| 1977-04-07 | @ CHN | 1 | W 5-3 | 1-0 | 1 | 39,937 | Tom Seaver | Ray Burris | Tom Seaver | Ray Burris | Skip Lockwood | 5 | 3 | 2 |
| 1977-04-09 | @ CHN | 2 | W 8-6 | 2-0 | 2 | 17,848 | Jerry Koosman | Mike Krukow | Nino Espinosa | Jim Todd | | 13 | 9 | 4 |
| 1977-04-10 | @ CHN | 3 | L 2-5 | 2-1 | 3 | 14,102 | Jon Matlack | Rick Reuschel | Rick Reuschel | Jon Matlack | Bruce Sutter | 15 | 14 | 1 |
| 1977-04-12 | vs SLN | 4 | W 4-0 | 3-1 | 1 | 23,907 | Tom Seaver | Eric Rasmussen | Tom Seaver | Eric Rasmussen | | 19 | 14 | 5 |
| 1977-04-13 | vs SLN | 5 | L 3-7 | 3-2 | 3 | 8,583 | Craig Swan | John Denny | John Denny | Craig Swan | | 22 | 21 | 1 |
| 1977-04-14 | vs SLN | 6 | L 1-4 | 3-3 | 4 | 8,030 | Jerry Koosman | Bob Forsch | Bob Forsch | Jerry Koosman | John Urrea | 23 | 25 | -2 |
| 1977-04-15 | vs CHN | 7 | L 4-8 | 3-4 | 4 | 6,148 | Jon Matlack | Mike Krukow | Paul Reuschel | Skip Lockwood | | 27 | 33 | -6 |
| 1977-04-16 | vs CHN | 8 | W 4-1 | 4-4 | 5 | 11,423 | Nino Espinosa | Rick Reuschel | Nino Espinosa | Rick Reuschel | | 31 | 34 | -3 |
| 1977-04-17 | vs CHN | 9 | W 6-0 | 5-4 | 3 | 35,337 | Tom Seaver | Bill Bonham | Tom Seaver | Bill Bonham | | 37 | 34 | 3 |
| 1977-04-18 | @ SLN | 10 | L 2-3 | 5-5 | 3 | 8,855 | Craig Swan | Bob Forsch | Bob Forsch | Craig Swan | Al Hrabosky | 39 | 37 | 2 |
| 1977-04-19 | @ SLN | 11 | W 5-2 | 6-5 | 3 | 8,689 | Jerry Koosman | Pete Falcone | Jerry Koosman | Pete Falcone | Skip Lockwood | 44 | 39 | 5 |
| 1977-04-20 | @ SLN | 12 | L 2-4 | 6-6 | 3 | 11,207 | Jon Matlack | Eric Rasmussen | Eric Rasmussen | Jon Matlack | | 46 | 43 | 3 |
| 1977-04-22 | vs PIT | 13 | L 3-4 | 6-7 | 4 | 19,495 | Tom Seaver | Jerry Reuss | Kent Tekulve | Bob Myrick | | 49 | 47 | 2 |
| 1977-04-23 | vs PIT | 14 | L 5-6 | 6-8 | 5 | 9,040 | Nino Espinosa | Bruce Kison | Rich Gossage | Ray Sadecki | | 54 | 53 | 1 |
| 1977-04-27 | vs MON | 15 | L 2-3 | 6-9 | 5 | 7,441 | Jerry Koosman | Steve Rogers | Steve Rogers | Jerry Koosman | | 56 | 56 | 0 |
| 1977-04-29 | @ SDN | 16 | W 9-2 | 7-9 | 5 | 43,497 | Jon Matlack | Rick Sawyer | Jon Matlack | Rick Sawyer | | 65 | 58 | 7 |
| 1977-04-30 | @ SDN | 17 | W 4-1 | 8-9 | 4 | 22,428 | Tom Seaver | Randy Jones | Tom Seaver | Randy Jones | | 69 | 59 | 10 |
| 1977-05-01 | @ SDN | 18 | W 8-2 | 9-9 | 4 | 14,220 | Craig Swan | Bob Shirley | Craig Swan | Bob Shirley | Skip Lockwood | 77 | 61 | 16 |
| 1977-05-02 | @ LAN | 19 | L 1-3 | 9-10 | 4 | 28,017 | Jerry Koosman | Doug Rau | Doug Rau | Jerry Koosman | Charlie Hough | 78 | 64 | 14 |
| 1977-05-03 | @ LAN | 20 | L 1-4 | 9-11 | 6 | 22,762 | Nino Espinosa | Burt Hooton | Burt Hooton | Nino Espinosa | | 79 | 68 | 11 |
| 1977-05-04 | @ LAN | 21 | L 1-3 | 9-12 | 6 | 23,398 | Jon Matlack | Tommy John | Tommy John | Jon Matlack | | 80 | 71 | 9 |
| 1977-05-05 | @ LAN | 22 | L 2-7 | 9-13 | 6 | 28,600 | Tom Seaver | Rick Rhoden | Rick Rhoden | Tom Seaver | | 82 | 78 | 4 |
| 1977-05-06 | @ SFN | 23 | L 3-5 | 9-14 | 6 | 5,872 | Craig Swan | Lynn McGlothen | Lynn McGlothen | Craig Swan | | 85 | 83 | 2 |
| 1977-05-07 | @ SFN | 24 | W 6-0 | 10-14 | 6 | 5,245 | Jerry Koosman | John Montefusco | Jerry Koosman | John Montefusco | | 91 | 83 | 8 |
| 1977-05-08 | @ SFN | 25 | L 2-4 | 10-16 | 6 | 0 | Nino Espinosa | Jim Barr | Jim Barr | Nino Espinosa | Randy Moffitt | 93 | 87 | 6 |
| 1977-05-08 | @ SFN | 26 | L 0-10 | 10-16 | 6 | 15,645 | Jon Matlack | John Curtis | John Curtis | Jon Matlack | | 93 | 97 | -4 |
| 1977-05-11 | vs SDN | 27 | L 3-6 | 10-18 | 6 | 0 | Tom Seaver | Bob Shirley | Dan Spillner | Tom Seaver | Rollie Fingers | 96 | 103 | -7 |
| 1977-05-11 | vs SDN | 28 | L 3-4 | 10-18 | 6 | 7,518 | Craig Swan | Randy Jones | Randy Jones | Craig Swan | Dave Tomlin | 99 | 107 | -8 |
| 1977-05-12 | vs SDN | 29 | L 2-5 | 10-19 | 6 | 6,071 | Jerry Koosman | Tom Griffin | Tom Griffin | Jerry Koosman | Rollie Fingers | 101 | 112 | -11 |
| 1977-05-13 | vs LAN | 30 | W 3-0 | 11-19 | 6 | 19,448 | Jon Matlack | Rick Rhoden | Jon Matlack | Rick Rhoden | | 104 | 112 | -8 |
| 1977-05-14 | vs LAN | 31 | L 4-5 | 11-20 | 6 | 18,169 | Nino Espinosa | Doug Rau | Doug Rau | Nino Espinosa | Charlie Hough | 108 | 117 | -9 |
| 1977-05-15 | vs LAN | 32 | L 3-4 | 11-21 | 6 | 26,241 | Tom Seaver | Burt Hooton | Mike Garman | Bob Apodaca | | 111 | 121 | -10 |
| 1977-05-17 | vs SFN | 33 | W 8-1 | 12-21 | 6 | 8,366 | Jerry Koosman | John Montefusco | Jerry Koosman | John Montefusco | | 119 | 122 | -3 |
| 1977-05-18 | vs SFN | 34 | W 2-0 | 13-21 | 6 | 7,131 | Jon Matlack | Jim Barr | Jon Matlack | Jim Barr | | 121 | 122 | -1 |
| 1977-05-19 | vs SFN | 35 | W 4-3 | 14-21 | 6 | 8,080 | Jackson Todd | Ed Halicki | Jackson Todd | Ed Halicki | Skip Lockwood | 125 | 125 | 0 |
| 1977-05-20 | @ CIN | 36 | L 2-6 | 14-22 | 6 | 31,504 | Tom Seaver | Gary Nolan | Gary Nolan | Tom Seaver | Woodie Fryman | 127 | 131 | -4 |
| 1977-05-21 | @ CIN | 37 | L 7-8 | 14-23 | 6 | 34,406 | Craig Swan | Pat Zachry | Dale Murray | Bob Apodaca | Rawly Eastwick | 134 | 139 | -5 |
| 1977-05-22 | @ CIN | 38 | L 1-8 | 15-24 | 6 | 0 | Jerry Koosman | Jack Billingham | Jack Billingham | Jerry Koosman | | 135 | 147 | -12 |
| 1977-05-22 | @ CIN | 39 | W 4-3 | 15-24 | 6 | 38,419 | Nino Espinosa | Fred Norman | Jackson Todd | Pedro Borbon | | 139 | 150 | -11 |
| 1977-05-24 | @ PIT | 40 | L 2-5 | 15-25 | 6 | 9,309 | Jon Matlack | Jerry Reuss | Jerry Reuss | Jon Matlack | Terry Forster | 141 | 155 | -14 |
| 1977-05-27 | @ PHI | 41 | L 4-5 | 15-26 | 5 | 28,365 | Tom Seaver | Larry Christenson | Gene Garber | Skip Lockwood | | 145 | 160 | -15 |
| 1977-05-28 | @ PHI | 42 | L 2-4 | 15-27 | 5 | 31,234 | Jerry Koosman | Jim Lonborg | Ron Reed | Skip Lockwood | | 147 | 164 | -17 |
| 1977-05-29 | @ PHI | 43 | L 6-7 | 15-28 | 6 | 43,279 | Jon Matlack | Jim Kaat | Jim Kaat | Jon Matlack | Gene Garber | 153 | 171 | -18 |
| 1977-05-30 | vs MON | 44 | L 1-5 | 15-30 | 6 | 0 | Nino Espinosa | Steve Rogers | Steve Rogers | Nino Espinosa | | 154 | 176 | -22 |
| 1977-05-30 | vs MON | 45 | L 2-3 | 15-30 | 6 | 41,033 | Jackson Todd | Stan Bahnsen | Stan Bahnsen | Jackson Todd | Bill Atkinson | 156 | 179 | -23 |
| 1977-05-31 | vs MON | 46 | W 6-2 | 16-30 | 6 | 6,505 | Craig Swan | Santo Alcala | Craig Swan | Santo Alcala | Bob Apodaca | 162 | 181 | -19 |
| 1977-06-01 | @ MON | 47 | W 6-4 | 17-30 | 6 | 13,397 | Tom Seaver | Jackie Brown | Tom Seaver | Jackie Brown | Skip Lockwood | 168 | 185 | -17 |
| 1977-06-02 | @ MON | 48 | W 7-4 | 18-30 | 5 | 11,090 | Jerry Koosman | Dan Warthen | Jerry Koosman | Dan Warthen | Skip Lockwood | 175 | 189 | -14 |
| 1977-06-03 | vs PHI | 49 | L 0-1 | 18-31 | 6 | 20,013 | Jon Matlack | Jim Lonborg | Jim Lonborg | Jon Matlack | Ron Reed | 175 | 190 | -15 |
| 1977-06-04 | vs PHI | 50 | W 2-0 | 19-31 | 6 | 16,460 | Nino Espinosa | Steve Carlton | Nino Espinosa | Steve Carlton | Skip Lockwood | 177 | 190 | -13 |
| 1977-06-05 | vs PHI | 51 | W 6-5 | 21-31 | 6 | 0 | Jackson Todd | Randy Lerch | Bob Apodaca | Tom Underwood | | 183 | 195 | -12 |
| 1977-06-05 | vs PHI | 52 | W 3-2 | 21-31 | 6 | 30,867 | Craig Swan | Jim Kaat | Craig Swan | Jim Kaat | Skip Lockwood | 186 | 197 | -11 |
| 1977-06-07 | vs CIN | 53 | W 8-0 | 22-31 | 6 | 16,067 | Tom Seaver | Pat Zachry | Tom Seaver | Pat Zachry | | 194 | 197 | -3 |
| 1977-06-08 | vs CIN | 54 | L 0-5 | 22-32 | 6 | 19,681 | Jerry Koosman | Jack Billingham | Jack Billingham | Jerry Koosman | | 194 | 202 | -8 |
| 1977-06-10 | @ HOU | 55 | L 1-4 | 22-33 | 6 | 10,623 | Jon Matlack | Joaquin Andujar | Joaquin Andujar | Jon Matlack | | 195 | 206 | -11 |
| 1977-06-11 | @ HOU | 56 | L 1-4 | 23-34 | 6 | 0 | Craig Swan | J.R. Richard | J.R. Richard | Craig Swan | | 196 | 210 | -14 |
| 1977-06-11 | @ HOU | 57 | W 6-4 | 23-34 | 6 | 27,945 | Nino Espinosa | Bo McLaughlin | Skip Lockwood | Ken Forsch | | 202 | 214 | -12 |
| 1977-06-12 | @ HOU | 58 | W 3-1 | 24-34 | 6 | 10,439 | Tom Seaver | Floyd Bannister | Tom Seaver | Floyd Bannister | | 205 | 215 | -10 |
| 1977-06-13 | @ ATL | 59 | W 7-1 | 25-34 | 6 | 8,950 | Jerry Koosman | Phil Niekro | Jerry Koosman | Phil Niekro | | 212 | 216 | -4 |
| 1977-06-14 | @ ATL | 60 | L 5-8 | 25-35 | 6 | 21,954 | Jackson Todd | Max Leon | Max Leon | Jackson Todd | Don Collins | 217 | 224 | -7 |
| 1977-06-15 | @ ATL | 61 | W 6-5 | 26-35 | 6 | 6,343 | Jon Matlack | Joey McLaughlin | Bob Apodaca | Buzz Capra | Skip Lockwood | 223 | 229 | -6 |
| 1977-06-16 | vs HOU | 62 | W 4-3 | 27-35 | 5 | 8,915 | Nino Espinosa | Ken Forsch | Nino Espinosa | Joe Sambito | Skip Lockwood | 227 | 232 | -5 |
| 1977-06-17 | vs HOU | 63 | L 1-7 | 27-36 | 5 | 15,201 | Pat Zachry | Floyd Bannister | Floyd Bannister | Pat Zachry | | 228 | 239 | -11 |
| 1977-06-18 | vs HOU | 64 | L 3-4 | 27-37 | 5 | 52,784 | Jerry Koosman | Mark Lemongello | Gene Pentz | Jerry Koosman | Joe Niekro | 231 | 243 | -12 |
| 1977-06-19 | vs HOU | 65 | W 8-2 | 28-37 | 5 | 22,342 | Craig Swan | Joaquin Andujar | Craig Swan | Joaquin Andujar | | 239 | 245 | -6 |
| 1977-06-21 | vs ATL | 66 | W 5-2 | 29-37 | 5 | 10,613 | Jon Matlack | Andy Messersmith | Rick Baldwin | Don Collins | | 244 | 247 | -3 |
| 1977-06-22 | vs ATL | 67 | L 1-4 | 29-38 | 5 | 12,087 | Nino Espinosa | Phil Niekro | Phil Niekro | Nino Espinosa | | 245 | 251 | -6 |
| 1977-06-24 | @ CHN | 68 | L 0-5 | 29-39 | 5 | 26,624 | Jerry Koosman | Rick Reuschel | Rick Reuschel | Jerry Koosman | Guillermo Hernandez | 245 | 256 | -11 |
| 1977-06-25 | @ CHN | 69 | L 4-5 | 29-40 | 5 | 33,130 | Pat Zachry | Ray Burris | Ray Burris | Bob Apodaca | | 249 | 261 | -12 |
| 1977-06-26 | @ CHN | 70 | L 2-5 | 29-41 | 5 | 36,698 | Jon Matlack | Mike Krukow | Mike Krukow | Jon Matlack | Bruce Sutter | 251 | 266 | -15 |
| 1977-06-27 | vs PHI | 71 | L 2-4 | 29-42 | 5 | 17,800 | Nino Espinosa | Randy Lerch | Tug McGraw | Skip Lockwood | | 253 | 270 | -17 |
| 1977-06-28 | vs PHI | 72 | L 1-3 | 29-43 | 5 | 13,913 | Craig Swan | Larry Christenson | Ron Reed | Rick Baldwin | Tug McGraw | 254 | 273 | -19 |
| 1977-06-29 | vs PHI | 73 | W 5-3 | 30-43 | 5 | 12,434 | Jerry Koosman | Jim Lonborg | Jerry Koosman | Jim Lonborg | Skip Lockwood | 259 | 276 | -17 |
| 1977-06-30 | @ MON | 74 | W 4-3 | 31-43 | 5 | 11,289 | Pat Zachry | Steve Rogers | Bob Apodaca | Steve Rogers | Skip Lockwood | 263 | 279 | -16 |
| 1977-07-01 | @ MON | 75 | L 5-6 | 31-45 | 6 | 0 | Jon Matlack | Stan Bahnsen | Stan Bahnsen | Jon Matlack | Joe Kerrigan | 268 | 285 | -17 |
| 1977-07-01 | @ MON | 76 | L 3-5 | 31-45 | 6 | 33,422 | Jackson Todd | Don Stanhouse | Don Stanhouse | Jackson Todd | Bill Atkinson | 271 | 290 | -19 |
| 1977-07-02 | @ MON | 77 | L 3-4 | 31-46 | 6 | 16,296 | Nino Espinosa | Santo Alcala | Santo Alcala | Nino Espinosa | Will McEnaney | 274 | 294 | -20 |
| 1977-07-03 | @ MON | 78 | L 2-4 | 31-47 | 6 | 23,499 | Craig Swan | Wayne Twitchell | Tom Walker | Craig Swan | | 276 | 298 | -22 |
| 1977-07-04 | @ PHI | 79 | L 1-3 | 31-48 | 6 | 63,283 | Jerry Koosman | Jim Lonborg | Jim Lonborg | Jerry Koosman | Ron Reed | 277 | 301 | -24 |
| 1977-07-05 | @ PHI | 80 | L 1-12 | 31-49 | 6 | 23,344 | Pat Zachry | Steve Carlton | Steve Carlton | Pat Zachry | | 278 | 313 | -35 |
| 1977-07-06 | @ PHI | 81 | L 3-5 | 31-50 | 6 | 23,185 | Jon Matlack | Jim Kaat | Gene Garber | Jon Matlack | Tug McGraw | 281 | 318 | -37 |
| 1977-07-07 | @ PHI | 82 | L 4-6 | 31-51 | 6 | 27,492 | Nino Espinosa | Randy Lerch | Warren Brusstar | Nino Espinosa | Ron Reed | 285 | 324 | -39 |
| 1977-07-08 | vs MON | 83 | L 4-5 | 31-52 | 6 | 10,770 | Jerry Koosman | Wayne Twitchell | Wayne Twitchell | Jerry Koosman | Bill Atkinson | 289 | 329 | -40 |
| 1977-07-09 | vs MON | 84 | W 7-5 | 32-52 | 6 | 10,407 | Craig Swan | Steve Rogers | Paul Siebert | Will McEnaney | | 296 | 334 | -38 |
| 1977-07-10 | vs MON | 85 | W 2-1 | 33-52 | 6 | 14,503 | Pat Zachry | Jackie Brown | Pat Zachry | Jackie Brown | Skip Lockwood | 298 | 335 | -37 |
| 1977-07-12 | vs CHN | 86 | W 4-2 | 34-52 | 6 | 8,093 | Jon Matlack | Rick Reuschel | Jon Matlack | Rick Reuschel | Skip Lockwood | 302 | 337 | -35 |
| 1977-07-13 | vs CHN | 87 | L 2-5 | 34-53 | 6 | 14,626 | Jerry Koosman | Ray Burris | Ray Burris | Jerry Koosman | | 304 | 342 | -38 |
| 1977-07-15 | vs PIT | 88 | L 1-7 | 35-54 | 6 | 0 | Pat Zachry | Jim Rooker | Jim Rooker | Pat Zachry | | 305 | 349 | -44 |
| 1977-07-15 | vs PIT | 89 | W 6-1 | 35-54 | 6 | 20,219 | Nino Espinosa | Jerry Reuss | Nino Espinosa | Jerry Reuss | | 311 | 350 | -39 |
| 1977-07-16 | vs PIT | 90 | W 5-3 | 36-54 | 6 | 24,445 | Craig Swan | Bruce Kison | Craig Swan | Rich Gossage | Bob Apodaca | 316 | 353 | -37 |
| 1977-07-17 | vs PIT | 91 | L 1-3 | 37-55 | 6 | 0 | Jon Matlack | John Candelaria | John Candelaria | Jon Matlack | Rich Gossage | 317 | 356 | -39 |
| 1977-07-17 | vs PIT | 92 | W 9-3 | 37-55 | 6 | 19,492 | Jerry Koosman | Terry Forster | Jerry Koosman | Terry Forster | | 326 | 359 | -33 |
| 1977-07-21 | @ SDN | 93 | L 2-3 | 37-56 | 6 | 9,757 | Pat Zachry | Dave Freisleben | Rollie Fingers | Skip Lockwood | | 328 | 362 | -34 |
| 1977-07-22 | @ SDN | 94 | W 5-0 | 38-56 | 6 | 23,935 | Jon Matlack | Tom Griffin | Jon Matlack | Tom Griffin | | 333 | 362 | -29 |
| 1977-07-23 | @ SDN | 95 | L 3-4 | 38-57 | 6 | 19,656 | Jerry Koosman | John D'Acquisto | Dave Tomlin | Skip Lockwood | Rollie Fingers | 336 | 366 | -30 |
| 1977-07-24 | @ LAN | 96 | L 3-5 | 38-58 | 6 | 41,240 | Nino Espinosa | Tommy John | Charlie Hough | Bob Apodaca | | 339 | 371 | -32 |
| 1977-07-25 | @ LAN | 97 | W 1-0 | 39-58 | 6 | 30,920 | Craig Swan | Doug Rau | Craig Swan | Doug Rau | | 340 | 371 | -31 |
| 1977-07-26 | @ SFN | 98 | W 8-3 | 40-58 | 6 | 9,897 | Pat Zachry | John Montefusco | Pat Zachry | John Montefusco | Bob Apodaca | 348 | 374 | -26 |
| 1977-07-27 | @ SFN | 99 | W 7-4 | 41-58 | 6 | 4,406 | Jon Matlack | Bob Knepper | Jon Matlack | Bob Knepper | Skip Lockwood | 355 | 378 | -23 |
| 1977-07-29 | vs SDN | 100 | W 4-1 | 42-58 | 6 | 13,431 | Jerry Koosman | Bob Shirley | Jerry Koosman | Bob Shirley | Skip Lockwood | 359 | 379 | -20 |
| 1977-07-30 | vs SDN | 101 | L 6-8 | 42-59 | 6 | 20,407 | Nino Espinosa | Dave Freisleben | Dave Freisleben | Nino Espinosa | Rollie Fingers | 365 | 387 | -22 |
| 1977-07-31 | vs SDN | 102 | W 10-9 | 43-59 | 6 | 13,386 | Craig Swan | Dave Wehrmeister | Craig Swan | Dave Wehrmeister | Skip Lockwood | 375 | 396 | -21 |
| 1977-08-01 | vs LAN | 103 | W 8-7 | 44-59 | 6 | 9,062 | Pat Zachry | Don Sutton | Skip Lockwood | Mike Garman | | 383 | 403 | -20 |
| 1977-08-02 | vs LAN | 104 | L 2-7 | 44-60 | 6 | 24,145 | Jerry Koosman | Tommy John | Tommy John | Jerry Koosman | | 385 | 410 | -25 |
| 1977-08-03 | vs LAN | 105 | W 4-3 | 45-60 | 6 | 13,283 | Nino Espinosa | Doug Rau | Paul Siebert | Mike Garman | | 389 | 413 | -24 |
| 1977-08-05 | vs SFN | 106 | W 3-2 | 46-60 | 6 | 15,747 | Craig Swan | Lynn McGlothen | Bob Myrick | Gary Lavelle | | 392 | 415 | -23 |
| 1977-08-06 | vs SFN | 107 | L 3-7 | 46-61 | 6 | 13,899 | Pat Zachry | Ed Halicki | Ed Halicki | Pat Zachry | | 395 | 422 | -27 |
| 1977-08-07 | vs SFN | 108 | L 4-7 | 46-62 | 6 | 15,826 | Jon Matlack | John Montefusco | John Montefusco | Bob Apodaca | Gary Lavelle | 399 | 429 | -30 |
| 1977-08-08 | vs SLN | 109 | L 2-4 | 46-63 | 6 | 12,519 | Jerry Koosman | Eric Rasmussen | Al Hrabosky | Jerry Koosman | | 401 | 433 | -32 |
| 1977-08-09 | vs SLN | 110 | W 4-1 | 47-63 | 6 | 15,351 | Nino Espinosa | John Denny | Nino Espinosa | John Denny | | 405 | 434 | -29 |
| 1977-08-10 | vs SLN | 111 | L 1-3 | 47-64 | 6 | 16,463 | Craig Swan | Tom Underwood | Tom Underwood | Craig Swan | Butch Metzger | 406 | 437 | -31 |
| 1977-08-11 | @ PIT | 112 | L 1-9 | 47-65 | 6 | 9,260 | Pat Zachry | Odell Jones | Odell Jones | Pat Zachry | | 407 | 446 | -39 |
| 1977-08-12 | @ PIT | 113 | L 2-3 | 47-67 | 6 | 0 | Jerry Koosman | Jim Rooker | Jim Rooker | Jerry Koosman | | 409 | 449 | -40 |
| 1977-08-12 | @ PIT | 114 | L 5-6 | 47-67 | 6 | 18,994 | Bob Myrick | Bruce Kison | Larry Demery | Paul Siebert | | 414 | 455 | -41 |
| 1977-08-13 | @ PIT | 115 | L 0-2 | 47-68 | 6 | 32,212 | Jon Matlack | Jerry Reuss | Jerry Reuss | Jon Matlack | | 414 | 457 | -43 |
| 1977-08-14 | @ PIT | 116 | L 3-6 | 47-69 | 6 | 17,945 | Nino Espinosa | John Candelaria | John Candelaria | Nino Espinosa | Kent Tekulve | 417 | 463 | -46 |
| 1977-08-15 | @ SLN | 117 | W 7-4 | 48-69 | 6 | 18,818 | Craig Swan | John Denny | Craig Swan | John Denny | Bob Apodaca | 424 | 467 | -43 |
| 1977-08-16 | @ SLN | 118 | W 5-1 | 49-69 | 6 | 21,277 | Pat Zachry | Tom Underwood | Pat Zachry | Tom Underwood | | 429 | 468 | -39 |
| 1977-08-17 | @ SLN | 119 | L 0-2 | 49-70 | 6 | 16,727 | Jerry Koosman | Bob Forsch | Bob Forsch | Jerry Koosman | | 429 | 470 | -41 |
| 1977-08-19 | vs CIN | 120 | L 1-4 | 49-72 | 6 | 0 | Jon Matlack | Doug Capilla | Doug Capilla | Jon Matlack | | 430 | 474 | -44 |
| 1977-08-19 | vs CIN | 121 | L 3-4 | 49-72 | 6 | 36,771 | Nino Espinosa | Paul Moskau | Paul Moskau | Nino Espinosa | Pedro Borbon | 433 | 478 | -45 |
| 1977-08-20 | vs CIN | 122 | L 2-8 | 49-73 | 6 | 26,124 | Craig Swan | Fred Norman | Fred Norman | Craig Swan | | 435 | 486 | -51 |
| 1977-08-21 | vs CIN | 123 | L 1-5 | 49-74 | 6 | 46,265 | Jerry Koosman | Tom Seaver | Tom Seaver | Jerry Koosman | | 436 | 491 | -55 |
| 1977-08-22 | vs HOU | 124 | W 2-1 | 50-74 | 6 | 10,247 | Pat Zachry | J.R. Richard | Pat Zachry | J.R. Richard | Skip Lockwood | 438 | 492 | -54 |
| 1977-08-23 | vs HOU | 125 | W 2-1 | 51-74 | 6 | 9,071 | Nino Espinosa | Floyd Bannister | Skip Lockwood | Joe Sambito | | 440 | 493 | -53 |
| 1977-08-24 | @ CIN | 126 | L 4-11 | 51-75 | 6 | 28,832 | Jon Matlack | Doug Capilla | Doug Capilla | Jon Matlack | | 444 | 504 | -60 |
| 1977-08-25 | @ CIN | 127 | L 2-3 | 51-76 | 6 | 27,060 | Bob Myrick | Fred Norman | Fred Norman | Bob Apodaca | Pedro Borbon | 446 | 507 | -61 |
| 1977-08-26 | @ ATL | 128 | L 3-5 | 51-77 | 6 | 18,001 | Jerry Koosman | Preston Hanna | Preston Hanna | Jerry Koosman | Mike Davey | 449 | 512 | -63 |
| 1977-08-27 | @ ATL | 129 | L 4-5 | 51-78 | 6 | 8,328 | Pat Zachry | Phil Niekro | Phil Niekro | Skip Lockwood | | 453 | 517 | -64 |
| 1977-08-28 | @ ATL | 130 | L 4-6 | 51-79 | 6 | 6,199 | Nino Espinosa | Eddie Solomon | Eddie Solomon | Nino Espinosa | Dave Campbell | 457 | 523 | -66 |
| 1977-08-30 | @ HOU | 131 | L 2-6 | 51-80 | 6 | 6,731 | Bob Myrick | Joe Niekro | Joe Niekro | Bob Myrick | | 459 | 529 | -70 |
| 1977-08-31 | @ HOU | 132 | L 2-5 | 51-81 | 6 | 6,527 | Jerry Koosman | Mark Lemongello | Mark Lemongello | Jerry Koosman | | 461 | 534 | -73 |
| 1977-09-02 | vs ATL | 133 | W 4-0 | 52-82 | 6 | 0 | Pat Zachry | Eddie Solomon | Pat Zachry | Eddie Solomon | | 465 | 534 | -69 |
| 1977-09-02 | vs ATL | 134 | L 2-3 | 52-82 | 6 | 10,080 | Jackson Todd | Buzz Capra | Buzz Capra | Jackson Todd | Dave Campbell | 467 | 537 | -70 |
| 1977-09-03 | vs ATL | 135 | W 9-1 | 53-82 | 6 | 15,460 | Nino Espinosa | Preston Hanna | Nino Espinosa | Preston Hanna | | 476 | 538 | -62 |
| 1977-09-04 | vs ATL | 136 | L 5-7 | 53-83 | 6 | 9,435 | Bob Myrick | Phil Niekro | Phil Niekro | Rick Baldwin | Dave Campbell | 481 | 545 | -64 |
| 1977-09-05 | vs MON | 137 | L 3-4 | 53-84 | 6 | 6,583 | Jerry Koosman | Wayne Twitchell | Wayne Twitchell | Jerry Koosman | Don Stanhouse | 484 | 549 | -65 |
| 1977-09-06 | vs MON | 138 | W 5-3 | 54-84 | 6 | 4,702 | Jackson Todd | Fred Holdsworth | Jackson Todd | Fred Holdsworth | Bob Apodaca | 489 | 552 | -63 |
| 1977-09-07 | vs PHI | 139 | L 2-6 | 54-85 | 6 | 7,783 | Pat Zachry | Larry Christenson | Larry Christenson | Pat Zachry | | 491 | 558 | -67 |
| 1977-09-08 | vs PHI | 140 | L 2-8 | 54-86 | 6 | 3,186 | Nino Espinosa | Jim Kaat | Gene Garber | Nino Espinosa | Tug McGraw | 493 | 566 | -73 |
| 1977-09-09 | @ CHN | 141 | L 8-10 | 54-87 | 6 | 3,983 | Craig Swan | Mike Krukow | Bruce Sutter | Bob Apodaca | | 501 | 576 | -75 |
| 1977-09-10 | @ CHN | 142 | W 7-2 | 55-87 | 6 | 16,256 | Jerry Koosman | Bill Bonham | Skip Lockwood | Donnie Moore | | 508 | 578 | -70 |
| 1977-09-11 | @ CHN | 143 | W 7-3 | 56-87 | 6 | 21,404 | Jackson Todd | Rick Reuschel | Bob Myrick | Rick Reuschel | Skip Lockwood | 515 | 581 | -66 |
| 1977-09-12 | @ MON | 144 | W 4-3 | 57-87 | 6 | 8,927 | Pat Zachry | Stan Bahnsen | Pat Zachry | Stan Bahnsen | Skip Lockwood | 519 | 584 | -65 |
| 1977-09-13 | @ MON | 145 | L 5-8 | 57-88 | 6 | 7,675 | Roy Lee Jackson | Steve Rogers | Steve Rogers | Bob Apodaca | | 524 | 592 | -68 |
| 1977-09-14 | @ PHI | 146 | W 1-0 | 58-88 | 6 | 25,119 | Nino Espinosa | Steve Carlton | Nino Espinosa | Steve Carlton | | 525 | 592 | -67 |
| 1977-09-15 | @ PHI | 147 | L 2-8 | 58-89 | 6 | 25,314 | Craig Swan | Randy Lerch | Randy Lerch | Craig Swan | Ron Reed | 527 | 600 | -73 |
| 1977-09-17 | vs CHN | 148 | W 5-4 | 59-90 | 6 | 0 | Pat Zachry | Dennis Lamp | Bob Apodaca | Paul Reuschel | | 532 | 604 | -72 |
| 1977-09-17 | vs CHN | 149 | L 3-4 | 59-90 | 6 | 5,963 | Roy Lee Jackson | Dave Roberts | Guillermo Hernandez | Skip Lockwood | | 535 | 608 | -73 |
| 1977-09-18 | vs CHN | 150 | L 3-6 | 60-91 | 6 | 0 | Jackson Todd | Rick Reuschel | Rick Reuschel | Jackson Todd | Bruce Sutter | 538 | 614 | -76 |
| 1977-09-18 | vs CHN | 151 | W 6-0 | 60-91 | 6 | 5,191 | Craig Swan | Mike Krukow | Craig Swan | Mike Krukow | Bob Myrick | 544 | 614 | -70 |
| 1977-09-20 | vs PIT | 152 | L 2-4 | 60-92 | 6 | 3,372 | Nino Espinosa | John Candelaria | John Candelaria | Nino Espinosa | | 546 | 618 | -72 |
| 1977-09-21 | vs PIT | 153 | L 0-4 | 60-93 | 6 | 5,044 | Jerry Koosman | Bruce Kison | Bruce Kison | Jerry Koosman | Rich Gossage | 546 | 622 | -76 |
| 1977-09-23 | vs SLN | 154 | L 6-10 | 60-94 | 6 | 4,288 | Roy Lee Jackson | Bob Forsch | Bob Forsch | Roy Lee Jackson | Rawly Eastwick | 552 | 632 | -80 |
| 1977-09-27 | @ PIT | 155 | W 7-1 | 61-94 | 6 | 3,379 | Nino Espinosa | Bruce Kison | Nino Espinosa | Bruce Kison | | 559 | 633 | -74 |
| 1977-09-28 | @ PIT | 156 | L 2-3 | 61-95 | 6 | 2,673 | Craig Swan | Jim Rooker | Jim Rooker | Craig Swan | Rich Gossage | 561 | 636 | -75 |
| 1977-09-29 | @ PIT | 157 | L 2-5 | 61-96 | 6 | 2,504 | Doc Medich | Terry Forster | Terry Forster | Doc Medich | Kent Tekulve | 563 | 641 | -78 |
| 1977-09-30 | @ SLN | 158 | L 2-7 | 62-97 | 6 | 0 | Jackson Todd | John Denny | John Denny | Jackson Todd | | 565 | 648 | -83 |
| 1977-09-30 | @ SLN | 159 | W 6-3 | 62-97 | 6 | 7,959 | Jon Matlack | Pete Falcone | Jon Matlack | Pete Falcone | Bob Myrick | 571 | 651 | -80 |
| 1977-10-01 | @ SLN | 160 | W 8-4 | 63-98 | 6 | 0 | Nino Espinosa | Eric Rasmussen | Nino Espinosa | Eric Rasmussen | | 579 | 655 | -76 |
| 1977-10-01 | @ SLN | 161 | L 2-4 | 63-98 | 6 | 5,841 | Roy Lee Jackson | Tom Underwood | Tom Underwood | Roy Lee Jackson | Al Hrabosky | 581 | 659 | -78 |
| 1977-10-02 | @ SLN | 162 | W 6-4 | 64-98 | 6 | 7,365 | Pat Zachry | Bob Forsch | Pat Zachry | Bob Forsch | Rick Baldwin | 587 | 663 | -76 |