| 1977-04-07 | vs CLE | 1 | L 4-5 | 0-1 | 5 | 34,790 | Fergie Jenkins | Dennis Eckersley | Dave LaRoche | Bill Campbell | | 4 | 5 | -1 |
| 1977-04-10 | vs CLE | 2 | L 9-19 | 0-2 | 6 | 14,931 | Reggie Cleveland | Al Fitzmorris | Dave LaRoche | Bill Campbell | | 13 | 24 | -11 |
| 1977-04-12 | @ CHA | 3 | L 2-5 | 0-3 | 7 | 34,612 | Rick Wise | Ken Brett | Ken Brett | Rick Wise | Dave Hamilton | 15 | 29 | -14 |
| 1977-04-13 | @ CHA | 4 | L 3-7 | 0-4 | 7 | 5,344 | Fergie Jenkins | Bart Johnson | Bart Johnson | Fergie Jenkins | Lerrin LaGrow | 18 | 36 | -18 |
| 1977-04-16 | @ CLE | 5 | W 8-4 | 1-4 | 7 | 51,165 | Luis Tiant | Wayne Garland | Luis Tiant | Wayne Garland | Bob Stanley | 26 | 40 | -14 |
| 1977-04-17 | @ CLE | 6 | W 4-1 | 2-5 | 6 | 0 | Reggie Cleveland | Al Fitzmorris | Reggie Cleveland | Al Fitzmorris | | 30 | 41 | -11 |
| 1977-04-17 | @ CLE | 7 | L 5-10 | 2-5 | 6 | 15,439 | Rick Wise | Jim Bibby | Jim Bibby | Tom Murphy | Dave LaRoche | 35 | 51 | -16 |
| 1977-04-18 | vs DET | 8 | W 5-3 | 3-5 | 5 | 30,059 | Fergie Jenkins | Bob Sykes | Fergie Jenkins | Fernando Arroyo | Jim Willoughby | 40 | 54 | -14 |
| 1977-04-19 | vs DET | 9 | W 11-3 | 4-5 | 4 | 16,941 | Bob Stanley | Ray Bare | Bob Stanley | Ray Bare | | 51 | 57 | -6 |
| 1977-04-20 | vs DET | 10 | L 2-3 | 4-6 | 4 | 20,289 | Luis Tiant | Vern Ruhle | Vern Ruhle | Luis Tiant | John Hiller | 53 | 60 | -7 |
| 1977-04-21 | vs DET | 11 | L 0-8 | 4-7 | 5 | 24,903 | Reggie Cleveland | Dave Rozema | Dave Rozema | Reggie Cleveland | | 53 | 68 | -15 |
| 1977-04-24 | @ TOR | 12 | W 9-0 | 5-7 | 5 | 29,303 | Fergie Jenkins | Bill Singer | Fergie Jenkins | Bill Singer | | 62 | 68 | -6 |
| 1977-04-25 | @ TOR | 13 | L 3-4 | 6-8 | 5 | 0 | Luis Tiant | Jerry Garvin | Pete Vuckovich | Bill Campbell | | 65 | 72 | -7 |
| 1977-04-25 | @ TOR | 14 | W 6-5 | 6-8 | 5 | 15,016 | Bob Stanley | Dave Lemanczyk | Jim Willoughby | Pete Vuckovich | | 71 | 77 | -6 |
| 1977-04-26 | @ MIL | 15 | W 3-1 | 7-8 | 5 | 12,676 | Rick Wise | Jerry Augustine | Rick Wise | Jerry Augustine | Bill Campbell | 74 | 78 | -4 |
| 1977-04-27 | @ MIL | 16 | L 2-4 | 7-9 | 5 | 10,646 | Reggie Cleveland | Moose Haas | Bill Castro | Reggie Cleveland | | 76 | 82 | -6 |
| 1977-04-29 | vs OAK | 17 | W 7-4 | 8-9 | 4 | 17,411 | Fergie Jenkins | Dock Ellis | Fergie Jenkins | Dock Ellis | Bill Campbell | 83 | 86 | -3 |
| 1977-04-30 | vs OAK | 18 | W 8-4 | 9-9 | 4 | 22,999 | Luis Tiant | Mike Norris | Luis Tiant | Mike Norris | | 91 | 90 | 1 |
| 1977-05-01 | vs OAK | 19 | W 6-4 | 10-9 | 4 | 22,053 | Bob Stanley | Vida Blue | Bill Campbell | Stan Bahnsen | | 97 | 94 | 3 |
| 1977-05-03 | vs SEA | 20 | L 8-10 | 10-10 | 4 | 12,422 | Rick Wise | Frank MacCormack | John Montague | Rick Wise | Dave Pagan | 105 | 104 | 1 |
| 1977-05-04 | vs SEA | 21 | W 5-2 | 11-10 | 4 | 11,408 | Reggie Cleveland | Stan Thomas | Reggie Cleveland | Stan Thomas | Bill Campbell | 110 | 106 | 4 |
| 1977-05-05 | vs SEA | 22 | W 5-2 | 12-10 | 4 | 10,358 | Fergie Jenkins | Diego Segui | Fergie Jenkins | Diego Segui | | 115 | 108 | 7 |
| 1977-05-06 | vs CAL | 23 | L 4-8 | 12-11 | 4 | 24,301 | Luis Tiant | Nolan Ryan | Nolan Ryan | Luis Tiant | Paul Hartzell | 119 | 116 | 3 |
| 1977-05-07 | vs CAL | 24 | W 3-0 | 13-11 | 4 | 28,426 | Bob Stanley | Frank Tanana | Bob Stanley | Frank Tanana | | 122 | 116 | 6 |
| 1977-05-08 | vs CAL | 25 | W 4-3 | 14-11 | 4 | 20,864 | Bill Lee | Gary Ross | Jim Willoughby | Gary Ross | | 126 | 119 | 7 |
| 1977-05-09 | @ OAK | 26 | L 1-2 | 14-12 | 4 | 17,290 | Reggie Cleveland | Vida Blue | Vida Blue | Reggie Cleveland | | 127 | 121 | 6 |
| 1977-05-11 | @ OAK | 27 | L 1-3 | 14-13 | 3 | 3,183 | Fergie Jenkins | Doc Medich | Doc Medich | Fergie Jenkins | | 128 | 124 | 4 |
| 1977-05-13 | @ SEA | 28 | W 7-5 | 15-13 | 3 | 20,523 | Luis Tiant | Dick Pole | Jim Willoughby | Enrique Romo | Bill Campbell | 135 | 129 | 6 |
| 1977-05-14 | @ SEA | 29 | W 8-4 | 16-13 | 3 | 52,485 | Bob Stanley | Stan Thomas | Bob Stanley | Stan Thomas | Bill Campbell | 143 | 133 | 10 |
| 1977-05-15 | @ SEA | 30 | W 5-4 | 17-13 | 3 | 47,353 | Bill Lee | Rick Jones | Bill Lee | Rick Jones | Bill Campbell | 148 | 137 | 11 |
| 1977-05-16 | @ CAL | 31 | W 8-7 | 18-13 | 2 | 11,714 | Reggie Cleveland | Gary Ross | Bill Campbell | Paul Hartzell | | 156 | 144 | 12 |
| 1977-05-17 | @ CAL | 32 | L 2-6 | 18-14 | 3 | 13,883 | Fergie Jenkins | Wayne Simpson | Wayne Simpson | Fergie Jenkins | Paul Hartzell | 158 | 150 | 8 |
| 1977-05-20 | vs MIL | 33 | L 7-15 | 18-15 | 3 | 25,991 | Luis Tiant | Jerry Augustine | Jerry Augustine | Luis Tiant | | 165 | 165 | 0 |
| 1977-05-21 | vs MIL | 34 | W 10-9 | 19-15 | 2 | 25,405 | Bob Stanley | Moose Haas | Tom House | Bill Castro | | 175 | 174 | 1 |
| 1977-05-22 | vs MIL | 35 | W 14-10 | 20-16 | 2 | 0 | Reggie Cleveland | Gary Beare | Bill Campbell | Rich Folkers | | 189 | 184 | 5 |
| 1977-05-22 | vs MIL | 36 | L 0-6 | 20-16 | 2 | 29,653 | Fergie Jenkins | Eduardo Rodriguez | Eduardo Rodriguez | Fergie Jenkins | | 189 | 190 | -1 |
| 1977-05-23 | @ NYA | 37 | W 4-3 | 21-16 | 2 | 31,261 | Bill Lee | Ed Figueroa | Bill Lee | Ed Figueroa | Bill Campbell | 193 | 193 | 0 |
| 1977-05-24 | @ NYA | 38 | L 5-6 | 21-17 | 2 | 27,013 | Luis Tiant | Ken Holtzman | Dick Tidrow | Luis Tiant | | 198 | 199 | -1 |
| 1977-05-25 | vs MIN | 39 | L 5-13 | 21-19 | 3 | 0 | Bob Stanley | Dave Goltz | Dave Goltz | Bob Stanley | Tom Burgmeier | 203 | 212 | -9 |
| 1977-05-25 | vs MIN | 40 | L 4-9 | 21-19 | 3 | 24,686 | Mike Paxton | Paul Thormodsgard | Paul Thormodsgard | Mike Paxton | | 207 | 221 | -14 |
| 1977-05-27 | vs KCA | 41 | W 10-1 | 22-19 | 3 | 23,472 | Fergie Jenkins | Dennis Leonard | Fergie Jenkins | Dennis Leonard | | 217 | 222 | -5 |
| 1977-05-28 | vs KCA | 42 | W 17-12 | 23-19 | 2 | 26,126 | Luis Tiant | Doug Bird | Bill Campbell | Marty Pattin | | 234 | 234 | 0 |
| 1977-05-29 | vs KCA | 43 | L 0-3 | 23-20 | 3 | 26,920 | Bob Stanley | Jim Colborn | Jim Colborn | Bob Stanley | Mark Littell | 234 | 237 | -3 |
| 1977-05-30 | vs NYA | 44 | L 4-5 | 23-21 | 3 | 35,521 | Bill Lee | Mike Torrez | Mike Torrez | Bill Lee | | 238 | 242 | -4 |
| 1977-05-31 | vs NYA | 45 | W 5-1 | 24-21 | 3 | 30,102 | Reggie Cleveland | Gil Patterson | Reggie Cleveland | Gil Patterson | | 243 | 243 | 0 |
| 1977-06-01 | @ TEX | 46 | W 7-5 | 25-21 | 2 | 11,731 | Luis Tiant | Doyle Alexander | Mike Paxton | Doyle Alexander | Bill Campbell | 250 | 248 | 2 |
| 1977-06-02 | @ TEX | 47 | L 1-3 | 25-22 | 3 | 12,158 | Fergie Jenkins | Nelson Briles | Darold Knowles | Fergie Jenkins | | 251 | 251 | 0 |
| 1977-06-03 | @ MIN | 48 | L 2-6 | 25-23 | 3 | 11,852 | Bob Stanley | Dave Goltz | Dave Goltz | Bob Stanley | | 253 | 257 | -4 |
| 1977-06-04 | @ MIN | 49 | W 5-2 | 26-23 | 3 | 15,290 | Bill Lee | Paul Thormodsgard | Bill Lee | Paul Thormodsgard | | 258 | 259 | -1 |
| 1977-06-05 | @ MIN | 50 | W 5-1 | 27-23 | 3 | 37,756 | Reggie Cleveland | Pete Redfern | Reggie Cleveland | Tom Burgmeier | Bill Campbell | 263 | 260 | 3 |
| 1977-06-06 | @ KCA | 51 | W 1-0 | 28-23 | 3 | 25,881 | Luis Tiant | Dennis Leonard | Luis Tiant | Dennis Leonard | Bill Campbell | 264 | 260 | 4 |
| 1977-06-07 | @ KCA | 52 | L 4-5 | 28-24 | 3 | 21,184 | Fergie Jenkins | Jim Colborn | Mark Littell | Mike Paxton | | 268 | 265 | 3 |
| 1977-06-08 | vs BAL | 53 | W 14-5 | 29-24 | 3 | 22,943 | Rick Wise | Dennis Martinez | Rick Wise | Dennis Martinez | | 282 | 270 | 12 |
| 1977-06-09 | vs BAL | 54 | W 7-3 | 30-24 | 2 | 24,064 | Bill Lee | Jim Palmer | Bill Lee | Jim Palmer | Bill Campbell | 289 | 273 | 16 |
| 1977-06-12 | vs TEX | 55 | W 3-2 | 32-24 | 2 | 0 | Reggie Cleveland | Doyle Alexander | Reggie Cleveland | Adrian Devine | | 292 | 275 | 17 |
| 1977-06-12 | vs TEX | 56 | W 2-0 | 32-24 | 2 | 31,038 | Luis Tiant | Nelson Briles | Luis Tiant | Nelson Briles | | 294 | 275 | 19 |
| 1977-06-13 | vs CHA | 57 | W 5-4 | 33-24 | 1 | 23,114 | Fergie Jenkins | Francisco Barrios | Bill Campbell | Larry Anderson | | 299 | 279 | 20 |
| 1977-06-14 | vs CHA | 58 | W 7-1 | 34-24 | 1 | 27,147 | Rick Wise | Chris Knapp | Rick Wise | Chris Knapp | Bill Campbell | 306 | 280 | 26 |
| 1977-06-16 | vs CHA | 59 | L 3-7 | 34-25 | 2 | 32,031 | Luis Tiant | Steve Stone | Steve Stone | Luis Tiant | Lerrin LaGrow | 309 | 287 | 22 |
| 1977-06-17 | vs NYA | 60 | W 9-4 | 35-25 | 1 | 34,557 | Bill Lee | Catfish Hunter | Bob Stanley | Ken Clay | Bill Campbell | 318 | 291 | 27 |
| 1977-06-18 | vs NYA | 61 | W 10-4 | 36-25 | 1 | 34,603 | Reggie Cleveland | Mike Torrez | Reggie Cleveland | Mike Torrez | Bill Campbell | 328 | 295 | 33 |
| 1977-06-19 | vs NYA | 62 | W 11-1 | 37-25 | 1 | 34,750 | Fergie Jenkins | Ed Figueroa | Fergie Jenkins | Ed Figueroa | | 339 | 296 | 43 |
| 1977-06-20 | @ BAL | 63 | W 4-0 | 38-25 | 1 | 23,815 | Rick Wise | Rudy May | Rick Wise | Rudy May | | 343 | 296 | 47 |
| 1977-06-21 | @ BAL | 64 | W 7-0 | 39-25 | 1 | 24,174 | Luis Tiant | Dennis Martinez | Luis Tiant | Dennis Martinez | | 350 | 296 | 54 |
| 1977-06-22 | @ BAL | 65 | W 7-4 | 40-25 | 1 | 27,134 | Reggie Cleveland | Jim Palmer | Mike Paxton | Jim Palmer | Bill Campbell | 357 | 300 | 57 |
| 1977-06-23 | @ BAL | 66 | W 7-3 | 41-25 | 1 | 27,810 | Fergie Jenkins | Mike Flanagan | Fergie Jenkins | Mike Flanagan | | 364 | 303 | 61 |
| 1977-06-24 | @ NYA | 67 | L 5-6 | 41-26 | 1 | 54,940 | Bill Lee | Catfish Hunter | Sparky Lyle | Ramon Hernandez | | 369 | 309 | 60 |
| 1977-06-25 | @ NYA | 68 | L 1-5 | 41-27 | 1 | 47,481 | Luis Tiant | Mike Torrez | Mike Torrez | Luis Tiant | | 370 | 314 | 56 |
| 1977-06-26 | @ NYA | 69 | L 4-5 | 41-28 | 1 | 55,039 | Reggie Cleveland | Don Gullett | Sparky Lyle | Bill Campbell | | 374 | 319 | 55 |
| 1977-06-27 | @ DET | 70 | L 1-4 | 41-29 | 1 | 14,433 | Rick Wise | Dave Roberts | Dave Roberts | Rick Wise | | 375 | 323 | 52 |
| 1977-06-28 | @ DET | 71 | L 2-3 | 41-30 | 1 | 13,403 | Fergie Jenkins | Fernando Arroyo | Jim Crawford | Bill Campbell | | 377 | 326 | 51 |
| 1977-06-29 | @ DET | 72 | L 2-7 | 41-31 | 1 | 51,745 | Bill Lee | Mark Fidrych | Mark Fidrych | Bill Lee | | 379 | 333 | 46 |
| 1977-07-01 | vs BAL | 73 | L 2-8 | 41-32 | 1 | 33,481 | Luis Tiant | Jim Palmer | Jim Palmer | Luis Tiant | | 381 | 341 | 40 |
| 1977-07-02 | vs BAL | 74 | L 2-5 | 41-33 | 2 | 32,987 | Reggie Cleveland | Mike Flanagan | Mike Flanagan | Reggie Cleveland | | 383 | 346 | 37 |
| 1977-07-03 | vs BAL | 75 | L 8-12 | 41-34 | 2 | 31,081 | Rick Wise | Dennis Martinez | Dennis Martinez | Rick Wise | Dick Drago | 391 | 358 | 33 |
| 1977-07-04 | vs TOR | 76 | W 9-6 | 42-34 | 2 | 21,073 | Fergie Jenkins | Jerry Garvin | Bill Campbell | Chuck Hartenstein | | 400 | 364 | 36 |
| 1977-07-06 | vs TOR | 77 | W 9-5 | 43-34 | 3 | 34,956 | Luis Tiant | Pete Vuckovich | Bill Campbell | Pete Vuckovich | | 409 | 369 | 40 |
| 1977-07-07 | vs TOR | 78 | W 5-2 | 44-34 | 2 | 32,641 | Bob Stanley | Jesse Jefferson | Bob Stanley | Jesse Jefferson | Bill Campbell | 414 | 371 | 43 |
| 1977-07-08 | @ MIL | 79 | W 7-3 | 45-34 | 2 | 31,663 | Reggie Cleveland | Jim Slaton | Reggie Cleveland | Jim Slaton | | 421 | 374 | 47 |
| 1977-07-09 | @ MIL | 80 | L 2-3 | 45-35 | 2 | 25,372 | Fergie Jenkins | Jerry Augustine | Jerry Augustine | Fergie Jenkins | Bill Castro | 423 | 377 | 46 |
| 1977-07-10 | @ MIL | 81 | W 8-5 | 47-35 | 1 | 0 | Luis Tiant | Lary Sorensen | Bill Campbell | Eduardo Rodriguez | | 431 | 382 | 49 |
| 1977-07-10 | @ MIL | 82 | W 7-3 | 47-35 | 1 | 28,887 | Rick Wise | Mike Caldwell | Rick Wise | Mike Caldwell | | 438 | 385 | 53 |
| 1977-07-11 | @ CLE | 83 | W 2-1 | 48-35 | 1 | 12,573 | Bob Stanley | Jim Bibby | Bob Stanley | Jim Bibby | | 440 | 386 | 54 |
| 1977-07-12 | @ CLE | 84 | L 1-7 | 48-36 | 1 | 14,425 | Reggie Cleveland | Dennis Eckersley | Dennis Eckersley | Reggie Cleveland | | 441 | 393 | 48 |
| 1977-07-13 | @ CLE | 85 | W 9-7 | 49-36 | 1 | 18,524 | Fergie Jenkins | Wayne Garland | Bill Campbell | Jim Kern | Bill Lee | 450 | 400 | 50 |
| 1977-07-14 | @ CLE | 86 | W 7-4 | 50-36 | 1 | 15,451 | Luis Tiant | Al Fitzmorris | Mike Paxton | Al Fitzmorris | Ramon Hernandez | 457 | 404 | 53 |
| 1977-07-15 | @ CHA | 87 | L 7-9 | 50-37 | 2 | 41,597 | Bob Stanley | Wilbur Wood | Wilbur Wood | Bob Stanley | Lerrin LaGrow | 464 | 413 | 51 |
| 1977-07-16 | @ CHA | 88 | W 4-3 | 51-37 | 2 | 36,007 | Rick Wise | Francisco Barrios | Rick Wise | Francisco Barrios | Bill Campbell | 468 | 416 | 52 |
| 1977-07-17 | @ CHA | 89 | L 2-3 | 51-38 | 2 | 27,235 | Reggie Cleveland | Steve Stone | Steve Stone | Reggie Cleveland | Lerrin LaGrow | 470 | 419 | 51 |
| 1977-07-21 | vs CLE | 90 | W 11-4 | 52-39 | 2 | 20,173 | Luis Tiant | Wayne Garland | Luis Tiant | Wayne Garland | | 481 | 423 | 58 |
| 1977-07-21 | vs CLE | 91 | L 2-8 | 52-39 | 2 | 29,059 | Bob Stanley | Jim Bibby | Jim Bibby | Bob Stanley | Jim Kern | 483 | 431 | 52 |
| 1977-07-22 | vs CLE | 92 | W 3-0 | 53-39 | 1 | 34,030 | Rick Wise | Al Fitzmorris | Rick Wise | Al Fitzmorris | | 486 | 431 | 55 |
| 1977-07-23 | vs CLE | 93 | L 8-9 | 53-40 | 1 | 35,592 | Reggie Cleveland | Dennis Eckersley | Jim Kern | Bill Campbell | | 494 | 440 | 54 |
| 1977-07-24 | vs CHA | 94 | L 6-9 | 53-41 | 2 | 34,490 | Fergie Jenkins | Francisco Barrios | Francisco Barrios | Fergie Jenkins | | 500 | 449 | 51 |
| 1977-07-25 | vs CHA | 95 | L 7-8 | 53-42 | 2 | 27,505 | Luis Tiant | Steve Stone | Lerrin LaGrow | Bill Campbell | | 507 | 457 | 50 |
| 1977-07-26 | vs MIL | 96 | W 4-3 | 54-42 | 2 | 30,950 | Don Aase | Lary Sorensen | Don Aase | Lary Sorensen | | 511 | 460 | 51 |
| 1977-07-27 | vs MIL | 97 | L 5-14 | 54-43 | 2 | 31,417 | Rick Wise | Mike Caldwell | Bob McClure | Bob Stanley | | 516 | 474 | 42 |
| 1977-07-28 | vs MIL | 98 | W 12-0 | 55-43 | 2 | 34,705 | Mike Paxton | Sam Hinds | Mike Paxton | Sam Hinds | | 528 | 474 | 54 |
| 1977-07-29 | @ CAL | 99 | W 6-5 | 56-43 | 2 | 23,542 | Fergie Jenkins | Paul Hartzell | Bill Campbell | Dyar Miller | | 534 | 479 | 55 |
| 1977-07-30 | @ CAL | 100 | W 3-0 | 57-43 | 2 | 32,662 | Luis Tiant | Nolan Ryan | Luis Tiant | Nolan Ryan | Bob Stanley | 537 | 479 | 58 |
| 1977-07-31 | @ CAL | 101 | W 1-0 | 58-43 | 1 | 19,514 | Don Aase | Frank Tanana | Don Aase | Dave LaRoche | | 538 | 479 | 59 |
| 1977-08-02 | @ SEA | 102 | W 3-2 | 59-43 | 1 | 24,344 | Rick Wise | Tom House | Bill Campbell | John Montague | | 541 | 481 | 60 |
| 1977-08-03 | @ SEA | 103 | W 12-4 | 60-43 | 1 | 21,152 | Mike Paxton | Gary Wheelock | Mike Paxton | Gary Wheelock | | 553 | 485 | 68 |
| 1977-08-04 | @ OAK | 104 | W 3-1 | 61-43 | 1 | 13,326 | Fergie Jenkins | Vida Blue | Fergie Jenkins | Vida Blue | | 556 | 486 | 70 |
| 1977-08-05 | @ OAK | 105 | W 1-0 | 62-43 | 1 | 7,163 | Luis Tiant | Joe Coleman | Luis Tiant | Joe Coleman | | 557 | 486 | 71 |
| 1977-08-06 | @ OAK | 106 | W 2-1 | 63-43 | 1 | 6,331 | Don Aase | Pablo Torrealba | Don Aase | Pablo Torrealba | Bill Campbell | 559 | 487 | 72 |
| 1977-08-07 | @ OAK | 107 | W 5-2 | 64-43 | 1 | 7,586 | Rick Wise | Rick Langford | Rick Wise | Rick Langford | Bill Campbell | 564 | 489 | 75 |
| 1977-08-10 | vs CAL | 108 | W 11-10 | 65-43 | 1 | 34,869 | Luis Tiant | Frank Tanana | Jim Willoughby | Dyar Miller | | 575 | 499 | 76 |
| 1977-08-11 | vs CAL | 109 | L 3-7 | 65-44 | 1 | 35,691 | Don Aase | Paul Hartzell | Paul Hartzell | Don Aase | | 578 | 506 | 72 |
| 1977-08-12 | vs SEA | 110 | W 7-2 | 66-44 | 1 | 27,005 | Rick Wise | Paul Mitchell | Rick Wise | Paul Mitchell | | 585 | 508 | 77 |
| 1977-08-13 | vs SEA | 111 | W 13-6 | 67-44 | 1 | 34,095 | Fergie Jenkins | Bob Galasso | Fergie Jenkins | Bob Galasso | | 598 | 514 | 84 |
| 1977-08-14 | vs SEA | 112 | W 11-1 | 68-44 | 1 | 31,223 | Mike Paxton | Gary Wheelock | Mike Paxton | Gary Wheelock | | 609 | 515 | 94 |
| 1977-08-15 | vs KCA | 113 | W 2-1 | 69-44 | 1 | 33,424 | Reggie Cleveland | Jim Colborn | Reggie Cleveland | Jim Colborn | Bill Campbell | 611 | 516 | 95 |
| 1977-08-16 | vs KCA | 114 | W 5-3 | 70-44 | 1 | 35,748 | Don Aase | Mark Littell | Bill Campbell | Doug Bird | | 616 | 519 | 97 |
| 1977-08-17 | @ MIL | 115 | L 3-5 | 70-45 | 1 | 13,692 | Rick Wise | Lary Sorensen | Lary Sorensen | Rick Wise | | 619 | 524 | 95 |
| 1977-08-18 | @ MIL | 116 | W 8-4 | 71-45 | 1 | 15,862 | Fergie Jenkins | Mike Caldwell | Fergie Jenkins | Mike Caldwell | | 627 | 528 | 99 |
| 1977-08-19 | @ KCA | 117 | L 3-9 | 71-46 | 1 | 36,725 | Mike Paxton | Jim Colborn | Jim Colborn | Mike Paxton | | 630 | 537 | 93 |
| 1977-08-20 | @ KCA | 118 | L 2-5 | 71-47 | 1 | 40,502 | Luis Tiant | Mark Littell | Mark Littell | Luis Tiant | Doug Bird | 632 | 542 | 90 |
| 1977-08-21 | @ KCA | 119 | L 4-6 | 71-48 | 1 | 31,199 | Don Aase | Paul Splittorff | Doug Bird | Bill Campbell | | 636 | 548 | 88 |
| 1977-08-22 | @ MIN | 120 | L 4-5 | 71-49 | 1 | 22,805 | Rick Wise | Paul Thormodsgard | Tom Johnson | Bill Lee | | 640 | 553 | 87 |
| 1977-08-23 | @ MIN | 121 | L 0-7 | 71-50 | 2 | 32,346 | Fergie Jenkins | Dave Goltz | Dave Goltz | Fergie Jenkins | | 640 | 560 | 80 |
| 1977-08-24 | vs TEX | 122 | L 0-3 | 71-52 | 3 | 0 | Mike Paxton | Gaylord Perry | Gaylord Perry | Mike Paxton | Adrian Devine | 640 | 563 | 77 |
| 1977-08-24 | vs TEX | 123 | L 3-6 | 71-52 | 3 | 31,784 | Reggie Cleveland | Nelson Briles | Len Barker | Reggie Cleveland | | 643 | 569 | 74 |
| 1977-08-25 | vs TEX | 124 | W 9-6 | 72-52 | 2 | 30,186 | Luis Tiant | Doyle Alexander | Jim Willoughby | Darold Knowles | Bill Campbell | 652 | 575 | 77 |
| 1977-08-26 | vs MIN | 125 | L 4-6 | 72-53 | 2 | 33,415 | Don Aase | Paul Thormodsgard | Tom Johnson | Rick Kreuger | | 656 | 581 | 75 |
| 1977-08-27 | vs MIN | 126 | W 7-5 | 73-53 | 2 | 34,636 | Bill Lee | Dave Johnson | Bill Lee | Ron Schueler | Jim Willoughby | 663 | 586 | 77 |
| 1977-08-28 | vs MIN | 127 | W 6-5 | 74-53 | 2 | 31,619 | Fergie Jenkins | Dave Goltz | Mike Paxton | Ron Schueler | Bill Campbell | 669 | 591 | 78 |
| 1977-08-29 | vs OAK | 128 | L 7-8 | 74-54 | 2 | 29,750 | Rick Wise | Joe Coleman | Doug Bair | Bill Campbell | | 676 | 599 | 77 |
| 1977-08-30 | vs OAK | 129 | W 7-2 | 75-54 | 2 | 27,264 | Luis Tiant | Rick Langford | Luis Tiant | Rick Langford | Reggie Cleveland | 683 | 601 | 82 |
| 1977-08-31 | vs CLE | 130 | L 3-4 | 75-55 | 3 | 29,226 | Don Aase | Al Fitzmorris | Jim Kern | Bob Stanley | | 686 | 605 | 81 |
| 1977-09-01 | vs CLE | 131 | W 3-1 | 76-55 | 2 | 31,736 | Bill Lee | Dennis Eckersley | Bill Lee | Dennis Eckersley | Reggie Cleveland | 689 | 606 | 83 |
| 1977-09-02 | @ TEX | 132 | L 4-6 | 76-56 | 3 | 18,883 | Fergie Jenkins | Bert Blyleven | Bert Blyleven | Fergie Jenkins | Roger Moret | 693 | 612 | 81 |
| 1977-09-03 | @ TEX | 133 | W 2-1 | 77-56 | 2 | 36,852 | Mike Paxton | Dock Ellis | Mike Paxton | Dock Ellis | Bill Campbell | 695 | 613 | 82 |
| 1977-09-04 | @ TEX | 134 | W 8-4 | 78-56 | 2 | 27,794 | Luis Tiant | Gaylord Perry | Rick Wise | Gaylord Perry | Bill Campbell | 703 | 617 | 86 |
| 1977-09-05 | @ TOR | 135 | W 8-0 | 80-56 | 2 | 0 | Don Aase | Jeff Byrd | Don Aase | Jeff Byrd | | 711 | 617 | 94 |
| 1977-09-05 | @ TOR | 136 | W 6-0 | 80-56 | 2 | 30,373 | Reggie Cleveland | Jim Clancy | Reggie Cleveland | Jim Clancy | | 717 | 617 | 100 |
| 1977-09-06 | @ TOR | 137 | W 11-2 | 81-56 | 2 | 17,666 | Bill Lee | Mike Darr | Bill Lee | Mike Darr | | 728 | 619 | 109 |
| 1977-09-07 | @ TOR | 138 | L 2-3 | 81-57 | 2 | 31,684 | Fergie Jenkins | Dave Lemanczyk | Dave Lemanczyk | Fergie Jenkins | | 730 | 622 | 108 |
| 1977-09-08 | @ TOR | 139 | W 7-2 | 82-57 | 2 | 19,163 | Mike Paxton | Jesse Jefferson | Mike Paxton | Jesse Jefferson | | 737 | 624 | 113 |
| 1977-09-09 | vs DET | 140 | W 5-1 | 84-57 | 2 | 0 | Luis Tiant | Dave Rozema | Luis Tiant | Dave Rozema | Bill Campbell | 742 | 625 | 117 |
| 1977-09-09 | vs DET | 141 | W 8-6 | 84-57 | 2 | 34,581 | Reggie Cleveland | Steve Grilli | Rick Wise | Vern Ruhle | Bill Campbell | 750 | 631 | 119 |
| 1977-09-10 | vs DET | 142 | W 7-1 | 85-57 | 2 | 26,782 | Don Aase | Milt Wilcox | Don Aase | Milt Wilcox | | 757 | 632 | 125 |
| 1977-09-11 | vs DET | 143 | W 6-2 | 86-57 | 2 | 34,325 | Bill Lee | Fernando Arroyo | Bill Lee | Fernando Arroyo | | 763 | 634 | 129 |
| 1977-09-13 | @ NYA | 144 | L 2-4 | 86-58 | 2 | 55,269 | Mike Paxton | Ron Guidry | Ron Guidry | Mike Paxton | | 765 | 638 | 127 |
| 1977-09-14 | @ NYA | 145 | L 0-2 | 86-59 | 3 | 54,365 | Reggie Cleveland | Ed Figueroa | Ed Figueroa | Reggie Cleveland | | 765 | 640 | 125 |
| 1977-09-15 | @ NYA | 146 | W 7-3 | 87-59 | 3 | 55,218 | Luis Tiant | Mike Torrez | Luis Tiant | Sparky Lyle | | 772 | 643 | 129 |
| 1977-09-16 | @ BAL | 147 | L 1-6 | 87-60 | 3 | 29,736 | Don Aase | Jim Palmer | Jim Palmer | Don Aase | | 773 | 649 | 124 |
| 1977-09-17 | @ BAL | 148 | L 2-11 | 87-61 | 3 | 26,324 | Bill Lee | Dennis Martinez | Dennis Martinez | Bill Lee | | 775 | 660 | 115 |
| 1977-09-18 | @ BAL | 149 | W 10-4 | 88-61 | 3 | 51,798 | Mike Paxton | Mike Flanagan | Bob Stanley | Scott McGregor | Bill Campbell | 785 | 664 | 121 |
| 1977-09-19 | vs NYA | 150 | W 6-3 | 89-61 | 3 | 34,346 | Reggie Cleveland | Ed Figueroa | Reggie Cleveland | Ed Figueroa | | 791 | 667 | 124 |
| 1977-09-21 | vs NYA | 151 | W 3-2 | 90-61 | 3 | 30,212 | Luis Tiant | Mike Torrez | Jim Willoughby | Mike Torrez | Bill Campbell | 794 | 669 | 125 |
| 1977-09-22 | @ DET | 152 | L 4-5 | 90-62 | 3 | 3,507 | Don Aase | Fernando Arroyo | Fernando Arroyo | Jim Willoughby | Steve Foucault | 798 | 674 | 124 |
| 1977-09-23 | @ DET | 153 | W 5-1 | 91-62 | 3 | 11,344 | Bill Lee | Bob Sykes | Bill Lee | Bob Sykes | | 803 | 675 | 128 |
| 1977-09-24 | @ DET | 154 | W 6-2 | 92-62 | 3 | 9,245 | Mike Paxton | Milt Wilcox | Mike Paxton | Milt Wilcox | Bill Campbell | 809 | 677 | 132 |
| 1977-09-25 | @ DET | 155 | W 12-5 | 93-62 | 2 | 12,707 | Reggie Cleveland | Ed Glynn | Reggie Cleveland | Ed Glynn | | 821 | 682 | 139 |
| 1977-09-27 | vs TOR | 156 | W 6-5 | 95-62 | 2 | 0 | Don Aase | Jeff Byrd | Don Aase | Jeff Byrd | Bill Campbell | 827 | 687 | 140 |
| 1977-09-27 | vs TOR | 157 | W 5-1 | 95-62 | 2 | 23,952 | Luis Tiant | Dave Lemanczyk | Luis Tiant | Dave Lemanczyk | Bill Campbell | 832 | 688 | 144 |
| 1977-09-28 | vs TOR | 158 | L 2-3 | 95-63 | 3 | 20,362 | Bill Lee | Jesse Jefferson | Pete Vuckovich | Bill Lee | | 834 | 691 | 143 |
| 1977-09-29 | vs TOR | 159 | W 7-3 | 96-63 | 3 | 12,240 | Mike Paxton | Jerry Garvin | Bob Stanley | Jerry Garvin | | 841 | 694 | 147 |
| 1977-09-30 | vs BAL | 160 | W 11-10 | 97-63 | 2 | 28,553 | Reggie Cleveland | Dennis Martinez | Bill Campbell | Scott McGregor | Bob Stanley | 852 | 704 | 148 |
| 1977-10-01 | vs BAL | 161 | L 7-8 | 97-64 | 3 | 29,107 | Rick Wise | Mike Flanagan | Mike Flanagan | Jim Willoughby | Nelson Briles | 859 | 712 | 147 |