| 1977-04-06 | @ CIN | 1 | L 3-5 | 0-1 | 5 | 51,937 | Randy Jones | Woodie Fryman | Woodie Fryman | Randy Jones | Rawly Eastwick | 3 | 5 | -2 |
| 1977-04-08 | @ CIN | 2 | L 3-6 | 0-2 | 5 | 24,588 | Brent Strom | Jack Billingham | Jack Billingham | Brent Strom | Dale Murray | 6 | 11 | -5 |
| 1977-04-09 | @ CIN | 3 | W 6-3 | 1-2 | 4 | 21,101 | Dave Freisleben | Fred Norman | Rollie Fingers | Rawly Eastwick | | 12 | 14 | -2 |
| 1977-04-10 | @ CIN | 4 | W 12-4 | 2-2 | 4 | 37,504 | Bob Shirley | Santo Alcala | Bob Shirley | Santo Alcala | | 24 | 18 | 6 |
| 1977-04-12 | vs SFN | 5 | W 4-3 | 3-2 | 3 | 45,375 | Randy Jones | Lynn McGlothen | Randy Jones | Lynn McGlothen | Rollie Fingers | 28 | 21 | 7 |
| 1977-04-13 | vs SFN | 6 | L 1-3 | 3-3 | 3 | 13,230 | Rick Sawyer | John Montefusco | John Montefusco | Rick Sawyer | | 29 | 24 | 5 |
| 1977-04-14 | vs SFN | 7 | L 4-8 | 3-4 | 4 | 17,743 | Dave Freisleben | Jim Barr | Jim Barr | Dave Freisleben | | 33 | 32 | 1 |
| 1977-04-15 | vs CIN | 8 | L 5-9 | 3-5 | 6 | 28,330 | Brent Strom | Fred Norman | Santo Alcala | Dave Freisleben | Rawly Eastwick | 38 | 41 | -3 |
| 1977-04-16 | vs CIN | 9 | W 5-4 | 4-5 | 4 | 41,029 | Randy Jones | Woodie Fryman | Rollie Fingers | Rawly Eastwick | | 43 | 45 | -2 |
| 1977-04-17 | vs CIN | 10 | L 1-4 | 4-6 | 5 | 42,142 | Bob Shirley | Pat Zachry | Pat Zachry | Bob Shirley | | 44 | 49 | -5 |
| 1977-04-18 | @ ATL | 11 | W 12-6 | 5-6 | 4 | 3,933 | Rick Sawyer | Frank LaCorte | Rick Sawyer | Frank LaCorte | | 56 | 55 | 1 |
| 1977-04-19 | @ ATL | 12 | L 1-4 | 5-7 | 4 | 7,635 | Dave Freisleben | Dick Ruthven | Dick Ruthven | Dave Freisleben | | 57 | 59 | -2 |
| 1977-04-20 | @ ATL | 13 | L 0-2 | 5-8 | 5 | 8,176 | Randy Jones | Andy Messersmith | Andy Messersmith | Randy Jones | Rick Camp | 57 | 61 | -4 |
| 1977-04-22 | @ HOU | 14 | W 4-2 | 6-8 | 3 | 6,106 | Bob Shirley | J.R. Richard | Bob Shirley | J.R. Richard | Rollie Fingers | 61 | 63 | -2 |
| 1977-04-23 | @ HOU | 15 | W 7-2 | 8-8 | 3 | 0 | Tom Griffin | Joaquin Andujar | Tom Griffin | Joaquin Andujar | Dave Tomlin | 68 | 65 | 3 |
| 1977-04-23 | @ HOU | 16 | W 11-8 | 8-8 | 3 | 26,224 | Butch Metzger | Floyd Bannister | Victor Bernal | Dan Larson | Rollie Fingers | 79 | 73 | 6 |
| 1977-04-24 | @ HOU | 17 | L 8-9 | 8-9 | 4 | 6,362 | Rick Sawyer | Doug Konieczny | Joe Sambito | Rollie Fingers | | 87 | 82 | 5 |
| 1977-04-25 | vs LAN | 18 | L 3-7 | 8-10 | 4 | 27,910 | Randy Jones | Rick Rhoden | Rick Rhoden | Randy Jones | | 90 | 89 | 1 |
| 1977-04-26 | vs LAN | 19 | L 1-4 | 8-11 | 5 | 24,481 | Bob Shirley | Don Sutton | Don Sutton | Bob Shirley | Charlie Hough | 91 | 93 | -2 |
| 1977-04-27 | vs LAN | 20 | L 6-7 | 8-12 | 6 | 18,132 | Tom Griffin | Doug Rau | Doug Rau | Tom Griffin | Charlie Hough | 97 | 100 | -3 |
| 1977-04-28 | vs LAN | 21 | L 5-7 | 8-13 | 6 | 12,036 | Dave Freisleben | Burt Hooton | Burt Hooton | Dave Freisleben | Mike Garman | 102 | 107 | -5 |
| 1977-04-29 | vs NYN | 22 | L 2-9 | 8-14 | 6 | 43,497 | Rick Sawyer | Jon Matlack | Jon Matlack | Rick Sawyer | | 104 | 116 | -12 |
| 1977-04-30 | vs NYN | 23 | L 1-4 | 8-15 | 6 | 22,428 | Randy Jones | Tom Seaver | Tom Seaver | Randy Jones | | 105 | 120 | -15 |
| 1977-05-01 | vs NYN | 24 | L 2-8 | 8-16 | 6 | 14,220 | Bob Shirley | Craig Swan | Craig Swan | Bob Shirley | Skip Lockwood | 107 | 128 | -21 |
| 1977-05-02 | vs PHI | 25 | W 4-3 | 9-16 | 6 | 16,112 | Tom Griffin | Wayne Twitchell | Rollie Fingers | Ron Reed | | 111 | 131 | -20 |
| 1977-05-03 | vs PHI | 26 | L 7-8 | 9-17 | 6 | 7,942 | Rick Sawyer | Steve Carlton | Gene Garber | Victor Bernal | | 118 | 139 | -21 |
| 1977-05-04 | vs PHI | 27 | W 4-1 | 10-17 | 5 | 10,021 | Randy Jones | Jim Kaat | Randy Jones | Jim Kaat | | 122 | 140 | -18 |
| 1977-05-05 | vs PHI | 28 | L 5-8 | 10-18 | 5 | 7,810 | Bob Shirley | Randy Lerch | Randy Lerch | Bob Shirley | Gene Garber | 127 | 148 | -21 |
| 1977-05-06 | vs MON | 29 | W 6-4 | 11-18 | 5 | 9,992 | Tom Griffin | Jackie Brown | Tom Griffin | Jackie Brown | Rollie Fingers | 133 | 152 | -19 |
| 1977-05-07 | vs MON | 30 | L 6-7 | 11-19 | 5 | 41,869 | Rick Sawyer | Don Stanhouse | Don Stanhouse | Rick Sawyer | Joe Kerrigan | 139 | 159 | -20 |
| 1977-05-11 | @ NYN | 31 | W 6-3 | 13-19 | 4 | 0 | Bob Shirley | Tom Seaver | Dan Spillner | Tom Seaver | Rollie Fingers | 145 | 162 | -17 |
| 1977-05-11 | @ NYN | 32 | W 4-3 | 13-19 | 4 | 7,518 | Randy Jones | Craig Swan | Randy Jones | Craig Swan | Dave Tomlin | 149 | 165 | -16 |
| 1977-05-12 | @ NYN | 33 | W 5-2 | 14-19 | 3 | 6,071 | Tom Griffin | Jerry Koosman | Tom Griffin | Jerry Koosman | Rollie Fingers | 154 | 167 | -13 |
| 1977-05-13 | @ PHI | 34 | L 4-5 | 14-20 | 5 | 23,655 | Rick Sawyer | Wayne Twitchell | Ron Reed | Dave Tomlin | Gene Garber | 158 | 172 | -14 |
| 1977-05-14 | @ PHI | 35 | L 5-9 | 14-21 | 5 | 26,609 | Brent Strom | Jim Kaat | Tom Underwood | Brent Strom | Gene Garber | 163 | 181 | -18 |
| 1977-05-15 | @ PHI | 36 | L 2-5 | 14-22 | 5 | 46,141 | Randy Jones | Steve Carlton | Steve Carlton | Randy Jones | | 165 | 186 | -21 |
| 1977-05-16 | @ CHN | 37 | L 6-9 | 14-23 | 5 | 6,992 | Bob Shirley | Donnie Moore | Jim Todd | Bob Shirley | Paul Reuschel | 171 | 195 | -24 |
| 1977-05-17 | @ CHN | 38 | L 6-23 | 14-24 | 5 | 9,838 | Tom Griffin | Bill Bonham | Bill Bonham | Tom Griffin | Ramon Hernandez | 177 | 218 | -41 |
| 1977-05-19 | @ MON | 39 | W 5-2 | 15-24 | 5 | 14,861 | Randy Jones | Don Stanhouse | Randy Jones | Don Stanhouse | Rollie Fingers | 182 | 220 | -38 |
| 1977-05-20 | @ MON | 40 | W 12-4 | 16-24 | 5 | 13,122 | Bob Shirley | Gerry Hannahs | Bob Shirley | Gerry Hannahs | Dan Spillner | 194 | 224 | -30 |
| 1977-05-21 | @ MON | 41 | W 11-8 | 17-24 | 4 | 16,892 | Bob Owchinko | Dan Warthen | Rick Sawyer | Jeff Terpko | | 205 | 232 | -27 |
| 1977-05-22 | @ MON | 42 | L 1-3 | 17-25 | 5 | 17,045 | John D'Acquisto | Steve Rogers | Steve Rogers | John D'Acquisto | | 206 | 235 | -29 |
| 1977-05-23 | vs ATL | 43 | L 5-6 | 17-26 | 5 | 9,497 | Tom Griffin | Phil Niekro | Buzz Capra | Dave Tomlin | | 211 | 241 | -30 |
| 1977-05-24 | vs ATL | 44 | W 4-3 | 18-26 | 4 | 7,277 | Bob Shirley | Frank LaCorte | Rick Sawyer | Frank LaCorte | Rollie Fingers | 215 | 244 | -29 |
| 1977-05-25 | vs ATL | 45 | W 6-5 | 19-26 | 4 | 14,288 | Bob Owchinko | Max Leon | Tom Griffin | Jamie Easterly | | 221 | 249 | -28 |
| 1977-05-26 | vs ATL | 46 | L 3-8 | 19-27 | 4 | 13,786 | John D'Acquisto | Andy Messersmith | Andy Messersmith | Tom Griffin | | 224 | 257 | -33 |
| 1977-05-27 | vs HOU | 47 | L 3-4 | 19-28 | 5 | 13,147 | Rick Sawyer | Bo McLaughlin | Bo McLaughlin | Rick Sawyer | Ken Forsch | 227 | 261 | -34 |
| 1977-05-28 | vs HOU | 48 | W 6-5 | 20-28 | 4 | 42,222 | Bob Shirley | Floyd Bannister | Bob Shirley | Floyd Bannister | Rollie Fingers | 233 | 266 | -33 |
| 1977-05-29 | vs HOU | 49 | W 3-2 | 21-28 | 4 | 14,058 | Randy Jones | Mark Lemongello | Dan Spillner | Mark Lemongello | Rollie Fingers | 236 | 268 | -32 |
| 1977-05-30 | @ SFN | 50 | W 12-8 | 23-28 | 3 | 0 | Bob Owchinko | Lynn McGlothen | Rick Sawyer | Lynn McGlothen | Rollie Fingers | 248 | 276 | -28 |
| 1977-05-30 | @ SFN | 51 | W 9-8 | 23-28 | 3 | 25,807 | John D'Acquisto | Bob Knepper | Dave Wehrmeister | Randy Moffitt | Rollie Fingers | 257 | 284 | -27 |
| 1977-05-31 | @ SFN | 52 | W 4-2 | 24-28 | 3 | 2,107 | Tom Griffin | Jim Barr | Dave Tomlin | Jim Barr | Rollie Fingers | 261 | 286 | -25 |
| 1977-06-01 | @ SFN | 53 | L 0-2 | 24-29 | 3 | 2,890 | Bob Shirley | Ed Halicki | Ed Halicki | Bob Shirley | | 261 | 288 | -27 |
| 1977-06-03 | @ LAN | 54 | W 1-0 | 25-29 | 3 | 43,691 | Randy Jones | Don Sutton | Rollie Fingers | Charlie Hough | | 262 | 288 | -26 |
| 1977-06-04 | @ LAN | 55 | L 4-9 | 25-30 | 3 | 37,014 | Bob Owchinko | Rick Rhoden | Rick Rhoden | Dave Wehrmeister | Mike Garman | 266 | 297 | -31 |
| 1977-06-05 | @ LAN | 56 | L 2-4 | 25-31 | 3 | 42,697 | Tom Griffin | Doug Rau | Doug Rau | Tom Griffin | Charlie Hough | 268 | 301 | -33 |
| 1977-06-06 | @ SLN | 57 | L 3-4 | 25-32 | 4 | 10,429 | Bob Shirley | John Denny | Clay Carroll | Dave Tomlin | | 271 | 305 | -34 |
| 1977-06-07 | @ SLN | 58 | W 9-5 | 26-32 | 4 | 14,238 | John D'Acquisto | Larry Dierker | Bob Owchinko | Larry Dierker | Rollie Fingers | 280 | 310 | -30 |
| 1977-06-08 | @ SLN | 59 | L 0-3 | 26-33 | 4 | 8,611 | Randy Jones | Eric Rasmussen | Eric Rasmussen | Randy Jones | | 280 | 313 | -33 |
| 1977-06-10 | @ PIT | 60 | L 7-10 | 26-34 | 4 | 10,499 | Tom Griffin | Odell Jones | Rich Gossage | Rollie Fingers | | 287 | 323 | -36 |
| 1977-06-11 | @ PIT | 61 | W 4-1 | 27-34 | 3 | 11,262 | Bob Shirley | John Candelaria | Bob Shirley | John Candelaria | Rollie Fingers | 291 | 324 | -33 |
| 1977-06-12 | @ PIT | 62 | L 1-6 | 27-36 | 4 | 0 | Randy Jones | Jerry Reuss | Jerry Reuss | Randy Jones | | 292 | 330 | -38 |
| 1977-06-12 | @ PIT | 63 | L 4-7 | 27-36 | 4 | 21,640 | Bob Owchinko | Bruce Kison | Bruce Kison | Rick Sawyer | Rich Gossage | 296 | 337 | -41 |
| 1977-06-14 | vs CHN | 64 | L 5-6 | 27-37 | 4 | 15,801 | Tom Griffin | Bill Bonham | Donnie Moore | Rollie Fingers | | 301 | 343 | -42 |
| 1977-06-15 | vs CHN | 65 | L 0-2 | 27-38 | 4 | 14,931 | Bob Owchinko | Rick Reuschel | Rick Reuschel | Bob Owchinko | | 301 | 345 | -44 |
| 1977-06-16 | vs CHN | 66 | W 8-6 | 28-38 | 4 | 10,748 | Bob Shirley | Ray Burris | Bob Shirley | Ray Burris | Dan Spillner | 309 | 351 | -42 |
| 1977-06-17 | vs SLN | 67 | W 4-3 | 29-38 | 4 | 19,518 | Randy Jones | John Denny | John D'Acquisto | John Denny | Rollie Fingers | 313 | 354 | -41 |
| 1977-06-18 | vs SLN | 68 | W 4-1 | 30-38 | 4 | 35,702 | Tom Griffin | Eric Rasmussen | Tom Griffin | Eric Rasmussen | Dave Tomlin | 317 | 355 | -38 |
| 1977-06-19 | vs SLN | 69 | W 6-2 | 31-38 | 4 | 17,682 | Bob Owchinko | Bob Forsch | Bob Owchinko | Bob Forsch | | 323 | 357 | -34 |
| 1977-06-20 | vs PIT | 70 | L 3-5 | 31-39 | 4 | 26,030 | Bob Shirley | Odell Jones | Kent Tekulve | Bob Shirley | Rich Gossage | 326 | 362 | -36 |
| 1977-06-21 | vs PIT | 71 | L 2-9 | 31-40 | 4 | 14,265 | John D'Acquisto | John Candelaria | John Candelaria | Dave Tomlin | | 328 | 371 | -43 |
| 1977-06-22 | vs PIT | 72 | L 1-3 | 31-41 | 4 | 14,624 | Tom Griffin | Jerry Reuss | Jerry Reuss | Tom Griffin | Rich Gossage | 329 | 374 | -45 |
| 1977-06-24 | @ ATL | 73 | L 8-9 | 31-42 | 5 | 8,210 | Bob Owchinko | Steve Hargan | Rick Camp | Dave Wehrmeister | | 337 | 383 | -46 |
| 1977-06-25 | @ ATL | 74 | L 5-9 | 31-43 | 5 | 10,958 | Bob Shirley | Andy Messersmith | Andy Messersmith | Bob Shirley | | 342 | 392 | -50 |
| 1977-06-26 | @ ATL | 75 | L 5-8 | 31-44 | 5 | 13,484 | Dave Freisleben | Phil Niekro | Phil Niekro | Dave Freisleben | Max Leon | 347 | 400 | -53 |
| 1977-06-27 | @ HOU | 76 | L 6-7 | 31-45 | 5 | 7,458 | Tom Griffin | Floyd Bannister | Joe Niekro | Rollie Fingers | | 353 | 407 | -54 |
| 1977-06-28 | @ HOU | 77 | L 1-5 | 31-46 | 5 | 8,196 | Bob Owchinko | Joaquin Andujar | Joaquin Andujar | Bob Owchinko | | 354 | 412 | -58 |
| 1977-06-29 | @ HOU | 78 | W 7-4 | 32-46 | 5 | 8,367 | John D'Acquisto | Dan Larson | Dave Freisleben | Dan Larson | Dan Spillner | 361 | 416 | -55 |
| 1977-07-01 | vs CIN | 79 | L 1-2 | 32-47 | 5 | 19,884 | Bob Shirley | Fred Norman | Fred Norman | Bob Shirley | | 362 | 418 | -56 |
| 1977-07-02 | vs CIN | 80 | L 3-6 | 32-48 | 5 | 21,981 | Bob Owchinko | Paul Moskau | Dale Murray | Bob Owchinko | Pedro Borbon | 365 | 424 | -59 |
| 1977-07-03 | vs CIN | 81 | W 8-7 | 33-48 | 5 | 21,265 | Dave Freisleben | Jack Billingham | Dan Spillner | Jack Billingham | Rollie Fingers | 373 | 431 | -58 |
| 1977-07-04 | vs HOU | 82 | L 7-12 | 33-49 | 5 | 35,735 | Tom Griffin | Joaquin Andujar | Joe Niekro | Tom Griffin | | 380 | 443 | -63 |
| 1977-07-05 | vs HOU | 83 | W 8-7 | 34-49 | 5 | 7,019 | John D'Acquisto | Dan Larson | Rollie Fingers | Joe Niekro | | 388 | 450 | -62 |
| 1977-07-06 | @ SFN | 84 | W 7-5 | 35-49 | 5 | 2,597 | Bob Shirley | Charlie Williams | Dan Spillner | Dave Heaverlo | | 395 | 455 | -60 |
| 1977-07-07 | @ SFN | 85 | L 1-5 | 35-50 | 5 | 3,181 | Bob Owchinko | Bob Knepper | Bob Knepper | Bob Owchinko | | 396 | 460 | -64 |
| 1977-07-08 | @ LAN | 86 | L 3-5 | 35-51 | 5 | 52,851 | Tom Griffin | Burt Hooton | Burt Hooton | Tom Griffin | | 399 | 465 | -66 |
| 1977-07-09 | @ LAN | 87 | W 2-1 | 36-51 | 5 | 39,102 | Dave Freisleben | Don Sutton | Dave Freisleben | Charlie Hough | Rollie Fingers | 401 | 466 | -65 |
| 1977-07-10 | @ LAN | 88 | W 7-5 | 38-51 | 5 | 0 | Dave Wehrmeister | Al Downing | Rollie Fingers | Charlie Hough | | 408 | 471 | -63 |
| 1977-07-10 | @ LAN | 89 | W 5-4 | 38-51 | 5 | 51,575 | John D'Acquisto | Rick Rhoden | Rick Sawyer | Rick Rhoden | Rollie Fingers | 413 | 475 | -62 |
| 1977-07-11 | vs SFN | 90 | L 1-5 | 38-52 | 5 | 11,109 | Bob Shirley | Bob Knepper | Bob Knepper | Bob Shirley | Randy Moffitt | 414 | 480 | -66 |
| 1977-07-12 | vs SFN | 91 | W 7-3 | 39-52 | 5 | 10,708 | Bob Owchinko | Jim Barr | Bob Owchinko | Jim Barr | Dan Spillner | 421 | 483 | -62 |
| 1977-07-13 | vs SFN | 92 | L 4-5 | 39-53 | 5 | 11,000 | Tom Griffin | Ed Halicki | Ed Halicki | Tom Griffin | Gary Lavelle | 425 | 488 | -63 |
| 1977-07-15 | vs LAN | 93 | W 5-3 | 40-53 | 5 | 31,726 | Dave Freisleben | Rick Rhoden | Dan Spillner | Rick Rhoden | Rollie Fingers | 430 | 491 | -61 |
| 1977-07-16 | vs LAN | 94 | L 0-1 | 40-54 | 5 | 37,684 | Bob Owchinko | Tommy John | Tommy John | Bob Owchinko | | 430 | 492 | -62 |
| 1977-07-17 | vs LAN | 95 | L 3-4 | 40-55 | 5 | 28,477 | Bob Shirley | Doug Rau | Doug Rau | Bob Shirley | Burt Hooton | 433 | 496 | -63 |
| 1977-07-21 | vs NYN | 96 | W 3-2 | 41-55 | 5 | 9,757 | Dave Freisleben | Pat Zachry | Rollie Fingers | Skip Lockwood | | 436 | 498 | -62 |
| 1977-07-22 | vs NYN | 97 | L 0-5 | 41-56 | 5 | 23,935 | Tom Griffin | Jon Matlack | Jon Matlack | Tom Griffin | | 436 | 503 | -67 |
| 1977-07-23 | vs NYN | 98 | W 4-3 | 42-56 | 5 | 19,656 | John D'Acquisto | Jerry Koosman | Dave Tomlin | Skip Lockwood | Rollie Fingers | 440 | 506 | -66 |
| 1977-07-24 | vs PHI | 99 | L 4-7 | 42-57 | 5 | 12,695 | Bob Owchinko | Jim Kaat | Jim Kaat | Bob Owchinko | Ron Reed | 444 | 513 | -69 |
| 1977-07-25 | vs PHI | 100 | L 4-6 | 42-58 | 5 | 10,999 | Bob Shirley | Randy Lerch | Tug McGraw | Dan Spillner | | 448 | 519 | -71 |
| 1977-07-26 | vs MON | 101 | W 4-3 | 43-59 | 5 | 0 | Dave Freisleben | Jackie Brown | Dave Freisleben | Joe Kerrigan | | 452 | 522 | -70 |
| 1977-07-26 | vs MON | 102 | L 2-5 | 43-59 | 5 | 13,176 | Dave Wehrmeister | Santo Alcala | Don Stanhouse | Dan Spillner | | 454 | 527 | -73 |
| 1977-07-27 | vs MON | 103 | W 7-5 | 44-59 | 5 | 8,037 | Rick Sawyer | Stan Bahnsen | Tom Griffin | Stan Bahnsen | | 461 | 532 | -71 |
| 1977-07-28 | vs MON | 104 | L 4-5 | 44-60 | 5 | 7,010 | Bob Owchinko | Wayne Twitchell | Joe Kerrigan | Bob Owchinko | Don Stanhouse | 465 | 537 | -72 |
| 1977-07-29 | @ NYN | 105 | L 1-4 | 44-61 | 5 | 13,431 | Bob Shirley | Jerry Koosman | Jerry Koosman | Bob Shirley | Skip Lockwood | 466 | 541 | -75 |
| 1977-07-30 | @ NYN | 106 | W 8-6 | 45-61 | 5 | 20,407 | Dave Freisleben | Nino Espinosa | Dave Freisleben | Nino Espinosa | Rollie Fingers | 474 | 547 | -73 |
| 1977-07-31 | @ NYN | 107 | L 9-10 | 45-62 | 5 | 13,386 | Dave Wehrmeister | Craig Swan | Craig Swan | Dave Wehrmeister | Skip Lockwood | 483 | 557 | -74 |
| 1977-08-02 | @ PHI | 108 | W 4-2 | 46-62 | 5 | 30,204 | Bob Owchinko | Jim Kaat | Bob Owchinko | Jim Kaat | Rollie Fingers | 487 | 559 | -72 |
| 1977-08-03 | @ PHI | 109 | L 1-8 | 46-63 | 5 | 27,053 | Bob Shirley | Steve Carlton | Steve Carlton | Bob Shirley | | 488 | 567 | -79 |
| 1977-08-04 | @ PHI | 110 | L 1-2 | 46-64 | 5 | 34,868 | Dave Freisleben | Larry Christenson | Tug McGraw | Dan Spillner | | 489 | 569 | -80 |
| 1977-08-05 | @ CHN | 111 | W 11-8 | 47-64 | 5 | 17,985 | Dave Wehrmeister | Ray Burris | Dave Tomlin | Ray Burris | Rollie Fingers | 500 | 577 | -77 |
| 1977-08-06 | @ CHN | 112 | L 5-10 | 47-65 | 5 | 21,146 | Randy Jones | Bill Bonham | Bill Bonham | Randy Jones | Paul Reuschel | 505 | 587 | -82 |
| 1977-08-07 | @ CHN | 113 | W 8-6 | 48-66 | 5 | 0 | Bob Owchinko | Mike Krukow | Bob Owchinko | Mike Krukow | Dan Spillner | 513 | 593 | -80 |
| 1977-08-07 | @ CHN | 114 | L 4-9 | 48-66 | 5 | 30,099 | Bob Shirley | Steve Renko | Steve Renko | Bob Shirley | | 517 | 602 | -85 |
| 1977-08-08 | @ MON | 115 | L 5-6 | 48-67 | 5 | 22,613 | Dave Wehrmeister | Stan Bahnsen | Don Stanhouse | Bob Shirley | Joe Kerrigan | 522 | 608 | -86 |
| 1977-08-09 | @ MON | 116 | W 8-3 | 49-67 | 5 | 23,907 | Dave Freisleben | Wayne Twitchell | Dave Freisleben | Wayne Twitchell | Rollie Fingers | 530 | 611 | -81 |
| 1977-08-10 | vs ATL | 117 | W 8-6 | 51-67 | 5 | 0 | Randy Jones | Phil Niekro | Randy Jones | Phil Niekro | Rollie Fingers | 538 | 617 | -79 |
| 1977-08-10 | vs ATL | 118 | W 2-1 | 51-67 | 5 | 19,533 | Tom Griffin | Buzz Capra | Rick Sawyer | Duane Theiss | | 540 | 618 | -78 |
| 1977-08-11 | vs ATL | 119 | W 2-1 | 52-67 | 5 | 11,116 | Bob Owchinko | Preston Hanna | Rick Sawyer | Preston Hanna | | 542 | 619 | -77 |
| 1977-08-12 | vs HOU | 120 | W 5-4 | 53-67 | 5 | 13,697 | Dave Wehrmeister | Tom Dixon | Rollie Fingers | Ken Forsch | | 547 | 623 | -76 |
| 1977-08-14 | vs HOU | 121 | L 3-6 | 53-68 | 5 | 13,181 | Dave Freisleben | Joe Niekro | Joe Niekro | Dave Freisleben | | 550 | 629 | -79 |
| 1977-08-15 | @ CIN | 122 | L 0-3 | 53-69 | 5 | 29,729 | Randy Jones | Jack Billingham | Jack Billingham | Randy Jones | Pedro Borbon | 550 | 632 | -82 |
| 1977-08-16 | @ CIN | 123 | L 1-5 | 53-70 | 5 | 30,610 | Bob Owchinko | Tom Seaver | Tom Seaver | Bob Owchinko | | 551 | 637 | -86 |
| 1977-08-17 | @ CIN | 124 | W 7-4 | 54-70 | 5 | 29,795 | Bob Shirley | Mario Soto | Bob Shirley | Mario Soto | Rollie Fingers | 558 | 641 | -83 |
| 1977-08-19 | @ SLN | 125 | L 4-12 | 54-71 | 5 | 21,529 | Dave Freisleben | John Urrea | John Urrea | Dave Freisleben | | 562 | 653 | -91 |
| 1977-08-20 | @ SLN | 126 | L 1-7 | 54-72 | 5 | 35,982 | Randy Jones | Eric Rasmussen | Eric Rasmussen | Randy Jones | | 563 | 660 | -97 |
| 1977-08-21 | @ SLN | 127 | W 7-0 | 55-72 | 5 | 30,343 | Bob Owchinko | Tom Underwood | Bob Owchinko | Tom Underwood | | 570 | 660 | -90 |
| 1977-08-22 | @ PIT | 128 | W 1-0 | 56-72 | 5 | 7,375 | Bob Shirley | Jim Rooker | Bob Shirley | Jim Rooker | Rollie Fingers | 571 | 660 | -89 |
| 1977-08-23 | @ PIT | 129 | L 6-7 | 56-73 | 5 | 8,105 | Dave Freisleben | Jerry Reuss | Rich Gossage | Rollie Fingers | | 577 | 667 | -90 |
| 1977-08-26 | vs PIT | 130 | L 1-3 | 56-74 | 5 | 18,696 | Bob Owchinko | Bruce Kison | Bruce Kison | Bob Owchinko | Rich Gossage | 578 | 670 | -92 |
| 1977-08-27 | vs PIT | 131 | L 0-4 | 56-75 | 5 | 14,732 | Randy Jones | Jerry Reuss | Jerry Reuss | Randy Jones | | 578 | 674 | -96 |
| 1977-08-28 | vs PIT | 132 | L 1-10 | 56-76 | 5 | 10,371 | Bob Shirley | Jim Rooker | Jim Rooker | Bob Shirley | | 579 | 684 | -105 |
| 1977-08-29 | vs SLN | 133 | W 4-3 | 57-76 | 5 | 19,656 | Dave Freisleben | John Urrea | Dave Freisleben | Al Hrabosky | Rollie Fingers | 583 | 687 | -104 |
| 1977-08-30 | vs SLN | 134 | W 7-4 | 58-76 | 5 | 9,432 | Bob Owchinko | Eric Rasmussen | Bob Owchinko | Eric Rasmussen | Dan Spillner | 590 | 691 | -101 |
| 1977-08-31 | vs SLN | 135 | W 2-1 | 59-76 | 5 | 8,269 | Bob Shirley | Tom Underwood | Bob Shirley | Tom Underwood | Rollie Fingers | 592 | 692 | -100 |
| 1977-09-02 | vs CHN | 136 | W 5-0 | 60-76 | 5 | 10,717 | Randy Jones | Mike Krukow | Randy Jones | Mike Krukow | Rollie Fingers | 597 | 692 | -95 |
| 1977-09-03 | vs CHN | 137 | W 4-1 | 61-76 | 5 | 10,970 | Dave Freisleben | Rick Reuschel | Dan Spillner | Rick Reuschel | | 601 | 693 | -92 |
| 1977-09-04 | vs CHN | 138 | L 1-2 | 61-77 | 5 | 15,506 | Bob Shirley | Ray Burris | Ray Burris | Dan Spillner | Bruce Sutter | 602 | 695 | -93 |
| 1977-09-05 | vs LAN | 139 | W 1-0 | 62-77 | 5 | 25,343 | Bob Owchinko | Doug Rau | Bob Owchinko | Doug Rau | | 603 | 695 | -92 |
| 1977-09-06 | vs LAN | 140 | L 2-3 | 62-78 | 5 | 12,827 | Randy Jones | Rick Rhoden | Elias Sosa | Dan Spillner | Charlie Hough | 605 | 698 | -93 |
| 1977-09-07 | @ HOU | 141 | W 9-5 | 63-78 | 5 | 5,120 | Dave Freisleben | J.R. Richard | Dave Freisleben | J.R. Richard | Rollie Fingers | 614 | 703 | -89 |
| 1977-09-08 | @ HOU | 142 | L 1-7 | 63-79 | 5 | 3,697 | Bob Shirley | Floyd Bannister | Floyd Bannister | Bob Shirley | | 615 | 710 | -95 |
| 1977-09-09 | @ ATL | 143 | L 6-8 | 63-80 | 5 | 1,740 | Tom Griffin | Preston Hanna | Preston Hanna | Rick Sawyer | Dave Campbell | 621 | 718 | -97 |
| 1977-09-10 | @ ATL | 144 | L 6-9 | 63-81 | 5 | 7,967 | Bob Owchinko | Dick Ruthven | Dick Ruthven | Bob Owchinko | | 627 | 727 | -100 |
| 1977-09-11 | @ ATL | 145 | L 3-7 | 63-82 | 5 | 2,376 | Randy Jones | Eddie Solomon | Eddie Solomon | Randy Jones | Dave Campbell | 630 | 734 | -104 |
| 1977-09-12 | @ LAN | 146 | L 6-7 | 63-83 | 5 | 19,547 | Dave Freisleben | Don Sutton | Bobby Castillo | Rollie Fingers | | 636 | 741 | -105 |
| 1977-09-13 | @ LAN | 147 | L 4-18 | 63-84 | 5 | 19,442 | Bob Shirley | Dennis Lewallyn | Dennis Lewallyn | Bob Shirley | | 640 | 759 | -119 |
| 1977-09-14 | vs ATL | 148 | W 6-4 | 64-84 | 5 | 12,478 | Bob Owchinko | Preston Hanna | Dan Spillner | Preston Hanna | Rollie Fingers | 646 | 763 | -117 |
| 1977-09-15 | vs ATL | 149 | L 7-8 | 64-85 | 5 | 3,740 | Randy Jones | Dick Ruthven | Buzz Capra | Rollie Fingers | | 653 | 771 | -118 |
| 1977-09-16 | vs HOU | 150 | W 4-3 | 65-85 | 5 | 7,046 | John D'Acquisto | Joaquin Andujar | Dave Tomlin | Joe Niekro | | 657 | 774 | -117 |
| 1977-09-17 | vs HOU | 151 | L 0-11 | 65-86 | 5 | 8,463 | Dave Freisleben | J.R. Richard | J.R. Richard | Dave Freisleben | | 657 | 785 | -128 |
| 1977-09-20 | vs CIN | 152 | L 0-4 | 65-87 | 5 | 11,302 | Bob Owchinko | Tom Seaver | Tom Seaver | Bob Owchinko | | 657 | 789 | -132 |
| 1977-09-21 | vs CIN | 153 | L 2-3 | 65-88 | 5 | 11,669 | Randy Jones | Fred Norman | Dale Murray | Rollie Fingers | | 659 | 792 | -133 |
| 1977-09-22 | vs CIN | 154 | W 3-1 | 66-88 | 5 | 6,370 | Bob Shirley | Doug Capilla | Bob Shirley | Doug Capilla | Rollie Fingers | 662 | 793 | -131 |
| 1977-09-23 | vs SFN | 155 | L 4-6 | 66-89 | 5 | 5,271 | John D'Acquisto | Jim Barr | Dave Heaverlo | Dan Spillner | | 666 | 799 | -133 |
| 1977-09-24 | vs SFN | 156 | L 2-3 | 66-90 | 5 | 7,777 | Dave Freisleben | John Montefusco | Charlie Williams | Rollie Fingers | Randy Moffitt | 668 | 802 | -134 |
| 1977-09-25 | vs SFN | 157 | W 9-2 | 67-90 | 5 | 17,379 | Bob Owchinko | Bob Knepper | Bob Owchinko | Bob Knepper | | 677 | 804 | -127 |
| 1977-09-27 | @ CIN | 158 | W 3-1 | 68-90 | 5 | 13,652 | Bob Shirley | Fred Norman | Bob Shirley | Fred Norman | Rollie Fingers | 680 | 805 | -125 |
| 1977-09-28 | @ CIN | 159 | L 0-8 | 68-91 | 5 | 13,010 | John D'Acquisto | Paul Moskau | Paul Moskau | John D'Acquisto | | 680 | 813 | -133 |
| 1977-09-30 | @ SFN | 160 | L 5-7 | 68-92 | 5 | 1,864 | Dave Freisleben | Bob Knepper | Bob Knepper | Dave Freisleben | Dave Heaverlo | 685 | 820 | -135 |
| 1977-10-01 | @ SFN | 161 | L 4-13 | 68-93 | 5 | 2,549 | Bob Owchinko | Ed Halicki | Ed Halicki | Bob Owchinko | | 689 | 833 | -144 |
| 1977-10-02 | @ SFN | 162 | W 3-1 | 69-93 | 5 | 17,320 | Bob Shirley | Jim Barr | Bob Shirley | Jim Barr | | 692 | 834 | -142 |