| 1976-04-09 | vs KCA | 1 | W 4-0 | 1-0 | 1 | 40,318 | Wilbur Wood | Paul Splittorff | Wilbur Wood | Paul Splittorff | | 4 | 0 | 4 |
| 1976-04-13 | @ MIN | 2 | W 4-1 | 2-0 | 1 | 20,732 | Rich Gossage | Bert Blyleven | Rich Gossage | Bert Blyleven | | 8 | 1 | 7 |
| 1976-04-14 | @ MIN | 3 | L 2-6 | 2-1 | 2 | 4,046 | Wilbur Wood | Joe Decker | Joe Decker | Wilbur Wood | Bill Campbell | 10 | 7 | 3 |
| 1976-04-15 | @ BOS | 4 | W 8-4 | 3-1 | 2 | 10,916 | Bart Johnson | Rick Wise | Bart Johnson | Rick Wise | Clay Carroll | 18 | 11 | 7 |
| 1976-04-17 | @ BOS | 5 | L 1-7 | 3-2 | 2 | 24,328 | Terry Forster | Luis Tiant | Luis Tiant | Rich Gossage | | 19 | 18 | 1 |
| 1976-04-18 | @ BOS | 6 | W 10-4 | 4-2 | 1 | 18,971 | Wilbur Wood | Bill Lee | Wilbur Wood | Bill Lee | | 29 | 22 | 7 |
| 1976-04-20 | @ NYA | 7 | L 4-5 | 4-3 | 3 | 20,337 | Bart Johnson | Dock Ellis | Tippy Martinez | Bart Johnson | Sparky Lyle | 33 | 27 | 6 |
| 1976-04-21 | @ NYA | 8 | L 7-10 | 4-4 | 3 | 19,616 | Dave Hamilton | Rudy May | Rudy May | Dave Hamilton | | 40 | 37 | 3 |
| 1976-04-23 | vs BOS | 9 | L 2-9 | 4-5 | 4 | 11,920 | Wilbur Wood | Luis Tiant | Luis Tiant | Wilbur Wood | | 42 | 46 | -4 |
| 1976-04-28 | vs MIL | 10 | L 1-4 | 4-6 | 4 | 1,144 | Wilbur Wood | Bill Travers | Bill Travers | Wilbur Wood | Eduardo Rodriguez | 43 | 50 | -7 |
| 1976-04-29 | vs MIL | 11 | L 5-8 | 4-7 | 4 | 1,709 | Rich Gossage | Jim Slaton | Eduardo Rodriguez | Clay Carroll | | 48 | 58 | -10 |
| 1976-04-30 | vs DET | 12 | W 8-4 | 5-7 | 3 | 9,009 | Terry Forster | Ray Bare | Terry Forster | Ray Bare | | 56 | 62 | -6 |
| 1976-05-01 | vs DET | 13 | L 1-10 | 5-8 | 5 | 17,402 | Bart Johnson | Vern Ruhle | Vern Ruhle | Bart Johnson | | 57 | 72 | -15 |
| 1976-05-04 | @ BAL | 14 | W 3-1 | 6-8 | 5 | 6,160 | Wilbur Wood | Ken Holtzman | Wilbur Wood | Ken Holtzman | | 60 | 73 | -13 |
| 1976-05-05 | @ BAL | 15 | L 0-2 | 6-9 | 5 | 6,570 | Rich Gossage | Jim Palmer | Jim Palmer | Rich Gossage | | 60 | 75 | -15 |
| 1976-05-07 | @ DET | 16 | L 0-5 | 6-10 | 5 | 10,059 | Terry Forster | Ray Bare | Ray Bare | Terry Forster | | 60 | 80 | -20 |
| 1976-05-08 | @ DET | 17 | L 1-7 | 6-11 | 6 | 11,802 | Bart Johnson | Vern Ruhle | Vern Ruhle | Bart Johnson | Bill Laxton | 61 | 87 | -26 |
| 1976-05-09 | @ DET | 18 | W 4-2 | 7-11 | 5 | 12,250 | Wilbur Wood | Joe Coleman | Wilbur Wood | Joe Coleman | Clay Carroll | 65 | 89 | -24 |
| 1976-05-10 | @ TEX | 19 | W 7-6 | 8-11 | 5 | 15,333 | Rich Gossage | Nelson Briles | Dave Hamilton | Steve Hargan | | 72 | 95 | -23 |
| 1976-05-11 | @ TEX | 20 | L 5-6 | 8-12 | 5 | 14,713 | Terry Forster | Steve Barr | Jeff Terpko | Dave Hamilton | | 77 | 101 | -24 |
| 1976-05-13 | @ KCA | 21 | L 2-13 | 8-13 | 5 | 13,657 | Bart Johnson | Dennis Leonard | Dennis Leonard | Bart Johnson | | 79 | 114 | -35 |
| 1976-05-14 | @ KCA | 22 | L 1-7 | 8-14 | 5 | 12,990 | Pete Vuckovich | Al Fitzmorris | Al Fitzmorris | Pete Vuckovich | | 80 | 121 | -41 |
| 1976-05-15 | @ KCA | 23 | L 1-2 | 8-15 | 5 | 14,693 | Rich Gossage | Paul Splittorff | Mark Littell | Rich Gossage | | 81 | 123 | -42 |
| 1976-05-16 | @ KCA | 24 | W 4-3 | 9-15 | 5 | 28,413 | Terry Forster | Doug Bird | Clay Carroll | Doug Bird | Dave Hamilton | 85 | 126 | -41 |
| 1976-05-17 | vs CAL | 25 | L 5-10 | 9-16 | 6 | 4,921 | Jesse Jefferson | Frank Tanana | Frank Tanana | Jesse Jefferson | | 90 | 136 | -46 |
| 1976-05-18 | vs CAL | 26 | W 5-0 | 10-16 | 5 | 6,441 | Bart Johnson | Nolan Ryan | Bart Johnson | Nolan Ryan | | 95 | 136 | -41 |
| 1976-05-19 | vs MIN | 27 | W 4-1 | 11-16 | 5 | 7,136 | Pete Vuckovich | Bert Blyleven | Pete Vuckovich | Bert Blyleven | Dave Hamilton | 99 | 137 | -38 |
| 1976-05-20 | vs MIN | 28 | W 3-2 | 12-16 | 5 | 6,999 | Rich Gossage | Pete Redfern | Rich Gossage | Pete Redfern | | 102 | 139 | -37 |
| 1976-05-21 | vs OAK | 29 | W 6-0 | 13-16 | 4 | 22,420 | Ken Brett | Vida Blue | Ken Brett | Vida Blue | Clay Carroll | 108 | 139 | -31 |
| 1976-05-22 | vs OAK | 30 | W 7-2 | 14-16 | 4 | 16,797 | Jesse Jefferson | Mike Norris | Jesse Jefferson | Mike Norris | | 115 | 141 | -26 |
| 1976-05-23 | vs OAK | 31 | W 3-1 | 16-16 | 4 | 0 | Terry Forster | Mike Torrez | Clay Carroll | Mike Torrez | | 118 | 142 | -24 |
| 1976-05-23 | vs OAK | 32 | W 4-3 | 16-16 | 4 | 21,539 | Bart Johnson | Stan Bahnsen | Bart Johnson | Stan Bahnsen | Clay Carroll | 122 | 145 | -23 |
| 1976-05-24 | @ CAL | 33 | W 5-3 | 17-16 | 3 | 16,016 | Pete Vuckovich | Sid Monge | Pete Vuckovich | Jim Brewer | | 127 | 148 | -21 |
| 1976-05-25 | @ CAL | 34 | W 7-1 | 18-16 | 3 | 6,844 | Rich Gossage | Gary Ross | Rich Gossage | Gary Ross | | 134 | 149 | -15 |
| 1976-05-26 | @ CAL | 35 | W 1-0 | 19-16 | 3 | 6,569 | Ken Brett | Don Kirkwood | Ken Brett | Don Kirkwood | Clay Carroll | 135 | 149 | -14 |
| 1976-05-27 | @ CAL | 36 | L 3-5 | 19-17 | 3 | 7,277 | Jesse Jefferson | Frank Tanana | Frank Tanana | Francisco Barrios | | 138 | 154 | -16 |
| 1976-05-28 | @ OAK | 37 | L 0-11 | 19-18 | 3 | 3,688 | Bart Johnson | Stan Bahnsen | Stan Bahnsen | Bart Johnson | | 138 | 165 | -27 |
| 1976-05-29 | @ OAK | 38 | L 0-2 | 19-19 | 3 | 4,988 | Terry Forster | Vida Blue | Vida Blue | Terry Forster | | 138 | 167 | -29 |
| 1976-05-30 | @ OAK | 39 | W 4-3 | 20-19 | 3 | 6,056 | Rich Gossage | Dick Bosman | Clay Carroll | Rollie Fingers | Dave Hamilton | 142 | 170 | -28 |
| 1976-05-31 | vs TEX | 40 | W 9-4 | 21-19 | 3 | 16,065 | Pete Vuckovich | Nelson Briles | Pete Vuckovich | Nelson Briles | | 151 | 174 | -23 |
| 1976-06-01 | vs TEX | 41 | L 5-6 | 21-20 | 3 | 8,736 | Ken Brett | Bill Singer | Steve Foucault | Jesse Jefferson | | 156 | 180 | -24 |
| 1976-06-02 | vs TEX | 42 | W 1-0 | 22-20 | 3 | 8,013 | Bart Johnson | Jim Umbarger | Dave Hamilton | Jim Umbarger | | 157 | 180 | -23 |
| 1976-06-04 | vs CLE | 43 | W 4-1 | 23-20 | 3 | 25,883 | Rich Gossage | Dennis Eckersley | Rich Gossage | Dennis Eckersley | | 161 | 181 | -20 |
| 1976-06-05 | vs CLE | 44 | L 3-5 | 23-21 | 3 | 13,744 | Terry Forster | Pat Dobson | Jim Kern | Clay Carroll | | 164 | 186 | -22 |
| 1976-06-06 | vs CLE | 45 | W 3-2 | 25-21 | 3 | 0 | Pete Vuckovich | Jackie Brown | Pete Vuckovich | Jackie Brown | Francisco Barrios | 167 | 188 | -21 |
| 1976-06-06 | vs CLE | 46 | W 5-0 | 25-21 | 3 | 24,413 | Ken Brett | Don Hood | Ken Brett | Don Hood | | 172 | 188 | -16 |
| 1976-06-08 | @ MIL | 47 | L 0-2 | 25-22 | 3 | 17,973 | Bart Johnson | Bill Travers | Bill Travers | Bart Johnson | | 172 | 190 | -18 |
| 1976-06-09 | @ MIL | 48 | W 4-2 | 26-22 | 3 | 16,290 | Rich Gossage | Jim Slaton | Rich Gossage | Jim Slaton | Clay Carroll | 176 | 192 | -16 |
| 1976-06-10 | @ MIL | 49 | W 12-5 | 27-22 | 3 | 12,769 | Francisco Barrios | Jerry Augustine | Francisco Barrios | Jerry Augustine | | 188 | 197 | -9 |
| 1976-06-11 | @ CLE | 50 | L 4-5 | 27-23 | 3 | 11,984 | Ken Brett | Jackie Brown | Jim Kern | Terry Forster | | 192 | 202 | -10 |
| 1976-06-12 | @ CLE | 51 | L 0-3 | 27-24 | 3 | 17,456 | Pete Vuckovich | Rick Waits | Rick Waits | Pete Vuckovich | Jim Bibby | 192 | 205 | -13 |
| 1976-06-13 | @ CLE | 52 | L 5-8 | 27-26 | 3 | 0 | Bart Johnson | Pat Dobson | Pat Dobson | Bart Johnson | Dave LaRoche | 197 | 213 | -16 |
| 1976-06-13 | @ CLE | 53 | L 7-9 | 27-26 | 3 | 33,599 | Jesse Jefferson | Dennis Eckersley | Jim Kern | Clay Carroll | Dave LaRoche | 204 | 222 | -18 |
| 1976-06-15 | vs BAL | 54 | L 0-4 | 27-27 | 3 | 10,794 | Rich Gossage | Jim Palmer | Jim Palmer | Rich Gossage | | 204 | 226 | -22 |
| 1976-06-16 | vs BAL | 55 | L 2-10 | 27-28 | 3 | 13,827 | Francisco Barrios | Mike Cuellar | Mike Cuellar | Francisco Barrios | | 206 | 236 | -30 |
| 1976-06-17 | vs NYA | 56 | L 4-5 | 27-29 | 4 | 16,320 | Terry Forster | Catfish Hunter | Catfish Hunter | Terry Forster | Sparky Lyle | 210 | 241 | -31 |
| 1976-06-18 | vs NYA | 57 | L 2-3 | 27-30 | 4 | 22,897 | Bart Johnson | Ken Holtzman | Grant Jackson | Dave Hamilton | | 212 | 244 | -32 |
| 1976-06-19 | vs NYA | 58 | L 3-4 | 27-31 | 5 | 25,483 | Rich Gossage | Doyle Alexander | Doyle Alexander | Rich Gossage | Sparky Lyle | 215 | 248 | -33 |
| 1976-06-20 | vs NYA | 59 | L 3-6 | 27-32 | 5 | 40,848 | Ken Brett | Dock Ellis | Dock Ellis | Ken Brett | Sparky Lyle | 218 | 254 | -36 |
| 1976-06-21 | @ KCA | 60 | W 2-1 | 28-32 | 5 | 28,918 | Francisco Barrios | Paul Splittorff | Dave Hamilton | Tom Hall | | 220 | 255 | -35 |
| 1976-06-22 | @ KCA | 61 | W 14-8 | 29-32 | 5 | 18,125 | Jesse Jefferson | Steve Busby | Jesse Jefferson | Steve Busby | | 234 | 263 | -29 |
| 1976-06-23 | @ MIN | 62 | W 4-3 | 31-32 | 4 | 0 | Bart Johnson | Joe Decker | Bart Johnson | Joe Decker | Terry Forster | 238 | 266 | -28 |
| 1976-06-23 | @ MIN | 63 | W 9-5 | 31-32 | 4 | 9,540 | Chris Knapp | Pete Redfern | Pete Vuckovich | Pete Redfern | Ken Brett | 247 | 271 | -24 |
| 1976-06-24 | @ MIN | 64 | L 2-4 | 31-33 | 4 | 12,790 | Rich Gossage | Bill Singer | Bill Singer | Rich Gossage | | 249 | 275 | -26 |
| 1976-06-25 | @ TEX | 65 | L 4-8 | 32-34 | 4 | 0 | Terry Forster | Gaylord Perry | Gaylord Perry | Dave Hamilton | | 253 | 283 | -30 |
| 1976-06-25 | @ TEX | 66 | W 14-9 | 32-34 | 4 | 29,049 | Francisco Barrios | Steve Barr | Pete Vuckovich | Steve Foucault | | 267 | 292 | -25 |
| 1976-06-26 | @ TEX | 67 | L 0-1 | 32-35 | 4 | 20,903 | Ken Brett | Bert Blyleven | Bert Blyleven | Ken Brett | | 267 | 293 | -26 |
| 1976-06-27 | @ TEX | 68 | W 6-2 | 33-35 | 4 | 12,567 | Bart Johnson | Nelson Briles | Bart Johnson | Nelson Briles | Dave Hamilton | 273 | 295 | -22 |
| 1976-06-29 | vs CAL | 69 | L 1-4 | 33-36 | 4 | 10,645 | Francisco Barrios | Frank Tanana | Frank Tanana | Francisco Barrios | | 274 | 299 | -25 |
| 1976-06-30 | vs CAL | 70 | L 1-2 | 33-37 | 4 | 14,745 | Jesse Jefferson | Nolan Ryan | Dick Drago | Clay Carroll | | 275 | 301 | -26 |
| 1976-07-01 | vs CAL | 71 | L 1-2 | 33-38 | 4 | 9,522 | Ken Brett | Sid Monge | Sid Monge | Ken Brett | Mickey Scott | 276 | 303 | -27 |
| 1976-07-02 | vs TEX | 72 | W 1-0 | 34-38 | 4 | 17,162 | Bart Johnson | Bert Blyleven | Bart Johnson | Bert Blyleven | | 277 | 303 | -26 |
| 1976-07-03 | vs TEX | 73 | L 0-3 | 34-39 | 5 | 10,099 | Terry Forster | Nelson Briles | Nelson Briles | Terry Forster | | 277 | 306 | -29 |
| 1976-07-04 | vs TEX | 74 | W 7-6 | 35-40 | 5 | 0 | Francisco Barrios | Jim Umbarger | Dave Hamilton | Mike Bacsik | | 284 | 312 | -28 |
| 1976-07-04 | vs TEX | 75 | L 2-3 | 35-40 | 5 | 15,689 | Chris Knapp | Steve Hargan | Steve Hargan | Chris Knapp | Joe Hoerner | 286 | 315 | -29 |
| 1976-07-05 | @ BOS | 76 | L 2-11 | 35-41 | 5 | 24,640 | Jesse Jefferson | Luis Tiant | Luis Tiant | Jesse Jefferson | | 288 | 326 | -38 |
| 1976-07-06 | @ BOS | 77 | L 0-4 | 35-42 | 5 | 31,423 | Ken Brett | Fergie Jenkins | Fergie Jenkins | Ken Brett | | 288 | 330 | -42 |
| 1976-07-07 | @ BOS | 78 | W 6-3 | 36-42 | 5 | 27,281 | Bart Johnson | Dick Pole | Bart Johnson | Jim Willoughby | Dave Hamilton | 294 | 333 | -39 |
| 1976-07-08 | @ NYA | 79 | L 0-6 | 36-43 | 5 | 14,545 | Rich Gossage | Ken Holtzman | Ken Holtzman | Rich Gossage | | 294 | 339 | -45 |
| 1976-07-09 | @ NYA | 80 | L 1-2 | 36-44 | 5 | 21,097 | Francisco Barrios | Dock Ellis | Dock Ellis | Terry Forster | Sparky Lyle | 295 | 341 | -46 |
| 1976-07-10 | @ NYA | 81 | W 4-1 | 37-44 | 5 | 25,348 | Ken Brett | Doyle Alexander | Ken Brett | Doyle Alexander | | 299 | 342 | -43 |
| 1976-07-11 | @ NYA | 82 | L 0-5 | 37-45 | 5 | 53,160 | Bart Johnson | Ed Figueroa | Ed Figueroa | Bart Johnson | | 299 | 347 | -48 |
| 1976-07-15 | vs MIL | 83 | W 5-3 | 38-45 | 5 | 13,892 | Ken Brett | Jim Slaton | Ken Brett | Jim Slaton | | 304 | 350 | -46 |
| 1976-07-16 | vs MIL | 84 | W 5-2 | 39-45 | 5 | 16,791 | Bart Johnson | Jerry Augustine | Bart Johnson | Jerry Augustine | Dave Hamilton | 309 | 352 | -43 |
| 1976-07-17 | vs MIL | 85 | L 2-9 | 39-46 | 5 | 15,261 | Rich Gossage | Jim Colborn | Jim Colborn | Rich Gossage | | 311 | 361 | -50 |
| 1976-07-18 | vs MIL | 86 | W 13-3 | 40-46 | 4 | 20,302 | Francisco Barrios | Bill Travers | Francisco Barrios | Bill Travers | | 324 | 364 | -40 |
| 1976-07-19 | vs NYA | 87 | L 2-3 | 40-47 | 5 | 11,544 | Terry Forster | Ed Figueroa | Ed Figueroa | Dave Hamilton | Sparky Lyle | 326 | 367 | -41 |
| 1976-07-20 | vs NYA | 88 | L 9-14 | 40-48 | 5 | 19,776 | Ken Brett | Ken Holtzman | Jim York | Pete Vuckovich | | 335 | 381 | -46 |
| 1976-07-21 | vs DET | 89 | W 4-1 | 42-48 | 4 | 0 | Chris Knapp | Vern Ruhle | Chris Knapp | Vern Ruhle | | 339 | 382 | -43 |
| 1976-07-21 | vs DET | 90 | W 3-0 | 42-48 | 4 | 10,765 | Bart Johnson | Dave Lemanczyk | Bart Johnson | Dave Lemanczyk | | 342 | 382 | -40 |
| 1976-07-22 | vs DET | 91 | W 9-3 | 43-49 | 5 | 0 | Blue Moon Odom | Frank MacCormack | Blue Moon Odom | Frank MacCormack | | 351 | 385 | -34 |
| 1976-07-22 | vs DET | 92 | L 1-5 | 43-49 | 5 | 9,077 | Rich Gossage | Ray Bare | Ray Bare | Rich Gossage | John Hiller | 352 | 390 | -38 |
| 1976-07-23 | vs MIN | 93 | L 2-6 | 43-50 | 5 | 10,126 | Francisco Barrios | Jim Hughes | Tom Burgmeier | Francisco Barrios | | 354 | 396 | -42 |
| 1976-07-24 | vs MIN | 94 | L 2-17 | 43-51 | 5 | 14,997 | Jesse Jefferson | Eddie Bane | Eddie Bane | Jesse Jefferson | | 356 | 413 | -57 |
| 1976-07-25 | vs MIN | 95 | L 8-13 | 44-52 | 5 | 0 | Terry Forster | Steve Luebber | Vic Albury | Terry Forster | | 364 | 426 | -62 |
| 1976-07-25 | vs MIN | 96 | W 7-4 | 44-52 | 5 | 12,651 | Ken Brett | Bill Singer | Ken Brett | Bill Singer | | 371 | 430 | -59 |
| 1976-07-26 | @ OAK | 97 | L 1-3 | 44-53 | 5 | 23,182 | Bart Johnson | Paul Mitchell | Paul Mitchell | Bart Johnson | Rollie Fingers | 372 | 433 | -61 |
| 1976-07-27 | @ OAK | 98 | L 0-1 | 44-54 | 5 | 3,442 | Rich Gossage | Vida Blue | Vida Blue | Rich Gossage | | 372 | 434 | -62 |
| 1976-07-28 | @ OAK | 99 | W 2-1 | 45-54 | 5 | 3,367 | Blue Moon Odom | Mike Torrez | Blue Moon Odom | Paul Lindblad | Francisco Barrios | 374 | 435 | -61 |
| 1976-07-30 | @ CAL | 100 | L 0-3 | 45-55 | 5 | 8,878 | Ken Brett | Nolan Ryan | Nolan Ryan | Ken Brett | | 374 | 438 | -64 |
| 1976-07-31 | @ CAL | 101 | L 2-3 | 45-56 | 5 | 31,314 | Bart Johnson | Gary Ross | Dick Drago | Terry Forster | | 376 | 441 | -65 |
| 1976-08-01 | @ CAL | 102 | W 2-1 | 46-56 | 5 | 9,282 | Rich Gossage | Frank Tanana | Rich Gossage | Frank Tanana | | 378 | 442 | -64 |
| 1976-08-03 | vs OAK | 103 | L 3-7 | 46-57 | 5 | 10,063 | Blue Moon Odom | Dick Bosman | Dick Bosman | Blue Moon Odom | Rollie Fingers | 381 | 449 | -68 |
| 1976-08-04 | vs OAK | 104 | L 0-5 | 46-58 | 5 | 8,892 | Ken Brett | Paul Mitchell | Paul Mitchell | Ken Brett | | 381 | 454 | -73 |
| 1976-08-06 | vs KCA | 105 | L 2-9 | 46-60 | 6 | 0 | Bart Johnson | Andy Hassler | Andy Hassler | Bart Johnson | | 383 | 463 | -80 |
| 1976-08-06 | vs KCA | 106 | L 3-8 | 46-60 | 6 | 13,284 | Rich Gossage | Doug Bird | Doug Bird | Rich Gossage | | 386 | 471 | -85 |
| 1976-08-07 | vs KCA | 107 | W 5-3 | 47-60 | 5 | 30,382 | Francisco Barrios | Larry Gura | Francisco Barrios | Steve Mingori | | 391 | 474 | -83 |
| 1976-08-08 | vs KCA | 108 | W 5-2 | 48-61 | 5 | 0 | Terry Forster | Marty Pattin | Terry Forster | Marty Pattin | Rich Gossage | 396 | 476 | -80 |
| 1976-08-08 | vs KCA | 109 | L 1-7 | 48-61 | 5 | 15,997 | Jesse Jefferson | Al Fitzmorris | Al Fitzmorris | Jesse Jefferson | | 397 | 483 | -86 |
| 1976-08-09 | @ CLE | 110 | L 2-4 | 48-62 | 5 | 6,026 | Ken Brett | Jim Bibby | Jim Bibby | Ken Brett | Dave LaRoche | 399 | 487 | -88 |
| 1976-08-11 | @ CLE | 111 | L 3-4 | 48-63 | 6 | 7,090 | Bart Johnson | Jackie Brown | Jim Kern | Francisco Barrios | | 402 | 491 | -89 |
| 1976-08-13 | @ BAL | 112 | W 5-2 | 49-63 | 5 | 10,906 | Rich Gossage | Rudy May | Rich Gossage | Rudy May | Dave Hamilton | 407 | 493 | -86 |
| 1976-08-14 | @ BAL | 113 | L 6-8 | 49-65 | 5 | 0 | Terry Forster | Jim Palmer | Jim Palmer | Terry Forster | Fred Holdsworth | 413 | 501 | -88 |
| 1976-08-14 | @ BAL | 114 | L 5-6 | 49-65 | 5 | 16,514 | Ken Brett | Mike Flanagan | Dyar Miller | Ken Brett | Tippy Martinez | 418 | 507 | -89 |
| 1976-08-15 | @ BAL | 115 | L 0-3 | 49-66 | 5 | 8,486 | Francisco Barrios | Wayne Garland | Wayne Garland | Francisco Barrios | | 418 | 510 | -92 |
| 1976-08-16 | vs BOS | 116 | L 5-12 | 49-67 | 6 | 7,733 | Bart Johnson | Luis Tiant | Luis Tiant | Bart Johnson | Bill Lee | 423 | 522 | -99 |
| 1976-08-17 | vs BOS | 117 | W 2-1 | 50-68 | 5 | 0 | Ken Kravec | Reggie Cleveland | Clay Carroll | Tom Murphy | | 425 | 523 | -98 |
| 1976-08-17 | vs BOS | 118 | L 7-11 | 50-68 | 5 | 18,416 | Blue Moon Odom | Rick Kreuger | Dick Pole | Blue Moon Odom | | 432 | 534 | -102 |
| 1976-08-18 | vs BOS | 119 | W 4-2 | 51-68 | 5 | 10,136 | Rich Gossage | Fergie Jenkins | Rich Gossage | Fergie Jenkins | | 436 | 536 | -100 |
| 1976-08-19 | vs BOS | 120 | W 4-2 | 52-68 | 5 | 10,636 | Ken Brett | Rick Wise | Ken Brett | Rick Wise | | 440 | 538 | -98 |
| 1976-08-20 | vs BAL | 121 | L 4-6 | 52-69 | 5 | 16,257 | Francisco Barrios | Wayne Garland | Wayne Garland | Francisco Barrios | | 444 | 544 | -100 |
| 1976-08-21 | vs BAL | 122 | W 11-10 | 53-69 | 5 | 32,607 | Bart Johnson | Rudy May | Dave Hamilton | Mike Cuellar | | 455 | 554 | -99 |
| 1976-08-22 | vs BAL | 123 | L 2-6 | 54-70 | 5 | 0 | Ken Kravec | Jim Palmer | Jim Palmer | Ken Kravec | | 457 | 560 | -103 |
| 1976-08-22 | vs BAL | 124 | W 7-3 | 54-70 | 5 | 16,991 | Pete Vuckovich | Ross Grimsley | Pete Vuckovich | Ross Grimsley | Francisco Barrios | 464 | 563 | -99 |
| 1976-08-23 | @ DET | 125 | L 4-5 | 54-71 | 5 | 13,426 | Rich Gossage | Ray Bare | Ray Bare | Rich Gossage | | 468 | 568 | -100 |
| 1976-08-24 | @ DET | 126 | W 12-7 | 55-71 | 5 | 9,503 | Ken Brett | Dave Roberts | Dave Hamilton | Jim Crawford | | 480 | 575 | -95 |
| 1976-08-25 | @ DET | 127 | L 1-3 | 55-72 | 5 | 39,884 | Bart Johnson | Mark Fidrych | Mark Fidrych | Bart Johnson | | 481 | 578 | -97 |
| 1976-08-27 | @ MIL | 128 | W 5-2 | 56-72 | 5 | 14,950 | Ken Kravec | Jim Slaton | Ken Kravec | Jim Slaton | Dave Hamilton | 486 | 580 | -94 |
| 1976-08-28 | @ MIL | 129 | L 8-10 | 56-73 | 5 | 15,934 | Rich Gossage | Jim Colborn | Jim Colborn | Rich Gossage | | 494 | 590 | -96 |
| 1976-08-29 | @ MIL | 130 | W 2-0 | 57-73 | 5 | 22,225 | Ken Brett | Eduardo Rodriguez | Ken Brett | Eduardo Rodriguez | Dave Hamilton | 496 | 590 | -94 |
| 1976-08-31 | vs CLE | 131 | L 2-4 | 57-74 | 6 | 10,852 | Bart Johnson | Rick Waits | Jim Kern | Dave Hamilton | Dave LaRoche | 498 | 594 | -96 |
| 1976-09-01 | vs CLE | 132 | L 0-3 | 57-75 | 6 | 6,225 | Ken Kravec | Jim Bibby | Jim Bibby | Ken Kravec | | 498 | 597 | -99 |
| 1976-09-03 | @ MIN | 133 | L 1-11 | 57-76 | 6 | 4,622 | Rich Gossage | Pete Redfern | Pete Redfern | Rich Gossage | Tom Burgmeier | 499 | 608 | -109 |
| 1976-09-04 | @ MIN | 134 | W 4-0 | 58-76 | 6 | 5,933 | Ken Brett | Jim Hughes | Ken Brett | Jim Hughes | | 503 | 608 | -105 |
| 1976-09-05 | @ MIN | 135 | L 1-18 | 58-77 | 6 | 6,602 | Bart Johnson | Eddie Bane | Tom Johnson | Bart Johnson | | 504 | 626 | -122 |
| 1976-09-06 | @ MIN | 136 | L 2-3 | 58-78 | 6 | 6,587 | Ken Kravec | Bill Singer | Bill Campbell | Francisco Barrios | | 506 | 629 | -123 |
| 1976-09-07 | @ OAK | 137 | L 0-4 | 58-79 | 6 | 3,461 | Terry Forster | Mike Torrez | Mike Torrez | Terry Forster | | 506 | 633 | -127 |
| 1976-09-08 | @ OAK | 138 | W 6-5 | 59-79 | 6 | 5,328 | Rich Gossage | Dick Bosman | Chris Knapp | Rollie Fingers | | 512 | 638 | -126 |
| 1976-09-09 | @ OAK | 139 | L 1-2 | 59-80 | 6 | 6,617 | Ken Brett | Mike Norris | Jim Todd | Ken Brett | Rollie Fingers | 513 | 640 | -127 |
| 1976-09-10 | vs CAL | 140 | L 2-3 | 59-81 | 6 | 6,575 | Bart Johnson | Nolan Ryan | Nolan Ryan | Bart Johnson | | 515 | 643 | -128 |
| 1976-09-11 | vs CAL | 141 | L 3-7 | 59-82 | 6 | 6,596 | Ken Kravec | Frank Tanana | Frank Tanana | Ken Kravec | Dick Drago | 518 | 650 | -132 |
| 1976-09-12 | vs CAL | 142 | W 2-1 | 61-82 | 6 | 0 | Rich Gossage | Sid Monge | Rich Gossage | Sid Monge | | 520 | 651 | -131 |
| 1976-09-12 | vs CAL | 143 | W 5-1 | 61-82 | 6 | 11,919 | Francisco Barrios | Don Kirkwood | Francisco Barrios | Don Kirkwood | | 525 | 652 | -127 |
| 1976-09-13 | vs KCA | 144 | W 4-3 | 63-82 | 6 | 0 | Chris Knapp | Dennis Leonard | Chris Knapp | Dennis Leonard | Dave Hamilton | 529 | 655 | -126 |
| 1976-09-13 | vs KCA | 145 | W 5-4 | 63-82 | 6 | 5,327 | Ken Brett | Al Fitzmorris | Ken Brett | Steve Mingori | | 534 | 659 | -125 |
| 1976-09-14 | vs KCA | 146 | L 1-2 | 63-83 | 6 | 2,762 | Larry Monroe | Andy Hassler | Andy Hassler | Terry Forster | | 535 | 661 | -126 |
| 1976-09-15 | vs TEX | 147 | L 3-4 | 63-84 | 6 | 3,912 | Bart Johnson | Bert Blyleven | Bert Blyleven | Bart Johnson | | 538 | 665 | -127 |
| 1976-09-16 | vs TEX | 148 | L 4-5 | 63-85 | 6 | 1,826 | Ken Kravec | Nelson Briles | Nelson Briles | Ken Kravec | Joe Hoerner | 542 | 670 | -128 |
| 1976-09-17 | @ KCA | 149 | L 2-3 | 63-86 | 6 | 15,087 | Rich Gossage | Dennis Leonard | Dennis Leonard | Rich Gossage | | 544 | 673 | -129 |
| 1976-09-18 | @ KCA | 150 | L 5-6 | 63-87 | 6 | 24,955 | Ken Brett | Al Fitzmorris | Larry Gura | Ken Brett | | 549 | 679 | -130 |
| 1976-09-19 | @ KCA | 151 | L 5-6 | 63-88 | 6 | 39,797 | Chris Knapp | Andy Hassler | Steve Mingori | Terry Forster | | 554 | 685 | -131 |
| 1976-09-21 | vs MIN | 152 | L 6-13 | 63-89 | 6 | 3,026 | Ken Kravec | Jim Hughes | Tom Burgmeier | Ken Kravec | | 560 | 698 | -138 |
| 1976-09-22 | vs MIN | 153 | L 3-6 | 63-90 | 6 | 3,458 | Bart Johnson | Bill Singer | Bill Singer | Bart Johnson | Bill Campbell | 563 | 704 | -141 |
| 1976-09-23 | vs MIN | 154 | L 0-3 | 63-91 | 6 | 3,278 | Ken Brett | Pete Redfern | Pete Redfern | Ken Brett | | 563 | 707 | -144 |
| 1976-09-24 | vs OAK | 155 | W 4-2 | 64-91 | 6 | 12,672 | Francisco Barrios | Paul Mitchell | Francisco Barrios | Rollie Fingers | | 567 | 709 | -142 |
| 1976-09-25 | vs OAK | 156 | L 4-7 | 64-92 | 6 | 17,298 | Rich Gossage | Glenn Abbott | Rollie Fingers | Rich Gossage | | 571 | 716 | -145 |
| 1976-09-29 | @ CAL | 157 | L 0-3 | 64-93 | 6 | 5,650 | Ken Brett | Nolan Ryan | Nolan Ryan | Ken Brett | | 571 | 719 | -148 |
| 1976-09-30 | @ CAL | 158 | L 3-7 | 64-94 | 6 | 6,859 | Larry Monroe | Sid Monge | Sid Monge | Larry Monroe | John Verhoeven | 574 | 726 | -152 |
| 1976-10-01 | @ TEX | 159 | L 8-11 | 64-95 | 6 | 4,907 | Chris Knapp | Jim Umbarger | Steve Hargan | Francisco Barrios | Nelson Briles | 582 | 737 | -155 |
| 1976-10-02 | @ TEX | 160 | L 4-5 | 64-96 | 6 | 9,406 | Bart Johnson | Bert Blyleven | Mike Bacsik | Pete Vuckovich | | 586 | 742 | -156 |
| 1976-10-03 | @ TEX | 161 | L 0-3 | 64-97 | 6 | 4,455 | Rich Gossage | Len Barker | Len Barker | Rich Gossage | | 586 | 745 | -159 |