| 1977-04-07 | vs CHA | 1 | W 9-5 | 1-0 | 3 | 44,649 | Bill Singer | Ken Brett | Jerry Johnson | Ken Brett | Pete Vuckovich | 9 | 5 | 4 |
| 1977-04-09 | vs CHA | 2 | L 2-3 | 1-1 | 4 | 18,214 | Dave Lemanczyk | Chris Knapp | Chris Knapp | Dave Lemanczyk | Lerrin LaGrow | 11 | 8 | 3 |
| 1977-04-10 | vs CHA | 3 | W 3-1 | 2-1 | 3 | 17,059 | Jerry Garvin | Steve Stone | Jerry Garvin | Steve Stone | Pete Vuckovich | 14 | 9 | 5 |
| 1977-04-11 | vs DET | 4 | W 5-3 | 3-1 | 1 | 29,132 | Jesse Jefferson | Dave Rozema | Steve Hargan | John Hiller | | 19 | 12 | 7 |
| 1977-04-12 | vs DET | 5 | L 1-6 | 3-2 | 2 | 11,505 | Bill Singer | Dave Roberts | Dave Roberts | Bill Singer | | 20 | 18 | 2 |
| 1977-04-13 | vs DET | 6 | W 7-6 | 4-2 | 2 | 12,113 | Dave Lemanczyk | Bob Sykes | Dave Lemanczyk | Fernando Arroyo | Mike Willis | 27 | 24 | 3 |
| 1977-04-14 | vs DET | 7 | W 5-3 | 5-2 | 2 | 13,369 | Jerry Garvin | Ray Bare | Jerry Garvin | John Hiller | | 32 | 27 | 5 |
| 1977-04-15 | @ CHA | 8 | L 5-7 | 5-3 | 3 | 10,840 | Steve Hargan | Chris Knapp | Francisco Barrios | Jerry Johnson | | 37 | 34 | 3 |
| 1977-04-16 | @ CHA | 9 | L 2-3 | 5-4 | 3 | 7,467 | Jesse Jefferson | Steve Stone | Steve Stone | Pete Vuckovich | | 39 | 37 | 2 |
| 1977-04-17 | @ CHA | 10 | L 2-4 | 5-5 | 3 | 14,583 | Bill Singer | Ken Brett | Ken Brett | Bill Singer | Bruce Dal Canton | 41 | 41 | 0 |
| 1977-04-18 | @ NYA | 11 | W 5-1 | 6-5 | 2 | 9,685 | Dave Lemanczyk | Ed Figueroa | Dave Lemanczyk | Ed Figueroa | | 46 | 42 | 4 |
| 1977-04-19 | @ NYA | 12 | W 8-3 | 7-5 | 2 | 9,954 | Jerry Garvin | Gil Patterson | Jerry Garvin | Gil Patterson | | 54 | 45 | 9 |
| 1977-04-20 | @ NYA | 13 | L 5-7 | 7-6 | 3 | 10,819 | Steve Hargan | Don Gullett | Don Gullett | Steve Hargan | Sparky Lyle | 59 | 52 | 7 |
| 1977-04-21 | @ NYA | 14 | L 6-8 | 7-7 | 3 | 10,502 | Jesse Jefferson | Ken Holtzman | Ken Holtzman | Chuck Hartenstein | Sparky Lyle | 65 | 60 | 5 |
| 1977-04-24 | vs BOS | 15 | L 0-9 | 7-8 | 4 | 29,303 | Bill Singer | Fergie Jenkins | Fergie Jenkins | Bill Singer | | 65 | 69 | -4 |
| 1977-04-25 | vs BOS | 16 | W 4-3 | 8-9 | 4 | 0 | Jerry Garvin | Luis Tiant | Pete Vuckovich | Bill Campbell | | 69 | 72 | -3 |
| 1977-04-25 | vs BOS | 17 | L 5-6 | 8-9 | 4 | 15,016 | Dave Lemanczyk | Bob Stanley | Jim Willoughby | Pete Vuckovich | | 74 | 78 | -4 |
| 1977-04-27 | @ CLE | 18 | W 6-5 | 9-9 | 4 | 3,639 | Steve Hargan | Wayne Garland | Mike Willis | Jim Kern | | 80 | 83 | -3 |
| 1977-04-28 | @ CLE | 19 | L 3-4 | 9-10 | 4 | 2,724 | Jesse Jefferson | Al Fitzmorris | Al Fitzmorris | Jesse Jefferson | Rick Waits | 83 | 87 | -4 |
| 1977-04-29 | @ KCA | 20 | L 1-6 | 9-11 | 5 | 15,523 | Bill Singer | Jim Colborn | Jim Colborn | Bill Singer | | 84 | 93 | -9 |
| 1977-04-30 | @ KCA | 21 | W 2-1 | 10-11 | 5 | 15,301 | Jerry Garvin | Paul Splittorff | Jerry Garvin | Paul Splittorff | | 86 | 94 | -8 |
| 1977-05-01 | @ KCA | 22 | L 2-8 | 10-12 | 5 | 34,066 | Dave Lemanczyk | Larry Gura | Larry Gura | Dave Lemanczyk | Mark Littell | 88 | 102 | -14 |
| 1977-05-02 | vs MIL | 23 | L 1-3 | 10-13 | 5 | 17,577 | Steve Hargan | Moose Haas | Moose Haas | Steve Hargan | Bill Castro | 89 | 105 | -16 |
| 1977-05-03 | vs MIL | 24 | L 2-6 | 10-14 | 5 | 13,148 | Jesse Jefferson | Barry Cort | Barry Cort | Jesse Jefferson | | 91 | 111 | -20 |
| 1977-05-04 | vs MIL | 25 | W 10-3 | 11-14 | 5 | 25,699 | Bill Singer | Jim Slaton | Bill Singer | Jim Slaton | Mike Willis | 101 | 114 | -13 |
| 1977-05-05 | vs MIL | 26 | W 9-8 | 12-14 | 5 | 12,268 | Jerry Garvin | Gary Beare | Pete Vuckovich | Bill Castro | | 110 | 122 | -12 |
| 1977-05-06 | vs MIN | 27 | L 2-7 | 12-15 | 5 | 26,355 | Dave Lemanczyk | Geoff Zahn | Geoff Zahn | Dave Lemanczyk | Ron Schueler | 112 | 129 | -17 |
| 1977-05-07 | vs MIN | 28 | L 1-4 | 12-16 | 5 | 34,091 | Steve Hargan | Paul Thormodsgard | Paul Thormodsgard | Steve Hargan | Tom Johnson | 113 | 133 | -20 |
| 1977-05-08 | vs MIN | 29 | L 4-5 | 12-17 | 5 | 20,902 | Jesse Jefferson | Dave Goltz | Dave Goltz | Jesse Jefferson | Tom Johnson | 117 | 138 | -21 |
| 1977-05-09 | vs SEA | 30 | W 10-4 | 13-17 | 5 | 11,680 | Bill Singer | Stan Thomas | Bill Singer | Stan Thomas | | 127 | 142 | -15 |
| 1977-05-10 | vs SEA | 31 | W 9-3 | 14-17 | 5 | 13,017 | Jerry Garvin | John Montague | Jerry Garvin | John Montague | | 136 | 145 | -9 |
| 1977-05-13 | @ MIN | 32 | L 3-4 | 14-18 | 5 | 9,667 | Dave Lemanczyk | Paul Thormodsgard | Ron Schueler | Mike Willis | | 139 | 149 | -10 |
| 1977-05-14 | @ MIN | 33 | L 3-13 | 14-19 | 6 | 10,503 | Bill Singer | Dave Goltz | Dave Goltz | Bill Singer | | 142 | 162 | -20 |
| 1977-05-15 | @ MIN | 34 | L 3-5 | 14-20 | 6 | 11,401 | Jerry Garvin | Pete Redfern | Tom Burgmeier | Jerry Garvin | Ron Schueler | 145 | 167 | -22 |
| 1977-05-17 | @ MIL | 35 | W 3-1 | 15-20 | 5 | 6,810 | Jesse Jefferson | Moose Haas | Jesse Jefferson | Moose Haas | Jerry Johnson | 148 | 168 | -20 |
| 1977-05-18 | @ MIL | 36 | L 2-3 | 15-21 | 5 | 7,208 | Dave Lemanczyk | Barry Cort | Bill Castro | Pete Vuckovich | | 150 | 171 | -21 |
| 1977-05-19 | @ MIL | 37 | L 3-5 | 15-22 | 6 | 8,469 | Bill Singer | Jim Slaton | Jim Slaton | Bill Singer | Bob McClure | 153 | 176 | -23 |
| 1977-05-20 | @ TEX | 38 | W 4-3 | 16-22 | 6 | 21,965 | Jerry Garvin | Bert Blyleven | Jerry Garvin | Bert Blyleven | | 157 | 179 | -22 |
| 1977-05-21 | @ TEX | 39 | W 9-6 | 17-22 | 6 | 20,351 | Jesse Jefferson | Nelson Briles | Jesse Jefferson | Nelson Briles | Mike Willis | 166 | 185 | -19 |
| 1977-05-22 | @ TEX | 40 | L 4-7 | 17-23 | 6 | 21,831 | Dave Lemanczyk | Doyle Alexander | Doyle Alexander | Dave Lemanczyk | Darold Knowles | 170 | 192 | -22 |
| 1977-05-23 | vs OAK | 41 | L 0-3 | 17-24 | 6 | 27,705 | Pete Vuckovich | Rick Langford | Rick Langford | Pete Vuckovich | | 170 | 195 | -25 |
| 1977-05-25 | vs OAK | 42 | L 5-6 | 17-25 | 7 | 36,097 | Jerry Garvin | Jim Umbarger | Dave Giusti | Jerry Garvin | | 175 | 201 | -26 |
| 1977-05-27 | vs CAL | 43 | L 1-4 | 17-26 | 7 | 24,779 | Bill Singer | Gary Ross | Gary Ross | Jerry Johnson | Paul Hartzell | 176 | 205 | -29 |
| 1977-05-28 | vs CAL | 44 | W 6-4 | 18-26 | 7 | 30,034 | Jesse Jefferson | Wayne Simpson | Jesse Jefferson | Wayne Simpson | Pete Vuckovich | 182 | 209 | -27 |
| 1977-05-29 | vs CAL | 45 | L 2-3 | 18-27 | 7 | 30,009 | Dave Lemanczyk | Nolan Ryan | Nolan Ryan | Dave Lemanczyk | | 184 | 212 | -28 |
| 1977-05-30 | vs KCA | 46 | L 1-4 | 18-28 | 7 | 20,002 | Jerry Garvin | Paul Splittorff | Paul Splittorff | Jerry Garvin | Mark Littell | 185 | 216 | -31 |
| 1977-06-01 | vs KCA | 47 | L 3-11 | 18-29 | 7 | 33,004 | Bill Singer | Dennis Leonard | Dennis Leonard | Bill Singer | | 188 | 227 | -39 |
| 1977-06-03 | @ OAK | 48 | L 2-3 | 18-30 | 7 | 3,030 | Jesse Jefferson | Rick Langford | Bob Lacey | Jesse Jefferson | | 190 | 230 | -40 |
| 1977-06-04 | @ OAK | 49 | W 4-2 | 19-30 | 7 | 4,525 | Dave Lemanczyk | Dock Ellis | Dave Lemanczyk | Dock Ellis | Pete Vuckovich | 194 | 232 | -38 |
| 1977-06-05 | @ OAK | 50 | W 7-3 | 20-30 | 7 | 4,580 | Jerry Garvin | Vida Blue | Jerry Garvin | Vida Blue | Jerry Johnson | 201 | 235 | -34 |
| 1977-06-07 | @ CAL | 51 | W 6-3 | 21-30 | 7 | 10,239 | Pete Vuckovich | Paul Hartzell | Mike Willis | Paul Hartzell | | 207 | 238 | -31 |
| 1977-06-08 | @ CAL | 52 | L 1-2 | 21-31 | 7 | 11,678 | Jesse Jefferson | Nolan Ryan | Dave LaRoche | Tom Bruno | | 208 | 240 | -32 |
| 1977-06-10 | @ SEA | 53 | W 4-3 | 22-31 | 7 | 11,786 | Dave Lemanczyk | John Montague | Dave Lemanczyk | John Montague | Mike Willis | 212 | 243 | -31 |
| 1977-06-11 | @ SEA | 54 | W 5-4 | 23-31 | 7 | 21,318 | Jerry Garvin | Glenn Abbott | Jerry Johnson | Enrique Romo | | 217 | 247 | -30 |
| 1977-06-12 | @ SEA | 55 | L 2-5 | 23-32 | 7 | 28,412 | Pete Vuckovich | Dick Pole | Dick Pole | Pete Vuckovich | | 219 | 252 | -33 |
| 1977-06-14 | @ DET | 56 | L 2-7 | 23-33 | 7 | 11,808 | Jesse Jefferson | John Hiller | John Hiller | Jesse Jefferson | | 221 | 259 | -38 |
| 1977-06-15 | @ DET | 57 | L 0-9 | 23-34 | 7 | 11,349 | Dave Lemanczyk | Fernando Arroyo | Fernando Arroyo | Dave Lemanczyk | | 221 | 268 | -47 |
| 1977-06-16 | @ DET | 58 | L 1-4 | 23-35 | 7 | 26,041 | Jerry Garvin | Mark Fidrych | Mark Fidrych | Jerry Garvin | | 222 | 272 | -50 |
| 1977-06-17 | vs BAL | 59 | L 3-5 | 23-36 | 7 | 26,183 | Pete Vuckovich | Ross Grimsley | Dennis Martinez | Pete Vuckovich | | 225 | 277 | -52 |
| 1977-06-18 | vs BAL | 60 | L 2-4 | 23-37 | 7 | 33,201 | Jesse Jefferson | Jim Palmer | Jim Palmer | Jesse Jefferson | Tippy Martinez | 227 | 281 | -54 |
| 1977-06-19 | vs BAL | 61 | W 7-1 | 24-37 | 7 | 34,556 | Dave Lemanczyk | Mike Flanagan | Dave Lemanczyk | Mike Flanagan | | 234 | 282 | -48 |
| 1977-06-20 | vs CLE | 62 | L 5-8 | 24-38 | 7 | 24,568 | Jeff Byrd | Al Fitzmorris | Pat Dobson | Mike Willis | Jim Kern | 239 | 290 | -51 |
| 1977-06-21 | vs CLE | 63 | L 0-4 | 24-39 | 7 | 18,039 | Jerry Garvin | Rick Waits | Rick Waits | Jerry Garvin | Jim Kern | 239 | 294 | -55 |
| 1977-06-22 | vs CLE | 64 | L 5-7 | 24-40 | 7 | 29,750 | Pete Vuckovich | Dennis Eckersley | Jim Kern | Jerry Johnson | Sid Monge | 244 | 301 | -57 |
| 1977-06-23 | vs CLE | 65 | L 0-4 | 24-41 | 7 | 16,747 | Jesse Jefferson | Wayne Garland | Wayne Garland | Jesse Jefferson | | 244 | 305 | -61 |
| 1977-06-24 | @ BAL | 66 | W 5-4 | 25-41 | 7 | 8,133 | Dave Lemanczyk | Rudy May | Dave Lemanczyk | Fred Holdsworth | Mike Willis | 249 | 309 | -60 |
| 1977-06-25 | @ BAL | 67 | L 2-5 | 25-43 | 7 | 16,794 | Jeff Byrd | Dennis Martinez | Dennis Martinez | Jeff Byrd | | 251 | 314 | -63 |
| 1977-06-25 | @ BAL | 68 | L 1-3 | 25-43 | 7 | 16,794 | Jerry Garvin | Ross Grimsley | Ross Grimsley | Jerry Garvin | | 252 | 317 | -65 |
| 1977-06-26 | @ BAL | 69 | W 2-0 | 26-43 | 7 | 16,761 | Pete Vuckovich | Jim Palmer | Pete Vuckovich | Jim Palmer | | 254 | 317 | -63 |
| 1977-06-27 | vs NYA | 70 | W 7-6 | 27-43 | 7 | 29,138 | Jesse Jefferson | Ron Guidry | Jesse Jefferson | Ron Guidry | Jerry Johnson | 261 | 323 | -62 |
| 1977-06-28 | vs NYA | 71 | W 8-5 | 28-44 | 7 | 40,116 | Dave Lemanczyk | Ken Clay | Dave Lemanczyk | Ken Clay | | 269 | 328 | -59 |
| 1977-06-28 | vs NYA | 72 | L 1-5 | 28-44 | 7 | 40,116 | Mike Willis | Ken Holtzman | Dick Tidrow | Jerry Johnson | | 270 | 333 | -63 |
| 1977-06-30 | vs NYA | 73 | L 5-11 | 28-45 | 7 | 33,283 | Jerry Garvin | Catfish Hunter | Catfish Hunter | Jerry Garvin | | 275 | 344 | -69 |
| 1977-07-01 | vs TEX | 74 | L 8-11 | 28-46 | 7 | 21,089 | Jeff Byrd | Doyle Alexander | Doyle Alexander | Jeff Byrd | Adrian Devine | 283 | 355 | -72 |
| 1977-07-02 | vs TEX | 75 | W 10-7 | 29-46 | 7 | 19,176 | Pete Vuckovich | Len Barker | Pete Vuckovich | Len Barker | | 293 | 362 | -69 |
| 1977-07-03 | vs TEX | 76 | L 3-6 | 30-47 | 7 | 0 | Dave Lemanczyk | Dock Ellis | Dock Ellis | Mike Willis | Darold Knowles | 296 | 368 | -72 |
| 1977-07-03 | vs TEX | 77 | W 5-3 | 30-47 | 7 | 32,066 | Jesse Jefferson | Roger Moret | Jesse Jefferson | Darold Knowles | | 301 | 371 | -70 |
| 1977-07-04 | @ BOS | 78 | L 6-9 | 30-48 | 7 | 21,073 | Jerry Garvin | Fergie Jenkins | Bill Campbell | Chuck Hartenstein | | 307 | 380 | -73 |
| 1977-07-06 | @ BOS | 79 | L 5-9 | 30-49 | 7 | 34,956 | Pete Vuckovich | Luis Tiant | Bill Campbell | Pete Vuckovich | | 312 | 389 | -77 |
| 1977-07-07 | @ BOS | 80 | L 2-5 | 30-50 | 7 | 32,641 | Jesse Jefferson | Bob Stanley | Bob Stanley | Jesse Jefferson | Bill Campbell | 314 | 394 | -80 |
| 1977-07-08 | @ CLE | 81 | L 5-11 | 30-51 | 7 | 12,719 | Dave Lemanczyk | Dennis Eckersley | Dennis Eckersley | Dave Lemanczyk | | 319 | 405 | -86 |
| 1977-07-09 | @ CLE | 82 | L 2-3 | 30-52 | 7 | 19,594 | Jerry Garvin | Wayne Garland | Wayne Garland | Jerry Garvin | | 321 | 408 | -87 |
| 1977-07-10 | @ CLE | 83 | W 5-3 | 31-52 | 7 | 12,935 | Jeff Byrd | Pat Dobson | Jeff Byrd | Pat Dobson | Pete Vuckovich | 326 | 411 | -85 |
| 1977-07-11 | @ DET | 84 | L 7-9 | 31-53 | 7 | 9,057 | Mike Willis | Dave Roberts | Steve Grilli | Dennis DeBarr | | 333 | 420 | -87 |
| 1977-07-12 | @ DET | 85 | L 1-2 | 31-54 | 7 | 25,007 | Jesse Jefferson | Mark Fidrych | Jim Crawford | Jesse Jefferson | | 334 | 422 | -88 |
| 1977-07-13 | @ CHA | 86 | L 3-6 | 32-55 | 7 | 0 | Bill Singer | Chris Knapp | Chris Knapp | Bill Singer | Bart Johnson | 337 | 428 | -91 |
| 1977-07-13 | @ CHA | 87 | W 5-3 | 32-55 | 7 | 25,669 | Dave Lemanczyk | Jack Kucek | Dave Lemanczyk | Jack Kucek | | 342 | 431 | -89 |
| 1977-07-14 | @ CHA | 88 | L 1-2 | 32-56 | 7 | 15,937 | Jerry Garvin | Ken Kravec | Ken Kravec | Jerry Garvin | | 343 | 433 | -90 |
| 1977-07-15 | vs DET | 89 | W 8-6 | 33-56 | 7 | 23,749 | Jeff Byrd | Dave Roberts | Pete Vuckovich | Jim Crawford | | 351 | 439 | -88 |
| 1977-07-16 | vs DET | 90 | L 3-11 | 33-57 | 7 | 35,151 | Mike Willis | Dave Rozema | Dave Rozema | Mike Willis | | 354 | 450 | -96 |
| 1977-07-17 | vs DET | 91 | W 3-2 | 34-58 | 7 | 0 | Jesse Jefferson | Fernando Arroyo | Jesse Jefferson | Fernando Arroyo | | 357 | 452 | -95 |
| 1977-07-17 | vs DET | 92 | L 6-7 | 34-58 | 7 | 36,613 | Dave Lemanczyk | Milt Wilcox | John Hiller | Dave Lemanczyk | | 363 | 459 | -96 |
| 1977-07-22 | vs CHA | 93 | L 3-10 | 34-59 | 7 | 33,175 | Jerry Garvin | Wilbur Wood | Wilbur Wood | Jerry Garvin | Lerrin LaGrow | 366 | 469 | -103 |
| 1977-07-23 | vs CHA | 94 | L 3-10 | 34-60 | 7 | 24,263 | Dave Lemanczyk | Ken Kravec | Ken Kravec | Dave Lemanczyk | | 369 | 479 | -110 |
| 1977-07-24 | @ DET | 95 | L 2-6 | 34-61 | 7 | 20,177 | Jesse Jefferson | Bob Sykes | Bob Sykes | Jesse Jefferson | | 371 | 485 | -114 |
| 1977-07-25 | @ DET | 96 | L 3-8 | 34-62 | 7 | 16,911 | Jeff Byrd | Milt Wilcox | Milt Wilcox | Jeff Byrd | Jim Crawford | 374 | 493 | -119 |
| 1977-07-26 | vs TEX | 97 | L 0-14 | 34-63 | 7 | 22,357 | Jim Clancy | Bert Blyleven | Bert Blyleven | Jim Clancy | | 374 | 507 | -133 |
| 1977-07-28 | vs TEX | 98 | L 0-3 | 34-64 | 7 | 17,512 | Jerry Garvin | Gaylord Perry | Gaylord Perry | Jerry Garvin | | 374 | 510 | -136 |
| 1977-07-29 | vs MIL | 99 | L 3-7 | 34-65 | 7 | 14,303 | Jesse Jefferson | Moose Haas | Moose Haas | Jesse Jefferson | | 377 | 517 | -140 |
| 1977-07-30 | vs MIL | 100 | L 2-3 | 34-66 | 7 | 18,639 | Jeff Byrd | Jim Slaton | Jim Slaton | Jeff Byrd | | 379 | 520 | -141 |
| 1977-07-31 | vs MIL | 101 | W 4-1 | 35-66 | 7 | 28,110 | Dave Lemanczyk | Jerry Augustine | Dave Lemanczyk | Jerry Augustine | Tom Murphy | 383 | 521 | -138 |
| 1977-08-01 | vs MIL | 102 | W 3-2 | 36-66 | 7 | 17,590 | Jim Clancy | Lary Sorensen | Jim Clancy | Lary Sorensen | | 386 | 523 | -137 |
| 1977-08-03 | @ KCA | 103 | L 4-7 | 36-67 | 7 | 16,775 | Jerry Garvin | Paul Splittorff | Paul Splittorff | Jerry Garvin | Doug Bird | 390 | 530 | -140 |
| 1977-08-04 | @ KCA | 104 | L 0-8 | 36-68 | 7 | 17,661 | Jesse Jefferson | Larry Gura | Larry Gura | Jesse Jefferson | | 390 | 538 | -148 |
| 1977-08-05 | @ MIL | 105 | W 6-1 | 37-68 | 7 | 13,609 | Jeff Byrd | Jim Slaton | Jeff Byrd | Jim Slaton | | 396 | 539 | -143 |
| 1977-08-06 | @ MIL | 106 | W 5-3 | 38-68 | 7 | 12,720 | Dave Lemanczyk | Jerry Augustine | Dave Lemanczyk | Jerry Augustine | Jerry Johnson | 401 | 542 | -141 |
| 1977-08-07 | @ MIL | 107 | L 2-6 | 38-70 | 7 | 0 | Jerry Garvin | Lary Sorensen | Lary Sorensen | Jerry Garvin | Bob McClure | 403 | 548 | -145 |
| 1977-08-07 | @ MIL | 108 | L 5-7 | 38-70 | 7 | 12,070 | Jim Clancy | Moose Haas | Moose Haas | Jim Clancy | Sam Hinds | 408 | 555 | -147 |
| 1977-08-09 | vs MIN | 109 | W 6-2 | 39-70 | 7 | 23,450 | Jesse Jefferson | Paul Thormodsgard | Jesse Jefferson | Paul Thormodsgard | | 414 | 557 | -143 |
| 1977-08-11 | vs MIN | 110 | L 3-7 | 39-71 | 7 | 18,430 | Jeff Byrd | Dave Goltz | Dave Goltz | Jeff Byrd | Tom Johnson | 417 | 564 | -147 |
| 1977-08-12 | vs KCA | 111 | L 8-9 | 39-72 | 7 | 19,143 | Dave Lemanczyk | Andy Hassler | Marty Pattin | Dave Lemanczyk | Doug Bird | 425 | 573 | -148 |
| 1977-08-13 | vs KCA | 112 | L 3-5 | 39-73 | 7 | 25,027 | Jim Clancy | Paul Splittorff | Paul Splittorff | Jim Clancy | Doug Bird | 428 | 578 | -150 |
| 1977-08-14 | vs KCA | 113 | W 6-3 | 40-73 | 7 | 27,430 | Jerry Garvin | Dennis Leonard | Tom Murphy | Dennis Leonard | Pete Vuckovich | 434 | 581 | -147 |
| 1977-08-15 | vs CAL | 114 | L 4-7 | 40-74 | 7 | 18,453 | Jesse Jefferson | Frank Tanana | Frank Tanana | Jesse Jefferson | | 438 | 588 | -150 |
| 1977-08-16 | vs CAL | 115 | L 2-7 | 40-75 | 7 | 15,424 | Jeff Byrd | Paul Hartzell | Paul Hartzell | Jeff Byrd | | 440 | 595 | -155 |
| 1977-08-17 | @ TEX | 116 | L 5-6 | 40-76 | 7 | 12,913 | Dave Lemanczyk | Nelson Briles | Adrian Devine | Mike Willis | | 445 | 601 | -156 |
| 1977-08-18 | @ TEX | 117 | L 0-8 | 40-77 | 7 | 15,740 | Jim Clancy | Dock Ellis | Dock Ellis | Jim Clancy | | 445 | 609 | -164 |
| 1977-08-19 | @ CAL | 118 | W 3-1 | 41-77 | 7 | 16,570 | Jerry Garvin | Nolan Ryan | Jerry Garvin | Nolan Ryan | Pete Vuckovich | 448 | 610 | -162 |
| 1977-08-20 | @ CAL | 119 | W 5-4 | 42-77 | 7 | 15,311 | Jesse Jefferson | Ken Brett | Pete Vuckovich | Dave LaRoche | | 453 | 614 | -161 |
| 1977-08-21 | @ CAL | 120 | L 2-3 | 42-78 | 7 | 12,421 | Jeff Byrd | Frank Tanana | Frank Tanana | Jeff Byrd | | 455 | 617 | -162 |
| 1977-08-22 | @ OAK | 121 | L 2-5 | 42-79 | 7 | 4,429 | Dave Lemanczyk | Doc Medich | Doc Medich | Dave Lemanczyk | Bob Lacey | 457 | 622 | -165 |
| 1977-08-23 | @ OAK | 122 | W 8-1 | 43-79 | 7 | 3,797 | Jim Clancy | Jim Umbarger | Jim Clancy | Jim Umbarger | | 465 | 623 | -158 |
| 1977-08-24 | @ SEA | 123 | W 7-0 | 45-79 | 7 | 0 | Jerry Garvin | Dick Pole | Jerry Garvin | Dick Pole | | 472 | 623 | -151 |
| 1977-08-24 | @ SEA | 124 | W 9-3 | 45-79 | 7 | 13,253 | Jesse Jefferson | Glenn Abbott | Jesse Jefferson | Glenn Abbott | | 481 | 626 | -145 |
| 1977-08-26 | vs OAK | 125 | L 4-8 | 45-80 | 7 | 22,536 | Jeff Byrd | Rick Langford | Pablo Torrealba | Jeff Byrd | | 485 | 634 | -149 |
| 1977-08-27 | vs OAK | 126 | L 8-9 | 45-81 | 7 | 23,651 | Dave Lemanczyk | Doc Medich | Doc Medich | Dave Lemanczyk | Doug Bair | 493 | 643 | -150 |
| 1977-08-28 | vs OAK | 127 | L 2-6 | 45-82 | 7 | 24,087 | Jim Clancy | Vida Blue | Vida Blue | Jim Clancy | | 495 | 649 | -154 |
| 1977-08-29 | @ MIN | 128 | L 6-7 | 45-84 | 7 | 0 | Jerry Garvin | Pete Redfern | Ron Schueler | Tom Murphy | | 501 | 656 | -155 |
| 1977-08-29 | @ MIN | 129 | L 5-6 | 45-84 | 7 | 10,364 | Jesse Jefferson | Geoff Zahn | Tom Johnson | Mike Willis | | 506 | 662 | -156 |
| 1977-09-02 | vs SEA | 130 | L 3-4 | 45-85 | 7 | 13,502 | Dave Lemanczyk | Glenn Abbott | Glenn Abbott | Dave Lemanczyk | | 509 | 666 | -157 |
| 1977-09-03 | vs SEA | 131 | L 2-6 | 45-86 | 7 | 15,109 | Jesse Jefferson | John Montague | John Montague | Jesse Jefferson | Enrique Romo | 511 | 672 | -161 |
| 1977-09-04 | vs SEA | 132 | L 2-7 | 45-87 | 7 | 17,084 | Jerry Garvin | Paul Mitchell | Paul Mitchell | Jerry Garvin | | 513 | 679 | -166 |
| 1977-09-05 | vs BOS | 133 | L 0-8 | 45-89 | 7 | 0 | Jeff Byrd | Don Aase | Don Aase | Jeff Byrd | | 513 | 687 | -174 |
| 1977-09-05 | vs BOS | 134 | L 0-6 | 45-89 | 7 | 30,373 | Jim Clancy | Reggie Cleveland | Reggie Cleveland | Jim Clancy | | 513 | 693 | -180 |
| 1977-09-06 | vs BOS | 135 | L 2-11 | 45-90 | 7 | 17,666 | Mike Darr | Bill Lee | Bill Lee | Mike Darr | | 515 | 704 | -189 |
| 1977-09-07 | vs BOS | 136 | W 3-2 | 46-90 | 7 | 31,684 | Dave Lemanczyk | Fergie Jenkins | Dave Lemanczyk | Fergie Jenkins | | 518 | 706 | -188 |
| 1977-09-08 | vs BOS | 137 | L 2-7 | 46-91 | 7 | 19,163 | Jesse Jefferson | Mike Paxton | Mike Paxton | Jesse Jefferson | | 520 | 713 | -193 |
| 1977-09-09 | @ NYA | 138 | L 0-2 | 46-92 | 7 | 21,145 | Jerry Garvin | Mike Torrez | Mike Torrez | Jerry Garvin | | 520 | 715 | -195 |
| 1977-09-10 | @ NYA | 139 | W 19-3 | 47-92 | 7 | 20,296 | Jim Clancy | Catfish Hunter | Jim Clancy | Catfish Hunter | | 539 | 718 | -179 |
| 1977-09-11 | @ NYA | 140 | L 3-4 | 48-93 | 7 | 40,905 | Jeff Byrd | Dick Tidrow | Dick Tidrow | Jeff Byrd | Sparky Lyle | 542 | 722 | -180 |
| 1977-09-11 | @ NYA | 141 | W 6-4 | 48-93 | 7 | 40,905 | Tom Murphy | Don Gullett | Tom Murphy | Don Gullett | Jerry Johnson | 548 | 726 | -178 |
| 1977-09-12 | vs BAL | 142 | L 3-6 | 48-94 | 7 | 13,498 | Dave Lemanczyk | Jim Palmer | Jim Palmer | Dave Lemanczyk | Tippy Martinez | 551 | 732 | -181 |
| 1977-09-14 | vs BAL | 143 | L 5-6 | 48-96 | 7 | 19,048 | Jesse Jefferson | Mike Flanagan | Mike Flanagan | Jesse Jefferson | Scott McGregor | 556 | 738 | -182 |
| 1977-09-14 | vs BAL | 144 | L 2-4 | 48-96 | 7 | 19,048 | Jerry Garvin | Rudy May | Rudy May | Jerry Garvin | Scott McGregor | 558 | 742 | -184 |
| 1977-09-15 | vs BAL | 145 | W 4-0 | 49-96 | 7 | 14,015 | Jim Clancy | Ross Grimsley | Jim Clancy | Ross Grimsley | | 562 | 742 | -180 |
| 1977-09-17 | @ CLE | 146 | L 3-6 | 50-97 | 7 | 0 | Jeff Byrd | Dennis Eckersley | Dennis Eckersley | Jeff Byrd | Pat Dobson | 565 | 748 | -183 |
| 1977-09-17 | @ CLE | 147 | W 6-5 | 50-97 | 7 | 5,593 | Dave Lemanczyk | Rick Waits | Dave Lemanczyk | Rick Waits | Tom Murphy | 571 | 753 | -182 |
| 1977-09-18 | @ CLE | 148 | W 7-4 | 51-97 | 7 | 4,376 | Jesse Jefferson | Wayne Garland | Jesse Jefferson | Wayne Garland | Pete Vuckovich | 578 | 757 | -179 |
| 1977-09-19 | @ BAL | 149 | W 3-1 | 52-97 | 7 | 3,325 | Jerry Garvin | Rudy May | Jerry Garvin | Rudy May | | 581 | 758 | -177 |
| 1977-09-20 | @ BAL | 150 | L 2-5 | 52-98 | 7 | 4,301 | Jim Clancy | Jim Palmer | Jim Palmer | Jim Clancy | | 583 | 763 | -180 |
| 1977-09-21 | @ BAL | 151 | L 0-4 | 52-99 | 7 | 4,237 | Jeff Byrd | Ross Grimsley | Ross Grimsley | Jeff Byrd | | 583 | 767 | -184 |
| 1977-09-22 | @ BAL | 152 | L 1-7 | 52-100 | 7 | 9,261 | Dave Lemanczyk | Mike Flanagan | Mike Flanagan | Dave Lemanczyk | | 584 | 774 | -190 |
| 1977-09-23 | vs NYA | 153 | L 3-5 | 52-101 | 7 | 32,590 | Jesse Jefferson | Don Gullett | Don Gullett | Jesse Jefferson | | 587 | 779 | -192 |
| 1977-09-25 | vs NYA | 154 | L 0-15 | 52-103 | 7 | 35,117 | Jerry Garvin | Ron Guidry | Ron Guidry | Jerry Garvin | | 587 | 794 | -207 |
| 1977-09-25 | vs NYA | 155 | L 0-2 | 52-103 | 7 | 35,117 | Jim Clancy | Ed Figueroa | Ed Figueroa | Jim Clancy | Sparky Lyle | 587 | 796 | -209 |
| 1977-09-27 | @ BOS | 156 | L 5-6 | 52-105 | 7 | 0 | Jeff Byrd | Don Aase | Don Aase | Jeff Byrd | Bill Campbell | 592 | 802 | -210 |
| 1977-09-27 | @ BOS | 157 | L 1-5 | 52-105 | 7 | 23,952 | Dave Lemanczyk | Luis Tiant | Luis Tiant | Dave Lemanczyk | Bill Campbell | 593 | 807 | -214 |
| 1977-09-28 | @ BOS | 158 | W 3-2 | 53-105 | 7 | 20,362 | Jesse Jefferson | Bill Lee | Pete Vuckovich | Bill Lee | | 596 | 809 | -213 |
| 1977-09-29 | @ BOS | 159 | L 3-7 | 53-106 | 7 | 12,240 | Jerry Garvin | Mike Paxton | Bob Stanley | Jerry Garvin | | 599 | 816 | -217 |
| 1977-10-02 | vs CLE | 160 | W 2-1 | 54-107 | 7 | 0 | Dave Lemanczyk | Jim Bibby | Dave Lemanczyk | Larry Andersen | | 601 | 817 | -216 |
| 1977-10-02 | vs CLE | 161 | L 4-5 | 54-107 | 7 | 27,789 | Jim Clancy | Cardell Camper | Cardell Camper | Jim Clancy | Rick Waits | 605 | 822 | -217 |