| 1978-04-07 | vs TOR | 1 | W 6-2 | 1-0 | 1 | 52,528 | Mark Fidrych | Dave Lemanczyk | Mark Fidrych | Dave Lemanczyk | | 6 | 2 | 4 |
| 1978-04-08 | vs TOR | 2 | L 2-5 | 1-1 | 3 | 12,413 | Jim Slaton | Jerry Garvin | Jerry Garvin | Jim Slaton | Mike Willis | 8 | 7 | 1 |
| 1978-04-09 | vs TOR | 3 | W 8-4 | 2-1 | 2 | 9,169 | Jack Billingham | Tom Underwood | Jack Billingham | Tom Underwood | Steve Foucault | 16 | 11 | 5 |
| 1978-04-11 | @ TEX | 4 | W 6-2 | 3-1 | 2 | 13,764 | Dave Rozema | Doc Medich | Dave Rozema | Doc Medich | | 22 | 13 | 9 |
| 1978-04-12 | @ TEX | 5 | W 3-2 | 4-1 | 2 | 26,049 | Mark Fidrych | Jon Matlack | Mark Fidrych | Jon Matlack | | 25 | 15 | 10 |
| 1978-04-14 | @ TOR | 6 | L 8-10 | 4-2 | 2 | 35,761 | Jim Slaton | Jerry Garvin | Don Kirkwood | Milt Wilcox | Tom Murphy | 33 | 25 | 8 |
| 1978-04-15 | @ TOR | 7 | W 6-3 | 5-2 | 1 | 15,024 | Jack Billingham | Tom Underwood | Jack Billingham | Mike Willis | Steve Foucault | 39 | 28 | 11 |
| 1978-04-16 | @ TOR | 8 | W 4-3 | 6-2 | 1 | 17,088 | Dave Rozema | Jim Clancy | Jim Crawford | Jim Clancy | | 43 | 31 | 12 |
| 1978-04-17 | vs CHA | 9 | W 10-9 | 7-2 | 1 | 19,841 | Mark Fidrych | Wilbur Wood | John Hiller | Jim Willoughby | | 53 | 40 | 13 |
| 1978-04-22 | vs TEX | 10 | W 7-6 | 8-2 | 1 | 22,054 | Jack Morris | Doyle Alexander | John Hiller | Fergie Jenkins | | 60 | 46 | 14 |
| 1978-04-23 | vs TEX | 11 | W 9-6 | 9-3 | 1 | 0 | Jim Slaton | Jon Matlack | Jim Slaton | Jon Matlack | Steve Foucault | 69 | 52 | 17 |
| 1978-04-23 | vs TEX | 12 | L 1-2 | 9-3 | 1 | 20,615 | Dave Rozema | Jim Umbarger | Len Barker | Jim Crawford | | 70 | 54 | 16 |
| 1978-04-24 | @ CHA | 13 | W 4-1 | 10-3 | 1 | 8,314 | Jack Billingham | Ken Kravec | Jack Billingham | Ken Kravec | | 74 | 55 | 19 |
| 1978-04-25 | @ CHA | 14 | W 8-4 | 11-3 | 1 | 13,496 | Milt Wilcox | Francisco Barrios | John Hiller | Pablo Torrealba | | 82 | 59 | 23 |
| 1978-04-26 | @ CHA | 15 | L 2-7 | 11-4 | 1 | 7,983 | Jack Morris | Wilbur Wood | Wilbur Wood | Jim Crawford | | 84 | 66 | 18 |
| 1978-04-28 | @ SEA | 16 | W 5-4 | 12-4 | 1 | 10,240 | Jim Slaton | Rick Honeycutt | Jim Slaton | Rick Honeycutt | John Hiller | 89 | 70 | 19 |
| 1978-04-29 | @ SEA | 17 | W 5-0 | 13-4 | 1 | 12,123 | Dave Rozema | Paul Mitchell | Dave Rozema | Paul Mitchell | | 94 | 70 | 24 |
| 1978-04-30 | @ SEA | 18 | L 3-4 | 13-5 | 1 | 7,474 | Jack Billingham | Mike Parrott | Enrique Romo | Steve Foucault | | 97 | 74 | 23 |
| 1978-05-02 | @ CAL | 19 | W 10-2 | 14-5 | 1 | 18,641 | Milt Wilcox | Ken Brett | Milt Wilcox | Ken Brett | | 107 | 76 | 31 |
| 1978-05-03 | @ CAL | 20 | W 7-4 | 15-5 | 1 | 19,462 | Jim Slaton | Frank Tanana | Jim Slaton | Frank Tanana | John Hiller | 114 | 80 | 34 |
| 1978-05-05 | @ OAK | 21 | L 1-5 | 15-6 | 1 | 14,612 | Jack Billingham | John Henry Johnson | John Henry Johnson | Jack Billingham | | 115 | 85 | 30 |
| 1978-05-06 | @ OAK | 22 | W 6-0 | 16-6 | 1 | 12,539 | Bob Sykes | Alan Wirth | Bob Sykes | Alan Wirth | | 121 | 85 | 36 |
| 1978-05-07 | @ OAK | 23 | W 4-0 | 17-6 | 1 | 16,239 | Milt Wilcox | Matt Keough | Milt Wilcox | Matt Keough | | 125 | 85 | 40 |
| 1978-05-09 | vs CAL | 24 | L 5-7 | 17-7 | 1 | 21,089 | Jim Slaton | Frank Tanana | Dave LaRoche | Steve Foucault | | 130 | 92 | 38 |
| 1978-05-12 | vs OAK | 25 | L 4-10 | 17-8 | 1 | 18,367 | Jack Billingham | John Henry Johnson | Elias Sosa | John Hiller | | 134 | 102 | 32 |
| 1978-05-13 | vs OAK | 26 | L 2-3 | 17-9 | 2 | 16,324 | Dave Rozema | Matt Keough | Bob Lacey | Dave Rozema | Elias Sosa | 136 | 105 | 31 |
| 1978-05-14 | vs OAK | 27 | W 15-0 | 18-9 | 2 | 12,513 | Bob Sykes | Pete Broberg | Bob Sykes | Pete Broberg | | 151 | 105 | 46 |
| 1978-05-15 | vs SEA | 28 | W 4-2 | 19-9 | 1 | 8,412 | Jim Slaton | Glenn Abbott | Jim Slaton | Glenn Abbott | | 155 | 107 | 48 |
| 1978-05-16 | vs SEA | 29 | W 4-2 | 20-9 | 1 | 12,423 | Milt Wilcox | Rick Honeycutt | Steve Foucault | Shane Rawley | | 159 | 109 | 50 |
| 1978-05-17 | @ MIL | 30 | W 5-3 | 21-9 | 1 | 10,004 | Jack Billingham | Jerry Augustine | Jack Billingham | Jerry Augustine | John Hiller | 164 | 112 | 52 |
| 1978-05-18 | @ MIL | 31 | L 7-8 | 21-10 | 1 | 15,217 | Jack Morris | Andy Replogle | Bill Castro | Steve Foucault | | 171 | 120 | 51 |
| 1978-05-19 | vs BOS | 32 | W 7-5 | 22-10 | 1 | 48,817 | Bob Sykes | Mike Torrez | Bob Sykes | Mike Torrez | John Hiller | 178 | 125 | 53 |
| 1978-05-20 | vs BOS | 33 | L 5-6 | 22-11 | 1 | 30,856 | Jim Slaton | Dennis Eckersley | Bill Campbell | Steve Foucault | | 183 | 131 | 52 |
| 1978-05-21 | vs BOS | 34 | W 2-1 | 23-12 | 1 | 0 | Milt Wilcox | Bill Lee | Milt Wilcox | Bill Lee | | 185 | 132 | 53 |
| 1978-05-21 | vs BOS | 35 | L 3-9 | 23-12 | 1 | 52,368 | Dave Rozema | Luis Tiant | Luis Tiant | Dave Rozema | | 188 | 141 | 47 |
| 1978-05-23 | @ BAL | 36 | L 0-2 | 23-13 | 1 | 4,536 | Jack Billingham | Mike Flanagan | Mike Flanagan | Jack Billingham | | 188 | 143 | 45 |
| 1978-05-24 | @ BAL | 37 | W 3-2 | 24-14 | 2 | 0 | Jim Slaton | Dennis Martinez | John Hiller | Dennis Martinez | | 191 | 145 | 46 |
| 1978-05-24 | @ BAL | 38 | L 0-1 | 24-14 | 2 | 8,196 | Bob Sykes | Jim Palmer | Jim Palmer | Bob Sykes | | 191 | 146 | 45 |
| 1978-05-25 | @ BAL | 39 | L 1-2 | 24-15 | 3 | 5,109 | Steve Baker | Scott McGregor | Scott McGregor | John Hiller | | 192 | 148 | 44 |
| 1978-05-26 | @ BOS | 40 | L 3-6 | 24-16 | 3 | 33,431 | Milt Wilcox | Bill Lee | Bill Lee | Milt Wilcox | | 195 | 154 | 41 |
| 1978-05-27 | @ BOS | 41 | L 0-1 | 24-17 | 3 | 33,335 | Dave Rozema | Luis Tiant | Luis Tiant | Jack Morris | | 195 | 155 | 40 |
| 1978-05-28 | @ BOS | 42 | L 3-4 | 24-19 | 3 | 0 | Jack Billingham | Allen Ripley | Bob Stanley | John Hiller | | 198 | 159 | 39 |
| 1978-05-28 | @ BOS | 43 | L 3-4 | 24-19 | 3 | 34,672 | Jim Slaton | Jim Wright | Jim Wright | Jim Slaton | Dick Drago | 201 | 163 | 38 |
| 1978-05-29 | vs BAL | 44 | L 3-6 | 24-20 | 3 | 20,534 | Bob Sykes | Scott McGregor | Scott McGregor | Bob Sykes | | 204 | 169 | 35 |
| 1978-05-30 | vs BAL | 45 | W 5-2 | 25-20 | 3 | 10,530 | Steve Baker | Nelson Briles | Steve Baker | Nelson Briles | John Hiller | 209 | 171 | 38 |
| 1978-05-31 | vs MIL | 46 | W 3-0 | 26-20 | 3 | 13,017 | Milt Wilcox | Bill Travers | Milt Wilcox | Bill Travers | | 212 | 171 | 41 |
| 1978-06-01 | vs MIL | 47 | W 4-3 | 27-20 | 3 | 11,614 | Jim Slaton | Lary Sorensen | Jim Slaton | Lary Sorensen | John Hiller | 216 | 174 | 42 |
| 1978-06-02 | vs MIN | 48 | L 2-4 | 27-21 | 3 | 21,127 | Jack Billingham | Roger Erickson | Roger Erickson | Jack Billingham | Mike Marshall | 218 | 178 | 40 |
| 1978-06-03 | vs MIN | 49 | L 2-9 | 27-22 | 3 | 21,227 | Bob Sykes | Dave Goltz | Dave Goltz | Bob Sykes | | 220 | 187 | 33 |
| 1978-06-04 | vs MIN | 50 | W 6-4 | 28-22 | 3 | 36,575 | Steve Baker | Geoff Zahn | Jack Morris | Geoff Zahn | | 226 | 191 | 35 |
| 1978-06-06 | @ MIL | 51 | L 1-5 | 28-23 | 3 | 13,022 | Milt Wilcox | Lary Sorensen | Lary Sorensen | Milt Wilcox | | 227 | 196 | 31 |
| 1978-06-07 | @ MIL | 52 | W 8-1 | 29-23 | 3 | 7,437 | Jim Slaton | Andy Replogle | Jim Slaton | Andy Replogle | | 235 | 197 | 38 |
| 1978-06-09 | vs KCA | 53 | W 3-2 | 30-23 | 3 | 32,309 | Jack Billingham | Paul Splittorff | Jack Billingham | Paul Splittorff | John Hiller | 238 | 199 | 39 |
| 1978-06-10 | vs KCA | 54 | L 3-6 | 30-24 | 3 | 32,381 | Bob Sykes | Dennis Leonard | Dennis Leonard | Jack Morris | | 241 | 205 | 36 |
| 1978-06-11 | vs KCA | 55 | W 5-2 | 31-24 | 3 | 24,210 | Steve Baker | Larry Gura | John Hiller | Al Hrabosky | | 246 | 207 | 39 |
| 1978-06-12 | vs MIL | 56 | L 4-7 | 31-25 | 4 | 14,472 | Milt Wilcox | Eduardo Rodriguez | Bob McClure | Milt Wilcox | | 250 | 214 | 36 |
| 1978-06-13 | vs MIL | 57 | L 2-7 | 31-26 | 5 | 16,622 | Jim Slaton | Mike Caldwell | Mike Caldwell | Jim Slaton | | 252 | 221 | 31 |
| 1978-06-14 | @ KCA | 58 | L 1-7 | 31-27 | 5 | 21,025 | Jack Billingham | Paul Splittorff | Paul Splittorff | Jack Billingham | | 253 | 228 | 25 |
| 1978-06-15 | @ KCA | 59 | L 2-7 | 31-28 | 5 | 19,721 | Bob Sykes | Dennis Leonard | Dennis Leonard | Bob Sykes | | 255 | 235 | 20 |
| 1978-06-16 | @ MIN | 60 | L 2-5 | 31-29 | 5 | 9,479 | Dave Rozema | Darrell Jackson | Darrell Jackson | Dave Rozema | | 257 | 240 | 17 |
| 1978-06-17 | @ MIN | 61 | L 1-3 | 31-30 | 5 | 9,807 | Milt Wilcox | Geoff Zahn | Geoff Zahn | Milt Wilcox | | 258 | 243 | 15 |
| 1978-06-18 | @ MIN | 62 | L 4-8 | 31-31 | 5 | 21,480 | Jim Slaton | Dave Goltz | Dave Goltz | Jim Slaton | Mike Marshall | 262 | 251 | 11 |
| 1978-06-20 | @ TOR | 63 | W 4-3 | 32-31 | 5 | 31,625 | Steve Baker | Jerry Garvin | John Hiller | Mike Willis | | 266 | 254 | 12 |
| 1978-06-21 | @ TOR | 64 | W 10-8 | 33-31 | 5 | 29,439 | Jack Billingham | Tom Underwood | Jim Crawford | Don Kirkwood | Steve Foucault | 276 | 262 | 14 |
| 1978-06-22 | vs NYA | 65 | L 2-4 | 33-32 | 5 | 33,971 | Dave Rozema | Ron Guidry | Ron Guidry | Dave Rozema | Rich Gossage | 278 | 266 | 12 |
| 1978-06-23 | vs NYA | 66 | L 3-12 | 33-33 | 5 | 39,022 | Milt Wilcox | Ed Figueroa | Sparky Lyle | Milt Wilcox | | 281 | 278 | 3 |
| 1978-06-24 | vs NYA | 67 | W 4-3 | 34-33 | 5 | 37,681 | Jim Slaton | Ken Clay | Jim Slaton | Dick Tidrow | | 285 | 281 | 4 |
| 1978-06-25 | vs NYA | 68 | L 2-4 | 34-34 | 5 | 34,014 | Steve Baker | Don Gullett | Don Gullett | Steve Baker | Rich Gossage | 287 | 285 | 2 |
| 1978-06-26 | @ CLE | 69 | L 4-5 | 34-35 | 5 | 4,633 | Jack Billingham | Don Hood | Don Hood | Jack Billingham | Dan Spillner | 291 | 290 | 1 |
| 1978-06-27 | @ CLE | 70 | W 6-1 | 35-35 | 5 | 12,214 | Dave Rozema | Dave Freisleben | Dave Rozema | Dave Freisleben | | 297 | 291 | 6 |
| 1978-06-28 | @ CLE | 71 | W 4-3 | 36-36 | 5 | 0 | Jim Slaton | Rick Waits | Jim Slaton | Rick Waits | John Hiller | 301 | 294 | 7 |
| 1978-06-28 | @ CLE | 72 | L 1-2 | 36-36 | 5 | 13,489 | Milt Wilcox | Mike Paxton | Mike Paxton | Milt Wilcox | Sid Monge | 302 | 296 | 6 |
| 1978-06-29 | @ CLE | 73 | L 3-6 | 36-37 | 5 | 5,672 | Bob Sykes | David Clyde | Jim Kern | Jack Morris | | 305 | 302 | 3 |
| 1978-06-30 | @ NYA | 74 | L 2-10 | 36-38 | 5 | 33,894 | Steve Baker | Don Gullett | Don Gullett | Steve Baker | | 307 | 312 | -5 |
| 1978-07-01 | @ NYA | 75 | W 8-4 | 37-38 | 5 | 37,260 | Jack Billingham | Andy Messersmith | Jack Billingham | Andy Messersmith | | 315 | 316 | -1 |
| 1978-07-02 | @ NYA | 76 | L 2-3 | 37-40 | 5 | 0 | Dave Rozema | Ron Guidry | Ron Guidry | John Hiller | Rich Gossage | 317 | 319 | -2 |
| 1978-07-02 | @ NYA | 77 | L 3-5 | 37-40 | 5 | 51,327 | Jim Slaton | Dave Rajsich | Rich Gossage | Jim Slaton | | 320 | 324 | -4 |
| 1978-07-03 | vs TOR | 78 | W 6-5 | 38-40 | 5 | 21,597 | Milt Wilcox | Jim Clancy | Milt Wilcox | Tom Murphy | | 326 | 329 | -3 |
| 1978-07-04 | vs TOR | 79 | L 2-9 | 38-41 | 5 | 11,913 | Jack Morris | Balor Moore | Balor Moore | Jack Morris | | 328 | 338 | -10 |
| 1978-07-05 | vs CLE | 80 | W 13-3 | 39-41 | 5 | 12,778 | Jack Billingham | Rick Wise | Jack Billingham | Rick Wise | | 341 | 341 | 0 |
| 1978-07-06 | vs CLE | 81 | W 8-4 | 40-41 | 5 | 17,125 | Jim Slaton | Rick Waits | Bob Sykes | Rick Waits | John Hiller | 349 | 345 | 4 |
| 1978-07-07 | @ TEX | 82 | W 12-7 | 41-41 | 5 | 21,069 | Dave Rozema | Dock Ellis | Dave Rozema | Dock Ellis | | 361 | 352 | 9 |
| 1978-07-08 | @ TEX | 83 | W 5-1 | 42-41 | 5 | 22,993 | Milt Wilcox | Doyle Alexander | Milt Wilcox | Doyle Alexander | | 366 | 353 | 13 |
| 1978-07-09 | @ TEX | 84 | L 3-4 | 42-42 | 5 | 15,770 | Steve Baker | Fergie Jenkins | Jim Umbarger | Jim Slaton | | 369 | 357 | 12 |
| 1978-07-13 | @ SEA | 85 | L 4-5 | 42-43 | 5 | 7,449 | Dave Rozema | Glenn Abbott | Enrique Romo | Jim Crawford | | 373 | 362 | 11 |
| 1978-07-14 | @ SEA | 86 | W 2-0 | 43-43 | 5 | 9,742 | Jim Slaton | Rick Honeycutt | Jim Slaton | Shane Rawley | | 375 | 362 | 13 |
| 1978-07-15 | @ CAL | 87 | L 0-2 | 43-44 | 5 | 33,001 | Milt Wilcox | Frank Tanana | Frank Tanana | Milt Wilcox | | 375 | 364 | 11 |
| 1978-07-16 | @ CAL | 88 | W 4-0 | 44-44 | 5 | 21,447 | Jack Billingham | Dave Frost | Jack Billingham | Dave Frost | | 379 | 364 | 15 |
| 1978-07-17 | @ CAL | 89 | W 4-3 | 45-44 | 5 | 32,469 | Steve Baker | John Caneira | Jack Morris | Dave LaRoche | | 383 | 367 | 16 |
| 1978-07-18 | @ OAK | 90 | L 3-6 | 45-45 | 5 | 3,023 | Dave Rozema | Rick Langford | Rick Langford | Dave Rozema | Bob Lacey | 386 | 373 | 13 |
| 1978-07-19 | @ OAK | 91 | W 5-4 | 46-45 | 5 | 5,225 | Jim Slaton | Matt Keough | Jim Slaton | Matt Keough | | 391 | 377 | 14 |
| 1978-07-21 | vs CAL | 92 | L 2-4 | 47-46 | 5 | 0 | Milt Wilcox | Frank Tanana | Dave LaRoche | Kip Young | | 393 | 381 | 12 |
| 1978-07-21 | vs CAL | 93 | W 5-0 | 47-46 | 5 | 33,699 | Jack Billingham | Dave Frost | Jack Billingham | Dave Frost | | 398 | 381 | 17 |
| 1978-07-22 | vs CAL | 94 | W 7-3 | 48-46 | 5 | 31,107 | Jack Morris | John Caneira | Bob Sykes | Ken Brett | | 405 | 384 | 21 |
| 1978-07-23 | vs CAL | 95 | W 4-3 | 49-47 | 5 | 0 | Dave Rozema | Don Aase | Steve Foucault | Dave LaRoche | | 409 | 387 | 22 |
| 1978-07-23 | vs CAL | 96 | L 3-4 | 49-47 | 5 | 35,224 | Jim Slaton | Nolan Ryan | Nolan Ryan | Jim Slaton | | 412 | 391 | 21 |
| 1978-07-24 | vs OAK | 97 | W 4-1 | 50-47 | 5 | 19,733 | Kip Young | Matt Keough | Kip Young | Matt Keough | | 416 | 392 | 24 |
| 1978-07-25 | vs OAK | 98 | W 11-2 | 51-47 | 5 | 17,723 | Milt Wilcox | Steve Renko | Milt Wilcox | Steve Renko | | 427 | 394 | 33 |
| 1978-07-26 | vs BAL | 99 | W 9-6 | 52-47 | 5 | 18,056 | Jack Billingham | Mike Flanagan | Jack Billingham | Mike Flanagan | Bob Sykes | 436 | 400 | 36 |
| 1978-07-27 | vs BAL | 100 | L 3-7 | 52-48 | 5 | 22,856 | Jim Slaton | Scott McGregor | Scott McGregor | Jim Slaton | | 439 | 407 | 32 |
| 1978-07-28 | vs SEA | 101 | W 4-3 | 53-48 | 5 | 20,484 | Dave Rozema | Jim Colborn | Dave Rozema | Enrique Romo | | 443 | 410 | 33 |
| 1978-07-29 | vs SEA | 102 | W 9-1 | 54-48 | 5 | 22,984 | Kip Young | Rick Honeycutt | Kip Young | Rick Honeycutt | | 452 | 411 | 41 |
| 1978-07-30 | vs SEA | 103 | W 5-4 | 55-48 | 5 | 21,575 | Milt Wilcox | Glenn Abbott | Milt Wilcox | Glenn Abbott | Bob Sykes | 457 | 415 | 42 |
| 1978-07-31 | @ TOR | 104 | L 7-8 | 55-49 | 5 | 18,032 | Jack Billingham | Balor Moore | Joe Coleman | Bob Sykes | | 464 | 423 | 41 |
| 1978-08-01 | @ TOR | 105 | W 3-2 | 56-49 | 5 | 19,265 | Jim Slaton | Jim Clancy | Jim Slaton | Jim Clancy | | 467 | 425 | 42 |
| 1978-08-03 | vs CHA | 106 | W 5-4 | 57-49 | 5 | 11,257 | Dave Rozema | Steve Stone | Bob Sykes | Lerrin LaGrow | | 472 | 429 | 43 |
| 1978-08-04 | vs CHA | 107 | W 7-1 | 58-49 | 5 | 31,334 | Kip Young | Wilbur Wood | Kip Young | Wilbur Wood | | 479 | 430 | 49 |
| 1978-08-05 | vs CHA | 108 | W 7-0 | 59-49 | 5 | 33,494 | Jack Billingham | Britt Burns | Jack Billingham | Britt Burns | | 486 | 430 | 56 |
| 1978-08-06 | vs CHA | 109 | W 8-0 | 60-49 | 5 | 27,504 | Jim Slaton | Ken Kravec | Jim Slaton | Ken Kravec | | 494 | 430 | 64 |
| 1978-08-08 | vs TEX | 110 | L 4-9 | 60-50 | 4 | 20,951 | Dave Rozema | Paul Mirabella | Paul Mirabella | Dave Rozema | Doc Medich | 498 | 439 | 59 |
| 1978-08-09 | vs TEX | 111 | W 5-2 | 61-50 | 4 | 30,167 | Kip Young | Fergie Jenkins | Kip Young | Jim Umbarger | | 503 | 441 | 62 |
| 1978-08-11 | @ CHA | 112 | W 7-3 | 62-50 | 4 | 25,798 | Jack Billingham | Britt Burns | Jack Billingham | Britt Burns | | 510 | 444 | 66 |
| 1978-08-12 | @ CHA | 113 | L 3-6 | 62-51 | 3 | 20,128 | Jim Slaton | Ken Kravec | Ken Kravec | Jim Slaton | Lerrin LaGrow | 513 | 450 | 63 |
| 1978-08-13 | @ CHA | 114 | W 10-2 | 63-51 | 3 | 33,128 | Dave Rozema | Mike Proly | Dave Rozema | Mike Proly | | 523 | 452 | 71 |
| 1978-08-14 | vs KCA | 115 | W 11-2 | 64-51 | 3 | 31,409 | Milt Wilcox | Rich Gale | Milt Wilcox | Rich Gale | | 534 | 454 | 80 |
| 1978-08-15 | vs KCA | 116 | L 2-4 | 64-52 | 3 | 33,365 | Kip Young | Dennis Leonard | Dennis Leonard | Kip Young | Al Hrabosky | 536 | 458 | 78 |
| 1978-08-16 | vs CLE | 117 | W 2-0 | 65-52 | 4 | 15,819 | Jack Billingham | David Clyde | Jack Billingham | David Clyde | | 538 | 458 | 80 |
| 1978-08-17 | vs CLE | 118 | W 9-5 | 66-52 | 4 | 18,966 | Jim Slaton | Dave Freisleben | Jack Morris | Don Hood | | 547 | 463 | 84 |
| 1978-08-18 | @ MIL | 119 | L 0-2 | 66-53 | 4 | 27,543 | Dave Rozema | Lary Sorensen | Lary Sorensen | Dave Rozema | | 547 | 465 | 82 |
| 1978-08-19 | @ MIL | 120 | W 6-4 | 67-53 | 4 | 35,104 | Milt Wilcox | Jerry Augustine | Milt Wilcox | Jerry Augustine | | 553 | 469 | 84 |
| 1978-08-20 | @ MIL | 121 | L 1-2 | 67-54 | 4 | 46,791 | Kip Young | Mike Caldwell | Mike Caldwell | Kip Young | | 554 | 471 | 83 |
| 1978-08-21 | @ MIN | 122 | W 9-6 | 68-54 | 4 | 7,419 | Jack Billingham | Geoff Zahn | Jack Billingham | Geoff Zahn | | 563 | 477 | 86 |
| 1978-08-22 | @ MIN | 123 | W 7-3 | 69-54 | 4 | 7,726 | Jim Slaton | Darrell Jackson | Jim Slaton | Stan Perzanowski | | 570 | 480 | 90 |
| 1978-08-23 | vs TOR | 124 | L 3-4 | 69-56 | 4 | 0 | Dave Rozema | Tom Underwood | Victor Cruz | Dave Rozema | | 573 | 484 | 89 |
| 1978-08-23 | vs TOR | 125 | L 4-5 | 69-56 | 4 | 26,631 | Bob Sykes | Jerry Garvin | Jerry Garvin | Bob Sykes | Mike Willis | 577 | 489 | 88 |
| 1978-08-24 | vs TOR | 126 | W 5-2 | 70-56 | 4 | 13,314 | Milt Wilcox | Balor Moore | Milt Wilcox | Balor Moore | | 582 | 491 | 91 |
| 1978-08-25 | vs MIL | 127 | W 6-3 | 71-56 | 4 | 32,010 | Kip Young | Mike Caldwell | Kip Young | Mike Caldwell | John Hiller | 588 | 494 | 94 |
| 1978-08-26 | vs MIL | 128 | L 5-9 | 71-57 | 4 | 32,103 | Jack Billingham | Bill Travers | Bill Travers | Jack Billingham | Bob McClure | 593 | 503 | 90 |
| 1978-08-27 | vs MIL | 129 | W 4-2 | 72-57 | 4 | 43,478 | Jim Slaton | Lary Sorensen | Jim Slaton | Lary Sorensen | John Hiller | 597 | 505 | 92 |
| 1978-08-28 | vs MIL | 130 | L 1-10 | 72-58 | 4 | 23,037 | Dave Rozema | Jerry Augustine | Jerry Augustine | Dave Rozema | | 598 | 515 | 83 |
| 1978-08-29 | vs MIN | 131 | W 4-2 | 73-58 | 4 | 13,839 | Milt Wilcox | Dave Goltz | Milt Wilcox | Dave Goltz | | 602 | 517 | 85 |
| 1978-08-31 | vs MIN | 132 | L 1-4 | 73-59 | 4 | 16,995 | Kip Young | Geoff Zahn | Geoff Zahn | Kip Young | Mike Marshall | 603 | 521 | 82 |
| 1978-09-01 | @ KCA | 133 | W 6-2 | 74-59 | 4 | 32,329 | Jack Billingham | Dennis Leonard | Jack Billingham | Dennis Leonard | | 609 | 523 | 86 |
| 1978-09-02 | @ KCA | 134 | L 3-8 | 74-60 | 5 | 34,004 | Jim Slaton | Paul Splittorff | Paul Splittorff | Jim Slaton | | 612 | 531 | 81 |
| 1978-09-03 | @ KCA | 135 | L 2-6 | 74-61 | 5 | 27,217 | Dave Rozema | Larry Gura | Larry Gura | Dave Rozema | | 614 | 537 | 77 |
| 1978-09-04 | @ NYA | 136 | L 1-9 | 75-62 | 5 | 0 | Milt Wilcox | Ron Guidry | Ron Guidry | Milt Wilcox | | 615 | 546 | 69 |
| 1978-09-04 | @ NYA | 137 | W 5-4 | 75-62 | 5 | 46,896 | Jack Morris | Paul Lindblad | John Hiller | Sparky Lyle | | 620 | 550 | 70 |
| 1978-09-05 | @ NYA | 138 | L 2-4 | 75-63 | 5 | 16,891 | Kip Young | Dick Tidrow | Dick Tidrow | Kip Young | Rich Gossage | 622 | 554 | 68 |
| 1978-09-06 | @ NYA | 139 | L 2-8 | 75-64 | 5 | 24,452 | Jack Billingham | Ed Figueroa | Ed Figueroa | Jack Billingham | | 624 | 562 | 62 |
| 1978-09-08 | vs CLE | 140 | W 6-3 | 76-64 | 5 | 13,624 | Jim Slaton | David Clyde | Jim Slaton | David Clyde | John Hiller | 630 | 565 | 65 |
| 1978-09-09 | vs CLE | 141 | W 5-2 | 77-64 | 5 | 16,026 | Dave Rozema | Mike Paxton | Dave Rozema | Mike Paxton | | 635 | 567 | 68 |
| 1978-09-10 | vs CLE | 142 | L 4-7 | 77-65 | 5 | 15,583 | Milt Wilcox | Paul Reuschel | Jim Kern | Milt Wilcox | | 639 | 574 | 65 |
| 1978-09-12 | vs NYA | 143 | W 7-4 | 78-65 | 5 | 14,162 | Kip Young | Dick Tidrow | Kip Young | Dick Tidrow | John Hiller | 646 | 578 | 68 |
| 1978-09-13 | vs NYA | 144 | L 3-7 | 78-66 | 5 | 16,841 | Jack Billingham | Jim Beattie | Jim Beattie | Jack Billingham | | 649 | 585 | 64 |
| 1978-09-14 | vs NYA | 145 | L 2-4 | 78-67 | 5 | 17,118 | Jim Slaton | Ed Figueroa | Ed Figueroa | Jim Slaton | Sparky Lyle | 651 | 589 | 62 |
| 1978-09-15 | @ CLE | 146 | W 1-0 | 79-67 | 5 | 4,070 | Dave Rozema | Paul Reuschel | Dave Rozema | Paul Reuschel | | 652 | 589 | 63 |
| 1978-09-16 | @ CLE | 147 | W 10-4 | 80-67 | 5 | 4,640 | Milt Wilcox | Rick Waits | Milt Wilcox | Rick Waits | | 662 | 593 | 69 |
| 1978-09-17 | @ CLE | 148 | L 1-2 | 80-68 | 5 | 4,515 | Kip Young | Don Hood | Jim Kern | Kip Young | | 663 | 595 | 68 |
| 1978-09-18 | vs BOS | 149 | L 4-5 | 80-69 | 5 | 13,849 | Jack Billingham | Bobby Sprowl | Andy Hassler | Steve Baker | | 667 | 600 | 67 |
| 1978-09-19 | vs BOS | 150 | L 6-8 | 80-70 | 5 | 15,901 | Jim Slaton | Luis Tiant | Bill Campbell | Jack Morris | Andy Hassler | 673 | 608 | 65 |
| 1978-09-20 | vs BOS | 151 | W 12-2 | 81-70 | 5 | 16,689 | Dave Rozema | Mike Torrez | Dave Rozema | Mike Torrez | | 685 | 610 | 75 |
| 1978-09-21 | vs BOS | 152 | L 1-5 | 81-71 | 5 | 15,213 | Milt Wilcox | Dennis Eckersley | Dennis Eckersley | Milt Wilcox | | 686 | 615 | 71 |
| 1978-09-22 | @ BAL | 153 | W 7-5 | 82-71 | 5 | 5,444 | Kip Young | Mike Flanagan | John Hiller | Mike Flanagan | | 693 | 620 | 73 |
| 1978-09-23 | @ BAL | 154 | W 4-3 | 83-72 | 5 | 0 | Jack Billingham | Dennis Martinez | John Hiller | Don Stanhouse | | 697 | 623 | 74 |
| 1978-09-23 | @ BAL | 155 | L 1-6 | 83-72 | 5 | 13,036 | Steve Baker | Jim Palmer | Jim Palmer | Steve Baker | | 698 | 629 | 69 |
| 1978-09-24 | @ BAL | 156 | W 4-2 | 84-72 | 5 | 9,081 | Jim Slaton | Scott McGregor | Jim Slaton | Don Stanhouse | | 702 | 631 | 71 |
| 1978-09-26 | @ BOS | 157 | L 0-6 | 84-73 | 5 | 27,078 | Dave Rozema | Dennis Eckersley | Dennis Eckersley | Dave Rozema | | 702 | 637 | 65 |
| 1978-09-27 | @ BOS | 158 | L 2-5 | 84-74 | 5 | 26,035 | Milt Wilcox | Luis Tiant | Luis Tiant | Milt Wilcox | Bob Stanley | 704 | 642 | 62 |
| 1978-09-28 | @ BOS | 159 | L 0-1 | 84-75 | 5 | 26,774 | Kip Young | Mike Torrez | Mike Torrez | Kip Young | | 704 | 643 | 61 |
| 1978-09-29 | vs BAL | 160 | W 3-2 | 85-75 | 5 | 12,348 | Jim Slaton | Sammy Stewart | Jim Slaton | Sammy Stewart | John Hiller | 707 | 645 | 62 |
| 1978-09-30 | vs BAL | 161 | W 5-4 | 86-75 | 5 | 13,919 | Jack Morris | Mike Flanagan | Steve Baker | Mike Flanagan | John Hiller | 712 | 649 | 63 |
| 1978-10-01 | vs BAL | 162 | L 2-4 | 86-76 | 5 | 13,948 | Dave Rozema | Dennis Martinez | Dennis Martinez | Dave Rozema | | 714 | 653 | 61 |