| 1977-04-06 | vs CAL | 1 | L 0-7 | 0-1 | 6 | 57,762 | Diego Segui | Frank Tanana | Frank Tanana | Diego Segui | | 0 | 7 | -7 |
| 1977-04-07 | vs CAL | 2 | L 0-2 | 0-2 | 7 | 10,144 | Enrique Romo | Nolan Ryan | Nolan Ryan | Enrique Romo | | 0 | 9 | -9 |
| 1977-04-08 | vs CAL | 3 | W 7-6 | 1-2 | 4 | 11,845 | Stan Thomas | Gary Ross | Bill Laxton | John Verhoeven | | 7 | 15 | -8 |
| 1977-04-09 | vs CAL | 4 | W 5-1 | 2-2 | 5 | 27,668 | Gary Wheelock | Wayne Simpson | Gary Wheelock | Wayne Simpson | John Montague | 12 | 16 | -4 |
| 1977-04-10 | vs CAL | 5 | L 5-12 | 2-3 | 5 | 10,405 | Glenn Abbott | Frank Tanana | Frank Tanana | Glenn Abbott | | 17 | 28 | -11 |
| 1977-04-11 | vs MIN | 6 | L 3-12 | 2-4 | 7 | 8,979 | Diego Segui | Geoff Zahn | Geoff Zahn | Diego Segui | | 20 | 40 | -20 |
| 1977-04-12 | vs MIN | 7 | L 2-3 | 2-5 | 7 | 8,589 | Enrique Romo | Mike Pazik | Ron Schueler | Bill Laxton | Tom Burgmeier | 22 | 43 | -21 |
| 1977-04-13 | vs MIN | 8 | W 3-2 | 3-5 | 6 | 11,635 | Stan Thomas | Dave Goltz | Tommy Moore | Tom Burgmeier | | 25 | 45 | -20 |
| 1977-04-14 | vs MIN | 9 | W 4-3 | 4-5 | 5 | 9,167 | Gary Wheelock | Pete Redfern | Gary Wheelock | Pete Redfern | John Montague | 29 | 48 | -19 |
| 1977-04-15 | @ CAL | 10 | L 0-7 | 4-6 | 5 | 34,654 | Glenn Abbott | Nolan Ryan | Nolan Ryan | Glenn Abbott | | 29 | 55 | -26 |
| 1977-04-16 | @ CAL | 11 | L 4-6 | 4-7 | 7 | 19,690 | Diego Segui | Paul Hartzell | Paul Hartzell | John Montague | Don Kirkwood | 33 | 61 | -28 |
| 1977-04-17 | @ CAL | 12 | W 11-7 | 5-7 | 6 | 13,813 | Enrique Romo | Wayne Simpson | Mike Kekich | Sid Monge | Dave Pagan | 44 | 68 | -24 |
| 1977-04-18 | vs TEX | 13 | W 8-6 | 6-7 | 6 | 9,535 | Stan Thomas | Doyle Alexander | Stan Thomas | Doyle Alexander | Bill Laxton | 52 | 74 | -22 |
| 1977-04-19 | vs TEX | 14 | L 1-3 | 6-8 | 7 | 10,947 | Gary Wheelock | Tommy Boggs | Paul Lindblad | Gary Wheelock | | 53 | 77 | -24 |
| 1977-04-20 | vs TEX | 15 | L 2-5 | 6-9 | 7 | 10,763 | John Montague | Nelson Briles | Nelson Briles | John Montague | Adrian Devine | 55 | 82 | -27 |
| 1977-04-22 | vs KCA | 16 | L 5-6 | 6-10 | 7 | 19,756 | Glenn Abbott | Andy Hassler | Mark Littell | Dave Pagan | Larry Gura | 60 | 88 | -28 |
| 1977-04-23 | vs KCA | 17 | L 6-8 | 6-11 | 7 | 22,685 | Stan Thomas | Dennis Leonard | Dennis Leonard | Diego Segui | Larry Gura | 66 | 96 | -30 |
| 1977-04-24 | vs KCA | 18 | L 1-16 | 7-12 | 7 | 0 | Gary Wheelock | Jim Colborn | Jim Colborn | Gary Wheelock | | 67 | 112 | -45 |
| 1977-04-24 | vs KCA | 19 | W 4-2 | 7-12 | 7 | 21,734 | Frank MacCormack | Paul Splittorff | John Montague | Paul Splittorff | | 71 | 114 | -43 |
| 1977-04-26 | @ MIN | 20 | L 3-5 | 7-13 | 7 | 3,422 | Glenn Abbott | Geoff Zahn | Tom Burgmeier | Stan Thomas | Tom Johnson | 74 | 119 | -45 |
| 1977-04-27 | @ MIN | 21 | L 3-5 | 7-14 | 7 | 3,170 | Tommy Moore | Paul Thormodsgard | Tom Johnson | Tommy Moore | Tom Burgmeier | 77 | 124 | -47 |
| 1977-04-28 | @ MIN | 22 | W 4-3 | 8-14 | 7 | 3,766 | Frank MacCormack | Dave Goltz | John Montague | Dave Goltz | | 81 | 127 | -46 |
| 1977-04-29 | @ NYA | 23 | L 0-3 | 8-15 | 7 | 15,284 | Stan Thomas | Ron Guidry | Ron Guidry | Stan Thomas | Sparky Lyle | 81 | 130 | -49 |
| 1977-04-30 | @ NYA | 24 | L 2-7 | 8-16 | 7 | 19,525 | Gary Wheelock | Ed Figueroa | Ed Figueroa | Gary Wheelock | | 83 | 137 | -54 |
| 1977-05-01 | @ NYA | 25 | L 2-5 | 8-17 | 7 | 20,477 | Glenn Abbott | Ken Holtzman | Ken Holtzman | Glenn Abbott | Sparky Lyle | 85 | 142 | -57 |
| 1977-05-03 | @ BOS | 26 | W 10-8 | 9-17 | 7 | 12,422 | Frank MacCormack | Rick Wise | John Montague | Rick Wise | Dave Pagan | 95 | 150 | -55 |
| 1977-05-04 | @ BOS | 27 | L 2-5 | 9-18 | 7 | 11,408 | Stan Thomas | Reggie Cleveland | Reggie Cleveland | Stan Thomas | Bill Campbell | 97 | 155 | -58 |
| 1977-05-05 | @ BOS | 28 | L 2-5 | 9-19 | 7 | 10,358 | Diego Segui | Fergie Jenkins | Fergie Jenkins | Diego Segui | | 99 | 160 | -61 |
| 1977-05-06 | @ BAL | 29 | L 1-4 | 9-20 | 7 | 4,402 | Glenn Abbott | Ross Grimsley | Ross Grimsley | Glenn Abbott | | 100 | 164 | -64 |
| 1977-05-07 | @ BAL | 30 | L 2-4 | 9-21 | 7 | 16,212 | Rick Jones | Rudy May | Rudy May | Rick Jones | Mike Flanagan | 102 | 168 | -66 |
| 1977-05-08 | @ BAL | 31 | L 4-6 | 9-22 | 7 | 9,638 | Dick Pole | Jim Palmer | Jim Palmer | Dick Pole | Scott McGregor | 106 | 174 | -68 |
| 1977-05-09 | @ TOR | 32 | L 4-10 | 9-23 | 7 | 11,680 | Stan Thomas | Bill Singer | Bill Singer | Stan Thomas | | 110 | 184 | -74 |
| 1977-05-10 | @ TOR | 33 | L 3-9 | 9-24 | 7 | 13,017 | John Montague | Jerry Garvin | Jerry Garvin | John Montague | | 113 | 193 | -80 |
| 1977-05-11 | vs NYA | 34 | W 5-2 | 10-24 | 7 | 23,978 | Glenn Abbott | Ken Holtzman | Bill Laxton | Ken Holtzman | Enrique Romo | 118 | 195 | -77 |
| 1977-05-12 | vs NYA | 35 | W 8-6 | 11-24 | 7 | 42,132 | Rick Jones | Catfish Hunter | Tommy Moore | Catfish Hunter | | 126 | 201 | -75 |
| 1977-05-13 | vs BOS | 36 | L 5-7 | 11-25 | 7 | 20,523 | Dick Pole | Luis Tiant | Jim Willoughby | Enrique Romo | Bill Campbell | 131 | 208 | -77 |
| 1977-05-14 | vs BOS | 37 | L 4-8 | 11-26 | 7 | 52,485 | Stan Thomas | Bob Stanley | Bob Stanley | Stan Thomas | Bill Campbell | 135 | 216 | -81 |
| 1977-05-15 | vs BOS | 38 | L 4-5 | 11-27 | 7 | 47,353 | Rick Jones | Bill Lee | Bill Lee | Rick Jones | Bill Campbell | 139 | 221 | -82 |
| 1977-05-16 | vs BAL | 39 | W 8-3 | 12-27 | 7 | 10,388 | Glenn Abbott | Jim Palmer | Glenn Abbott | Jim Palmer | Mike Kekich | 147 | 224 | -77 |
| 1977-05-17 | vs BAL | 40 | W 10-2 | 13-27 | 7 | 10,920 | Dick Pole | Rudy May | Enrique Romo | Rudy May | | 157 | 226 | -69 |
| 1977-05-19 | @ OAK | 41 | W 3-0 | 14-27 | 7 | 2,179 | Dave Pagan | Rick Langford | Dave Pagan | Rick Langford | | 160 | 226 | -66 |
| 1977-05-20 | @ OAK | 42 | L 5-14 | 14-28 | 7 | 2,660 | Rick Jones | Doc Medich | Doc Medich | Rick Jones | | 165 | 240 | -75 |
| 1977-05-21 | @ OAK | 43 | W 7-6 | 15-28 | 7 | 3,230 | Glenn Abbott | Dock Ellis | Mike Kekich | Bob Lacey | | 172 | 246 | -74 |
| 1977-05-22 | @ OAK | 44 | W 6-2 | 16-28 | 7 | 3,138 | Dick Pole | Vida Blue | Dick Pole | Vida Blue | Enrique Romo | 178 | 248 | -70 |
| 1977-05-24 | @ CLE | 45 | L 5-7 | 16-29 | 7 | 5,576 | Dave Pagan | Pat Dobson | Rick Waits | Enrique Romo | Jim Kern | 183 | 255 | -72 |
| 1977-05-25 | @ CLE | 46 | L 1-2 | 16-30 | 7 | 4,516 | John Montague | Dennis Eckersley | Dennis Eckersley | Bill Laxton | | 184 | 257 | -73 |
| 1977-05-27 | @ DET | 47 | W 2-1 | 17-30 | 7 | 44,207 | Glenn Abbott | Mark Fidrych | Glenn Abbott | Mark Fidrych | Mike Kekich | 186 | 258 | -72 |
| 1977-05-28 | @ DET | 48 | W 3-1 | 18-30 | 7 | 15,820 | Dick Pole | Dave Rozema | Dick Pole | Dave Rozema | Bill Laxton | 189 | 259 | -70 |
| 1977-05-29 | @ DET | 49 | W 6-4 | 19-30 | 7 | 11,778 | Rick Jones | Fernando Arroyo | Stan Thomas | Steve Foucault | | 195 | 263 | -68 |
| 1977-05-30 | @ TEX | 50 | W 7-4 | 21-30 | 7 | 0 | Dave Pagan | Bert Blyleven | Enrique Romo | Bert Blyleven | Bill Laxton | 202 | 267 | -65 |
| 1977-05-30 | @ TEX | 51 | W 9-3 | 21-30 | 7 | 17,844 | John Montague | Gaylord Perry | John Montague | Gaylord Perry | Diego Segui | 211 | 270 | -59 |
| 1977-06-01 | vs OAK | 52 | L 3-6 | 21-31 | 7 | 14,350 | Glenn Abbott | Doc Medich | Doc Medich | Glenn Abbott | Joe Coleman | 214 | 276 | -62 |
| 1977-06-02 | vs OAK | 53 | L 0-1 | 21-32 | 7 | 10,712 | Dick Pole | Mike Norris | Mike Norris | Dick Pole | | 214 | 277 | -63 |
| 1977-06-03 | vs CLE | 54 | L 1-7 | 21-33 | 7 | 19,438 | Rick Jones | Dennis Eckersley | Dennis Eckersley | Rick Jones | Jim Kern | 215 | 284 | -69 |
| 1977-06-04 | vs CLE | 55 | L 5-7 | 21-34 | 7 | 24,074 | Dave Pagan | Wayne Garland | Rick Waits | Mike Kekich | Sid Monge | 220 | 291 | -71 |
| 1977-06-05 | vs CLE | 56 | W 6-1 | 22-34 | 7 | 14,167 | John Montague | Jim Bibby | John Montague | Jim Bibby | | 226 | 292 | -66 |
| 1977-06-07 | vs DET | 57 | L 2-5 | 22-35 | 7 | 10,050 | Glenn Abbott | Dave Rozema | Dave Rozema | Glenn Abbott | Steve Foucault | 228 | 297 | -69 |
| 1977-06-08 | vs DET | 58 | W 3-2 | 23-35 | 7 | 11,211 | Dick Pole | John Hiller | Mike Kekich | John Hiller | | 231 | 299 | -68 |
| 1977-06-09 | vs DET | 59 | W 2-1 | 24-35 | 7 | 10,840 | Rick Jones | Dave Roberts | Enrique Romo | Bob Sykes | | 233 | 300 | -67 |
| 1977-06-10 | vs TOR | 60 | L 3-4 | 24-36 | 7 | 11,786 | John Montague | Dave Lemanczyk | Dave Lemanczyk | John Montague | Mike Willis | 236 | 304 | -68 |
| 1977-06-11 | vs TOR | 61 | L 4-5 | 24-37 | 7 | 21,318 | Glenn Abbott | Jerry Garvin | Jerry Johnson | Enrique Romo | | 240 | 309 | -69 |
| 1977-06-12 | vs TOR | 62 | W 5-2 | 25-37 | 7 | 28,412 | Dick Pole | Pete Vuckovich | Dick Pole | Pete Vuckovich | | 245 | 311 | -66 |
| 1977-06-14 | vs OAK | 63 | L 3-6 | 25-38 | 7 | 13,764 | Rick Jones | Doc Medich | Pablo Torrealba | Tom House | Bob Lacey | 248 | 317 | -69 |
| 1977-06-15 | vs OAK | 64 | W 6-5 | 26-38 | 7 | 14,248 | John Montague | Mike Norris | Mike Kekich | Pablo Torrealba | | 254 | 322 | -68 |
| 1977-06-16 | vs OAK | 65 | W 3-1 | 27-38 | 7 | 11,097 | Glenn Abbott | Rick Langford | Glenn Abbott | Rick Langford | | 257 | 323 | -66 |
| 1977-06-17 | @ TEX | 66 | W 2-1 | 28-39 | 7 | 0 | Dick Pole | Doyle Alexander | Dick Pole | Mike Marshall | Tom House | 259 | 324 | -65 |
| 1977-06-17 | @ TEX | 67 | L 6-8 | 28-39 | 7 | 21,577 | Gary Wheelock | Nelson Briles | Nelson Briles | Gary Wheelock | Adrian Devine | 265 | 332 | -67 |
| 1977-06-18 | @ TEX | 68 | W 6-1 | 29-39 | 7 | 17,352 | Rick Jones | Bert Blyleven | Rick Jones | Bert Blyleven | | 271 | 333 | -62 |
| 1977-06-19 | @ TEX | 69 | W 2-1 | 30-39 | 7 | 12,465 | Diego Segui | Gaylord Perry | Enrique Romo | Gaylord Perry | | 273 | 334 | -61 |
| 1977-06-20 | @ KCA | 70 | W 4-2 | 31-39 | 7 | 21,475 | Gary Wheelock | Dennis Leonard | Gary Wheelock | Dennis Leonard | Enrique Romo | 277 | 336 | -59 |
| 1977-06-21 | @ KCA | 71 | L 3-13 | 31-40 | 7 | 10,958 | Glenn Abbott | Jim Colborn | Jim Colborn | Glenn Abbott | | 280 | 349 | -69 |
| 1977-06-22 | @ KCA | 72 | L 3-4 | 31-41 | 7 | 22,140 | Dick Pole | Paul Splittorff | Doug Bird | Dick Pole | Mark Littell | 283 | 353 | -70 |
| 1977-06-23 | @ KCA | 73 | W 8-6 | 32-41 | 7 | 13,520 | Rick Jones | Andy Hassler | Enrique Romo | Mark Littell | | 291 | 359 | -68 |
| 1977-06-24 | @ MIL | 74 | L 1-7 | 32-42 | 7 | 11,625 | John Montague | Lary Sorensen | Lary Sorensen | John Montague | | 292 | 366 | -74 |
| 1977-06-25 | @ MIL | 75 | W 8-3 | 33-42 | 6 | 19,572 | Gary Wheelock | Moose Haas | Gary Wheelock | Moose Haas | Enrique Romo | 300 | 369 | -69 |
| 1977-06-26 | @ MIL | 76 | L 6-8 | 33-43 | 7 | 19,699 | Glenn Abbott | Jim Slaton | Mike Caldwell | Enrique Romo | | 306 | 377 | -71 |
| 1977-06-27 | @ CHA | 77 | L 4-10 | 33-44 | 7 | 16,026 | Dick Pole | Ken Kravec | Ken Kravec | Dick Pole | Bart Johnson | 310 | 387 | -77 |
| 1977-06-28 | @ CHA | 78 | L 4-10 | 33-45 | 7 | 8,365 | John Montague | Francisco Barrios | Francisco Barrios | John Montague | | 314 | 397 | -83 |
| 1977-06-29 | @ CHA | 79 | W 3-1 | 34-45 | 7 | 15,415 | Tom House | Wilbur Wood | Tom House | Wilbur Wood | Enrique Romo | 317 | 398 | -81 |
| 1977-07-01 | vs MIL | 80 | L 1-2 | 34-46 | 7 | 16,119 | Gary Wheelock | Moose Haas | Moose Haas | Gary Wheelock | | 318 | 400 | -82 |
| 1977-07-02 | vs MIL | 81 | W 2-1 | 35-46 | 7 | 24,466 | Glenn Abbott | Jim Slaton | Glenn Abbott | Jim Slaton | Mike Kekich | 320 | 401 | -81 |
| 1977-07-03 | vs MIL | 82 | L 3-10 | 35-47 | 7 | 16,226 | Dick Pole | Jerry Augustine | Jerry Augustine | Dick Pole | | 323 | 411 | -88 |
| 1977-07-04 | vs CHA | 83 | L 2-6 | 35-48 | 7 | 10,897 | John Montague | Francisco Barrios | Francisco Barrios | John Montague | | 325 | 417 | -92 |
| 1977-07-05 | vs CHA | 84 | L 1-4 | 35-49 | 7 | 14,032 | Tom House | Steve Stone | Steve Stone | Tom House | Lerrin LaGrow | 326 | 421 | -95 |
| 1977-07-06 | vs CHA | 85 | L 2-4 | 35-50 | 7 | 21,526 | Gary Wheelock | Wilbur Wood | Wilbur Wood | Gary Wheelock | | 328 | 425 | -97 |
| 1977-07-08 | @ MIN | 86 | W 13-11 | 36-50 | 7 | 11,966 | Glenn Abbott | Paul Thormodsgard | Bill Laxton | Paul Thormodsgard | Enrique Romo | 341 | 436 | -95 |
| 1977-07-09 | @ MIN | 87 | W 5-2 | 37-50 | 7 | 23,401 | Dick Pole | Dave Goltz | Dick Pole | Dave Goltz | Enrique Romo | 346 | 438 | -92 |
| 1977-07-10 | @ MIN | 88 | L 0-15 | 37-51 | 7 | 34,213 | Stan Thomas | Geoff Zahn | Geoff Zahn | Stan Thomas | | 346 | 453 | -107 |
| 1977-07-11 | @ OAK | 89 | L 1-8 | 37-52 | 7 | 8,760 | Tom House | Joe Coleman | Joe Coleman | Tom House | Bob Lacey | 347 | 461 | -114 |
| 1977-07-12 | @ OAK | 90 | L 2-3 | 37-53 | 7 | 5,299 | Gary Wheelock | Vida Blue | Vida Blue | Enrique Romo | | 349 | 464 | -115 |
| 1977-07-13 | @ OAK | 91 | W 3-1 | 38-53 | 7 | 4,529 | Glenn Abbott | Rick Langford | Glenn Abbott | Rick Langford | | 352 | 465 | -113 |
| 1977-07-14 | @ CAL | 92 | W 4-1 | 39-53 | 7 | 11,400 | Dick Pole | Ken Brett | Dick Pole | Ken Brett | Enrique Romo | 356 | 466 | -110 |
| 1977-07-15 | @ CAL | 93 | W 6-2 | 40-53 | 7 | 11,383 | Tom House | Gary Nolan | Tom House | Gary Nolan | | 362 | 468 | -106 |
| 1977-07-16 | @ CAL | 94 | L 4-5 | 40-54 | 7 | 29,068 | Diego Segui | Nolan Ryan | Nolan Ryan | Enrique Romo | | 366 | 473 | -107 |
| 1977-07-17 | @ CAL | 95 | W 8-7 | 41-54 | 7 | 10,879 | Gary Wheelock | Paul Hartzell | Mike Kekich | Dave LaRoche | | 374 | 480 | -106 |
| 1977-07-21 | vs OAK | 96 | W 4-3 | 42-54 | 6 | 17,382 | Glenn Abbott | Rick Langford | Glenn Abbott | Rick Langford | Enrique Romo | 378 | 483 | -105 |
| 1977-07-22 | vs OAK | 97 | L 3-5 | 42-55 | 7 | 13,960 | Dick Pole | Vida Blue | Vida Blue | Dick Pole | Bob Lacey | 381 | 488 | -107 |
| 1977-07-23 | vs OAK | 98 | W 10-3 | 43-55 | 6 | 12,216 | Gary Wheelock | Mike Norris | Gary Wheelock | Mike Norris | | 391 | 491 | -100 |
| 1977-07-24 | vs CAL | 99 | L 1-3 | 43-57 | 6 | 0 | Tom House | Paul Hartzell | Paul Hartzell | Tom House | Dyar Miller | 392 | 494 | -102 |
| 1977-07-24 | vs CAL | 100 | L 3-4 | 43-57 | 6 | 25,344 | Bob Galasso | Wayne Simpson | Wayne Simpson | Bob Galasso | Dave LaRoche | 395 | 498 | -103 |
| 1977-07-25 | vs CAL | 101 | L 2-7 | 43-58 | 6 | 10,886 | Dick Pole | Nolan Ryan | Nolan Ryan | Dick Pole | | 397 | 505 | -108 |
| 1977-07-26 | vs MIN | 102 | W 9-7 | 44-58 | 6 | 12,017 | Glenn Abbott | Paul Thormodsgard | Glenn Abbott | Paul Thormodsgard | Diego Segui | 406 | 512 | -106 |
| 1977-07-27 | vs MIN | 103 | L 1-4 | 44-59 | 6 | 16,869 | Tom House | Pete Redfern | Pete Redfern | Tom House | | 407 | 516 | -109 |
| 1977-07-28 | vs MIN | 104 | W 5-2 | 45-59 | 6 | 11,759 | Gary Wheelock | Geoff Zahn | Gary Wheelock | Geoff Zahn | John Montague | 412 | 518 | -106 |
| 1977-07-29 | vs BAL | 105 | L 4-5 | 45-60 | 6 | 14,313 | Bob Galasso | Mike Flanagan | Dick Drago | Mike Kekich | | 416 | 523 | -107 |
| 1977-07-30 | vs BAL | 106 | L 3-5 | 45-61 | 6 | 31,609 | Dick Pole | Ross Grimsley | Dennis Martinez | John Montague | | 419 | 528 | -109 |
| 1977-07-31 | vs BAL | 107 | W 6-1 | 46-61 | 6 | 11,464 | Glenn Abbott | Jim Palmer | Glenn Abbott | Jim Palmer | | 425 | 529 | -104 |
| 1977-08-02 | vs BOS | 108 | L 2-3 | 46-62 | 6 | 24,344 | Tom House | Rick Wise | Bill Campbell | John Montague | | 427 | 532 | -105 |
| 1977-08-03 | vs BOS | 109 | L 4-12 | 46-63 | 6 | 21,152 | Gary Wheelock | Mike Paxton | Mike Paxton | Gary Wheelock | | 431 | 544 | -113 |
| 1977-08-05 | vs NYA | 110 | W 5-3 | 47-63 | 6 | 36,833 | Dick Pole | Ed Figueroa | Dick Pole | Ed Figueroa | Enrique Romo | 436 | 547 | -111 |
| 1977-08-06 | vs NYA | 111 | W 9-2 | 48-63 | 6 | 42,146 | Glenn Abbott | Catfish Hunter | Glenn Abbott | Catfish Hunter | | 445 | 549 | -104 |
| 1977-08-07 | vs NYA | 112 | L 1-7 | 48-64 | 6 | 29,412 | Tom House | Mike Torrez | Mike Torrez | John Montague | | 446 | 556 | -110 |
| 1977-08-08 | @ CHA | 113 | L 4-5 | 48-65 | 6 | 17,047 | Bob Galasso | Francisco Barrios | Randy Wiles | Enrique Romo | | 450 | 561 | -111 |
| 1977-08-09 | @ CHA | 114 | L 3-13 | 48-66 | 6 | 12,294 | Gary Wheelock | Steve Stone | Steve Stone | Gary Wheelock | | 453 | 574 | -121 |
| 1977-08-10 | @ BAL | 115 | L 4-5 | 48-67 | 6 | 7,579 | Dick Pole | Rudy May | Rudy May | Dick Pole | Dick Drago | 457 | 579 | -122 |
| 1977-08-11 | @ BAL | 116 | L 3-4 | 48-68 | 6 | 7,893 | Glenn Abbott | Scott McGregor | Dick Drago | Enrique Romo | | 460 | 583 | -123 |
| 1977-08-12 | @ BOS | 117 | L 2-7 | 48-69 | 6 | 27,005 | Paul Mitchell | Rick Wise | Rick Wise | Paul Mitchell | | 462 | 590 | -128 |
| 1977-08-13 | @ BOS | 118 | L 6-13 | 48-70 | 6 | 34,095 | Bob Galasso | Fergie Jenkins | Fergie Jenkins | Bob Galasso | | 468 | 603 | -135 |
| 1977-08-14 | @ BOS | 119 | L 1-11 | 48-71 | 6 | 31,223 | Gary Wheelock | Mike Paxton | Mike Paxton | Gary Wheelock | | 469 | 614 | -145 |
| 1977-08-15 | @ DET | 120 | L 1-13 | 48-72 | 6 | 14,414 | Dick Pole | Bob Sykes | Bob Sykes | Dick Pole | | 470 | 627 | -157 |
| 1977-08-16 | @ DET | 121 | W 3-2 | 49-72 | 6 | 9,065 | Glenn Abbott | Jack Morris | Glenn Abbott | Jack Morris | | 473 | 629 | -156 |
| 1977-08-17 | @ MIN | 122 | W 3-2 | 50-72 | 6 | 11,739 | Paul Mitchell | Geoff Zahn | Paul Mitchell | Geoff Zahn | Enrique Romo | 476 | 631 | -155 |
| 1977-08-18 | @ MIN | 123 | L 2-8 | 50-73 | 6 | 13,884 | Bob Galasso | Paul Thormodsgard | Paul Thormodsgard | Bob Galasso | | 478 | 639 | -161 |
| 1977-08-19 | vs DET | 124 | L 4-6 | 50-74 | 6 | 19,698 | Dick Pole | Dave Rozema | Dave Rozema | Dick Pole | Bruce Taylor | 482 | 645 | -163 |
| 1977-08-20 | vs DET | 125 | L 3-7 | 50-75 | 6 | 55,670 | Glenn Abbott | Milt Wilcox | Milt Wilcox | Glenn Abbott | | 485 | 652 | -167 |
| 1977-08-21 | vs DET | 126 | L 4-5 | 50-76 | 6 | 15,373 | Paul Mitchell | Jack Morris | Jim Crawford | Paul Mitchell | John Hiller | 489 | 657 | -168 |
| 1977-08-22 | vs CLE | 127 | L 1-12 | 51-77 | 6 | 0 | Bob Galasso | Jim Bibby | Jim Bibby | Bob Galasso | | 490 | 669 | -179 |
| 1977-08-22 | vs CLE | 128 | W 4-3 | 51-77 | 6 | 12,347 | John Montague | Wayne Garland | John Montague | Wayne Garland | | 494 | 672 | -178 |
| 1977-08-24 | vs TOR | 129 | L 0-7 | 51-79 | 6 | 0 | Dick Pole | Jerry Garvin | Jerry Garvin | Dick Pole | | 494 | 679 | -185 |
| 1977-08-24 | vs TOR | 130 | L 3-9 | 51-79 | 6 | 13,253 | Glenn Abbott | Jesse Jefferson | Jesse Jefferson | Glenn Abbott | | 497 | 688 | -191 |
| 1977-08-26 | @ CLE | 131 | W 4-2 | 52-79 | 6 | 6,707 | Paul Mitchell | Wayne Garland | Enrique Romo | Jim Kern | | 501 | 690 | -189 |
| 1977-08-27 | @ CLE | 132 | L 0-10 | 52-80 | 6 | 7,876 | Bob Galasso | Dennis Eckersley | Dennis Eckersley | Bob Galasso | | 501 | 700 | -199 |
| 1977-08-28 | @ CLE | 133 | L 6-10 | 52-81 | 7 | 9,599 | Glenn Abbott | Jim Bibby | Jim Bibby | Glenn Abbott | | 507 | 710 | -203 |
| 1977-08-30 | @ NYA | 134 | L 5-6 | 52-82 | 7 | 20,116 | Dick Pole | Ed Figueroa | Sparky Lyle | Diego Segui | | 512 | 716 | -204 |
| 1977-08-31 | @ NYA | 135 | L 4-5 | 52-83 | 7 | 17,362 | Rick Honeycutt | Mike Torrez | Sparky Lyle | Bob Galasso | | 516 | 721 | -205 |
| 1977-09-02 | @ TOR | 136 | W 4-3 | 53-83 | 7 | 13,502 | Glenn Abbott | Dave Lemanczyk | Glenn Abbott | Dave Lemanczyk | | 520 | 724 | -204 |
| 1977-09-03 | @ TOR | 137 | W 6-2 | 54-83 | 6 | 15,109 | John Montague | Jesse Jefferson | John Montague | Jesse Jefferson | Enrique Romo | 526 | 726 | -200 |
| 1977-09-04 | @ TOR | 138 | W 7-2 | 55-83 | 6 | 17,084 | Paul Mitchell | Jerry Garvin | Paul Mitchell | Jerry Garvin | | 533 | 728 | -195 |
| 1977-09-05 | vs KCA | 139 | L 4-8 | 55-84 | 7 | 11,750 | Dick Pole | Jim Colborn | Jim Colborn | Dick Pole | | 537 | 736 | -199 |
| 1977-09-06 | vs KCA | 140 | L 0-10 | 55-85 | 7 | 7,191 | Rick Honeycutt | Paul Splittorff | Paul Splittorff | Rick Honeycutt | | 537 | 746 | -209 |
| 1977-09-07 | vs KCA | 141 | L 7-10 | 55-86 | 7 | 7,814 | Glenn Abbott | Andy Hassler | Mark Littell | Enrique Romo | Doug Bird | 544 | 756 | -212 |
| 1977-09-08 | vs KCA | 142 | L 2-7 | 55-87 | 7 | 7,785 | John Montague | Dennis Leonard | Dennis Leonard | John Montague | | 546 | 763 | -217 |
| 1977-09-09 | vs TEX | 143 | W 8-3 | 56-87 | 6 | 8,245 | Tom House | Gaylord Perry | Tom House | Gaylord Perry | | 554 | 766 | -212 |
| 1977-09-10 | vs TEX | 144 | L 2-5 | 56-89 | 7 | 0 | Paul Mitchell | Doyle Alexander | Doyle Alexander | Paul Mitchell | | 556 | 771 | -215 |
| 1977-09-10 | vs TEX | 145 | L 1-7 | 56-89 | 7 | 12,800 | Mike Kekich | Roger Moret | Roger Moret | Mike Kekich | | 557 | 778 | -221 |
| 1977-09-11 | vs TEX | 146 | W 6-4 | 57-89 | 7 | 8,363 | Rick Honeycutt | Adrian Devine | Enrique Romo | Paul Lindblad | | 563 | 782 | -219 |
| 1977-09-13 | vs MIL | 147 | L 5-6 | 57-90 | 7 | 7,595 | Glenn Abbott | Jim Slaton | Gary Beare | Glenn Abbott | Bob McClure | 568 | 788 | -220 |
| 1977-09-14 | vs MIL | 148 | L 5-8 | 57-91 | 7 | 5,718 | John Montague | Jerry Augustine | Eduardo Rodriguez | Greg Erardi | | 573 | 796 | -223 |
| 1977-09-16 | @ KCA | 149 | W 4-1 | 58-91 | 7 | 19,072 | Doc Medich | Marty Pattin | Doc Medich | Marty Pattin | | 577 | 797 | -220 |
| 1977-09-17 | @ KCA | 150 | L 5-7 | 58-92 | 7 | 27,067 | Paul Mitchell | Mark Littell | Larry Gura | Diego Segui | | 582 | 804 | -222 |
| 1977-09-18 | @ KCA | 151 | L 3-8 | 58-93 | 7 | 33,397 | Glenn Abbott | Dennis Leonard | Dennis Leonard | Glenn Abbott | | 585 | 812 | -227 |
| 1977-09-20 | @ MIL | 152 | L 1-5 | 58-94 | 7 | 3,004 | John Montague | Jim Slaton | Jim Slaton | John Montague | | 586 | 817 | -231 |
| 1977-09-21 | @ MIL | 153 | W 11-4 | 59-94 | 7 | 3,008 | Doc Medich | Jerry Augustine | Enrique Romo | Jerry Augustine | | 597 | 821 | -224 |
| 1977-09-22 | vs CHA | 154 | L 4-5 | 59-95 | 7 | 8,211 | Paul Mitchell | Steve Renko | Steve Renko | Steve Burke | Lerrin LaGrow | 601 | 826 | -225 |
| 1977-09-23 | vs CHA | 155 | W 3-2 | 60-95 | 7 | 9,731 | Tom House | Francisco Barrios | Tom House | Francisco Barrios | John Montague | 604 | 828 | -224 |
| 1977-09-24 | vs CHA | 156 | L 3-8 | 60-96 | 7 | 17,636 | Diego Segui | Ken Kravec | Ken Kravec | Diego Segui | | 607 | 836 | -229 |
| 1977-09-25 | vs CHA | 157 | W 5-4 | 61-96 | 6 | 11,589 | Doc Medich | Steve Stone | Doc Medich | Steve Stone | Enrique Romo | 612 | 840 | -228 |
| 1977-09-28 | @ TEX | 158 | L 1-3 | 61-97 | 7 | 4,860 | Glenn Abbott | Gaylord Perry | Gaylord Perry | Glenn Abbott | | 613 | 843 | -230 |
| 1977-09-29 | @ TEX | 159 | W 2-1 | 62-97 | 7 | 4,714 | Paul Mitchell | Doyle Alexander | Paul Mitchell | Doyle Alexander | Enrique Romo | 615 | 844 | -229 |
| 1977-10-01 | @ CHA | 160 | W 5-3 | 63-98 | 7 | 0 | Tom House | Francisco Barrios | John Montague | Francisco Barrios | Enrique Romo | 620 | 847 | -227 |
| 1977-10-01 | @ CHA | 161 | L 1-6 | 63-98 | 7 | 5,778 | Mike Kekich | Ken Kravec | Ken Kravec | Mike Kekich | | 621 | 853 | -232 |
| 1977-10-02 | @ CHA | 162 | W 3-2 | 64-98 | 6 | 20,953 | Glenn Abbott | Dave Frost | Glenn Abbott | Dave Frost | Enrique Romo | 624 | 855 | -231 |