| 1977-04-07 | vs KCA | 1 | L 4-7 | 0-1 | 6 | 46,807 | Dave Roberts | Paul Splittorff | Paul Splittorff | Dave Roberts | Mark Littell | 4 | 7 | -3 |
| 1977-04-09 | vs KCA | 2 | L 2-16 | 0-2 | 7 | 9,240 | Ray Bare | Andy Hassler | Andy Hassler | Ray Bare | Dennis Leonard | 6 | 23 | -17 |
| 1977-04-10 | vs KCA | 3 | L 0-5 | 0-3 | 7 | 7,804 | Vern Ruhle | Jim Colborn | Jim Colborn | Vern Ruhle | Larry Gura | 6 | 28 | -22 |
| 1977-04-11 | @ TOR | 4 | L 3-5 | 0-4 | 7 | 29,132 | Dave Rozema | Jesse Jefferson | Steve Hargan | John Hiller | | 9 | 33 | -24 |
| 1977-04-12 | @ TOR | 5 | W 6-1 | 1-4 | 6 | 11,505 | Dave Roberts | Bill Singer | Dave Roberts | Bill Singer | | 15 | 34 | -19 |
| 1977-04-13 | @ TOR | 6 | L 6-7 | 1-5 | 6 | 12,113 | Bob Sykes | Dave Lemanczyk | Dave Lemanczyk | Fernando Arroyo | Mike Willis | 21 | 41 | -20 |
| 1977-04-14 | @ TOR | 7 | L 3-5 | 1-6 | 6 | 13,369 | Ray Bare | Jerry Garvin | Jerry Garvin | John Hiller | | 24 | 46 | -22 |
| 1977-04-15 | @ KCA | 8 | W 4-3 | 2-6 | 5 | 15,955 | Vern Ruhle | Jim Colborn | Vern Ruhle | Jim Colborn | Steve Foucault | 28 | 49 | -21 |
| 1977-04-16 | @ KCA | 9 | W 8-5 | 3-6 | 4 | 23,753 | Dave Rozema | Paul Splittorff | John Hiller | Steve Mingori | | 36 | 54 | -18 |
| 1977-04-17 | @ KCA | 10 | L 5-6 | 3-7 | 5 | 15,868 | Dave Roberts | Andy Hassler | Larry Gura | Dave Roberts | Mark Littell | 41 | 60 | -19 |
| 1977-04-18 | @ BOS | 11 | L 3-5 | 3-8 | 6 | 30,059 | Bob Sykes | Fergie Jenkins | Fergie Jenkins | Fernando Arroyo | Jim Willoughby | 44 | 65 | -21 |
| 1977-04-19 | @ BOS | 12 | L 3-11 | 3-9 | 6 | 16,941 | Ray Bare | Bob Stanley | Bob Stanley | Ray Bare | | 47 | 76 | -29 |
| 1977-04-20 | @ BOS | 13 | W 3-2 | 4-9 | 6 | 20,289 | Vern Ruhle | Luis Tiant | Vern Ruhle | Luis Tiant | John Hiller | 50 | 78 | -28 |
| 1977-04-21 | @ BOS | 14 | W 8-0 | 5-9 | 6 | 24,903 | Dave Rozema | Reggie Cleveland | Dave Rozema | Reggie Cleveland | | 58 | 78 | -20 |
| 1977-04-24 | vs BAL | 15 | L 1-3 | 6-10 | 6 | 17,115 | Dave Roberts | Jim Palmer | Jim Palmer | Dave Roberts | | 59 | 81 | -22 |
| 1977-04-24 | vs BAL | 16 | W 2-1 | 6-10 | 6 | 17,115 | Vern Ruhle | Mike Flanagan | Vern Ruhle | Mike Flanagan | John Hiller | 61 | 82 | -21 |
| 1977-04-26 | vs CHA | 17 | L 7-10 | 6-11 | 6 | 6,396 | Dave Rozema | Ken Brett | Lerrin LaGrow | Steve Foucault | | 68 | 92 | -24 |
| 1977-04-27 | vs CHA | 18 | W 10-9 | 7-11 | 6 | 5,868 | Ray Bare | Francisco Barrios | Fernando Arroyo | Bruce Dal Canton | | 78 | 101 | -23 |
| 1977-04-29 | @ MIN | 19 | W 6-5 | 8-11 | 6 | 10,240 | Vern Ruhle | Pete Redfern | Steve Foucault | Tom Johnson | John Hiller | 84 | 106 | -22 |
| 1977-04-30 | @ MIN | 20 | L 3-7 | 8-12 | 6 | 9,596 | Dave Roberts | Geoff Zahn | Geoff Zahn | Dave Roberts | | 87 | 113 | -26 |
| 1977-05-01 | @ MIN | 21 | L 5-6 | 8-13 | 6 | 8,637 | Dave Rozema | Paul Thormodsgard | Jeff Holly | John Hiller | | 92 | 119 | -27 |
| 1977-05-03 | vs TEX | 22 | L 0-13 | 8-14 | 6 | 12,272 | Vern Ruhle | Bert Blyleven | Bert Blyleven | Vern Ruhle | | 92 | 132 | -40 |
| 1977-05-06 | vs MIL | 23 | W 5-2 | 9-14 | 6 | 12,817 | Dave Roberts | Jerry Augustine | Dave Roberts | Jerry Augustine | Steve Foucault | 97 | 134 | -37 |
| 1977-05-07 | vs MIL | 24 | W 6-2 | 10-14 | 6 | 15,391 | Dave Rozema | Bill Travers | Dave Rozema | Bill Travers | | 103 | 136 | -33 |
| 1977-05-08 | vs MIL | 25 | L 4-7 | 10-15 | 6 | 27,783 | Vern Ruhle | Moose Haas | Moose Haas | Vern Ruhle | Bill Castro | 107 | 143 | -36 |
| 1977-05-10 | vs MIN | 26 | L 5-7 | 10-16 | 7 | 8,358 | Bob Sykes | Jeff Holly | Jeff Holly | Bob Sykes | Tom Burgmeier | 112 | 150 | -38 |
| 1977-05-11 | vs MIN | 27 | W 8-3 | 11-16 | 7 | 7,893 | Dave Roberts | Geoff Zahn | Dave Roberts | Geoff Zahn | | 120 | 153 | -33 |
| 1977-05-12 | @ MIL | 28 | W 9-1 | 12-16 | 6 | 6,390 | Dave Rozema | Bill Travers | Dave Rozema | Bill Travers | | 129 | 154 | -25 |
| 1977-05-13 | @ MIL | 29 | L 3-9 | 12-17 | 6 | 12,153 | Vern Ruhle | Moose Haas | Moose Haas | Vern Ruhle | | 132 | 163 | -31 |
| 1977-05-14 | @ MIL | 30 | W 3-2 | 13-17 | 5 | 12,632 | Fernando Arroyo | Barry Cort | Fernando Arroyo | Barry Cort | John Hiller | 135 | 165 | -30 |
| 1977-05-15 | @ MIL | 31 | W 5-3 | 14-18 | 5 | 0 | Bob Sykes | Jim Slaton | Steve Foucault | Jim Slaton | | 140 | 168 | -28 |
| 1977-05-15 | @ MIL | 32 | L 2-3 | 14-18 | 5 | 47,732 | Dave Roberts | Jerry Augustine | Jerry Augustine | Dave Roberts | | 142 | 171 | -29 |
| 1977-05-17 | @ TEX | 33 | L 1-3 | 14-19 | 6 | 10,826 | Dave Rozema | Doyle Alexander | Doyle Alexander | Dave Rozema | | 143 | 174 | -31 |
| 1977-05-18 | @ TEX | 34 | L 3-6 | 14-20 | 6 | 10,090 | John Hiller | Gaylord Perry | Gaylord Perry | John Hiller | | 146 | 180 | -34 |
| 1977-05-20 | @ CHA | 35 | W 7-4 | 15-20 | 5 | 17,225 | Dave Roberts | Ken Brett | Steve Foucault | Ken Brett | | 153 | 184 | -31 |
| 1977-05-21 | @ CHA | 36 | W 3-2 | 16-20 | 5 | 20,790 | Fernando Arroyo | Francisco Barrios | Fernando Arroyo | Francisco Barrios | | 156 | 186 | -30 |
| 1977-05-22 | @ CHA | 37 | W 14-3 | 17-20 | 5 | 31,030 | Dave Rozema | Wilbur Wood | Dave Rozema | Wilbur Wood | | 170 | 189 | -19 |
| 1977-05-24 | vs CAL | 38 | L 1-2 | 17-21 | 5 | 14,194 | John Hiller | Nolan Ryan | Nolan Ryan | John Hiller | | 171 | 191 | -20 |
| 1977-05-25 | vs CAL | 39 | L 0-4 | 17-22 | 5 | 13,150 | Dave Roberts | Frank Tanana | Frank Tanana | Dave Roberts | | 171 | 195 | -24 |
| 1977-05-27 | vs SEA | 40 | L 1-2 | 17-23 | 6 | 44,207 | Mark Fidrych | Glenn Abbott | Glenn Abbott | Mark Fidrych | Mike Kekich | 172 | 197 | -25 |
| 1977-05-28 | vs SEA | 41 | L 1-3 | 17-24 | 6 | 15,820 | Dave Rozema | Dick Pole | Dick Pole | Dave Rozema | Bill Laxton | 173 | 200 | -27 |
| 1977-05-29 | vs SEA | 42 | L 4-6 | 17-25 | 6 | 11,778 | Fernando Arroyo | Rick Jones | Stan Thomas | Steve Foucault | | 177 | 206 | -29 |
| 1977-05-30 | vs OAK | 43 | L 3-6 | 17-26 | 6 | 12,026 | Dave Roberts | Dock Ellis | Dock Ellis | Dave Roberts | Joe Coleman | 180 | 212 | -32 |
| 1977-05-31 | vs OAK | 44 | W 5-2 | 18-26 | 6 | 7,067 | John Hiller | Vida Blue | John Hiller | Vida Blue | Steve Foucault | 185 | 214 | -29 |
| 1977-06-01 | vs CLE | 45 | L 4-6 | 18-27 | 6 | 17,718 | Mark Fidrych | Jim Bibby | Jim Bibby | Mark Fidrych | Sid Monge | 189 | 220 | -31 |
| 1977-06-02 | vs CLE | 46 | W 4-2 | 19-27 | 6 | 7,274 | Dave Rozema | Pat Dobson | Dave Rozema | Pat Dobson | Steve Foucault | 193 | 222 | -29 |
| 1977-06-04 | @ CAL | 47 | W 9-6 | 20-27 | 6 | 30,331 | Dave Roberts | Nolan Ryan | John Hiller | Nolan Ryan | | 202 | 228 | -26 |
| 1977-06-05 | @ CAL | 48 | L 1-5 | 20-28 | 6 | 21,032 | Fernando Arroyo | Frank Tanana | Frank Tanana | Fernando Arroyo | | 203 | 233 | -30 |
| 1977-06-06 | @ CAL | 49 | W 8-0 | 21-28 | 6 | 38,551 | Mark Fidrych | Gary Ross | Mark Fidrych | Gary Ross | | 211 | 233 | -22 |
| 1977-06-07 | @ SEA | 50 | W 5-2 | 22-28 | 6 | 10,050 | Dave Rozema | Glenn Abbott | Dave Rozema | Glenn Abbott | Steve Foucault | 216 | 235 | -19 |
| 1977-06-08 | @ SEA | 51 | L 2-3 | 22-29 | 6 | 11,211 | John Hiller | Dick Pole | Mike Kekich | John Hiller | | 218 | 238 | -20 |
| 1977-06-09 | @ SEA | 52 | L 1-2 | 22-30 | 6 | 10,840 | Dave Roberts | Rick Jones | Enrique Romo | Bob Sykes | | 219 | 240 | -21 |
| 1977-06-10 | @ OAK | 53 | W 6-4 | 23-30 | 6 | 3,799 | Fernando Arroyo | Rick Langford | Fernando Arroyo | Rick Langford | Steve Foucault | 225 | 244 | -19 |
| 1977-06-11 | @ OAK | 54 | W 5-1 | 24-30 | 6 | 18,164 | Mark Fidrych | Dock Ellis | Mark Fidrych | Dock Ellis | | 230 | 245 | -15 |
| 1977-06-12 | @ OAK | 55 | L 1-7 | 24-31 | 6 | 5,120 | Dave Rozema | Vida Blue | Vida Blue | Dave Rozema | | 231 | 252 | -21 |
| 1977-06-14 | vs TOR | 56 | W 7-2 | 25-31 | 5 | 11,808 | John Hiller | Jesse Jefferson | John Hiller | Jesse Jefferson | | 238 | 254 | -16 |
| 1977-06-15 | vs TOR | 57 | W 9-0 | 26-31 | 5 | 11,349 | Fernando Arroyo | Dave Lemanczyk | Fernando Arroyo | Dave Lemanczyk | | 247 | 254 | -7 |
| 1977-06-16 | vs TOR | 58 | W 4-1 | 27-31 | 5 | 26,041 | Mark Fidrych | Jerry Garvin | Mark Fidrych | Jerry Garvin | | 251 | 255 | -4 |
| 1977-06-17 | @ CLE | 59 | L 5-8 | 27-32 | 5 | 21,452 | Dave Rozema | Rick Waits | Jim Kern | Jim Crawford | | 256 | 263 | -7 |
| 1977-06-18 | @ CLE | 60 | L 4-5 | 27-33 | 6 | 16,062 | Dave Roberts | Dennis Eckersley | Dennis Eckersley | Steve Foucault | | 260 | 268 | -8 |
| 1977-06-19 | @ CLE | 61 | L 2-4 | 27-35 | 6 | 0 | John Hiller | Wayne Garland | Wayne Garland | John Hiller | | 262 | 272 | -10 |
| 1977-06-19 | @ CLE | 62 | L 0-4 | 27-35 | 6 | 33,243 | Fernando Arroyo | Jim Bibby | Jim Bibby | Fernando Arroyo | | 262 | 276 | -14 |
| 1977-06-20 | vs NYA | 63 | W 2-1 | 28-35 | 6 | 47,236 | Mark Fidrych | Don Gullett | Mark Fidrych | Don Gullett | | 264 | 277 | -13 |
| 1977-06-21 | vs NYA | 64 | W 5-2 | 29-35 | 6 | 19,272 | Dave Rozema | Ron Guidry | Jim Crawford | Ron Guidry | | 269 | 279 | -10 |
| 1977-06-22 | vs NYA | 65 | L 11-12 | 29-36 | 6 | 18,129 | Dave Roberts | Ken Holtzman | Sparky Lyle | Steve Foucault | Ken Clay | 280 | 291 | -11 |
| 1977-06-24 | vs CLE | 66 | L 2-4 | 29-37 | 6 | 22,533 | Fernando Arroyo | Jim Bibby | Jim Bibby | Fernando Arroyo | | 282 | 295 | -13 |
| 1977-06-25 | vs CLE | 67 | W 6-4 | 30-37 | 6 | 37,279 | Mark Fidrych | Pat Dobson | Mark Fidrych | Pat Dobson | | 288 | 299 | -11 |
| 1977-06-26 | vs CLE | 68 | L 2-5 | 31-38 | 6 | 0 | John Hiller | Rick Waits | Rick Waits | John Hiller | Jim Kern | 290 | 304 | -14 |
| 1977-06-26 | vs CLE | 69 | W 3-2 | 31-38 | 6 | 30,582 | Bob Sykes | Wayne Garland | Bob Sykes | Wayne Garland | | 293 | 306 | -13 |
| 1977-06-27 | vs BOS | 70 | W 4-1 | 32-38 | 6 | 14,433 | Dave Roberts | Rick Wise | Dave Roberts | Rick Wise | | 297 | 307 | -10 |
| 1977-06-28 | vs BOS | 71 | W 3-2 | 33-38 | 6 | 13,403 | Fernando Arroyo | Fergie Jenkins | Jim Crawford | Bill Campbell | | 300 | 309 | -9 |
| 1977-06-29 | vs BOS | 72 | W 7-2 | 34-38 | 6 | 51,745 | Mark Fidrych | Bill Lee | Mark Fidrych | Bill Lee | | 307 | 311 | -4 |
| 1977-07-01 | @ NYA | 73 | W 5-1 | 35-38 | 6 | 22,876 | Dave Rozema | Mike Torrez | Dave Rozema | Mike Torrez | | 312 | 312 | 0 |
| 1977-07-02 | @ NYA | 74 | L 4-6 | 35-39 | 6 | 20,825 | Dave Roberts | Don Gullett | Sparky Lyle | John Hiller | | 316 | 318 | -2 |
| 1977-07-03 | @ NYA | 75 | L 0-2 | 36-40 | 6 | 42,549 | Fernando Arroyo | Ron Guidry | Ron Guidry | Fernando Arroyo | | 316 | 320 | -4 |
| 1977-07-03 | @ NYA | 76 | W 10-6 | 36-40 | 6 | 42,549 | Bob Sykes | Ken Holtzman | Steve Foucault | Dick Tidrow | | 326 | 326 | 0 |
| 1977-07-04 | @ BAL | 77 | L 4-6 | 36-41 | 6 | 45,339 | Mark Fidrych | Rudy May | Rudy May | Mark Fidrych | Tippy Martinez | 330 | 332 | -2 |
| 1977-07-05 | @ BAL | 78 | L 1-2 | 36-43 | 6 | 0 | Dave Rozema | Jim Palmer | Jim Palmer | Dave Rozema | | 331 | 334 | -3 |
| 1977-07-05 | @ BAL | 79 | L 5-6 | 36-43 | 6 | 11,565 | Milt Wilcox | Ross Grimsley | Dick Drago | Jim Crawford | | 336 | 340 | -4 |
| 1977-07-06 | @ BAL | 80 | L 0-2 | 36-44 | 6 | 7,341 | Dave Roberts | Mike Flanagan | Mike Flanagan | Dave Roberts | | 336 | 342 | -6 |
| 1977-07-08 | vs CHA | 81 | L 7-10 | 36-45 | 6 | 45,993 | Mark Fidrych | Chris Knapp | Don Kirkwood | Mark Fidrych | | 343 | 352 | -9 |
| 1977-07-09 | vs CHA | 82 | L 2-5 | 36-46 | 6 | 21,526 | Fernando Arroyo | Ken Kravec | Ken Kravec | Fernando Arroyo | Lerrin LaGrow | 345 | 357 | -12 |
| 1977-07-10 | vs CHA | 83 | W 6-5 | 37-46 | 6 | 21,008 | Bob Sykes | Wilbur Wood | Milt Wilcox | Dave Hamilton | | 351 | 362 | -11 |
| 1977-07-11 | vs TOR | 84 | W 9-7 | 38-46 | 6 | 9,057 | Dave Roberts | Mike Willis | Steve Grilli | Dennis DeBarr | | 360 | 369 | -9 |
| 1977-07-12 | vs TOR | 85 | W 2-1 | 39-46 | 5 | 25,007 | Mark Fidrych | Jesse Jefferson | Jim Crawford | Jesse Jefferson | | 362 | 370 | -8 |
| 1977-07-13 | @ KCA | 86 | L 4-6 | 39-47 | 6 | 19,418 | Fernando Arroyo | Andy Hassler | Doug Bird | Fernando Arroyo | Mark Littell | 366 | 376 | -10 |
| 1977-07-14 | @ KCA | 87 | L 3-4 | 39-48 | 6 | 20,755 | Bob Sykes | Jim Colborn | Jim Colborn | Bob Sykes | Larry Gura | 369 | 380 | -11 |
| 1977-07-15 | @ TOR | 88 | L 6-8 | 39-49 | 6 | 23,749 | Dave Roberts | Jeff Byrd | Pete Vuckovich | Jim Crawford | | 375 | 388 | -13 |
| 1977-07-16 | @ TOR | 89 | W 11-3 | 40-49 | 5 | 35,151 | Dave Rozema | Mike Willis | Dave Rozema | Mike Willis | | 386 | 391 | -5 |
| 1977-07-17 | @ TOR | 90 | L 2-3 | 41-50 | 6 | 0 | Fernando Arroyo | Jesse Jefferson | Jesse Jefferson | Fernando Arroyo | | 388 | 394 | -6 |
| 1977-07-17 | @ TOR | 91 | W 7-6 | 41-50 | 6 | 36,613 | Milt Wilcox | Dave Lemanczyk | John Hiller | Dave Lemanczyk | | 395 | 400 | -5 |
| 1977-07-21 | vs KCA | 92 | L 1-8 | 41-51 | 6 | 15,262 | Dave Roberts | Paul Splittorff | Paul Splittorff | Dave Roberts | | 396 | 408 | -12 |
| 1977-07-22 | vs KCA | 93 | L 4-5 | 41-52 | 6 | 22,758 | Fernando Arroyo | Dennis Leonard | Doug Bird | John Hiller | | 400 | 413 | -13 |
| 1977-07-23 | vs KCA | 94 | W 5-4 | 42-52 | 6 | 30,156 | Dave Rozema | Jim Colborn | Dave Rozema | Larry Gura | | 405 | 417 | -12 |
| 1977-07-24 | vs TOR | 95 | W 6-2 | 43-52 | 5 | 20,177 | Bob Sykes | Jesse Jefferson | Bob Sykes | Jesse Jefferson | | 411 | 419 | -8 |
| 1977-07-25 | vs TOR | 96 | W 8-3 | 44-52 | 4 | 16,911 | Milt Wilcox | Jeff Byrd | Milt Wilcox | Jeff Byrd | Jim Crawford | 419 | 422 | -3 |
| 1977-07-26 | @ CHA | 97 | L 3-8 | 44-53 | 5 | 23,099 | Dave Roberts | Chris Knapp | Chris Knapp | Dave Roberts | | 422 | 430 | -8 |
| 1977-07-27 | @ CHA | 98 | W 3-1 | 45-53 | 4 | 30,606 | Fernando Arroyo | Wilbur Wood | Fernando Arroyo | Wilbur Wood | John Hiller | 425 | 431 | -6 |
| 1977-07-29 | @ TEX | 99 | W 13-6 | 46-53 | 4 | 20,034 | Dave Rozema | Doyle Alexander | Dave Rozema | Doyle Alexander | | 438 | 437 | 1 |
| 1977-07-30 | @ TEX | 100 | L 5-6 | 46-54 | 4 | 22,369 | Bob Sykes | Dock Ellis | Paul Lindblad | John Hiller | | 443 | 443 | 0 |
| 1977-07-31 | @ TEX | 101 | L 2-3 | 46-55 | 4 | 16,309 | Jack Morris | Bert Blyleven | Adrian Devine | Jim Crawford | | 445 | 446 | -1 |
| 1977-08-03 | @ MIN | 102 | L 1-11 | 46-56 | 4 | 13,174 | Fernando Arroyo | Paul Thormodsgard | Paul Thormodsgard | Fernando Arroyo | | 446 | 457 | -11 |
| 1977-08-04 | @ MIN | 103 | W 4-2 | 47-56 | 4 | 18,060 | Dave Rozema | Pete Redfern | Dave Rozema | Pete Redfern | | 450 | 459 | -9 |
| 1977-08-05 | vs TEX | 104 | L 3-4 | 47-58 | 4 | 0 | Jack Morris | Gaylord Perry | Darold Knowles | John Hiller | | 453 | 463 | -10 |
| 1977-08-05 | vs TEX | 105 | L 0-6 | 47-58 | 4 | 27,094 | Bob Sykes | Nelson Briles | Nelson Briles | Bob Sykes | | 453 | 469 | -16 |
| 1977-08-06 | vs TEX | 106 | W 6-5 | 48-58 | 4 | 24,771 | Milt Wilcox | Doyle Alexander | Milt Wilcox | Doyle Alexander | Steve Foucault | 459 | 474 | -15 |
| 1977-08-07 | vs TEX | 107 | L 1-4 | 48-59 | 4 | 17,597 | Fernando Arroyo | Dock Ellis | Dock Ellis | Fernando Arroyo | | 460 | 478 | -18 |
| 1977-08-08 | vs MIL | 108 | W 6-1 | 49-59 | 4 | 11,973 | Jim Crawford | Mike Caldwell | Jim Crawford | Mike Caldwell | | 466 | 479 | -13 |
| 1977-08-09 | vs MIL | 109 | W 4-2 | 50-60 | 4 | 0 | Dave Rozema | Jim Slaton | Dave Rozema | Jim Slaton | | 470 | 481 | -11 |
| 1977-08-09 | vs MIL | 110 | L 4-6 | 50-60 | 4 | 18,099 | Bob Sykes | Bill Travers | Bill Travers | Steve Grilli | Bob McClure | 474 | 487 | -13 |
| 1977-08-10 | vs MIL | 111 | W 5-3 | 51-60 | 4 | 11,696 | Jack Morris | Jerry Augustine | Jack Morris | Jerry Augustine | Steve Foucault | 479 | 490 | -11 |
| 1977-08-12 | vs MIN | 112 | L 11-12 | 51-61 | 4 | 20,554 | Fernando Arroyo | Pete Redfern | Tom Burgmeier | Fernando Arroyo | Tom Johnson | 490 | 502 | -12 |
| 1977-08-13 | vs MIN | 113 | W 2-1 | 52-61 | 4 | 23,147 | Milt Wilcox | Geoff Zahn | Milt Wilcox | Geoff Zahn | Steve Foucault | 492 | 503 | -11 |
| 1977-08-14 | vs MIN | 114 | W 6-5 | 53-61 | 4 | 35,803 | Dave Rozema | Paul Thormodsgard | Dave Rozema | Tom Johnson | | 498 | 508 | -10 |
| 1977-08-15 | vs SEA | 115 | W 13-1 | 54-61 | 4 | 14,414 | Bob Sykes | Dick Pole | Bob Sykes | Dick Pole | | 511 | 509 | 2 |
| 1977-08-16 | vs SEA | 116 | L 2-3 | 54-62 | 4 | 9,065 | Jack Morris | Glenn Abbott | Glenn Abbott | Jack Morris | | 513 | 512 | 1 |
| 1977-08-17 | vs NYA | 117 | L 5-7 | 54-63 | 4 | 26,718 | Fernando Arroyo | Ed Figueroa | Ed Figueroa | Fernando Arroyo | Sparky Lyle | 518 | 519 | -1 |
| 1977-08-18 | vs NYA | 118 | L 4-5 | 54-64 | 4 | 27,564 | Jim Crawford | Catfish Hunter | Catfish Hunter | Jim Crawford | Sparky Lyle | 522 | 524 | -2 |
| 1977-08-19 | @ SEA | 119 | W 6-4 | 55-64 | 4 | 19,698 | Dave Rozema | Dick Pole | Dave Rozema | Dick Pole | Bruce Taylor | 528 | 528 | 0 |
| 1977-08-20 | @ SEA | 120 | W 7-3 | 56-64 | 4 | 55,670 | Milt Wilcox | Glenn Abbott | Milt Wilcox | Glenn Abbott | | 535 | 531 | 4 |
| 1977-08-21 | @ SEA | 121 | W 5-4 | 57-64 | 4 | 15,373 | Jack Morris | Paul Mitchell | Jim Crawford | Paul Mitchell | John Hiller | 540 | 535 | 5 |
| 1977-08-22 | @ CAL | 122 | W 5-1 | 58-64 | 4 | 24,304 | Fernando Arroyo | Paul Hartzell | Fernando Arroyo | Paul Hartzell | | 545 | 536 | 9 |
| 1977-08-23 | @ CAL | 123 | W 3-1 | 59-64 | 4 | 13,875 | Bob Sykes | Wayne Simpson | Bob Sykes | Wayne Simpson | Steve Foucault | 548 | 537 | 11 |
| 1977-08-24 | @ OAK | 124 | L 1-3 | 59-66 | 4 | 0 | Dave Rozema | Vida Blue | Vida Blue | Dave Rozema | | 549 | 540 | 9 |
| 1977-08-24 | @ OAK | 125 | L 5-6 | 59-66 | 4 | 7,324 | Milt Wilcox | Joe Coleman | Doug Bair | John Hiller | | 554 | 546 | 8 |
| 1977-08-26 | vs CAL | 126 | L 4-7 | 59-67 | 4 | 22,602 | Jack Morris | Frank Tanana | Dave LaRoche | Steve Foucault | | 558 | 553 | 5 |
| 1977-08-27 | vs CAL | 127 | W 7-6 | 60-67 | 4 | 23,105 | Fernando Arroyo | Paul Hartzell | John Hiller | Dave LaRoche | | 565 | 559 | 6 |
| 1977-08-28 | vs CAL | 128 | W 12-9 | 61-67 | 4 | 14,985 | Bob Sykes | Gary Nolan | Steve Foucault | Dyar Miller | | 577 | 568 | 9 |
| 1977-08-30 | @ MIL | 129 | W 4-2 | 62-67 | 4 | 7,349 | Dave Rozema | Mike Caldwell | Dave Rozema | Mike Caldwell | | 581 | 570 | 11 |
| 1977-08-31 | @ MIL | 130 | W 5-2 | 63-67 | 4 | 5,945 | Milt Wilcox | Jim Slaton | Milt Wilcox | Jim Slaton | | 586 | 572 | 14 |
| 1977-09-01 | @ MIL | 131 | L 0-1 | 63-68 | 4 | 3,985 | Fernando Arroyo | Jerry Augustine | Jerry Augustine | Fernando Arroyo | Eduardo Rodriguez | 586 | 573 | 13 |
| 1977-09-02 | vs OAK | 132 | W 6-4 | 64-68 | 4 | 11,500 | Jim Crawford | Vida Blue | Jim Crawford | Vida Blue | John Hiller | 592 | 577 | 15 |
| 1977-09-03 | vs OAK | 133 | W 10-8 | 65-68 | 4 | 11,159 | Bob Sykes | Joe Coleman | Ed Glynn | Bob Lacey | Steve Foucault | 602 | 585 | 17 |
| 1977-09-04 | vs OAK | 134 | L 5-7 | 65-69 | 4 | 15,906 | Dave Rozema | Rick Langford | Bob Lacey | Dave Rozema | Doug Bair | 607 | 592 | 15 |
| 1977-09-05 | vs BAL | 135 | W 8-7 | 66-70 | 4 | 22,062 | Milt Wilcox | Dennis Martinez | Jim Crawford | Dick Drago | | 615 | 599 | 16 |
| 1977-09-05 | vs BAL | 136 | L 0-5 | 66-70 | 4 | 22,062 | Steve Grilli | Rudy May | Rudy May | Steve Grilli | | 615 | 604 | 11 |
| 1977-09-06 | vs BAL | 137 | L 2-7 | 66-71 | 4 | 7,851 | Fernando Arroyo | Mike Flanagan | Mike Flanagan | Fernando Arroyo | | 617 | 611 | 6 |
| 1977-09-07 | vs BAL | 138 | L 2-6 | 67-72 | 4 | 11,032 | Jim Crawford | Scott McGregor | Scott McGregor | John Hiller | | 619 | 617 | 2 |
| 1977-09-07 | vs BAL | 139 | W 12-5 | 67-72 | 4 | 11,032 | Ed Glynn | Ross Grimsley | Ed Glynn | Ross Grimsley | | 631 | 622 | 9 |
| 1977-09-08 | vs BAL | 140 | L 0-4 | 67-73 | 4 | 1,969 | Bob Sykes | Jim Palmer | Jim Palmer | Bob Sykes | | 631 | 626 | 5 |
| 1977-09-09 | @ BOS | 141 | L 1-5 | 67-75 | 4 | 0 | Dave Rozema | Luis Tiant | Luis Tiant | Dave Rozema | Bill Campbell | 632 | 631 | 1 |
| 1977-09-09 | @ BOS | 142 | L 6-8 | 67-75 | 4 | 34,581 | Steve Grilli | Reggie Cleveland | Rick Wise | Vern Ruhle | Bill Campbell | 638 | 639 | -1 |
| 1977-09-10 | @ BOS | 143 | L 1-7 | 67-76 | 4 | 26,782 | Milt Wilcox | Don Aase | Don Aase | Milt Wilcox | | 639 | 646 | -7 |
| 1977-09-11 | @ BOS | 144 | L 2-6 | 67-77 | 4 | 34,325 | Fernando Arroyo | Bill Lee | Bill Lee | Fernando Arroyo | | 641 | 652 | -11 |
| 1977-09-12 | @ CLE | 145 | L 1-8 | 67-78 | 4 | 3,032 | Jim Crawford | Wayne Garland | Wayne Garland | Jim Crawford | | 642 | 660 | -18 |
| 1977-09-14 | @ CLE | 146 | W 5-3 | 69-78 | 4 | 0 | Bob Sykes | Jim Bibby | Bob Sykes | Jim Bibby | Bruce Taylor | 647 | 663 | -16 |
| 1977-09-14 | @ CLE | 147 | W 2-1 | 69-78 | 4 | 4,151 | Milt Wilcox | Don Hood | John Hiller | Jim Kern | Steve Foucault | 649 | 664 | -15 |
| 1977-09-16 | vs NYA | 148 | L 4-5 | 69-79 | 4 | 18,016 | Fernando Arroyo | Don Gullett | Don Gullett | Fernando Arroyo | | 653 | 669 | -16 |
| 1977-09-17 | vs NYA | 149 | L 4-9 | 69-80 | 4 | 17,656 | Jim Crawford | Dick Tidrow | Dick Tidrow | Jim Crawford | | 657 | 678 | -21 |
| 1977-09-18 | vs NYA | 150 | L 5-6 | 69-81 | 4 | 12,672 | Bob Sykes | Ron Guidry | Ron Guidry | Bob Sykes | Sparky Lyle | 662 | 684 | -22 |
| 1977-09-19 | vs CLE | 151 | W 6-4 | 70-81 | 4 | 5,843 | Milt Wilcox | Jim Bibby | Steve Foucault | Pat Dobson | | 668 | 688 | -20 |
| 1977-09-20 | vs CLE | 152 | W 5-4 | 71-81 | 4 | 5,557 | Ed Glynn | Don Hood | Steve Foucault | Rick Waits | | 673 | 692 | -19 |
| 1977-09-22 | vs BOS | 153 | W 5-4 | 72-81 | 4 | 3,507 | Fernando Arroyo | Don Aase | Fernando Arroyo | Jim Willoughby | Steve Foucault | 678 | 696 | -18 |
| 1977-09-23 | vs BOS | 154 | L 1-5 | 72-82 | 4 | 11,344 | Bob Sykes | Bill Lee | Bill Lee | Bob Sykes | | 679 | 701 | -22 |
| 1977-09-24 | vs BOS | 155 | L 2-6 | 72-83 | 4 | 9,245 | Milt Wilcox | Mike Paxton | Mike Paxton | Milt Wilcox | Bill Campbell | 681 | 707 | -26 |
| 1977-09-25 | vs BOS | 156 | L 5-12 | 72-84 | 4 | 12,707 | Ed Glynn | Reggie Cleveland | Reggie Cleveland | Ed Glynn | | 686 | 719 | -33 |
| 1977-09-27 | @ BAL | 157 | L 1-6 | 72-85 | 4 | 4,854 | Fernando Arroyo | Mike Flanagan | Mike Flanagan | Fernando Arroyo | | 687 | 725 | -38 |
| 1977-09-28 | @ BAL | 158 | L 2-3 | 72-86 | 4 | 7,547 | Vern Ruhle | Jim Palmer | Jim Palmer | Steve Foucault | | 689 | 728 | -39 |
| 1977-09-29 | @ BAL | 159 | L 3-6 | 72-87 | 4 | 6,241 | Jim Crawford | Rudy May | Rudy May | Jim Crawford | Tippy Martinez | 692 | 734 | -42 |
| 1977-09-30 | @ NYA | 160 | W 5-2 | 73-87 | 4 | 28,200 | John Hiller | Ron Guidry | John Hiller | Ron Guidry | | 697 | 736 | -39 |
| 1977-10-01 | @ NYA | 161 | W 10-7 | 74-87 | 4 | 50,054 | Fernando Arroyo | Mike Torrez | Bruce Taylor | Larry McCall | | 707 | 743 | -36 |
| 1977-10-02 | @ NYA | 162 | L 7-8 | 74-88 | 4 | 18,778 | Vern Ruhle | Ken Clay | Stan Thomas | Steve Foucault | | 714 | 751 | -37 |