| 1977-04-07 | vs TEX | 1 | L 1-2 | 0-1 | 4 | 31,307 | Jim Palmer | Bert Blyleven | Bert Blyleven | Jim Palmer | | 1 | 2 | -1 |
| 1977-04-09 | vs TEX | 2 | L 1-5 | 0-2 | 5 | 5,305 | Rudy May | Gaylord Perry | Gaylord Perry | Rudy May | | 2 | 7 | -5 |
| 1977-04-10 | vs TEX | 3 | L 2-3 | 0-3 | 5 | 5,495 | Ross Grimsley | Doyle Alexander | Doyle Alexander | Ross Grimsley | Paul Lindblad | 4 | 10 | -6 |
| 1977-04-12 | @ MIL | 4 | W 1-0 | 1-3 | 4 | 55,120 | Jim Palmer | Bill Travers | Jim Palmer | Bill Travers | | 5 | 10 | -5 |
| 1977-04-14 | @ MIL | 5 | L 0-5 | 1-4 | 5 | 5,727 | Rudy May | Jim Slaton | Jim Slaton | Rudy May | | 5 | 15 | -10 |
| 1977-04-17 | @ TEX | 6 | W 5-0 | 3-4 | 4 | 24,241 | Jim Palmer | Bert Blyleven | Jim Palmer | Bert Blyleven | | 10 | 15 | -5 |
| 1977-04-17 | @ TEX | 7 | W 6-1 | 3-4 | 4 | 24,241 | Ross Grimsley | Gaylord Perry | Ross Grimsley | Gaylord Perry | | 16 | 16 | 0 |
| 1977-04-18 | vs CLE | 8 | W 4-3 | 4-4 | 3 | 6,466 | Rudy May | Pat Dobson | Rudy May | Pat Dobson | Dyar Miller | 20 | 19 | 1 |
| 1977-04-19 | vs CLE | 9 | W 6-5 | 5-4 | 3 | 4,826 | Mike Flanagan | Dennis Eckersley | Dyar Miller | Dave LaRoche | | 26 | 24 | 2 |
| 1977-04-20 | vs CLE | 10 | W 7-2 | 6-4 | 2 | 6,439 | Scott McGregor | Wayne Garland | Scott McGregor | Wayne Garland | | 33 | 26 | 7 |
| 1977-04-24 | @ DET | 11 | W 3-1 | 7-5 | 2 | 17,115 | Jim Palmer | Dave Roberts | Jim Palmer | Dave Roberts | | 36 | 27 | 9 |
| 1977-04-24 | @ DET | 12 | L 1-2 | 7-5 | 2 | 17,115 | Mike Flanagan | Vern Ruhle | Vern Ruhle | Mike Flanagan | John Hiller | 37 | 29 | 8 |
| 1977-04-25 | vs NYA | 13 | L 6-9 | 7-6 | 2 | 17,624 | Ross Grimsley | Don Gullett | Dick Tidrow | Dennis Martinez | Sparky Lyle | 43 | 38 | 5 |
| 1977-04-26 | vs NYA | 14 | W 6-2 | 8-6 | 2 | 12,884 | Rudy May | Ken Holtzman | Rudy May | Ken Holtzman | | 49 | 40 | 9 |
| 1977-04-27 | vs NYA | 15 | L 3-4 | 8-7 | 2 | 15,647 | Scott McGregor | Gil Patterson | Sparky Lyle | Dennis Martinez | | 52 | 44 | 8 |
| 1977-04-29 | vs CAL | 16 | L 2-3 | 8-8 | 3 | 8,155 | Jim Palmer | Frank Tanana | Frank Tanana | Dyar Miller | | 54 | 47 | 7 |
| 1977-04-30 | vs CAL | 17 | W 4-3 | 9-8 | 3 | 9,138 | Mike Flanagan | Nolan Ryan | Dennis Martinez | Nolan Ryan | | 58 | 50 | 8 |
| 1977-05-01 | vs CAL | 18 | W 3-2 | 10-8 | 3 | 9,061 | Ross Grimsley | Gary Ross | Ross Grimsley | Paul Hartzell | | 61 | 52 | 9 |
| 1977-05-02 | vs OAK | 19 | L 0-2 | 10-9 | 3 | 4,407 | Rudy May | Rick Langford | Rick Langford | Rudy May | Dave Giusti | 61 | 54 | 7 |
| 1977-05-04 | vs OAK | 20 | W 9-2 | 11-9 | 3 | 3,232 | Jim Palmer | Dock Ellis | Jim Palmer | Dock Ellis | | 70 | 56 | 14 |
| 1977-05-06 | vs SEA | 21 | W 4-1 | 12-9 | 3 | 4,402 | Ross Grimsley | Glenn Abbott | Ross Grimsley | Glenn Abbott | | 74 | 57 | 17 |
| 1977-05-07 | vs SEA | 22 | W 4-2 | 13-9 | 2 | 16,212 | Rudy May | Rick Jones | Rudy May | Rick Jones | Mike Flanagan | 78 | 59 | 19 |
| 1977-05-08 | vs SEA | 23 | W 6-4 | 14-9 | 2 | 9,638 | Jim Palmer | Dick Pole | Jim Palmer | Dick Pole | Scott McGregor | 84 | 63 | 21 |
| 1977-05-11 | @ CAL | 24 | L 0-6 | 14-10 | 2 | 11,025 | Ross Grimsley | Frank Tanana | Frank Tanana | Ross Grimsley | | 84 | 69 | 15 |
| 1977-05-12 | @ CAL | 25 | L 5-7 | 14-11 | 2 | 10,208 | Jim Palmer | Gary Ross | Don Kirkwood | Jim Palmer | Dave LaRoche | 89 | 76 | 13 |
| 1977-05-13 | @ OAK | 26 | W 5-1 | 15-11 | 2 | 4,115 | Rudy May | Vida Blue | Rudy May | Vida Blue | | 94 | 77 | 17 |
| 1977-05-14 | @ OAK | 27 | W 2-0 | 16-11 | 2 | 4,216 | Mike Flanagan | Rick Langford | Mike Flanagan | Rick Langford | | 96 | 77 | 19 |
| 1977-05-15 | @ OAK | 28 | W 3-2 | 17-11 | 1 | 5,419 | Ross Grimsley | Stan Bahnsen | Ross Grimsley | Stan Bahnsen | Dennis Martinez | 99 | 79 | 20 |
| 1977-05-16 | @ SEA | 29 | L 3-8 | 17-12 | 1 | 10,388 | Jim Palmer | Glenn Abbott | Glenn Abbott | Jim Palmer | Mike Kekich | 102 | 87 | 15 |
| 1977-05-17 | @ SEA | 30 | L 2-10 | 17-13 | 2 | 10,920 | Rudy May | Dick Pole | Enrique Romo | Rudy May | | 104 | 97 | 7 |
| 1977-05-19 | @ NYA | 31 | L 1-9 | 17-14 | 3 | 15,909 | Mike Flanagan | Ed Figueroa | Ed Figueroa | Mike Flanagan | | 105 | 106 | -1 |
| 1977-05-20 | @ NYA | 32 | W 6-5 | 18-14 | 2 | 25,872 | Jim Palmer | Don Gullett | Dennis Martinez | Dick Tidrow | | 111 | 111 | 0 |
| 1977-05-21 | @ NYA | 33 | W 4-3 | 19-14 | 1 | 19,968 | Ross Grimsley | Mike Torrez | Tippy Martinez | Sparky Lyle | | 115 | 114 | 1 |
| 1977-05-22 | @ NYA | 34 | W 5-1 | 20-15 | 1 | 43,285 | Rudy May | Catfish Hunter | Rudy May | Catfish Hunter | | 120 | 115 | 5 |
| 1977-05-22 | @ NYA | 35 | L 2-8 | 20-15 | 1 | 43,285 | Scott McGregor | Ron Guidry | Ron Guidry | Scott McGregor | | 122 | 123 | -1 |
| 1977-05-23 | vs MIL | 36 | W 6-5 | 21-15 | 1 | 12,009 | Mike Flanagan | Jim Slaton | Dyar Miller | Jim Slaton | | 128 | 128 | 0 |
| 1977-05-24 | vs MIL | 37 | W 2-1 | 22-15 | 1 | 5,224 | Jim Palmer | Jerry Augustine | Jim Palmer | Jerry Augustine | | 130 | 129 | 1 |
| 1977-05-25 | vs KCA | 38 | L 1-4 | 23-16 | 1 | 11,388 | Ross Grimsley | Paul Splittorff | Paul Splittorff | Ross Grimsley | Larry Gura | 131 | 133 | -2 |
| 1977-05-25 | vs KCA | 39 | W 7-2 | 23-16 | 1 | 11,388 | Dennis Martinez | Jim Colborn | Dennis Martinez | Jim Colborn | | 138 | 135 | 3 |
| 1977-05-27 | vs MIN | 40 | W 6-0 | 24-16 | 1 | 12,219 | Rudy May | Geoff Zahn | Rudy May | Geoff Zahn | | 144 | 135 | 9 |
| 1977-05-28 | vs MIN | 41 | W 3-1 | 25-16 | 1 | 47,360 | Jim Palmer | Jeff Holly | Jim Palmer | Jeff Holly | | 147 | 136 | 11 |
| 1977-05-29 | vs MIN | 42 | L 2-3 | 25-17 | 1 | 15,083 | Mike Flanagan | Dave Goltz | Dave Goltz | Mike Flanagan | Tom Johnson | 149 | 139 | 10 |
| 1977-05-30 | @ MIN | 43 | W 9-7 | 26-17 | 1 | 16,065 | Ross Grimsley | Paul Thormodsgard | Ross Grimsley | Ron Schueler | Scott McGregor | 158 | 146 | 12 |
| 1977-05-31 | @ MIN | 44 | L 3-8 | 26-18 | 1 | 4,535 | Rudy May | Pete Redfern | Pete Redfern | Rudy May | | 161 | 154 | 7 |
| 1977-06-01 | @ CHA | 45 | L 2-4 | 26-19 | 1 | 9,784 | Jim Palmer | Ken Brett | Ken Brett | Jim Palmer | | 163 | 158 | 5 |
| 1977-06-02 | @ CHA | 46 | L 4-7 | 26-20 | 1 | 8,331 | Mike Flanagan | Francisco Barrios | Francisco Barrios | Mike Flanagan | Dave Hamilton | 167 | 165 | 2 |
| 1977-06-03 | @ KCA | 47 | W 7-6 | 27-20 | 1 | 21,878 | Ross Grimsley | Doug Bird | Ross Grimsley | Doug Bird | Tippy Martinez | 174 | 171 | 3 |
| 1977-06-04 | @ KCA | 48 | W 5-4 | 28-21 | 1 | 36,931 | Dennis Martinez | Jim Colborn | Dennis Martinez | Jim Colborn | | 179 | 175 | 4 |
| 1977-06-04 | @ KCA | 49 | L 13-14 | 28-21 | 1 | 36,931 | Rudy May | Paul Splittorff | Larry Gura | Mike Flanagan | | 192 | 189 | 3 |
| 1977-06-05 | @ KCA | 50 | L 3-4 | 28-22 | 1 | 16,559 | Jim Palmer | Andy Hassler | Andy Hassler | Jim Palmer | Larry Gura | 195 | 193 | 2 |
| 1977-06-06 | @ MIL | 51 | W 5-2 | 29-22 | 1 | 7,682 | Rudy May | Eduardo Rodriguez | Rudy May | Eduardo Rodriguez | | 200 | 195 | 5 |
| 1977-06-07 | @ MIL | 52 | L 6-7 | 29-23 | 1 | 9,190 | Ross Grimsley | Lary Sorensen | Bill Castro | Dyar Miller | | 206 | 202 | 4 |
| 1977-06-08 | @ BOS | 53 | L 5-14 | 29-24 | 2 | 22,943 | Dennis Martinez | Rick Wise | Rick Wise | Dennis Martinez | | 211 | 216 | -5 |
| 1977-06-09 | @ BOS | 54 | L 3-7 | 29-25 | 3 | 24,064 | Jim Palmer | Bill Lee | Bill Lee | Jim Palmer | Bill Campbell | 214 | 223 | -9 |
| 1977-06-10 | vs CHA | 55 | W 6-1 | 30-25 | 3 | 10,037 | Mike Flanagan | Steve Stone | Mike Flanagan | Steve Stone | | 220 | 224 | -4 |
| 1977-06-11 | vs CHA | 56 | W 4-1 | 31-25 | 3 | 31,922 | Rudy May | Ken Brett | Rudy May | Ken Brett | Dennis Martinez | 224 | 225 | -1 |
| 1977-06-12 | vs CHA | 57 | L 4-6 | 31-26 | 3 | 16,409 | Ross Grimsley | Ken Kravec | Lerrin LaGrow | Dennis Martinez | | 228 | 231 | -3 |
| 1977-06-14 | vs MIL | 58 | W 8-5 | 32-26 | 3 | 9,710 | Jim Palmer | Moose Haas | Dennis Martinez | Bill Castro | | 236 | 236 | 0 |
| 1977-06-15 | vs MIL | 59 | L 2-6 | 32-27 | 3 | 7,443 | Mike Flanagan | Jim Slaton | Jim Slaton | Mike Flanagan | Sam Hinds | 238 | 242 | -4 |
| 1977-06-16 | vs MIL | 60 | W 6-0 | 33-27 | 3 | 6,589 | Rudy May | Jerry Augustine | Rudy May | Jerry Augustine | | 244 | 242 | 2 |
| 1977-06-17 | @ TOR | 61 | W 5-3 | 34-27 | 3 | 26,183 | Ross Grimsley | Pete Vuckovich | Dennis Martinez | Pete Vuckovich | | 249 | 245 | 4 |
| 1977-06-18 | @ TOR | 62 | W 4-2 | 35-27 | 2 | 33,201 | Jim Palmer | Jesse Jefferson | Jim Palmer | Jesse Jefferson | Tippy Martinez | 253 | 247 | 6 |
| 1977-06-19 | @ TOR | 63 | L 1-7 | 35-28 | 2 | 34,556 | Mike Flanagan | Dave Lemanczyk | Dave Lemanczyk | Mike Flanagan | | 254 | 254 | 0 |
| 1977-06-20 | vs BOS | 64 | L 0-4 | 35-29 | 2 | 23,815 | Rudy May | Rick Wise | Rick Wise | Rudy May | | 254 | 258 | -4 |
| 1977-06-21 | vs BOS | 65 | L 0-7 | 35-30 | 2 | 24,174 | Dennis Martinez | Luis Tiant | Luis Tiant | Dennis Martinez | | 254 | 265 | -11 |
| 1977-06-22 | vs BOS | 66 | L 4-7 | 35-31 | 3 | 27,134 | Jim Palmer | Reggie Cleveland | Mike Paxton | Jim Palmer | Bill Campbell | 258 | 272 | -14 |
| 1977-06-23 | vs BOS | 67 | L 3-7 | 35-32 | 3 | 27,810 | Mike Flanagan | Fergie Jenkins | Fergie Jenkins | Mike Flanagan | | 261 | 279 | -18 |
| 1977-06-24 | vs TOR | 68 | L 4-5 | 35-33 | 4 | 8,133 | Rudy May | Dave Lemanczyk | Dave Lemanczyk | Fred Holdsworth | Mike Willis | 265 | 284 | -19 |
| 1977-06-25 | vs TOR | 69 | W 5-2 | 37-33 | 3 | 16,794 | Dennis Martinez | Jeff Byrd | Dennis Martinez | Jeff Byrd | | 270 | 286 | -16 |
| 1977-06-25 | vs TOR | 70 | W 3-1 | 37-33 | 3 | 16,794 | Ross Grimsley | Jerry Garvin | Ross Grimsley | Jerry Garvin | | 273 | 287 | -14 |
| 1977-06-26 | vs TOR | 71 | L 0-2 | 37-34 | 3 | 16,761 | Jim Palmer | Pete Vuckovich | Pete Vuckovich | Jim Palmer | | 273 | 289 | -16 |
| 1977-06-27 | @ CLE | 72 | W 9-2 | 38-34 | 3 | 19,320 | Mike Flanagan | Dennis Eckersley | Mike Flanagan | Dennis Eckersley | | 282 | 291 | -9 |
| 1977-06-29 | @ CLE | 73 | L 8-11 | 39-35 | 3 | 23,286 | Rudy May | Jim Bibby | Jim Bibby | Rudy May | Jim Kern | 290 | 302 | -12 |
| 1977-06-29 | @ CLE | 74 | W 5-3 | 39-35 | 3 | 23,286 | Dennis Martinez | Pat Dobson | Dick Drago | Jim Kern | | 295 | 305 | -10 |
| 1977-06-30 | @ CLE | 75 | L 2-4 | 39-36 | 3 | 6,793 | Ross Grimsley | Wayne Garland | Wayne Garland | Ross Grimsley | | 297 | 309 | -12 |
| 1977-07-01 | @ BOS | 76 | W 8-2 | 40-36 | 3 | 33,481 | Jim Palmer | Luis Tiant | Jim Palmer | Luis Tiant | | 305 | 311 | -6 |
| 1977-07-02 | @ BOS | 77 | W 5-2 | 41-36 | 3 | 32,987 | Mike Flanagan | Reggie Cleveland | Mike Flanagan | Reggie Cleveland | | 310 | 313 | -3 |
| 1977-07-03 | @ BOS | 78 | W 12-8 | 42-36 | 3 | 31,081 | Dennis Martinez | Rick Wise | Dennis Martinez | Rick Wise | Dick Drago | 322 | 321 | 1 |
| 1977-07-04 | vs DET | 79 | W 6-4 | 43-36 | 3 | 45,339 | Rudy May | Mark Fidrych | Rudy May | Mark Fidrych | Tippy Martinez | 328 | 325 | 3 |
| 1977-07-05 | vs DET | 80 | W 2-1 | 45-36 | 2 | 0 | Jim Palmer | Dave Rozema | Jim Palmer | Dave Rozema | | 330 | 326 | 4 |
| 1977-07-05 | vs DET | 81 | W 6-5 | 45-36 | 2 | 11,565 | Ross Grimsley | Milt Wilcox | Dick Drago | Jim Crawford | | 336 | 331 | 5 |
| 1977-07-06 | vs DET | 82 | W 2-0 | 46-36 | 2 | 7,341 | Mike Flanagan | Dave Roberts | Mike Flanagan | Dave Roberts | | 338 | 331 | 7 |
| 1977-07-08 | vs NYA | 83 | L 5-7 | 46-37 | 3 | 33,738 | Rudy May | Don Gullett | Don Gullett | Rudy May | Sparky Lyle | 343 | 338 | 5 |
| 1977-07-09 | vs NYA | 84 | W 6-5 | 47-37 | 3 | 44,193 | Jim Palmer | Ron Guidry | Tippy Martinez | Sparky Lyle | Dick Drago | 349 | 343 | 6 |
| 1977-07-10 | vs NYA | 85 | W 6-0 | 48-37 | 2 | 34,299 | Ross Grimsley | Ed Figueroa | Ross Grimsley | Ed Figueroa | | 355 | 343 | 12 |
| 1977-07-11 | vs NYA | 86 | W 4-3 | 49-37 | 2 | 42,603 | Mike Flanagan | Mike Torrez | Mike Flanagan | Mike Torrez | | 359 | 346 | 13 |
| 1977-07-12 | @ TEX | 87 | L 3-4 | 49-38 | 2 | 8,646 | Rudy May | Doyle Alexander | Doyle Alexander | Dick Drago | | 362 | 350 | 12 |
| 1977-07-13 | @ TEX | 88 | W 4-3 | 50-38 | 2 | 16,805 | Jim Palmer | Dock Ellis | Jim Palmer | Dock Ellis | Tippy Martinez | 366 | 353 | 13 |
| 1977-07-14 | @ TEX | 89 | W 6-1 | 51-38 | 2 | 14,205 | Ross Grimsley | Gaylord Perry | Ross Grimsley | Gaylord Perry | | 372 | 354 | 18 |
| 1977-07-15 | @ MIL | 90 | W 4-2 | 52-38 | 1 | 13,185 | Mike Flanagan | Mike Caldwell | Mike Flanagan | Mike Caldwell | | 376 | 356 | 20 |
| 1977-07-16 | @ MIL | 91 | W 5-0 | 53-38 | 1 | 21,301 | Rudy May | Lary Sorensen | Rudy May | Lary Sorensen | | 381 | 356 | 25 |
| 1977-07-17 | @ MIL | 92 | L 2-3 | 53-39 | 1 | 16,231 | Dennis Martinez | Moose Haas | Moose Haas | Dennis Martinez | Bill Castro | 383 | 359 | 24 |
| 1977-07-22 | vs TEX | 93 | L 1-5 | 53-40 | 2 | 39,323 | Ross Grimsley | Bert Blyleven | Bert Blyleven | Ross Grimsley | | 384 | 364 | 20 |
| 1977-07-23 | vs TEX | 94 | L 0-1 | 53-41 | 2 | 10,738 | Jim Palmer | Gaylord Perry | Adrian Devine | Dick Drago | | 384 | 365 | 19 |
| 1977-07-24 | vs MIL | 95 | W 3-2 | 55-41 | 1 | 19,411 | Mike Flanagan | Moose Haas | Mike Flanagan | Moose Haas | | 387 | 367 | 20 |
| 1977-07-24 | vs MIL | 96 | W 4-3 | 55-41 | 1 | 19,411 | Rudy May | Jerry Augustine | Dick Drago | Jerry Augustine | | 391 | 370 | 21 |
| 1977-07-25 | vs MIL | 97 | W 4-3 | 56-41 | 1 | 8,219 | Dennis Martinez | Jim Slaton | Tippy Martinez | Sam Hinds | | 395 | 373 | 22 |
| 1977-07-26 | @ NYA | 98 | L 4-5 | 56-42 | 1 | 32,097 | Ross Grimsley | Ed Figueroa | Sparky Lyle | Scott McGregor | | 399 | 378 | 21 |
| 1977-07-27 | @ NYA | 99 | W 6-4 | 57-42 | 1 | 47,271 | Jim Palmer | Catfish Hunter | Jim Palmer | Catfish Hunter | Tippy Martinez | 405 | 382 | 23 |
| 1977-07-28 | @ NYA | 100 | L 2-14 | 57-43 | 1 | 40,818 | Rudy May | Mike Torrez | Mike Torrez | Rudy May | | 407 | 396 | 11 |
| 1977-07-29 | @ SEA | 101 | W 5-4 | 58-43 | 1 | 14,313 | Mike Flanagan | Bob Galasso | Dick Drago | Mike Kekich | | 412 | 400 | 12 |
| 1977-07-30 | @ SEA | 102 | W 5-3 | 59-43 | 1 | 31,609 | Ross Grimsley | Dick Pole | Dennis Martinez | John Montague | | 417 | 403 | 14 |
| 1977-07-31 | @ SEA | 103 | L 1-6 | 59-44 | 2 | 11,464 | Jim Palmer | Glenn Abbott | Glenn Abbott | Jim Palmer | | 418 | 409 | 9 |
| 1977-08-01 | @ OAK | 104 | W 5-1 | 60-44 | 1 | 8,831 | Rudy May | Joe Coleman | Rudy May | Joe Coleman | | 423 | 410 | 13 |
| 1977-08-03 | @ OAK | 105 | W 8-6 | 61-44 | 2 | 5,103 | Mike Flanagan | Rick Langford | Tippy Martinez | Bob Lacey | | 431 | 416 | 15 |
| 1977-08-05 | @ CAL | 106 | L 0-5 | 61-45 | 2 | 18,078 | Ross Grimsley | Frank Tanana | Frank Tanana | Ross Grimsley | | 431 | 421 | 10 |
| 1977-08-06 | @ CAL | 107 | L 5-9 | 61-46 | 2 | 20,859 | Rudy May | Ken Brett | Ken Brett | Rudy May | | 436 | 430 | 6 |
| 1977-08-07 | @ CAL | 108 | L 3-6 | 61-47 | 2 | 15,729 | Jim Palmer | Paul Hartzell | Dave LaRoche | Jim Palmer | Dyar Miller | 439 | 436 | 3 |
| 1977-08-08 | vs CLE | 109 | W 6-3 | 62-47 | 2 | 11,431 | Mike Flanagan | Jim Bibby | Dennis Martinez | Jim Bibby | | 445 | 439 | 6 |
| 1977-08-09 | vs CLE | 110 | W 3-1 | 63-47 | 2 | 8,797 | Ross Grimsley | Al Fitzmorris | Ross Grimsley | Al Fitzmorris | | 448 | 440 | 8 |
| 1977-08-10 | vs SEA | 111 | W 5-4 | 64-47 | 2 | 7,579 | Rudy May | Dick Pole | Rudy May | Dick Pole | Dick Drago | 453 | 444 | 9 |
| 1977-08-11 | vs SEA | 112 | W 4-3 | 65-47 | 2 | 7,893 | Scott McGregor | Glenn Abbott | Dick Drago | Enrique Romo | | 457 | 447 | 10 |
| 1977-08-12 | vs OAK | 113 | W 6-1 | 66-47 | 2 | 31,778 | Jim Palmer | Vida Blue | Jim Palmer | Vida Blue | | 463 | 448 | 15 |
| 1977-08-13 | vs OAK | 114 | L 6-9 | 66-48 | 2 | 16,522 | Mike Flanagan | Rick Langford | Rick Langford | Mike Flanagan | Doug Bair | 469 | 457 | 12 |
| 1977-08-14 | vs OAK | 115 | W 5-4 | 67-48 | 2 | 9,579 | Ross Grimsley | Doc Medich | Ross Grimsley | Doc Medich | Tippy Martinez | 474 | 461 | 13 |
| 1977-08-15 | vs MIN | 116 | L 9-13 | 67-49 | 2 | 18,115 | Rudy May | Dave Goltz | Ron Schueler | Rudy May | | 483 | 474 | 9 |
| 1977-08-16 | vs MIN | 117 | W 6-5 | 68-49 | 2 | 20,846 | Jim Palmer | Pete Redfern | Dennis Martinez | Tom Johnson | | 489 | 479 | 10 |
| 1977-08-19 | @ MIN | 118 | W 3-2 | 69-49 | 2 | 19,356 | Mike Flanagan | Dave Goltz | Mike Flanagan | Dave Goltz | | 492 | 481 | 11 |
| 1977-08-20 | @ MIN | 119 | W 6-2 | 70-49 | 2 | 18,668 | Ross Grimsley | Pete Redfern | Ross Grimsley | Pete Redfern | Dennis Martinez | 498 | 483 | 15 |
| 1977-08-21 | @ MIN | 120 | L 5-9 | 70-50 | 3 | 23,333 | Rudy May | Geoff Zahn | Ron Schueler | Rudy May | | 503 | 492 | 11 |
| 1977-08-22 | @ KCA | 121 | L 7-8 | 70-51 | 3 | 36,328 | Jim Palmer | Dennis Leonard | Steve Mingori | Tippy Martinez | | 510 | 500 | 10 |
| 1977-08-23 | @ KCA | 122 | L 2-5 | 70-52 | 3 | 27,602 | Mike Flanagan | Jim Colborn | Jim Colborn | Mike Flanagan | Larry Gura | 512 | 505 | 7 |
| 1977-08-24 | vs CHA | 123 | W 10-5 | 71-52 | 2 | 10,913 | Ross Grimsley | Steve Stone | Scott McGregor | Steve Stone | | 522 | 510 | 12 |
| 1977-08-25 | vs CHA | 124 | L 4-6 | 71-53 | 3 | 12,673 | Rudy May | Ken Kravec | Dave Hamilton | Dennis Martinez | Lerrin LaGrow | 526 | 516 | 10 |
| 1977-08-26 | vs KCA | 125 | L 2-3 | 71-54 | 3 | 21,511 | Jim Palmer | Dennis Leonard | Dennis Leonard | Jim Palmer | | 528 | 519 | 9 |
| 1977-08-27 | vs KCA | 126 | W 4-2 | 72-54 | 3 | 17,074 | Mike Flanagan | Jim Colborn | Mike Flanagan | Jim Colborn | Dennis Martinez | 532 | 521 | 11 |
| 1977-08-28 | vs KCA | 127 | L 0-5 | 72-55 | 3 | 15,764 | Ross Grimsley | Andy Hassler | Andy Hassler | Ross Grimsley | Doug Bird | 532 | 526 | 6 |
| 1977-08-29 | vs CAL | 128 | W 6-1 | 73-55 | 3 | 10,103 | Rudy May | Nolan Ryan | Rudy May | Nolan Ryan | | 538 | 527 | 11 |
| 1977-08-30 | vs CAL | 129 | W 8-2 | 74-55 | 3 | 7,583 | Jim Palmer | Ken Brett | Jim Palmer | Ken Brett | | 546 | 529 | 17 |
| 1977-08-31 | vs CAL | 130 | W 4-3 | 75-55 | 2 | 9,416 | Dennis Martinez | Frank Tanana | Dennis Martinez | Frank Tanana | | 550 | 532 | 18 |
| 1977-09-02 | @ CHA | 131 | W 6-5 | 76-55 | 2 | 24,226 | Mike Flanagan | Steve Renko | Dick Drago | Lerrin LaGrow | Tippy Martinez | 556 | 537 | 19 |
| 1977-09-03 | @ CHA | 132 | L 3-6 | 76-56 | 3 | 29,144 | Ross Grimsley | Francisco Barrios | Clay Carroll | Scott McGregor | | 559 | 543 | 16 |
| 1977-09-04 | @ CHA | 133 | W 7-5 | 77-56 | 3 | 48,952 | Jim Palmer | Steve Stone | Tippy Martinez | Clay Carroll | | 566 | 548 | 18 |
| 1977-09-05 | @ DET | 134 | L 7-8 | 78-57 | 3 | 22,062 | Dennis Martinez | Milt Wilcox | Jim Crawford | Dick Drago | | 573 | 556 | 17 |
| 1977-09-05 | @ DET | 135 | W 5-0 | 78-57 | 3 | 22,062 | Rudy May | Steve Grilli | Rudy May | Steve Grilli | | 578 | 556 | 22 |
| 1977-09-06 | @ DET | 136 | W 7-2 | 79-57 | 3 | 7,851 | Mike Flanagan | Fernando Arroyo | Mike Flanagan | Fernando Arroyo | | 585 | 558 | 27 |
| 1977-09-07 | @ DET | 137 | W 6-2 | 80-58 | 3 | 11,032 | Scott McGregor | Jim Crawford | Scott McGregor | John Hiller | | 591 | 560 | 31 |
| 1977-09-07 | @ DET | 138 | L 5-12 | 80-58 | 3 | 11,032 | Ross Grimsley | Ed Glynn | Ed Glynn | Ross Grimsley | | 596 | 572 | 24 |
| 1977-09-08 | @ DET | 139 | W 4-0 | 81-58 | 3 | 1,969 | Jim Palmer | Bob Sykes | Jim Palmer | Bob Sykes | | 600 | 572 | 28 |
| 1977-09-09 | vs CLE | 140 | W 7-1 | 82-58 | 3 | 5,930 | Rudy May | Al Fitzmorris | Rudy May | Al Fitzmorris | | 607 | 573 | 34 |
| 1977-09-10 | vs CLE | 141 | W 6-5 | 83-58 | 3 | 8,748 | Mike Flanagan | Rick Waits | Dennis Martinez | Jim Kern | | 613 | 578 | 35 |
| 1977-09-11 | vs CLE | 142 | W 9-5 | 84-58 | 3 | 12,540 | Ross Grimsley | Pat Dobson | Ross Grimsley | Pat Dobson | | 622 | 583 | 39 |
| 1977-09-12 | @ TOR | 143 | W 6-3 | 85-58 | 3 | 13,498 | Jim Palmer | Dave Lemanczyk | Jim Palmer | Dave Lemanczyk | Tippy Martinez | 628 | 586 | 42 |
| 1977-09-14 | @ TOR | 144 | W 6-5 | 87-58 | 2 | 19,048 | Mike Flanagan | Jesse Jefferson | Mike Flanagan | Jesse Jefferson | Scott McGregor | 634 | 591 | 43 |
| 1977-09-14 | @ TOR | 145 | W 4-2 | 87-58 | 2 | 19,048 | Rudy May | Jerry Garvin | Rudy May | Jerry Garvin | Scott McGregor | 638 | 593 | 45 |
| 1977-09-15 | @ TOR | 146 | L 0-4 | 87-59 | 2 | 14,015 | Ross Grimsley | Jim Clancy | Jim Clancy | Ross Grimsley | | 638 | 597 | 41 |
| 1977-09-16 | vs BOS | 147 | W 6-1 | 88-59 | 2 | 29,736 | Jim Palmer | Don Aase | Jim Palmer | Don Aase | | 644 | 598 | 46 |
| 1977-09-17 | vs BOS | 148 | W 11-2 | 89-59 | 2 | 26,324 | Dennis Martinez | Bill Lee | Dennis Martinez | Bill Lee | | 655 | 600 | 55 |
| 1977-09-18 | vs BOS | 149 | L 4-10 | 89-60 | 2 | 51,798 | Mike Flanagan | Mike Paxton | Bob Stanley | Scott McGregor | Bill Campbell | 659 | 610 | 49 |
| 1977-09-19 | vs TOR | 150 | L 1-3 | 89-61 | 2 | 3,325 | Rudy May | Jerry Garvin | Jerry Garvin | Rudy May | | 660 | 613 | 47 |
| 1977-09-20 | vs TOR | 151 | W 5-2 | 90-61 | 2 | 4,301 | Jim Palmer | Jim Clancy | Jim Palmer | Jim Clancy | | 665 | 615 | 50 |
| 1977-09-21 | vs TOR | 152 | W 4-0 | 91-61 | 2 | 4,237 | Ross Grimsley | Jeff Byrd | Ross Grimsley | Jeff Byrd | | 669 | 615 | 54 |
| 1977-09-22 | vs TOR | 153 | W 7-1 | 92-61 | 2 | 9,261 | Mike Flanagan | Dave Lemanczyk | Mike Flanagan | Dave Lemanczyk | | 676 | 616 | 60 |
| 1977-09-23 | @ CLE | 154 | L 2-3 | 92-62 | 2 | 4,787 | Rudy May | Rick Waits | Rick Waits | Rudy May | Jim Bibby | 678 | 619 | 59 |
| 1977-09-24 | @ CLE | 155 | W 4-1 | 93-62 | 2 | 4,098 | Jim Palmer | Dennis Eckersley | Jim Palmer | Dennis Eckersley | | 682 | 620 | 62 |
| 1977-09-25 | @ CLE | 156 | L 4-9 | 93-63 | 3 | 6,291 | Ross Grimsley | Wayne Garland | Wayne Garland | Ross Grimsley | | 686 | 629 | 57 |
| 1977-09-27 | vs DET | 157 | W 6-1 | 94-63 | 3 | 4,854 | Mike Flanagan | Fernando Arroyo | Mike Flanagan | Fernando Arroyo | | 692 | 630 | 62 |
| 1977-09-28 | vs DET | 158 | W 3-2 | 95-63 | 2 | 7,547 | Jim Palmer | Vern Ruhle | Jim Palmer | Steve Foucault | | 695 | 632 | 63 |
| 1977-09-29 | vs DET | 159 | W 6-3 | 96-63 | 2 | 6,241 | Rudy May | Jim Crawford | Rudy May | Jim Crawford | Tippy Martinez | 701 | 635 | 66 |
| 1977-09-30 | @ BOS | 160 | L 10-11 | 96-64 | 3 | 28,553 | Dennis Martinez | Reggie Cleveland | Bill Campbell | Scott McGregor | Bob Stanley | 711 | 646 | 65 |
| 1977-10-01 | @ BOS | 161 | W 8-7 | 97-64 | 2 | 29,107 | Mike Flanagan | Rick Wise | Mike Flanagan | Jim Willoughby | Nelson Briles | 719 | 653 | 66 |