| 1977-04-07 | @ NYA | 1 | L 0-3 | - | | 43,786 | Bill Travers | Catfish Hunter | Catfish Hunter | Bill Travers | Sparky Lyle | 0 | 3 | -3 |
| 1977-04-09 | @ NYA | 2 | W 3-2 | - | | 16,726 | Jerry Augustine | Ed Figueroa | Jerry Augustine | Ed Figueroa | Bill Castro | 3 | 5 | -2 |
| 1977-04-10 | @ NYA | 3 | W 2-1 | - | | 17,117 | Moose Haas | Don Gullett | Bob McClure | Don Gullett | Bill Castro | 5 | 6 | -1 |
| 1977-04-12 | vs BAL | 4 | L 0-1 | - | | 55,120 | Bill Travers | Jim Palmer | Jim Palmer | Bill Travers | | 5 | 7 | -2 |
| 1977-04-14 | vs BAL | 5 | W 5-0 | - | | 5,727 | Jim Slaton | Rudy May | Jim Slaton | Rudy May | | 10 | 7 | 3 |
| 1977-04-15 | vs NYA | 6 | W 7-4 | - | | 11,818 | Jerry Augustine | Don Gullett | Jerry Augustine | Don Gullett | Bob McClure | 17 | 11 | 6 |
| 1977-04-16 | vs NYA | 7 | W 4-3 | - | | 15,913 | Moose Haas | Ken Holtzman | Bill Castro | Sparky Lyle | | 21 | 14 | 7 |
| 1977-04-17 | vs NYA | 8 | W 2-0 | - | | 37,186 | Bill Travers | Dock Ellis | Bill Travers | Dock Ellis | | 23 | 14 | 9 |
| 1977-04-19 | @ OAK | 9 | W 5-4 | - | | 3,799 | Jim Slaton | Doc Medich | Bill Castro | Dave Giusti | | 28 | 18 | 10 |
| 1977-04-20 | @ OAK | 10 | L 2-4 | - | | 3,849 | Jerry Augustine | Mike Torrez | Mike Torrez | Jerry Augustine | | 30 | 22 | 8 |
| 1977-04-22 | @ CAL | 11 | L 4-7 | - | | 14,773 | Moose Haas | Wayne Simpson | Wayne Simpson | Moose Haas | Dick Drago | 34 | 29 | 5 |
| 1977-04-23 | @ CAL | 12 | W 4-1 | - | | 42,368 | Bill Travers | Paul Hartzell | Bill Travers | Paul Hartzell | Bill Castro | 38 | 30 | 8 |
| 1977-04-24 | @ CAL | 13 | W 10-9 | - | | 14,878 | Jim Slaton | Frank Tanana | Gary Beare | Mickey Scott | Bill Castro | 48 | 39 | 9 |
| 1977-04-26 | vs BOS | 14 | L 1-3 | - | | 12,676 | Jerry Augustine | Rick Wise | Rick Wise | Jerry Augustine | Bill Campbell | 49 | 42 | 7 |
| 1977-04-27 | vs BOS | 15 | W 4-2 | - | | 10,646 | Moose Haas | Reggie Cleveland | Bill Castro | Reggie Cleveland | | 53 | 44 | 9 |
| 1977-04-29 | vs CLE | 16 | W 6-5 | - | | 10,511 | Bill Travers | Pat Dobson | Bill Travers | Pat Dobson | Bob McClure | 59 | 49 | 10 |
| 1977-04-30 | vs CLE | 17 | L 0-1 | - | | 12,324 | Jim Slaton | Dennis Eckersley | Dennis Eckersley | Jim Slaton | Dave LaRoche | 59 | 50 | 9 |
| 1977-05-01 | vs CLE | 18 | W 7-3 | - | | 26,336 | Jerry Augustine | Wayne Garland | Jerry Augustine | Wayne Garland | | 66 | 53 | 13 |
| 1977-05-01 | vs CLE | 19 | L 5-8 | - | | 26,336 | Gary Beare | Jim Bibby | Al Fitzmorris | Gary Beare | Jim Kern | 71 | 61 | 10 |
| 1977-05-02 | @ TOR | 20 | W 3-1 | - | | 17,577 | Moose Haas | Steve Hargan | Moose Haas | Steve Hargan | Bill Castro | 74 | 62 | 12 |
| 1977-05-03 | @ TOR | 21 | W 6-2 | - | | 13,148 | Barry Cort | Jesse Jefferson | Barry Cort | Jesse Jefferson | | 80 | 64 | 16 |
| 1977-05-04 | @ TOR | 22 | L 3-10 | - | | 25,699 | Jim Slaton | Bill Singer | Bill Singer | Jim Slaton | Mike Willis | 83 | 74 | 9 |
| 1977-05-05 | @ TOR | 23 | L 8-9 | - | | 12,268 | Gary Beare | Jerry Garvin | Pete Vuckovich | Bill Castro | | 91 | 83 | 8 |
| 1977-05-06 | @ DET | 24 | L 2-5 | - | | 12,817 | Jerry Augustine | Dave Roberts | Dave Roberts | Jerry Augustine | Steve Foucault | 93 | 88 | 5 |
| 1977-05-07 | @ DET | 25 | L 2-6 | - | | 15,391 | Bill Travers | Dave Rozema | Dave Rozema | Bill Travers | | 95 | 94 | 1 |
| 1977-05-08 | @ DET | 26 | W 7-4 | - | | 27,783 | Moose Haas | Vern Ruhle | Moose Haas | Vern Ruhle | Bill Castro | 102 | 98 | 4 |
| 1977-05-10 | @ CLE | 27 | L 0-1 | - | | 0 | Jim Slaton | Jim Bibby | Jim Bibby | Jim Slaton | | 102 | 99 | 3 |
| 1977-05-10 | @ CLE | 28 | L 4-7 | - | | 4,259 | Gary Beare | Dennis Eckersley | Jim Kern | Gary Beare | Dave LaRoche | 106 | 106 | 0 |
| 1977-05-11 | @ CLE | 29 | L 3-4 | - | | 3,541 | Jerry Augustine | Wayne Garland | Wayne Garland | Jerry Augustine | Jim Kern | 109 | 110 | -1 |
| 1977-05-12 | vs DET | 30 | L 1-9 | - | | 6,390 | Bill Travers | Dave Rozema | Dave Rozema | Bill Travers | | 110 | 119 | -9 |
| 1977-05-13 | vs DET | 31 | W 9-3 | - | | 12,153 | Moose Haas | Vern Ruhle | Moose Haas | Vern Ruhle | | 119 | 122 | -3 |
| 1977-05-14 | vs DET | 32 | L 2-3 | - | | 12,632 | Barry Cort | Fernando Arroyo | Fernando Arroyo | Barry Cort | John Hiller | 121 | 125 | -4 |
| 1977-05-15 | vs DET | 33 | L 3-5 | - | | 0 | Jim Slaton | Bob Sykes | Steve Foucault | Jim Slaton | | 124 | 130 | -6 |
| 1977-05-15 | vs DET | 34 | W 3-2 | - | | 47,732 | Jerry Augustine | Dave Roberts | Jerry Augustine | Dave Roberts | | 127 | 132 | -5 |
| 1977-05-17 | vs TOR | 35 | L 1-3 | - | | 6,810 | Moose Haas | Jesse Jefferson | Jesse Jefferson | Moose Haas | Jerry Johnson | 128 | 135 | -7 |
| 1977-05-18 | vs TOR | 36 | W 3-2 | - | | 7,208 | Barry Cort | Dave Lemanczyk | Bill Castro | Pete Vuckovich | | 131 | 137 | -6 |
| 1977-05-19 | vs TOR | 37 | W 5-3 | - | | 8,469 | Jim Slaton | Bill Singer | Jim Slaton | Bill Singer | Bob McClure | 136 | 140 | -4 |
| 1977-05-20 | @ BOS | 38 | W 15-7 | - | | 25,991 | Jerry Augustine | Luis Tiant | Jerry Augustine | Luis Tiant | | 151 | 147 | 4 |
| 1977-05-21 | @ BOS | 39 | L 9-10 | - | | 25,405 | Moose Haas | Bob Stanley | Tom House | Bill Castro | | 160 | 157 | 3 |
| 1977-05-22 | @ BOS | 40 | L 10-14 | - | | 0 | Gary Beare | Reggie Cleveland | Bill Campbell | Rich Folkers | | 170 | 171 | -1 |
| 1977-05-22 | @ BOS | 41 | W 6-0 | - | | 29,653 | Eduardo Rodriguez | Fergie Jenkins | Eduardo Rodriguez | Fergie Jenkins | | 176 | 171 | 5 |
| 1977-05-23 | @ BAL | 42 | L 5-6 | - | | 12,009 | Jim Slaton | Mike Flanagan | Dyar Miller | Jim Slaton | | 181 | 177 | 4 |
| 1977-05-24 | @ BAL | 43 | L 1-2 | - | | 5,224 | Jerry Augustine | Jim Palmer | Jim Palmer | Jerry Augustine | | 182 | 179 | 3 |
| 1977-05-25 | vs CHA | 44 | W 7-4 | - | | 14,346 | Moose Haas | Chris Knapp | Moose Haas | Chris Knapp | | 189 | 183 | 6 |
| 1977-05-26 | vs CHA | 45 | L 3-4 | - | | 14,084 | Eduardo Rodriguez | Steve Stone | Steve Stone | Eduardo Rodriguez | Lerrin LaGrow | 192 | 187 | 5 |
| 1977-05-27 | vs TEX | 46 | W 6-5 | - | | 12,004 | Jim Slaton | Doyle Alexander | Bill Castro | Paul Lindblad | | 198 | 192 | 6 |
| 1977-05-28 | vs TEX | 47 | W 3-1 | - | | 19,413 | Jerry Augustine | Nelson Briles | Jerry Augustine | Nelson Briles | | 201 | 193 | 8 |
| 1977-05-29 | vs TEX | 48 | L 4-5 | - | | 15,281 | Bill Travers | Mike Marshall | Adrian Devine | Sam Hinds | | 205 | 198 | 7 |
| 1977-05-30 | @ CHA | 49 | W 4-3 | - | | 0 | Moose Haas | Chris Knapp | Jim Slaton | Dave Hamilton | | 209 | 201 | 8 |
| 1977-05-30 | @ CHA | 50 | L 3-8 | - | | 23,213 | Eduardo Rodriguez | Steve Stone | Steve Stone | Eduardo Rodriguez | | 212 | 209 | 3 |
| 1977-06-03 | @ TEX | 51 | L 8-15 | - | | 14,145 | Jerry Augustine | Mike Marshall | Steve Hargan | Jerry Augustine | | 220 | 224 | -4 |
| 1977-06-04 | @ TEX | 52 | W 3-2 | - | | 15,540 | Moose Haas | Bert Blyleven | Bill Castro | Bert Blyleven | | 223 | 226 | -3 |
| 1977-06-05 | @ TEX | 53 | L 6-7 | - | | 8,593 | Jim Slaton | Gaylord Perry | Gaylord Perry | Jim Slaton | Adrian Devine | 229 | 233 | -4 |
| 1977-06-06 | vs BAL | 54 | L 2-5 | - | | 7,682 | Eduardo Rodriguez | Rudy May | Rudy May | Eduardo Rodriguez | | 231 | 238 | -7 |
| 1977-06-07 | vs BAL | 55 | W 7-6 | - | | 9,190 | Lary Sorensen | Ross Grimsley | Bill Castro | Dyar Miller | | 238 | 244 | -6 |
| 1977-06-08 | vs NYA | 56 | L 2-9 | - | | 13,508 | Jerry Augustine | Mike Torrez | Mike Torrez | Jerry Augustine | | 240 | 253 | -13 |
| 1977-06-09 | vs NYA | 57 | L 1-10 | - | | 13,608 | Moose Haas | Don Gullett | Don Gullett | Moose Haas | | 241 | 263 | -22 |
| 1977-06-10 | vs KCA | 58 | W 4-3 | - | | 14,115 | Jim Slaton | Doug Bird | Jim Slaton | Larry Gura | Bill Castro | 245 | 266 | -21 |
| 1977-06-11 | vs KCA | 59 | L 0-6 | - | | 27,401 | Lary Sorensen | Dennis Leonard | Dennis Leonard | Lary Sorensen | | 245 | 272 | -27 |
| 1977-06-12 | vs KCA | 60 | W 4-0 | - | | 15,733 | Jerry Augustine | Jim Colborn | Jerry Augustine | Jim Colborn | | 249 | 272 | -23 |
| 1977-06-14 | @ BAL | 61 | L 5-8 | - | | 9,710 | Moose Haas | Jim Palmer | Dennis Martinez | Bill Castro | | 254 | 280 | -26 |
| 1977-06-15 | @ BAL | 62 | W 6-2 | - | | 7,443 | Jim Slaton | Mike Flanagan | Jim Slaton | Mike Flanagan | Sam Hinds | 260 | 282 | -22 |
| 1977-06-16 | @ BAL | 63 | L 0-6 | - | | 6,589 | Jerry Augustine | Rudy May | Rudy May | Jerry Augustine | | 260 | 288 | -28 |
| 1977-06-17 | vs CAL | 64 | L 5-7 | - | | 10,881 | Lary Sorensen | Ken Brett | Dyar Miller | Bill Castro | | 265 | 295 | -30 |
| 1977-06-18 | vs CAL | 65 | W 4-2 | - | | 47,949 | Gary Beare | Gary Nolan | Gary Beare | Gary Nolan | Bill Castro | 269 | 297 | -28 |
| 1977-06-19 | vs CAL | 66 | L 0-7 | - | | 14,244 | Moose Haas | Frank Tanana | Frank Tanana | Moose Haas | | 269 | 304 | -35 |
| 1977-06-21 | vs OAK | 67 | W 12-1 | - | | 9,619 | Jim Slaton | Paul Mitchell | Jim Slaton | Paul Mitchell | | 281 | 305 | -24 |
| 1977-06-22 | vs OAK | 68 | W 5-1 | - | | 16,759 | Jerry Augustine | Vida Blue | Jerry Augustine | Vida Blue | | 286 | 306 | -20 |
| 1977-06-24 | vs SEA | 69 | W 7-1 | - | | 11,625 | Lary Sorensen | John Montague | Lary Sorensen | John Montague | | 293 | 307 | -14 |
| 1977-06-25 | vs SEA | 70 | L 3-8 | - | | 19,572 | Moose Haas | Gary Wheelock | Gary Wheelock | Moose Haas | Enrique Romo | 296 | 315 | -19 |
| 1977-06-26 | vs SEA | 71 | W 8-6 | - | | 19,699 | Jim Slaton | Glenn Abbott | Mike Caldwell | Enrique Romo | | 304 | 321 | -17 |
| 1977-06-27 | @ MIN | 72 | L 3-10 | - | | 10,534 | Jerry Augustine | Dave Goltz | Dave Goltz | Jerry Augustine | | 307 | 331 | -24 |
| 1977-06-28 | @ MIN | 73 | L 3-8 | - | | 14,703 | Gary Beare | Paul Thormodsgard | Paul Thormodsgard | Gary Beare | | 310 | 339 | -29 |
| 1977-06-29 | @ MIN | 74 | W 1-0 | - | | 13,713 | Lary Sorensen | Dave Johnson | Lary Sorensen | Dave Johnson | Bill Castro | 311 | 339 | -28 |
| 1977-07-01 | @ SEA | 75 | W 2-1 | - | | 16,119 | Moose Haas | Gary Wheelock | Moose Haas | Gary Wheelock | | 313 | 340 | -27 |
| 1977-07-02 | @ SEA | 76 | L 1-2 | - | | 24,466 | Jim Slaton | Glenn Abbott | Glenn Abbott | Jim Slaton | Mike Kekich | 314 | 342 | -28 |
| 1977-07-03 | @ SEA | 77 | W 10-3 | - | | 16,226 | Jerry Augustine | Dick Pole | Jerry Augustine | Dick Pole | | 324 | 345 | -21 |
| 1977-07-04 | vs MIN | 78 | L 0-5 | - | | 13,070 | Lary Sorensen | Paul Thormodsgard | Paul Thormodsgard | Lary Sorensen | | 324 | 350 | -26 |
| 1977-07-05 | vs MIN | 79 | L 2-3 | - | | 10,625 | Mike Caldwell | Dave Goltz | Dave Goltz | Mike Caldwell | | 326 | 353 | -27 |
| 1977-07-06 | @ KCA | 80 | L 7-8 | - | | 22,804 | Moose Haas | Andy Hassler | Marty Pattin | Bill Castro | | 333 | 361 | -28 |
| 1977-07-08 | vs BOS | 81 | L 3-7 | - | | 31,663 | Jim Slaton | Reggie Cleveland | Reggie Cleveland | Jim Slaton | | 336 | 368 | -32 |
| 1977-07-09 | vs BOS | 82 | W 3-2 | - | | 25,372 | Jerry Augustine | Fergie Jenkins | Jerry Augustine | Fergie Jenkins | Bill Castro | 339 | 370 | -31 |
| 1977-07-10 | vs BOS | 83 | L 5-8 | - | | 0 | Lary Sorensen | Luis Tiant | Bill Campbell | Eduardo Rodriguez | | 344 | 378 | -34 |
| 1977-07-10 | vs BOS | 84 | L 3-7 | - | | 28,887 | Mike Caldwell | Rick Wise | Rick Wise | Mike Caldwell | | 347 | 385 | -38 |
| 1977-07-12 | vs NYA | 85 | L 2-5 | - | | 18,987 | Moose Haas | Don Gullett | Don Gullett | Moose Haas | Dick Tidrow | 349 | 390 | -41 |
| 1977-07-13 | vs NYA | 86 | W 9-8 | - | | 18,298 | Jim Slaton | Catfish Hunter | Jim Slaton | Catfish Hunter | Bill Castro | 358 | 398 | -40 |
| 1977-07-14 | vs NYA | 87 | L 3-6 | - | | 22,897 | Jerry Augustine | Ed Figueroa | Ed Figueroa | Jerry Augustine | Sparky Lyle | 361 | 404 | -43 |
| 1977-07-15 | vs BAL | 88 | L 2-4 | - | | 13,185 | Mike Caldwell | Mike Flanagan | Mike Flanagan | Mike Caldwell | | 363 | 408 | -45 |
| 1977-07-16 | vs BAL | 89 | L 0-5 | - | | 21,301 | Lary Sorensen | Rudy May | Rudy May | Lary Sorensen | | 363 | 413 | -50 |
| 1977-07-17 | vs BAL | 90 | W 3-2 | - | | 16,231 | Moose Haas | Dennis Martinez | Moose Haas | Dennis Martinez | Bill Castro | 366 | 415 | -49 |
| 1977-07-21 | @ NYA | 91 | L 0-7 | - | | 22,812 | Jim Slaton | Catfish Hunter | Catfish Hunter | Jim Slaton | | 366 | 422 | -56 |
| 1977-07-21 | @ NYA | 92 | W 5-4 | - | | 22,812 | Jerry Augustine | Ed Figueroa | Bill Castro | Dick Tidrow | | 371 | 426 | -55 |
| 1977-07-22 | @ NYA | 93 | W 6-3 | - | | 23,145 | Mike Caldwell | Mike Torrez | Mike Caldwell | Mike Torrez | | 377 | 429 | -52 |
| 1977-07-23 | @ NYA | 94 | L 1-3 | - | | 38,492 | Bill Travers | Ron Guidry | Ron Guidry | Bill Travers | | 378 | 432 | -54 |
| 1977-07-24 | @ BAL | 95 | L 2-3 | - | | 19,411 | Moose Haas | Mike Flanagan | Mike Flanagan | Moose Haas | | 380 | 435 | -55 |
| 1977-07-24 | @ BAL | 96 | L 3-4 | - | | 19,411 | Jerry Augustine | Rudy May | Dick Drago | Jerry Augustine | | 383 | 439 | -56 |
| 1977-07-25 | @ BAL | 97 | L 3-4 | - | | 8,219 | Jim Slaton | Dennis Martinez | Tippy Martinez | Sam Hinds | | 386 | 443 | -57 |
| 1977-07-26 | @ BOS | 98 | L 3-4 | - | | 30,950 | Lary Sorensen | Don Aase | Don Aase | Lary Sorensen | | 389 | 447 | -58 |
| 1977-07-27 | @ BOS | 99 | W 14-5 | - | | 31,417 | Mike Caldwell | Rick Wise | Bob McClure | Bob Stanley | | 403 | 452 | -49 |
| 1977-07-28 | @ BOS | 100 | L 0-12 | - | | 34,705 | Sam Hinds | Mike Paxton | Mike Paxton | Sam Hinds | | 403 | 464 | -61 |
| 1977-07-29 | @ TOR | 101 | W 7-3 | - | | 14,303 | Moose Haas | Jesse Jefferson | Moose Haas | Jesse Jefferson | | 410 | 467 | -57 |
| 1977-07-30 | @ TOR | 102 | W 3-2 | - | | 18,639 | Jim Slaton | Jeff Byrd | Jim Slaton | Jeff Byrd | | 413 | 469 | -56 |
| 1977-07-31 | @ TOR | 103 | L 1-4 | - | | 28,110 | Jerry Augustine | Dave Lemanczyk | Dave Lemanczyk | Jerry Augustine | Tom Murphy | 414 | 473 | -59 |
| 1977-08-01 | @ TOR | 104 | L 2-3 | - | | 17,590 | Lary Sorensen | Jim Clancy | Jim Clancy | Lary Sorensen | | 416 | 476 | -60 |
| 1977-08-02 | vs CLE | 105 | L 2-9 | - | | 0 | Mike Caldwell | Dennis Eckersley | Dennis Eckersley | Mike Caldwell | | 418 | 485 | -67 |
| 1977-08-02 | vs CLE | 106 | L 4-7 | - | | 12,658 | Bill Travers | Wayne Garland | Wayne Garland | Bill Castro | | 422 | 492 | -70 |
| 1977-08-03 | vs CLE | 107 | W 7-4 | - | | 8,570 | Moose Haas | Jim Bibby | Eduardo Rodriguez | Pat Dobson | | 429 | 496 | -67 |
| 1977-08-05 | vs TOR | 108 | L 1-6 | - | | 13,609 | Jim Slaton | Jeff Byrd | Jeff Byrd | Jim Slaton | | 430 | 502 | -72 |
| 1977-08-06 | vs TOR | 109 | L 3-5 | - | | 12,720 | Jerry Augustine | Dave Lemanczyk | Dave Lemanczyk | Jerry Augustine | Jerry Johnson | 433 | 507 | -74 |
| 1977-08-07 | vs TOR | 110 | W 6-2 | - | | 0 | Lary Sorensen | Jerry Garvin | Lary Sorensen | Jerry Garvin | Bob McClure | 439 | 509 | -70 |
| 1977-08-07 | vs TOR | 111 | W 7-5 | - | | 12,070 | Moose Haas | Jim Clancy | Moose Haas | Jim Clancy | Sam Hinds | 446 | 514 | -68 |
| 1977-08-08 | @ DET | 112 | L 1-6 | - | | 11,973 | Mike Caldwell | Jim Crawford | Jim Crawford | Mike Caldwell | | 447 | 520 | -73 |
| 1977-08-09 | @ DET | 113 | L 2-4 | - | | 0 | Jim Slaton | Dave Rozema | Dave Rozema | Jim Slaton | | 449 | 524 | -75 |
| 1977-08-09 | @ DET | 114 | W 6-4 | - | | 18,099 | Bill Travers | Bob Sykes | Bill Travers | Steve Grilli | Bob McClure | 455 | 528 | -73 |
| 1977-08-10 | @ DET | 115 | L 3-5 | - | | 11,696 | Jerry Augustine | Jack Morris | Jack Morris | Jerry Augustine | Steve Foucault | 458 | 533 | -75 |
| 1977-08-12 | @ CLE | 116 | L 0-2 | - | | 0 | Lary Sorensen | Dennis Eckersley | Dennis Eckersley | Lary Sorensen | | 458 | 535 | -77 |
| 1977-08-12 | @ CLE | 117 | L 4-5 | - | | 16,168 | Eduardo Rodriguez | Don Hood | Jim Kern | Bob McClure | | 462 | 540 | -78 |
| 1977-08-13 | @ CLE | 118 | W 6-1 | - | | 12,137 | Mike Caldwell | Jim Bibby | Mike Caldwell | Jim Bibby | | 468 | 541 | -73 |
| 1977-08-14 | @ CLE | 119 | L 4-12 | - | | 0 | Jim Slaton | Wayne Garland | Wayne Garland | Jim Slaton | | 472 | 553 | -81 |
| 1977-08-14 | @ CLE | 120 | L 5-14 | - | | 16,590 | Bill Travers | Al Fitzmorris | Al Fitzmorris | Bill Travers | | 477 | 567 | -90 |
| 1977-08-15 | vs TEX | 121 | W 6-5 | - | | 6,812 | Jerry Augustine | Gaylord Perry | Eduardo Rodriguez | Adrian Devine | | 483 | 572 | -89 |
| 1977-08-16 | vs TEX | 122 | L 3-11 | - | | 7,777 | Moose Haas | Doyle Alexander | Doyle Alexander | Moose Haas | | 486 | 583 | -97 |
| 1977-08-17 | vs BOS | 123 | W 5-3 | - | | 13,692 | Lary Sorensen | Rick Wise | Lary Sorensen | Rick Wise | | 491 | 586 | -95 |
| 1977-08-18 | vs BOS | 124 | L 4-8 | - | | 15,862 | Mike Caldwell | Fergie Jenkins | Fergie Jenkins | Mike Caldwell | | 495 | 594 | -99 |
| 1977-08-19 | vs CHA | 125 | L 1-3 | - | | 28,402 | Jim Slaton | Wilbur Wood | Wilbur Wood | Jim Slaton | | 496 | 597 | -101 |
| 1977-08-20 | vs CHA | 126 | W 4-2 | - | | 28,045 | Jerry Augustine | Steve Stone | Jerry Augustine | Steve Stone | Eduardo Rodriguez | 500 | 599 | -99 |
| 1977-08-21 | vs CHA | 127 | W 7-1 | - | | 0 | Moose Haas | Ken Kravec | Moose Haas | Ken Kravec | | 507 | 600 | -93 |
| 1977-08-21 | vs CHA | 128 | L 3-6 | - | | 27,969 | Bill Travers | Steve Renko | Steve Renko | Bill Travers | Lerrin LaGrow | 510 | 606 | -96 |
| 1977-08-22 | @ TEX | 129 | L 7-8 | - | | 7,854 | Lary Sorensen | Bert Blyleven | Adrian Devine | Eduardo Rodriguez | | 517 | 614 | -97 |
| 1977-08-23 | @ TEX | 130 | W 4-2 | - | | 12,339 | Mike Caldwell | Dock Ellis | Mike Caldwell | Dock Ellis | Bill Castro | 521 | 616 | -95 |
| 1977-08-24 | vs KCA | 131 | L 3-4 | - | | 9,082 | Jim Slaton | Marty Pattin | Doug Bird | Lary Sorensen | Steve Mingori | 524 | 620 | -96 |
| 1977-08-25 | vs KCA | 132 | L 6-9 | - | | 8,225 | Jerry Augustine | Paul Splittorff | Paul Splittorff | Jerry Augustine | Doug Bird | 530 | 629 | -99 |
| 1977-08-26 | @ CHA | 133 | L 2-4 | - | | 28,221 | Moose Haas | Steve Renko | Steve Renko | Moose Haas | Silvio Martinez | 532 | 633 | -101 |
| 1977-08-27 | @ CHA | 134 | L 6-7 | - | | 38,376 | Bill Travers | Francisco Barrios | Lerrin LaGrow | Eduardo Rodriguez | | 538 | 640 | -102 |
| 1977-08-28 | @ CHA | 135 | W 10-1 | - | | 33,027 | Lary Sorensen | Wilbur Wood | Lary Sorensen | Wilbur Wood | | 548 | 641 | -93 |
| 1977-08-30 | vs DET | 136 | L 2-4 | - | | 7,349 | Mike Caldwell | Dave Rozema | Dave Rozema | Mike Caldwell | | 550 | 645 | -95 |
| 1977-08-31 | vs DET | 137 | L 2-5 | - | | 5,945 | Jim Slaton | Milt Wilcox | Milt Wilcox | Jim Slaton | | 552 | 650 | -98 |
| 1977-09-01 | vs DET | 138 | W 1-0 | - | | 3,985 | Jerry Augustine | Fernando Arroyo | Jerry Augustine | Fernando Arroyo | Eduardo Rodriguez | 553 | 650 | -97 |
| 1977-09-02 | @ KCA | 139 | L 1-3 | - | | 0 | Moose Haas | Andy Hassler | Andy Hassler | Moose Haas | Doug Bird | 554 | 653 | -99 |
| 1977-09-02 | @ KCA | 140 | L 0-3 | - | | 22,318 | Bill Travers | Paul Splittorff | Paul Splittorff | Bill Travers | | 554 | 656 | -102 |
| 1977-09-03 | @ KCA | 141 | L 2-3 | - | | 35,604 | Lary Sorensen | Dennis Leonard | Dennis Leonard | Lary Sorensen | | 556 | 659 | -103 |
| 1977-09-04 | @ KCA | 142 | L 2-6 | - | | 24,530 | Mike Caldwell | Marty Pattin | Marty Pattin | Mike Caldwell | | 558 | 665 | -107 |
| 1977-09-05 | @ CAL | 143 | W 6-5 | - | | 10,575 | Jim Slaton | Frank Tanana | Jim Slaton | Frank Tanana | Eduardo Rodriguez | 564 | 670 | -106 |
| 1977-09-07 | @ CAL | 144 | L 1-4 | - | | 10,066 | Jerry Augustine | Paul Hartzell | Paul Hartzell | Jerry Augustine | | 565 | 674 | -109 |
| 1977-09-09 | @ OAK | 145 | W 3-1 | - | | 4,743 | Moose Haas | Rick Langford | Moose Haas | Rick Langford | | 568 | 675 | -107 |
| 1977-09-10 | @ OAK | 146 | L 1-4 | - | | 1,944 | Lary Sorensen | Pablo Torrealba | Doc Medich | Lary Sorensen | | 569 | 679 | -110 |
| 1977-09-11 | @ OAK | 147 | L 3-5 | - | | 2,279 | Bill Travers | Vida Blue | Vida Blue | Bill Travers | Doug Bair | 572 | 684 | -112 |
| 1977-09-13 | @ SEA | 148 | W 6-5 | - | | 7,595 | Jim Slaton | Glenn Abbott | Gary Beare | Glenn Abbott | Bob McClure | 578 | 689 | -111 |
| 1977-09-14 | @ SEA | 149 | W 8-5 | - | | 5,718 | Jerry Augustine | John Montague | Eduardo Rodriguez | Greg Erardi | | 586 | 694 | -108 |
| 1977-09-16 | vs OAK | 150 | L 1-8 | - | | 5,238 | Moose Haas | Joe Coleman | Joe Coleman | Moose Haas | | 587 | 702 | -115 |
| 1977-09-17 | vs OAK | 151 | W 8-1 | - | | 10,718 | Lary Sorensen | Craig Mitchell | Lary Sorensen | Craig Mitchell | | 595 | 703 | -108 |
| 1977-09-18 | vs OAK | 152 | L 1-3 | - | | 5,891 | Bill Travers | Matt Keough | Matt Keough | Bill Travers | Doug Bair | 596 | 706 | -110 |
| 1977-09-20 | vs SEA | 153 | W 5-1 | - | | 3,004 | Jim Slaton | John Montague | Jim Slaton | John Montague | | 601 | 707 | -106 |
| 1977-09-21 | vs SEA | 154 | L 4-11 | - | | 3,008 | Jerry Augustine | Doc Medich | Enrique Romo | Jerry Augustine | | 605 | 718 | -113 |
| 1977-09-24 | @ MIN | 155 | L 3-4 | - | | 4,910 | Moose Haas | Dave Goltz | Dave Goltz | Moose Haas | | 608 | 722 | -114 |
| 1977-09-25 | @ MIN | 156 | W 8-6 | - | | 0 | Lary Sorensen | Paul Thormodsgard | Lary Sorensen | Paul Thormodsgard | Eduardo Rodriguez | 616 | 728 | -112 |
| 1977-09-25 | @ MIN | 157 | L 4-8 | - | | 4,928 | Bill Travers | Pete Redfern | Ron Schueler | Bill Travers | | 620 | 736 | -116 |
| 1977-09-27 | vs CAL | 158 | W 7-5 | - | | 3,142 | Jim Slaton | Paul Hartzell | Eduardo Rodriguez | Dave LaRoche | | 627 | 741 | -114 |
| 1977-09-28 | vs CAL | 159 | L 2-4 | - | | 3,176 | Jerry Augustine | John Caneira | John Caneira | Jerry Augustine | Dyar Miller | 629 | 745 | -116 |
| 1977-09-30 | vs MIN | 160 | W 7-5 | - | | 3,159 | Moose Haas | Paul Thormodsgard | Mike Caldwell | Paul Thormodsgard | | 636 | 750 | -114 |
| 1977-10-01 | vs MIN | 161 | L 1-9 | - | | 4,056 | Lary Sorensen | Pete Redfern | Pete Redfern | Lary Sorensen | Ron Schueler | 637 | 759 | -122 |
| 1977-10-02 | vs MIN | 162 | L 2-6 | - | | 4,394 | Bill Travers | Dave Goltz | Dave Goltz | Bill Travers | | 639 | 765 | -126 |