| 1977-04-07 | vs NYN | 1 | L 3-5 | 0-1 | 3 | 39,937 | Ray Burris | Tom Seaver | Tom Seaver | Ray Burris | Skip Lockwood | 3 | 5 | -2 |
| 1977-04-09 | vs NYN | 2 | L 6-8 | 0-2 | 4 | 17,848 | Mike Krukow | Jerry Koosman | Nino Espinosa | Jim Todd | | 9 | 13 | -4 |
| 1977-04-10 | vs NYN | 3 | W 5-2 | 1-2 | 4 | 14,102 | Rick Reuschel | Jon Matlack | Rick Reuschel | Jon Matlack | Bruce Sutter | 14 | 15 | -1 |
| 1977-04-11 | @ PHI | 4 | W 6-2 | 2-2 | 4 | 17,578 | Bill Bonham | Wayne Twitchell | Bill Bonham | Wayne Twitchell | | 20 | 17 | 3 |
| 1977-04-13 | @ PHI | 5 | W 3-1 | 3-2 | 2 | 16,434 | Ray Burris | Randy Lerch | Ray Burris | Randy Lerch | Bruce Sutter | 23 | 18 | 5 |
| 1977-04-15 | @ NYN | 6 | W 8-4 | 4-2 | 2 | 6,148 | Mike Krukow | Jon Matlack | Paul Reuschel | Skip Lockwood | | 31 | 22 | 9 |
| 1977-04-16 | @ NYN | 7 | L 1-4 | 4-3 | 2 | 11,423 | Rick Reuschel | Nino Espinosa | Nino Espinosa | Rick Reuschel | | 32 | 26 | 6 |
| 1977-04-17 | @ NYN | 8 | L 0-6 | 4-4 | 4 | 35,337 | Bill Bonham | Tom Seaver | Tom Seaver | Bill Bonham | | 32 | 32 | 0 |
| 1977-04-18 | vs PHI | 9 | L 1-3 | 4-5 | 4 | 3,777 | Ray Burris | Randy Lerch | Randy Lerch | Ray Burris | Ron Reed | 33 | 35 | -2 |
| 1977-04-19 | vs PHI | 10 | L 5-7 | 4-6 | 4 | 2,413 | Mike Krukow | Larry Christenson | Larry Christenson | Mike Krukow | Gene Garber | 38 | 42 | -4 |
| 1977-04-23 | vs CIN | 11 | W 2-1 | 5-6 | 4 | 14,454 | Bill Bonham | Pat Zachry | Bill Bonham | Pat Zachry | Bruce Sutter | 40 | 43 | -3 |
| 1977-04-24 | vs CIN | 12 | W 7-1 | 6-6 | 4 | 18,651 | Ray Burris | Woodie Fryman | Ray Burris | Woodie Fryman | | 47 | 44 | 3 |
| 1977-04-26 | vs SLN | 13 | W 4-1 | 7-6 | 3 | 6,245 | Rick Reuschel | Eric Rasmussen | Rick Reuschel | Eric Rasmussen | | 51 | 45 | 6 |
| 1977-04-27 | vs SLN | 14 | L 3-21 | 7-7 | 4 | 9,248 | Mike Krukow | John Denny | John Denny | Mike Krukow | | 54 | 66 | -12 |
| 1977-04-29 | @ CIN | 15 | L 2-3 | 7-8 | 4 | 34,452 | Bill Bonham | Woodie Fryman | Woodie Fryman | Bill Bonham | Rawly Eastwick | 56 | 69 | -13 |
| 1977-04-30 | @ CIN | 16 | L 0-8 | 7-9 | 5 | 26,774 | Ray Burris | Jack Billingham | Jack Billingham | Ray Burris | | 56 | 77 | -21 |
| 1977-05-01 | @ CIN | 17 | W 4-1 | 8-9 | 5 | 46,418 | Rick Reuschel | Pat Zachry | Rick Reuschel | Pat Zachry | Bruce Sutter | 60 | 78 | -18 |
| 1977-05-03 | vs HOU | 18 | W 9-0 | 9-9 | 4 | 1,795 | Ray Burris | J.R. Richard | Ray Burris | J.R. Richard | | 69 | 78 | -9 |
| 1977-05-04 | vs HOU | 19 | L 4-5 | 9-10 | 4 | 3,044 | Bill Bonham | Joaquin Andujar | Ken Forsch | Bruce Sutter | Bo McLaughlin | 73 | 83 | -10 |
| 1977-05-05 | vs HOU | 20 | W 8-7 | 10-10 | 4 | 3,645 | Rick Reuschel | Floyd Bannister | Rick Reuschel | Floyd Bannister | Bruce Sutter | 81 | 90 | -9 |
| 1977-05-06 | vs ATL | 21 | W 7-2 | 11-10 | 3 | 3,405 | Mike Krukow | Buzz Capra | Mike Krukow | Buzz Capra | Paul Reuschel | 88 | 92 | -4 |
| 1977-05-07 | vs ATL | 22 | W 11-4 | 12-10 | 3 | 22,877 | Ray Burris | Phil Niekro | Ray Burris | Phil Niekro | | 99 | 96 | 3 |
| 1977-05-08 | vs ATL | 23 | W 6-3 | 13-10 | 3 | 10,450 | Bill Bonham | Max Leon | Bill Bonham | Max Leon | Bruce Sutter | 105 | 99 | 6 |
| 1977-05-09 | @ HOU | 24 | W 6-1 | 14-10 | 3 | 7,424 | Rick Reuschel | Joaquin Andujar | Rick Reuschel | Joaquin Andujar | Guillermo Hernandez | 111 | 100 | 11 |
| 1977-05-10 | @ HOU | 25 | W 11-5 | 15-10 | 3 | 7,070 | Mike Krukow | Floyd Bannister | Mike Krukow | Floyd Bannister | | 122 | 105 | 17 |
| 1977-05-11 | @ HOU | 26 | L 2-8 | 15-11 | 3 | 5,436 | Ray Burris | J.R. Richard | J.R. Richard | Ray Burris | | 124 | 113 | 11 |
| 1977-05-13 | @ MON | 27 | W 5-3 | 16-11 | 3 | 12,591 | Bill Bonham | Dan Warthen | Bill Bonham | Dan Warthen | Bruce Sutter | 129 | 116 | 13 |
| 1977-05-14 | @ MON | 28 | W 6-3 | 17-11 | 3 | 14,208 | Rick Reuschel | Steve Rogers | Rick Reuschel | Steve Rogers | Bruce Sutter | 135 | 119 | 16 |
| 1977-05-15 | @ MON | 29 | W 4-3 | 19-11 | 2 | 0 | Ray Burris | Don Stanhouse | Ray Burris | Don Stanhouse | Bruce Sutter | 139 | 122 | 17 |
| 1977-05-15 | @ MON | 30 | W 4-2 | 19-11 | 2 | 31,186 | Mike Krukow | Jackie Brown | Mike Krukow | Jackie Brown | Paul Reuschel | 143 | 124 | 19 |
| 1977-05-16 | vs SDN | 31 | W 9-6 | 20-11 | 2 | 6,992 | Donnie Moore | Bob Shirley | Jim Todd | Bob Shirley | Paul Reuschel | 152 | 130 | 22 |
| 1977-05-17 | vs SDN | 32 | W 23-6 | 21-11 | 2 | 9,838 | Bill Bonham | Tom Griffin | Bill Bonham | Tom Griffin | Ramon Hernandez | 175 | 136 | 39 |
| 1977-05-19 | @ ATL | 33 | L 0-6 | 21-12 | 2 | 8,923 | Rick Reuschel | Phil Niekro | Phil Niekro | Rick Reuschel | | 175 | 142 | 33 |
| 1977-05-20 | @ ATL | 34 | W 13-4 | 22-12 | 2 | 11,451 | Ray Burris | Don Collins | Ray Burris | Don Collins | | 188 | 146 | 42 |
| 1977-05-21 | @ ATL | 35 | W 9-3 | 23-12 | 2 | 11,842 | Mike Krukow | Max Leon | Donnie Moore | Max Leon | Bruce Sutter | 197 | 149 | 48 |
| 1977-05-22 | @ ATL | 36 | L 2-5 | 23-13 | 2 | 7,635 | Bill Bonham | Andy Messersmith | Andy Messersmith | Bill Bonham | Jamie Easterly | 199 | 154 | 45 |
| 1977-05-24 | vs MON | 37 | L 4-5 | 24-13 | 2 | 10,248 | Rick Reuschel | Don Stanhouse | Joe Kerrigan | Guillermo Hernandez | Santo Alcala | 203 | 159 | 44 |
| 1977-05-25 | vs MON | 38 | W 7-3 | 25-13 | 2 | 9,088 | Ray Burris | Dan Warthen | Ray Burris | Dan Warthen | Bruce Sutter | 210 | 162 | 48 |
| 1977-05-26 | vs MON | 39 | W 1-0 | 26-13 | 2 | 7,893 | Mike Krukow | Steve Rogers | Mike Krukow | Steve Rogers | | 211 | 162 | 49 |
| 1977-05-27 | vs PIT | 40 | W 4-2 | 27-13 | 1 | 14,593 | Bill Bonham | John Candelaria | Bill Bonham | John Candelaria | Bruce Sutter | 215 | 164 | 51 |
| 1977-05-28 | vs PIT | 41 | W 6-3 | 28-13 | 1 | 34,779 | Rick Reuschel | Jim Rooker | Paul Reuschel | Jim Rooker | Bruce Sutter | 221 | 167 | 54 |
| 1977-05-29 | vs PIT | 42 | W 3-2 | 29-13 | 1 | 39,517 | Ray Burris | Jerry Reuss | Guillermo Hernandez | Rich Gossage | Bruce Sutter | 224 | 169 | 55 |
| 1977-05-30 | @ SLN | 43 | L 0-14 | 29-14 | 1 | 25,241 | Mike Krukow | Pete Falcone | Pete Falcone | Mike Krukow | | 224 | 183 | 41 |
| 1977-05-31 | @ SLN | 44 | L 0-6 | 29-15 | 1 | 17,036 | Bill Bonham | John Denny | John Denny | Bill Bonham | | 224 | 189 | 35 |
| 1977-06-01 | @ SLN | 45 | W 4-3 | 30-15 | 1 | 21,383 | Rick Reuschel | Larry Dierker | Guillermo Hernandez | Buddy Schultz | | 228 | 192 | 36 |
| 1977-06-03 | @ PIT | 46 | L 0-5 | 30-16 | 1 | 20,152 | Ray Burris | Jim Rooker | Jim Rooker | Ray Burris | | 228 | 197 | 31 |
| 1977-06-04 | @ PIT | 47 | W 4-3 | 31-16 | 1 | 26,202 | Mike Krukow | Jerry Reuss | Mike Krukow | Jerry Reuss | Bruce Sutter | 232 | 200 | 32 |
| 1977-06-05 | @ PIT | 48 | L 4-5 | 31-17 | 1 | 51,580 | Bill Bonham | Odell Jones | Odell Jones | Bill Bonham | Rich Gossage | 236 | 205 | 31 |
| 1977-06-06 | vs LAN | 49 | W 3-1 | 32-17 | 1 | 13,168 | Rick Reuschel | Burt Hooton | Rick Reuschel | Burt Hooton | Bruce Sutter | 239 | 206 | 33 |
| 1977-06-07 | vs LAN | 50 | W 10-4 | 33-17 | 1 | 19,491 | Ray Burris | Tommy John | Ray Burris | Tommy John | | 249 | 210 | 39 |
| 1977-06-08 | vs LAN | 51 | L 2-4 | 33-18 | 1 | 18,276 | Mike Krukow | Don Sutton | Don Sutton | Mike Krukow | | 251 | 214 | 37 |
| 1977-06-09 | vs SFN | 52 | W 1-0 | 34-18 | 1 | 9,772 | Bill Bonham | Ed Halicki | Bruce Sutter | Randy Moffitt | | 252 | 214 | 38 |
| 1977-06-10 | vs SFN | 53 | W 3-1 | 35-18 | 1 | 12,642 | Rick Reuschel | Bob Knepper | Rick Reuschel | Bob Knepper | | 255 | 215 | 40 |
| 1977-06-11 | vs SFN | 54 | W 5-3 | 36-18 | 1 | 32,411 | Ray Burris | Jim Barr | Guillermo Hernandez | Gary Lavelle | Bruce Sutter | 260 | 218 | 42 |
| 1977-06-12 | vs SFN | 55 | W 6-5 | 37-18 | 1 | 27,038 | Mike Krukow | John Curtis | Bruce Sutter | Gary Lavelle | | 266 | 223 | 43 |
| 1977-06-14 | @ SDN | 56 | W 6-5 | 38-18 | 1 | 15,801 | Bill Bonham | Tom Griffin | Donnie Moore | Rollie Fingers | | 272 | 228 | 44 |
| 1977-06-15 | @ SDN | 57 | W 2-0 | 39-18 | 1 | 14,931 | Rick Reuschel | Bob Owchinko | Rick Reuschel | Bob Owchinko | | 274 | 228 | 46 |
| 1977-06-16 | @ SDN | 58 | L 6-8 | 39-19 | 1 | 10,748 | Ray Burris | Bob Shirley | Bob Shirley | Ray Burris | Dan Spillner | 280 | 236 | 44 |
| 1977-06-17 | @ LAN | 59 | W 7-3 | 40-19 | 1 | 52,487 | Mike Krukow | Burt Hooton | Bruce Sutter | Stan Wall | | 287 | 239 | 48 |
| 1977-06-18 | @ LAN | 60 | L 1-2 | 40-20 | 1 | 45,655 | Bill Bonham | Tommy John | Tommy John | Bill Bonham | | 288 | 241 | 47 |
| 1977-06-19 | @ LAN | 61 | L 1-3 | 40-21 | 1 | 44,174 | Rick Reuschel | Don Sutton | Don Sutton | Guillermo Hernandez | | 289 | 244 | 45 |
| 1977-06-20 | @ SFN | 62 | W 10-9 | 41-21 | 1 | 4,344 | Ray Burris | Jim Barr | Donnie Moore | Terry Cornutt | Rick Reuschel | 299 | 253 | 46 |
| 1977-06-21 | @ SFN | 63 | W 8-2 | 42-21 | 1 | 17,610 | Mike Krukow | John Curtis | Mike Krukow | John Curtis | Steve Renko | 307 | 255 | 52 |
| 1977-06-22 | @ SFN | 64 | W 4-2 | 43-21 | 1 | 7,000 | Bill Bonham | Ed Halicki | Bill Bonham | Ed Halicki | Bruce Sutter | 311 | 257 | 54 |
| 1977-06-24 | vs NYN | 65 | W 5-0 | 44-21 | 1 | 26,624 | Rick Reuschel | Jerry Koosman | Rick Reuschel | Jerry Koosman | Guillermo Hernandez | 316 | 257 | 59 |
| 1977-06-25 | vs NYN | 66 | W 5-4 | 45-21 | 1 | 33,130 | Ray Burris | Pat Zachry | Ray Burris | Bob Apodaca | | 321 | 261 | 60 |
| 1977-06-26 | vs NYN | 67 | W 5-2 | 46-21 | 1 | 36,698 | Mike Krukow | Jon Matlack | Mike Krukow | Jon Matlack | Bruce Sutter | 326 | 263 | 63 |
| 1977-06-27 | @ MON | 68 | W 4-3 | 47-21 | 1 | 14,197 | Bill Bonham | Santo Alcala | Bill Bonham | Santo Alcala | Bruce Sutter | 330 | 266 | 64 |
| 1977-06-28 | @ MON | 69 | W 4-2 | 48-21 | 1 | 18,955 | Rick Reuschel | Wayne Twitchell | Rick Reuschel | Will McEnaney | Bruce Sutter | 334 | 268 | 66 |
| 1977-06-29 | @ MON | 70 | L 0-5 | 48-22 | 1 | 13,249 | Ray Burris | Jackie Brown | Jackie Brown | Ray Burris | | 334 | 273 | 61 |
| 1977-06-30 | @ SLN | 71 | L 1-2 | 48-23 | 1 | 29,493 | Steve Renko | Bob Forsch | Rawly Eastwick | Guillermo Hernandez | | 335 | 275 | 60 |
| 1977-07-01 | @ SLN | 72 | L 1-3 | 48-24 | 1 | 33,593 | Mike Krukow | Larry Dierker | Larry Dierker | Mike Krukow | Rawly Eastwick | 336 | 278 | 58 |
| 1977-07-02 | @ SLN | 73 | L 3-10 | 48-25 | 1 | 50,340 | Bill Bonham | Pete Falcone | Pete Falcone | Bill Bonham | | 339 | 288 | 51 |
| 1977-07-03 | @ SLN | 74 | W 4-0 | 49-25 | 1 | 42,885 | Rick Reuschel | Eric Rasmussen | Bruce Sutter | Eric Rasmussen | | 343 | 288 | 55 |
| 1977-07-04 | vs MON | 75 | L 3-19 | 49-27 | 1 | 0 | Ray Burris | Jackie Brown | Jackie Brown | Ray Burris | | 346 | 307 | 39 |
| 1977-07-04 | vs MON | 76 | L 6-7 | 49-27 | 1 | 31,641 | Steve Renko | Steve Rogers | Bill Atkinson | Paul Reuschel | Will McEnaney | 352 | 314 | 38 |
| 1977-07-05 | vs MON | 77 | L 8-9 | 49-28 | 1 | 9,780 | Mike Krukow | Stan Bahnsen | Stan Bahnsen | Mike Krukow | Will McEnaney | 360 | 323 | 37 |
| 1977-07-06 | vs MON | 78 | W 8-6 | 50-28 | 1 | 23,854 | Bill Bonham | Don Stanhouse | Bill Bonham | Don Stanhouse | Bruce Sutter | 368 | 329 | 39 |
| 1977-07-07 | vs SLN | 79 | W 2-0 | 51-28 | 1 | 27,864 | Rick Reuschel | Larry Dierker | Rick Reuschel | Larry Dierker | | 370 | 329 | 41 |
| 1977-07-08 | vs SLN | 80 | W 7-6 | 52-28 | 1 | 27,088 | Ray Burris | Eric Rasmussen | Paul Reuschel | Rawly Eastwick | Bruce Sutter | 377 | 335 | 42 |
| 1977-07-09 | vs SLN | 81 | L 3-4 | 52-29 | 1 | 33,424 | Steve Renko | Tom Underwood | Tom Underwood | Steve Renko | Clay Carroll | 380 | 339 | 41 |
| 1977-07-10 | vs SLN | 82 | L 3-8 | 53-30 | 1 | 0 | Bill Bonham | Bob Forsch | Bob Forsch | Bill Bonham | | 383 | 347 | 36 |
| 1977-07-10 | vs SLN | 83 | W 4-3 | 53-30 | 1 | 40,038 | Mike Krukow | Pete Falcone | Bruce Sutter | Al Hrabosky | | 387 | 350 | 37 |
| 1977-07-12 | @ NYN | 84 | L 2-4 | 53-31 | 1 | 8,093 | Rick Reuschel | Jon Matlack | Jon Matlack | Rick Reuschel | Skip Lockwood | 389 | 354 | 35 |
| 1977-07-13 | @ NYN | 85 | W 5-2 | 54-31 | 1 | 14,626 | Ray Burris | Jerry Koosman | Ray Burris | Jerry Koosman | | 394 | 356 | 38 |
| 1977-07-15 | @ PHI | 86 | L 2-4 | 54-33 | 1 | 0 | Bill Bonham | Larry Christenson | Larry Christenson | Bill Bonham | Tug McGraw | 396 | 360 | 36 |
| 1977-07-15 | @ PHI | 87 | L 2-9 | 54-33 | 1 | 61,177 | Mike Krukow | Jim Lonborg | Jim Lonborg | Mike Krukow | | 398 | 369 | 29 |
| 1977-07-16 | @ PHI | 88 | W 9-8 | 55-33 | 1 | 35,095 | Rick Reuschel | Randy Lerch | Pete Broberg | Ron Reed | Bruce Sutter | 407 | 377 | 30 |
| 1977-07-17 | @ PHI | 89 | L 2-4 | 55-34 | 1 | 36,338 | Ray Burris | Steve Carlton | Steve Carlton | Ray Burris | Tug McGraw | 409 | 381 | 28 |
| 1977-07-21 | vs ATL | 90 | W 4-3 | 56-34 | 1 | 20,895 | Bill Bonham | Phil Niekro | Paul Reuschel | Rick Camp | | 413 | 384 | 29 |
| 1977-07-22 | vs ATL | 91 | W 1-0 | 57-34 | 1 | 17,026 | Rick Reuschel | Dick Ruthven | Rick Reuschel | Dick Ruthven | | 414 | 384 | 30 |
| 1977-07-23 | vs ATL | 92 | L 4-5 | 57-35 | 1 | 26,224 | Mike Krukow | Eddie Solomon | Rick Camp | Paul Reuschel | | 418 | 389 | 29 |
| 1977-07-24 | vs HOU | 93 | L 6-10 | 57-37 | 1 | 0 | Ray Burris | Gene Pentz | Gene Pentz | Ray Burris | Joe Sambito | 424 | 399 | 25 |
| 1977-07-24 | vs HOU | 94 | L 4-6 | 57-37 | 1 | 25,963 | Steve Renko | Joe Niekro | Joe Niekro | Donnie Moore | | 428 | 405 | 23 |
| 1977-07-25 | vs HOU | 95 | W 9-7 | 58-37 | 1 | 14,577 | Bill Bonham | Floyd Bannister | Guillermo Hernandez | Mark Lemongello | | 437 | 412 | 25 |
| 1977-07-26 | vs CIN | 96 | W 3-0 | 59-37 | 1 | 38,113 | Rick Reuschel | Fred Norman | Rick Reuschel | Fred Norman | | 440 | 412 | 28 |
| 1977-07-27 | vs CIN | 97 | L 2-6 | 60-38 | 1 | 0 | Mike Krukow | Mario Soto | Mario Soto | Mike Krukow | | 442 | 418 | 24 |
| 1977-07-27 | vs CIN | 98 | W 5-1 | 60-38 | 1 | 41,105 | Steve Renko | Doug Capilla | Steve Renko | Doug Capilla | | 447 | 419 | 28 |
| 1977-07-28 | vs CIN | 99 | W 16-15 | 61-38 | 1 | 32,155 | Ray Burris | Dale Murray | Rick Reuschel | Jack Billingham | | 463 | 434 | 29 |
| 1977-07-29 | @ HOU | 100 | L 0-1 | 61-39 | 1 | 23,208 | Bill Bonham | Joe Niekro | Joe Niekro | Bill Bonham | | 463 | 435 | 28 |
| 1977-07-30 | @ HOU | 101 | L 3-11 | 61-40 | 1 | 42,916 | Rick Reuschel | Tom Dixon | Joe Sambito | Paul Reuschel | | 466 | 446 | 20 |
| 1977-07-31 | @ HOU | 102 | W 4-1 | 62-40 | 1 | 20,094 | Ray Burris | J.R. Richard | Ray Burris | J.R. Richard | | 470 | 447 | 23 |
| 1977-08-01 | @ CIN | 103 | L 6-7 | 62-41 | 1 | 35,385 | Steve Renko | Tom Seaver | Pedro Borbon | Paul Reuschel | | 476 | 454 | 22 |
| 1977-08-02 | @ CIN | 104 | W 5-2 | 63-41 | 1 | 34,091 | Bill Bonham | Mario Soto | Guillermo Hernandez | Mario Soto | Dave Roberts | 481 | 456 | 25 |
| 1977-08-03 | @ CIN | 105 | L 3-5 | 63-42 | 1 | 38,505 | Rick Reuschel | Paul Moskau | Pedro Borbon | Guillermo Hernandez | | 484 | 461 | 23 |
| 1977-08-05 | vs SDN | 106 | L 8-11 | 63-43 | 1 | 17,985 | Ray Burris | Dave Wehrmeister | Dave Tomlin | Ray Burris | Rollie Fingers | 492 | 472 | 20 |
| 1977-08-06 | vs SDN | 107 | W 10-5 | 64-43 | 1 | 21,146 | Bill Bonham | Randy Jones | Bill Bonham | Randy Jones | Paul Reuschel | 502 | 477 | 25 |
| 1977-08-07 | vs SDN | 108 | L 6-8 | 65-44 | 1 | 0 | Mike Krukow | Bob Owchinko | Bob Owchinko | Mike Krukow | Dan Spillner | 508 | 485 | 23 |
| 1977-08-07 | vs SDN | 109 | W 9-4 | 65-44 | 1 | 30,099 | Steve Renko | Bob Shirley | Steve Renko | Bob Shirley | | 517 | 489 | 28 |
| 1977-08-08 | @ PIT | 110 | L 6-7 | 65-45 | 2 | 25,802 | Rick Reuschel | Bruce Kison | Grant Jackson | Rick Reuschel | | 523 | 496 | 27 |
| 1977-08-09 | @ PIT | 111 | W 4-1 | 66-45 | 1 | 28,341 | Ray Burris | Jerry Reuss | Ray Burris | Jerry Reuss | Guillermo Hernandez | 527 | 497 | 30 |
| 1977-08-10 | @ PIT | 112 | L 1-2 | 66-46 | 2 | 32,831 | Dave Roberts | John Candelaria | Larry Demery | Pete Broberg | | 528 | 499 | 29 |
| 1977-08-12 | vs PHI | 113 | L 3-10 | 66-47 | 2 | 28,849 | Rick Reuschel | Steve Carlton | Steve Carlton | Rick Reuschel | | 531 | 509 | 22 |
| 1977-08-13 | vs PHI | 114 | L 7-10 | 66-48 | 3 | 27,126 | Ray Burris | Randy Lerch | Ron Reed | Dave Giusti | Gene Garber | 538 | 519 | 19 |
| 1977-08-14 | vs PHI | 115 | L 2-10 | 66-50 | 3 | 0 | Mike Krukow | Larry Christenson | Larry Christenson | Mike Krukow | | 540 | 529 | 11 |
| 1977-08-14 | vs PHI | 116 | L 2-4 | 66-50 | 3 | 33,351 | Steve Renko | Jim Lonborg | Jim Lonborg | Steve Renko | Ron Reed | 542 | 533 | 9 |
| 1977-08-16 | vs PIT | 117 | W 6-5 | 67-50 | 3 | 24,039 | Bill Bonham | Bruce Kison | Guillermo Hernandez | Larry Demery | | 548 | 538 | 10 |
| 1977-08-17 | vs PIT | 118 | W 4-2 | 68-50 | 2 | 29,786 | Rick Reuschel | Jim Rooker | Rick Reuschel | Jim Rooker | | 552 | 540 | 12 |
| 1977-08-18 | vs PIT | 119 | L 6-7 | 68-51 | 3 | 24,027 | Ray Burris | Jerry Reuss | Jerry Reuss | Ray Burris | Kent Tekulve | 558 | 547 | 11 |
| 1977-08-19 | vs LAN | 120 | W 6-2 | 69-51 | 3 | 23,031 | Mike Krukow | Tommy John | Mike Krukow | Tommy John | | 564 | 549 | 15 |
| 1977-08-20 | vs LAN | 121 | W 5-4 | 70-51 | 2 | 27,095 | Bill Bonham | Doug Rau | Guillermo Hernandez | Charlie Hough | Dave Giusti | 569 | 553 | 16 |
| 1977-08-21 | vs LAN | 122 | L 1-5 | 70-52 | 2 | 26,174 | Dennis Lamp | Rick Rhoden | Rick Rhoden | Dennis Lamp | Lance Rautzhan | 570 | 558 | 12 |
| 1977-08-22 | vs SFN | 123 | W 3-2 | 71-52 | 2 | 19,085 | Rick Reuschel | Jim Barr | Rick Reuschel | Jim Barr | Guillermo Hernandez | 573 | 560 | 13 |
| 1977-08-23 | vs SFN | 124 | L 3-4 | 71-53 | 2 | 23,347 | Ray Burris | Bob Knepper | Charlie Williams | Paul Reuschel | | 576 | 564 | 12 |
| 1977-08-24 | @ ATL | 125 | L 3-4 | 71-54 | 2 | 4,649 | Mike Krukow | Eddie Solomon | Don Collins | Guillermo Hernandez | Dave Campbell | 579 | 568 | 11 |
| 1977-08-25 | @ ATL | 126 | L 6-8 | 71-55 | 3 | 4,164 | Bill Bonham | Dick Ruthven | Dick Ruthven | Bill Bonham | Mike Davey | 585 | 576 | 9 |
| 1977-08-26 | @ SFN | 127 | W 5-2 | 72-55 | 3 | 4,719 | Rick Reuschel | Jim Barr | Rick Reuschel | Jim Barr | Bruce Sutter | 590 | 578 | 12 |
| 1977-08-27 | @ SFN | 128 | L 1-7 | 72-56 | 3 | 6,587 | Ray Burris | Bob Knepper | Bob Knepper | Ray Burris | | 591 | 585 | 6 |
| 1977-08-28 | @ SFN | 129 | L 1-4 | 72-57 | 3 | 21,622 | Dave Roberts | Ed Halicki | Ed Halicki | Dave Roberts | | 592 | 589 | 3 |
| 1977-08-29 | @ LAN | 130 | L 1-4 | 72-58 | 3 | 34,345 | Mike Krukow | Tommy John | Tommy John | Mike Krukow | Mike Garman | 593 | 593 | 0 |
| 1977-08-30 | @ LAN | 131 | W 4-1 | 73-58 | 3 | 40,663 | Rick Reuschel | Doug Rau | Rick Reuschel | Doug Rau | Bruce Sutter | 597 | 594 | 3 |
| 1977-08-31 | @ LAN | 132 | L 0-5 | 73-59 | 3 | 35,934 | Ray Burris | Rick Rhoden | Rick Rhoden | Ray Burris | | 597 | 599 | -2 |
| 1977-09-02 | @ SDN | 133 | L 0-5 | 73-60 | 3 | 10,717 | Mike Krukow | Randy Jones | Randy Jones | Mike Krukow | Rollie Fingers | 597 | 604 | -7 |
| 1977-09-03 | @ SDN | 134 | L 1-4 | 73-61 | 3 | 10,970 | Rick Reuschel | Dave Freisleben | Dan Spillner | Rick Reuschel | | 598 | 608 | -10 |
| 1977-09-04 | @ SDN | 135 | W 2-1 | 74-61 | 3 | 15,506 | Ray Burris | Bob Shirley | Ray Burris | Dan Spillner | Bruce Sutter | 600 | 609 | -9 |
| 1977-09-05 | vs SLN | 136 | W 4-2 | 75-61 | 3 | 33,982 | Dave Roberts | Eric Rasmussen | Dave Roberts | Eric Rasmussen | | 604 | 611 | -7 |
| 1977-09-06 | vs SLN | 137 | L 1-3 | 75-62 | 3 | 9,600 | Guillermo Hernandez | Tom Underwood | Tom Underwood | Guillermo Hernandez | | 605 | 614 | -9 |
| 1977-09-07 | vs MON | 138 | L 2-4 | 75-63 | 3 | 3,768 | Rick Reuschel | Stan Bahnsen | Stan Bahnsen | Rick Reuschel | Don Stanhouse | 607 | 618 | -11 |
| 1977-09-08 | vs MON | 139 | W 3-2 | 76-63 | 3 | 2,841 | Ray Burris | Steve Rogers | Bruce Sutter | Joe Kerrigan | | 610 | 620 | -10 |
| 1977-09-09 | vs NYN | 140 | W 10-8 | 77-63 | 3 | 3,983 | Mike Krukow | Craig Swan | Bruce Sutter | Bob Apodaca | | 620 | 628 | -8 |
| 1977-09-10 | vs NYN | 141 | L 2-7 | 77-64 | 3 | 16,256 | Bill Bonham | Jerry Koosman | Skip Lockwood | Donnie Moore | | 622 | 635 | -13 |
| 1977-09-11 | vs NYN | 142 | L 3-7 | 77-65 | 3 | 21,404 | Rick Reuschel | Jackson Todd | Bob Myrick | Rick Reuschel | Skip Lockwood | 625 | 642 | -17 |
| 1977-09-12 | @ SLN | 143 | L 9-11 | 77-66 | 3 | 22,976 | Dave Roberts | Tom Underwood | John Sutton | Bruce Sutter | | 634 | 653 | -19 |
| 1977-09-13 | @ SLN | 144 | L 1-3 | 77-67 | 3 | 10,353 | Ray Burris | Bob Forsch | Bob Forsch | Ray Burris | Pete Falcone | 635 | 656 | -21 |
| 1977-09-14 | @ MON | 145 | L 2-3 | 77-68 | 3 | 5,235 | Mike Krukow | Hal Dues | Bill Atkinson | Dave Giusti | | 637 | 659 | -22 |
| 1977-09-15 | @ MON | 146 | L 4-5 | 77-69 | 3 | 7,369 | Bill Bonham | Wayne Twitchell | Will McEnaney | Bruce Sutter | | 641 | 664 | -23 |
| 1977-09-17 | @ NYN | 147 | L 4-5 | 78-70 | 3 | 0 | Dennis Lamp | Pat Zachry | Bob Apodaca | Paul Reuschel | | 645 | 669 | -24 |
| 1977-09-17 | @ NYN | 148 | W 4-3 | 78-70 | 3 | 5,963 | Dave Roberts | Roy Lee Jackson | Guillermo Hernandez | Skip Lockwood | | 649 | 672 | -23 |
| 1977-09-18 | @ NYN | 149 | W 6-3 | 79-71 | 3 | 0 | Rick Reuschel | Jackson Todd | Rick Reuschel | Jackson Todd | Bruce Sutter | 655 | 675 | -20 |
| 1977-09-18 | @ NYN | 150 | L 0-6 | 79-71 | 3 | 5,191 | Mike Krukow | Craig Swan | Craig Swan | Mike Krukow | Bob Myrick | 655 | 681 | -26 |
| 1977-09-20 | @ PHI | 151 | L 2-4 | 79-72 | 3 | 32,103 | Bill Bonham | Steve Carlton | Steve Carlton | Bill Bonham | | 657 | 685 | -28 |
| 1977-09-21 | @ PHI | 152 | W 2-0 | 80-72 | 3 | 31,512 | Ray Burris | Randy Lerch | Ray Burris | Randy Lerch | Bruce Sutter | 659 | 685 | -26 |
| 1977-09-22 | @ PHI | 153 | W 5-3 | 81-72 | 3 | 20,709 | Dennis Lamp | Jim Lonborg | Paul Reuschel | Jim Lonborg | Bruce Sutter | 664 | 688 | -24 |
| 1977-09-23 | vs PIT | 154 | L 0-2 | 81-73 | 3 | 3,757 | Mike Krukow | Jim Rooker | Jim Rooker | Guillermo Hernandez | Rich Gossage | 664 | 690 | -26 |
| 1977-09-24 | vs PIT | 155 | L 3-7 | 81-74 | 3 | 14,970 | Dave Roberts | Jerry Reuss | Terry Forster | Pete Broberg | Grant Jackson | 667 | 697 | -30 |
| 1977-09-25 | vs PIT | 156 | L 0-4 | 81-75 | 4 | 17,815 | Rick Reuschel | John Candelaria | John Candelaria | Rick Reuschel | | 667 | 701 | -34 |
| 1977-09-26 | vs PHI | 157 | W 10-7 | 82-75 | 3 | 3,679 | Ray Burris | Jim Lonborg | Donnie Moore | Jim Kaat | Bruce Sutter | 677 | 708 | -31 |
| 1977-09-27 | vs PHI | 158 | L 9-15 | 82-76 | 4 | 4,606 | Bill Bonham | Larry Christenson | Larry Christenson | Bill Bonham | | 686 | 723 | -37 |
| 1977-09-28 | vs PHI | 159 | L 2-5 | 82-77 | 4 | 5,116 | Mike Krukow | Manny Seoane | Randy Lerch | Mike Krukow | Warren Brusstar | 688 | 728 | -40 |
| 1977-09-30 | @ PIT | 160 | L 1-3 | 82-78 | 4 | 8,507 | Rick Reuschel | John Candelaria | John Candelaria | Rick Reuschel | | 689 | 731 | -42 |
| 1977-10-02 | @ PIT | 161 | L 1-5 | 82-80 | 4 | 0 | Ray Burris | Timothy Jones | Timothy Jones | Ray Burris | Grant Jackson | 690 | 736 | -46 |
| 1977-10-02 | @ PIT | 162 | L 2-3 | 82-80 | 4 | 20,418 | Bill Bonham | Ed Whitson | Rich Gossage | Dennis Lamp | | 692 | 739 | -47 |