burt Hooton | Bob Knepper | Burt Hooton | Bob Knepper | Terry Forster | 203 | 147 | 56 |
| 1978-05-22 | @ SDN | 39 | W 8-1 | 24-15 | 2 | 21,957 | Don Sutton | Bob Owchinko | Don Sutton | Bob Owchinko | | 211 | 148 | 63 |
| 1978-05-23 | @ SDN | 40 | L 2-3 | 24-16 | 2 | 27,512 | Tommy John | Randy Jones | Rollie Fingers | Tommy John | | 213 | 151 | 62 |
| 1978-05-24 | @ SDN | 41 | L 3-9 | 24-17 | 3 | 27,100 | Rick Rhoden | Gaylord Perry | Gaylord Perry | Rick Rhoden | John D'Acquisto | 216 | 160 | 56 |
| 1978-05-26 | @ SFN | 42 | L 1-6 | 24-18 | 3 | 43,646 | Doug Rau | Bob Knepper | Bob Knepper | Doug Rau | | 217 | 166 | 51 |
| 1978-05-27 | @ SFN | 43 | W 3-1 | 25-18 | 3 | 45,865 | Burt Hooton | Vida Blue | Burt Hooton | Vida Blue | Terry Forster | 220 | 167 | 53 |
| 1978-05-28 | @ SFN | 44 | L 5-6 | 25-19 | 3 | 56,103 | Don Sutton | John Montefusco | Randy Moffitt | Don Sutton | | 225 | 173 | 52 |
| 1978-05-29 | vs SDN | 45 | W 9-6 | 26-19 | 3 | 51,781 | Tommy John | Gaylord Perry | Tommy John | Gaylord Perry | | 234 | 179 | 55 |
| 1978-05-30 | vs SDN | 46 | W 10-2 | 27-19 | 3 | 31,636 | Rick Rhoden | Eric Rasmussen | Rick Rhoden | Eric Rasmussen | | 244 | 181 | 63 |
| 1978-05-31 | vs SDN | 47 | L 1-3 | 27-20 | 3 | 28,050 | Doug Rau | Bob Shirley | Bob Shirley | Doug Rau | Rollie Fingers | 245 | 184 | 61 |
| 1978-06-02 | @ PHI | 48 | L 2-4 | 27-21 | 3 | 42,347 | Burt Hooton | Jim Lonborg | Jim Lonborg | Burt Hooton | Gene Garber | 247 | 188 | 59 |
| 1978-06-03 | @ PHI | 49 | L 1-5 | 27-22 | 3 | 31,442 | Don Sutton | Larry Christenson | Tug McGraw | Terry Forster | | 248 | 193 | 55 |
| 1978-06-04 | @ PHI | 50 | L 4-9 | 27-23 | 3 | 42,066 | Tommy John | Jim Kaat | Jim Kaat | Tommy John | | 252 | 202 | 50 |
| 1978-06-05 | @ NYN | 51 | L 8-9 | 27-24 | 3 | 14,435 | Rick Rhoden | Mike Bruhert | Skip Lockwood | Terry Forster | | 260 | 211 | 49 |
| 1978-06-06 | @ NYN | 52 | W 8-2 | 28-24 | 3 | 17,377 | Doug Rau | Nino Espinosa | Doug Rau | Nino Espinosa | | 268 | 213 | 55 |
| 1978-06-07 | @ NYN | 53 | L 2-3 | 28-25 | 3 | 7,453 | Burt Hooton | Pat Zachry | Pat Zachry | Charlie Hough | | 270 | 216 | 54 |
| 1978-06-08 | @ MON | 54 | L 1-4 | 28-26 | 3 | 20,004 | Don Sutton | Steve Rogers | Steve Rogers | Don Sutton | | 271 | 220 | 51 |
| 1978-06-09 | @ MON | 55 | L 9-10 | 28-27 | 3 | 21,719 | Tommy John | Rudy May | Dan Schatzeder | Tommy John | Darold Knowles | 280 | 230 | 50 |
| 1978-06-10 | @ MON | 56 | W 5-4 | 29-27 | 3 | 39,104 | Rick Rhoden | Wayne Twitchell | Lance Rautzhan | Bill Atkinson | Terry Forster | 285 | 234 | 51 |
| 1978-06-11 | @ MON | 57 | W 11-4 | 30-27 | 3 | 48,389 | Doug Rau | Ross Grimsley | Charlie Hough | Ross Grimsley | | 296 | 238 | 58 |
| 1978-06-12 | vs PHI | 58 | W 6-5 | 31-27 | 3 | 26,604 | Burt Hooton | Jim Lonborg | Burt Hooton | Jim Lonborg | Lance Rautzhan | 302 | 243 | 59 |
| 1978-06-13 | vs PHI | 59 | W 5-3 | 32-27 | 3 | 41,257 | Don Sutton | Randy Lerch | Don Sutton | Randy Lerch | | 307 | 246 | 61 |
| 1978-06-14 | vs NYN | 60 | W 5-3 | 33-27 | 3 | 31,185 | Tommy John | Jerry Koosman | Tommy John | Jerry Koosman | Charlie Hough | 312 | 249 | 63 |
| 1978-06-15 | vs NYN | 61 | W 3-0 | 34-27 | 3 | 31,308 | Rick Rhoden | Nino Espinosa | Rick Rhoden | Nino Espinosa | Charlie Hough | 315 | 249 | 66 |
| 1978-06-16 | vs MON | 62 | W 2-1 | 35-27 | 3 | 45,538 | Doug Rau | Steve Rogers | Doug Rau | Steve Rogers | | 317 | 250 | 67 |
| 1978-06-17 | vs MON | 63 | L 3-6 | 35-28 | 3 | 51,247 | Burt Hooton | Rudy May | Dan Schatzeder | Burt Hooton | Hal Dues | 320 | 256 | 64 |
| 1978-06-18 | vs MON | 64 | W 5-0 | 36-28 | 3 | 41,769 | Don Sutton | Wayne Twitchell | Don Sutton | Wayne Twitchell | | 325 | 256 | 69 |
| 1978-06-20 | vs HOU | 65 | L 3-5 | 36-29 | 3 | 41,991 | Tommy John | J.R. Richard | J.R. Richard | Tommy John | Bo McLaughlin | 328 | 261 | 67 |
| 1978-06-21 | vs HOU | 66 | W 5-4 | 37-29 | 3 | 34,975 | Rick Rhoden | Mark Lemongello | Bob Welch | Joe Sambito | | 333 | 265 | 68 |
| 1978-06-22 | vs HOU | 67 | L 3-4 | 37-30 | 3 | 31,246 | Doug Rau | Joe Niekro | Joe Niekro | Doug Rau | | 336 | 269 | 67 |
| 1978-06-23 | vs CIN | 68 | W 1-0 | 38-30 | 3 | 51,068 | Burt Hooton | Fred Norman | Burt Hooton | Fred Norman | | 337 | 269 | 68 |
| 1978-06-24 | vs CIN | 69 | W 4-3 | 39-30 | 3 | 46,274 | Don Sutton | Tom Hume | Don Sutton | Tom Hume | Bob Welch | 341 | 272 | 69 |
| 1978-06-25 | vs CIN | 70 | L 4-5 | 39-31 | 3 | 50,356 | Tommy John | Paul Moskau | Pedro Borbon | Tommy John | Doug Bair | 345 | 277 | 68 |
| 1978-06-26 | @ ATL | 71 | L 2-5 | 39-32 | 3 | 8,991 | Rick Rhoden | Adrian Devine | Adrian Devine | Rick Rhoden | Gene Garber | 347 | 282 | 65 |
| 1978-06-27 | @ ATL | 72 | W 3-0 | 40-32 | 3 | 26,245 | Doug Rau | Rick Camp | Doug Rau | Dave Campbell | | 350 | 282 | 68 |
| 1978-06-28 | @ ATL | 73 | W 3-2 | 41-32 | 3 | 7,624 | Burt Hooton | Phil Niekro | Burt Hooton | Phil Niekro | Terry Forster | 353 | 284 | 69 |
| 1978-06-29 | @ ATL | 74 | W 7-3 | 42-32 | 3 | 7,408 | Don Sutton | Preston Hanna | Don Sutton | Preston Hanna | | 360 | 287 | 73 |
| 1978-06-30 | @ CIN | 75 | W 5-3 | 44-32 | 2 | 0 | Tommy John | Paul Moskau | Tommy John | Doug Bair | Lance Rautzhan | 365 | 290 | 75 |
| 1978-06-30 | @ CIN | 76 | W 5-2 | 44-32 | 2 | 50,370 | Bob Welch | Manny Sarmiento | Bob Welch | Manny Sarmiento | Charlie Hough | 370 | 292 | 78 |
| 1978-07-01 | @ CIN | 77 | W 2-0 | 45-32 | 2 | 48,044 | Rick Rhoden | Tom Seaver | Rick Rhoden | Tom Seaver | | 372 | 292 | 80 |
| 1978-07-02 | @ CIN | 78 | L 6-7 | 45-33 | 2 | 46,067 | Doug Rau | Bill Bonham | Doug Bair | Doug Rau | | 378 | 299 | 79 |
| 1978-07-03 | vs ATL | 79 | L 2-4 | 45-34 | 3 | 52,190 | Burt Hooton | Rick Camp | Rick Camp | Burt Hooton | Gene Garber | 380 | 303 | 77 |
| 1978-07-04 | vs ATL | 80 | W 4-1 | 46-34 | 2 | 49,691 | Don Sutton | Preston Hanna | Don Sutton | Preston Hanna | Bob Welch | 384 | 304 | 80 |
| 1978-07-05 | vs ATL | 81 | L 8-9 | 46-35 | 3 | 39,036 | Tommy John | Adrian Devine | Dave Campbell | Charlie Hough | Gene Garber | 392 | 313 | 79 |
| 1978-07-06 | vs ATL | 82 | W 5-1 | 47-35 | 3 | 18,355 | Rick Rhoden | Phil Niekro | Charlie Hough | Craig Skok | | 397 | 314 | 83 |
| 1978-07-07 | @ HOU | 83 | W 7-4 | 48-35 | 2 | 20,707 | Doug Rau | Mark Lemongello | Doug Rau | Mark Lemongello | Charlie Hough | 404 | 318 | 86 |
| 1978-07-08 | @ HOU | 84 | W 7-1 | 50-35 | 2 | 0 | Burt Hooton | Floyd Bannister | Burt Hooton | Floyd Bannister | | 411 | 319 | 92 |
| 1978-07-08 | @ HOU | 85 | W 7-5 | 50-35 | 2 | 37,073 | Bob Welch | Tom Dixon | Tommy John | Tom Dixon | | 418 | 324 | 94 |
| 1978-07-09 | @ HOU | 86 | L 1-5 | 50-36 | 2 | 30,285 | Don Sutton | J.R. Richard | J.R. Richard | Don Sutton | | 419 | 329 | 90 |
| 1978-07-13 | @ SLN | 87 | L 1-6 | 50-37 | 2 | 16,819 | Tommy John | John Denny | John Denny | Tommy John | | 420 | 335 | 85 |
| 1978-07-14 | @ SLN | 88 | L 1-4 | 50-38 | 3 | 23,694 | Don Sutton | Pete Vuckovich | Pete Vuckovich | Don Sutton | | 421 | 339 | 82 |
| 1978-07-15 | @ SLN | 89 | W 2-1 | 51-38 | 3 | 33,903 | Doug Rau | Bob Forsch | Doug Rau | Bob Forsch | Terry Forster | 423 | 340 | 83 |
| 1978-07-16 | @ CHN | 90 | L 2-3 | 52-39 | 3 | 0 | Rick Rhoden | Mike Krukow | Mike Krukow | Rick Rhoden | Bruce Sutter | 425 | 343 | 82 |
| 1978-07-16 | @ CHN | 91 | W 5-3 | 52-39 | 3 | 41,677 | Burt Hooton | Ray Burris | Burt Hooton | Ray Burris | Lance Rautzhan | 430 | 346 | 84 |
| 1978-07-17 | @ CHN | 92 | W 4-3 | 53-39 | 3 | 26,821 | Tommy John | Rick Reuschel | Terry Forster | Rick Reuschel | Bob Welch | 434 | 349 | 85 |
| 1978-07-18 | @ PIT | 93 | W 7-2 | 54-39 | 2 | 15,125 | Don Sutton | Don Robinson | Don Sutton | Don Robinson | | 441 | 351 | 90 |
| 1978-07-19 | @ PIT | 94 | L 3-6 | 54-40 | 3 | 15,527 | Doug Rau | Jim Rooker | Jim Rooker | Doug Rau | Kent Tekulve | 444 | 357 | 87 |
| 1978-07-20 | @ PIT | 95 | L 6-7 | 54-41 | 3 | 13,823 | Rick Rhoden | Bert Blyleven | Bruce Kison | Terry Forster | | 450 | 364 | 86 |
| 1978-07-21 | vs SLN | 96 | W 7-5 | 55-41 | 3 | 51,911 | Burt Hooton | Silvio Martinez | Burt Hooton | Silvio Martinez | Terry Forster | 457 | 369 | 88 |
| 1978-07-22 | vs SLN | 97 | W 4-3 | 56-41 | 3 | 42,165 | Tommy John | John Denny | Tommy John | John Denny | Terry Forster | 461 | 372 | 89 |
| 1978-07-23 | vs SLN | 98 | L 0-2 | 56-42 | 3 | 48,184 | Don Sutton | Pete Vuckovich | Pete Vuckovich | Don Sutton | | 461 | 374 | 87 |
| 1978-07-24 | vs CHN | 99 | W 3-2 | 57-42 | 3 | 46,822 | Bob Welch | Mike Krukow | Terry Forster | Donnie Moore | | 464 | 376 | 88 |
| 1978-07-25 | vs CHN | 100 | W 3-1 | 58-42 | 3 | 38,465 | Rick Rhoden | Rick Reuschel | Rick Rhoden | Rick Reuschel | Tommy John | 467 | 377 | 90 |
| 1978-07-26 | vs CHN | 101 | W 8-2 | 59-42 | 2 | 47,329 | Burt Hooton | Dave Roberts | Burt Hooton | Dave Roberts | | 475 | 379 | 96 |
| 1978-07-28 | vs PIT | 102 | W 7-3 | 60-42 | 2 | 43,600 | Tommy John | John Candelaria | Tommy John | John Candelaria | Terry Forster | 482 | 382 | 100 |
| 1978-07-29 | vs PIT | 103 | W 2-1 | 61-42 | 1 | 46,139 | Don Sutton | Don Robinson | Don Sutton | Don Robinson | | 484 | 383 | 101 |
| 1978-07-30 | vs PIT | 104 | L 3-5 | 61-43 | 3 | 48,587 | Doug Rau | Jim Rooker | Jim Rooker | Doug Rau | Kent Tekulve | 487 | 388 | 99 |
| 1978-07-31 | @ SDN | 105 | L 3-4 | 61-44 | 3 | 28,592 | Rick Rhoden | Eric Rasmussen | Eric Rasmussen | Rick Rhoden | Rollie Fingers | 490 | 392 | 98 |
| 1978-08-01 | @ SDN | 106 | L 0-1 | 61-45 | 3 | 40,846 | Burt Hooton | Randy Jones | Randy Jones | Burt Hooton | | 490 | 393 | 97 |
| 1978-08-02 | @ SDN | 107 | L 1-2 | 61-46 | 3 | 46,751 | Tommy John | Bob Owchinko | Bob Owchinko | Tommy John | Rollie Fingers | 491 | 395 | 96 |
| 1978-08-03 | @ SFN | 108 | L 4-5 | 61-47 | 3 | 42,084 | Don Sutton | Jim Barr | Randy Moffitt | Terry Forster | | 495 | 400 | 95 |
| 1978-08-04 | @ SFN | 109 | L 1-2 | 61-48 | 3 | 47,944 | Doug Rau | Vida Blue | Vida Blue | Doug Rau | Randy Moffitt | 496 | 402 | 94 |
| 1978-08-05 | @ SFN | 110 | W 2-0 | 62-48 | 3 | 49,203 | Bob Welch | Ed Halicki | Bob Welch | Ed Halicki | | 498 | 402 | 96 |
| 1978-08-06 | @ SFN | 111 | W 5-1 | 63-48 | 3 | 54,723 | Burt Hooton | Bob Knepper | Burt Hooton | Bob Knepper | | 503 | 403 | 100 |
| 1978-08-07 | vs SDN | 112 | W 3-1 | 64-48 | 3 | 37,161 | Tommy John | Bob Owchinko | Tommy John | Bob Owchinko | | 506 | 404 | 102 |
| 1978-08-08 | vs SDN | 113 | W 3-2 | 65-48 | 3 | 43,515 | Don Sutton | Gaylord Perry | Don Sutton | Gaylord Perry | | 509 | 406 | 103 |
| 1978-08-09 | vs SDN | 114 | W 3-0 | 66-48 | 3 | 41,597 | Doug Rau | Eric Rasmussen | Doug Rau | Eric Rasmussen | | 512 | 406 | 106 |
| 1978-08-10 | vs SFN | 115 | W 12-2 | 67-48 | 1 | 50,990 | Bob Welch | Vida Blue | Bob Welch | Vida Blue | | 524 | 408 | 116 |
| 1978-08-11 | vs SFN | 116 | W 4-3 | 68-48 | 1 | 52,869 | Burt Hooton | Ed Halicki | Terry Forster | Gary Lavelle | | 528 | 411 | 117 |
| 1978-08-12 | vs SFN | 117 | L 2-3 | 68-49 | 1 | 52,294 | Tommy John | Bob Knepper | Bob Knepper | Tommy John | | 530 | 414 | 116 |
| 1978-08-13 | vs SFN | 118 | L 6-7 | 68-50 | 2 | 51,417 | Don Sutton | John Montefusco | John Curtis | Charlie Hough | Ed Halicki | 536 | 421 | 115 |
| 1978-08-15 | @ PHI | 119 | W 5-4 | 69-50 | 1 | 38,386 | Doug Rau | Dick Ruthven | Doug Rau | Dick Ruthven | Lance Rautzhan | 541 | 425 | 116 |
| 1978-08-16 | @ PHI | 120 | W 5-2 | 70-50 | 1 | 37,660 | Bob Welch | Jim Kaat | Bob Welch | Jim Kaat | | 546 | 427 | 119 |
| 1978-08-17 | @ PHI | 121 | W 5-2 | 71-50 | 1 | 36,325 | Burt Hooton | Randy Lerch | Burt Hooton | Tug McGraw | Terry Forster | 551 | 429 | 122 |
| 1978-08-18 | @ NYN | 122 | W 7-3 | 72-50 | 1 | 26,660 | Tommy John | Nino Espinosa | Tommy John | Nino Espinosa | Charlie Hough | 558 | 432 | 126 |
| 1978-08-19 | @ NYN | 123 | L 4-8 | 72-51 | 1 | 22,963 | Don Sutton | Mike Bruhert | Dale Murray | Don Sutton | Skip Lockwood | 562 | 440 | 122 |
| 1978-08-20 | @ NYN | 124 | W 5-4 | 73-51 | 1 | 34,745 | Doug Rau | Craig Swan | Charlie Hough | Skip Lockwood | Terry Forster | 567 | 444 | 123 |
| 1978-08-21 | @ MON | 125 | L 2-4 | 73-52 | 1 | 25,461 | Bob Welch | Ross Grimsley | Ross Grimsley | Bob Welch | | 569 | 448 | 121 |
| 1978-08-23 | @ MON | 126 | W 4-2 | 74-52 | 1 | 31,696 | Burt Hooton | Steve Rogers | Burt Hooton | Steve Rogers | Charlie Hough | 573 | 450 | 123 |
| 1978-08-24 | vs PHI | 127 | W 5-4 | 75-52 | 1 | 49,064 | Tommy John | Steve Carlton | Tommy John | Warren Brusstar | Charlie Hough | 578 | 454 | 124 |
| 1978-08-25 | vs PHI | 128 | W 6-5 | 76-52 | 1 | 46,548 | Don Sutton | Dick Ruthven | Lance Rautzhan | Ron Reed | | 584 | 459 | 125 |
| 1978-08-26 | vs PHI | 129 | L 1-3 | 76-53 | 1 | 50,194 | Doug Rau | Randy Lerch | Randy Lerch | Doug Rau | | 585 | 462 | 123 |
| 1978-08-27 | vs PHI | 130 | L 3-9 | 76-54 | 1 | 43,065 | Bob Welch | Larry Christenson | Larry Christenson | Bob Welch | | 588 | 471 | 117 |
| 1978-08-28 | vs MON | 131 | W 4-0 | 77-54 | 1 | 30,984 | Burt Hooton | Steve Rogers | Burt Hooton | Steve Rogers | | 592 | 471 | 121 |
| 1978-08-29 | vs MON | 132 | W 4-1 | 78-54 | 1 | 37,179 | Tommy John | Hal Dues | Tommy John | Hal Dues | | 596 | 472 | 124 |
| 1978-08-30 | vs MON | 133 | W 4-3 | 79-54 | 1 | 41,469 | Don Sutton | Dan Schatzeder | Charlie Hough | Wayne Twitchell | | 600 | 475 | 125 |
| 1978-09-01 | vs NYN | 134 | W 4-3 | 80-54 | 1 | 33,292 | Doug Rau | Jerry Koosman | Terry Forster | Kevin Kobel | | 604 | 478 | 126 |
| 1978-09-02 | vs NYN | 135 | W 3-2 | 81-55 | 1 | 0 | Burt Hooton | Mike Bruhert | Burt Hooton | Mike Bruhert | | 607 | 480 | 127 |
| 1978-09-02 | vs NYN | 136 | L 3-5 | 81-55 | 1 | 49,818 | Bob Welch | Nino Espinosa | Dale Murray | Charlie Hough | | 610 | 485 | 125 |
| 1978-09-03 | vs NYN | 137 | L 5-8 | 81-56 | 1 | 26,983 | Tommy John | Tom Hausman | Tom Hausman | Tommy John | | 615 | 493 | 122 |
| 1978-09-04 | vs SFN | 138 | W 5-4 | 82-56 | 1 | 52,589 | Don Sutton | Ed Halicki | Don Sutton | Ed Halicki | Terry Forster | 620 | 497 | 123 |
| 1978-09-06 | vs SFN | 139 | W 9-2 | 83-56 | 1 | 27,211 | Doug Rau | Jim Barr | Doug Rau | Jim Barr | | 629 | 499 | 130 |
| 1978-09-07 | @ HOU | 140 | W 3-2 | 84-56 | 1 | 7,846 | Burt Hooton | Mark Lemongello | Burt Hooton | Mark Lemongello | Terry Forster | 632 | 501 | 131 |
| 1978-09-08 | @ HOU | 141 | L 0-5 | 84-57 | 1 | 12,905 | Bob Welch | Ken Forsch | Ken Forsch | Bob Welch | | 632 | 506 | 126 |
| 1978-09-09 | @ ATL | 142 | L 4-7 | 84-58 | 1 | 26,777 | Tommy John | Phil Niekro | Phil Niekro | Rick Rhoden | Gene Garber | 636 | 513 | 123 |
| 1978-09-10 | @ ATL | 143 | W 11-5 | 85-58 | 1 | 11,108 | Don Sutton | Jim Bouton | Don Sutton | Jim Bouton | | 647 | 518 | 129 |
| 1978-09-11 | @ SFN | 144 | W 7-2 | 86-58 | 1 | 35,965 | Doug Rau | Vida Blue | Doug Rau | Vida Blue | Terry Forster | 654 | 520 | 134 |
| 1978-09-12 | @ SFN | 145 | W 8-0 | 87-58 | 1 | 38,073 | Burt Hooton | John Montefusco | Burt Hooton | John Montefusco | | 662 | 520 | 142 |
| 1978-09-13 | vs HOU | 146 | W 6-0 | 88-58 | 1 | 27,063 | Bob Welch | Ken Forsch | Bob Welch | Ken Forsch | | 668 | 520 | 148 |
| 1978-09-14 | vs HOU | 147 | W 2-1 | 89-58 | 1 | 37,423 | Rick Rhoden | Joe Niekro | Rick Rhoden | Joe Niekro | Terry Forster | 670 | 521 | 149 |
| 1978-09-15 | vs ATL | 148 | W 5-0 | 90-58 | 1 | 47,188 | Don Sutton | Eddie Solomon | Don Sutton | Eddie Solomon | | 675 | 521 | 154 |
| 1978-09-16 | vs ATL | 149 | W 2-0 | 91-58 | 1 | 35,834 | Doug Rau | Larry McWilliams | Doug Rau | Larry McWilliams | Terry Forster | 677 | 521 | 156 |
| 1978-09-17 | vs ATL | 150 | L 2-3 | 91-59 | 1 | 27,993 | Burt Hooton | Phil Niekro | Phil Niekro | Burt Hooton | Gene Garber | 679 | 524 | 155 |
| 1978-09-18 | vs CIN | 151 | L 0-4 | 91-60 | 1 | 50,292 | Bob Welch | Mike LaCoss | Mike LaCoss | Bob Welch | | 679 | 528 | 151 |
| 1978-09-19 | vs CIN | 152 | W 8-0 | 92-60 | 1 | 50,450 | Rick Rhoden | Fred Norman | Rick Rhoden | Fred Norman | | 687 | 528 | 159 |
| 1978-09-20 | vs CIN | 153 | L 3-4 | 92-61 | 1 | 51,494 | Don Sutton | Tom Seaver | Tom Seaver | Don Sutton | Doug Bair | 690 | 532 | 158 |
| 1978-09-22 | vs SDN | 154 | L 3-12 | 92-62 | 1 | 38,743 | Doug Rau | Randy Jones | Randy Jones | Doug Rau | Bob Shirley | 693 | 544 | 149 |
| 1978-09-23 | vs SDN | 155 | W 5-3 | 93-62 | 1 | 31,653 | Burt Hooton | John D'Acquisto | Burt Hooton | Rollie Fingers | Terry Forster | 698 | 547 | 151 |
| 1978-09-24 | vs SDN | 156 | W 4-0 | 94-62 | 1 | 50,018 | Bob Welch | Bob Owchinko | Bob Welch | Bob Owchinko | | 702 | 547 | 155 |
| 1978-09-26 | @ CIN | 157 | L 4-6 | 94-63 | 1 | 27,189 | Rick Rhoden | Tom Seaver | Tom Seaver | Rick Rhoden | | 706 | 553 | 153 |
| 1978-09-27 | @ CIN | 158 | L 3-5 | 94-64 | 1 | 26,028 | Don Sutton | Mario Soto | Pedro Borbon | Charlie Hough | Doug Bair | 709 | 558 | 151 |
| 1978-09-28 | @ CIN | 159 | L 7-8 | 94-65 | 1 | 25,314 | Doug Rau | Mike LaCoss | Dave Tomlin | Lance Rautzhan | | 716 | 566 | 150 |
| 1978-09-29 | @ SDN | 160 | L 1-3 | 94-66 | 1 | 26,002 | Burt Hooton | John D'Acquisto | John D'Acquisto | Burt Hooton | Rollie Fingers | 717 | 569 | 148 |
| 1978-09-30 | @ SDN | 161 | W 7-0 | 95-66 | 1 | 38,539 | Tommy John | Steve Mura | Tommy John | Steve Mura | | 724 | 569 | 155 |
| 1978-10-01 | @ SDN | 162 | L 3-4 | 95-67 | 1 | 37,185 | Don Sutton | Gaylord Perry | Rollie Fingers | Bobby Castillo | | 727 | 573 | 154 |