| 1977-04-06 | @ SEA | 1 | W 7-0 | 1-0 | 1 | 57,762 | Frank Tanana | Diego Segui | Frank Tanana | Diego Segui | | 7 | 0 | 7 |
| 1977-04-07 | @ SEA | 2 | W 2-0 | 2-0 | 3 | 10,144 | Nolan Ryan | Enrique Romo | Nolan Ryan | Enrique Romo | | 9 | 0 | 9 |
| 1977-04-08 | @ SEA | 3 | L 6-7 | 2-1 | 3 | 11,845 | Gary Ross | Stan Thomas | Bill Laxton | John Verhoeven | | 15 | 7 | 8 |
| 1977-04-09 | @ SEA | 4 | L 1-5 | 2-2 | 6 | 27,668 | Wayne Simpson | Gary Wheelock | Gary Wheelock | Wayne Simpson | John Montague | 16 | 12 | 4 |
| 1977-04-10 | @ SEA | 5 | W 12-5 | 3-2 | 4 | 10,405 | Frank Tanana | Glenn Abbott | Frank Tanana | Glenn Abbott | | 28 | 17 | 11 |
| 1977-04-11 | @ OAK | 6 | L 2-3 | 3-3 | 5 | 12,337 | Nolan Ryan | Mike Norris | Pablo Torrealba | Nolan Ryan | | 30 | 20 | 10 |
| 1977-04-12 | @ OAK | 7 | L 2-6 | 3-4 | 6 | 2,184 | Gary Ross | Stan Bahnsen | Stan Bahnsen | Gary Ross | Dave Giusti | 32 | 26 | 6 |
| 1977-04-13 | @ OAK | 8 | L 3-9 | 3-5 | 7 | 3,017 | Wayne Simpson | Rick Langford | Rick Langford | Wayne Simpson | Pablo Torrealba | 35 | 35 | 0 |
| 1977-04-14 | @ OAK | 9 | L 7-8 | 3-6 | 7 | 4,738 | Frank Tanana | Doc Medich | Doug Bair | John Verhoeven | | 42 | 43 | -1 |
| 1977-04-15 | vs SEA | 10 | W 7-0 | 4-6 | 6 | 34,654 | Nolan Ryan | Glenn Abbott | Nolan Ryan | Glenn Abbott | | 49 | 43 | 6 |
| 1977-04-16 | vs SEA | 11 | W 6-4 | 5-6 | 5 | 19,690 | Paul Hartzell | Diego Segui | Paul Hartzell | John Montague | Don Kirkwood | 55 | 47 | 8 |
| 1977-04-17 | vs SEA | 12 | L 7-11 | 5-7 | 7 | 13,813 | Wayne Simpson | Enrique Romo | Mike Kekich | Sid Monge | Dave Pagan | 62 | 58 | 4 |
| 1977-04-19 | vs CHA | 13 | W 11-2 | 6-7 | 6 | 12,625 | Frank Tanana | Bart Johnson | Frank Tanana | Bart Johnson | | 73 | 60 | 13 |
| 1977-04-20 | vs CHA | 14 | L 2-3 | 6-8 | 6 | 14,373 | Nolan Ryan | Chris Knapp | Chris Knapp | Nolan Ryan | Lerrin LaGrow | 75 | 63 | 12 |
| 1977-04-22 | vs MIL | 15 | W 7-4 | 7-8 | 6 | 14,773 | Wayne Simpson | Moose Haas | Wayne Simpson | Moose Haas | Dick Drago | 82 | 67 | 15 |
| 1977-04-23 | vs MIL | 16 | L 1-4 | 7-9 | 6 | 42,368 | Paul Hartzell | Bill Travers | Bill Travers | Paul Hartzell | Bill Castro | 83 | 71 | 12 |
| 1977-04-24 | vs MIL | 17 | L 9-10 | 7-10 | 6 | 14,878 | Frank Tanana | Jim Slaton | Gary Beare | Mickey Scott | Bill Castro | 92 | 81 | 11 |
| 1977-04-25 | vs OAK | 18 | W 11-6 | 8-10 | 6 | 12,396 | Nolan Ryan | Doc Medich | Nolan Ryan | Doc Medich | Sid Monge | 103 | 87 | 16 |
| 1977-04-26 | vs OAK | 19 | L 3-7 | 8-11 | 6 | 11,506 | Wayne Simpson | Vida Blue | Vida Blue | Dick Drago | | 106 | 94 | 12 |
| 1977-04-27 | vs OAK | 20 | L 5-7 | 8-12 | 6 | 13,475 | Paul Hartzell | Jim Umbarger | Rick Langford | Paul Hartzell | Stan Bahnsen | 111 | 101 | 10 |
| 1977-04-29 | @ BAL | 21 | W 3-2 | 9-12 | 6 | 8,155 | Frank Tanana | Jim Palmer | Frank Tanana | Dyar Miller | | 114 | 103 | 11 |
| 1977-04-30 | @ BAL | 22 | L 3-4 | 9-13 | 6 | 9,138 | Nolan Ryan | Mike Flanagan | Dennis Martinez | Nolan Ryan | | 117 | 107 | 10 |
| 1977-05-01 | @ BAL | 23 | L 2-3 | 9-14 | 6 | 9,061 | Gary Ross | Ross Grimsley | Ross Grimsley | Paul Hartzell | | 119 | 110 | 9 |
| 1977-05-03 | @ NYA | 24 | L 1-8 | 9-15 | 6 | 19,440 | Mike Cuellar | Mike Torrez | Mike Torrez | Mike Cuellar | Dick Tidrow | 120 | 118 | 2 |
| 1977-05-06 | @ BOS | 25 | W 8-4 | 10-15 | 6 | 24,301 | Nolan Ryan | Luis Tiant | Nolan Ryan | Luis Tiant | Paul Hartzell | 128 | 122 | 6 |
| 1977-05-07 | @ BOS | 26 | L 0-3 | 10-16 | 6 | 28,426 | Frank Tanana | Bob Stanley | Bob Stanley | Frank Tanana | | 128 | 125 | 3 |
| 1977-05-08 | @ BOS | 27 | L 3-4 | 10-17 | 6 | 20,864 | Gary Ross | Bill Lee | Jim Willoughby | Gary Ross | | 131 | 129 | 2 |
| 1977-05-09 | @ KCA | 28 | W 5-3 | 11-17 | 6 | 21,901 | Wayne Simpson | Jim Colborn | Wayne Simpson | Jim Colborn | Paul Hartzell | 136 | 132 | 4 |
| 1977-05-10 | @ KCA | 29 | W 6-1 | 12-17 | 6 | 16,740 | Nolan Ryan | Paul Splittorff | Nolan Ryan | Paul Splittorff | | 142 | 133 | 9 |
| 1977-05-11 | vs BAL | 30 | W 6-0 | 13-17 | 6 | 11,025 | Frank Tanana | Ross Grimsley | Frank Tanana | Ross Grimsley | | 148 | 133 | 15 |
| 1977-05-12 | vs BAL | 31 | W 7-5 | 14-17 | 6 | 10,208 | Gary Ross | Jim Palmer | Don Kirkwood | Jim Palmer | Dave LaRoche | 155 | 138 | 17 |
| 1977-05-13 | vs NYA | 32 | L 0-3 | 14-18 | 6 | 24,028 | Wayne Simpson | Ed Figueroa | Ed Figueroa | Wayne Simpson | | 155 | 141 | 14 |
| 1977-05-14 | vs NYA | 33 | L 1-4 | 14-19 | 6 | 44,000 | Nolan Ryan | Don Gullett | Don Gullett | Nolan Ryan | | 156 | 145 | 11 |
| 1977-05-15 | vs NYA | 34 | W 8-2 | 15-19 | 6 | 27,260 | Frank Tanana | Mike Torrez | Frank Tanana | Mike Torrez | | 164 | 147 | 17 |
| 1977-05-16 | vs BOS | 35 | L 7-8 | 15-20 | 6 | 11,714 | Gary Ross | Reggie Cleveland | Bill Campbell | Paul Hartzell | | 171 | 155 | 16 |
| 1977-05-17 | vs BOS | 36 | W 6-2 | 16-20 | 6 | 13,883 | Wayne Simpson | Fergie Jenkins | Wayne Simpson | Fergie Jenkins | Paul Hartzell | 177 | 157 | 20 |
| 1977-05-19 | vs MIN | 37 | W 5-3 | 17-20 | 6 | 15,167 | Nolan Ryan | Dave Goltz | Nolan Ryan | Dave Goltz | | 182 | 160 | 22 |
| 1977-05-20 | vs MIN | 38 | W 3-0 | 18-20 | 6 | 24,164 | Frank Tanana | Paul Thormodsgard | Frank Tanana | Paul Thormodsgard | | 185 | 160 | 25 |
| 1977-05-21 | vs MIN | 39 | W 5-1 | 19-20 | 4 | 24,139 | Gary Ross | Geoff Zahn | Gary Ross | Geoff Zahn | Dave LaRoche | 190 | 161 | 29 |
| 1977-05-22 | vs MIN | 40 | L 5-8 | 19-21 | 4 | 21,048 | Wayne Simpson | Pete Redfern | Tom Johnson | Mickey Scott | | 195 | 169 | 26 |
| 1977-05-24 | @ DET | 41 | W 2-1 | 20-21 | 4 | 14,194 | Nolan Ryan | John Hiller | Nolan Ryan | John Hiller | | 197 | 170 | 27 |
| 1977-05-25 | @ DET | 42 | W 4-0 | 21-21 | 4 | 13,150 | Frank Tanana | Dave Roberts | Frank Tanana | Dave Roberts | | 201 | 170 | 31 |
| 1977-05-27 | @ TOR | 43 | W 4-1 | 22-21 | 4 | 24,779 | Gary Ross | Bill Singer | Gary Ross | Jerry Johnson | Paul Hartzell | 205 | 171 | 34 |
| 1977-05-28 | @ TOR | 44 | L 4-6 | 22-22 | 4 | 30,034 | Wayne Simpson | Jesse Jefferson | Jesse Jefferson | Wayne Simpson | Pete Vuckovich | 209 | 177 | 32 |
| 1977-05-29 | @ TOR | 45 | W 3-2 | 23-22 | 4 | 30,009 | Nolan Ryan | Dave Lemanczyk | Nolan Ryan | Dave Lemanczyk | | 212 | 179 | 33 |
| 1977-05-30 | @ CLE | 46 | L 0-1 | 23-23 | 4 | 13,400 | Frank Tanana | Dennis Eckersley | Dennis Eckersley | Frank Tanana | | 212 | 180 | 32 |
| 1977-05-31 | @ CLE | 47 | W 7-6 | 24-23 | 3 | 5,174 | Paul Hartzell | Wayne Garland | Dave LaRoche | Jim Kern | Dick Drago | 219 | 186 | 33 |
| 1977-06-04 | vs DET | 48 | L 6-9 | 24-24 | 5 | 30,331 | Nolan Ryan | Dave Roberts | John Hiller | Nolan Ryan | | 225 | 195 | 30 |
| 1977-06-05 | vs DET | 49 | W 5-1 | 25-24 | 4 | 21,032 | Frank Tanana | Fernando Arroyo | Frank Tanana | Fernando Arroyo | | 230 | 196 | 34 |
| 1977-06-06 | vs DET | 50 | L 0-8 | 25-25 | 4 | 38,551 | Gary Ross | Mark Fidrych | Mark Fidrych | Gary Ross | | 230 | 204 | 26 |
| 1977-06-07 | vs TOR | 51 | L 3-6 | 25-26 | 5 | 10,239 | Paul Hartzell | Pete Vuckovich | Mike Willis | Paul Hartzell | | 233 | 210 | 23 |
| 1977-06-08 | vs TOR | 52 | W 2-1 | 26-26 | 4 | 11,678 | Nolan Ryan | Jesse Jefferson | Dave LaRoche | Tom Bruno | | 235 | 211 | 24 |
| 1977-06-10 | vs CLE | 53 | W 1-0 | 27-26 | 4 | 20,000 | Frank Tanana | Wayne Garland | Frank Tanana | Wayne Garland | | 236 | 211 | 25 |
| 1977-06-11 | vs CLE | 54 | L 1-3 | 27-27 | 4 | 16,247 | Gary Ross | Jim Bibby | Jim Bibby | Gary Ross | Jim Kern | 237 | 214 | 23 |
| 1977-06-12 | vs CLE | 55 | W 11-4 | 28-27 | 3 | 23,926 | Nolan Ryan | Pat Dobson | Nolan Ryan | Pat Dobson | Dave LaRoche | 248 | 218 | 30 |
| 1977-06-14 | @ MIN | 56 | W 12-9 | 29-27 | 3 | 12,344 | Paul Hartzell | Pete Redfern | Dyar Miller | Ron Schueler | Dave LaRoche | 260 | 227 | 33 |
| 1977-06-15 | @ MIN | 57 | L 2-3 | 29-28 | 4 | 11,724 | Frank Tanana | Dave Goltz | Dave Goltz | Frank Tanana | | 262 | 230 | 32 |
| 1977-06-16 | @ MIN | 58 | L 6-7 | 29-29 | 4 | 21,036 | Nolan Ryan | Paul Thormodsgard | Tom Johnson | Nolan Ryan | | 268 | 237 | 31 |
| 1977-06-17 | @ MIL | 59 | W 7-5 | 30-29 | 4 | 10,881 | Ken Brett | Lary Sorensen | Dyar Miller | Bill Castro | | 275 | 242 | 33 |
| 1977-06-18 | @ MIL | 60 | L 2-4 | 30-30 | 4 | 47,949 | Gary Nolan | Gary Beare | Gary Beare | Gary Nolan | Bill Castro | 277 | 246 | 31 |
| 1977-06-19 | @ MIL | 61 | W 7-0 | 31-30 | 3 | 14,244 | Frank Tanana | Moose Haas | Frank Tanana | Moose Haas | | 284 | 246 | 38 |
| 1977-06-21 | @ CHA | 62 | L 2-3 | 31-31 | 5 | 15,755 | Nolan Ryan | Steve Stone | Steve Stone | Nolan Ryan | Lerrin LaGrow | 286 | 249 | 37 |
| 1977-06-22 | @ CHA | 63 | L 2-6 | 31-32 | 5 | 12,912 | Ken Brett | Ken Kravec | Bart Johnson | Ken Brett | | 288 | 255 | 33 |
| 1977-06-23 | @ CHA | 64 | W 10-6 | 32-32 | 5 | 17,525 | Wayne Simpson | Francisco Barrios | Dyar Miller | Larry Anderson | | 298 | 261 | 37 |
| 1977-06-24 | vs TEX | 65 | L 0-1 | 32-33 | 5 | 18,983 | Frank Tanana | Gaylord Perry | Adrian Devine | Frank Tanana | | 298 | 262 | 36 |
| 1977-06-25 | vs TEX | 66 | W 3-2 | 33-33 | 5 | 15,247 | Nolan Ryan | Dock Ellis | Dave LaRoche | Mike Marshall | | 301 | 264 | 37 |
| 1977-06-26 | vs TEX | 67 | W 4-3 | 35-33 | 3 | 0 | Gary Ross | Doyle Alexander | Paul Hartzell | Doyle Alexander | | 305 | 267 | 38 |
| 1977-06-26 | vs TEX | 68 | W 4-3 | 35-33 | 3 | 37,768 | Ken Brett | Nelson Briles | Paul Hartzell | Adrian Devine | Dave LaRoche | 309 | 270 | 39 |
| 1977-06-27 | vs KCA | 69 | L 2-7 | 35-34 | 4 | 14,794 | Wayne Simpson | Andy Hassler | Andy Hassler | Wayne Simpson | | 311 | 277 | 34 |
| 1977-06-28 | vs KCA | 70 | L 1-3 | 35-35 | 4 | 16,103 | Frank Tanana | Dennis Leonard | Dennis Leonard | Frank Tanana | | 312 | 280 | 32 |
| 1977-06-29 | vs KCA | 71 | W 7-0 | 36-35 | 4 | 17,550 | Nolan Ryan | Jim Colborn | Nolan Ryan | Jim Colborn | | 319 | 280 | 39 |
| 1977-07-01 | vs OAK | 72 | L 0-2 | 36-36 | 4 | 13,496 | Ken Brett | Vida Blue | Vida Blue | Ken Brett | | 319 | 282 | 37 |
| 1977-07-02 | vs OAK | 73 | L 4-9 | 36-37 | 4 | 15,057 | Gary Ross | Doc Medich | Bob Lacey | Dyar Miller | | 323 | 291 | 32 |
| 1977-07-03 | vs OAK | 74 | W 6-4 | 37-37 | 4 | 14,352 | Frank Tanana | Mike Norris | Frank Tanana | Mike Norris | | 329 | 295 | 34 |
| 1977-07-04 | vs OAK | 75 | W 4-2 | 38-37 | 4 | 41,303 | Nolan Ryan | Rick Langford | Nolan Ryan | Rick Langford | | 333 | 297 | 36 |
| 1977-07-05 | vs OAK | 76 | W 6-0 | 39-37 | 4 | 12,957 | Wayne Simpson | Vida Blue | Wayne Simpson | Vida Blue | Dyar Miller | 339 | 297 | 42 |
| 1977-07-06 | @ MIN | 77 | L 3-4 | 39-38 | 4 | 10,690 | Ken Brett | Pete Redfern | Tom Johnson | Paul Hartzell | | 342 | 301 | 41 |
| 1977-07-07 | @ MIN | 78 | L 6-8 | 39-39 | 4 | 18,121 | Frank Tanana | Ron Schueler | Ron Schueler | Frank Tanana | Tom Johnson | 348 | 309 | 39 |
| 1977-07-08 | @ TEX | 79 | L 5-9 | 39-40 | 5 | 34,238 | Nolan Ryan | Dock Ellis | Dock Ellis | Nolan Ryan | Darold Knowles | 353 | 318 | 35 |
| 1977-07-09 | @ TEX | 80 | L 2-7 | 39-41 | 5 | 17,550 | Wayne Simpson | Gaylord Perry | Gaylord Perry | Wayne Simpson | | 355 | 325 | 30 |
| 1977-07-10 | @ TEX | 81 | L 2-4 | 39-42 | 5 | 14,321 | Ken Brett | Bert Blyleven | Bert Blyleven | Ken Brett | Adrian Devine | 357 | 329 | 28 |
| 1977-07-11 | vs MIN | 82 | W 6-5 | 40-42 | 5 | 30,403 | Frank Tanana | Pete Redfern | Dave LaRoche | Dave Johnson | | 363 | 334 | 29 |
| 1977-07-12 | vs MIN | 83 | W 3-0 | 41-42 | 5 | 16,117 | Nolan Ryan | Paul Thormodsgard | Nolan Ryan | Paul Thormodsgard | | 366 | 334 | 32 |
| 1977-07-13 | vs MIN | 84 | L 3-6 | 41-43 | 5 | 15,276 | Paul Hartzell | Dave Goltz | Dave Goltz | Wayne Simpson | | 369 | 340 | 29 |
| 1977-07-14 | vs SEA | 85 | L 1-4 | 41-44 | 5 | 11,400 | Ken Brett | Dick Pole | Dick Pole | Ken Brett | Enrique Romo | 370 | 344 | 26 |
| 1977-07-15 | vs SEA | 86 | L 2-6 | 41-45 | 5 | 11,383 | Gary Nolan | Tom House | Tom House | Gary Nolan | | 372 | 350 | 22 |
| 1977-07-16 | vs SEA | 87 | W 5-4 | 42-45 | 5 | 29,068 | Nolan Ryan | Diego Segui | Nolan Ryan | Enrique Romo | | 377 | 354 | 23 |
| 1977-07-17 | vs SEA | 88 | L 7-8 | 42-46 | 5 | 10,879 | Paul Hartzell | Gary Wheelock | Mike Kekich | Dave LaRoche | | 384 | 362 | 22 |
| 1977-07-21 | @ MIN | 89 | L 2-3 | 42-47 | 5 | 21,239 | Nolan Ryan | Dave Goltz | Dave Goltz | Nolan Ryan | | 386 | 365 | 21 |
| 1977-07-22 | @ MIN | 90 | W 6-2 | 43-47 | 5 | 19,133 | Ken Brett | Paul Thormodsgard | Ken Brett | Paul Thormodsgard | | 392 | 367 | 25 |
| 1977-07-23 | @ MIN | 91 | L 4-10 | 43-48 | 5 | 18,207 | Frank Tanana | Pete Redfern | Pete Redfern | Mike Barlow | | 396 | 377 | 19 |
| 1977-07-24 | @ SEA | 92 | W 3-1 | 45-48 | 5 | 0 | Paul Hartzell | Tom House | Paul Hartzell | Tom House | Dyar Miller | 399 | 378 | 21 |
| 1977-07-24 | @ SEA | 93 | W 4-3 | 45-48 | 5 | 25,344 | Wayne Simpson | Bob Galasso | Wayne Simpson | Bob Galasso | Dave LaRoche | 403 | 381 | 22 |
| 1977-07-25 | @ SEA | 94 | W 7-2 | 46-48 | 5 | 10,886 | Nolan Ryan | Dick Pole | Nolan Ryan | Dick Pole | | 410 | 383 | 27 |
| 1977-07-26 | @ OAK | 95 | L 1-2 | 46-49 | 5 | 7,757 | Frank Tanana | Vida Blue | Vida Blue | Frank Tanana | | 411 | 385 | 26 |
| 1977-07-27 | @ OAK | 96 | W 9-3 | 47-49 | 5 | 5,501 | Ken Brett | Paul Mitchell | Ken Brett | Paul Mitchell | | 420 | 388 | 32 |
| 1977-07-28 | @ OAK | 97 | L 4-6 | 47-50 | 5 | 6,068 | Wayne Simpson | Joe Coleman | Joe Coleman | Wayne Simpson | Dave Giusti | 424 | 394 | 30 |
| 1977-07-29 | vs BOS | 98 | L 5-6 | 47-51 | 5 | 23,542 | Paul Hartzell | Fergie Jenkins | Bill Campbell | Dyar Miller | | 429 | 400 | 29 |
| 1977-07-30 | vs BOS | 99 | L 0-3 | 47-52 | 5 | 32,662 | Nolan Ryan | Luis Tiant | Luis Tiant | Nolan Ryan | Bob Stanley | 429 | 403 | 26 |
| 1977-07-31 | vs BOS | 100 | L 0-1 | 47-53 | 5 | 19,514 | Frank Tanana | Don Aase | Don Aase | Dave LaRoche | | 429 | 404 | 25 |
| 1977-08-01 | vs NYA | 101 | W 4-1 | 48-53 | 5 | 34,852 | Ken Brett | Catfish Hunter | Ken Brett | Catfish Hunter | | 433 | 405 | 28 |
| 1977-08-02 | vs NYA | 102 | L 3-9 | 48-54 | 5 | 20,298 | Paul Hartzell | Mike Torrez | Mike Torrez | Paul Hartzell | | 436 | 414 | 22 |
| 1977-08-03 | vs NYA | 103 | W 5-3 | 49-54 | 5 | 26,187 | Nolan Ryan | Ron Guidry | Nolan Ryan | Ron Guidry | Dave LaRoche | 441 | 417 | 24 |
| 1977-08-05 | vs BAL | 104 | W 5-0 | 50-54 | 5 | 18,078 | Frank Tanana | Ross Grimsley | Frank Tanana | Ross Grimsley | | 446 | 417 | 29 |
| 1977-08-06 | vs BAL | 105 | W 9-5 | 51-54 | 5 | 20,859 | Ken Brett | Rudy May | Ken Brett | Rudy May | | 455 | 422 | 33 |
| 1977-08-07 | vs BAL | 106 | W 6-3 | 52-54 | 5 | 15,729 | Paul Hartzell | Jim Palmer | Dave LaRoche | Jim Palmer | Dyar Miller | 461 | 425 | 36 |
| 1977-08-08 | @ KCA | 107 | W 6-4 | 54-54 | 5 | 0 | Nolan Ryan | Andy Hassler | Nolan Ryan | Andy Hassler | Dave LaRoche | 467 | 429 | 38 |
| 1977-08-08 | @ KCA | 108 | W 7-2 | 54-54 | 5 | 40,525 | Wayne Simpson | Paul Splittorff | Wayne Simpson | Paul Splittorff | | 474 | 431 | 43 |
| 1977-08-10 | @ BOS | 109 | L 10-11 | 54-55 | 5 | 34,869 | Frank Tanana | Luis Tiant | Jim Willoughby | Dyar Miller | | 484 | 442 | 42 |
| 1977-08-11 | @ BOS | 110 | W 7-3 | 55-55 | 5 | 35,691 | Paul Hartzell | Don Aase | Paul Hartzell | Don Aase | | 491 | 445 | 46 |
| 1977-08-12 | @ NYA | 111 | L 1-10 | 55-57 | 5 | 33,473 | Ken Brett | Catfish Hunter | Catfish Hunter | Ken Brett | | 492 | 455 | 37 |
| 1977-08-12 | @ NYA | 112 | L 3-9 | 55-57 | 5 | 33,473 | Fred Kuhaulua | Ed Figueroa | Ed Figueroa | Mike Barlow | | 495 | 464 | 31 |
| 1977-08-13 | @ NYA | 113 | W 6-5 | 56-57 | 5 | 44,520 | Nolan Ryan | Ken Holtzman | Nolan Ryan | Sparky Lyle | Mike Barlow | 501 | 469 | 32 |
| 1977-08-14 | @ NYA | 114 | L 3-15 | 56-58 | 5 | 31,448 | Wayne Simpson | Dick Tidrow | Dick Tidrow | Wayne Simpson | Gil Patterson | 504 | 484 | 20 |
| 1977-08-15 | @ TOR | 115 | W 7-4 | 57-58 | 5 | 18,453 | Frank Tanana | Jesse Jefferson | Frank Tanana | Jesse Jefferson | | 511 | 488 | 23 |
| 1977-08-16 | @ TOR | 116 | W 7-2 | 58-58 | 5 | 15,424 | Paul Hartzell | Jeff Byrd | Paul Hartzell | Jeff Byrd | | 518 | 490 | 28 |
| 1977-08-19 | vs TOR | 117 | L 1-3 | 58-59 | 5 | 16,570 | Nolan Ryan | Jerry Garvin | Jerry Garvin | Nolan Ryan | Pete Vuckovich | 519 | 493 | 26 |
| 1977-08-20 | vs TOR | 118 | L 4-5 | 58-60 | 5 | 15,311 | Ken Brett | Jesse Jefferson | Pete Vuckovich | Dave LaRoche | | 523 | 498 | 25 |
| 1977-08-21 | vs TOR | 119 | W 3-2 | 59-60 | 5 | 12,421 | Frank Tanana | Jeff Byrd | Frank Tanana | Jeff Byrd | | 526 | 500 | 26 |
| 1977-08-22 | vs DET | 120 | L 1-5 | 59-61 | 5 | 24,304 | Paul Hartzell | Fernando Arroyo | Fernando Arroyo | Paul Hartzell | | 527 | 505 | 22 |
| 1977-08-23 | vs DET | 121 | L 1-3 | 59-62 | 5 | 13,875 | Wayne Simpson | Bob Sykes | Bob Sykes | Wayne Simpson | Steve Foucault | 528 | 508 | 20 |
| 1977-08-24 | vs CLE | 122 | L 3-5 | 60-63 | 5 | 0 | Nolan Ryan | Al Fitzmorris | Al Fitzmorris | Nolan Ryan | Jim Kern | 531 | 513 | 18 |
| 1977-08-24 | vs CLE | 123 | W 5-2 | 60-63 | 5 | 16,394 | Ken Brett | Rick Waits | Ken Brett | Rick Waits | Dave LaRoche | 536 | 515 | 21 |
| 1977-08-26 | @ DET | 124 | W 7-4 | 61-63 | 5 | 22,602 | Frank Tanana | Jack Morris | Dave LaRoche | Steve Foucault | | 543 | 519 | 24 |
| 1977-08-27 | @ DET | 125 | L 6-7 | 61-64 | 5 | 23,105 | Paul Hartzell | Fernando Arroyo | John Hiller | Dave LaRoche | | 549 | 526 | 23 |
| 1977-08-28 | @ DET | 126 | L 9-12 | 61-65 | 5 | 14,985 | Gary Nolan | Bob Sykes | Steve Foucault | Dyar Miller | | 558 | 538 | 20 |
| 1977-08-29 | @ BAL | 127 | L 1-6 | 61-66 | 5 | 10,103 | Nolan Ryan | Rudy May | Rudy May | Nolan Ryan | | 559 | 544 | 15 |
| 1977-08-30 | @ BAL | 128 | L 2-8 | 61-67 | 5 | 7,583 | Ken Brett | Jim Palmer | Jim Palmer | Ken Brett | | 561 | 552 | 9 |
| 1977-08-31 | @ BAL | 129 | L 3-4 | 61-68 | 5 | 9,416 | Frank Tanana | Dennis Martinez | Dennis Martinez | Frank Tanana | | 564 | 556 | 8 |
| 1977-09-02 | @ CLE | 130 | L 1-3 | 61-69 | 5 | 5,349 | Paul Hartzell | Jim Bibby | Jim Bibby | Paul Hartzell | Jim Kern | 565 | 559 | 6 |
| 1977-09-03 | @ CLE | 131 | W 3-2 | 62-69 | 5 | 11,054 | Nolan Ryan | Wayne Garland | Nolan Ryan | Wayne Garland | | 568 | 561 | 7 |
| 1977-09-04 | @ CLE | 132 | W 7-3 | 63-69 | 5 | 7,580 | Ken Brett | Al Fitzmorris | Ken Brett | Al Fitzmorris | | 575 | 564 | 11 |
| 1977-09-05 | vs MIL | 133 | L 5-6 | 63-70 | 5 | 10,575 | Frank Tanana | Jim Slaton | Jim Slaton | Frank Tanana | Eduardo Rodriguez | 580 | 570 | 10 |
| 1977-09-07 | vs MIL | 134 | W 4-1 | 64-70 | 5 | 10,066 | Paul Hartzell | Jerry Augustine | Paul Hartzell | Jerry Augustine | | 584 | 571 | 13 |
| 1977-09-08 | vs CHA | 135 | W 2-0 | 66-70 | 5 | 0 | Nolan Ryan | Francisco Barrios | Nolan Ryan | Francisco Barrios | Dave LaRoche | 586 | 571 | 15 |
| 1977-09-08 | vs CHA | 136 | W 3-2 | 66-70 | 5 | 15,045 | Gary Nolan | Ken Kravec | Mike Barlow | Clay Carroll | | 589 | 573 | 16 |
| 1977-09-09 | vs CHA | 137 | L 1-4 | 66-71 | 5 | 21,308 | Ken Brett | Steve Stone | Steve Stone | Ken Brett | Lerrin LaGrow | 590 | 577 | 13 |
| 1977-09-10 | vs CHA | 138 | W 6-1 | 67-71 | 5 | 10,659 | John Caneira | Wilbur Wood | John Caneira | Wilbur Wood | | 596 | 578 | 18 |
| 1977-09-11 | vs CHA | 139 | L 2-6 | 68-72 | 5 | 0 | Paul Hartzell | Chris Knapp | Chris Knapp | Paul Hartzell | | 598 | 584 | 14 |
| 1977-09-11 | vs CHA | 140 | W 5-4 | 68-72 | 5 | 16,147 | Wayne Simpson | Dave Frost | Mike Barlow | Silvio Martinez | Dave LaRoche | 603 | 588 | 15 |
| 1977-09-12 | @ TEX | 141 | L 2-3 | 68-73 | 5 | 5,258 | Nolan Ryan | Dock Ellis | Dock Ellis | Nolan Ryan | Len Barker | 605 | 591 | 14 |
| 1977-09-13 | @ TEX | 142 | W 12-7 | 69-73 | 5 | 5,922 | Balor Moore | Gaylord Perry | Mike Barlow | Jim Umbarger | | 617 | 598 | 19 |
| 1977-09-14 | @ TEX | 143 | L 1-2 | 69-74 | 5 | 4,538 | Ken Brett | Doyle Alexander | Doyle Alexander | Ken Brett | | 618 | 600 | 18 |
| 1977-09-15 | @ TEX | 144 | L 4-6 | 69-75 | 5 | 5,497 | John Caneira | Nelson Briles | Nelson Briles | John Caneira | Adrian Devine | 622 | 606 | 16 |
| 1977-09-16 | @ CHA | 145 | W 4-1 | 70-75 | 5 | 18,585 | Paul Hartzell | Chris Knapp | Paul Hartzell | Chris Knapp | | 626 | 607 | 19 |
| 1977-09-17 | @ CHA | 146 | W 4-3 | 71-75 | 5 | 15,378 | Wayne Simpson | Steve Renko | Dyar Miller | Dave Hamilton | Dave LaRoche | 630 | 610 | 20 |
| 1977-09-18 | @ CHA | 147 | L 3-6 | 71-77 | 5 | 0 | Gary Nolan | Francisco Barrios | Francisco Barrios | Gary Nolan | Lerrin LaGrow | 633 | 616 | 17 |
| 1977-09-18 | @ CHA | 148 | L 3-7 | 71-77 | 5 | 22,215 | Balor Moore | Dave Frost | Dave Frost | Balor Moore | | 636 | 623 | 13 |
| 1977-09-19 | vs TEX | 149 | L 1-6 | 71-78 | 5 | 26,718 | Nolan Ryan | Doyle Alexander | Doyle Alexander | Nolan Ryan | | 637 | 629 | 8 |
| 1977-09-20 | vs TEX | 150 | W 5-2 | 72-78 | 5 | 9,415 | Ken Brett | Paul Lindblad | Ken Brett | Paul Lindblad | | 642 | 631 | 11 |
| 1977-09-21 | vs TEX | 151 | L 1-9 | 72-79 | 5 | 8,426 | John Caneira | Dock Ellis | Dock Ellis | John Caneira | | 643 | 640 | 3 |
| 1977-09-22 | vs TEX | 152 | L 0-6 | 72-80 | 5 | 8,031 | Paul Hartzell | Bert Blyleven | Bert Blyleven | Paul Hartzell | | 643 | 646 | -3 |
| 1977-09-23 | vs KCA | 153 | L 3-7 | 72-81 | 5 | 10,888 | Wayne Simpson | Dennis Leonard | Dennis Leonard | Wayne Simpson | | 646 | 653 | -7 |
| 1977-09-24 | vs KCA | 154 | L 3-4 | 72-82 | 5 | 8,989 | Balor Moore | Mark Littell | Mark Littell | Balor Moore | Doug Bird | 649 | 657 | -8 |
| 1977-09-25 | vs KCA | 155 | L 3-6 | 72-84 | 5 | 0 | Ken Brett | Paul Splittorff | Paul Splittorff | Ken Brett | George Throop | 652 | 663 | -11 |
| 1977-09-25 | vs KCA | 156 | L 2-6 | 72-84 | 5 | 22,943 | Nolan Ryan | Marty Pattin | Marty Pattin | Nolan Ryan | | 654 | 669 | -15 |
| 1977-09-27 | @ MIL | 157 | L 5-7 | 72-85 | 5 | 3,142 | Paul Hartzell | Jim Slaton | Eduardo Rodriguez | Dave LaRoche | | 659 | 676 | -17 |
| 1977-09-28 | @ MIL | 158 | W 4-2 | 73-85 | 5 | 3,176 | John Caneira | Jerry Augustine | John Caneira | Jerry Augustine | Dyar Miller | 663 | 678 | -15 |
| 1977-09-29 | @ KCA | 159 | L 3-6 | 73-86 | 5 | 14,334 | Wayne Simpson | Larry Gura | Larry Gura | Wayne Simpson | Doug Bird | 666 | 684 | -18 |
| 1977-09-30 | @ KCA | 160 | L 5-8 | 73-87 | 5 | 33,289 | Ken Brett | Paul Splittorff | Marty Pattin | Ken Brett | | 671 | 692 | -21 |
| 1977-10-01 | @ KCA | 161 | W 4-1 | 74-87 | 5 | 23,497 | Mike Barlow | Andy Hassler | Mike Barlow | Andy Hassler | Dave LaRoche | 675 | 693 | -18 |
| 1977-10-02 | @ KCA | 162 | L 0-2 | 74-88 | 5 | 22,404 | Paul Hartzell | Dennis Leonard | Dennis Leonard | Paul Hartzell | | 675 | 695 | -20 |