| 1977-04-07 | @ BAL | 1 | W 2-1 | 1-0 | 2 | 31,307 | Bert Blyleven | Jim Palmer | Bert Blyleven | Jim Palmer | | 2 | 1 | 1 |
| 1977-04-09 | @ BAL | 2 | W 5-1 | 2-0 | 3 | 5,305 | Gaylord Perry | Rudy May | Gaylord Perry | Rudy May | | 7 | 2 | 5 |
| 1977-04-10 | @ BAL | 3 | W 3-2 | 3-0 | 2 | 5,495 | Doyle Alexander | Ross Grimsley | Doyle Alexander | Ross Grimsley | Paul Lindblad | 10 | 4 | 6 |
| 1977-04-11 | vs CLE | 4 | W 3-2 | 4-0 | 2 | 25,208 | Bert Blyleven | Pat Dobson | Adrian Devine | Dave LaRoche | | 13 | 6 | 7 |
| 1977-04-13 | vs CLE | 5 | L 3-5 | 4-1 | 3 | 12,260 | Tommy Boggs | Dennis Eckersley | Dennis Eckersley | Tommy Boggs | | 16 | 11 | 5 |
| 1977-04-17 | vs BAL | 6 | L 0-5 | 4-3 | 4 | 24,241 | Bert Blyleven | Jim Palmer | Jim Palmer | Bert Blyleven | | 16 | 16 | 0 |
| 1977-04-17 | vs BAL | 7 | L 1-6 | 4-3 | 4 | 24,241 | Gaylord Perry | Ross Grimsley | Ross Grimsley | Gaylord Perry | | 17 | 22 | -5 |
| 1977-04-18 | @ SEA | 8 | L 6-8 | 4-4 | 5 | 9,535 | Doyle Alexander | Stan Thomas | Stan Thomas | Doyle Alexander | Bill Laxton | 23 | 30 | -7 |
| 1977-04-19 | @ SEA | 9 | W 3-1 | 5-4 | 4 | 10,947 | Tommy Boggs | Gary Wheelock | Paul Lindblad | Gary Wheelock | | 26 | 31 | -5 |
| 1977-04-20 | @ SEA | 10 | W 5-2 | 6-4 | 3 | 10,763 | Nelson Briles | John Montague | Nelson Briles | John Montague | Adrian Devine | 31 | 33 | -2 |
| 1977-04-21 | vs MIN | 11 | L 4-11 | 6-5 | 5 | 8,170 | Gaylord Perry | Geoff Zahn | Geoff Zahn | Gaylord Perry | | 35 | 44 | -9 |
| 1977-04-22 | vs MIN | 12 | L 1-4 | 6-6 | 5 | 18,804 | Bert Blyleven | Mike Pazik | Tom Johnson | Bert Blyleven | | 36 | 48 | -12 |
| 1977-04-23 | vs MIN | 13 | W 1-0 | 7-6 | 5 | 14,167 | Doyle Alexander | Dave Goltz | Doyle Alexander | Dave Goltz | | 37 | 48 | -11 |
| 1977-04-24 | vs MIN | 14 | L 6-12 | 7-7 | 5 | 10,544 | Tommy Boggs | Pete Redfern | Pete Redfern | Tommy Boggs | | 43 | 60 | -17 |
| 1977-04-26 | @ KCA | 15 | L 3-6 | 7-8 | 5 | 15,780 | Gaylord Perry | Andy Hassler | Doug Bird | Gaylord Perry | | 46 | 66 | -20 |
| 1977-04-27 | @ KCA | 16 | W 5-0 | 8-8 | 5 | 16,822 | Bert Blyleven | Dennis Leonard | Bert Blyleven | Dennis Leonard | | 51 | 66 | -15 |
| 1977-04-29 | @ CHA | 17 | W 2-1 | 9-8 | 5 | 13,875 | Doyle Alexander | Steve Stone | Doyle Alexander | Steve Stone | | 53 | 67 | -14 |
| 1977-04-30 | @ CHA | 18 | W 14-4 | 10-8 | 5 | 31,635 | Tommy Boggs | Chris Knapp | Nelson Briles | Chris Knapp | | 67 | 71 | -4 |
| 1977-05-01 | @ CHA | 19 | L 4-12 | 10-9 | 5 | 13,964 | Gaylord Perry | Ken Brett | Ken Brett | Gaylord Perry | | 71 | 83 | -12 |
| 1977-05-03 | @ DET | 20 | W 13-0 | 11-9 | 5 | 12,272 | Bert Blyleven | Vern Ruhle | Bert Blyleven | Vern Ruhle | | 84 | 83 | 1 |
| 1977-05-06 | vs KCA | 21 | W 5-2 | 12-9 | 3 | 25,728 | Doyle Alexander | Larry Gura | Doyle Alexander | Larry Gura | | 89 | 85 | 4 |
| 1977-05-07 | vs KCA | 22 | L 5-6 | 12-10 | 4 | 22,166 | Gaylord Perry | Dennis Leonard | Mark Littell | Adrian Devine | | 94 | 91 | 3 |
| 1977-05-08 | vs KCA | 23 | W 5-2 | 13-10 | 3 | 15,581 | Bert Blyleven | Marty Pattin | Bert Blyleven | Marty Pattin | Darold Knowles | 99 | 93 | 6 |
| 1977-05-09 | vs CHA | 24 | L 3-6 | 13-11 | 3 | 6,673 | Tommy Boggs | Ken Brett | Ken Brett | Paul Lindblad | | 102 | 99 | 3 |
| 1977-05-10 | vs CHA | 25 | W 3-2 | 14-11 | 3 | 8,360 | Nelson Briles | Francisco Barrios | Adrian Devine | Dave Hamilton | | 105 | 101 | 4 |
| 1977-05-11 | vs CHA | 26 | L 3-4 | 14-12 | 3 | 8,113 | Doyle Alexander | Chris Knapp | Chris Knapp | Paul Lindblad | | 108 | 105 | 3 |
| 1977-05-12 | @ KCA | 27 | W 2-0 | 15-12 | 3 | 20,391 | Gaylord Perry | Dennis Leonard | Gaylord Perry | Dennis Leonard | | 110 | 105 | 5 |
| 1977-05-13 | @ KCA | 28 | L 2-3 | 15-13 | 3 | 20,872 | Bert Blyleven | Larry Gura | Mark Littell | Bert Blyleven | | 112 | 108 | 4 |
| 1977-05-14 | @ KCA | 29 | L 0-6 | 15-14 | 4 | 29,978 | Tommy Boggs | Jim Colborn | Jim Colborn | Tommy Boggs | | 112 | 114 | -2 |
| 1977-05-15 | @ KCA | 30 | W 7-3 | 16-14 | 3 | 19,983 | Adrian Devine | Paul Splittorff | Adrian Devine | Paul Splittorff | Paul Lindblad | 119 | 117 | 2 |
| 1977-05-17 | vs DET | 31 | W 3-1 | 17-14 | 3 | 10,826 | Doyle Alexander | Dave Rozema | Doyle Alexander | Dave Rozema | | 122 | 118 | 4 |
| 1977-05-18 | vs DET | 32 | W 6-3 | 18-14 | 3 | 10,090 | Gaylord Perry | John Hiller | Gaylord Perry | John Hiller | | 128 | 121 | 7 |
| 1977-05-20 | vs TOR | 33 | L 3-4 | 18-15 | 3 | 21,965 | Bert Blyleven | Jerry Garvin | Jerry Garvin | Bert Blyleven | | 131 | 125 | 6 |
| 1977-05-21 | vs TOR | 34 | L 6-9 | 18-16 | 3 | 20,351 | Nelson Briles | Jesse Jefferson | Jesse Jefferson | Nelson Briles | Mike Willis | 137 | 134 | 3 |
| 1977-05-22 | vs TOR | 35 | W 7-4 | 19-16 | 3 | 21,831 | Doyle Alexander | Dave Lemanczyk | Doyle Alexander | Dave Lemanczyk | Darold Knowles | 144 | 138 | 6 |
| 1977-05-25 | @ NYA | 36 | L 2-3 | 20-17 | 3 | 19,693 | Bert Blyleven | Gil Patterson | Gil Patterson | Bert Blyleven | Sparky Lyle | 146 | 141 | 5 |
| 1977-05-25 | @ NYA | 37 | W 1-0 | 20-17 | 3 | 19,693 | Gaylord Perry | Mike Torrez | Gaylord Perry | Mike Torrez | | 147 | 141 | 6 |
| 1977-05-27 | @ MIL | 38 | L 5-6 | 20-18 | 3 | 12,004 | Doyle Alexander | Jim Slaton | Bill Castro | Paul Lindblad | | 152 | 147 | 5 |
| 1977-05-28 | @ MIL | 39 | L 1-3 | 20-19 | 3 | 19,413 | Nelson Briles | Jerry Augustine | Jerry Augustine | Nelson Briles | | 153 | 150 | 3 |
| 1977-05-29 | @ MIL | 40 | W 5-4 | 21-19 | 3 | 15,281 | Mike Marshall | Bill Travers | Adrian Devine | Sam Hinds | | 158 | 154 | 4 |
| 1977-05-30 | vs SEA | 41 | L 4-7 | 21-21 | 3 | 0 | Bert Blyleven | Dave Pagan | Enrique Romo | Bert Blyleven | Bill Laxton | 162 | 161 | 1 |
| 1977-05-30 | vs SEA | 42 | L 3-9 | 21-21 | 3 | 17,844 | Gaylord Perry | John Montague | John Montague | Gaylord Perry | Diego Segui | 165 | 170 | -5 |
| 1977-06-01 | vs BOS | 43 | L 5-7 | 21-22 | 6 | 11,731 | Doyle Alexander | Luis Tiant | Mike Paxton | Doyle Alexander | Bill Campbell | 170 | 177 | -7 |
| 1977-06-02 | vs BOS | 44 | W 3-1 | 22-22 | 5 | 12,158 | Nelson Briles | Fergie Jenkins | Darold Knowles | Fergie Jenkins | | 173 | 178 | -5 |
| 1977-06-03 | vs MIL | 45 | W 15-8 | 23-22 | 3 | 14,145 | Mike Marshall | Jerry Augustine | Steve Hargan | Jerry Augustine | | 188 | 186 | 2 |
| 1977-06-04 | vs MIL | 46 | L 2-3 | 23-23 | 4 | 15,540 | Bert Blyleven | Moose Haas | Bill Castro | Bert Blyleven | | 190 | 189 | 1 |
| 1977-06-05 | vs MIL | 47 | W 7-6 | 24-23 | 3 | 8,593 | Gaylord Perry | Jim Slaton | Gaylord Perry | Jim Slaton | Adrian Devine | 197 | 195 | 2 |
| 1977-06-06 | vs NYA | 48 | L 2-9 | 24-24 | 3 | 21,978 | Doyle Alexander | Catfish Hunter | Catfish Hunter | Doyle Alexander | | 199 | 204 | -5 |
| 1977-06-07 | vs NYA | 49 | W 7-3 | 25-24 | 3 | 18,075 | Nelson Briles | Ed Figueroa | Paul Lindblad | Ed Figueroa | | 206 | 207 | -1 |
| 1977-06-08 | vs CHA | 50 | W 6-1 | 26-24 | 3 | 10,530 | Bert Blyleven | Ken Kravec | Bert Blyleven | Ken Kravec | | 212 | 208 | 4 |
| 1977-06-09 | vs CHA | 51 | L 3-4 | 26-25 | 3 | 11,920 | Gaylord Perry | Chris Knapp | Larry Anderson | Adrian Devine | | 215 | 212 | 3 |
| 1977-06-12 | @ BOS | 52 | L 2-3 | 26-27 | 4 | 0 | Doyle Alexander | Reggie Cleveland | Reggie Cleveland | Adrian Devine | | 217 | 215 | 2 |
| 1977-06-12 | @ BOS | 53 | L 0-2 | 26-27 | 4 | 31,038 | Nelson Briles | Luis Tiant | Luis Tiant | Nelson Briles | | 217 | 217 | 0 |
| 1977-06-13 | @ CLE | 54 | W 3-0 | 27-27 | 4 | 9,811 | Bert Blyleven | Dennis Eckersley | Bert Blyleven | Dennis Eckersley | | 220 | 217 | 3 |
| 1977-06-14 | @ CLE | 55 | W 7-2 | 28-27 | 4 | 9,248 | Gaylord Perry | Wayne Garland | Gaylord Perry | Wayne Garland | | 227 | 219 | 8 |
| 1977-06-15 | @ CLE | 56 | W 6-0 | 29-27 | 3 | 5,883 | Mike Marshall | Jim Bibby | Mike Marshall | Jim Bibby | | 233 | 219 | 14 |
| 1977-06-17 | vs SEA | 57 | L 1-2 | 30-28 | 3 | 0 | Doyle Alexander | Dick Pole | Dick Pole | Mike Marshall | Tom House | 234 | 221 | 13 |
| 1977-06-17 | vs SEA | 58 | W 8-6 | 30-28 | 3 | 21,577 | Nelson Briles | Gary Wheelock | Nelson Briles | Gary Wheelock | Adrian Devine | 242 | 227 | 15 |
| 1977-06-18 | vs SEA | 59 | L 1-6 | 30-29 | 3 | 17,352 | Bert Blyleven | Rick Jones | Rick Jones | Bert Blyleven | | 243 | 233 | 10 |
| 1977-06-19 | vs SEA | 60 | L 1-2 | 30-30 | 5 | 12,465 | Gaylord Perry | Diego Segui | Enrique Romo | Gaylord Perry | | 244 | 235 | 9 |
| 1977-06-20 | @ MIN | 61 | W 2-1 | 31-30 | 3 | 6,966 | Dock Ellis | Paul Thormodsgard | Dock Ellis | Paul Thormodsgard | Paul Lindblad | 246 | 236 | 10 |
| 1977-06-21 | @ MIN | 62 | L 5-9 | 31-31 | 4 | 8,792 | Doyle Alexander | Geoff Zahn | Ron Schueler | Doyle Alexander | Tom Johnson | 251 | 245 | 6 |
| 1977-06-22 | @ MIN | 63 | W 10-8 | 32-31 | 3 | 10,687 | Bert Blyleven | Bill Butler | Darold Knowles | Tom Burgmeier | Mike Marshall | 261 | 253 | 8 |
| 1977-06-23 | @ MIN | 64 | L 2-12 | 32-32 | 4 | 18,060 | Nelson Briles | Dave Goltz | Dave Goltz | Nelson Briles | | 263 | 265 | -2 |
| 1977-06-24 | @ CAL | 65 | W 1-0 | 33-32 | 3 | 18,983 | Gaylord Perry | Frank Tanana | Adrian Devine | Frank Tanana | | 264 | 265 | -1 |
| 1977-06-25 | @ CAL | 66 | L 2-3 | 33-33 | 4 | 15,247 | Dock Ellis | Nolan Ryan | Dave LaRoche | Mike Marshall | | 266 | 268 | -2 |
| 1977-06-26 | @ CAL | 67 | L 3-4 | 33-35 | 5 | 0 | Doyle Alexander | Gary Ross | Paul Hartzell | Doyle Alexander | | 269 | 272 | -3 |
| 1977-06-26 | @ CAL | 68 | L 3-4 | 33-35 | 5 | 37,768 | Nelson Briles | Ken Brett | Paul Hartzell | Adrian Devine | Dave LaRoche | 272 | 276 | -4 |
| 1977-06-27 | @ OAK | 69 | W 5-2 | 34-35 | 5 | 13,024 | Mike Marshall | Paul Mitchell | Mike Marshall | Paul Mitchell | Paul Lindblad | 277 | 278 | -1 |
| 1977-06-28 | @ OAK | 70 | L 5-6 | 34-36 | 5 | 5,761 | Roger Moret | Doc Medich | Dave Giusti | Adrian Devine | | 282 | 284 | -2 |
| 1977-06-29 | @ OAK | 71 | W 4-0 | 35-37 | 5 | 0 | Gaylord Perry | Mike Norris | Gaylord Perry | Mike Norris | | 286 | 284 | 2 |
| 1977-06-29 | @ OAK | 72 | L 1-4 | 35-37 | 5 | 17,370 | Dock Ellis | Rick Langford | Rick Langford | Dock Ellis | | 287 | 288 | -1 |
| 1977-07-01 | @ TOR | 73 | W 11-8 | 36-37 | 5 | 21,089 | Doyle Alexander | Jeff Byrd | Doyle Alexander | Jeff Byrd | Adrian Devine | 298 | 296 | 2 |
| 1977-07-02 | @ TOR | 74 | L 7-10 | 36-38 | 5 | 19,176 | Len Barker | Pete Vuckovich | Pete Vuckovich | Len Barker | | 305 | 306 | -1 |
| 1977-07-03 | @ TOR | 75 | W 6-3 | 37-39 | 5 | 0 | Dock Ellis | Dave Lemanczyk | Dock Ellis | Mike Willis | Darold Knowles | 311 | 309 | 2 |
| 1977-07-03 | @ TOR | 76 | L 3-5 | 37-39 | 5 | 32,066 | Roger Moret | Jesse Jefferson | Jesse Jefferson | Darold Knowles | | 314 | 314 | 0 |
| 1977-07-04 | vs KCA | 77 | L 0-1 | 37-40 | 5 | 34,660 | Gaylord Perry | Jim Colborn | Jim Colborn | Gaylord Perry | Mark Littell | 314 | 315 | -1 |
| 1977-07-05 | vs KCA | 78 | L 4-6 | 37-41 | 5 | 11,036 | Bert Blyleven | Doug Bird | Larry Gura | Bert Blyleven | Mark Littell | 318 | 321 | -3 |
| 1977-07-06 | vs OAK | 79 | W 4-3 | 38-41 | 5 | 7,729 | Doyle Alexander | Doc Medich | Doyle Alexander | Bob Lacey | Adrian Devine | 322 | 324 | -2 |
| 1977-07-07 | vs OAK | 80 | W 8-3 | 39-41 | 5 | 11,346 | Len Barker | Mike Norris | Roger Moret | Mike Norris | | 330 | 327 | 3 |
| 1977-07-08 | vs CAL | 81 | W 9-5 | 40-41 | 4 | 34,238 | Dock Ellis | Nolan Ryan | Dock Ellis | Nolan Ryan | Darold Knowles | 339 | 332 | 7 |
| 1977-07-09 | vs CAL | 82 | W 7-2 | 41-41 | 4 | 17,550 | Gaylord Perry | Wayne Simpson | Gaylord Perry | Wayne Simpson | | 346 | 334 | 12 |
| 1977-07-10 | vs CAL | 83 | W 4-2 | 42-41 | 4 | 14,321 | Bert Blyleven | Ken Brett | Bert Blyleven | Ken Brett | Adrian Devine | 350 | 336 | 14 |
| 1977-07-12 | vs BAL | 84 | W 4-3 | 43-41 | 4 | 8,646 | Doyle Alexander | Rudy May | Doyle Alexander | Dick Drago | | 354 | 339 | 15 |
| 1977-07-13 | vs BAL | 85 | L 3-4 | 43-42 | 4 | 16,805 | Dock Ellis | Jim Palmer | Jim Palmer | Dock Ellis | Tippy Martinez | 357 | 343 | 14 |
| 1977-07-14 | vs BAL | 86 | L 1-6 | 43-43 | 4 | 14,205 | Gaylord Perry | Ross Grimsley | Ross Grimsley | Gaylord Perry | | 358 | 349 | 9 |
| 1977-07-15 | vs CLE | 87 | W 8-3 | 45-43 | 4 | 0 | Bert Blyleven | Jim Bibby | Bert Blyleven | Jim Bibby | | 366 | 352 | 14 |
| 1977-07-15 | vs CLE | 88 | W 8-1 | 45-43 | 4 | 15,946 | Len Barker | Pat Dobson | Len Barker | Pat Dobson | Nelson Briles | 374 | 353 | 21 |
| 1977-07-16 | vs CLE | 89 | W 5-4 | 46-43 | 4 | 19,884 | Doyle Alexander | Dennis Eckersley | Doyle Alexander | Jim Kern | Adrian Devine | 379 | 357 | 22 |
| 1977-07-17 | vs CLE | 90 | L 1-6 | 46-44 | 4 | 13,192 | Dock Ellis | Wayne Garland | Wayne Garland | Dock Ellis | | 380 | 363 | 17 |
| 1977-07-22 | @ BAL | 91 | W 5-1 | 47-44 | 4 | 39,323 | Bert Blyleven | Ross Grimsley | Bert Blyleven | Ross Grimsley | | 385 | 364 | 21 |
| 1977-07-23 | @ BAL | 92 | W 1-0 | 48-44 | 4 | 10,738 | Gaylord Perry | Jim Palmer | Adrian Devine | Dick Drago | | 386 | 364 | 22 |
| 1977-07-24 | @ CLE | 93 | W 4-1 | 49-44 | 4 | 14,177 | Doyle Alexander | Wayne Garland | Doyle Alexander | Wayne Garland | | 390 | 365 | 25 |
| 1977-07-25 | @ CLE | 94 | W 6-4 | 50-44 | 4 | 10,752 | Dock Ellis | Jim Bibby | Nelson Briles | Jim Kern | Adrian Devine | 396 | 369 | 27 |
| 1977-07-26 | @ TOR | 95 | W 14-0 | 51-44 | 4 | 22,357 | Bert Blyleven | Jim Clancy | Bert Blyleven | Jim Clancy | | 410 | 369 | 41 |
| 1977-07-28 | @ TOR | 96 | W 3-0 | 52-44 | 4 | 17,512 | Gaylord Perry | Jerry Garvin | Gaylord Perry | Jerry Garvin | | 413 | 369 | 44 |
| 1977-07-29 | vs DET | 97 | L 6-13 | 52-45 | 4 | 20,034 | Doyle Alexander | Dave Rozema | Dave Rozema | Doyle Alexander | | 419 | 382 | 37 |
| 1977-07-30 | vs DET | 98 | W 6-5 | 53-45 | 4 | 22,369 | Dock Ellis | Bob Sykes | Paul Lindblad | John Hiller | | 425 | 387 | 38 |
| 1977-07-31 | vs DET | 99 | W 3-2 | 54-45 | 4 | 16,309 | Bert Blyleven | Jack Morris | Adrian Devine | Jim Crawford | | 428 | 389 | 39 |
| 1977-08-01 | @ CHA | 100 | W 11-6 | 55-45 | 4 | 31,234 | Gaylord Perry | Wilbur Wood | Gaylord Perry | Wilbur Wood | Adrian Devine | 439 | 395 | 44 |
| 1977-08-02 | @ CHA | 101 | W 9-8 | 56-45 | 4 | 19,014 | Doyle Alexander | Ken Kravec | Darold Knowles | Bart Johnson | | 448 | 403 | 45 |
| 1977-08-03 | @ CHA | 102 | W 12-10 | 57-45 | 4 | 22,672 | Dock Ellis | Francisco Barrios | Adrian Devine | Don Kirkwood | | 460 | 413 | 47 |
| 1977-08-04 | @ CHA | 103 | L 4-5 | 57-46 | 4 | 20,155 | Bert Blyleven | Steve Stone | Steve Stone | Bert Blyleven | Lerrin LaGrow | 464 | 418 | 46 |
| 1977-08-05 | @ DET | 104 | W 4-3 | 59-46 | 4 | 0 | Gaylord Perry | Jack Morris | Darold Knowles | John Hiller | | 468 | 421 | 47 |
| 1977-08-05 | @ DET | 105 | W 6-0 | 59-46 | 4 | 27,094 | Nelson Briles | Bob Sykes | Nelson Briles | Bob Sykes | | 474 | 421 | 53 |
| 1977-08-06 | @ DET | 106 | L 5-6 | 59-47 | 4 | 24,771 | Doyle Alexander | Milt Wilcox | Milt Wilcox | Doyle Alexander | Steve Foucault | 479 | 427 | 52 |
| 1977-08-07 | @ DET | 107 | W 4-1 | 60-47 | 4 | 17,597 | Dock Ellis | Fernando Arroyo | Dock Ellis | Fernando Arroyo | | 483 | 428 | 55 |
| 1977-08-08 | vs OAK | 108 | W 5-2 | 62-47 | 3 | 0 | Bert Blyleven | Jim Umbarger | Bert Blyleven | Jim Umbarger | | 488 | 430 | 58 |
| 1977-08-08 | vs OAK | 109 | W 3-0 | 62-47 | 3 | 19,909 | Roger Moret | Doc Medich | Roger Moret | Doc Medich | Adrian Devine | 491 | 430 | 61 |
| 1977-08-10 | vs KCA | 110 | L 3-4 | 62-48 | 4 | 26,349 | Gaylord Perry | Dennis Leonard | Dennis Leonard | Gaylord Perry | Larry Gura | 494 | 434 | 60 |
| 1977-08-11 | vs KCA | 111 | W 8-3 | 63-48 | 3 | 21,770 | Doyle Alexander | Jim Colborn | Doyle Alexander | Jim Colborn | Roger Moret | 502 | 437 | 65 |
| 1977-08-12 | vs CHA | 112 | W 10-7 | 64-48 | 3 | 36,852 | Dock Ellis | Francisco Barrios | Darold Knowles | Lerrin LaGrow | | 512 | 444 | 68 |
| 1977-08-13 | vs CHA | 113 | L 5-6 | 64-49 | 4 | 35,132 | Bert Blyleven | Steve Stone | Steve Stone | Bert Blyleven | Dave Hamilton | 517 | 450 | 67 |
| 1977-08-14 | vs CHA | 114 | W 12-9 | 65-49 | 3 | 29,734 | Nelson Briles | Jack Kucek | Paul Lindblad | Bart Johnson | Dock Ellis | 529 | 459 | 70 |
| 1977-08-15 | @ MIL | 115 | L 5-6 | 65-50 | 3 | 6,812 | Gaylord Perry | Jerry Augustine | Eduardo Rodriguez | Adrian Devine | | 534 | 465 | 69 |
| 1977-08-16 | @ MIL | 116 | W 11-3 | 66-50 | 3 | 7,777 | Doyle Alexander | Moose Haas | Doyle Alexander | Moose Haas | | 545 | 468 | 77 |
| 1977-08-17 | vs TOR | 117 | W 6-5 | 67-50 | 1 | 12,913 | Nelson Briles | Dave Lemanczyk | Adrian Devine | Mike Willis | | 551 | 473 | 78 |
| 1977-08-18 | vs TOR | 118 | W 8-0 | 68-50 | 1 | 15,740 | Dock Ellis | Jim Clancy | Dock Ellis | Jim Clancy | | 559 | 473 | 86 |
| 1977-08-19 | vs NYA | 119 | L 1-8 | 68-51 | 2 | 31,159 | Roger Moret | Mike Torrez | Mike Torrez | Roger Moret | | 560 | 481 | 79 |
| 1977-08-20 | vs NYA | 120 | L 2-6 | 68-52 | 3 | 34,004 | Gaylord Perry | Dick Tidrow | Dick Tidrow | Gaylord Perry | Sparky Lyle | 562 | 487 | 75 |
| 1977-08-21 | vs NYA | 121 | L 1-2 | 68-53 | 4 | 27,004 | Doyle Alexander | Ron Guidry | Ron Guidry | Doyle Alexander | Sparky Lyle | 563 | 489 | 74 |
| 1977-08-22 | vs MIL | 122 | W 8-7 | 69-53 | 4 | 7,854 | Bert Blyleven | Lary Sorensen | Adrian Devine | Eduardo Rodriguez | | 571 | 496 | 75 |
| 1977-08-23 | vs MIL | 123 | L 2-4 | 69-54 | 4 | 12,339 | Dock Ellis | Mike Caldwell | Mike Caldwell | Dock Ellis | Bill Castro | 573 | 500 | 73 |
| 1977-08-24 | @ BOS | 124 | W 3-0 | 71-54 | 2 | 0 | Gaylord Perry | Mike Paxton | Gaylord Perry | Mike Paxton | Adrian Devine | 576 | 500 | 76 |
| 1977-08-24 | @ BOS | 125 | W 6-3 | 71-54 | 2 | 31,784 | Nelson Briles | Reggie Cleveland | Len Barker | Reggie Cleveland | | 582 | 503 | 79 |
| 1977-08-25 | @ BOS | 126 | L 6-9 | 71-55 | 3 | 30,186 | Doyle Alexander | Luis Tiant | Jim Willoughby | Darold Knowles | Bill Campbell | 588 | 512 | 76 |
| 1977-08-26 | @ NYA | 127 | L 5-6 | 71-56 | 4 | 29,000 | Roger Moret | Ed Figueroa | Ken Clay | Roger Moret | Sparky Lyle | 593 | 518 | 75 |
| 1977-08-27 | @ NYA | 128 | W 8-2 | 72-56 | 3 | 33,179 | Bert Blyleven | Mike Torrez | Bert Blyleven | Mike Torrez | | 601 | 520 | 81 |
| 1977-08-28 | @ NYA | 129 | L 0-1 | 72-57 | 3 | 37,714 | Dock Ellis | Ron Guidry | Ron Guidry | Dock Ellis | | 601 | 521 | 80 |
| 1977-08-30 | @ KCA | 130 | W 8-2 | 73-57 | 4 | 27,154 | Gaylord Perry | Dennis Leonard | Gaylord Perry | Dennis Leonard | | 609 | 523 | 86 |
| 1977-08-31 | @ KCA | 131 | L 4-5 | 73-58 | 4 | 25,223 | Doyle Alexander | Jim Colborn | Jim Colborn | Doyle Alexander | Doug Bird | 613 | 528 | 85 |
| 1977-09-02 | vs BOS | 132 | W 6-4 | 74-58 | 3 | 18,883 | Bert Blyleven | Fergie Jenkins | Bert Blyleven | Fergie Jenkins | Roger Moret | 619 | 532 | 87 |
| 1977-09-03 | vs BOS | 133 | L 1-2 | 74-59 | 3 | 36,852 | Dock Ellis | Mike Paxton | Mike Paxton | Dock Ellis | Bill Campbell | 620 | 534 | 86 |
| 1977-09-04 | vs BOS | 134 | L 4-8 | 74-60 | 3 | 27,794 | Gaylord Perry | Luis Tiant | Rick Wise | Gaylord Perry | Bill Campbell | 624 | 542 | 82 |
| 1977-09-05 | @ MIN | 135 | L 4-5 | 74-61 | 4 | 9,067 | Doyle Alexander | Paul Thormodsgard | Paul Thormodsgard | Doyle Alexander | Tom Burgmeier | 628 | 547 | 81 |
| 1977-09-06 | @ MIN | 136 | L 4-7 | 74-62 | 4 | 6,444 | Bert Blyleven | Dave Goltz | Dave Goltz | Bert Blyleven | | 632 | 554 | 78 |
| 1977-09-07 | @ MIN | 137 | W 4-3 | 75-62 | 4 | 6,811 | Dock Ellis | Ron Schueler | Dock Ellis | Tom Johnson | Roger Moret | 636 | 557 | 79 |
| 1977-09-09 | @ SEA | 138 | L 3-8 | 75-63 | 4 | 8,245 | Gaylord Perry | Tom House | Tom House | Gaylord Perry | | 639 | 565 | 74 |
| 1977-09-10 | @ SEA | 139 | W 5-2 | 77-63 | 3 | 0 | Doyle Alexander | Paul Mitchell | Doyle Alexander | Paul Mitchell | | 644 | 567 | 77 |
| 1977-09-10 | @ SEA | 140 | W 7-1 | 77-63 | 3 | 12,800 | Roger Moret | Mike Kekich | Roger Moret | Mike Kekich | | 651 | 568 | 83 |
| 1977-09-11 | @ SEA | 141 | L 4-6 | 77-64 | 3 | 8,363 | Adrian Devine | Rick Honeycutt | Enrique Romo | Paul Lindblad | | 655 | 574 | 81 |
| 1977-09-12 | vs CAL | 142 | W 3-2 | 78-64 | 3 | 5,258 | Dock Ellis | Nolan Ryan | Dock Ellis | Nolan Ryan | Len Barker | 658 | 576 | 82 |
| 1977-09-13 | vs CAL | 143 | L 7-12 | 78-65 | 3 | 5,922 | Gaylord Perry | Balor Moore | Mike Barlow | Jim Umbarger | | 665 | 588 | 77 |
| 1977-09-14 | vs CAL | 144 | W 2-1 | 79-65 | 3 | 4,538 | Doyle Alexander | Ken Brett | Doyle Alexander | Ken Brett | | 667 | 589 | 78 |
| 1977-09-15 | vs CAL | 145 | W 6-4 | 80-65 | 3 | 5,497 | Nelson Briles | John Caneira | Nelson Briles | John Caneira | Adrian Devine | 673 | 593 | 80 |
| 1977-09-16 | vs MIN | 146 | L 7-9 | 80-66 | 3 | 20,632 | Roger Moret | Pete Redfern | Tom Johnson | Roger Moret | | 680 | 602 | 78 |
| 1977-09-17 | vs MIN | 147 | W 5-4 | 81-66 | 2 | 13,163 | Dock Ellis | Dave Johnson | Len Barker | Don Carrithers | | 685 | 606 | 79 |
| 1977-09-18 | vs MIN | 148 | W 5-4 | 83-66 | 2 | 0 | Gaylord Perry | Paul Thormodsgard | Gaylord Perry | Paul Thormodsgard | Adrian Devine | 690 | 610 | 80 |
| 1977-09-18 | vs MIN | 149 | W 10-8 | 83-66 | 2 | 10,575 | Jim Umbarger | Dave Goltz | Jim Umbarger | Dave Goltz | Adrian Devine | 700 | 618 | 82 |
| 1977-09-19 | @ CAL | 150 | W 6-1 | 84-66 | 2 | 26,718 | Doyle Alexander | Nolan Ryan | Doyle Alexander | Nolan Ryan | | 706 | 619 | 87 |
| 1977-09-20 | @ CAL | 151 | L 2-5 | 84-67 | 3 | 9,415 | Paul Lindblad | Ken Brett | Ken Brett | Paul Lindblad | | 708 | 624 | 84 |
| 1977-09-21 | @ CAL | 152 | W 9-1 | 85-67 | 2 | 8,426 | Dock Ellis | John Caneira | Dock Ellis | John Caneira | | 717 | 625 | 92 |
| 1977-09-22 | @ CAL | 153 | W 6-0 | 86-67 | 2 | 8,031 | Bert Blyleven | Paul Hartzell | Bert Blyleven | Paul Hartzell | | 723 | 625 | 98 |
| 1977-09-23 | @ OAK | 154 | W 6-5 | 87-67 | 2 | 1,798 | Gaylord Perry | Matt Keough | Gaylord Perry | Doug Bair | | 729 | 630 | 99 |
| 1977-09-24 | @ OAK | 155 | W 3-1 | 88-67 | 2 | 2,036 | Doyle Alexander | Vida Blue | Doyle Alexander | Vida Blue | | 732 | 631 | 101 |
| 1977-09-25 | @ OAK | 156 | W 5-4 | 90-67 | 2 | 0 | Roger Moret | Pablo Torrealba | Len Barker | Bob Lacey | | 737 | 635 | 102 |
| 1977-09-25 | @ OAK | 157 | W 8-6 | 90-67 | 2 | 2,479 | Dock Ellis | Rick Langford | Dock Ellis | Rick Langford | Adrian Devine | 745 | 641 | 104 |
| 1977-09-28 | vs SEA | 158 | W 3-1 | 91-67 | 2 | 4,860 | Gaylord Perry | Glenn Abbott | Gaylord Perry | Glenn Abbott | | 748 | 642 | 106 |
| 1977-09-29 | vs SEA | 159 | L 1-2 | 91-68 | 2 | 4,714 | Doyle Alexander | Paul Mitchell | Paul Mitchell | Doyle Alexander | Enrique Romo | 749 | 644 | 105 |
| 1977-09-30 | vs OAK | 160 | W 4-1 | 92-68 | 2 | 7,471 | Dock Ellis | Pablo Torrealba | Dock Ellis | Pablo Torrealba | | 753 | 645 | 108 |
| 1977-10-01 | vs OAK | 161 | W 6-5 | 93-68 | 2 | 10,768 | Jim Umbarger | Steve McCatty | Adrian Devine | Doug Bair | | 759 | 650 | 109 |
| 1977-10-02 | vs OAK | 162 | W 8-7 | 94-68 | 2 | 5,779 | John Poloni | Matt Keough | John Poloni | Matt Keough | Roger Moret | 767 | 657 | 110 |