| 1977-04-07 | @ BOS | 1 | W 5-4 | 1-0 | 1 | 34,790 | Dennis Eckersley | Fergie Jenkins | Dave LaRoche | Bill Campbell | | 5 | 4 | 1 |
| 1977-04-10 | @ BOS | 2 | W 19-9 | 2-0 | 1 | 14,931 | Al Fitzmorris | Reggie Cleveland | Dave LaRoche | Bill Campbell | | 24 | 13 | 11 |
| 1977-04-11 | @ TEX | 3 | L 2-3 | 2-1 | 2 | 25,208 | Pat Dobson | Bert Blyleven | Adrian Devine | Dave LaRoche | | 26 | 16 | 10 |
| 1977-04-13 | @ TEX | 4 | W 5-3 | 3-1 | 1 | 12,260 | Dennis Eckersley | Tommy Boggs | Dennis Eckersley | Tommy Boggs | | 31 | 19 | 12 |
| 1977-04-16 | vs BOS | 5 | L 4-8 | 3-2 | 2 | 51,165 | Wayne Garland | Luis Tiant | Luis Tiant | Wayne Garland | Bob Stanley | 35 | 27 | 8 |
| 1977-04-17 | vs BOS | 6 | L 1-4 | 4-3 | 2 | 0 | Al Fitzmorris | Reggie Cleveland | Reggie Cleveland | Al Fitzmorris | | 36 | 31 | 5 |
| 1977-04-17 | vs BOS | 7 | W 10-5 | 4-3 | 2 | 15,439 | Jim Bibby | Rick Wise | Jim Bibby | Tom Murphy | Dave LaRoche | 46 | 36 | 10 |
| 1977-04-18 | @ BAL | 8 | L 3-4 | 4-4 | 4 | 6,466 | Pat Dobson | Rudy May | Rudy May | Pat Dobson | Dyar Miller | 49 | 40 | 9 |
| 1977-04-19 | @ BAL | 9 | L 5-6 | 4-5 | 5 | 4,826 | Dennis Eckersley | Mike Flanagan | Dyar Miller | Dave LaRoche | | 54 | 46 | 8 |
| 1977-04-20 | @ BAL | 10 | L 2-7 | 4-6 | 5 | 6,439 | Wayne Garland | Scott McGregor | Scott McGregor | Wayne Garland | | 56 | 53 | 3 |
| 1977-04-23 | vs NYA | 11 | L 3-9 | 4-7 | 6 | 16,334 | Al Fitzmorris | Dock Ellis | Dock Ellis | Al Fitzmorris | Dick Tidrow | 59 | 62 | -3 |
| 1977-04-24 | vs NYA | 12 | L 1-10 | 4-9 | 7 | 0 | Dennis Eckersley | Gil Patterson | Dick Tidrow | Dennis Eckersley | Ron Guidry | 60 | 72 | -12 |
| 1977-04-24 | vs NYA | 13 | L 1-7 | 4-9 | 7 | 29,260 | Pat Dobson | Ed Figueroa | Ed Figueroa | Pat Dobson | | 61 | 79 | -18 |
| 1977-04-27 | vs TOR | 14 | L 5-6 | 4-10 | 7 | 3,639 | Wayne Garland | Steve Hargan | Mike Willis | Jim Kern | | 66 | 85 | -19 |
| 1977-04-28 | vs TOR | 15 | W 4-3 | 5-10 | 7 | 2,724 | Al Fitzmorris | Jesse Jefferson | Al Fitzmorris | Jesse Jefferson | Rick Waits | 70 | 88 | -18 |
| 1977-04-29 | @ MIL | 16 | L 5-6 | 5-11 | 7 | 10,511 | Pat Dobson | Bill Travers | Bill Travers | Pat Dobson | Bob McClure | 75 | 94 | -19 |
| 1977-04-30 | @ MIL | 17 | W 1-0 | 6-11 | 7 | 12,324 | Dennis Eckersley | Jim Slaton | Dennis Eckersley | Jim Slaton | Dave LaRoche | 76 | 94 | -18 |
| 1977-05-01 | @ MIL | 18 | L 3-7 | 7-12 | 7 | 26,336 | Wayne Garland | Jerry Augustine | Jerry Augustine | Wayne Garland | | 79 | 101 | -22 |
| 1977-05-01 | @ MIL | 19 | W 8-5 | 7-12 | 7 | 26,336 | Jim Bibby | Gary Beare | Al Fitzmorris | Gary Beare | Jim Kern | 87 | 106 | -19 |
| 1977-05-03 | vs MIN | 20 | L 3-4 | 7-13 | 7 | 4,363 | Al Fitzmorris | Dave Goltz | Tom Burgmeier | Jim Kern | Tom Johnson | 90 | 110 | -20 |
| 1977-05-04 | vs MIN | 21 | W 6-5 | 8-13 | 6 | 3,353 | Pat Dobson | Pete Redfern | Don Hood | Tom Johnson | Dave LaRoche | 96 | 115 | -19 |
| 1977-05-06 | vs CHA | 22 | L 5-7 | 8-14 | 7 | 7,825 | Dennis Eckersley | Francisco Barrios | Francisco Barrios | Dennis Eckersley | Dave Hamilton | 101 | 122 | -21 |
| 1977-05-07 | vs CHA | 23 | L 2-5 | 8-15 | 7 | 15,026 | Wayne Garland | Chris Knapp | Bart Johnson | Wayne Garland | | 103 | 127 | -24 |
| 1977-05-08 | vs CHA | 24 | L 3-8 | 8-16 | 7 | 13,145 | Al Fitzmorris | Steve Stone | Steve Stone | Al Fitzmorris | | 106 | 135 | -29 |
| 1977-05-10 | vs MIL | 25 | W 1-0 | 10-16 | 6 | 0 | Jim Bibby | Jim Slaton | Jim Bibby | Jim Slaton | | 107 | 135 | -28 |
| 1977-05-10 | vs MIL | 26 | W 7-4 | 10-16 | 6 | 4,259 | Dennis Eckersley | Gary Beare | Jim Kern | Gary Beare | Dave LaRoche | 114 | 139 | -25 |
| 1977-05-11 | vs MIL | 27 | W 4-3 | 11-16 | 6 | 3,541 | Wayne Garland | Jerry Augustine | Wayne Garland | Jerry Augustine | Jim Kern | 118 | 142 | -24 |
| 1977-05-13 | @ CHA | 28 | L 3-5 | 11-17 | 7 | 27,130 | Al Fitzmorris | Steve Stone | Steve Stone | Al Fitzmorris | Lerrin LaGrow | 121 | 147 | -26 |
| 1977-05-14 | @ CHA | 29 | L 2-18 | 11-18 | 7 | 13,923 | Jim Bibby | Ken Brett | Ken Brett | Jim Bibby | | 123 | 165 | -42 |
| 1977-05-15 | @ CHA | 30 | W 4-3 | 12-18 | 7 | 16,046 | Dennis Eckersley | Francisco Barrios | Dennis Eckersley | Francisco Barrios | Jim Kern | 127 | 168 | -41 |
| 1977-05-16 | @ MIN | 31 | L 1-8 | 12-19 | 7 | 5,451 | Wayne Garland | Geoff Zahn | Geoff Zahn | Wayne Garland | | 128 | 176 | -48 |
| 1977-05-17 | @ MIN | 32 | L 4-10 | 12-20 | 7 | 7,831 | Pat Dobson | Jeff Holly | Tom Burgmeier | Pat Dobson | | 132 | 186 | -54 |
| 1977-05-20 | @ KCA | 33 | L 0-4 | 12-21 | 7 | 17,532 | Dennis Eckersley | Paul Splittorff | Paul Splittorff | Dennis Eckersley | | 132 | 190 | -58 |
| 1977-05-21 | @ KCA | 34 | W 12-7 | 13-21 | 7 | 20,114 | Wayne Garland | Doug Bird | Rick Waits | Mark Littell | | 144 | 197 | -53 |
| 1977-05-22 | @ KCA | 35 | W 7-1 | 14-21 | 7 | 31,059 | Jim Bibby | Dennis Leonard | Jim Bibby | Dennis Leonard | | 151 | 198 | -47 |
| 1977-05-24 | vs SEA | 36 | W 7-5 | 15-21 | 6 | 5,576 | Pat Dobson | Dave Pagan | Rick Waits | Enrique Romo | Jim Kern | 158 | 203 | -45 |
| 1977-05-25 | vs SEA | 37 | W 2-1 | 16-21 | 6 | 4,516 | Dennis Eckersley | John Montague | Dennis Eckersley | Bill Laxton | | 160 | 204 | -44 |
| 1977-05-27 | vs OAK | 38 | W 3-1 | 17-21 | 5 | 16,557 | Wayne Garland | Vida Blue | Wayne Garland | Vida Blue | | 163 | 205 | -42 |
| 1977-05-28 | vs OAK | 39 | L 1-5 | 17-22 | 5 | 15,482 | Jim Bibby | Doc Medich | Doc Medich | Jim Bibby | Bob Lacey | 164 | 210 | -46 |
| 1977-05-29 | vs OAK | 40 | W 5-4 | 18-22 | 5 | 25,476 | Pat Dobson | Rick Langford | Sid Monge | Bob Lacey | | 169 | 214 | -45 |
| 1977-05-30 | vs CAL | 41 | W 1-0 | 19-22 | 5 | 13,400 | Dennis Eckersley | Frank Tanana | Dennis Eckersley | Frank Tanana | | 170 | 214 | -44 |
| 1977-05-31 | vs CAL | 42 | L 6-7 | 19-23 | 5 | 5,174 | Wayne Garland | Paul Hartzell | Dave LaRoche | Jim Kern | Dick Drago | 176 | 221 | -45 |
| 1977-06-01 | @ DET | 43 | W 6-4 | 20-23 | 5 | 17,718 | Jim Bibby | Mark Fidrych | Jim Bibby | Mark Fidrych | Sid Monge | 182 | 225 | -43 |
| 1977-06-02 | @ DET | 44 | L 2-4 | 20-24 | 5 | 7,274 | Pat Dobson | Dave Rozema | Dave Rozema | Pat Dobson | Steve Foucault | 184 | 229 | -45 |
| 1977-06-03 | @ SEA | 45 | W 7-1 | 21-24 | 5 | 19,438 | Dennis Eckersley | Rick Jones | Dennis Eckersley | Rick Jones | Jim Kern | 191 | 230 | -39 |
| 1977-06-04 | @ SEA | 46 | W 7-5 | 22-24 | 5 | 24,074 | Wayne Garland | Dave Pagan | Rick Waits | Mike Kekich | Sid Monge | 198 | 235 | -37 |
| 1977-06-05 | @ SEA | 47 | L 1-6 | 22-25 | 5 | 14,167 | Jim Bibby | John Montague | John Montague | Jim Bibby | | 199 | 241 | -42 |
| 1977-06-06 | @ OAK | 48 | W 3-1 | 23-25 | 5 | 13,264 | Pat Dobson | Doc Medich | Pat Dobson | Bob Lacey | Jim Kern | 202 | 242 | -40 |
| 1977-06-08 | @ OAK | 49 | L 2-3 | 23-26 | 5 | 7,828 | Dennis Eckersley | Mike Norris | Pablo Torrealba | Dennis Eckersley | Bob Lacey | 204 | 245 | -41 |
| 1977-06-10 | @ CAL | 50 | L 0-1 | 23-27 | 5 | 20,000 | Wayne Garland | Frank Tanana | Frank Tanana | Wayne Garland | | 204 | 246 | -42 |
| 1977-06-11 | @ CAL | 51 | W 3-1 | 24-27 | 5 | 16,247 | Jim Bibby | Gary Ross | Jim Bibby | Gary Ross | Jim Kern | 207 | 247 | -40 |
| 1977-06-12 | @ CAL | 52 | L 4-11 | 24-28 | 5 | 23,926 | Pat Dobson | Nolan Ryan | Nolan Ryan | Pat Dobson | Dave LaRoche | 211 | 258 | -47 |
| 1977-06-13 | vs TEX | 53 | L 0-3 | 24-29 | 5 | 9,811 | Dennis Eckersley | Bert Blyleven | Bert Blyleven | Dennis Eckersley | | 211 | 261 | -50 |
| 1977-06-14 | vs TEX | 54 | L 2-7 | 24-30 | 6 | 9,248 | Wayne Garland | Gaylord Perry | Gaylord Perry | Wayne Garland | | 213 | 268 | -55 |
| 1977-06-15 | vs TEX | 55 | L 0-6 | 24-31 | 6 | 5,883 | Jim Bibby | Mike Marshall | Mike Marshall | Jim Bibby | | 213 | 274 | -61 |
| 1977-06-17 | vs DET | 56 | W 8-5 | 25-31 | 6 | 21,452 | Rick Waits | Dave Rozema | Jim Kern | Jim Crawford | | 221 | 279 | -58 |
| 1977-06-18 | vs DET | 57 | W 5-4 | 26-31 | 5 | 16,062 | Dennis Eckersley | Dave Roberts | Dennis Eckersley | Steve Foucault | | 226 | 283 | -57 |
| 1977-06-19 | vs DET | 58 | W 4-2 | 28-31 | 4 | 0 | Wayne Garland | John Hiller | Wayne Garland | John Hiller | | 230 | 285 | -55 |
| 1977-06-19 | vs DET | 59 | W 4-0 | 28-31 | 4 | 33,243 | Jim Bibby | Fernando Arroyo | Jim Bibby | Fernando Arroyo | | 234 | 285 | -51 |
| 1977-06-20 | @ TOR | 60 | W 8-5 | 29-31 | 4 | 24,568 | Al Fitzmorris | Jeff Byrd | Pat Dobson | Mike Willis | Jim Kern | 242 | 290 | -48 |
| 1977-06-21 | @ TOR | 61 | W 4-0 | 30-31 | 4 | 18,039 | Rick Waits | Jerry Garvin | Rick Waits | Jerry Garvin | Jim Kern | 246 | 290 | -44 |
| 1977-06-22 | @ TOR | 62 | W 7-5 | 31-31 | 4 | 29,750 | Dennis Eckersley | Pete Vuckovich | Jim Kern | Jerry Johnson | Sid Monge | 253 | 295 | -42 |
| 1977-06-23 | @ TOR | 63 | W 4-0 | 32-31 | 4 | 16,747 | Wayne Garland | Jesse Jefferson | Wayne Garland | Jesse Jefferson | | 257 | 295 | -38 |
| 1977-06-24 | @ DET | 64 | W 4-2 | 33-31 | 3 | 22,533 | Jim Bibby | Fernando Arroyo | Jim Bibby | Fernando Arroyo | | 261 | 297 | -36 |
| 1977-06-25 | @ DET | 65 | L 4-6 | 33-32 | 4 | 37,279 | Pat Dobson | Mark Fidrych | Mark Fidrych | Pat Dobson | | 265 | 303 | -38 |
| 1977-06-26 | @ DET | 66 | W 5-2 | 34-33 | 4 | 0 | Rick Waits | John Hiller | Rick Waits | John Hiller | Jim Kern | 270 | 305 | -35 |
| 1977-06-26 | @ DET | 67 | L 2-3 | 34-33 | 4 | 30,582 | Wayne Garland | Bob Sykes | Bob Sykes | Wayne Garland | | 272 | 308 | -36 |
| 1977-06-27 | vs BAL | 68 | L 2-9 | 34-34 | 4 | 19,320 | Dennis Eckersley | Mike Flanagan | Mike Flanagan | Dennis Eckersley | | 274 | 317 | -43 |
| 1977-06-29 | vs BAL | 69 | W 11-8 | 35-35 | 4 | 23,286 | Jim Bibby | Rudy May | Jim Bibby | Rudy May | Jim Kern | 285 | 325 | -40 |
| 1977-06-29 | vs BAL | 70 | L 3-5 | 35-35 | 4 | 23,286 | Pat Dobson | Dennis Martinez | Dick Drago | Jim Kern | | 288 | 330 | -42 |
| 1977-06-30 | vs BAL | 71 | W 4-2 | 36-35 | 4 | 6,793 | Wayne Garland | Ross Grimsley | Wayne Garland | Ross Grimsley | | 292 | 332 | -40 |
| 1977-07-01 | vs KCA | 72 | L 2-12 | 36-36 | 4 | 16,460 | Rick Waits | Paul Splittorff | Marty Pattin | Rick Waits | | 294 | 344 | -50 |
| 1977-07-02 | vs KCA | 73 | L 0-1 | 36-37 | 4 | 16,227 | Dennis Eckersley | Andy Hassler | Andy Hassler | Dennis Eckersley | | 294 | 345 | -51 |
| 1977-07-03 | vs KCA | 74 | W 6-3 | 37-37 | 4 | 54,690 | Pat Dobson | Dennis Leonard | Pat Dobson | Dennis Leonard | Jim Kern | 300 | 348 | -48 |
| 1977-07-04 | @ NYA | 75 | L 5-7 | 37-38 | 4 | 15,920 | Wayne Garland | Ed Figueroa | Ed Figueroa | Wayne Garland | | 305 | 355 | -50 |
| 1977-07-05 | @ NYA | 76 | L 4-5 | 37-39 | 4 | 16,053 | Jim Bibby | Mike Torrez | Sparky Lyle | Jim Bibby | | 309 | 360 | -51 |
| 1977-07-07 | @ NYA | 77 | L 2-8 | 37-40 | 4 | 21,419 | Rick Waits | Catfish Hunter | Catfish Hunter | Rick Waits | | 311 | 368 | -57 |
| 1977-07-08 | vs TOR | 78 | W 11-5 | 38-40 | 4 | 12,719 | Dennis Eckersley | Dave Lemanczyk | Dennis Eckersley | Dave Lemanczyk | | 322 | 373 | -51 |
| 1977-07-09 | vs TOR | 79 | W 3-2 | 39-40 | 4 | 19,594 | Wayne Garland | Jerry Garvin | Wayne Garland | Jerry Garvin | | 325 | 375 | -50 |
| 1977-07-10 | vs TOR | 80 | L 3-5 | 39-41 | 4 | 12,935 | Pat Dobson | Jeff Byrd | Jeff Byrd | Pat Dobson | Pete Vuckovich | 328 | 380 | -52 |
| 1977-07-11 | vs BOS | 81 | L 1-2 | 39-42 | 4 | 12,573 | Jim Bibby | Bob Stanley | Bob Stanley | Jim Bibby | | 329 | 382 | -53 |
| 1977-07-12 | vs BOS | 82 | W 7-1 | 40-42 | 4 | 14,425 | Dennis Eckersley | Reggie Cleveland | Dennis Eckersley | Reggie Cleveland | | 336 | 383 | -47 |
| 1977-07-13 | vs BOS | 83 | L 7-9 | 40-43 | 4 | 18,524 | Wayne Garland | Fergie Jenkins | Bill Campbell | Jim Kern | Bill Lee | 343 | 392 | -49 |
| 1977-07-14 | vs BOS | 84 | L 4-7 | 40-44 | 4 | 15,451 | Al Fitzmorris | Luis Tiant | Mike Paxton | Al Fitzmorris | Ramon Hernandez | 347 | 399 | -52 |
| 1977-07-15 | @ TEX | 85 | L 3-8 | 40-46 | 4 | 0 | Jim Bibby | Bert Blyleven | Bert Blyleven | Jim Bibby | | 350 | 407 | -57 |
| 1977-07-15 | @ TEX | 86 | L 1-8 | 40-46 | 4 | 15,946 | Pat Dobson | Len Barker | Len Barker | Pat Dobson | Nelson Briles | 351 | 415 | -64 |
| 1977-07-16 | @ TEX | 87 | L 4-5 | 40-47 | 4 | 19,884 | Dennis Eckersley | Doyle Alexander | Doyle Alexander | Jim Kern | Adrian Devine | 355 | 420 | -65 |
| 1977-07-17 | @ TEX | 88 | W 6-1 | 41-47 | 4 | 13,192 | Wayne Garland | Dock Ellis | Wayne Garland | Dock Ellis | | 361 | 421 | -60 |
| 1977-07-21 | @ BOS | 89 | L 4-11 | 42-48 | 4 | 20,173 | Wayne Garland | Luis Tiant | Luis Tiant | Wayne Garland | | 365 | 432 | -67 |
| 1977-07-21 | @ BOS | 90 | W 8-2 | 42-48 | 4 | 29,059 | Jim Bibby | Bob Stanley | Jim Bibby | Bob Stanley | Jim Kern | 373 | 434 | -61 |
| 1977-07-22 | @ BOS | 91 | L 0-3 | 42-49 | 5 | 34,030 | Al Fitzmorris | Rick Wise | Rick Wise | Al Fitzmorris | | 373 | 437 | -64 |
| 1977-07-23 | @ BOS | 92 | W 9-8 | 43-49 | 4 | 35,592 | Dennis Eckersley | Reggie Cleveland | Jim Kern | Bill Campbell | | 382 | 445 | -63 |
| 1977-07-24 | vs TEX | 93 | L 1-4 | 43-50 | 4 | 14,177 | Wayne Garland | Doyle Alexander | Doyle Alexander | Wayne Garland | | 383 | 449 | -66 |
| 1977-07-25 | vs TEX | 94 | L 4-6 | 43-51 | 5 | 10,752 | Jim Bibby | Dock Ellis | Nelson Briles | Jim Kern | Adrian Devine | 387 | 455 | -68 |
| 1977-07-27 | @ KCA | 95 | L 4-5 | 43-52 | 5 | 23,818 | Al Fitzmorris | Dennis Leonard | Doug Bird | Rick Waits | | 391 | 460 | -69 |
| 1977-07-28 | @ KCA | 96 | L 4-5 | 43-53 | 5 | 25,211 | Dennis Eckersley | Jim Colborn | Doug Bird | Dennis Eckersley | | 395 | 465 | -70 |
| 1977-07-29 | vs MIN | 97 | L 1-3 | 43-54 | 6 | 8,576 | Wayne Garland | Paul Thormodsgard | Paul Thormodsgard | Wayne Garland | Tom Johnson | 396 | 468 | -72 |
| 1977-07-30 | vs MIN | 98 | L 3-4 | 43-55 | 6 | 18,051 | Jim Bibby | Ron Schueler | Tom Johnson | Sid Monge | | 399 | 472 | -73 |
| 1977-07-31 | vs MIN | 99 | W 9-2 | 44-56 | 6 | 0 | Al Fitzmorris | Pete Redfern | Al Fitzmorris | Pete Redfern | | 408 | 474 | -66 |
| 1977-07-31 | vs MIN | 100 | L 4-9 | 44-56 | 6 | 33,968 | Rick Waits | Dave Johnson | Dave Johnson | Rick Waits | Tom Burgmeier | 412 | 483 | -71 |
| 1977-08-02 | @ MIL | 101 | W 9-2 | 46-56 | 5 | 0 | Dennis Eckersley | Mike Caldwell | Dennis Eckersley | Mike Caldwell | | 421 | 485 | -64 |
| 1977-08-02 | @ MIL | 102 | W 7-4 | 46-56 | 5 | 12,658 | Wayne Garland | Bill Travers | Wayne Garland | Bill Castro | | 428 | 489 | -61 |
| 1977-08-03 | @ MIL | 103 | L 4-7 | 46-57 | 5 | 8,570 | Jim Bibby | Moose Haas | Eduardo Rodriguez | Pat Dobson | | 432 | 496 | -64 |
| 1977-08-05 | @ MIN | 104 | L 10-14 | 46-58 | 5 | 14,178 | Al Fitzmorris | Ron Schueler | Geoff Zahn | Sid Monge | Tom Johnson | 442 | 510 | -68 |
| 1977-08-06 | @ MIN | 105 | L 5-6 | 46-59 | 5 | 16,209 | Wayne Garland | Dave Johnson | Pete Redfern | Wayne Garland | | 447 | 516 | -69 |
| 1977-08-07 | @ MIN | 106 | L 1-11 | 46-60 | 6 | 21,801 | Dennis Eckersley | Dave Goltz | Dave Goltz | Dennis Eckersley | | 448 | 527 | -79 |
| 1977-08-08 | @ BAL | 107 | L 3-6 | 46-61 | 6 | 11,431 | Jim Bibby | Mike Flanagan | Dennis Martinez | Jim Bibby | | 451 | 533 | -82 |
| 1977-08-09 | @ BAL | 108 | L 1-3 | 46-62 | 6 | 8,797 | Al Fitzmorris | Ross Grimsley | Ross Grimsley | Al Fitzmorris | | 452 | 536 | -84 |
| 1977-08-10 | @ CHA | 109 | W 6-1 | 47-62 | 6 | 28,180 | Wayne Garland | Wilbur Wood | Wayne Garland | Wilbur Wood | | 458 | 537 | -79 |
| 1977-08-11 | @ CHA | 110 | W 3-1 | 48-62 | 5 | 19,017 | Rick Waits | Ken Kravec | Rick Waits | Ken Kravec | Jim Kern | 461 | 538 | -77 |
| 1977-08-12 | vs MIL | 111 | W 2-0 | 50-62 | 5 | 0 | Dennis Eckersley | Lary Sorensen | Dennis Eckersley | Lary Sorensen | | 463 | 538 | -75 |
| 1977-08-12 | vs MIL | 112 | W 5-4 | 50-62 | 5 | 16,168 | Don Hood | Eduardo Rodriguez | Jim Kern | Bob McClure | | 468 | 542 | -74 |
| 1977-08-13 | vs MIL | 113 | L 1-6 | 50-63 | 5 | 12,137 | Jim Bibby | Mike Caldwell | Mike Caldwell | Jim Bibby | | 469 | 548 | -79 |
| 1977-08-14 | vs MIL | 114 | W 12-4 | 52-63 | 5 | 0 | Wayne Garland | Jim Slaton | Wayne Garland | Jim Slaton | | 481 | 552 | -71 |
| 1977-08-14 | vs MIL | 115 | W 14-5 | 52-63 | 5 | 16,590 | Al Fitzmorris | Bill Travers | Al Fitzmorris | Bill Travers | | 495 | 557 | -62 |
| 1977-08-15 | vs OAK | 116 | W 7-2 | 53-63 | 5 | 7,186 | Rick Waits | Jim Umbarger | Rick Waits | Jim Umbarger | | 502 | 559 | -57 |
| 1977-08-16 | vs OAK | 117 | L 3-7 | 53-64 | 5 | 8,863 | Dennis Eckersley | Vida Blue | Vida Blue | Dennis Eckersley | | 505 | 566 | -61 |
| 1977-08-17 | vs KCA | 118 | L 3-5 | 53-65 | 5 | 5,921 | Jim Bibby | Paul Splittorff | Marty Pattin | Jim Bibby | Doug Bird | 508 | 571 | -63 |
| 1977-08-18 | vs KCA | 119 | L 0-4 | 53-66 | 5 | 6,692 | Wayne Garland | Dennis Leonard | Dennis Leonard | Wayne Garland | | 508 | 575 | -67 |
| 1977-08-19 | @ OAK | 120 | W 2-1 | 54-66 | 5 | 2,704 | Al Fitzmorris | Joe Coleman | Al Fitzmorris | Joe Coleman | Jim Kern | 510 | 576 | -66 |
| 1977-08-20 | @ OAK | 121 | W 5-4 | 55-66 | 5 | 5,022 | Rick Waits | Vida Blue | Jim Kern | Doug Bair | | 515 | 580 | -65 |
| 1977-08-21 | @ OAK | 122 | W 4-1 | 56-66 | 5 | 2,702 | Dennis Eckersley | Rick Langford | Dennis Eckersley | Rick Langford | | 519 | 581 | -62 |
| 1977-08-22 | @ SEA | 123 | W 12-1 | 57-67 | 5 | 0 | Jim Bibby | Bob Galasso | Jim Bibby | Bob Galasso | | 531 | 582 | -51 |
| 1977-08-22 | @ SEA | 124 | L 3-4 | 57-67 | 5 | 12,347 | Wayne Garland | John Montague | John Montague | Wayne Garland | | 534 | 586 | -52 |
| 1977-08-24 | @ CAL | 125 | W 5-3 | 58-68 | 5 | 0 | Al Fitzmorris | Nolan Ryan | Al Fitzmorris | Nolan Ryan | Jim Kern | 539 | 589 | -50 |
| 1977-08-24 | @ CAL | 126 | L 2-5 | 58-68 | 5 | 16,394 | Rick Waits | Ken Brett | Ken Brett | Rick Waits | Dave LaRoche | 541 | 594 | -53 |
| 1977-08-26 | vs SEA | 127 | L 2-4 | 58-69 | 5 | 6,707 | Wayne Garland | Paul Mitchell | Enrique Romo | Jim Kern | | 543 | 598 | -55 |
| 1977-08-27 | vs SEA | 128 | W 10-0 | 59-69 | 5 | 7,876 | Dennis Eckersley | Bob Galasso | Dennis Eckersley | Bob Galasso | | 553 | 598 | -45 |
| 1977-08-28 | vs SEA | 129 | W 10-6 | 60-69 | 5 | 9,599 | Jim Bibby | Glenn Abbott | Jim Bibby | Glenn Abbott | | 563 | 604 | -41 |
| 1977-08-29 | vs CHA | 130 | W 9-2 | 61-69 | 5 | 6,236 | Rick Waits | Steve Stone | Rick Waits | Steve Stone | | 572 | 606 | -34 |
| 1977-08-30 | vs CHA | 131 | L 1-3 | 61-70 | 5 | 7,662 | Wayne Garland | Ken Kravec | Ken Kravec | Wayne Garland | Dave Hamilton | 573 | 609 | -36 |
| 1977-08-31 | @ BOS | 132 | W 4-3 | 62-70 | 5 | 29,226 | Al Fitzmorris | Don Aase | Jim Kern | Bob Stanley | | 577 | 612 | -35 |
| 1977-09-01 | @ BOS | 133 | L 1-3 | 62-71 | 5 | 31,736 | Dennis Eckersley | Bill Lee | Bill Lee | Dennis Eckersley | Reggie Cleveland | 578 | 615 | -37 |
| 1977-09-02 | vs CAL | 134 | W 3-1 | 63-71 | 5 | 5,349 | Jim Bibby | Paul Hartzell | Jim Bibby | Paul Hartzell | Jim Kern | 581 | 616 | -35 |
| 1977-09-03 | vs CAL | 135 | L 2-3 | 63-72 | 5 | 11,054 | Wayne Garland | Nolan Ryan | Nolan Ryan | Wayne Garland | | 583 | 619 | -36 |
| 1977-09-04 | vs CAL | 136 | L 3-7 | 63-73 | 5 | 7,580 | Al Fitzmorris | Ken Brett | Ken Brett | Al Fitzmorris | | 586 | 626 | -40 |
| 1977-09-05 | vs NYA | 137 | W 4-3 | 65-73 | 5 | 0 | Don Hood | Catfish Hunter | Don Hood | Catfish Hunter | Jim Kern | 590 | 629 | -39 |
| 1977-09-05 | vs NYA | 138 | W 5-4 | 65-73 | 5 | 28,184 | Rick Waits | Mike Torrez | Jim Kern | Mike Torrez | Jim Bibby | 595 | 633 | -38 |
| 1977-09-06 | vs NYA | 139 | L 3-8 | 65-74 | 5 | 8,123 | Dennis Eckersley | Dick Tidrow | Dick Tidrow | Dennis Eckersley | Sparky Lyle | 598 | 641 | -43 |
| 1977-09-07 | vs NYA | 140 | L 3-4 | 65-75 | 5 | 7,924 | Wayne Garland | Ron Guidry | Ron Guidry | Wayne Garland | | 601 | 645 | -44 |
| 1977-09-08 | vs NYA | 141 | L 3-4 | 65-76 | 5 | 4,930 | Jim Bibby | Ed Figueroa | Ed Figueroa | Jim Bibby | | 604 | 649 | -45 |
| 1977-09-09 | @ BAL | 142 | L 1-7 | 65-77 | 5 | 5,930 | Al Fitzmorris | Rudy May | Rudy May | Al Fitzmorris | | 605 | 656 | -51 |
| 1977-09-10 | @ BAL | 143 | L 5-6 | 65-78 | 5 | 8,748 | Rick Waits | Mike Flanagan | Dennis Martinez | Jim Kern | | 610 | 662 | -52 |
| 1977-09-11 | @ BAL | 144 | L 5-9 | 65-79 | 5 | 12,540 | Pat Dobson | Ross Grimsley | Ross Grimsley | Pat Dobson | | 615 | 671 | -56 |
| 1977-09-12 | vs DET | 145 | W 8-1 | 66-79 | 5 | 3,032 | Wayne Garland | Jim Crawford | Wayne Garland | Jim Crawford | | 623 | 672 | -49 |
| 1977-09-14 | vs DET | 146 | L 3-5 | 66-81 | 5 | 0 | Jim Bibby | Bob Sykes | Bob Sykes | Jim Bibby | Bruce Taylor | 626 | 677 | -51 |
| 1977-09-14 | vs DET | 147 | L 1-2 | 66-81 | 5 | 4,151 | Don Hood | Milt Wilcox | John Hiller | Jim Kern | Steve Foucault | 627 | 679 | -52 |
| 1977-09-17 | vs TOR | 148 | W 6-3 | 67-82 | 5 | 0 | Dennis Eckersley | Jeff Byrd | Dennis Eckersley | Jeff Byrd | Pat Dobson | 633 | 682 | -49 |
| 1977-09-17 | vs TOR | 149 | L 5-6 | 67-82 | 5 | 5,593 | Rick Waits | Dave Lemanczyk | Dave Lemanczyk | Rick Waits | Tom Murphy | 638 | 688 | -50 |
| 1977-09-18 | vs TOR | 150 | L 4-7 | 67-83 | 5 | 4,376 | Wayne Garland | Jesse Jefferson | Jesse Jefferson | Wayne Garland | Pete Vuckovich | 642 | 695 | -53 |
| 1977-09-19 | @ DET | 151 | L 4-6 | 67-84 | 5 | 5,843 | Jim Bibby | Milt Wilcox | Steve Foucault | Pat Dobson | | 646 | 701 | -55 |
| 1977-09-20 | @ DET | 152 | L 4-5 | 67-85 | 5 | 5,557 | Don Hood | Ed Glynn | Steve Foucault | Rick Waits | | 650 | 706 | -56 |
| 1977-09-23 | vs BAL | 153 | W 3-2 | 68-85 | 5 | 4,787 | Rick Waits | Rudy May | Rick Waits | Rudy May | Jim Bibby | 653 | 708 | -55 |
| 1977-09-24 | vs BAL | 154 | L 1-4 | 68-86 | 5 | 4,098 | Dennis Eckersley | Jim Palmer | Jim Palmer | Dennis Eckersley | | 654 | 712 | -58 |
| 1977-09-25 | vs BAL | 155 | W 9-4 | 69-86 | 5 | 6,291 | Wayne Garland | Ross Grimsley | Wayne Garland | Ross Grimsley | | 663 | 716 | -53 |
| 1977-09-26 | @ NYA | 156 | L 2-4 | 69-87 | 5 | 12,356 | Don Hood | Mike Torrez | Mike Torrez | Don Hood | Sparky Lyle | 665 | 720 | -55 |
| 1977-09-27 | @ NYA | 157 | L 1-2 | 69-88 | 5 | 14,138 | Rick Waits | Dick Tidrow | Sparky Lyle | Jim Bibby | | 666 | 722 | -56 |
| 1977-09-28 | @ NYA | 158 | L 0-10 | 69-89 | 5 | 18,430 | Al Fitzmorris | Don Gullett | Don Gullett | Al Fitzmorris | | 666 | 732 | -66 |
| 1977-09-29 | @ NYA | 159 | W 4-1 | 70-89 | 5 | 15,793 | Wayne Garland | Ed Figueroa | Wayne Garland | Ed Figueroa | | 670 | 733 | -63 |
| 1977-10-02 | @ TOR | 160 | L 1-2 | 71-90 | 5 | 0 | Jim Bibby | Dave Lemanczyk | Dave Lemanczyk | Larry Andersen | | 671 | 735 | -64 |
| 1977-10-02 | @ TOR | 161 | W 5-4 | 71-90 | 5 | 27,789 | Cardell Camper | Jim Clancy | Cardell Camper | Jim Clancy | Rick Waits | 676 | 739 | -63 |