| 1978-04-06 | @ CIN | 1 | L 9-11 | - | | 52,378 | J.R. Richard | Tom Seaver | Pedro Borbon | J.R. Richard | Dave Tomlin | 9 | 11 | -2 |
| 1978-04-07 | @ CIN | 2 | L 4-5 | - | | 22,883 | Joe Niekro | Bill Bonham | Bill Bonham | Joe Niekro | Pedro Borbon | 13 | 16 | -3 |
| 1978-04-08 | @ CIN | 3 | L 1-2 | - | | 17,958 | Joaquin Andujar | Fred Norman | Fred Norman | Joaquin Andujar | Doug Bair | 14 | 18 | -4 |
| 1978-04-09 | @ CIN | 4 | L 3-9 | - | | 42,667 | Mark Lemongello | Tom Hume | Tom Hume | Mark Lemongello | | 17 | 27 | -10 |
| 1978-04-10 | vs LAN | 5 | L 2-5 | - | | 22,882 | Floyd Bannister | Doug Rau | Doug Rau | Floyd Bannister | Terry Forster | 19 | 32 | -13 |
| 1978-04-11 | vs LAN | 6 | W 1-0 | - | | 11,049 | J.R. Richard | Burt Hooton | J.R. Richard | Burt Hooton | | 20 | 32 | -12 |
| 1978-04-12 | vs LAN | 7 | W 11-10 | - | | 11,824 | Joe Niekro | Don Sutton | Joe Sambito | Bobby Castillo | | 31 | 42 | -11 |
| 1978-04-14 | vs CIN | 8 | L 4-8 | - | | 25,583 | Joaquin Andujar | Tom Hume | Tom Hume | Joaquin Andujar | Dale Murray | 35 | 50 | -15 |
| 1978-04-15 | vs CIN | 9 | W 6-1 | - | | 34,858 | Mark Lemongello | Doug Capilla | Mark Lemongello | Doug Capilla | | 41 | 51 | -10 |
| 1978-04-16 | vs CIN | 10 | W 4-3 | - | | 27,700 | J.R. Richard | Tom Seaver | Tom Dixon | Manny Sarmiento | | 45 | 54 | -9 |
| 1978-04-18 | @ SDN | 11 | W 5-1 | - | | 10,840 | Joe Niekro | Bob Shirley | Joe Niekro | Bob Shirley | | 50 | 55 | -5 |
| 1978-04-19 | @ SDN | 12 | W 2-1 | - | | 12,129 | Joaquin Andujar | Dave Freisleben | Joaquin Andujar | Dave Freisleben | Joe Sambito | 52 | 56 | -4 |
| 1978-04-20 | @ LAN | 13 | L 1-5 | - | | 24,049 | Mark Lemongello | Doug Rau | Doug Rau | Mark Lemongello | | 53 | 61 | -8 |
| 1978-04-21 | @ LAN | 14 | W 8-6 | - | | 44,867 | J.R. Richard | Rick Rhoden | Ken Forsch | Bobby Castillo | | 61 | 67 | -6 |
| 1978-04-22 | @ LAN | 15 | L 1-5 | - | | 52,346 | Floyd Bannister | Burt Hooton | Burt Hooton | Floyd Bannister | | 62 | 72 | -10 |
| 1978-04-23 | @ LAN | 16 | L 3-7 | - | | 51,500 | Joe Niekro | Don Sutton | Don Sutton | Joe Niekro | | 65 | 79 | -14 |
| 1978-04-24 | vs SDN | 17 | W 4-3 | - | | 7,300 | Joaquin Andujar | Dave Freisleben | Joe Sambito | Rollie Fingers | | 69 | 82 | -13 |
| 1978-04-25 | vs SDN | 18 | W 4-3 | - | | 7,459 | Mark Lemongello | Randy Jones | Mark Lemongello | Randy Jones | | 73 | 85 | -12 |
| 1978-04-26 | vs SDN | 19 | L 1-2 | - | | 8,769 | J.R. Richard | Gaylord Perry | Gaylord Perry | J.R. Richard | Rollie Fingers | 74 | 87 | -13 |
| 1978-04-28 | vs MON | 20 | L 3-6 | - | | 11,474 | Joe Niekro | Ross Grimsley | Ross Grimsley | Joe Niekro | | 77 | 93 | -16 |
| 1978-04-29 | vs MON | 21 | W 3-1 | - | | 46,215 | Joaquin Andujar | Steve Rogers | Joaquin Andujar | Steve Rogers | | 80 | 94 | -14 |
| 1978-04-30 | vs MON | 22 | L 1-2 | - | | 11,515 | Mark Lemongello | Rudy May | Rudy May | Mark Lemongello | Stan Bahnsen | 81 | 96 | -15 |
| 1978-05-03 | @ MON | 23 | L 3-10 | - | | 5,229 | J.R. Richard | Ross Grimsley | Ross Grimsley | J.R. Richard | | 84 | 106 | -22 |
| 1978-05-05 | @ ATL | 24 | L 2-5 | - | | 5,699 | Joe Niekro | Tommy Boggs | Tommy Boggs | Joe Niekro | Eddie Solomon | 86 | 111 | -25 |
| 1978-05-06 | @ ATL | 25 | L 1-2 | - | | 7,901 | Joaquin Andujar | Preston Hanna | Dave Campbell | Ken Forsch | | 87 | 113 | -26 |
| 1978-05-09 | @ PHI | 26 | W 5-1 | - | | 18,144 | J.R. Richard | Larry Christenson | J.R. Richard | Larry Christenson | | 92 | 114 | -22 |
| 1978-05-10 | @ PHI | 27 | L 1-3 | - | | 20,096 | Mark Lemongello | Jim Lonborg | Jim Lonborg | Mark Lemongello | | 93 | 117 | -24 |
| 1978-05-12 | @ NYN | 28 | W 5-4 | - | | 8,649 | Joaquin Andujar | Craig Swan | Tom Dixon | Skip Lockwood | | 98 | 121 | -23 |
| 1978-05-13 | @ NYN | 29 | W 7-4 | - | | 19,838 | Joe Niekro | Mike Bruhert | Joe Niekro | Mike Bruhert | Joe Sambito | 105 | 125 | -20 |
| 1978-05-15 | vs PHI | 30 | W 5-0 | - | | 9,943 | J.R. Richard | Jim Lonborg | J.R. Richard | Jim Lonborg | | 110 | 125 | -15 |
| 1978-05-16 | vs PHI | 31 | W 6-1 | - | | 11,381 | Mark Lemongello | Steve Carlton | Mark Lemongello | Steve Carlton | | 116 | 126 | -10 |
| 1978-05-17 | vs PHI | 32 | W 2-1 | - | | 11,856 | Joaquin Andujar | Randy Lerch | Joaquin Andujar | Randy Lerch | Tom Dixon | 118 | 127 | -9 |
| 1978-05-18 | vs PHI | 33 | L 5-8 | - | | 10,828 | Joe Niekro | Larry Christenson | Gene Garber | Joe Sambito | | 123 | 135 | -12 |
| 1978-05-19 | vs ATL | 34 | W 6-0 | - | | 15,609 | Floyd Bannister | Dick Ruthven | Floyd Bannister | Dick Ruthven | | 129 | 135 | -6 |
| 1978-05-20 | vs ATL | 35 | W 13-0 | - | | 24,402 | J.R. Richard | Tommy Boggs | J.R. Richard | Tommy Boggs | | 142 | 135 | 7 |
| 1978-05-21 | vs ATL | 36 | L 4-6 | - | | 11,715 | Mark Lemongello | Phil Niekro | Phil Niekro | Mark Lemongello | Adrian Devine | 146 | 141 | 5 |
| 1978-05-23 | @ SFN | 37 | L 2-3 | - | | 11,120 | Tom Dixon | Vida Blue | Randy Moffitt | Joe Sambito | | 148 | 144 | 4 |
| 1978-05-24 | @ SFN | 38 | L 0-2 | - | | 6,158 | Floyd Bannister | John Montefusco | John Montefusco | Ken Forsch | Gary Lavelle | 148 | 146 | 2 |
| 1978-05-25 | @ SFN | 39 | L 1-9 | - | | 6,209 | J.R. Richard | Ed Halicki | Ed Halicki | J.R. Richard | | 149 | 155 | -6 |
| 1978-05-26 | vs NYN | 40 | W 5-4 | - | | 11,158 | Mark Lemongello | Jerry Koosman | Mark Lemongello | Jerry Koosman | Ken Forsch | 154 | 159 | -5 |
| 1978-05-27 | vs NYN | 41 | L 7-9 | - | | 26,742 | Joaquin Andujar | Mike Bruhert | Butch Metzger | Joe Sambito | Dale Murray | 161 | 168 | -7 |
| 1978-05-28 | vs NYN | 42 | L 1-4 | - | | 12,133 | Tom Dixon | Nino Espinosa | Nino Espinosa | Tom Dixon | | 162 | 172 | -10 |
| 1978-05-29 | vs SFN | 43 | L 1-8 | - | | 10,012 | Floyd Bannister | Ed Halicki | Ed Halicki | Floyd Bannister | | 163 | 180 | -17 |
| 1978-05-30 | vs SFN | 44 | L 0-1 | - | | 8,019 | J.R. Richard | Bob Knepper | Bob Knepper | J.R. Richard | | 163 | 181 | -18 |
| 1978-05-31 | vs SFN | 45 | W 1-0 | - | | 11,400 | Mark Lemongello | Vida Blue | Mark Lemongello | Vida Blue | | 164 | 181 | -17 |
| 1978-06-02 | vs SLN | 46 | W 2-1 | - | | 10,315 | Joaquin Andujar | John Denny | Joe Sambito | John Denny | | 166 | 182 | -16 |
| 1978-06-03 | vs SLN | 47 | W 5-2 | - | | 0 | Floyd Bannister | Pete Falcone | Floyd Bannister | Pete Falcone | Ken Forsch | 171 | 184 | -13 |
| 1978-06-03 | vs SLN | 48 | L 1-2 | - | | 27,822 | Tom Dixon | Pete Vuckovich | Pete Vuckovich | Tom Dixon | | 172 | 186 | -14 |
| 1978-06-04 | vs SLN | 49 | L 2-4 | - | | 10,238 | J.R. Richard | Silvio Martinez | Silvio Martinez | J.R. Richard | Buddy Schultz | 174 | 190 | -16 |
| 1978-06-05 | @ CHN | 50 | L 1-2 | - | | 10,201 | Mark Lemongello | Dennis Lamp | Guillermo Hernandez | Mark Lemongello | | 175 | 192 | -17 |
| 1978-06-06 | @ CHN | 51 | L 4-9 | - | | 14,107 | Joaquin Andujar | Dave Roberts | Dave Roberts | Joaquin Andujar | | 179 | 201 | -22 |
| 1978-06-09 | @ SLN | 52 | W 11-7 | - | | 40,764 | J.R. Richard | Silvio Martinez | J.R. Richard | George Frazier | Ken Forsch | 190 | 208 | -18 |
| 1978-06-10 | @ SLN | 53 | W 12-5 | - | | 18,485 | Mark Lemongello | Bob Forsch | Mark Lemongello | Bob Forsch | | 202 | 213 | -11 |
| 1978-06-11 | @ SLN | 54 | L 3-5 | - | | 17,298 | Joaquin Andujar | John Denny | John Denny | Joaquin Andujar | | 205 | 218 | -13 |
| 1978-06-12 | vs PIT | 55 | W 6-5 | - | | 9,886 | Tom Dixon | John Candelaria | Rick Williams | Ed Whitson | Joe Sambito | 211 | 223 | -12 |
| 1978-06-13 | vs PIT | 56 | W 2-1 | - | | 10,487 | Floyd Bannister | Jim Bibby | Ken Forsch | Jim Bibby | Joe Sambito | 213 | 224 | -11 |
| 1978-06-14 | vs PIT | 57 | L 4-6 | - | | 12,440 | J.R. Richard | Don Robinson | Ed Whitson | J.R. Richard | Kent Tekulve | 217 | 230 | -13 |
| 1978-06-16 | vs CHN | 58 | L 6-7 | - | | 18,948 | Mark Lemongello | Ray Burris | Paul Reuschel | Rick Williams | | 223 | 237 | -14 |
| 1978-06-17 | vs CHN | 59 | W 5-4 | - | | 28,091 | Joaquin Andujar | Dave Geisel | Joe Niekro | Guillermo Hernandez | | 228 | 241 | -13 |
| 1978-06-18 | vs CHN | 60 | W 3-1 | - | | 14,770 | Tom Dixon | Dennis Lamp | Tom Dixon | Dennis Lamp | Joe Sambito | 231 | 242 | -11 |
| 1978-06-20 | @ LAN | 61 | W 5-3 | - | | 41,991 | J.R. Richard | Tommy John | J.R. Richard | Tommy John | Bo McLaughlin | 236 | 245 | -9 |
| 1978-06-21 | @ LAN | 62 | L 4-5 | - | | 34,975 | Mark Lemongello | Rick Rhoden | Bob Welch | Joe Sambito | | 240 | 250 | -10 |
| 1978-06-22 | @ LAN | 63 | W 4-3 | - | | 31,246 | Joe Niekro | Doug Rau | Joe Niekro | Doug Rau | | 244 | 253 | -9 |
| 1978-06-23 | @ SDN | 64 | L 0-3 | - | | 12,055 | Tom Dixon | Gaylord Perry | Gaylord Perry | Tom Dixon | | 244 | 256 | -12 |
| 1978-06-24 | @ SDN | 65 | L 5-6 | - | | 15,759 | Floyd Bannister | Randy Jones | Rollie Fingers | Ken Forsch | | 249 | 262 | -13 |
| 1978-06-25 | @ SDN | 66 | L 1-6 | - | | 0 | J.R. Richard | Bob Shirley | Bob Shirley | J.R. Richard | | 250 | 268 | -18 |
| 1978-06-25 | @ SDN | 67 | L 4-7 | - | | 20,342 | Bo McLaughlin | Eric Rasmussen | Eric Rasmussen | Bo McLaughlin | John D'Acquisto | 254 | 275 | -21 |
| 1978-06-26 | vs CIN | 68 | L 3-4 | - | | 20,388 | Mark Lemongello | Tom Seaver | Tom Seaver | Mark Lemongello | Dave Tomlin | 257 | 279 | -22 |
| 1978-06-27 | vs CIN | 69 | W 7-4 | - | | 16,848 | Joe Niekro | Bill Bonham | Joe Niekro | Bill Bonham | Joe Sambito | 264 | 283 | -19 |
| 1978-06-28 | vs CIN | 70 | W 3-0 | - | | 16,622 | Tom Dixon | Fred Norman | Tom Dixon | Fred Norman | | 267 | 283 | -16 |
| 1978-06-29 | vs CIN | 71 | W 5-0 | - | | 17,564 | Floyd Bannister | Tom Hume | Floyd Bannister | Tom Hume | | 272 | 283 | -11 |
| 1978-06-30 | vs SDN | 72 | L 2-5 | - | | 9,194 | J.R. Richard | Bob Shirley | Bob Shirley | J.R. Richard | Rollie Fingers | 274 | 288 | -14 |
| 1978-07-01 | vs SDN | 73 | W 9-2 | - | | 0 | Mark Lemongello | Bob Owchinko | Mark Lemongello | Bob Owchinko | | 283 | 290 | -7 |
| 1978-07-01 | vs SDN | 74 | L 3-9 | - | | 22,076 | Joe Niekro | Mark Wiley | Mark Wiley | Joe Niekro | John D'Acquisto | 286 | 299 | -13 |
| 1978-07-02 | vs SDN | 75 | L 2-6 | - | | 14,737 | Tom Dixon | Gaylord Perry | Gaylord Perry | Tom Dixon | Rollie Fingers | 288 | 305 | -17 |
| 1978-07-03 | @ CIN | 76 | L 7-8 | - | | 31,840 | Floyd Bannister | Fred Norman | Doug Bair | Joe Sambito | | 295 | 313 | -18 |
| 1978-07-04 | @ CIN | 77 | W 3-1 | - | | 31,705 | J.R. Richard | Tom Hume | J.R. Richard | Tom Hume | | 298 | 314 | -16 |
| 1978-07-05 | @ CIN | 78 | L 1-2 | - | | 30,320 | Joe Niekro | Paul Moskau | Paul Moskau | Joe Niekro | Doug Bair | 299 | 316 | -17 |
| 1978-07-07 | vs LAN | 79 | L 4-7 | - | | 20,707 | Mark Lemongello | Doug Rau | Doug Rau | Mark Lemongello | Charlie Hough | 303 | 323 | -20 |
| 1978-07-08 | vs LAN | 80 | L 1-7 | - | | 0 | Floyd Bannister | Burt Hooton | Burt Hooton | Floyd Bannister | | 304 | 330 | -26 |
| 1978-07-08 | vs LAN | 81 | L 5-7 | - | | 37,073 | Tom Dixon | Bob Welch | Tommy John | Tom Dixon | | 309 | 337 | -28 |
| 1978-07-09 | vs LAN | 82 | W 5-1 | - | | 30,285 | J.R. Richard | Don Sutton | J.R. Richard | Don Sutton | | 314 | 338 | -24 |
| 1978-07-13 | @ MON | 83 | L 0-6 | - | | 15,337 | Joe Niekro | Ross Grimsley | Ross Grimsley | Joe Niekro | | 314 | 344 | -30 |
| 1978-07-14 | @ MON | 84 | W 4-3 | - | | 0 | J.R. Richard | Steve Rogers | Ken Forsch | Stan Bahnsen | | 318 | 347 | -29 |
| 1978-07-14 | @ MON | 85 | W 5-4 | - | | 21,696 | Mark Lemongello | Hal Dues | Ken Forsch | Gerry Pirtle | Bo McLaughlin | 323 | 351 | -28 |
| 1978-07-15 | @ MON | 86 | L 0-8 | - | | 15,360 | Tom Dixon | Woodie Fryman | Woodie Fryman | Tom Dixon | | 323 | 359 | -36 |
| 1978-07-16 | @ MON | 87 | L 1-6 | - | | 21,440 | Floyd Bannister | Dan Schatzeder | Dan Schatzeder | Floyd Bannister | | 324 | 365 | -41 |
| 1978-07-17 | vs PHI | 88 | W 2-1 | - | | 14,397 | Joe Niekro | Larry Christenson | Joe Niekro | Rawly Eastwick | | 326 | 366 | -40 |
| 1978-07-18 | vs PHI | 89 | W 9-1 | - | | 15,478 | J.R. Richard | Jim Lonborg | J.R. Richard | Jim Lonborg | | 335 | 367 | -32 |
| 1978-07-19 | @ NYN | 90 | W 8-3 | - | | 0 | Tom Dixon | Pat Zachry | Tom Dixon | Pat Zachry | Joe Sambito | 343 | 370 | -27 |
| 1978-07-19 | @ NYN | 91 | L 1-2 | - | | 13,539 | Mark Lemongello | Craig Swan | Craig Swan | Mark Lemongello | | 344 | 372 | -28 |
| 1978-07-20 | @ NYN | 92 | L 4-7 | - | | 0 | Floyd Bannister | Mike Bruhert | Mike Bruhert | Floyd Bannister | Skip Lockwood | 348 | 379 | -31 |
| 1978-07-20 | @ NYN | 93 | L 4-5 | - | | 13,341 | Vern Ruhle | Dwight Bernard | Dale Murray | Joe Sambito | | 352 | 384 | -32 |
| 1978-07-21 | @ PHI | 94 | L 1-6 | - | | 0 | Joe Niekro | Dick Ruthven | Dick Ruthven | Joe Niekro | | 353 | 390 | -37 |
| 1978-07-21 | @ PHI | 95 | L 2-8 | - | | 35,389 | Rick Williams | Larry Christenson | Larry Christenson | Rick Williams | | 355 | 398 | -43 |
| 1978-07-22 | @ PHI | 96 | L 2-3 | - | | 33,672 | J.R. Richard | Randy Lerch | Ron Reed | Ken Forsch | | 357 | 401 | -44 |
| 1978-07-23 | @ PHI | 97 | L 2-13 | - | | 30,554 | Tom Dixon | Steve Carlton | Steve Carlton | Tom Dixon | | 359 | 414 | -55 |
| 1978-07-24 | vs MON | 98 | W 6-5 | - | | 7,843 | Mark Lemongello | Hal Dues | Ken Forsch | Darold Knowles | | 365 | 419 | -54 |
| 1978-07-25 | vs MON | 99 | W 3-2 | - | | 8,383 | Vern Ruhle | Woodie Fryman | Ken Forsch | Wayne Twitchell | | 368 | 421 | -53 |
| 1978-07-26 | vs MON | 100 | W 5-0 | - | | 8,465 | Joe Niekro | Ross Grimsley | Joe Niekro | Ross Grimsley | | 373 | 421 | -48 |
| 1978-07-27 | vs NYN | 101 | W 8-3 | - | | 9,730 | J.R. Richard | Tom Hausman | J.R. Richard | Tom Hausman | | 381 | 424 | -43 |
| 1978-07-28 | vs NYN | 102 | W 4-3 | - | | 26,779 | Tom Dixon | Jerry Koosman | Joe Sambito | Skip Lockwood | | 385 | 427 | -42 |
| 1978-07-30 | vs NYN | 103 | W 4-3 | - | | 17,502 | Mark Lemongello | Craig Swan | Joaquin Andujar | Dwight Bernard | | 389 | 430 | -41 |
| 1978-07-31 | vs SFN | 104 | W 4-1 | - | | 12,900 | Joe Niekro | Ed Halicki | Joe Niekro | Ed Halicki | | 393 | 431 | -38 |
| 1978-08-01 | vs SFN | 105 | W 4-2 | - | | 16,515 | J.R. Richard | Bob Knepper | J.R. Richard | Bob Knepper | Joe Sambito | 397 | 433 | -36 |
| 1978-08-02 | vs SFN | 106 | L 2-4 | - | | 14,754 | Tom Dixon | John Montefusco | John Montefusco | Tom Dixon | | 399 | 437 | -38 |
| 1978-08-04 | @ ATL | 107 | L 2-7 | - | | 11,282 | Mark Lemongello | Phil Niekro | Phil Niekro | Mark Lemongello | | 401 | 444 | -43 |
| 1978-08-05 | @ ATL | 108 | W 5-3 | - | | 0 | Joe Niekro | Preston Hanna | Joe Niekro | Preston Hanna | Ken Forsch | 406 | 447 | -41 |
| 1978-08-05 | @ ATL | 109 | W 7-0 | - | | 20,950 | Vern Ruhle | Tommy Boggs | Vern Ruhle | Tommy Boggs | | 413 | 447 | -34 |
| 1978-08-06 | @ ATL | 110 | L 2-3 | - | | 8,551 | J.R. Richard | Larry McWilliams | Larry McWilliams | J.R. Richard | Gene Garber | 415 | 450 | -35 |
| 1978-08-08 | @ SFN | 111 | L 2-3 | - | | 31,904 | Tom Dixon | John Montefusco | John Montefusco | Tom Dixon | Randy Moffitt | 417 | 453 | -36 |
| 1978-08-09 | @ SFN | 112 | W 6-5 | - | | 13,757 | Mark Lemongello | Jim Barr | Mark Lemongello | Jim Barr | Ken Forsch | 423 | 458 | -35 |
| 1978-08-11 | vs ATL | 113 | L 0-1 | - | | 16,035 | Joe Niekro | Larry McWilliams | Larry McWilliams | Joe Niekro | Gene Garber | 423 | 459 | -36 |
| 1978-08-12 | vs ATL | 114 | W 5-2 | - | | 25,023 | J.R. Richard | Phil Niekro | J.R. Richard | Phil Niekro | | 428 | 461 | -33 |
| 1978-08-13 | vs ATL | 115 | W 3-0 | - | | 15,878 | Vern Ruhle | Preston Hanna | Vern Ruhle | Preston Hanna | | 431 | 461 | -30 |
| 1978-08-14 | @ SLN | 116 | W 6-0 | - | | 12,555 | Tom Dixon | Bob Forsch | Tom Dixon | Bob Forsch | | 437 | 461 | -24 |
| 1978-08-15 | @ SLN | 117 | L 5-11 | - | | 12,606 | Floyd Bannister | Aurelio Lopez | Aurelio Lopez | Floyd Bannister | | 442 | 472 | -30 |
| 1978-08-16 | @ SLN | 118 | W 4-2 | - | | 10,829 | Joe Niekro | Silvio Martinez | Joe Niekro | Silvio Martinez | | 446 | 474 | -28 |
| 1978-08-17 | @ PIT | 119 | L 1-5 | - | | 0 | J.R. Richard | Don Robinson | Don Robinson | J.R. Richard | | 447 | 479 | -32 |
| 1978-08-17 | @ PIT | 120 | L 2-3 | - | | 8,470 | Mark Lemongello | Bruce Kison | Bruce Kison | Mark Lemongello | Kent Tekulve | 449 | 482 | -33 |
| 1978-08-18 | @ PIT | 121 | L 3-6 | - | | 8,632 | Vern Ruhle | Jim Bibby | Jim Bibby | Vern Ruhle | Kent Tekulve | 452 | 488 | -36 |
| 1978-08-19 | @ PIT | 122 | L 2-4 | - | | 22,015 | Floyd Bannister | Bert Blyleven | Bert Blyleven | Floyd Bannister | Kent Tekulve | 454 | 492 | -38 |
| 1978-08-20 | @ PIT | 123 | L 6-7 | - | | 0 | Tom Dixon | Jim Rooker | Jim Rooker | Tom Dixon | Kent Tekulve | 460 | 499 | -39 |
| 1978-08-20 | @ PIT | 124 | L 1-3 | - | | 21,851 | Joe Niekro | Jerry Reuss | Jerry Reuss | Joe Niekro | | 461 | 502 | -41 |
| 1978-08-21 | vs CHN | 125 | W 8-3 | - | | 9,906 | J.R. Richard | Rick Reuschel | J.R. Richard | Rick Reuschel | | 469 | 505 | -36 |
| 1978-08-22 | vs CHN | 126 | W 2-1 | - | | 9,721 | Mark Lemongello | Mike Krukow | Mark Lemongello | Mike Krukow | | 471 | 506 | -35 |
| 1978-08-23 | vs CHN | 127 | W 3-0 | - | | 9,217 | Ken Forsch | Dennis Lamp | Ken Forsch | Dennis Lamp | Joe Sambito | 474 | 506 | -32 |
| 1978-08-25 | vs PIT | 128 | W 7-5 | - | | 11,641 | Joe Niekro | Jim Rooker | Joe Niekro | Jim Rooker | Joaquin Andujar | 481 | 511 | -30 |
| 1978-08-26 | vs PIT | 129 | W 7-2 | - | | 9,985 | J.R. Richard | Bruce Kison | J.R. Richard | Bruce Kison | | 488 | 513 | -25 |
| 1978-08-27 | vs PIT | 130 | L 5-8 | - | | 10,947 | Mark Lemongello | Don Robinson | Grant Jackson | Mark Lemongello | Kent Tekulve | 493 | 521 | -28 |
| 1978-08-29 | vs SLN | 131 | W 6-3 | - | | 6,692 | Ken Forsch | Pete Vuckovich | Ken Forsch | Pete Vuckovich | | 499 | 524 | -25 |
| 1978-08-30 | vs SLN | 132 | L 2-4 | - | | 6,480 | Joe Niekro | Bob Forsch | Bob Forsch | Joe Niekro | | 501 | 528 | -27 |
| 1978-09-01 | @ CHN | 133 | L 11-14 | - | | 16,117 | J.R. Richard | Mike Krukow | Guillermo Hernandez | Joe Sambito | Bruce Sutter | 512 | 542 | -30 |
| 1978-09-02 | @ CHN | 134 | W 8-5 | - | | 24,064 | Mark Lemongello | Rick Reuschel | Joaquin Andujar | Bruce Sutter | Joe Sambito | 520 | 547 | -27 |
| 1978-09-03 | @ CHN | 135 | L 2-3 | - | | 0 | Ken Forsch | Dennis Lamp | Dennis Lamp | Ken Forsch | Guillermo Hernandez | 522 | 550 | -28 |
| 1978-09-03 | @ CHN | 136 | L 2-4 | - | | 29,528 | Vern Ruhle | Manny Seoane | Donnie Moore | Vern Ruhle | Guillermo Hernandez | 524 | 554 | -30 |
| 1978-09-04 | vs CIN | 137 | L 3-6 | - | | 11,090 | Joe Niekro | Bill Bonham | Bill Bonham | Joe Niekro | Doug Bair | 527 | 560 | -33 |
| 1978-09-05 | vs CIN | 138 | W 3-2 | - | | 8,811 | J.R. Richard | Tom Seaver | J.R. Richard | Tom Seaver | | 530 | 562 | -32 |
| 1978-09-07 | vs LAN | 139 | L 2-3 | - | | 7,846 | Mark Lemongello | Burt Hooton | Burt Hooton | Mark Lemongello | Terry Forster | 532 | 565 | -33 |
| 1978-09-08 | vs LAN | 140 | W 5-0 | - | | 12,905 | Ken Forsch | Bob Welch | Ken Forsch | Bob Welch | | 537 | 565 | -28 |
| 1978-09-09 | vs SDN | 141 | W 10-4 | - | | 8,240 | Joe Niekro | Steve Mura | Joe Niekro | Steve Mura | | 547 | 569 | -22 |
| 1978-09-10 | vs SDN | 142 | W 3-2 | - | | 5,720 | J.R. Richard | Eric Rasmussen | J.R. Richard | Eric Rasmussen | | 550 | 571 | -21 |
| 1978-09-11 | @ CIN | 143 | L 8-9 | - | | 20,400 | Vern Ruhle | Fred Norman | Dave Tomlin | Joaquin Andujar | | 558 | 580 | -22 |
| 1978-09-12 | @ CIN | 144 | L 3-4 | - | | 20,801 | Mark Lemongello | Paul Moskau | Doug Bair | Joe Sambito | | 561 | 584 | -23 |
| 1978-09-13 | @ LAN | 145 | L 0-6 | - | | 27,063 | Ken Forsch | Bob Welch | Bob Welch | Ken Forsch | | 561 | 590 | -29 |
| 1978-09-14 | @ LAN | 146 | L 1-2 | - | | 37,423 | Joe Niekro | Rick Rhoden | Rick Rhoden | Joe Niekro | Terry Forster | 562 | 592 | -30 |
| 1978-09-15 | @ SDN | 147 | W 8-4 | - | | 6,866 | J.R. Richard | Eric Rasmussen | J.R. Richard | Eric Rasmussen | | 570 | 596 | -26 |
| 1978-09-16 | @ SDN | 148 | L 1-2 | - | | 10,171 | Vern Ruhle | Gaylord Perry | Gaylord Perry | Joe Sambito | | 571 | 598 | -27 |
| 1978-09-17 | @ SDN | 149 | L 1-3 | - | | 10,004 | Mark Lemongello | Randy Jones | Randy Jones | Mark Lemongello | Rollie Fingers | 572 | 601 | -29 |
| 1978-09-19 | vs ATL | 150 | L 2-3 | - | | 5,710 | J.R. Richard | Jim Bouton | Gene Garber | Joaquin Andujar | | 574 | 604 | -30 |
| 1978-09-20 | vs ATL | 151 | L 2-3 | - | | 3,950 | Joe Niekro | Frank LaCorte | Gene Garber | Joe Niekro | | 576 | 607 | -31 |
| 1978-09-21 | vs ATL | 152 | W 2-0 | - | | 3,775 | Ken Forsch | Phil Niekro | Ken Forsch | Phil Niekro | | 578 | 607 | -29 |
| 1978-09-22 | @ SFN | 153 | L 0-2 | - | | 4,510 | Vern Ruhle | Bob Knepper | Bob Knepper | Vern Ruhle | | 578 | 609 | -31 |
| 1978-09-23 | @ SFN | 154 | L 2-3 | - | | 6,433 | J.R. Richard | Ed Halicki | Gary Lavelle | Joaquin Andujar | Randy Moffitt | 580 | 612 | -32 |
| 1978-09-24 | @ SFN | 155 | L 0-7 | - | | 0 | Floyd Bannister | Vida Blue | Vida Blue | Floyd Bannister | | 580 | 619 | -39 |
| 1978-09-24 | @ SFN | 156 | L 4-6 | - | | 25,276 | Tom Dixon | Jim Barr | Jim Barr | Tom Dixon | | 584 | 625 | -41 |
| 1978-09-26 | @ ATL | 157 | W 2-0 | - | | 3,089 | Joe Niekro | Phil Niekro | Joe Niekro | Phil Niekro | Ken Forsch | 586 | 625 | -39 |
| 1978-09-27 | @ ATL | 158 | W 4-0 | - | | 2,710 | Vern Ruhle | Frank LaCorte | Vern Ruhle | Frank LaCorte | | 590 | 625 | -35 |
| 1978-09-28 | @ ATL | 159 | W 4-3 | - | | 2,560 | J.R. Richard | Larry McWilliams | J.R. Richard | Larry McWilliams | Ken Forsch | 594 | 628 | -34 |
| 1978-09-29 | vs SFN | 160 | L 1-2 | - | | 8,339 | Dan Warthen | Ed Halicki | Ed Halicki | Dan Warthen | | 595 | 630 | -35 |
| 1978-09-30 | vs SFN | 161 | W 7-4 | - | | 10,182 | Tom Dixon | Vida Blue | Tom Dixon | Vida Blue | Joe Sambito | 602 | 634 | -32 |
| 1978-10-01 | vs SFN | 162 | W 3-0 | - | | 7,077 | Joe Niekro | Phil Nastu | Joe Niekro | Phil Nastu | Mark Lemongello | 605 | 634 | -29 |