| 1977-04-09 | vs MON | 1 | L 3-4 | 0-1 | 5 | 43,367 | Steve Carlton | Steve Rogers | Jackie Brown | Steve Carlton | | 3 | 4 | -1 |
| 1977-04-10 | vs MON | 2 | L 8-9 | 0-2 | 5 | 14,354 | Larry Christenson | Don Stanhouse | Bill Atkinson | Gene Garber | Joe Kerrigan | 11 | 13 | -2 |
| 1977-04-11 | vs CHN | 3 | L 2-6 | 0-3 | 5 | 17,578 | Wayne Twitchell | Bill Bonham | Bill Bonham | Wayne Twitchell | | 13 | 19 | -6 |
| 1977-04-13 | vs CHN | 4 | L 1-3 | 0-4 | 6 | 16,434 | Randy Lerch | Ray Burris | Ray Burris | Randy Lerch | Bruce Sutter | 14 | 22 | -8 |
| 1977-04-15 | @ MON | 5 | W 7-2 | 1-4 | 6 | 57,592 | Steve Carlton | Don Stanhouse | Steve Carlton | Don Stanhouse | | 21 | 24 | -3 |
| 1977-04-16 | @ MON | 6 | L 3-4 | 1-5 | 6 | 18,361 | Larry Christenson | Gerry Hannahs | Gerry Hannahs | Larry Christenson | Bill Atkinson | 24 | 28 | -4 |
| 1977-04-17 | @ MON | 7 | L 1-2 | 1-6 | 6 | 29,115 | Wayne Twitchell | Steve Rogers | Will McEnaney | Gene Garber | | 25 | 30 | -5 |
| 1977-04-18 | @ CHN | 8 | W 3-1 | 2-6 | 6 | 3,777 | Randy Lerch | Ray Burris | Randy Lerch | Ray Burris | Ron Reed | 28 | 31 | -3 |
| 1977-04-19 | @ CHN | 9 | W 7-5 | 3-6 | 6 | 2,413 | Larry Christenson | Mike Krukow | Larry Christenson | Mike Krukow | Gene Garber | 35 | 36 | -1 |
| 1977-04-22 | vs SLN | 10 | L 1-10 | 3-7 | 6 | 26,430 | Wayne Twitchell | John Denny | John Denny | Wayne Twitchell | | 36 | 46 | -10 |
| 1977-04-23 | vs SLN | 11 | W 11-1 | 4-7 | 6 | 27,642 | Randy Lerch | Bob Forsch | Randy Lerch | Bob Forsch | | 47 | 47 | 0 |
| 1977-04-24 | vs SLN | 12 | W 6-3 | 5-7 | 6 | 40,186 | Steve Carlton | Pete Falcone | Steve Carlton | Pete Falcone | | 53 | 50 | 3 |
| 1977-04-26 | @ PIT | 13 | L 0-5 | 5-8 | 6 | 6,726 | Larry Christenson | John Candelaria | John Candelaria | Larry Christenson | Rich Gossage | 53 | 55 | -2 |
| 1977-04-27 | @ PIT | 14 | L 3-7 | 5-9 | 6 | 7,054 | Wayne Twitchell | Bruce Kison | Bruce Kison | Wayne Twitchell | | 56 | 62 | -6 |
| 1977-04-29 | @ SFN | 15 | W 6-5 | 6-9 | 6 | 4,440 | Steve Carlton | Jim Barr | Steve Carlton | Jim Barr | Ron Reed | 62 | 67 | -5 |
| 1977-04-30 | @ SFN | 16 | W 6-4 | 7-9 | 6 | 6,216 | Randy Lerch | Ed Halicki | Randy Lerch | Ed Halicki | Ron Reed | 68 | 71 | -3 |
| 1977-05-01 | @ SFN | 17 | W 7-2 | 8-9 | 6 | 16,272 | Larry Christenson | Lynn McGlothen | Larry Christenson | Lynn McGlothen | | 75 | 73 | 2 |
| 1977-05-02 | @ SDN | 18 | L 3-4 | 8-10 | 6 | 16,112 | Wayne Twitchell | Tom Griffin | Rollie Fingers | Ron Reed | | 78 | 77 | 1 |
| 1977-05-03 | @ SDN | 19 | W 8-7 | 9-10 | 5 | 7,942 | Steve Carlton | Rick Sawyer | Gene Garber | Victor Bernal | | 86 | 84 | 2 |
| 1977-05-04 | @ SDN | 20 | L 1-4 | 9-11 | 5 | 10,021 | Jim Kaat | Randy Jones | Randy Jones | Jim Kaat | | 87 | 88 | -1 |
| 1977-05-05 | @ SDN | 21 | W 8-5 | 10-11 | 5 | 7,810 | Randy Lerch | Bob Shirley | Randy Lerch | Bob Shirley | Gene Garber | 95 | 93 | 2 |
| 1977-05-06 | @ LAN | 22 | L 3-9 | 10-12 | 5 | 51,368 | Larry Christenson | Don Sutton | Don Sutton | Larry Christenson | | 98 | 102 | -4 |
| 1977-05-07 | @ LAN | 23 | W 7-4 | 11-12 | 5 | 38,910 | Wayne Twitchell | Doug Rau | Tom Underwood | Al Downing | | 105 | 106 | -1 |
| 1977-05-10 | vs SFN | 24 | W 3-0 | 12-12 | 5 | 16,121 | Steve Carlton | Terry Cornutt | Steve Carlton | Terry Cornutt | | 108 | 106 | 2 |
| 1977-05-11 | vs SFN | 25 | L 2-4 | 12-13 | 5 | 18,482 | Randy Lerch | Lynn McGlothen | Lynn McGlothen | Randy Lerch | | 110 | 110 | 0 |
| 1977-05-12 | vs SFN | 26 | W 3-0 | 13-13 | 5 | 23,103 | Larry Christenson | John Montefusco | Larry Christenson | John Montefusco | | 113 | 110 | 3 |
| 1977-05-13 | vs SDN | 27 | W 5-4 | 14-13 | 4 | 23,655 | Wayne Twitchell | Rick Sawyer | Ron Reed | Dave Tomlin | Gene Garber | 118 | 114 | 4 |
| 1977-05-14 | vs SDN | 28 | W 9-5 | 15-13 | 4 | 26,609 | Jim Kaat | Brent Strom | Tom Underwood | Brent Strom | Gene Garber | 127 | 119 | 8 |
| 1977-05-15 | vs SDN | 29 | W 5-2 | 16-13 | 4 | 46,141 | Steve Carlton | Randy Jones | Steve Carlton | Randy Jones | | 132 | 121 | 11 |
| 1977-05-16 | vs LAN | 30 | W 10-6 | 17-13 | 4 | 28,036 | Randy Lerch | Tommy John | Randy Lerch | Tommy John | Ron Reed | 142 | 127 | 15 |
| 1977-05-17 | vs LAN | 31 | L 4-6 | 17-14 | 4 | 30,292 | Larry Christenson | Don Sutton | Don Sutton | Larry Christenson | Charlie Hough | 146 | 133 | 13 |
| 1977-05-18 | vs LAN | 32 | L 4-6 | 17-15 | 4 | 30,132 | Wayne Twitchell | Rick Rhoden | Rick Rhoden | Wayne Twitchell | Charlie Hough | 150 | 139 | 11 |
| 1977-05-19 | @ HOU | 33 | L 2-3 | 17-16 | 4 | 5,605 | Jim Kaat | Joaquin Andujar | Joaquin Andujar | Gene Garber | Joe Sambito | 152 | 142 | 10 |
| 1977-05-20 | @ HOU | 34 | L 2-5 | 17-17 | 4 | 8,892 | Steve Carlton | J.R. Richard | J.R. Richard | Steve Carlton | | 154 | 147 | 7 |
| 1977-05-21 | @ HOU | 35 | W 7-4 | 18-17 | 4 | 21,154 | Randy Lerch | Bo McLaughlin | Ron Reed | Dan Larson | | 161 | 151 | 10 |
| 1977-05-22 | @ HOU | 36 | W 6-3 | 19-17 | 4 | 8,624 | Larry Christenson | Floyd Bannister | Larry Christenson | Floyd Bannister | Warren Brusstar | 167 | 154 | 13 |
| 1977-05-24 | @ SLN | 37 | L 5-8 | 19-18 | 4 | 11,415 | Jim Kaat | Bob Forsch | Bob Forsch | Jim Kaat | Al Hrabosky | 172 | 162 | 10 |
| 1977-05-25 | @ SLN | 38 | W 2-1 | 20-18 | 4 | 12,401 | Steve Carlton | Pete Falcone | Steve Carlton | Pete Falcone | Tom Underwood | 174 | 163 | 11 |
| 1977-05-26 | @ SLN | 39 | L 3-4 | 20-19 | 4 | 16,450 | Randy Lerch | John Denny | Butch Metzger | Ron Reed | | 177 | 167 | 10 |
| 1977-05-27 | vs NYN | 40 | W 5-4 | 21-19 | 4 | 28,365 | Larry Christenson | Tom Seaver | Gene Garber | Skip Lockwood | | 182 | 171 | 11 |
| 1977-05-28 | vs NYN | 41 | W 4-2 | 22-19 | 4 | 31,234 | Jim Lonborg | Jerry Koosman | Ron Reed | Skip Lockwood | | 186 | 173 | 13 |
| 1977-05-29 | vs NYN | 42 | W 7-6 | 23-19 | 4 | 43,279 | Jim Kaat | Jon Matlack | Jim Kaat | Jon Matlack | Gene Garber | 193 | 179 | 14 |
| 1977-05-30 | vs PIT | 43 | W 6-4 | 24-19 | 4 | 32,253 | Steve Carlton | Bruce Kison | Steve Carlton | Bruce Kison | | 199 | 183 | 16 |
| 1977-05-31 | vs PIT | 44 | W 6-5 | 25-19 | 4 | 23,731 | Randy Lerch | Larry Demery | Ron Reed | Kent Tekulve | | 205 | 188 | 17 |
| 1977-06-01 | vs PIT | 45 | L 0-3 | 25-20 | 4 | 28,234 | Larry Christenson | John Candelaria | John Candelaria | Larry Christenson | | 205 | 191 | 14 |
| 1977-06-03 | @ NYN | 46 | W 1-0 | 26-20 | 4 | 20,013 | Jim Lonborg | Jon Matlack | Jim Lonborg | Jon Matlack | Ron Reed | 206 | 191 | 15 |
| 1977-06-04 | @ NYN | 47 | L 0-2 | 26-21 | 4 | 16,460 | Steve Carlton | Nino Espinosa | Nino Espinosa | Steve Carlton | Skip Lockwood | 206 | 193 | 13 |
| 1977-06-05 | @ NYN | 48 | L 5-6 | 26-23 | 4 | 0 | Randy Lerch | Jackson Todd | Bob Apodaca | Tom Underwood | | 211 | 199 | 12 |
| 1977-06-05 | @ NYN | 49 | L 2-3 | 26-23 | 4 | 30,867 | Jim Kaat | Craig Swan | Craig Swan | Jim Kaat | Skip Lockwood | 213 | 202 | 11 |
| 1977-06-06 | vs HOU | 50 | W 9-5 | 27-23 | 4 | 17,326 | Larry Christenson | Bo McLaughlin | Larry Christenson | Bo McLaughlin | Warren Brusstar | 222 | 207 | 15 |
| 1977-06-07 | vs HOU | 51 | W 9-8 | 28-23 | 4 | 25,226 | Jim Lonborg | Floyd Bannister | Tom Underwood | Joe Niekro | Gene Garber | 231 | 215 | 16 |
| 1977-06-08 | vs HOU | 52 | W 3-2 | 29-23 | 4 | 23,388 | Steve Carlton | Mark Lemongello | Steve Carlton | Mark Lemongello | | 234 | 217 | 17 |
| 1977-06-09 | @ ATL | 53 | L 0-3 | 29-24 | 4 | 6,791 | Jim Kaat | Phil Niekro | Phil Niekro | Jim Kaat | | 234 | 220 | 14 |
| 1977-06-10 | @ ATL | 54 | W 7-5 | 30-24 | 4 | 9,274 | Randy Lerch | Max Leon | Ron Reed | Dave Campbell | Gene Garber | 241 | 225 | 16 |
| 1977-06-11 | @ ATL | 55 | W 13-10 | 31-24 | 4 | 12,760 | Larry Christenson | Joey McLaughlin | Warren Brusstar | Buzz Capra | Gene Garber | 254 | 235 | 19 |
| 1977-06-12 | @ ATL | 56 | L 3-5 | 31-25 | 4 | 15,716 | Jim Lonborg | Andy Messersmith | Rick Camp | Gene Garber | | 257 | 240 | 17 |
| 1977-06-13 | @ CIN | 57 | L 4-5 | 31-26 | 4 | 27,147 | Steve Carlton | Woodie Fryman | Pedro Borbon | Wayne Twitchell | | 261 | 245 | 16 |
| 1977-06-14 | @ CIN | 58 | L 2-3 | 31-27 | 4 | 30,036 | Jim Kaat | Fred Norman | Fred Norman | Jim Kaat | | 263 | 248 | 15 |
| 1977-06-15 | @ CIN | 59 | L 7-8 | 31-28 | 4 | 31,214 | Randy Lerch | Gary Nolan | Pedro Borbon | Tom Underwood | | 270 | 256 | 14 |
| 1977-06-17 | vs ATL | 60 | W 11-5 | 32-28 | 4 | 37,143 | Larry Christenson | Andy Messersmith | Larry Christenson | Andy Messersmith | Ron Reed | 281 | 261 | 20 |
| 1977-06-18 | vs ATL | 61 | W 8-5 | 33-28 | 4 | 32,016 | Jim Lonborg | Phil Niekro | Tug McGraw | Frank LaCorte | | 289 | 266 | 23 |
| 1977-06-19 | vs ATL | 62 | W 4-2 | 34-28 | 2 | 40,126 | Steve Carlton | Steve Hargan | Steve Carlton | Steve Hargan | | 293 | 268 | 25 |
| 1977-06-20 | vs CIN | 63 | W 10-4 | 35-28 | 2 | 38,121 | Jim Kaat | Fred Norman | Jim Kaat | Fred Norman | | 303 | 272 | 31 |
| 1977-06-21 | vs CIN | 64 | L 5-10 | 35-29 | 2 | 45,091 | Randy Lerch | Paul Moskau | Pedro Borbon | Warren Brusstar | | 308 | 282 | 26 |
| 1977-06-22 | vs CIN | 65 | W 15-9 | 36-29 | 2 | 47,148 | Larry Christenson | Jack Billingham | Tug McGraw | Tom Hume | | 323 | 291 | 32 |
| 1977-06-24 | @ SLN | 66 | L 1-7 | 36-30 | 3 | 17,885 | Jim Lonborg | Eric Rasmussen | Eric Rasmussen | Jim Lonborg | | 324 | 298 | 26 |
| 1977-06-25 | @ SLN | 67 | L 2-3 | 36-31 | 4 | 33,244 | Steve Carlton | Bob Forsch | Bob Forsch | Steve Carlton | Rawly Eastwick | 326 | 301 | 25 |
| 1977-06-26 | @ SLN | 68 | W 2-0 | 37-31 | 3 | 31,167 | Jim Kaat | Larry Dierker | Jim Kaat | Larry Dierker | Gene Garber | 328 | 301 | 27 |
| 1977-06-27 | @ NYN | 69 | W 4-2 | 38-31 | 2 | 17,800 | Randy Lerch | Nino Espinosa | Tug McGraw | Skip Lockwood | | 332 | 303 | 29 |
| 1977-06-28 | @ NYN | 70 | W 3-1 | 39-31 | 2 | 13,913 | Larry Christenson | Craig Swan | Ron Reed | Rick Baldwin | Tug McGraw | 335 | 304 | 31 |
| 1977-06-29 | @ NYN | 71 | L 3-5 | 39-32 | 2 | 12,434 | Jim Lonborg | Jerry Koosman | Jerry Koosman | Jim Lonborg | Skip Lockwood | 338 | 309 | 29 |
| 1977-06-30 | vs PIT | 72 | W 8-1 | 40-32 | 2 | 36,162 | Steve Carlton | Odell Jones | Steve Carlton | Odell Jones | | 346 | 310 | 36 |
| 1977-07-01 | vs PIT | 73 | W 7-6 | 41-32 | 2 | 34,640 | Jim Kaat | John Candelaria | Gene Garber | Grant Jackson | | 353 | 316 | 37 |
| 1977-07-02 | vs PIT | 74 | W 4-3 | 42-32 | 2 | 41,828 | Randy Lerch | Jerry Reuss | Warren Brusstar | Jerry Reuss | Ron Reed | 357 | 319 | 38 |
| 1977-07-03 | vs PIT | 75 | W 11-7 | 43-32 | 2 | 28,555 | Larry Christenson | Bruce Kison | Larry Christenson | Bruce Kison | | 368 | 326 | 42 |
| 1977-07-04 | vs NYN | 76 | W 3-1 | 44-32 | 2 | 63,283 | Jim Lonborg | Jerry Koosman | Jim Lonborg | Jerry Koosman | Ron Reed | 371 | 327 | 44 |
| 1977-07-05 | vs NYN | 77 | W 12-1 | 45-32 | 2 | 23,344 | Steve Carlton | Pat Zachry | Steve Carlton | Pat Zachry | | 383 | 328 | 55 |
| 1977-07-06 | vs NYN | 78 | W 5-3 | 46-32 | 2 | 23,185 | Jim Kaat | Jon Matlack | Gene Garber | Jon Matlack | Tug McGraw | 388 | 331 | 57 |
| 1977-07-07 | vs NYN | 79 | W 6-4 | 47-32 | 2 | 27,492 | Randy Lerch | Nino Espinosa | Warren Brusstar | Nino Espinosa | Ron Reed | 394 | 335 | 59 |
| 1977-07-08 | @ PIT | 80 | L 7-8 | 47-33 | 2 | 25,200 | Larry Christenson | Bruce Kison | Rich Gossage | Warren Brusstar | | 401 | 343 | 58 |
| 1977-07-09 | @ PIT | 81 | L 8-9 | 47-34 | 2 | 19,144 | Steve Carlton | John Candelaria | Terry Forster | Gene Garber | | 409 | 352 | 57 |
| 1977-07-10 | @ PIT | 82 | L 1-5 | 47-36 | 2 | 0 | Jim Lonborg | Jerry Reuss | Jerry Reuss | Jim Lonborg | | 410 | 357 | 53 |
| 1977-07-10 | @ PIT | 83 | L 10-12 | 47-36 | 2 | 39,042 | Jim Kaat | Jim Rooker | Grant Jackson | Ron Reed | Rich Gossage | 420 | 369 | 51 |
| 1977-07-12 | vs SLN | 84 | W 5-4 | 48-36 | 2 | 32,618 | Randy Lerch | Eric Rasmussen | Randy Lerch | Rawly Eastwick | | 425 | 373 | 52 |
| 1977-07-13 | vs SLN | 85 | W 5-2 | 49-36 | 2 | 36,828 | Steve Carlton | Tom Underwood | Steve Carlton | Tom Underwood | Tug McGraw | 430 | 375 | 55 |
| 1977-07-14 | vs SLN | 86 | L 6-7 | 49-37 | 2 | 33,601 | Jim Kaat | Bob Forsch | Rawly Eastwick | Tug McGraw | Al Hrabosky | 436 | 382 | 54 |
| 1977-07-15 | vs CHN | 87 | W 4-2 | 51-37 | 2 | 0 | Larry Christenson | Bill Bonham | Larry Christenson | Bill Bonham | Tug McGraw | 440 | 384 | 56 |
| 1977-07-15 | vs CHN | 88 | W 9-2 | 51-37 | 2 | 61,177 | Jim Lonborg | Mike Krukow | Jim Lonborg | Mike Krukow | | 449 | 386 | 63 |
| 1977-07-16 | vs CHN | 89 | L 8-9 | 51-38 | 2 | 35,095 | Randy Lerch | Rick Reuschel | Pete Broberg | Ron Reed | Bruce Sutter | 457 | 395 | 62 |
| 1977-07-17 | vs CHN | 90 | W 4-2 | 52-38 | 2 | 36,338 | Steve Carlton | Ray Burris | Steve Carlton | Ray Burris | Tug McGraw | 461 | 397 | 64 |
| 1977-07-21 | @ SFN | 91 | W 9-6 | 53-38 | 2 | 5,771 | Jim Lonborg | Ed Halicki | Jim Lonborg | Charlie Williams | Gene Garber | 470 | 403 | 67 |
| 1977-07-22 | @ SFN | 92 | L 2-6 | 53-39 | 2 | 6,064 | Steve Carlton | John Montefusco | John Montefusco | Steve Carlton | Gary Lavelle | 472 | 409 | 63 |
| 1977-07-23 | @ SFN | 93 | W 6-3 | 54-39 | 2 | 7,958 | Larry Christenson | Bob Knepper | Larry Christenson | Bob Knepper | Tug McGraw | 478 | 412 | 66 |
| 1977-07-24 | @ SDN | 94 | W 7-4 | 55-39 | 2 | 12,695 | Jim Kaat | Bob Owchinko | Jim Kaat | Bob Owchinko | Ron Reed | 485 | 416 | 69 |
| 1977-07-25 | @ SDN | 95 | W 6-4 | 56-39 | 2 | 10,999 | Randy Lerch | Bob Shirley | Tug McGraw | Dan Spillner | | 491 | 420 | 71 |
| 1977-07-26 | @ LAN | 96 | L 1-5 | 57-40 | 2 | 0 | Steve Carlton | Rick Rhoden | Rick Rhoden | Steve Carlton | Mike Garman | 492 | 425 | 67 |
| 1977-07-26 | @ LAN | 97 | W 5-1 | 57-40 | 2 | 47,966 | Jim Lonborg | Burt Hooton | Jim Lonborg | Burt Hooton | | 497 | 426 | 71 |
| 1977-07-27 | @ LAN | 98 | L 5-7 | 57-41 | 2 | 38,571 | Larry Christenson | Don Sutton | Lance Rautzhan | Tug McGraw | Mike Garman | 502 | 433 | 69 |
| 1977-07-28 | @ LAN | 99 | L 1-2 | 57-42 | 3 | 33,260 | Jim Kaat | Tommy John | Tommy John | Jim Kaat | | 503 | 435 | 68 |
| 1977-07-29 | vs SFN | 100 | L 0-7 | 57-43 | 3 | 32,449 | Randy Lerch | Jim Barr | Jim Barr | Randy Lerch | | 503 | 442 | 61 |
| 1977-07-30 | vs SFN | 101 | W 9-3 | 58-43 | 3 | 35,197 | Steve Carlton | Lynn McGlothen | Steve Carlton | Lynn McGlothen | Gene Garber | 512 | 445 | 67 |
| 1977-07-31 | vs SFN | 102 | W 5-4 | 59-43 | 2 | 42,013 | Jim Lonborg | Ed Halicki | Tug McGraw | Gary Lavelle | Ron Reed | 517 | 449 | 68 |
| 1977-08-02 | vs SDN | 103 | L 2-4 | 59-44 | 2 | 30,204 | Jim Kaat | Bob Owchinko | Bob Owchinko | Jim Kaat | Rollie Fingers | 519 | 453 | 66 |
| 1977-08-03 | vs SDN | 104 | W 8-1 | 60-44 | 2 | 27,053 | Steve Carlton | Bob Shirley | Steve Carlton | Bob Shirley | | 527 | 454 | 73 |
| 1977-08-04 | vs SDN | 105 | W 2-1 | 61-44 | 2 | 34,868 | Larry Christenson | Dave Freisleben | Tug McGraw | Dan Spillner | | 529 | 455 | 74 |
| 1977-08-05 | vs LAN | 106 | W 8-3 | 62-44 | 2 | 47,574 | Jim Lonborg | Rick Rhoden | Gene Garber | Lance Rautzhan | | 537 | 458 | 79 |
| 1977-08-06 | vs LAN | 107 | W 1-0 | 63-44 | 2 | 50,111 | Jim Kaat | Burt Hooton | Gene Garber | Burt Hooton | | 538 | 458 | 80 |
| 1977-08-07 | vs LAN | 108 | W 3-1 | 64-44 | 2 | 40,628 | Steve Carlton | Don Sutton | Steve Carlton | Don Sutton | | 541 | 459 | 82 |
| 1977-08-10 | vs MON | 109 | W 6-1 | 66-44 | 1 | 0 | Larry Christenson | Steve Rogers | Larry Christenson | Steve Rogers | | 547 | 460 | 87 |
| 1977-08-10 | vs MON | 110 | W 6-1 | 66-44 | 1 | 46,664 | Jim Lonborg | Santo Alcala | Jim Lonborg | Santo Alcala | | 553 | 461 | 92 |
| 1977-08-11 | vs MON | 111 | W 10-5 | 67-44 | 1 | 30,267 | Jim Kaat | Jackie Brown | Jim Kaat | Jackie Brown | Gene Garber | 563 | 466 | 97 |
| 1977-08-12 | @ CHN | 112 | W 10-3 | 68-44 | 1 | 28,849 | Steve Carlton | Rick Reuschel | Steve Carlton | Rick Reuschel | | 573 | 469 | 104 |
| 1977-08-13 | @ CHN | 113 | W 10-7 | 69-44 | 1 | 27,126 | Randy Lerch | Ray Burris | Ron Reed | Dave Giusti | Gene Garber | 583 | 476 | 107 |
| 1977-08-14 | @ CHN | 114 | W 10-2 | 71-44 | 1 | 0 | Larry Christenson | Mike Krukow | Larry Christenson | Mike Krukow | | 593 | 478 | 115 |
| 1977-08-14 | @ CHN | 115 | W 4-2 | 71-44 | 1 | 33,351 | Jim Lonborg | Steve Renko | Jim Lonborg | Steve Renko | Ron Reed | 597 | 480 | 117 |
| 1977-08-16 | @ MON | 116 | W 7-5 | 72-44 | 1 | 15,234 | Jim Kaat | Jackie Brown | Warren Brusstar | Joe Kerrigan | Gene Garber | 604 | 485 | 119 |
| 1977-08-17 | @ MON | 117 | L 0-13 | 72-45 | 1 | 22,398 | Steve Carlton | Stan Bahnsen | Stan Bahnsen | Steve Carlton | | 604 | 498 | 106 |
| 1977-08-18 | @ MON | 118 | W 8-3 | 73-45 | 1 | 18,296 | Jim Lonborg | Wayne Twitchell | Jim Lonborg | Wayne Twitchell | | 612 | 501 | 111 |
| 1977-08-19 | vs HOU | 119 | W 9-5 | 74-45 | 1 | 46,266 | Larry Christenson | Joe Niekro | Larry Christenson | Joe Niekro | | 621 | 506 | 115 |
| 1977-08-20 | vs HOU | 120 | W 5-4 | 75-45 | 1 | 47,048 | Jim Kaat | Dan Larson | Tug McGraw | Bo McLaughlin | | 626 | 510 | 116 |
| 1977-08-21 | vs HOU | 121 | W 7-3 | 76-45 | 1 | 46,852 | Steve Carlton | Mark Lemongello | Steve Carlton | Mark Lemongello | | 633 | 513 | 120 |
| 1977-08-22 | @ ATL | 122 | W 5-4 | 77-45 | 1 | 5,711 | Jim Lonborg | Preston Hanna | Jim Lonborg | Preston Hanna | Ron Reed | 638 | 517 | 121 |
| 1977-08-23 | @ ATL | 123 | W 3-2 | 78-45 | 1 | 5,972 | Randy Lerch | Phil Niekro | Randy Lerch | Phil Niekro | Tug McGraw | 641 | 519 | 122 |
| 1977-08-24 | @ HOU | 124 | L 1-3 | 78-46 | 1 | 13,098 | Larry Christenson | Joe Niekro | Joe Niekro | Larry Christenson | | 642 | 522 | 120 |
| 1977-08-25 | @ HOU | 125 | L 5-6 | 78-47 | 1 | 11,802 | Jim Kaat | Dan Larson | Gene Pentz | Ron Reed | Bo McLaughlin | 647 | 528 | 119 |
| 1977-08-26 | @ CIN | 126 | L 2-4 | 78-48 | 1 | 46,079 | Steve Carlton | Tom Seaver | Tom Seaver | Steve Carlton | | 649 | 532 | 117 |
| 1977-08-27 | @ CIN | 127 | L 5-6 | 78-49 | 1 | 46,139 | Jim Lonborg | Mario Soto | Jack Billingham | Tug McGraw | | 654 | 538 | 116 |
| 1977-08-28 | @ CIN | 128 | L 0-9 | 78-50 | 1 | 43,512 | Randy Lerch | Paul Moskau | Paul Moskau | Randy Lerch | | 654 | 547 | 107 |
| 1977-08-29 | vs ATL | 129 | W 3-2 | 79-50 | 1 | 36,263 | Larry Christenson | Buzz Capra | Gene Garber | Steve Hargan | | 657 | 549 | 108 |
| 1977-08-30 | vs ATL | 130 | W 11-2 | 80-50 | 1 | 32,278 | Jim Kaat | Preston Hanna | Jim Kaat | Preston Hanna | | 668 | 551 | 117 |
| 1977-08-31 | vs ATL | 131 | W 6-1 | 81-50 | 1 | 29,102 | Steve Carlton | Phil Niekro | Steve Carlton | Phil Niekro | | 674 | 552 | 122 |
| 1977-09-02 | vs CIN | 132 | W 3-0 | 82-50 | 1 | 47,732 | Jim Lonborg | Mario Soto | Jim Lonborg | Mario Soto | | 677 | 552 | 125 |
| 1977-09-03 | vs CIN | 133 | W 9-3 | 83-50 | 1 | 55,062 | Larry Christenson | Paul Moskau | Larry Christenson | Paul Moskau | | 686 | 555 | 131 |
| 1977-09-04 | vs CIN | 134 | L 2-5 | 83-51 | 1 | 40,051 | Jim Kaat | Fred Norman | Fred Norman | Jim Kaat | | 688 | 560 | 128 |
| 1977-09-05 | @ PIT | 135 | L 1-3 | 84-52 | 1 | 0 | Randy Lerch | John Candelaria | John Candelaria | Randy Lerch | Rich Gossage | 689 | 563 | 126 |
| 1977-09-05 | @ PIT | 136 | W 11-1 | 84-52 | 1 | 40,423 | Steve Carlton | Bruce Kison | Steve Carlton | Bruce Kison | | 700 | 564 | 136 |
| 1977-09-06 | @ PIT | 137 | L 4-5 | 84-53 | 1 | 15,136 | Ron Reed | Jerry Reuss | Rich Gossage | Gene Garber | | 704 | 569 | 135 |
| 1977-09-07 | @ NYN | 138 | W 6-2 | 85-53 | 1 | 7,783 | Larry Christenson | Pat Zachry | Larry Christenson | Pat Zachry | | 710 | 571 | 139 |
| 1977-09-08 | @ NYN | 139 | W 8-2 | 86-53 | 1 | 3,186 | Jim Kaat | Nino Espinosa | Gene Garber | Nino Espinosa | Tug McGraw | 718 | 573 | 145 |
| 1977-09-09 | vs SLN | 140 | W 11-4 | 87-53 | 1 | 32,168 | Steve Carlton | John Urrea | Steve Carlton | John Urrea | | 729 | 577 | 152 |
| 1977-09-10 | vs SLN | 141 | W 3-1 | 88-53 | 1 | 43,112 | Randy Lerch | Eric Rasmussen | Randy Lerch | Eric Rasmussen | | 732 | 578 | 154 |
| 1977-09-11 | vs SLN | 142 | W 6-5 | 89-53 | 1 | 49,108 | Jim Lonborg | John Denny | Warren Brusstar | John Sutton | Gene Garber | 738 | 583 | 155 |
| 1977-09-12 | vs PIT | 143 | W 6-2 | 90-53 | 1 | 42,145 | Larry Christenson | Jerry Reuss | Larry Christenson | Jerry Reuss | | 744 | 585 | 159 |
| 1977-09-13 | vs PIT | 144 | L 0-2 | 90-54 | 1 | 42,638 | Jim Kaat | Jim Rooker | Jim Rooker | Jim Kaat | Rich Gossage | 744 | 587 | 157 |
| 1977-09-14 | vs NYN | 145 | L 0-1 | 90-55 | 1 | 25,119 | Steve Carlton | Nino Espinosa | Nino Espinosa | Steve Carlton | | 744 | 588 | 156 |
| 1977-09-15 | vs NYN | 146 | W 8-2 | 91-55 | 1 | 25,314 | Randy Lerch | Craig Swan | Randy Lerch | Craig Swan | Ron Reed | 752 | 590 | 162 |
| 1977-09-16 | @ SLN | 147 | W 12-6 | 92-55 | 1 | 19,702 | Jim Lonborg | John Denny | Warren Brusstar | John Denny | Gene Garber | 764 | 596 | 168 |
| 1977-09-17 | @ SLN | 148 | W 8-4 | 93-55 | 1 | 22,574 | Larry Christenson | Tom Underwood | Larry Christenson | Tom Underwood | Ron Reed | 772 | 600 | 172 |
| 1977-09-18 | @ SLN | 149 | L 5-12 | 93-56 | 1 | 23,169 | Jim Kaat | Bob Forsch | Bob Forsch | Jim Kaat | | 777 | 612 | 165 |
| 1977-09-20 | vs CHN | 150 | W 4-2 | 94-56 | 1 | 32,103 | Steve Carlton | Bill Bonham | Steve Carlton | Bill Bonham | | 781 | 614 | 167 |
| 1977-09-21 | vs CHN | 151 | L 0-2 | 94-57 | 1 | 31,512 | Randy Lerch | Ray Burris | Ray Burris | Randy Lerch | Bruce Sutter | 781 | 616 | 165 |
| 1977-09-22 | vs CHN | 152 | L 3-5 | 94-58 | 1 | 20,709 | Jim Lonborg | Dennis Lamp | Paul Reuschel | Jim Lonborg | Bruce Sutter | 784 | 621 | 163 |
| 1977-09-23 | @ MON | 153 | W 6-1 | 95-58 | 1 | 8,400 | Larry Christenson | Steve Rogers | Larry Christenson | Steve Rogers | Gene Garber | 790 | 622 | 168 |
| 1977-09-24 | @ MON | 154 | W 1-0 | 96-58 | 1 | 23,098 | Steve Carlton | Fred Holdsworth | Steve Carlton | Fred Holdsworth | | 791 | 622 | 169 |
| 1977-09-25 | @ MON | 155 | W 8-5 | 97-58 | 1 | 19,246 | Ron Reed | Hal Dues | Warren Brusstar | Larry Landreth | Tug McGraw | 799 | 627 | 172 |
| 1977-09-26 | @ CHN | 156 | L 7-10 | 97-59 | 1 | 3,679 | Jim Lonborg | Ray Burris | Donnie Moore | Jim Kaat | Bruce Sutter | 806 | 637 | 169 |
| 1977-09-27 | @ CHN | 157 | W 15-9 | 98-59 | 1 | 4,606 | Larry Christenson | Bill Bonham | Larry Christenson | Bill Bonham | | 821 | 646 | 175 |
| 1977-09-28 | @ CHN | 158 | W 5-2 | 99-59 | 1 | 5,116 | Manny Seoane | Mike Krukow | Randy Lerch | Mike Krukow | Warren Brusstar | 826 | 648 | 178 |
| 1977-09-29 | vs MON | 159 | L 2-7 | 99-60 | 1 | 25,808 | Steve Carlton | Fred Holdsworth | Fred Holdsworth | Steve Carlton | Don Stanhouse | 828 | 655 | 173 |
| 1977-09-30 | vs MON | 160 | W 9-4 | 100-60 | 1 | 28,436 | Jim Lonborg | Stan Bahnsen | Jim Lonborg | Stan Bahnsen | Gene Garber | 837 | 659 | 178 |
| 1977-10-01 | vs MON | 161 | L 5-6 | 100-61 | 1 | 43,095 | Ron Reed | Wayne Twitchell | Joe Kerrigan | Dan Warthen | Bill Atkinson | 842 | 665 | 177 |
| 1977-10-02 | vs MON | 162 | W 5-3 | 101-61 | 1 | 25,412 | Larry Christenson | Steve Rogers | Larry Christenson | Steve Rogers | Gene Garber | 847 | 668 | 179 |